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https://www.readbyqxmd.com/read/29906428/effects-of-coffee-intake-on-incident-chronic-kidney-disease-community-based-prospective-cohort-study
#1
Jong Hyun Jhee, Ki Heon Nam, Seong Yeong An, Min-Uk Cha, Misol Lee, Seohyun Park, Hyoungnae Kim, Hae-Ryong Yun, Youn Kyung Kee, Jung Tak Park, Tae-Ik Chang, Ea Wha Kang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: Drinking coffee can raise public health problems, but the association between coffee and kidney disease is unknown. We studied whether coffee intake can affect the development of chronic kidney disease in the general population. METHODS: We analyzed 8717 subjects with normal renal function recruited from the KoGES cohort. Based on food frequency questionnaire, coffee consumption was categorized into five groups: 0/week, <1 cup/week, 1-6 cups/week, 1 cup/day, and ≥2 cups/day...
June 12, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29906338/a-nutraceutical-diet-based-on-lespedeza-spp-vaccinium-macrocarpon-and-taraxacum-officinale-improves-spontaneous-feline-chronic-kidney-disease
#2
Alessandro Di Cerbo, Tommaso Iannitti, Gianandrea Guidetti, Sara Centenaro, Sergio Canello, Raffaella Cocco
Chronic kidney disease is characterized by structural and/or functional impairment of one or both kidneys persisting for more than 3 months. In cats, chronic kidney disease can frequently occur in animals aged over 9 years with an incidence of approximately 10%. Thirty-four client-owned, neutered cats, suffering from stage II-III chronic kidney disease and diagnosed according to the International Renal Interest Society guidelines were randomly assigned to receive either a control diet (n = 17) or a nutraceutical diet (ND; n = 17) for 90 days...
June 2018: Physiological Reports
https://www.readbyqxmd.com/read/29905619/pharmacokinetic-comparison-of-two-mycophenolate-mofetil-formulations-in-kidney-transplant-recipients
#3
Jun Zhang, YongGang Luo, ZhenFeng Zhu, GuiWen Feng, Zhi Sun, XiaoJian Zhang
BACKGROUND: The aim of this study was to investigate and compare the pharmacokinetic (PK) characteristics of mycophenolate mofetil (MMF) capsule and MMF dispersible tablet by detecting the active metabolite of mycophenolic acid (MPA) in Chinese kidney transplant recipients. METHODS: In the prospective, randomized, open-label study, the renal transplant patients were given a multiple-dose of either MMF capsule or MMF dispersible tablet combination with tacrolimus (Tac)...
June 12, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29903699/a-putative-role-of-apolipoprotein-l1-polymorphism-in-renal-parenchymal-scarring-following-febrile-urinary-tract-infection-in-nigerian-under-five-children-proposal-for-a-case-control-association-study
#4
Emmanuel Ademola Anigilaje
BACKGROUND: Although urinary tract infection (UTI) resolves with prompt treatment in a majority of children, some children, especially those aged less than 5 years, also develop renal parenchymal scarring (RPS). RPS causes high blood pressure that may lead to severe chronic kidney disease and end-stage renal disease (ESRD). Although the risk of UTI is higher in white children than in black children, it is unknown whether RPS is more common in white children than in black children as data are scarce in this regard...
