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https://www.readbyqxmd.com/read/28548569/thyroxine-increases-collagen-type-ii-expression-and-accumulation-in-scaffold-free-tissue-engineered-articular-cartilage
#1
G Adam Whitney, Thomas J Kean, Russell J Fernandes, Stephen D Waldman, M Yat Tse, Stephen C Pang, Joseph M Mansour, James E Dennis
Low collagen accumulation in the extra-cellular matrix is a pressing problem in cartilage tissue engineering, leading to a low collagen-to-glycosaminoglycan (GAG) ratio and poor mechanical properties in neo-cartilage. Soluble factors have been shown to increase collagen content, but may result in a more pronounced increase in GAG content. Thyroid hormones have been reported to stimulate collagen and GAG production, but reported outcomes, including which specific collagen types are affected, are variable throughout the literature...
May 26, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28548350/koenig-and-schultz-s-disaster-medicine-comprehensive-principles-and-practices-2nd-ed-edited-by-kristi-l-koenig-carl-h-schultz-new-york-cambridge-university-press-2016-736-pp-index-205-00-hardcover
#2
REVIEW
Eric C Silverman, Mary P Mercer
No abstract text is available yet for this article.
April 27, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28547824/the-promise-of-a-better-group-future-cognitive-alternatives-increase-students-self-efficacy-and-academic-performance
#3
Aarti Iyer, Airong Zhang, Jolanda Jetten, Zhen Hao, Lijuan Cui
Drawing on classic social identity theorizing (Tajfel, Differentiation between social groups: Studies in the social psychology of intergroup relations, London, UK, Academic Press, 1978), we propose that low-status minority group members' self-efficacy and performance on intellectual tasks can be enhanced by prompting them to believe in a better future for their group (i.e., increasing awareness of cognitive alternatives to the existing low-status position). Study 1 manipulated cognitive alternatives among 157 migrant workers' children in China, showing that self-efficacy was enhanced in the high compared to the low cognitive alternative condition...
May 25, 2017: British Journal of Social Psychology
https://www.readbyqxmd.com/read/28546930/implantation-of-trabecular-micro-bypass-stent-using-a-novel-landing-strip-technique
#4
Cindy X Zheng, Marlene R Moster, Priyanka Gogte, Yang Dai, Remy S Manzi, Michael Waisbourd
AIM: To describe a novel technique of creating a landing strip within the trabecular meshwork to guide trabecular micro-bypass stent (iStent) implantation in patients who underwent phacoemulsification. METHODS: Thirty-four eyes from 30 patients who underwent iStent implantation after phacoemulsification from May 2014 to February 2015 were included in our retrospective study. All iStents were implanted via the "landing strip" technique. A 25-gauge microvitreoretinal blade was used to bisect the trabecular meshwork to less than 1 clock-hour, effectively creating a landing strip...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546928/modified-deep-sclerectomy-combined-with-ex-press-filtration-device-versus-trabeculectomy-for-primary-open-angle-glaucoma
#5
Vassilios Kozobolis, Georgios D Panos, Aristeidis Konstantinidis, Miguel Teus, Georgios Labiris
AIM: To compare the efficacy of modified deep sclerectomy combined with Ex-PRESS shunt versus trabeculectomy in primary open angle glaucoma. METHODS: This is a prospective cohort comparative single-center study. Forty-nine eyes of 49 patients were enrolled in the study. Patients were randomly divided into two groups. Group A (22 patients) underwent classic trabeculectomy and group B (27 patients) underwent modified deep sclerectomy combined with insertion of Ex-PRESS model P50 drainage device...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546646/canaries-in-a-coal-mine-what-the-killings-of-journalists-tell-us-about-future-repression
#6
Anita R Gohdes, Sabine C Carey
An independent press that is free from government censorship is regarded as instrumental to ensuring human rights protection. Yet governments across the globe often target journalists when their reports seem to offend them or contradict their policies. Can the government's infringements of the rights of journalists tell us anything about its wider human rights agenda? The killing of a journalist is a sign of deteriorating respect for human rights. If a government orders the killing of a journalist, it is willing to use extreme measures to eliminate the threat posed by the uncontrolled flow of information...
