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https://www.readbyqxmd.com/read/29691866/gold-lotion-from-citrus-peel-extract-ameliorates-imiquimod-induced-psoriasis-like-dermatitis-in-murine
#1
Chi-Chien Lin, Jung-Ju Wu, Yi-Gen Pan, Ya-Hsuan Chao, Fang-Chu Lin, Ying-Ray Lee, Ching-Liang Chu
BACKGROUND: A natural mixed product Gold lotion (GL), which is made from the peels of six citrus fruits, has recently been identified to possess anti-oxidative, anti-inflammatory, and immunomodulatory effects. GL has been used to protect skin against UV-induced damage, but the activity to psoriasis, a chronic autoimmune skin disease caused by dysregulation between immune cells and keratinocytes, is not known. Thus, we evaluated the effect of GL on imiquimod (IMQ)-induced psoriasis-like inflammation in mice...
April 24, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29691233/evaluation-of-biodistribution-of-sulforaphane-after-administration-of-oral-broccoli-sprout-extract-in-melanoma-patients-with-multiple-atypical-nevi
#2
Shawn Tahata, Shivendra V Singh, Yan Lin, Eun-Ryeong Hahm, Jan H Beumer, Susan M Christner, Uma N Rao, Cindy Sander, Ahmad A Tarhini, Hussein Tawbi, Laura K Ferris, Melissa Wilson, Amy Rose, Catherine M Dietz, Ellen K Hughes, Jed W Fahey, Sancy A Leachman, Pamela B Cassidy, Lisa H Butterfield, Hassane M Zarour, John M Kirkwood
Broccoli sprout extract containing sulforaphane (BSE-SFN) has been shown to inhibit ultraviolet radiation-induced damage and tumor progression in skin. This study evaluated the toxicity and potential effects of oral BSE-SFN at three dosages. Seventeen patients who each had at least 2 atypical nevi and a prior history of melanoma were randomly allocated to 50, 100, or 200 µmol oral BSE-SFN daily for 28 days. Atypical nevi were photographed on days 1 and 28, and plasma and nevus samples were taken on days 1, 2, and 28...
April 24, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29691121/stabilization-of-microtubules-restores-barrier-function-after-cytokine-induced-defects-in-reconstructed-human-epidermis
#3
Chiung-Yueh Hsu, Nicolas Lecland, Valérie Pendaries, Cécile Viodé, Daniel Redoulès, Carle Paul, Andreas Merdes, Michel Simon, Christiane Bierkamp
BACKGROUND: A variety of human skin disorders is characterized by defects in the epidermal barrier, leading to dehydration, itchiness, and rashes. Previously published literature suggests that microtubule stabilization at the cortex of differentiating keratinocytes is necessary for the formation of the epidermal barrier. OBJECTIVES: We tested whether stabilization of microtubules with paclitaxel or epothilone B can repair barrier defects that were experimentally induced in three-dimensional culture models of epidermis...
April 18, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29690804/expression-of-macrophage-migration-inhibitory-factor-in-footpad-skin-lesions-with-diabetic-neuropathy
#4
Sun Up Noh, Won-Young Lee, Won-Serk Kim, Yong-Taek Lee, Kyung Jae Yoon
Background Diabetic neuropathy (DN) originating in distal lower extremities is associated with pain early in the disease course, overwhelming in the feet. However, the pathogenesis of DN remains unclear. Macrophage migration inhibitory factor (MIF) has been implicated in the onset of neuropathic pain and the development of diabetes. Objective of this study was to observe pain syndromes elicited in the footpad of DN rat model and to assess the contributory role of MIF in the pathogenesis of DN. Methods DN was made in SD rats by streptozotocin (STZ)...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29690549/astaxanthin-in-skin-health-repair-and-disease-a-comprehensive-review
#5
REVIEW
Sergio Davinelli, Michael E Nielsen, Giovanni Scapagnini
Astaxanthin, a xanthophyll carotenoid, is a secondary metabolite naturally synthesized by a number of bacteria, microalgae, and yeasts. The commercial production of this pigment has traditionally been performed by chemical synthesis, but the microalga Haematococcus pluvialis appears to be the most promising source for its industrial biological production. Due to its collective diverse functions in skin biology, there is mounting evidence that astaxanthin possesses various health benefits and important nutraceutical applications in the field of dermatology...
