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https://www.readbyqxmd.com/read/27912744/quality-of-life-after-stroke-in-pakistan
#1
Wardah Khalid, Shafquat Rozi, Tazeen Saeed Ali, Iqbal Azam, Michael T Mullen, Saleem Illyas, Qamar Un-Nisa, Nabila Soomro, Ayeesha Kamran Kamal
BACKGROUND: There is very little information about the quality of life (QOL) of stroke survivors in LMIC countries with underdeveloped non communicable health infrastructures, who bear two thirds of the global stroke burden. METHODOLOGY: We used a sequential mix methods approach. First, a quantitative analytical cross-sectional study was conducted on 700 participants, who constituted 350 stroke survivor and their caregiver dyads. QOL of stroke survivor was assessed via Stroke Specific Quality of Life Scale (SSQOLS) whereas QOL of caregivers was assessed through RAND-36...
December 3, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27907013/development-and-implementation-of-the-ebola-traveler-monitoring-program-and-clinical-outcomes-of-monitored-travelers-during-october-may-2015-minnesota
#2
Aaron DeVries, Pamela Talley, Kristin Sweet, Susan Kline, Patricia Stinchfield, Pritish Tosh, Richard Danila
BACKGROUND: In October 2014, the United States began actively monitoring all persons who had traveled from Guinea, Liberia, and Sierra Leone in the previous 21 days. State public health departments were responsible for monitoring all travelers; Minnesota has the largest Liberian population in the United States. The MDH Ebola Clinical Team (ECT) was established to assess travelers with symptoms of concern for Ebola virus disease (EVD), coordinate access to healthcare at appropriate facilities including Ebola Assessment and Treatment Units (EATU), and provide guidance to clinicians...
2016: PloS One
https://www.readbyqxmd.com/read/27878467/outcomes-of-retesting-brca-negative-patients-using-multigene-panels
#3
Siddhartha Yadav, Ashley Reeves, Sarah Campian, Amy Paine, Dana Zakalik
The utility of multigene panels in retesting patients who previously tested negative for a pathogenic mutation by BRCA1/2 testing is not well established. Patients who previously tested negative for a pathogenic BRCA1/2 mutation by standard sequencing, and who were seen in cancer genetics center between November 1, 2012 and June 30, 2015 for additional testing utilizing multigene panels, were identified using our genetic testing registry. Data on demographics, personal and family history of cancer, results of panel testing and the impact on patient management was collected retrospectively...
November 22, 2016: Familial Cancer
https://www.readbyqxmd.com/read/27865257/pain-and-social-processes-for-hospice-cancer-patients-an-integrative-review
#4
REVIEW
Olga Ehrlich, Rachel K Walker
PURPOSE: Hospice cancer patients experience poorly-controlled pain in spite of widely-disseminated evidence-based guidelines for use by hospice care practitioners. Pain management occurs in the context of the interdisciplinary team, centered on a caring triad in the home: the person with pain, their caregiver, and their nurse. This review: 1) Summarizes what is known about differing ways that members of the hospice caring triad (patients, caregivers, and nurses) interpret and respond to cancer pain, in order to develop a cancer pain social processes theoretical framework, 2) Identifies gaps in understanding of hospice cancer pain social processes, and 3) Identifies framework concepts for research-based clinical practice with potential to improve pain outcomes...
December 2016: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/27845357/participation-in-activities-and-secondary-health-complications-among-persons-aging-with-traumatic-spinal-cord-injury
#5
U Lundström, K Wahman, Å Seiger, D B Gray, G Isaksson, M Lilja
STUDY DESIGN: Cross-sectional study. OBJECTIVES: To describe participation in activities and explore the relationship with secondary complications among persons aging with a traumatic spinal cord injury (SCI). SETTING: A regional SCI outpatient center in Sweden. METHODS: Data were collected through a phone survey, which included 10 activities from the instrument PARTS/M-v3 (PARTicipation Survey/Mobility version-3) together with data from the participants' medical records...
