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https://www.readbyqxmd.com/read/28087936/fungal-ligninolytic-enzymes-and-their-applications
#1
Miia R Mäkelä, Erin L Bredeweg, Jon K Magnuson, Scott E Baker, Ronald P de Vries, Kristiina Hildén
The global push toward an efficient and economical biobased economy has driven research to develop more cost-effective applications for the entirety of plant biomass, including lignocellulosic crops. As discussed elsewhere (Karlsson M, Atanasova L, Funck Jensen D, Zeilinger S, in Heitman J et al. [ed], Tuberculosis and the Tubercle Bacillus, 2nd ed, in press), significant progress has been made in the use of polysaccharide fractions from lignocellulose, cellulose, and various hemicellulose types. However, developing processes for use of the lignin fraction has been more challenging...
December 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28087435/postmyelotomy-closure-of-spinal-cord-zip-lock-technique-an-initial-experience
#2
Daljit Singh, Shaam Bodeliwala, Hukum Singh, Anita Jagetia, Amit Mittal
Proper closure of the pia matter is necessary to restore the normal anatomy and prevent postoperative painful dysesthesia after excision of intramedullary spinal cord tumor. Two methods of closure of the pia have been described: welding technique and conventional suturing. Here, we report our initial experience with a new "pial press" or "zip-lock" technique for pial closure where pial layers are simply held together and plunged into each other with small micro tooth forceps. Advantages of the technique over other techniques are its less chances of suture related complications or trauma to the posterior column and simplicity of the technique...
January 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28086982/reproductive-factors-and-the-risk-of-triple-negative-breast-cancer-in-white-women-and-african-american-women-a-pooled-analysis
#3
Huiyan Ma, Giske Ursin, Xinxin Xu, Eunjung Lee, Kayo Togawa, Lei Duan, Yani Lu, Kathleen E Malone, Polly A Marchbanks, Jill A McDonald, Michael S Simon, Suzanne G Folger, Jane Sullivan-Halley, Dennis M Deapen, Michael F Press, Leslie Bernstein
BACKGROUND: Early age at menarche, nulliparity, late age at first completed pregnancy, and never having breastfed, are established breast cancer risk factors. However, among breast cancer subtypes, it remains unclear whether all of these are risk factors for triple-negative breast cancer (TNBC). METHODS: We evaluated the associations of these reproductive factors with TNBC, in 2658 patients with breast cancer (including 554 with TNBC) and 2448 controls aged 20-64 years, who participated in one of the three population-based case-control studies: the Women's Contraceptive and Reproductive Experiences Study, the Women's Breast Carcinoma in situ Study, or the Women's Learning the Influence of Family and Environment Study...
January 13, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28081180/pi3k%C3%AE-deficient-nod-mice-are-protected-from-diabetes-by-restoring-the-balance-of-regulatory-to-effector-t-cells
#4
Jamil Azzi, Lindsay Thueson, Robert Moore, Rozita Abdoli, Helena Reijonen, Reza Abdi
With a steady increase in its incidence and lack of curative treatment, type 1 diabetes (T1D) has emerged as a major health problem worldwide. To design novel effective therapies, there is a pressing need to identify regulatory targets controlling the balance of autoreactive to regulatory-T-cells (Tregs). We previously showed that the inhibition of the γ-subunit of the Phosphoinositide-3-kinase (PI3K), significantly suppress autoimmune-diabetes. To further delineate the mechanisms and the selectivity of specific immune modulation by PI3Kγ-inhibition, we developed a new NOD mouse model of T1D lacking the γ-subunit of PI3K...
2017: PloS One
https://www.readbyqxmd.com/read/28080221/molecular-mechanisms-of-antisense-oligonucleotides
#5
Stanley T Crooke
In 1987, when I became interested in the notion of antisense technology, I returned to my roots in RNA biochemistry and began work to understand how oligonucleotides behave in biological systems. Since 1989, my research has focused primarily on this topic, although I have been involved in most areas of research in antisense technology. I believe that the art of excellent science is to frame large important questions that are perhaps not immediately answerable with existing knowledge and methods, and then conceive a long-term (multiyear) research strategy that begins by answering the most pressing answerable questions on the path to the long-term goals...
January 12, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/28079908/hot-off-the-press
#6
Robert A Hill, Andrew Sutherland
A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as hitorin A from Chloranthus japonicus.