April 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29689312/wound-healing-property-of-milk-in-full-thickness-wound-model-of-rabbit
#6
Ali Asghar Hemmati, Anahita Rezaei, Amir Larki-Harchegani, Gholamreza Housmand, Somayeh Shabib, Amir Jalali
OBJECTIVE: Wound healing consists of several continuous phases in which various cells and chemical intermediates are involved. Milk as a rich source of nutrition elements has proved to have potential benefits of treatment of various diseases. The present study was designed to investigate the healing effect of low-fat cow's milk on an open skin wound model in rabbits. METHODS: The 2%, 5%, and 10% (w/w) ointments of lyophilized powder of low-fat milk were prepared ineucerin base and were applied twice daily in the treatment groups...
April 21, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29689250/card14-gain-of-function-mutation-alone-is-sufficient-to-drive-il-23-il-17-mediated-psoriasiform-skin-inflammation-in-vivo
#7
Mark Mellett, Barbara Meier, Deepa Mohanan, Rebekka Schairer, Phil Cheng, Takashi K Satoh, Betina Kiefer, Caroline Ospelt, Stephan Nobbe, Margot Thome, Emmanuel Contassot, Lars E French
Rare autosomal dominant mutations in the gene encoding the keratinocyte signaling molecule, Caspase Recruitment Domain-Containing Protein 14 (CARD14), have been associated with an increased susceptibility to psoriasis but the physiological impact of CARD14 gain-of-function mutations remains to be fully determined in vivo. Here, we report that heterozygous mice harboring a CARD14 gain-of-function mutation (Card14ΔE138) spontaneously develop a chronic psoriatic phenotype with characteristic scaling skin lesions, epidermal thickening, keratinocyte hyperproliferation, hyperkeratosis and immune cell infiltration...
April 21, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29689138/histopathological-patterns-in-dermatitis-artefacta
#8
REVIEW
Jörg Tittelbach, Melanie Peckruhn, Peter Elsner
BACKGROUND: Dermatitis artefacta is a relevant and frequently unrecognized clinical condition associated with self-harming behavior, in which unconscious manipulation causes skin lesions. While atypical lesions and an unusual disease course may give rise to clinical suspicion of a self-induced disorder, questioning and examining these patients usually fails to confirm or clarify this suspicion. In this setting, the dermatopathologist may be faced with the question whether there are any histological signs corroborating the diagnosis of dermatitis artefacta...
April 24, 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29687742/amniotic-membrane-and-its-epithelial-and-mesenchymal-stem-cells-as-an-appropriate-source-for-skin-tissue-engineering-and-regenerative-medicine
#9
Behrouz Farhadihosseinabadi, Mehrdad Farahani, Tahereh Tayebi, Ameneh Jafari, Felor Biniazan, Khashayar Modaresifar, Hamideh Moravvej, Soheyl Bahrami, Heinz Redl, Lobat Tayebi, Hassan Niknejad
One of the main goals of tissue engineering and regenerative medicine is to develop skin substitutes for treating deep dermal and full thickness wounds. In this regard, both scaffold and cell source have a fundamental role to achieve exactly the same histological and physiological analog of skin. Amnion epithelial and mesenchymal cells possess the characteristics of pluripotent stem cells which have the capability to differentiate into all three germ layers and can be obtained without any ethical concern. Amniotic cells also produce different growth factors, angio-modulatory cytokines, anti-bacterial peptides and a wide range of anti-inflammatory agents which eventually cause acceleration in wound healing...
April 24, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29686919/grinspan-s-syndrome-a-rare-case-with-malignant-transformation
#10
Numan Kökten, Lokman Uzun, Ayşe Serap Karadağ, Tülay Zenginkinet, M Tayyar Kalcıoğlu
Aim: Oral lichen planus (OLP) is one of the common chronic inflammatory, noninfectious, and precancerous oral mucosal diseases that affect the stratified squamous epithelium in adults. Grinspan et al. reported an association of OLP with diabetes mellitus and vascular hypertension and called that Grinspan's syndrome in 1966. We aim to present a case of Grinspan's syndrome with malignant transformation. Case Presentation: A 60-year-old man who presented with a ten-year history of OLP diagnosed clinically and histologically was referred to our otolaryngology department with a painless swallowing in the left buccal mucosa for 3 months...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29686821/acute-effect-of-different-concentrations-of-cayenne-pepper-cataplasm-on-sensory-motor-functions-and-serum-levels-of-inflammation-related-biomarkers-in-healthy-subjects
#11
Nejc Sarabon, Stefan Löfler, Jan Cvecka, Wolfgang Hübl, Sandra Zampieri
Physical medicine therapies are often used in treating widespread musculoskeletal disorders, such as neck and low back pain. Herbal cataplasms containing rubefacient substances, such as Cayenne pepper, or galenic preparations like Munari cataplasm are commonly used as natural medications to treat painful areas. In this paper we show the effects of a 20-min application of Cayenne pepper and kaolin powder cataplasm (CPC) on healthy subjects. Treatment effects were evaluated by cold/hot feeling on visual analogue scale, blood pressure, body temperature, skin light touch sensations, two-point discrimination, and pain threshold to a mechanical stimulus, before and immediately after, 15 min after and 30 min after different concentration of Cayenne pepper in CPC preparation on healthy subjects...