November 15, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27842785/toxicology-in-pain-management
#6
REVIEW
Daniel A Schwarz, M P George, Martin H Bluth
Toxicology testing in pain management has become the standard of care. The Center for Disease Control and Prevention published guidelines including urine drug testing prior to initiating opioid therapy and for monitoring prescription and illicit drugs. Physicians must know indications for toxicology testing, and the frequency based upon risk stratification. This includes personal and family history of alcohol or substance related disorders, mental illness and smoking. Knowledge of opioid metabolism and various matrices to test are described...
December 2016: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/27833690/impact-of-prior-therapeutic-opioid-use-by-emergency-department-providers-on-opioid-prescribing-decisions
#7
Adam C Pomerleau, Jeanmarie Perrone, Jason A Hoppe, Matthew Salzman, Paul S Weiss, Lewis S Nelson
INTRODUCTION: Our study sought to examine the opioid analgesic (OA) prescribing decisions of emergency department (ED) providers who have themselves used OA therapeutically and those who have not. A second objective was to determine if OA prescribing decisions would differ based on the patient's relationship to the provider. METHODS: We distributed an electronic survey to a random sample of ED providers at participating centers in a nationwide research consortium...
November 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27829573/advancing-interprofessional-primary-health-care-services-in-rural-settings-for-people-with-chronic-low-back-disorders-protocol-of-a-community-based-randomized-controlled-trial
#8
Brenna Bath, Stacey Lovo Grona, Stephan Milosavljevic, Nazmi Sari, Biaka Imeah, Megan E O'Connell
BACKGROUND: Chronic low back disorders (CLBDs) are a substantial burden on individuals and societies, and impact up to 20% of Canadians. Rural and remote residents are approximately 30% more likely to have CLBDs. Reduced access to appropriate team-based health services, including physical therapy, is a key factor that may magnify the impact of CLBD on pain, physical function, overall quality of life, health-related system costs, and individual costs. OBJECTIVE: The purpose of this project is to evaluate the validity, comparative effectiveness, costs, barriers, and facilitators of an interprofessional management approach for people with CLBDs, delivered via telehealth...
November 9, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27812859/palliative-care-of-cancer-in-the-older-patient
#9
REVIEW
Lodovico Balducci, Dawn Dolan
The scope of palliative care includes goal setting, symptom management, and care of the care giver. Palliative care is essential for patient-centered care of the older cancer patients. The diversity of this population in terms of life expectancy, treatment tolerance, function, disability, and social support mandates personalized treatment plans. The assessment of physiologic age is currently based on a comprehensive geriatric assessment (CGA). A number of biologic markers of aging including the inflammatory index, the genomic clock, the expression of p16INKa4, and the circulating levels of vitamin D may complement the CGA and fine-tune the determination of physiologic age...
December 2016: Current Oncology Reports
https://www.readbyqxmd.com/read/27793191/comparing-two-sampling-methods-to-engage-hard-to-reach-communities-in-research-priority-setting
#10
Melissa A Valerio, Natalia Rodriguez, Paula Winkler, Jaime Lopez, Meagen Dennison, Yuanyuan Liang, Barbara J Turner
BACKGROUND: Effective community-partnered and patient-centered outcomes research needs to address community priorities. However, optimal sampling methods to engage stakeholders from hard-to-reach, vulnerable communities to generate research priorities have not been identified. METHODS: In two similar rural, largely Hispanic communities, a community advisory board guided recruitment of stakeholders affected by chronic pain using a different method in each community: 1) snowball sampling, a chain- referral method or 2) purposive sampling to recruit diverse stakeholders...