June 14, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29901634/high-dose-fulvestrant-as-third-line-endocrine-therapy-for-breast-cancer-metastasis-to-the-left-kidney-a-case-report-and-literature-review
#5
Dandan Xia, Huiyu Wang, Runjie Wang, Chaoying Liu, Junying Xu
RATIONALE: Endocrine therapy plays an important role in the treatment of patients with hormone receptor-positive breast cancer. Renal metastasis of breast cancer is rare in clinical practice. PATIENT CONCERNS: We present here a 54-year-old woman with breast cancer after first line chemotherapy and second line endocrinotherapy (i.e., toremifene & exemestane) failure. DIAGNOSES: The patient was rarely diagnosed breast cancer metastasis to the kidney and a positive hormone status (ER and PR) but was negative for human epidermal factor receptor 2 (HER2)...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901607/membranoproliferative-glomerulonephritis-like-findings-for-tafro-syndrome-associated-with-an-anterior-mediastinal-tumor-a-case-report
#6
Yoshitaka Furuto, Hirotsugu Hashimoto, Hajime Horiuti, Yuko Shibuya
RATIONALE: TAFRO syndrome is a systemic inflammatory disease proposed recently from Japan. The cause of TAFRO syndrome is unclear. Moreover, the disease characteristics and kidney pathology are yet unknown well and there are few cases. Herein, we report a patient with TAFRO syndrome and present the features of the renal histopathology. PATIENT CONCERNS: A 55-year-old woman presented to our hospital with the main complaint of subacute dyspnoea. DIAGNOSIS: Physical findings included a low-grade fever and generalised oedema...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901292/-subcapsular-renal-hematomas-after-ureteroscopic-lithotripsy
#7
B G Guliev, B K Komyakov, A Yu Zaikin
INTRODUCTION: Renal hematomas (RH) are a rare complication of retrograde endoscopic lithotripsy (REL). This study aimed to investigate the incidence and causes of RH after REL in patients with ureteral stones of different locations. MATERIALS AND METHODS: From 2001 to 2016, 1214 REL were performed at the Urology Clinic of the Mechnikov NWSMU. The analyzes of patients who had RH after REL included the following parameters: age, gender, history of upper urinary tract (UUT) surgery and concomitant diseases (diabetes mellitus, hypertension), the baseline kidney function, the stone characteristics and the degree of hydronephrosis observed in the postoperative period, results of laboratory tests, ultrasound and spiral computed tomography (SCT) of the kidneys...
May 2018: Urologii︠a︡
https://www.readbyqxmd.com/read/29901130/grape-seed-proanthocyanidins-protect-against-streptozotocin%C3%A2-induced-diabetic-nephropathy-by-attenuating-endoplasmic-reticulum-stress%C3%A2-induced-apoptosis
#8
Zhaoli Gao, Guangyi Liu, Zhao Hu, Weiwei Shi, Binbin Chen, Peimei Zou, Xianhua Li
Diabetic nephropathy (DN) is by far the most common cause of end‑stage renal disease (ESRD) in industrial countries, accounting for ~45% of all new ESRD cases in the United States. Grape seed proanthocyanidin extracts (GSPE) are powerful antioxidants, with an antioxidant ability 50‑fold greater than that of vitamin E and 20‑fold greater than that of vitamin C. The present study investigated whether GSPE can protect against streptozotocin (STZ)‑induced DN and aimed to elucidate a possible mechanism...
June 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900001/transfusion-management-of-incident-dialysis-patients-in-canada-a-prospective-observational-study
#9
Aminu K Bello, Christine M Ribic, Serge H Cournoyer, Mercedeh Kiaii, Martine LeBlanc, Melanie Poulin-Costello, David N Churchill, Norman Muirhead
Background: Several studies have demonstrated harm associated with using erythropoiesis-stimulating agents (ESA) to achieve higher hemoglobin (Hb) levels. Subsequently, more conservative use of ESAs has changed anemia therapy in patients with chronic renal failure. Objective: The objectives were to identify transfusion rates in hemodialysis (HD) patients during the first year of therapy, to identify factors associated with the probability of transfusion, describe reasons for the transfusions, and identify the Hb values associated with each transfusion...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29899374/role-and-prognostic-value-of-individual-ambulatory-blood-pressure-components-in-chronic-kidney-disease
#10
Fabio Angeli, Giorgio Gentile, Monica Trapasso, Paolo Verdecchia, Gianpaolo Reboldi
Hypertension is a key risk factor for chronic kidney disease (CKD), but can also be a detrimental consequence of established CKD. Unsurprisingly, the majority of subjects with abnormal creatinine in the general population are also hypertensive, with a huge toll on national health care systems worldwide due to a staggering increase in the risk of cardiovascular complications and end-stage renal disease requiring renal replacement therapy. In this setting, a comprehensive and careful assessment of the whole 24-h blood pressure (BP) profile could be of paramount importance in ensuring a timely diagnosis of hypertension and an optimal therapeutic control...
