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Spleen segment

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https://www.readbyqxmd.com/read/28614785/drag-reducing-polymers-decrease-hepatic-injury-and-metastases-after-liver-ischemia-reperfusion
#1
Samer Tohme, Marina V Kameneva, Hamza O Yazdani, Vikas Sud, Julie Goswami, Patricia Loughran, Hai Huang, Richard L Simmons, Allan Tsung
INTRODUCTION: Surgery, a crucial therapeutic modality in the treatment of solid tumors, can induce sterile inflammatory processes which can result in metastatic progression. Liver ischemia and reperfusion (I/R) injury, an inevitable consequence of hepatic resection of metastases, has been shown to foster hepatic capture of circulating cancer cells and accelerate metastatic growth. Efforts to reduce these negative consequences have not been thoroughly investigated. Drag reducing polymers (DRPs) are blood-soluble macromolecules that can, in nanomolar concentrations, increase tissue perfusion, decrease vascular resistance and decrease near-wall microvascular concentration of neutrophils and platelets thereby possibly reducing the inflammatory microenvironment...
May 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28570262/automatized-spleen-segmentation-in-non-contrast-enhanced-mr-volume-data-using-subject-specific-shape-priors
#2
Oliver Gloger, Klaus Tönnies, Robin Bülow, Henry Voelzke
To develop the first fully automated 3D spleen segmentation framework derived from T1-weighted magnetic resonance (MR) imaging data; and to verify its performance for spleen delineation and volumetry. This approach considers the issue of low contrast between spleen and adjacent tissue in non-contrast-enhanced MR images. Materials and Methods: Native T1-weighted MR volume data was performed on a 1.5 Tesla MR system in an epidemiological study. We analyzed random subsamples of MR examinations without pathologies to develop and verify the spleen segmentation framework...
June 1, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28542307/the-mouse-char10-locus-regulates-severity-of-pyruvate-kinase-deficiency-and-susceptibility-to-malaria
#3
Aurélie Laroque, Gundula Min-Oo, Mifong Tam, Prem Ponka, Mary M Stevenson, Philippe Gros
Pyruvate kinase (PKLR) deficiency protects mice and humans against blood-stage malaria. Although mouse strain AcB62 carries a malaria-protective PklrI90N genetic mutation, it is phenotypically susceptible to blood stage malaria induced by infection with Plasmodium chabaudi AS, suggesting a genetic modifier of the PklrI90N protective effect. Linkage analysis in a F2 cross between AcB62 (PklrI90N) and another PK deficient strain CBA/Pk (PklrG338D) maps this modifier (designated Char10) to chromosome 9 (LOD = 10...
2017: PloS One
https://www.readbyqxmd.com/read/28537566/intramural-gastric-hematoma-imitating-a-gastrointestinal-stromal-tumor-case-report-and-literature-review
#4
Arkadiusz Spychała, Piotr Nowaczyk, Aleksandra Budnicka, Ewa Antoniewicz, Dawid Murawa
The article presents a case report of a patient with an intramural gastric hematoma. Diagnostic examinations were suggestive of a suspected gastrointestinal stromal tumor Normal image was observed in gastroscopic examination while abdominal CT scan revealed a nodular lesion along the greater curvature of the stomach extending from the posterior wall and adjoining the pancreas and the spleen. The patient was qualified for surgical treatment. Laparotomy was performed followed by total gastric resection and Roux-en-Y reconstruction of the gastrointestinal tract...
April 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28534802/organ-location-determination-and-contour-sparse-representation-for-multi-organ-segmentation
#5
Siqi Li, Huiyan Jiang, Yu-Dong Yao, Benqiang Yang
Organ segmentation on computed tomography (CT) images is of great importance in medical diagnoses and treatment. This paper proposes organ location determination and contour sparse representation methods (OLD-CSR) for multiorgan segmentation (liver, kidney, and spleen) on abdomen CT images using an extreme learning machine (ELM) classifier. First, a location determination method is designed to obtain location information of each organ, which is used for coarse segmentation. Second, for coarse-to-fine segmentation, a contour gradient and rate change based feature point extraction method is proposed...
