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JOURNAL ARTICLE
Meng Zhang, Xue Zhuang, Siqi Li, Yansong Wang, Xiangyu Zhang, Jinlian Li, Dongmei Wu
Binary ethosome vesicles have been developed as flexible lipid vesicles for the enhanced physicochemical stability and skin delivery of drugs. This work aimed to prepare phloretin-loaded propylene glycol ethosomes (PHL-PGEs) to improve their stability, skin permeability and antioxidant activity. PHL-PGEs were prepared via the ethanol injection method and optimized using different weight ratios of ethanol to propylene glycol (PG). When the ethanol/PG mass ratio changed from 10:0 to 0:10, the encapsulation efficiency and stability of ethosomes increased...
December 21, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#22
JOURNAL ARTICLE
Qiuying Wang, Jing Wei, Bin Wan, Qiong An, Jie Gao, Guoqiang Zhuang
Preventing soil nitrogen (N) losses driven by microbial nitrification and denitrification contributes to improving global environmental concerns caused by NO3 - -N leaching and N2 O emission. Quorum sensing (QS) signals regulate nitrification and denitrification of N-cycling bacteria in pure culture and water treatment systems, and mediate the composition of ammonia-oxidizing archaea (AOA) and ammonia-oxidizing bacteria (AOB) in activated sludge. However, whether disrupting QS could prevent soil N losses remains unclear...
January 6, 2024: Environmental Research
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JOURNAL ARTICLE
Haofan Duan, Yu You, Gang Wang, Xiangze Ou, Jin Wen, Qiao Huang, Pengbo Lyu, Yaru Liang, Qingyu Li, Jianyu Huang, Yun-Xiao Wang, Hua-Kun Liu, Shi Xue Dou, Wei-Hong Lai
The concentration difference in the near-surface region of lithium metal is the main cause of lithium dendrite growth. Resolving this issue will be key to achieving high-performance lithium metal batteries (LMBs). Herein, we construct a lithium nitrate (LiNO3 )-implanted electroactive β phase polyvinylidene fluoride-co-hexafluoropropylene (PVDF-HFP) crystalline polymorph layer (PHL). The electronegatively charged polymer chains attain lithium ions on the surface to form lithium-ion charged channels. These channels act as reservoirs to sustainably release Li ions to recompense the ionic flux of electrolytes, decreasing the growth of lithium dendrites...
January 8, 2024: Nano-Micro Letters
#24
JOURNAL ARTICLE
Tarek Al-Sanouri, Yousef Khader, Ekhlas Hailat, Sereen Iweir, Mohammad Abu Khudair, Mohannad Al Nsour
INTRODUCTION: Brucellosis is prevalent in Mediterranean countries. The aim of this study was to determine the seroprevalence of brucellosis and associated factors among Syrian refugees in Jordan. METHODS: A cross-sectional study was conducted among adult Syrian refugees who attended the Public Health Lab (PHL) in Al Mafraq governorate, during the period of May-June 2022 to obtain a health certificate, which is legally required to receive governmental authorization for employment in Jordan...
2023: Journal of Pathogens
#25
JOURNAL ARTICLE
Donna L Bedard, Greta Van Slyke, Ulrich Nübel, Mary M Bateson, Sue Brumfield, Yong Jun An, Eric D Becraft, Jason M Wood, Vera Thiel, David M Ward
Three strains of thermophilic green sulfur bacteria (GSB) are known; all are from microbial mats in hot springs in Rotorua, New Zealand (NZ) and belong to the species Chlorobaculum tepidum . Here, we describe diverse populations of GSB inhabiting Travel Lodge Spring (TLS) (NZ) and hot springs ranging from 36.1 °C to 51.1 °C in the Republic of the Philippines (PHL) and Yellowstone National Park (YNP), Wyoming, USA. Using targeted amplification and restriction fragment length polymorphism analysis, GSB 16S rRNA sequences were detected in mats in TLS, one PHL site, and three regions of YNP...
