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https://www.readbyqxmd.com/read/29458209/dermal-anti-oxidant-anti-inflammatory-and-anti-aging-effects-of-compritol-ato-based-resveratrol-colloidal-carriers-prepared-using-mixed-surfactants
#1
Haidy Abbas, Rabab Kamel, Nesrine El-Sayed
In this study, Compritol ATO-based Resveratrol colloidal carriers (CCCs) were prepared. In most formulae, the use of a binary-mixture of surfactants improved the physicochemical properties. CCC6 (containing P407/P188 as bi-surfactants) attained the highest drug loading, release efficiency during 24 hr and occlusive effect for 48 hr; in addition to, a uniform particle size distribution within the desired range. In-vivo studies were done based on the analysis of anti-oxidant markers [catalase (CAT), reduced glutathione (GSH) and superoxide dismutase (SOD)], anti-inflammatory markers [interleukin 6 (IL-6), interleukin 8 (IL-8) and rat Nuclear factor-kappa B (NF-κB)] and anti-wrinkling markers [matrix metalloproteinase (MMP-1) and Granulocyte-macrophage colony-stimulating factor (GM-CSF)], after UVB-irradiation...
February 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29458120/major-role-for-trpv1-and-insp3r-in-par-2-elicited-inflammatory-mediator-production-in-differentiated-human-keratinocytes
#2
Olivier Gouin, Killian L'Herondelle, Paul Buscaglia, Christelle Le Gall-Ianotto, Réginald Philippe, Nelig Legoux, Olivier Mignen, Virginie Buhé, Raphael Leschiera, Mehdi Sakka, Nathalie Kerfant, Jean-Luc Carré, Raphaele Le Garrec, Luc Lefeuvre, Nicolas Lebonvallet, Laurent Misery
Proteinase-activated receptor-2 (PAR-2) activation in basal keratinocytes stimulates inflammation via the Ca2+ -dependent production of mediators such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and thymic stromal lymphopoietin (TSLP). In this study, we investigated PAR-2 calcium signaling and the consequent production of inflammatory mediators in differentiated human primary keratinocytes (DhPKs). Stimulation with the PAR-2 activating peptide SLIGKV promoted Ca2+ store depletion in both undifferentiated human primary keratinocytes (UhPKs) and DhPKs...
February 16, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29458014/topical-delivery-of-l-theanine-ameliorates-tpa-induced-acute-skin-inflammation-via-downregulating-endothelial-pecam-1-and-neutrophil-infiltration-and-activation
#3
Wei-Jie Zeng, Zhi Tan, Xing-Fei Lai, Ya-Nan Xu, Chun-Lin Mai, Jun Zhang, Zhen-Jia Lin, Xian-Guo Liu, Shi-Li Sun, Li-Jun Zhou
l-theanine, the most abundant free amino acid in tea, has been documented to possess many different bioactive properties through oral or intragastrical delivery. However, little is known about the effect of topical delivery of l-theanine on acute inflammation. In the present study, by using 12-O-tetradecanoylphorbol-13-acetate (TPA, 2.5 μg/ear)-induced ear edema model in mice, we first found that single-dose local pretreatment of l-theanine 30 min before TPA time- and dose-dependently suppressed the increases in both skin thickness and weight...
February 16, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29457402/-clinical-study-on-negative-pressure-closed-drainage-combined-with-vancomycin-loaded-calcium-sulfate-and-autogenous-bone-in-the-treatment-of-chronic-osteomyelitis
#4
Qiang Li, Shi-Feng Song, Wei Zhang, Guo-Zhi Wu, Li-Zhu Liu
OBJECTIVE: To study the clinical effects of negative pressure closed drainage combined with vancomycin loaded calcium sulfate and autogenous bone in the treatment of chronic osteomyelitis. METHODS: From June 2013 to December 2016, there were 35 cases of chronic osteomyelitis patients in our department, including 23 males and 12 females, ranging in age from 11 to 65 years old, with an average of 34 years old. The course of disease ranged from 8 to 46 months, with an average of 26 months...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457272/atopic-dermatitis-in-diverse-racial-and-ethnic-groups-variations-in-epidemiology-genetics-clinical-presentation-and-treatment
#5
REVIEW
Bridget P Kaufman, Emma Guttman-Yassky, Andrew F Alexis
Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects diverse ethnic groups with varying prevalence. Despite a predominance of studies in individuals of European ancestry, AD has been found to occur more frequently in Asian and black individuals than whites. Therefore, an understanding of the unique clinical features of AD in diverse ethnic groups, as well as the differences in genetic polymorphisms that influence susceptibility to AD and response to current therapies, is paramount for management of an increasingly diverse patient population...