May 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28529633/noninvasive-assessment-of-elimination-and-retention-using-ct-fmt-and-kinetic-whole-body-modeling
#6
Wa'el Al Rawashdeh, Simin Zuo, Andrea Melle, Lia Appold, Susanne Koletnik, Yoanna Tsvetkova, Nataliia Beztsinna, Andrij Pich, Twan Lammers, Fabian Kiessling, Felix Gremse
Fluorescence-mediated tomography (FMT) is a quantitative three-dimensional imaging technique for preclinical research applications. The combination with micro-computed tomography (µCT) enables improved reconstruction and analysis. The aim of this study is to assess the potential of µCT-FMT and kinetic modeling to determine elimination and retention of typical model drugs and drug delivery systems. We selected four fluorescent probes with different but well-known biodistribution and elimination routes: Indocyanine green (ICG), hydroxyapatite-binding OsteoSense (OS), biodegradable nanogels (NG) and microbubbles (MB)...
2017: Theranostics
https://www.readbyqxmd.com/read/28480681/the-role-of-liver-segment-to-spleen-volume-ratio-in-the-staging-of-hepatic-fibrosis-in-patients-with-hepatitis-c-virus-infection
#7
Eyal Lotan, Stephen P Raskin, Michal M Amitai, Yeruham Kleinbaum, Ella Veitsman, Peretz Weiss, Oranit Cohen-Ezra, Tania Berdichevski, Ziv Ben-Ari
BACKGROUND: Accurate assessment of liver fibrosis is crucial for the management of patients with hepatitis C virus (HCV) infection. OBJECTIVES: To evaluate the performance of liver segment-to-spleen volume ratio in predicting the severity of liver fibrosis. METHODS: Sixty-four consecutive HCV patients were enrolled in this retrospective study. All patients underwent contrast-enhanced computed tomography (CT) and were divided into three groups based on their hepatic fibrosis stage evaluated by shear-wave elastography (SWE): non-advanced (F0-F1, n=29), advanced (F2, n=19) and severe fibrosis (F3-F4, n=16)...
April 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28433992/the-aachen-minipig-phenotype-genotype-hematological-and-biochemical-characterization-and-comparison-to-the-g%C3%A3-ttingen-minipig
#8
Kerstin Pawlowsky, Lisa Ernst, Julia Steitz, Thaddäus Stopinski, Babette Kögel, Anna Henger, Reinhart Kluge, René Tolba
BACKGROUND: The pig is one of the most frequently used large animal models for biomedical research, especially in the field of translational research and surgical models. While standard livestock breeds are used in short-term and acute studies, minipig breeds are the preferred breeds in long-term and chronic studies due to their limited growth and body weight. OBJECTIVE: In consideration of the 3R principle (refinement, reduction, replacement) and the increasing demand, the aim of this study was to generate a new, robust, non-specific-pathogen-free minipig breed, the Aachen minipig...
April 22, 2017: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/28395109/anatomo-radiological-patterns-of-pancreatic-vascularization-with-surgical-implications-clinical-and-anatomical-study
#9
Veronica Macchi, Edgardo Enrico Edoardo Picardi, Andrea Porzionato, Aldo Morra, Romeo Bardini, Marios Loukas, R Shane Tubbs, Raffaele De Caro
The pancreas receives multiple arterial sources that should be considered in patients undergoing pancreatic surgery. The aim of this study is to describe pancreatic vascularization and to explore the anatomical basis of postoperative complications. Ten specimens from unembalmed cadavers, including the retroperitoneal vessels and organs and spleen, were injected with acrylic resins to obtain vascular casts. Thirty computed tomography angiographies (CTA) of subjects with no pancreatic pathology (mean age 70.9 years) were also analyzed...
April 10, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28352993/preclinical-evaluation-of-the-short-term-toxicity-of-4-n-docosahexaenoyl-2%C3%A2-2%C3%A2-difluorodeoxycytidine-dha-dfdc
#10
Solange Valdes, Youssef W Naguib, Rick A Finch, Wallace B Baze, Christopher A Jolly, Zhengrong Cui
PURPOSE: This study was designed to test the short-term toxicity of DHA-dFdC in a mouse model and its efficacy in a mouse model of leukemia at or below its repeat-dose maximum tolerated dose (RD-MTD). METHOD: A repeat-dose dose-ranging toxicity study was designed to determine the tolerability of DHA-dFdC when administered to DBA/2 mice by intravenous (i.v.) injection on a repeat-dose schedule (i.e. injections on days 0, 3, 7, 10, and 13). In order to determine the effect of a lethal dose of DHA-dFdC, mice were injected i...