June 13, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29898489/-ace-inhibitors-and-arb-in-chronic-kidney-disease-what-has-to-be-considered
#11
Martin Zeier
Proteinuric kidney disease, especially in the early and middle stages of renal insufficiency, may be favorably affected by ACE-I/ARB. The progression of renal insufficiency is thereby slowed down and dialysis obligation occurs later or can even be avoided. This effect is independent of the underlying glomerular kidney disease. In the advanced stage of renal insufficiency, the benefit of ACE-I/ARB cannot yet be conclusively assessed. The interruption of ACE-I/ARB therapy may possibly contribute to a certain recovery of renal function and delay the onset of dialysis a little...
June 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29897289/the-impact-of-cannabidiol-treatment-on-regulatory-t-17-cells-and-neutrophil-polarization-in-acute-kidney-injury
#12
Babak Baban, Md Nasrul Hoda, Aneeq Malik, Hesam Khodadadi, Erika Simmerman, Kumar Vaibhav, Mahmood S Mozaffari
Hallmark features of acute kidney injury (AKI) include mobilization of immune and inflammatory mechanisms culminating in tissue injury. Emerging information indicates heterogeneity of neutrophils with pro- and anti-inflammatory functions (N1 and N2, respectively). Also, regulatory T-17 (Treg17) cells curtail Th-17-mediated pro-inflammatory responses. However, the status of Treg17 cells and neutrophil phenotypes in AKI are not established. Further, cannabidiol exerts immunoregulatory effects but its impact on Treg17 cells and neutrophil subtypes is not established...
June 13, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29897288/intermittent-hypoxia-exacerbates-increased-blood-pressure-in-rats-with-chronic-kidney-disease
#13
Jennifer L Riggs, Carolyn E Pace, Heather H Ward, Laura V Gonzalez Bosc, Lynnette Rios, Adleaeda Barrera, Nancy L Kanagy
Kidney injury and sleep apnea (SA) are independent risk factors for hypertension. Exposing rats to intermittent hypoxia (IH) to simulate SA increases blood pressure while adenine feeding causes persistent kidney damage to model chronic kidney disease (CKD). We hypothesized that exposing CKD rats to IH would exacerbate the development of hypertension and renal failure. Male Sprague-Dawley rats were fed a 0.2% adenine or control diet until blood urea nitrogen (BUN) was &gt; 120 mg/dL in adenine fed rats (14 {plus minus} 4 days)...
June 13, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29896981/astragaloside-iv-ameliorates-early-diabetic-nephropathy-by-inhibition-of-mek1-2-erk1-2-rsk2-signaling-in-streptozotocin-induced-diabetic-mice
#14
Gaofeng Song, Pengxun Han, Huili Sun, Mumin Shao, Xuewen Yu, Wenjing Wang, Dongtao Wang, Wuyong Yi, Na Ge, Shunmin Li, Tiegang Yi
Objective The aim of this study was to investigate the renoprotective effects and molecular mechanisms of astragaloside IV (AS-IV) in streptozotocin (STZ)-induced diabetic mice. Methods Male C57BL/6 mice were injected intraperitoneally with STZ at 200 mg/kg body weight. AS-IV was administered for 8 consecutive weeks, beginning 1 week after STZ injection. Body weight, 24-hour urinary albumin excretion, and fasting blood glucose were measured. Kidney tissues were examined by histopathological analyses. Total levels and phosphorylation of mitogen-activated protein kinase 1/2 (MEK1/2), extracellular signal-regulated kinases 1 and 2 (ERK1/2), and ribosomal S6 kinase 2 (RSK2) were determined by Western blotting analysis...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29896798/renal-effects-of-norepinephrine-induced-variations-in-mean-arterial-pressure-after-liver-transplantation-a-randomized-cross-over-trial
#15
J Skytte Larsson, G Bragadottir, B Redfors, S-E Ricksten
BACKGROUND: Acute kidney injury is commonly seen after liver transplantation. The optimal perioperative target mean arterial pressure (MAP) for renal filtration, perfusion and oxygenation in liver recipients is not known. The effects of norepinephrine-induced changes in MAP on renal blood flow (RBF), oxygen delivery (RDO2 ), glomerular filtration rate (GFR) and renal oxygenation (=renal oxygen extraction, RO2 Ex) were therefore studied early after liver transplantation. METHODS: Ten patients with an intra- and post-operative vasopressor-dependent systemic vasodilation were studied early after liver transplantation during sedation and mechanical ventilation...