December 4, 2023: Microorganisms
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REVIEW
Janine Fröhlich-Nowoisky, Nadine Bothen, Anna T Backes, Michael G Weller, Ulrich Pöschl
Protein modifications such as oligomerization and tyrosine nitration alter the immune response to allergens and may contribute to the increasing prevalence of allergic diseases. In this mini-review, we summarize and discuss relevant findings for the major birch and grass pollen allergens Bet v 1 and Phl p 5 modified with tetranitromethane (laboratory studies), peroxynitrite (physiological processes), and ozone and nitrogen dioxide (environmental conditions). We focus on tyrosine nitration and the formation of protein dimers and higher oligomers via dityrosine cross-linking and the immunological effects studied...
2023: Front Allergy
#27
JOURNAL ARTICLE
C Pötzsch, Lars Kurch, S Naumann, T W Georgi, O Sabri, D Stoevesandt, M Cepelova, D Körholz, C Mauz-Körholz, D Hasenclever, R Kluge
Activated brown fat (aBAT) is known to affect the evaluation of 18 F-FDG PET scans, especially in young patients. The aim of this study was to determine factors influencing the occurrence of aBAT, and to investigate the effectiveness of the two preventive measures, warming and beta-blocker (propranolol) administration. Five-hundred-twenty-eight 18 F-FDG-PET scans of 241 EuroNet-PHL-C2 trial patients from 41 nuclear medicine departments in Germany and Czech Republic were screened for aBAT. The occurrence of aBAT was analyzed with patient characteristics (age, sex, body mass index, predisposition to aBAT), weather data at the day of 18 F-FDG PET scanning as well as the preventive measures taken...
December 11, 2023: Scientific Reports
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JOURNAL ARTICLE
Lisa Prickler, Ulrike Baranyi, Konstantinos Mengrelis, Anna Marianne Weijler, Verena Kainz, Bernhard Kratzer, Romy Steiner, Jasmin Mucha, Elisa Rudoph, Nina Pilat, Barbara Bohle, Herbert Strobl, Winfried Franz Pickl, Rudolf Valenta, Birgit Linhart, Thomas Wekerle
INTRODUCTION: Prophylactic strategies to prevent the development of allergies by establishing tolerance remain an unmet medical need. We previously reported that the transfer of autologous hematopoietic stem cells (HSC) expressing the major timothy grass pollen allergen, Phl p 5, on their cell surface induced allergen-specific tolerance in mice. In this study, we investigated the ability of allergen-expressing immune cells (dendritic cells, CD4+ T cells, CD8+ T cells, and CD19+ B cells) to induce allergen-specific tolerance in naive mice and identified CD19+ B cells as promising candidates for allergen-specific cell therapy...
2023: Frontiers in Immunology
#29
RANDOMIZED CONTROLLED TRIAL
Tiziano Barbui, Alessandra Carobbio, Valerio De Stefano, Alberto Alvarez-Larran, Arianna Ghirardi, Greta Carioli, Francesca Fenili, Elena Rossi, Fabio Ciceri, Massimiliano Bonifacio, Alessandra Iurlo, Francesca Palandri, Giulia Benevolo, Fabrizio Pane, Alessandra Ricco, Giuseppe Carli, Marianna Caramella, Davide Rapezzi, Caterina Musolino, Sergio Siragusa, Elisa Rumi, Andrea Patriarca, Nicola Cascavilla, Barbara Mora, Emma Cacciola, Laura Calabresi, Giuseppe Gaetano Loscocco, Paola Guglielmelli, Francesca Gesullo, Silvia Betti, Francesco Ramundo, Francesca Lunghi, Luigi Scaffidi, Cristina Bucelli, Daniele Cattaneo, Nicola Vianelli, Marta Bellini, Maria Chiara Finazzi, Gianni Tognoni, Alessandro Rambaldi, Alessandro Maria Vannucchi
In patients with low-risk polycythemia vera, exposure to low-dose Ropeginterferon alfa-2b (Ropeg) 100 µg every 2 weeks for 2 years was more effective than the standard treatment of therapeutic phlebotomy in maintaining target hematocrit (HCT) (< 45%) with a reduction in the need for phlebotomy without disease progression. In the present paper, we analyzed drug survival, defined as a surrogate measure of the efficacy, safety, adherence, and tolerability of Ropeg in patients followed up to 5 years...