March 2017: Journal of Peace Research
https://www.readbyqxmd.com/read/28543944/anterior-cingulate-cortex-supports-effort-allocation-toward-a-qualitatively-preferred-option
#7
Evan E Hart, Julian O Gerson, Yael Zoken, Marisella Garcia, Alicia Izquierdo
The anterior cingulate cortex (ACC) is known to be involved in effortful choice, yet its role in cost-benefit evaluation of qualitatively different rewards (more/less preferred), beyond magnitude differences (larger/smaller), is poorly understood. Selecting between qualitatively different options is a decision type commonly faced by humans. Here we assessed the role of ACC on a task that has primarily been used to probe striatal function in motivation. Rats were trained to stable performance on a progressive ratio schedule for sucrose pellets and were then given sham surgeries (control) or excitotoxic NMDA-lesions of ACC...
May 20, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28543657/ethical-principles-process-and-the-work-of-bioethics-commissions
#8
Daniel P Sulmasy
Shortly after the Presidential Commission for the Study of Bioethical Issues was constituted in 2010 and days before the commission members were to join a conference call to discuss possible topics for their deliberation, Craig Venter held a press conference announcing that his lab had created a synthetic chromosome for a species of mycoplasma and had inserted this genetic material into organisms of another species of mycoplasma (the genes of which had been deactivated), transforming the host species into the donor species...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28543652/what-s-the-use-disparate-purposes-of-u-s-federal-bioethics-commissions
#9
Jenny Dyck Brian, Robert Cook-Deegan
In the forty-year history of U.S. bioethics commissions, these government-sanctioned forums have often demonstrated their power to address pressing problems and to enable policy change. For example, the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research, established in 1974, left a legacy of reports that were translated into regulations and had an enormous practical impact. And the 1982 report Splicing Life, by the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research, became the basis for the National Institutes of Health's Recombinant DNA Advisory Committee as well as for the Food and Drug Administration's developing "Points to Consider" when contemplating the introduction of recombinant DNA into human beings...
May 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28542061/the-impact-of-community-input-in-community-health-needs-assessments
#10
Thomas K Bias, Christiaan G Abildso, Emily Vasile, Jessica Coffman
OBJECTIVE: To determine the impact of community participation on nonprofit hospital priorities as outlined in a Community Health Needs Assessment. DESIGN: Using 3 completed Community Health Needs Assessments, we compare key stakeholder survey responses with community survey responses and determine their contribution to the finalized priorities. SETTING: Three communities in West Virginia served by nonprofit hospitals (1 metropolitan statistical area, 1 micropolitan statistical area, and 1 rural community)...
July 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28541737/book-review-therapy-over-50-aging-issues-in-psychotherapy-and-the-therapist-s-life-kottler-jeffrey-a-carlson-jon-new-york-oxford-university-press-2016
#11
Neil Raveen Jeyasingam
No abstract text is available yet for this article.
June 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28541212/improvement-in-offaxis-neuromuscular-control-under-slippery-conditions-following-6-week-pivoting-neuromuscular-training
#12
Song Joo Lee, Yupeng Ren, Joel Press, Jungwha Lee, Li-Qun Zhang
Knee injuries are usually associated with offaxis loadings in the transverse and frontal planes. Thus, improvement of lower limb offaxis neuromuscular control is important in knee injury prevention and post-injury rehabilitation. The goal of this study was to investigate the effects of 6-week pivoting offaxis intensity adjustable neuromuscular control training (POINT) using a custom-made offaxis elliptical trainer on lower limb offaxis neuromuscular control performance in trained and untrained functional tasks under slippery conditions...
May 18, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28540356/data-on-expression-of-genes-involved-in-estrogen-and-progesterone-action-inflammation-and-differentiation-according-to-demographic-histopathological-and-clinical-characteristics-of-endometrial-cancer-patients
#13
Maša Sinreih, Saša Štupar, Luka Čemažar, Ivan Verdenik, Snježana Frković Grazio, Špela Smrkolj, Tea Lanišnik Rižner
Endometrial cancer is the sixth most common cancer in women worldwide. It is associated with aberrant actions of steroid hormones, estrogens and progesterone, but also with enhanced inflammation and reduced cellular differentiation. Here, we show data on demographic and histopathological characteristics of 51 patients with endometrial cancer, together with data on correlations between the expression of 38 genes involved in estrogen and progesterone actions, inflammation and differentiation, and demographic characteristics...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28539907/task-dominance-determines-backward-inhibition-in-task-switching
#14
Kerstin Jost, Vera Hennecke, Iring Koch
Switching between tasks is assumed to be accompanied by inhibiting currently irrelevant, but competing tasks. A dominant task that strongly interferes with performing a weaker task may receive especially strong inhibition. We tested this prediction by letting participants switch among three tasks that differ in dominance: a location discrimination task with strong stimulus-response bindings (responding with left-hand and right-hand button presses to stimuli presented left or right to the fixation cross) was combined with a color/pattern and a shape discrimination task, for which stimulus-response mappings were arbitrary (e...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28539858/relationship-between-proxies-for-type-ii-fiber-type-and-resting-blood-pressure-in-division-i-american-football-athletes
#15
Christopher A DiCesare, James R Adams, Randal P Claytor, Rose M Ward, Ronald H Cox
OBJECTIVE: The risk for cardiovascular disease is well-documented. Perhaps surprisingly, specific athletic populations, including American football players, exhibit increased risk for cardiovascular disease as presented by elevated blood pressure. There is evidence suggesting a link between muscle fiber type distribution and resting blood pressure. Acknowledging this association, it becomes important to clarify an individual's risk for developing cardiovascular disease later in adulthood...