January 12, 2018: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29686772/effects-of-7-mega-tm-500-on-oxidative-stress-inflammation-and-skin-regeneration-in-h-2-o-2-treated-skin-cells
#12
In-Bong Song, Hyejung Gu, Hye-Ju Han, Na-Young Lee, Ji-Yun Cha, Yeon-Kyong Son, Jungkee Kwon
Environmental stimuli can lead to the excessive accumulation of reactive oxygen species (ROS), which is one of the risk factors for premature skin aging. Here, we investigated the protective effects of 7-MEGATM 500 (50% palmitoleic acid, 7-MEGA) against oxidative stress-induced cellular damage and its underlying therapeutic mechanisms in the HaCaT human skin keratinocyte cell line (HaCaT cells). Our results showed that treatment with 7-MEGA prior to hydrogen peroxide (H2 O2 )-induced damage significantly increased the viability of HaCaT cells...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29686677/mir-466a-targeting-of-tgf-%C3%AE-2-contributes-to-foxp3-regulatory-t-cell-differentiation-in-a-murine-model-of-allogeneic-transplantation
#13
William Becker, Mitzi Nagarkatti, Prakash S Nagarkatti
The promise of inducing immunological tolerance through regulatory T cell (Treg) control of effector T cell function is crucial for developing future therapeutic strategies to treat allograft rejection as well as inflammatory autoimmune diseases. In the current study, we used murine allograft rejection as a model to identify microRNA (miRNA) regulation of Treg differentiation from naïve CD4 cells. We performed miRNA expression array in CD4+ T cells in the draining lymph node (dLN) of mice which received syngeneic or allogeneic grafts to determine the molecular mechanisms that hinder the expansion of Tregs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29684613/low-or-excess-levels-of-dietary-cholesterol-impaired-immunity-and-aggravated-inflammation-response-in-young-grass-carp-ctenopharyngodon-idella
#14
Xiao-Zhong Wang, Wei-Dan Jiang, Lin Feng, Pei Wu, Yang Liu, Yun-Yun Zeng, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Xiao-Qiu Zhou
The present study explored the effect of cholesterol on the immunity and inflammation response in the immune organs (head kidney, spleen and skin) of young grass carp (Ctenopharyngodon idella) fed graded levels of dietary cholesterol (0.041-1.526%) for 60 days and then infected with Aeromonas hydrophila for 14 days. The results showed that low levels of cholesterol (1) depressed the innate immune components [lysozyme (LZ), acid phosphatase (ACP), complements and antimicrobial peptides] and adaptive immune component [immunoglobulin M (IgM)], (2) up-regulated the mRNA levels of pro-inflammatory cytokines [interleukin 1β (IL-1β), IL-6, IL-8, IL-12p35, IL-12p40, IL-15, IL-17D, tumor necrosis factor α (TNF-α) and interferon γ2 (IFN-γ2)], partly due to the activated nuclear factor kappa B (NF-κB) signalling, and (3) down-regulated the mRNA levels of anti-inflammatory cytokines [IL-4/13B, IL-10, IL-11, transforming growth factor (TGF)-β1 and TGF-β2], partly due to the suppression of target of rapamycin (TOR) signalling in the immune organs of young grass carp...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684510/the-rodent-tibia-fracture-model-a-critical-review-and-comparison-with-the-complex-regional-pain-syndrome-literature
#15
REVIEW
Frank Birklein, Alaa Ibrahim, Tanja Schlereth, Wade S Kingery
Distal limb fracture is the most common cause of complex regional pain syndrome (CRPS), thus the rodent tibia fracture model (TFM) was developed to study CRPS pathogenesis. This comprehensive review summarizes the published TFM research and compares these experimental results with the CRPS literature. The TFM generated spontaneous and evoked pain behaviors, inflammatory symptoms (edema, warmth) and trophic changes (skin thickening, osteoporosis) resembling symptoms in early CRPS. Neuropeptides, inflammatory cytokines, and nerve growth factor (NGF) have been linked to pain behaviors, inflammation, and trophic changes in the TFM model and proliferating keratinocytes were identified as the primary source of cutaneous cytokines and NGF...