February 2024: Annals of Hematology
#30
REVIEW
Aditya K Gupta, Tong Wang, Mary A Bamimore, Shruthi Polla Ravi, Mesbah Talukder
BACKGROUND: Combination treatments may improve the utility of approved agents for the treatment of pattern hair loss (PHL); however, head-to-head comparisons are lacking. OBJECTIVE: The aim of the study was to compare the efficacy of 5% minoxidil, platelet-rich plasma (PRP), and microneedling across adults with PHL insofar as change in total hair density at 24 weeks. METHODS: We conducted a literature search in July 2022. Through our Bayesian network meta-analysis, we estimated treatments' surface under the cumulative ranking distribution (SUCRA) values and relative effects - in terms of mean difference (MD)...
December 2023: Skin Appendage Disorders
#31
JOURNAL ARTICLE
Yuling Zhang, Xizhen Cheng, Yanan Wang, Haochuan Guo, Yongxing Song, Hongfang Wang, Donglai Ma
The specific role of phlorizin (PHL), which has antioxidant, anti-inflammatory, hypoglycemic, antiarrhythmic and antiaging effects, on myocardial fibrosis (MF) and the related pharmacological mechanisms remain unknown. The objective of this study was to determine the protective actions of PHL on isoprenaline (ISO)-induced MF and its molecular mechanisms in mice. PHL was administered at 100 and 200 mg/kg for 15 consecutive days with a subcutaneous injection of ISO (10 mg/kg). MF was induced by ISO and alleviated by treatment with PHL, as shown by reduced fibrin accumulation in the myocardial interstitium and decreased levels of myocardial enzymes, such as creatinine kinase-MB, lactate dehydrogenase, and aspartate transaminase...
November 2023: Heliyon
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JOURNAL ARTICLE
Cristian Galaz Torres, Arianna Ricci, Giuseppina Paola Parpinello, Angelita Gambuti, Alessandra Rinaldi, Luigi Moio, Luca Rolle, Maria Alessandra Paissoni, Fulvio Mattivi, Daniele Perenzoni, Panagiotis Arapitsas, Matteo Marangon, Christine Mayr Marangon, Davide Slaghenaufi, Maurizio Ugliano, Andrea Versari
Astringency is an essential sensory attribute of red wine closely related to the saliva precipitation upon contact with the wine. In this study a data matrix of 52 physico-chemical parameters was used to predict the Saliva Precipitation Index (SPI) in 110 Italian mono-varietal red wines using partial least squares regression (PLSr) with variable selection by Variable Importance for Projection (VIP) and the significance of regression coefficients. The final PLSr model, evaluated using a test data set, had 3 components and yielded an R2 test of 0...
2023: Current research in food science
#33
JOURNAL ARTICLE
Luke W Meredith, Mustafa Aboualy, Rachel Ochola, Mehmet Ozel, Abdinasir Abubakar, Amal Barakat
INTRODUCTION: The COVID-19 pandemic placed unprecedented stress on laboratories in the Eastern Mediterranean Region. Building on existing capacity for influenza diagnostics, countries introduced COVID-19 diagnostic support to ~100% regional coverage. A key challenge during the expansion was maintaining quality testing in laboratories, ensuring that correct results were shared with medical facilities. METHODS: WHO organized two rounds of independently monitored severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) external quality assurance programs (EQAP)...
November 2023: Influenza and Other Respiratory Viruses
#34
JOURNAL ARTICLE
Elaine Fuertes, Debbie Jarvis, Holly Lam, Bethan Davies, Daniela Fecht, Joana Candeias, Carsten B Schmidt-Weber, Abdel Douiri, Anna Slovick, Enrico Scala, Thomas El Smith, Mohamed Shamji, Jeroen Tm Buters, Lorenzo Cecchi, Stephen J Till
BACKGROUND: Studies have linked daily pollen counts to respiratory allergic health outcomes but few have considered allergen levels. OBJECTIVE: This study assessed associations of grass pollen counts and allergen levels (Phl p 5) with 1) respiratory allergic health symptoms in a panel of 93 adults with moderate-severe allergic rhinitis and 2) daily asthma hospital admissions in London, UK. METHODS: Daily symptom and medication scores were collected from adult participants in an allergy clinical trial...
November 21, 2023: Journal of Allergy and Clinical Immunology
#35
JOURNAL ARTICLE
Elsa Erixon
OBJECTIVES: This study estimated the permanent hearing loss (PHL) prevalence among newborns and 6-year-olds in the Uppsala region (Sweden), compared how different definitions affected this estimation, and evaluated the outcome of the three hearing screening occasions for children. METHODS: A retrospective investigation of medical records and audiograms was conducted for children born in 2011-2012. Data extraction was performed when the children had reached 7 years of age...