April 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28539416/the-extinction-of-cocaine-seeking-requires-a-window-of-infralimbic-pyramidal-neuron-activity-after-unreinforced-lever-presses
#16
Andrea L Gutman, Kelle E Nett, Caitlin V Cosme, Wensday R Worth, Subhash C Gupta, John A Wemmie, Ryan T LaLumiere
The infralimbic cortex (IL) mediates the extinction learning and active suppression of cocaine-seeking behavior. However, the precise temporal relationship among IL activity, lever pressing, and extinction learning is unclear. To address this issue, we employed activity-guided optogenetics in male Sprague-Dawley rats to optically silence IL pyramidal neurons for 20 s immediately following unreinforced lever presses during early extinction training after cocaine self-administration. Optical inhibition of the IL increased active lever pressing during shortened extinction sessions but did not alter the retention of the extinction learning as assessed in ensuing extinction sessions with no optical inhibition...
May 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28538600/topical-geospatial-and-temporal-diffusion-of-the-2015-north-american-menopause-society-position-statement-on-nonhormonal-management-of-vasomotor-symptoms
#17
Janet S Carpenter, Tei Laine, Blake Harrison, Meghan LePage, Taran Pierce, Nathan Hoteling, Katy Börner
OBJECTIVE: We sought to depict the topical, geospatial, and temporal diffusion of the 2015 North American Menopause Society position statement on the nonhormonal management of menopause-associated vasomotor symptoms released on September 21, 2015, and its associated press release from September 23, 2015. METHODS: Three data sources were used: online news articles, National Public Radio, and Twitter. For topical diffusion, we compared keywords and their frequencies among the position statement, press release, and online news articles...
May 22, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28538293/comparison-of-strength-levels-between-players-from-within-the-same-club-who-were-selected-vs-not-selected-to-play-in-the-grand-final-of-the-national-rugby-league-competition
#18
Daniel G Baker
Baker, DG. Comparison of strength levels between players from within the same club that were selected vs. not selected to play in the grand final of the National Rugby League competition. J Strength Cond Res 31(6): 1461-1467, 2017-A number of studies have established that higher levels of strength and power, tested at the end of the preseason, distinguish between playing level in professional rugby league. How this may impact the ability of players to get selected for final payoff games some 30 weeks later has not been fully investigated...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538149/icon-an-adaptation-of-infinite-hmms-for-time-traces-with-drift
#19
Ioannis Sgouralis, Steve Pressé
Bayesian nonparametric methods have recently transformed emerging areas within data science. One such promising method, the infinite hidden Markov model (iHMM), generalizes the HMM that itself has become a workhorse in single molecule data analysis. The iHMM goes beyond the HMM by self-consistently learning all parameters learned by the HMM in addition to learning the number of states without recourse to any model selection steps. Despite its generality, simple features (such as drift), common to single molecule time traces, result in an overinterpretation of drift and the introduction of artifact states...
May 23, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28538142/an-introduction-to-infinite-hmms-for-single-molecule-data-analysis
#20
REVIEW
Ioannis Sgouralis, Steve Pressé
The hidden Markov model (HMM) has been a workhorse of single-molecule data analysis and is now commonly used as a stand-alone tool in time series analysis or in conjunction with other analysis methods such as tracking. Here, we provide a conceptual introduction to an important generalization of the HMM, which is poised to have a deep impact across the field of biophysics: the infinite HMM (iHMM). As a modeling tool, iHMMs can analyze sequential data without a priori setting a specific number of states as required for the traditional (finite) HMM...
May 23, 2017: Biophysical Journal
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