June 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28322993/intra-luminal-gene-therapy-in-the-porcine-artery-using-a-recombinant-adeno-associated-virus-9
#11
E S Rezaie, N J Visser, P F Friedrich, A Y Shin, A T Bishop
The ability to improve or restore blood flow and promote healing in ischemic tissue has many potential clinical applications. Augmentation by direct delivery of growth factors may further enhance results, but requires a method for sustained delivery. In this study, we have tested the ability of adeno-associated virus 9 (AAV9) delivered within the lumen of a porcine artery to transfect the vessel and produce a desired product. The marker chosen was green fluorescent protein (GFP) (Ke et al., 2011). In 4 farm pigs the cranial tibial artery was surgically exposed...
June 30, 2017: Gene
https://www.readbyqxmd.com/read/28306547/synthetic-ct-for-mri-based-liver-stereotactic-body-radiotherapy-treatment-planning
#12
Jeremy S Bredfeldt, Lianli Liu, Mary Feng, Yue Cao, James M Balter
A technique for generating MRI-derived synthetic CT volumes (MRCTs) is demonstrated in support of adaptive liver stereotactic body radiation therapy (SBRT). Under IRB approval, 16 subjects with hepatocellular carcinoma were scanned using a single MR pulse sequence (T1 Dixon). Air-containing voxels were identified by intensity thresholding on T1-weighted, water and fat images. The envelope of the anterior vertebral bodies was segmented from the fat image and fuzzy-C-means (FCM) was used to classify each non-air voxel as mid-density, lower-density, bone, or marrow in the abdomen, with only bone and marrow classified within the vertebral body envelope...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28286647/investigation-of-the-immune-effects-of-scutellaria-baicalensis-on-blood-leukocytes-and-selected-organs-of-the-chicken-s-lymphatic-system
#13
Bożena Króliczewska, Stanisław Graczyk, Jarosław Króliczewski, Aleksandra Pliszczak-Król, Dorota Miśta, Wojciech Zawadzki
BACKGROUND: The health of chickens and the welfare of poultry industry are central to the efforts of addressing global food security. Therefore, it is essential to study chicken immunology to maintain and improve its health and to find novel and sustainable solutions. This paper presents a study on investigation of the effect of Scutellaria baicalensis root (SBR) on the immune response of broiler chicken, especially on lymphocytes and heterophils reactivity, regarding their contribution to the development of immunity of the chickens...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28258903/comparative-evaluation-of-three-software-packages-for-liver-and-spleen-segmentation-and-volumetry
#14
Puskar Pattanayak, Evrim B Turkbey, Ronald M Summers
RATIONALE AND OBJECTIVES: This study aims to compare the speed and accuracy of three different software packages in segmenting the liver and the spleen. MATERIALS AND METHODS: The three software packages are Advantage Workstation Solutions (AWS), Claron Technology (Claron) Liver Segmentor, and Vitrea Core Fx (Vitrea). The dataset consisted of abdominal computed tomography scans of 30 patients obtained from the portal venous phase. All but two of the patients had a cancer diagnosis...