February 19, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29457262/handheld-reflectance-confocal-microscopy-dermatoscopy-and-histopathological-correlation-of-common-inflammatory-balanitis
#6
F Lacarrubba, A E Verzì, M Ardigò, G Micali
BACKGROUND: The term balanitis includes a variety of inflammatory skin diseases involving the glans penis whose clinical diagnosis may be challenging. A biopsy is often required to obtain a definitive diagnosis, although it is barely accepted by patients. Reflectance confocal microscopy (RCM), that provides a real-time, en face imaging of the epidermis and upper dermis, is currently utilized for the diagnosis of some neoplastic and inflammatory skin diseases. The aim of this study was to analyze the RCM handheld findings of some common balanitis and to correlate them with dermatoscopy and histopathological features...
February 18, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29457211/acetarsol-suppositories-effective-treatment-for-refractory-proctitis-in-a-cohort-of-patients-with-inflammatory-bowel-disease
#7
Christopher J Kiely, Angela Clark, Joya Bhattacharyya, Gordon W Moran, James C Lee, Miles Parkes
BACKGROUND: Management of proctitis refractory to conventional therapies presents a common clinical problem. The use of acetarsol suppositories, which are derived from organic arsenic, was first described in 1965. Data concerning clinical efficacy and tolerability are very limited. AIM: To examine the efficacy of acetarsol suppositories for the treatment of refractory proctitis. METHODS: A retrospective analysis was performed on patients with inflammatory bowel disease treated with acetarsol suppositories between 2008 and 2014 at Addenbrooke's Hospital, Cambridge, United Kingdom...
February 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29456817/s100a9-aggravates-bleomycin-induced-dermal-fibrosis-in-mice-via-activation-of-erk1-2-mapk-and-nf-%C3%AE%C2%BAb-pathways
#8
Xue Xu, Zhiyong Chen, Xiaoxia Zhu, Dandan Wang, Jun Liang, Cheng Zhao, Xuebing Feng, Jiucun Wang, Hejian Zou, Lingyun Sun
Objectives: This study aims to investigate the pathogenicity and possible mechanisms of S100A9 function in mice models of scleroderma. Materials and Methods: The content of S100A9 in the skin tissues of mice with scleroderma was determined. Different concentrations of bleomycin (BLM) and S100A9 were subcutaneously injected into the backs of mice simultaneously, and then pathological changes in the skin of these mice were monitored. Specifically, the levels of inflammatory cytokines and alpha smooth muscle actin (α-SMA), the activation of extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) pathways, and the expression of the receptor for advanced glycation end-product (RAGE) in the skin were determined...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456710/mechanism-of-apoptosis-induction-associated-with-erk1-2-upregulation-via-goniothalamin-in-melanoma-cells
#9
Suphakorn Tangchirakhaphan, Sukanda Innajak, Sirinun Nilwarangkoon, Nudjaree Tanjapatkul, Wilawan Mahabusrakum, Ramida Watanapokasin
The present study aimed to investigate the effect of goniothalamin on apoptosis induction in the A375 melanoma cell line. Melanoma is a type of skin cancer with increased prevalence and no potential standard treatment. Goniothalamin is a plant, bioactive styrly-lactone, which has various bioactivities including anti-microbial, anti-inflammatory and anti-cancer. Apoptosis induction by goniothalamin has been studied in numerous cancer cell lines, however not in the melanoma cell line A375. The results of the MTT assay demonstrated that goniothalamin induced anti-proliferation in a dose dependent manner...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455895/childhood-trauma-and-resilience-in-psoriatic-patients-a-preliminary-report
#10
Maria Luigia Crosta, Clara De Simone, Salvatore Di Pietro, Mariateresa Acanfora, Giacomo Caldarola, Lorenzo Moccia, Antonino Callea, Isabella Panaccione, Ketty Peris, Lucio Rinaldi, Luigi Janiri, Marco Di Nicola
AIMS: Psoriasis is a chronic inflammatory skin disease with a complex etiology, involving the immune system, genetic factors, and external/internal triggers, with psychosomatic aspects. The aim of the study was to investigate childhood trauma and resilience in a psoriatic sample compared with healthy controls. Correlations between childhood trauma, resilience, quality of life, clinical data and psoriatic features were also evaluated. METHODS: Seventy-seven psoriatic patients and seventy-six homogeneous healthy controls were enrolled...
