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https://www.readbyqxmd.com/read/29224020/association-between-glcci1-promoter-polymorphism-rs37972-and-post-transplant-hypertension-in-renal-transplant-recipients
#1
Aki Mafune Hamada, Izumi Yamamoto, Yasuyuki Nakada, Akimitsu Kobayashi, Yusuke Koike, Jun Miki, Hiroki Yamada, Yudo Tanno, Ichiro Ohkido, Nobuo Tsuboi, Hiroyasu Yamamoto, Mitsuyoshi Urashima, Takashi Yokoo
BACKGROUND/AIMS: Post-transplant hypertension is highly prevalent in renal transplant recipients and is a risk factor for graft loss, cardiovascular disease and death. Glucocorticoid is used to prevent rejection, but simultaneously increases the risk of post-transplant hypertension. The glucocorticoid-induced transcript 1 (GLCCI1) promoter polymorphism (rs37972) has been reported to be associated with response to glucocorticoid therapy in asthma. We therefore examined the association between GLCCI1 promoter polymorphism and post-transplant hypertension in renal transplant recipients...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29223554/oral-administration-of-nigella-sativa-oil-and-thymoquinone-attenuates-long-term-cisplatin-treatment-induced-toxicity-and-oxidative-damage-in-rat-kidney
#2
Zeba Farooqui, Faaiza Shahid, Aijaz Ahmed Khan, Farah Khan
Cisplatin (CP) is an effective anti-cancer drug which causes remarkable toxicity to the kidney, particularly to proximal tubules, by generating reactive oxygen species. Nigella sativa (NS), commonly known as "black cumin" reduces the progression of various kidney disorders. Thymoquinone (TQ), the major bioactive constituent of NS seeds, has been credited for various pharmacological effects of NS. Since, a typical clinical CP dosing regimen involves CP administration in multiple cycles over a long time duration, hence the present study aimed to evaluate the renoprotective efficacy of NS oil and TQ against multiple dose CP treatment induced deleterious biochemical and histological alterations in rat kidney...
December 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29222397/indoxyl-sulfate-upregulates-liver-p-glycoprotein-expression-and-activity-through-aryl-hydrocarbon-receptor-signaling
#3
Tacy Santana Machado, Stéphane Poitevin, Pascale Paul, Nathalie McKay, Noémie Jourde-Chiche, Tristan Legris, Annick Mouly-Bandini, Françoise Dignat-George, Philippe Brunet, Rosalinde Masereeuw, Stéphane Burtey, Claire Cerini
In patients with CKD, not only renal but also, nonrenal clearance of drugs is altered. Uremic toxins could modify the expression and/or activity of drug transporters in the liver. We tested whether the uremic toxin indoxyl sulfate (IS), an endogenous ligand of the transcription factor aryl hydrocarbon receptor, could change the expression of the following liver transporters involved in drug clearance: SLC10A1, SLC22A1, SLC22A7, SLC47A1, SLCO1B1, SLCO1B3, SLCO2B1, ABCB1, ABCB11, ABCC2, ABCC3, ABCC4, ABCC6, and ABCG2 We showed that IS increases the expression and activity of the efflux transporter P-glycoprotein (P-gp) encoded by ABCB1 in human hepatoma cells (HepG2) without modifying the expression of the other transporters...
December 8, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29221978/influence-of-6-hydroxyethyl-starch-130-0-4-versus-crystalloid-solution-on-structural-renal-damage-markers-after-coronary-artery-bypass-grafting-a-post-hoc-subgroup-analysis-of-a-prospective-trial
#4
Thomas Datzmann, Markus Hoenicka, Helmut Reinelt, Andreas Liebold, Hagen Gorki
OBJECTIVE: The restriction of hydroxyethyl starch (HES) has mandated changes in volume management based on data of critically ill patients. Reliable data of structural renal damage after HES treatment in cardiac surgical patients are lacking. The influence of 6% HES 130/0.4 was investigated in this study. DESIGN: An exploratory post hoc subgroup analysis of a prospective trial was performed. SETTING: The study was carried out at a university hospital...
May 25, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29219791/effects-of-the-vitamin-d-analog-2amd-in-cyclosporine-induced-nephrotoxicity-dose-response-and-antifibrotic-activity
#5
Bianca Tomasini-Johansson, Cori O'Brien, Alexandra Larson-Osborne, Inger Toraason, Debra Hullett, Lori Plum, Hector DeLuca, Hans Sollinger
OBJECTIVES: In this study, we aimed to ascertain the efficacy and determine the dose effects of a new analog of vitamin D, 2α-methyl-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2AMD), in decreasing fibrosis and improving renal function in a rat model of kidney disease. MATERIALS AND METHODS: Using the cyclosporine model of chronic kidney disease, we tested 4 dose regimens (2.5, 5, 10, and 20 ng/kg) of 2AMD by subcutaneous administration. The 2AMD analog was compared with another analog, 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD), given at 5 ng/kg...