June 12, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29896409/urinary-neutrophil-gelatinase-associated-lipocalin-is-excellent-predictor-of-acute-kidney-injury-in-septic-elderly-patients
#16
Erica Pires da Rocha, Lais Gabriela Yokota, Beatriz Motta Sampaio, Karina Zanchetta Cardoso Eid, Dayana Bitencourt Dias, Fernanda Moreira de Freitas, Andre Luis Balbi, Daniela Ponce
Elderly is the main age group affected by acute kidney injury (AKI). There are no studies that investigated the predictive properties of urinary (u) NGAL as an AKI marker in septic elderly population. This study aimed to evaluate the efficacy of uNGAL as predictor of AKI diagnosis and prognosis in elderly septic patients admitted to ICUs. We prospectively studied elderly patients with sepsis admitted to ICUs from October 2014 to November 2015. Assessment of renal function was performed daily by serum creatinine and urine output...
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29895474/microfilaria-in-kidney-biopsy-a-report-of-two-cases
#17
Swasti Shubham, Arvind Ahuja, Minakshi Bhardwaj
Filariasis is traditionally diagnosed on finding microfilaria in peripheral blood smear and in cases of occult filariasis by immunological tests. Clinically, it presents with a wide range of symptoms and signs. We present two cases of filariasis presenting with renal symptoms warranting kidney biopsy. Histopathology of both revealed microfilaria in the glomerular capillary loop. First case was a 23-year-old male who presented with complaints of passage of milky urine. Second case was a 36-year-old female patient who presented with complaints of gross hematuria...
June 9, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29895432/targeted-inhibition-of-axl-receptor-tyrosine-kinase-ameliorates-anti-gbm-induced-lupus-like-nephritis
#18
Yuxuan Zhen, Iris J Lee, Fred D Finkelman, Wen-Hai Shao
Glomerulonephritis (GN) is a typical lesion in autoantibody and immune complex disorders, including SLE. Because the Gas6/Axl pathway has been implicated in the pathogenesis of many types of GN, targeting this pathway might ameliorate GN. Consequently, we have studied the efficacy and mechanism of R428, a potent selective Axl inhibitor, in the prevention of experimental anti-GBM nephritis. Axl upregulation was investigated with Sp1/3 siRNA in the SV40-transformed mesangial cells. For Axl inhibition, a daily dose of R428 (125 mg/kg) or vehicle was administered orally...
June 9, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29895030/national-trends-in-emergency-room-visits-of-dialysis-patients-for-adverse-drug-reactions
#19
Lili Chan, Aparna Saha, Priti Poojary, Kinsuk Chauhan, Nidhi Naik, Steven Coca, Pranav S Garimella, Girish N Nadkarni
BACKGROUND: Various medications are cleared by the kidneys, therefore patients with impaired renal function, especially dialysis patients are at risk for adverse drug events (ADEs). There are limited studies on ADEs in maintenance dialysis patients. METHODS: We utilized a nationally representative database, the Nationwide Emergency Department Sample, from 2008 to 2013, to compare emergency department (ED) visits for dialysis and propensity matched non-dialysis patients...
June 12, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29895022/diagnosis-and-treatment-of-metabolic-acidosis-in-patients-with-chronic-kidney-disease-position-statement-of-the-working-group-of-the-polish-society-of-nephrology
#20
Marcin Adamczak, Anna Masajtis-Zagajewska, Oktawia Mazanowska, Katarzyna Madziarska, Tomasz Stompór, Andrzej Więcek
Metabolic acidosis is commonly found in patients with chronic kidney disease (CKD), and its causes are: impaired ammonia excretion, reduced tubular bicarbonate reabsorption and insufficient renal bicarbonate production in relation to the amount of acids synthesised by the body and ingested with food. As the consequence, numerous metabolic abnormalities develop, which may lead to dysfunction of several organs. In observational studies, it has been found that CKD patients with metabolic acidosis are characterised by faster progression of kidney disease towards end stage kidney failure, and by increased mortality...
June 7, 2018: Kidney & Blood Pressure Research
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