March 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29455854/pathophysiology-and-management-of-mild-to-moderate-pediatric-atopic-dermatitis
#11
Kammi Yap Sayaseng, Peggy Vernon
Atopic dermatitis (AD), or eczema, is a chronic inflammatory skin condition characterized by relapsing pruritic and dry, scaly lesions. AD affects 10% to 20% of children in the United States and significantly affects the quality of life of patients and their families. Primary care providers (PCPs) are often the first point of contact for the management of AD symptoms. As many as 70% of patients with mild to moderate disease can be managed by a PCP, underscoring the need for these providers to understand basic AD pathophysiology and current standards of care...
March 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29455850/proteins-involved-in-the-antioxidant-and-inflammatory-response-in-rutin-treated-human-skin-fibroblasts-exposed-to-uva-or-uvb-irradiation
#12
Agnieszka Gęgotek, Pedro Domingues, Elżbieta Skrzydlewska
BACKGROUND: Rutin, due to its polyphenolic structure, has antioxidant properties and can be used as a cytoprotective compound against UV-induced effects on skin cells. OBJECTIVE: The aim of this study was to examine the effect of rutin on proteomic profile in human skin fibroblasts irradiated with UV dose that induces apoptosis. METHODS: Proteome analysis based on the results obtained by the QExactive OrbiTrap mass spectrometer. RESULTS: Results show that rutin treatment more strongly protects against UVA-induced rather than UVB-induced increases in the total expression of proteins involved in antioxidant (such as SOD, TrxR, and Prxs 1/2) and inflammatory response (e...
February 15, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29455734/bamboo-salt-suppresses-skin-inflammation-in-mice-with-2-4-dinitrofluorobenzene-induced-atopic-dermatitis
#13
Myoung-Schook Yoou, Sun-Young Nam, Kyoung Wan Yoon, Hyun-Ja Jeong, Hyung-Min Kim
Bamboo salt (BS) is a traditional Korean food, and has been reported to have anti-cancer, anti-inflammatory, and anti-metastatic effects. However, the anti-atopic dermatitis (AD) activity of BS has not been described yet. In the present study, we examined the preventive effect of BS on AD. The effect of oral administration of BS was tested in a 2, 4-dinitrofluorobenzene (DNFB)-induced AD animal model, by histological analysis, enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, caspase-1 assay, and Western blotting analysis...
February 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29454952/probing-the-interaction-of-the-phytochemical-6-gingerol-from-the-spice-ginger-with-dna
#14
Poovvathingal Haris, Varughese Mary, Chellappanpillai Sudarsanakumar
6-Gingerol [5-hydroxy-1-(4-hydroxy-3-methoxyphenyl) decan-3-one], the bio-active ingredient of the popular Indian spice ginger (Zingiber officinale Roscoe), is well-known for its pharmacological and physiological actions. The potent antioxidant, antiemetic, antiulcer, antimicrobial, analgesic, hypoglycemic, antihypertensive, antihyperlipidemic, immunostimulant, anti-inflammatory, cardiotonic, and cancer prevention activities of 6-Gingerol has been investigated and explored. 6-Gingerol is a good candidate for the treatment of various cancers including prostrate, pancreatic, breast, skin, gastrointestinal, pulmonary, and renal cancer...
February 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454836/mechanism-for-initiation-of-food-allergy-dependence-on-skin-barrier-mutations-and-environmental-allergen-co-stimulation
#15
Matthew Walker, Jeremy Green, Ryan Ferrie, Ashley Queener, Mark H Kaplan, Joan M Cook-Mills
BACKGROUND: Mechanisms for the development of food allergy in neonates are unknown but are clearly linked in patient populations to a genetic predisposition towards skin barrier defects. Whether skin barrier defects functionally contribute to development of food allergy is unknown. OBJECTIVE: The purpose of the study was to determine whether skin barrier mutations, that are primarily heterozygous in patient populations, contribute to the development of food allergy...