December 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29217888/nutcracker-syndrome-with-hypertension-as-an-unusual-initial-presentation
#6
N A Narkhede, A B Deokar, K P Mehta, N N Kamat
Hypertension has been rarely reported in patients with the nutcracker phenomenon (NCP)/syndrome. We describe a case of a young adolescent female patient where a computed tomography angiography (CTA) provided evidence of left renal vein dilatation, probably due to its compression through the angle between the aorta and the superior mesenteric artery, during the evaluation of secondary hypertension. Blood levels of renin and aldosterone were within normal limits. Ultrasonography of the kidney showed minimal scarring on the left side...
November 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29217759/opposing-roles-of-dendritic-cell-subsets-in-experimental-gn
#7
Sebastian Brähler, Bernd H Zinselmeyer, Saravanan Raju, Maximilian Nitschke, Hani Suleiman, Brian T Saunders, Michael W Johnson, Alexander M C Böhner, Susanne F Viehmann, Derek J Theisen, Nicole M Kretzer, Carlos G Briseño, Konstantin Zaitsev, Olga Ornatsky, Qing Chang, Javier A Carrero, Jeffrey B Kopp, Maxim N Artyomov, Christian Kurts, Kenneth M Murphy, Jeffrey H Miner, Andrey S Shaw
Dendritic cells (DCs) are thought to form a dendritic network across barrier surfaces and throughout organs, including the kidney, to perform an important sentinel function. However, previous studies of DC function used markers, such as CD11c or CX3CR1, that are not unique to DCs. Here, we evaluated the role of DCs in renal inflammation using a CD11c reporter mouse line and two mouse lines with DC-specific reporters, Zbtb46-GFP and Snx22-GFP. Multiphoton microscopy of kidney sections confirmed that most of the dendritically shaped CD11c+ cells forming a network throughout the renal interstitium expressed macrophage-specific markers...
December 7, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29217733/sex-as-a-biological-variable-in-preclinical-imaging-research-initial-observations-with-18f-fluorothymidine
#8
Szeman Ruby Chan, Kelley Salem, Justin Jeffery, Ginny L Powers, Yongjun Yan, Kooresh I Shoghi, Aparna M Mahajan, Amy M Fowler
The study objective was to investigate whether sex influences 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) uptake and tissue distribution in mouse models of cancer. Methods:18F-FLT biodistribution was measured in three strains of male and female mice (129S6/SvEv, athymic nude, and BALB/c). 18F-Fluoro-2-deoxy-2-D-glucose (18F-FDG) biodistribution was performed for comparison. 18F-FLT uptake was also measured in female 129S6/SvEv mice bearing estrogen-dependent SSM3 mouse mammary tumors, male athymic nude mice bearing androgen-dependent CWR22 prostate cancer xenografts, and male and female athymic nude mice bearing estrogen-independent MDA-MB-231 human breast cancer xenografts...
December 7, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29217496/protective-action-of-crtaeva-nurvala-buch-ham-extracts-against-renal-ischaemia-reperfusion-injury-in-rats-via-antioxidant-and-anti-inflammatory-activities
#9
Mouchira Aly Choucry, Mohammed N A Khalil, Sally A El Awdan
ETHNOPHARMACOLOGICAL RELEVANCE: Crateva nurvala stem bark is commonly used in Ayruveda in treatment of many renal injuries, e.g., urinary lithiasis, diuretic and nephroprotective. However, its protective effect against renal ischaemia/reperfusion, the major cause of acute kidnea injury, has never been studied. Moreover, no comprehensive chemical profiling of its extracts was recorded. AIM OF THE STUDY: Assessment of the protective effect of both extracts against renal ischaemia/reperfusion and elucidation of the possible mechanism of action...