January 12, 2017: Natural Product Reports
https://www.readbyqxmd.com/read/28079288/surface-enhanced-raman-spectra-promoted-by-a-finger-press-in-an-all-solid-state-flexible-energy-conversion-and-storage-film
#7
Haitao Li, Han Dai, Yihe Zhang, Wangshu Tong, Hua Gao, Qi An
Electrochemically up-regulated surface-enhanced Raman spectroscopy (E-SERS) effectively increases Raman signal intensities. However, the instrumental requirements and the conventional measurement conditions in an electrolyte cell have hampered its application in fast and on-site detection. To circumvent the inconveniences of E-SERS, we propose a self-energizing substrate that provides electrical potential by converting film deformation from a finger press into stored electrical energy. The substrate combines an energy conversion film and a SERS-active Ag nanowire layer...
January 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28078985/designing-isoform-selective-inhibitors-against-classical-hdacs-for-effective-anticancer-therapy-insight-and-perspectives-from-in-silico
#8
Shabir Ahmad Ganai
Histone deacetylase inhibitors, the small molecules modulating the biological activity of histone deacetylases are emerging as potent chemotherapeutic agents. Despite their considerable therapeutic benefits in disease models, the lack of isoform specificity culminates in debilitating off target effects, raising serious concerns regarding their applicability. This emphasizes the pressing and unmet medical need of designing isoform selective inhibitors for safe and effective anticancer therapy. Keeping these grim facts in view, the current article sheds light on structural basis of off-targeting...
12, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/28078924/book-review-cognitive-aging-progress-in-understanding-and-opportunities-for-action-cognitive-aging-progress-in-understanding-and-opportunities-for-action-edited-by-blazer-d-g-yaffe-k-liverman-c-t-committee-on-the-public-health-dimensions-of-cognitive-ageing
#9
https://www.readbyqxmd.com/read/28078170/computational-fluid-dynamics-assisted-characterization-of-parafoveal-hemodynamics-in-normal-and-diabetic-eyes-using-adaptive-optics-scanning-laser-ophthalmoscopy
#10
Yang Lu, Miguel O Bernabeu, Jan Lammer, Charles C Cai, Martin L Jones, Claudio A Franco, Lloyd Paul Aiello, Jennifer K Sun
Diabetic retinopathy (DR) is the leading cause of visual loss in working-age adults worldwide. Previous studies have found hemodynamic changes in the diabetic eyes, which precede clinically evident pathological alterations of the retinal microvasculature. There is a pressing need for new methods to allow greater understanding of these early hemodynamic changes that occur in DR. In this study, we propose a noninvasive method for the assessment of hemodynamics around the fovea (a region of the eye of paramount importance for vision)...
December 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/28077905/biomedical-scientific-and-professional-social-networks-in-the-service-of-the-development-of-modern-scientific-publishing
#11
Izet Masic, Edin Begic
Information technologies have found their application in virtually every branch of health care. In recent years they have demonstrated their potential in the development of online library, where scientists and researchers can share their latest findings. Academia.edu, ResearchGate, Mendeley, Kudos, with the support of platform GoogleScholar, have indeed increased the visibility of scientific work of one author, and enable a much greater availability of the scientific work to the broader audience. Online libraries have allowed free access to the scientific content to the countries that could not follow the economic costs of getting access to certain scientific bases...
December 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28077637/role-of-litopenaeus-vannamei-yin-yang-1-in-the-regulation-of-the-white-spot-syndrome-virus-immediate-early-gene-ie1
#12
Ping-Han Huang, Ting-Yi Huang, Pei-Si Cai, Li-Kwan Chang
: Yin Yang 1 (YY1) is a multifunctional zinc-finger transcription factor that regulates many key cellular processes. In this study, we report the cloning of YY1 from shrimp, Litopenaeus vannamei, (LvYY1). The study shows that LvYY1 is ubiquitously expressed in shrimp tissues, and knockdown of LvYY1 expression by dsRNA injection in WSSV-infected shrimp reduced both mRNA levels of the WSSV immediate-early gene, ie1, as well as overall copy numbers of the WSSV genome. The cumulative mortality of infected shrimp also declined with LvYY1 dsRNA injection...
January 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28077462/bromodomains-in-protozoan-parasites-evolution-function-and-opportunities-for-drug-development
#13
REVIEW
Victoria Jeffers, Chunlin Yang, Sherri Huang, William J Sullivan
Parasitic infections remain one of the most pressing global health concerns of our day, affecting billions of people and producing unsustainable economic burdens. The rise of drug-resistant parasites has created an urgent need to study their biology in hopes of uncovering new potential drug targets. It has been established that disrupting gene expression by interfering with lysine acetylation is detrimental to survival of apicomplexan (Toxoplasma gondii and Plasmodium spp.) and kinetoplastid (Leishmania spp...