February 15, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29454750/a-newly-discovered-antifibrotic-pathway-regulated-by-two-fatty-acid-receptors-gpr40-and-gpr84
#16
Lyne Gagnon, Martin Leduc, Jean-Francois Thibodeau, Ming-Zhi Zhang, Brigitte Grouix, Francois Sarra-Bournet, William Gagnon, Kathy Hince, Mikaël Tremblay, Lilianne Geerts, Christopher R J Kennedy, Richard L Hébert, Alex Gutsol, Chet E Holterman, Eldjonai Kamto, Liette Gervais, Jugurtha Ouboudinar, Jonathan Richard, Alexandra Felton, Alexandre Laverdure, Jean-Christophe Simard, Sylvie Létourneau, Marie-Pier Cloutier, Francois A Leblond, Shaun D Abbott, Christopher Penney, Jean-Simon Duceppe, Boulos Zacharie, Jocelyn Dupuis, Angelino Calderone, Quang Trinh Nguyen, Raymond C Harris, Pierre Laurin
Numerous clinical conditions can lead to organ fibrosis and functional failure. There is a great need for therapies that could effectively target pathophysiological pathways involved in fibrosis. GPR40 and GPR84 are G protein-coupled receptors with free fatty acid ligands and are associated with metabolic and inflammatory disorders. Although GPR40 and GPR84 are involved in diverse physiological processes, no evidence has demonstrated the relevance of GPR40 and GPR84 in fibrosis pathways. Using PBI-4050 (3-pentylbenzeneacetic acid sodium salt), a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively, we uncovered an antifibrotic pathway involving these receptors...
February 15, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29454062/laser-assisted-delivery-of-synergistic-combination-chemotherapy-in-in-vivo-skin
#17
Emily Wenande, Joshua Tam, Brijesh Bhayana, Steven Kyle Schlosser, Emily Ishak, William A Farinelli, Agata Chlopik, Mai P Hoang, Omar R Pinkhasov, Peter Caravan, R Rox Anderson, Merete Haedersdal
The effectiveness of topical drugs for treatment of non-melanoma skin cancer is greatly reduced by insufficient penetration to deep skin layers. Ablative fractional lasers (AFLs) are known to enhance topical drug uptake by generating narrow microchannels through the skin, but information on AFL-drug delivery in in vivo conditions is limited. In this study, we examined pharmacokinetics, biodistribution and toxicity of two synergistic chemotherapy agents, cisplatin and 5-fluorouracil (5-FU), following AFL-assisted delivery alone or in combination in in vivo porcine skin...
February 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29453874/outcomes-of-early-dermatology-consultation-for-inpatients-diagnosed-with-cellulitis
#18
David G Li, Fan Di Xia, Hasan Khosravi, Anna K Dewan, Daniel J Pallin, Christopher W Baugh, Karl Laskowski, Cara Joyce, Arash Mostaghimi
Importance: Many inflammatory skin dermatoses mimic cellulitis (pseudocellulitis) and are treated with antibiotics and/or hospitalization, leading to unnecessary patient morbidity and substantial health care spending. Objective: To evaluate the impact of early dermatology consultation on clinical and economic outcomes associated with misdiagnosed cellulitis. Design, Setting, and Participants: This prospective cohort study enrolled patients with presumed diagnosis of cellulitis in the emergency department, in the emergency department observation unit, or within 24 hours of admission to an inpatient unit of a large urban teaching hospital between February and September 2017...
February 16, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29451596/histopathological-characteristics-of-cutaneous-lesions-caused-by-leishmania-viannia-panamensis-in-panama
#19
Kadir González, Rosendo Diaz, Aurea F Ferreira, Víctor García, Héctor Paz, José E Calzada, Michelle Ruíz, Márcia Laurenti, Azael Saldaña
Cutaneous leishmaniasis (CL) is an endemic disease in the Republic of Panama, caused by Leishmania (Viannia) parasites, whose most common clinical manifestation is the presence of ulcerated lesions on the skin. These lesions usually present a chronic inflammatory reaction, sometimes granulomatous, with the presence of lymphocytes, plasma cells and macrophages. This study describes the histopathological characteristics found in the skin lesions of patients with CL caused by Leishmania (V.) panamensis in Panama...
2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29450882/the-role-of-neutrophils-in-skin-damage-induced-by-tissue-deposited-lupus-igg
#20
Xuanxuan Guo, Xiang Fang, Guodan He, M Haidar Zaman, Xibin Fei, Wei Qiao, Guo-Min Deng
Skin injury is the second most common clinical manifestation in patients with SLE. Neutrophils are crucial effector cells in immune system. The significance of neutrophils in the pathogenesis of SLE is not clear. This study is to explore the role of neutrophils in skin damage of SLE. We used lupus-prone mice and C57BL/6 mice model of lupus serum IgG induced skin inflammation to investigate neutrophils role in skin damage of SLE. We found a few neutrophils infiltrated in the inflammatory sites of skin in lupus-prone mice and lupus IgG induced skin damaged mice model...
February 16, 2018: Immunology
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