October 28, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27764239/association-between-knee-osteoarthritis-cardiovascular-risk-factors-and-the-framingham-risk-score-in-south-koreans-a-cross-sectional-study
#11
Ho Sun Kim, Joon-Shik Shin, Jinho Lee, Yoon Jae Lee, Me-Riong Kim, Young-Hyeon Bae, Ki Byung Park, Eun-Jung Lee, Joo-Hee Kim, In-Hyuk Ha
BACKGROUND: Osteoarthritis is a significant burden on personal health and for social cost, and its prevalence is rising. Recent research has revealed an association between osteoarthritis and cardiovascular disease, and this study uses the Framingham risk score (FRS), which is widely used as a composite index of cardiovascular risk factors, to investigate the association between osteoarthritis and various cardiovascular risk factors. METHODS: A total 9,514 participants aged 50 years or older who received knee X-ray diagnosis of the 5th Korean National Health and Nutrition Examination Survey (total surveyees = 24,173) released by the Korean Centers for Disease Control and Prevention was included for analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27743840/teaching-caregivers-of-persons-with-dementia-to-address-pain
#12
Mark E Kunik, A Lynn Snow, Nancy Wilson, Amber B Amspoker, Shubhada Sansgiry, Robert O Morgan, Jun Ying, Gayle Hersch, Melinda A Stanley
OBJECTIVES: To compare the efficacy of Preventing Aggression in Veterans with Dementia (PAVeD) with that of usual care in decreasing incidence of aggression (primary outcome) and pain and improving depression, pleasant events, caregiver burden, and patient-caregiver relationship quality (secondary outcomes). DESIGN: Randomized controlled trial with assessments at baseline and 3, 6, 9, and 12 months SETTING: Houston, TX. PARTICIPANTS: A total of 203 community-dwelling veterans with pain and dementia and their caregivers...
April 27, 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27736840/progress-toward-global-eradication-of-dracunculiasis-january-2015-june-2016
#13
Donald R Hopkins, Ernesto Ruiz-Tiben, Mark L Eberhard, Sharon L Roy, Adam J Weiss
Dracunculiasis (Guinea worm disease) is caused by Dracunculus medinensis, a parasitic worm. Approximately 1 year after a person acquires infection from drinking contaminated water, the worm emerges through the skin, usually on the leg. Pain and secondary bacterial infection can cause temporary or permanent disability that disrupts work and schooling. The campaign to eradicate dracunculiasis worldwide began in 1980 at CDC. In 1986, the World Health Assembly called for dracunculiasis elimination (1), and the global Guinea Worm Eradication Program, led by the Carter Center and supported by the World Health Organization (WHO), United Nations Children's Fund (UNICEF), CDC, and other partners, began assisting ministries of health in countries where dracunculiasis was endemic...
October 14, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27730378/diagnostic-value-of-blood-tests-for-occult-causes-of-initially-idiopathic-small-fiber-polyneuropathy
#14
Magdalena Lang, Roi Treister, Anne Louise Oaklander
Small-fiber polyneuropathy (SFPN) causes non-specific symptoms including chronic pain, cardiovascular, gastrointestinal, and sweating complaints. Diagnosis is made from history and exam in patients with known risk factors such as diabetes, but objective test confirmation is recommended for patients without known risks. If tests confirm SFPN, and it is "initially idiopathic" (iiSFPN), screening for occult causes is indicated. This study's aim was to evaluate the 21 widely available, recommended blood tests to identify the most cost-effective ones and to learn about occult causes of iiSFPN...
December 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27727383/close-contact-casting-vs-surgery-for-initial-treatment-of-unstable-ankle-fractures-in-older-adults-a-randomized-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
Keith Willett, David J Keene, Dipesh Mistry, Julian Nam, Elizabeth Tutton, Robert Handley, Lesley Morgan, Emma Roberts, Andrew Briggs, Ranjit Lall, Timothy J S Chesser, Ian Pallister, Sarah E Lamb
Importance: Ankle fractures cause substantial morbidity in older persons. Surgical fixation is the contemporary intervention but is associated with infection and other healing complications. Objective: To determine whether initial fracture treatment with close contact casting, a molded below-knee cast with minimal padding, offers outcome equivalent to that with immediate surgery, with fewer complications and less health resource use. Design, Setting, and Participants: This was a pragmatic, equivalence, randomized clinical trial with blinded outcome assessors...
October 11, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27693895/missed-opportunities-a-mixed-methods-analysis-of-cam-discussions-and-practices-in-the-management-of-pain-in-oncology
#16
Aaron L Leppin, Cara Fernandez, Jon C Tilburt
CONTEXT: Treatment of pain in cancer is a clinical priority. Many cancer patients seek and use complementary and alternative medicine (CAM) therapies. OBJECTIVES: The aim of this study was to describe the role CAM plays in oncology, clinicians' approaches to pain management and its alignment with patient preference and self-care. METHODS: We used quantitative criteria to identify patients with high, self-reported pain and reduced quality of life...