February 28, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28197897/middle-segment-preserving-pancreatectomy-for-metachronous-intraductal-papillary-mucinous-neoplasm-after-pancreatoduodenectomy-a-case-report
#15
Mihoko Yamada, Teiichi Sugiura, Yukiyasu Okamura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhiko Uesaka
Total pancreatectomy has occasionally been performed to treat patients with multiple lesions (such as intraductal papillary mucinous neoplasm (IPMN)) or patients who have undergone repeated pancreatic resection. However, deficiencies of the exocrine and endocrine functions worsen patients' quality of life. Recently, there have been several case reports citing middle segment-preserving pancreatectomy (MSPP) as a safe procedure and beneficial with respect to preservation of the exocrine and endocrine functions...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28125922/ace-inhibitor-induced-angioedema-of-the-small-bowel
#16
Kent L Wilin, Michael J Czupryn, Richard Mui, Anas Renno, Julie A Murphy
Angiotensin-converting enzyme (ACE) inhibitors are known to cause angioedema. Most ACE inhibitor-induced angioedema cases describe swelling in the periorbital region, tongue, and pharynx. We describe a case of a 62-year-old female with presumed angioedema of the small bowel after more than a 2-year history of lisinopril use (with no recent changes in her dose of 40 mg orally twice daily). The patient presented with nausea and intermittent left middle and upper quadrant abdominal pain and denied history of angioedema or swelling with any medications or any history of abdominal pain...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28112399/estimating-organ-doses-from-tube-current-modulated-ct-examinations-using-a-generalized-linear-model
#17
Maryam Bostani, Kyle McMillan, Peiyun Lu, Grace Hyun J Kim, Dianna Cody, Gary Arbique, S Bruce Greenberg, John J DeMarco, Chris H Cagnon, Michael F McNitt-Gray
PURPOSE: Currently, available Computed Tomography dose metrics are mostly based on fixed tube current Monte Carlo (MC) simulations and/or physical measurements such as the size specific dose estimate (SSDE). In addition to not being able to account for Tube Current Modulation (TCM), these dose metrics do not represent actual patient dose. The purpose of this study was to generate and evaluate a dose estimation model based on the Generalized Linear Model (GLM), which extends the ability to estimate organ dose from tube current modulated examinations by incorporating regional descriptors of patient size, scanner output, and other scan-specific variables as needed...
April 2017: Medical Physics
https://www.readbyqxmd.com/read/28111438/effect-of-sodium-butyrate-on-performance-immune-status-microarchitecture-of-small-intestinal-mucosa-and-lymphoid-organs-in-broiler-chickens
#18
Arbab Sikandar, Hafsa Zaneb, Muhammad Younus, Saima Masood, Asim Aslam, Farina Khattak, Saima Ashraf, Muhammad Shahbaz Yousaf, Habib Rehman
OBJECTIVE: This study aimed to examine the effect of sodium butyrate (SB) on growth performance, immune status, organs weights, and microarchitecture of lymphoid organs and small intestine. METHODS: A total of 120, 1-d-old broiler chicks were distributed into the following four treatment groups: corn-soy based basal diet (BD) without supplement (control), or the same BD supplemented with 0.1 g/kg zinc bacitracin (ZnB), 0.5 g/kg SB (SB-0.5), or 1.0 g/kg SB (SB-1), respectively...
May 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28063951/transcriptomic-analysis-of-spleen-infected-with-infectious-salmon-anemia-virus-reveals-distinct-pattern-of-viral-replication-on-resistant-and-susceptible-atlantic-salmon-salmo-salar
#19
Phillip Dettleff, Thomas Moen, Nina Santi, Victor Martinez
The infectious salmon anemia virus (ISAv) produces a systemic infection in salmonids, causing large losses in salmon production. However, little is known regarding the mechanisms exerting disease resistance. In this paper, we perform an RNA-seq analysis in Atlantic salmon challenged with ISAv (using individuals coming from families that were highly susceptible or highly resistant to ISAv infection). We evaluated the differential expression of both host and ISAv genes in a target organ for the virus, i.e. the spleen...
February 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28060917/a-novel-mouse-segmentation-method-based-on-dynamic-contrast-enhanced-micro-ct-images
#20
Dongmei Yan, Zhihong Zhang, Qingming Luo, Xiaoquan Yang
With the development of hybrid imaging scanners, micro-CT is widely used in locating abnormalities, studying drug metabolism, and providing structural priors to aid image reconstruction in functional imaging. Due to the low contrast of soft tissues, segmentation of soft tissue organs from mouse micro-CT images is a challenging problem. In this paper, we propose a mouse segmentation scheme based on dynamic contrast enhanced micro-CT images. With a homemade fast scanning micro-CT scanner, dynamic contrast enhanced images were acquired before and after injection of non-ionic iodinated contrast agents (iohexol)...
2017: PloS One
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