March 2017: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/28076975/book-reviews-boltz-marie-and-galvin-james-e-eds-dementia-care-an-evidence-based-approach-springer-international-publishing-switzerland-2016-325-pp-ibsn-978-3-319-18376-3-129-00-sbk-beard-ren%C3%A3-e-l-living-with-alzheimer-s-managing-memory-loss-identity-and-illness
#14
https://www.readbyqxmd.com/read/28076015/us-and-mr-imaging-of-pectoralis-major-injuries
#15
Yauk K Lee, Matt R Skalski, Eric A White, Anderanik Tomasian, Diane D Phan, Dakshesh B Patel, George R Matcuk, Aaron J Schein
During the past 2 decades, the frequency of pectoralis major muscle injuries has increased in association with the increased popularity of bench press exercises. Injury of the pectoralis major can occur at the muscle origin, muscle belly, musculotendinous junction, intratendinous region, and/or humeral insertion-with or without bone avulsion. The extent of the tendon injury ranges from partial to complete tears. Treatment may be surgical or conservative, depending on the clinical scenario and anatomic characteristics of the injury...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28075584/review-of-medicinal-and-aromatic-plants-industrial-profiles-volume-48-sesame-the-genus-sesamum-medicinal-and-aromatic-plants-industrial-profiles-volume-48-sesame-the-genus-sesamum-edited-by-d-bedigian-missouri-botanical-garden-st-louis-missouri-crc-press-taylor
#16
https://www.readbyqxmd.com/read/28074697/book-review-health-promotion-ideology-discipline-and-specialism-health-promotion-ideology-discipline-and-specialism-written-by-kemm-j-published-by-oxford-university-press-oxford-2015-paperback-240-pp-isbn-9780198713999
#17
https://www.readbyqxmd.com/read/28074543/low-distress-tolerance-predicts-heightened-drug-seeking-and-taking-after-extended-abstinence-from-cocaine-self-administration
#18
Travis M Moschak, Douglas R Terry, Stacey B Daughters, Regina M Carelli
Distress tolerance (DT), defined as the ability to persist in goal-directed behavior while experiencing psychological distress, is associated with greater frequency of substance use and poor treatment outcomes. To examine a potential causal role substance use may play in DT, we developed a rodent model of DT in which rats had to press a lever within a continuously decreasing time window for reward while receiving negative feedback on failure trials. DT was defined as the time rats continued to seek reward before quitting the task...
January 11, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28074422/compacted-multiparticulate-systems-for-colon-specific-delivery-of-ketoprofen
#19
Rodrigo Gomes de Alencar, Aline Carlos de Oliveira, Eliana Martins Lima, Marcílio Sérgio Soares da Cunha-Filho, Stephânia Fleury Taveira, Ricardo Neves Marreto
Pellet-containing tablets for colon-specific drug delivery present higher targeting efficiency and lower costs when compared with monolithic tablets and pellet-filled capsules, respectively. In this study, pellets containing ketoprofen were coated with different acrylic polymers and submitted to compaction. The influence of formulation and process factors on film integrity was then evaluated. Pellets were prepared via extrusion-spheronization and coated using two acrylic polymers (Eudragit® FS 30 D and Opadry® 94 k28327, PMMA and PMA, respectively)...
January 10, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28074386/the-effect-of-ceramic-thickness-and-resin-cement-shades-on-the-color-matching-of-ceramic-veneers-in-discolored-teeth
#20
Wenzhong Xing, Xiaodong Chen, Dafei Ren, Kangru Zhan, Yining Wang
The objective of this study was to analyze the effects of ceramic material thickness and resin cement shade on the color matching of ceramic veneers at the gray tooth structures. Seventy-two artificial maxillary right central incisor teeth (C2 shade) were prepared according to veneer tooth preparation in practice. Ceramic materials (LT, A2 shade, IPS e.max Press) were selected to fabricate the 0.50- and 0.75-mm thick veneers at the body region. The ceramic veneer specimens were bonded to the artificial teeth by the 6 shades of resin cements (Variolink Veneer: shades of HV+3, LV-2, LV-3; and RelyX(TM) Veneer: shades of WO, TR, A3)...
January 10, 2017: Odontology
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