December 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29216937/-significance-of-peripheral-perfusion-index-in-early-diagnosis-and-goal-directed-therapy-of-septic-shock-patients-a-prospective-single-blind-randomized-controlled-trial
#10
Yuanfeng Shi, Ruihong Yin, Yanli Wang, Jiguang Li, Xiaobing Chen, Yongpeng Xie, Caihong Gu, Xiuzhen Zou, Kexi Liu
OBJECTIVE: To investigate the application of peripheral perfusion index (PPI) in early diagnosis and goal-directed therapy of septic shock, and to provide reference for the early clinical diagnosis and treatment of septic shock. METHODS: A prospective single-blind randomized controlled trial (RCT) was conducted. Adult patients with sepsis admitted to emergency medical department and intensive care unit (ICU) of the First People's Hospital of Lianyungang City in Jiangsu Province from January 2013 to December 2016 were enrolled...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29215461/influence-of-blood-pressure-and-calcineurin-inhibitors-on-kidney-function-after-heart-or-liver-transplantation
#11
Christian Morath, Gerhard Opelz, Bernd Döhler, Martin Zeier, Caner Süsal
BACKGROUND: Chronic kidney disease is common after heart or liver transplantation, with calcineurin inhibitors (CNI) considered the key contributor. A possible influence of posttransplant blood pressure has not been extensively examined. METHODS: Data from adult recipients of a first heart or liver transplant were analyzed regarding the relationship between blood pressure at year 1, renal function at year 5, and CNI therapy. RESULTS: Whereas we confirmed the well-known detrimental effect of increased 1-year systolic blood pressure on 5-year kidney graft survival, heart or liver graft survival were not affected...
December 5, 2017: Transplantation
https://www.readbyqxmd.com/read/29214868/sulfasalazine-induces-mitochondrial-dysfunction-and-renal-injury
#12
Hossein Niknahad, Reza Heidari, Roya Mohammadzadeh, Mohammad Mehdi Ommati, Forouzan Khodaei, Negar Azarpira, Narges Abdoli, Mahdi Zarei, Behnam Asadi, Maryam Rasti, Babak Shirazi Yeganeh, Vahid Taheri, Arastoo Saeedi, Asma Najibi
Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases of renal injury encompass sulfasalazine administration in humans. The mechanism of sulfasalazine adverse effects toward kidneys is obscure. Oxidative stress and its consequences seem to play a role in the sulfasalazine-induced renal injury. The current investigation was designed to investigate the effect of sulfasalazine on kidney mitochondria. Rats received sulfasalazine (400 and 600 mg/kg/day, oral) for 14 consecutive days...
November 2017: Renal Failure
https://www.readbyqxmd.com/read/29214368/renal-pharmacists-perceptions-and-current-practices-of-assessing-medication-adherence-in-dialysis-patients
#13
Saurav Ghimire, Colin Banks, Matthew D Jose, Ronald L Castelino, Syed Tabish R Zaidi
Background Medication nonadherence is a major problem in chronic kidney failure patients undergoing dialysis. Pharmacists play a vital role in improving medication-related patient outcomes, reducing drug-related problems, and improving medication adherence. However, little is known about how pharmacists assess medication adherence in dialysis patients. Objective To measure pharmacists' perceptions, current practices, and barriers to assessing adherence in dialysis patients. Setting Australian renal-specialised pharmacists...
December 6, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29213265/lactobacillus-plantarum-mys6-ameliorates-fumonisin-b1-induced-hepatorenal-damage-in-broilers
#14
B V Deepthi, Rakesh Somashekaraiah, K Poornachandra Rao, N Deepa, N K Dharanesha, K S Girish, M Y Sreenivasa
Fumonisin B1 (FB1), a mycotoxin produced by Fusarium species is a predominant Group 2B carcinogen occurring in maize and maize-based poultry feeds. It is shown to be nephrotoxic, hepatotoxic, neurotoxic, and immunosuppressing in animals. In this study, we report the ameliorating effects of a probiotic strain, Lactobacillus plantarum MYS6 on FB1-induced toxicity and oxidative damage in broilers. A 6-week dietary experiment consisting of 48 broilers was performed in six treatment groups. Probiotic treatment (109 cells/mL) involved pre-colonization of broilers with L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29212268/comp-angiopoietin-1-mitigates-changes-in-lipid-droplet-size-macrophage-infiltration-of-adipose-tissue-and-renal-inflammation-in-streptozotocin-induced-diabetic-mice
#15
Yu Jin Jung, Woong Park, Tung Nguyen-Thanh, Kyung Pyo Kang, Heung Young Jin, Suhn Hee Kim, Wonhee Suh, Won Kim