November 11, 2023: International Journal of Pediatric Otorhinolaryngology
#36
JOURNAL ARTICLE
Dzhemal Moten, Tsvetelina Batsalova, Desislava Apostolova, Tsvetelina Mladenova, Balik Dzhambazov, Ivanka Teneva
Allergic diseases are a global public health problem that affects up to 30% of the population in industrialized societies. More than 40% of allergic patients suffer from grass pollen allergy. Grass pollen allergens of group 1 and group 5 are the major allergens, since they induce allergic reactions in patients at high rates. In this study, we used immunoinformatic approaches to design an effective epitope-based vaccine against the grass group 1 allergens. After the alignment of all known pollen T-cell and B-cell epitopes from pollen allergens available in the public databases, the epitope GTKSEVEDVIPEGWKADTSY was identified as the most suitable for further analyses...
November 8, 2023: Advances in Respiratory Medicine
#37
JOURNAL ARTICLE
Susan K Vester, Anna M Davies, Rebecca L Beavil, Balraj S Sandhar, Andrew J Beavil, Hannah J Gould, Brian J Sutton, James M McDonnell
We have previously produced a toolkit of antibodies, comprising recombinant human antibodies of all but one of the human isotypes, directed against the polcalcin family antigen Phl p 7. In this work, we complete the toolkit of human antibody isotypes with the IgD version of the anti-Phl p 7 monoclonal antibody. We also raised a set of nanobodies against the IgD anti-Phl p 7 antibody and identify and characterize one paratope-specific nanobody. This nanobody also binds to the IgE isotype of this antibody, which shares the same idiotype, and orthosterically inhibits the interaction with Phl p 7...
November 16, 2023: Antibodies
#38
JOURNAL ARTICLE
Nariman Ammar, Olufunto A Olusanya, Chad Melton, Lokesh Chinthala, Xiaolei Huang, Brianna M White, Arash Shaban-Nejad
BACKGROUND: Health promotion can empower populations to gain more control over their well-being by using digital interventions that focus on preventing the root causes of diseases. Digital platforms for personalized health coaching can improve health literacy and information-seeking behavior, leading to better health outcomes. Personal health records have been designed to enhance patients' self-management of a disease or condition. Existing personal health records have been mostly designed and deployed as a supplementary service that acts as views into electronic health records...
November 15, 2023: JMIR Formative Research
#39
JOURNAL ARTICLE
Ana Kormos, George Dimopoulos, Ethan Bier, Gregory C Lanzaro, John M Marshall, Anthony A James
The field-testing and eventual adoption of genetically-engineered mosquitoes (GEMs) to control vector-borne pathogen transmission will require them meeting safety criteria specified by regulatory authorities in regions where the technology is being considered for use and other locales that might be impacted. Preliminary risk considerations by researchers and developers may be useful for planning the baseline data collection and field research used to address the anticipated safety concerns. Part of this process is to identify potential hazards (defined as the inherent ability of an entity to cause harm) and their harms, and then chart the pathways to harm and evaluate their probability as part of a risk assessment...
2023: Frontiers in Bioengineering and Biotechnology
#40
Tim M Gemeinhardt, Roshan M Regy, Andrea J Mendiola, Heather J Ledterman, Amy Henrickson, Tien M Phan, Young C Kim, Borries Demeler, Chongwoo A Kim, Jeetain Mittal, Nicole J Francis
UNLABELLED: The Polycomb Group (PcG) complex PRC1 represses transcription, forms condensates in cells, and modifies chromatin architecture. These processes are connected through the essential, polymerizing Sterile Alpha Motif (SAM) present in the PRC1 subunit Polyhomeotic (Ph). In vitro , Ph SAM drives formation of short oligomers and phase separation with DNA or chromatin in the context of a Ph truncation ("mini-Ph"). Oligomer length is controlled by the long disordered linker (L) that connects the SAM to the rest of Ph--replacing Drosophila PhL with the evolutionarily diverged human PHC3L strongly increases oligomerization...
October 27, 2023: bioRxiv
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