November 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27693732/oswestry-disability-index-a-psychometric-analysis-with-1-610-patients
#17
Darrel S Brodke, Vadim Goz, Brandon D Lawrence, W Ryan Spiker, Ashley Neese, Man Hung
BACKGROUND: One-fourth of the adult US population has or will experience back pain and has undergone one of a myriad of treatments. Understanding the outcomes of these many treatments from pharmacologic to surgical, from manipulation to modality, allows for a better understanding and value-driven decision making. Patient-reported outcome measures are the current standard and include general and disease-specific measures. The Oswestry Disability Index (ODI) is the most commonly used disease-specific patient-reported outcome tool to measure functional disability related to back pain...
September 29, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27668709/self-reported-symptoms-8weeks-after-discharge-a-comparison-of-takotsubo-syndrome-and-myocardial-infarction
#18
Sara Wallström, Kerstin Ulin, Elmir Omerovic, Inger Ekman
BACKGROUND: Takotsubo syndrome is a form of acute, reversible heart failure that has gained increasing attention. It affects mostly postmenopausal women, and its acute onset and symptoms mimic acute myocardial infarction. The distinct feature of takotsubo syndrome is the ballooning of a ventricle, but the complete pathophysiological mechanisms are not fully understood. Both short-term and long-term survival are affected, but little is known about the illness experience and self-reported residual symptoms after discharge from hospital...
September 16, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27662884/implementation-of-a-multicenter-biobanking-collaboration-for-next-generation-sequencing-based-biomarker-discovery-based-on-fresh-frozen-pretreatment-tumor-tissue-biopsies
#19
Sander Bins, Geert A Cirkel, Christa G Gadellaa-van Hooijdonk, Fleur Weeber, Isaac J Nijman, Annette H Bruggink, Paul J van Diest, Stefan M Willems, Wouter B Veldhuis, Michel M van den Heuvel, Rob J de Knegt, Marco J Koudijs, Erik van Werkhoven, Ron H J Mathijssen, Edwin Cuppen, Stefan Sleijfer, Jan H M Schellens, Emile E Voest, Marlies H G Langenberg, Maja J A de Jonge, Neeltje Steeghs, Martijn P Lolkema
BACKGROUND: The discovery of novel biomarkers that predict treatment response in advanced cancer patients requires acquisition of high-quality tumor samples. As cancer evolves over time, tissue is ideally obtained before the start of each treatment. Preferably, samples are freshly frozen to allow analysis by next-generation DNA/RNA sequencing (NGS) but also for making other emerging systematic techniques such as proteomics and metabolomics possible. Here, we describe the first 469 image-guided biopsies collected in a large collaboration in The Netherlands (Center for Personalized Cancer Treatment) and show the utility of these specimens for NGS analysis...
September 23, 2016: Oncologist
https://www.readbyqxmd.com/read/27636230/ophthalmic-presentation-of-giant-cell-arteritis-in-african-americans
#20
S T Garrity, M Pistilli, M S Vaphiades, N Q Richards, P S Subramanian, P R Rosa, B L Lam, B J Osborne, G T Liu, K E Duncan, R K Shin, N J Volpe, K S Shindler, M S Lee, M L Moster, E H Tracey, S E Cuprill-Nilson, M A Tamhankar
PurposeTo determine the differences in the presentation of ophthalmic giant cell arteritis between African-Americans and Caucasians.MethodsThis was a multicenter retrospective case series comparing African-American patients with ophthalmic GCA to a previously published Caucasian cohort. Neuro-ophthalmic centers across the United States were contacted to provide data on African-American patients with biopsy-proven ophthalmic giant cell arteritis. The differences between African-American and Caucasian patients with respect to multiple variables, including age, sex, systemic and ophthalmic signs and symptoms, ocular ischemic lesions, and laboratory results were studied...
September 16, 2016: Eye
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