Adipose tissue is considered to be an endocrine organ, and adipocyte size correlates with insulin resistance and metabolic parameters in obesity. There is little data on the effects of angiopoietin-1 in adipose tissue and kidney in streptozotocin (STZ)-induced diabetes. In this study, we investigated the protective effect of COMP-angiopoietin-1 (COMP-Ang1), a potent variant of angiopoietin-1, on vascular endothelial cells in epididymal adipose tissue and its regulatory effect on other metabolic parameters, such as lipid droplet diameter, macrophage infiltration, and renal inflammation in STZ-treated mice...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212248/impact-of-complement-component-3-4-5-single-nucleotide-polymorphisms-on-renal-transplant-recipients-with-antibody-mediated-rejection
#16
Zijie Wang, Haiwei Yang, Miao Guo, Zhijian Han, Jun Tao, Hao Chen, Yuqiu Ge, Ke Wang, Ruoyun Tan, Ji-Fu Wei, Min Gu
Antibody-mediated rejection (ABMR) is an important risk of allograft dysfunction in kidney transplantation. The complement system is considered to be associated with the generation of alloreative antibodies and donor-specific antibodies. However, the association of complement single nucleotide polymorphisms (SNPs) with ABMR still remained unclear. Blood samples of 199 renal transplant recipients containing 68 with ABMR and 131 with stable graft function were collected, and analyzed by next-generation sequencing with an established gene panel...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211750/chow-fed-uc-davis-strain-female-lepr-fatty-zucker-rats-exhibit-mild-glucose-intolerance-hypertriglyceridemia-and-increased-urine-volume-all-reduced-by-a-brown-norway-strain-chromosome-1-congenic-donor-region
#17
Craig H Warden, Ahmed Bettaieb, Esther Min, Janis S Fisler, Fawaz G Haj, Judith S Stern
Our objective is to identify genes that influence the development of any phenotypes of type 2 diabetes (T2D) or kidney disease in obese animals. We use the reproductively isolated UC Davis fatty Zucker strain rat model in which the defective chromosome 4 leptin receptor (LeprfaSte/faSte) results in fatty obesity. We previously produced a congenic strain with the distal half of chromosome 1 from the Brown Norway strain (BN) on a Zucker (ZUC) background (BN.ZUC-D1Rat183-D1Rat90). Previously published studies in males showed that the BN congenic donor region protects from some phenotypes of renal dysfunction and T2D...
2017: PloS One
https://www.readbyqxmd.com/read/29211283/systemic-effect-of-mineral-aggregate-based-cements-histopathological-analysis-in-rats
#18
Lucas da Fonseca Roberti Garcia, Claudia Huck, Fernando Augusto Cintra Magalhães, Pedro Paulo Chaves de Souza, Carlos Alberto de Souza Costa
OBJECTIVE: Several studies reported the local tissue reaction caused by mineral aggregate-based cements. However, few studies have investigated the systemic effects promoted by these cements on liver and kidney when directly applied to connective tissue. The purpose of this in vivo study was to investigate the systemic effect of mineral aggregate-based cements on the livers and kidneys of rats. MATERIAL AND METHODS: Samples of Mineral Trioxide Aggregate (MTA) and a calcium aluminate-based cement (EndoBinder) containing different radiopacifiers were implanted into the dorsum of 40 rats...
November 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29210064/normothermic-machine-perfusion-for-the-assessment-and-transplantation-of-declined-human-kidneys-from-donation-after-circulatory-death-donors
#19
S A Hosgood, E Thompson, T Moore, C H Wilson, M L Nicholson
BACKGROUND: A significant proportion of donation after circulatory death (DCD) kidneys are declined for transplantation because of concerns over their quality. Ex vivo normothermic machine perfusion (NMP) provides a unique opportunity to assess the quality of a kidney and determine its suitability for transplantation. METHODS: In phase 1 of this study, declined human DCD kidneys underwent NMP assessment for 60 min. Kidneys were graded 1-5 using a quality assessment score (QAS) based on macroscopic perfusion, renal blood flow and urine output during NMP...
December 6, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29209891/renal-response-to-anaphylaxis-in-anesthetized-rats-and-isolated-perfused-rat-kidneys-roles-of-nitric-oxide
#20
Kiyotaka Mukai, Yuhichi Kuda, Toshishige Shibamoto, Mamoru Tanida, Yasutaka Kurata, Hitoshi Yokoyama
We determined the renal responses to anaphylaxis and the effects of a nitric oxide synthesis inhibitor, L-NAME, in anesthetized rats and isolated perfused rat kidneys. After the ovalbumin antigen injection, the sensitized rats showed transient and substantial decreases in mean blood pressure and renal blood flow and an increase in renal vascular resistance. Creatinine clearance, a measure of renal function, decreased to 53% baseline at 2 h after antigen. L-NAME pretreatment significantly enhanced the antigen-induced renal vasoconstriction and renal dysfunction...
December 5, 2017: Journal of Physiological Sciences: JPS
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