April 20, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29683455/three-dimensional-inflammatory-human-tissue-equivalents-of-gingiva
#16
Li Xiao, Hisashi Okamura, Yasuo Kumazawa
Periodontal diseases (such as gingivitis and periodontitis) are the leading causes of tooth loss in adults. Inflammation in gingiva is the fundamental physiopathology of periodontal diseases. Current experimental models of periodontal diseases have been established in various types of animals. However, the physiopathology of animal models is different from that of humans, making it difficult to analyze cellular and molecular mechanisms and evaluate new medicines for periodontal diseases. Here, we present a detailed protocol for reconstructing human inflammatory tissue equivalents of gingiva (iGTE) in vitro...
April 3, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683293/psoriasis-as-a-cardiovascular-risk-factor-updates-and-algorithmic-approach
#17
Emanuele Cozzani, Gianmarco Rosa, Martina Burlando, Aurora Parodi
Although psoriasis is predominantly a chronic inflammatory skin disorder, it has been known to be associated with cardiovascular disease. Patients with psoriasis, particularly with moderate to severe forms, present an increased rate of cardiovascular mortality, myocardial infarction and stroke. However the pathophysiology of the relationship between psoriasis and cardiovascular risk and comorbidities has not yet completely known. Chronic inflammation may be considered a solid link between psoriasis and related cardiovascular events...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29683286/safety-profile-of-chronic-leg-ulcer-biopsy-a-monocentric-retrospective-series-on-866-patients
#18
Carlotta Baraldi, Lidia Sacchelli, Emi Dika, Martina Lambertini, Cosimo Misciali, Tommaso Bianchi, Pier A Fanti
BACKGROUND: Skin biopsy is an important tool for various skin conditions. However, in the case of leg ulcers, some Authors still consider it highly risky and mandatory only in selected cases. METHODS: To evaluate the rate of adverse events after leg ulcers biopsy in 866 consecutive patients referring to our Wound Care Unit in Bologna from January 2008 to December 2016. Two biopsies were performed (from the border and the centre) by the same dermatologist following a standardized structured protocol...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29682605/dual-affinity-heparin-based-hydrogels-achieve-pro-regenerative-immunomodulation-and-microvascular-remodeling
#19
Molly E Ogle, Jack R Krieger, Liane E Tellier, Jennifer McFaline-Figueroa, Johnna S Temenoff, Edward A Botchwey
The immune response to biomaterial implants critically regulates functional outcomes such as vascularization, transplant integration/survival, and fibrosis. To create "immunologically smart" materials, the host-material response may be engineered to optimize the recruitment of pro-regenerative leukocyte subsets which mature into corresponding wound-healing macrophages. We have recently identified a unique feature of pro-regenerative Ly6Clow monocytes that is a higher expression of both the bioactive lipid receptor sphingosine-1-phosphate receptor 3 (S1PR3) and the stromal derived factor-1α (SDF-1α) receptor CXCR4...
April 9, 2018: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/29682371/colonic-mucosal-ulceration-and-gastrointestinal-bleeding-associated-with-sevelamer-crystal-deposition-in-a-patient-with-end-stage-renal-disease
#20
Sudheer Nambiar, Unnikrishnan Kunjan Pillai, Joe Devasahayam, Tony Oliver, Asha Karippot
End stage renal disease (ESRD) population account for 1.9 per patient year of hospital admissions annually. ESRD population are at increased risk of bleeding secondary to use of anticoagulation during hemodialysis and uremia induced platelet dysfunction. Gastrointestinal bleeding accounts for 3-7% of all deaths in ESRD population. Lower gastrointestinal bleeding refers to blood loss from a site in the gastrointestinal tract distal to the ligament of Treitz. It is usually suspected when a patient complains of hematochezia...
2018: Case Reports in Nephrology
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