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M A López-Matas, R Moya, V Cardona, A Valero, P Gaig, A Malet, M Viñas, A García-Moral, M Labrador, E Alcoceba, M Ibero, J Carnés
BACKGROUND AND OBJECTIVES: The homologous group of sweet grasses belongs to the Pooideae subfamily, but grass pollen species from other subfamilies can also cause allergy, such as Cynodon dactylon (Chloridoideae) and Phragmites communis (Arundinoideae). C dactylon and P communis have not been included in the sweet grasses homologous group because of their low cross-reactivity with other grasses. The aims of this study were to investigate the profile of sensitization to C dactylon and P communis in patients sensitized to grasses and to analyze cross-reactivity between these 2 species and temperate grasses...
October 2016: Journal of Investigational Allergology & Clinical Immunology
Teresa Stemeseder, Eva Klinglmayr, Stephanie Moser, Lisa Lueftenegger, Roland Lang, Martin Himly, Gertie J Oostingh, Joerg Zumbach, Arne C Bathke, Thomas Hawranek, Gabriele Gadermaier
BACKGROUND: Allergen specific IgE antibodies are a hallmark of type I allergy. The aim of this cross-sectional study was to analyze the sensitization profiles of an Austrian adolescent population utilizing molecule-based IgE diagnosis. METHODS: Serum samples of 501 non-selected pupils from Salzburg, Austria, were tested in ImmunoCAP ISAC(®) for IgE reactivity to 112 single allergens. Sensitization profiles were assessed and statistically coordinated with reported allergies...
October 18, 2016: Allergy
Gamze Ugurluer, Robert C Miller, Yexiong Li, Juliette Thariat, Pirus Ghadjar, Ulrike Schick, Mahmut Ozsahin
Primary hepatic lymphoma (PHL) is a rare malignancy. We aimed to assess the clinical profile, outcome and prognostic factors in PHL through the Rare Cancer Network (RCN). A retrospective analysis of 41 patients was performed. Median age was 62 years (range, 23-86 years) with a male-to-female ratio of 1.9:1.0. Abdominal pain or discomfort was the most common presenting symptom. Regarding B-symptoms, 19.5% of patients had fever, 17.1% weight loss, and 9.8% night sweats. The most common radiological presentation was multiple lesions...
September 5, 2016: Rare Tumors
Kay L Escuyer, Christine L Waters, Donna L Gowie, Angie M Maxted, Gregory M Farrell, Meghan E Fuschino, Kirsten St George
BACKGROUND: Following the 2013 USA release of the Influenza Virologic Surveillance Right Size Roadmap, the New York State Department of Health (NYSDOH) embarked on an evaluation of data sources for influenza virologic surveillance. OBJECTIVE: To assess NYS data sources, additional to data generated by the state public health laboratory (PHL), which could enhance influenza surveillance at the state and national level. METHODS: Potential sources of laboratory test data for influenza were analyzed for quantity and quality...
October 8, 2016: Influenza and Other Respiratory Viruses
Alessandra Ghiani, Maurizio Bruschi, Sandra Citterio, Ezio Bolzacchini, Luca Ferrero, Giorgia Sangiorgi, Riccardo Asero, Maria Grazia Perrone
Pollen aeroallergens are present in atmospheric particulate matter (PM) where they can be found in coarse biological particles such as pollen grains (aerodynamic diameter dae>10μm), as well as fragments in the finest respirable particles (PM2.5; dae<2.5μm). Nitration of tyrosine residues in pollen allergenic proteins can occur in polluted air, and inhalation and deposition of these nitrated proteins in the human respiratory tract may lead to adverse health effects by enhancing the allergic response in population...
September 14, 2016: Science of the Total Environment
Wenting Luo, Huimin Huang, Peiyan Zheng, Nili Wei, Jiaying Luo, Baoqing Sun, Guangqiao Zeng
There is so far a paucity of data about allergen component-resolved diagnosis, and the prevalence of grass pollen allergen components in China, in contrast to those from western countries. Even in this country, allergies to grass pollen allergen components in the vast south are inadequately described. This study aimed to determine the major sensitizing grass pollens in Guangzhou, the largest city in Guangdong province of southern China. Included in this study were 258 patients having allergic rhinitis with or without asthma and 88 healthy controls...
October 2016: Molecular Immunology
Ana Luiza Chaves Maia, Christian Fernandes, Cynthia Nara Pereira de Oliveira, Claudia Salviano Teixeira, Mariana Silva Oliveira, Daniel Cristian Soares, Gilson Andrade Ramaldes
The aim of this study was develop, characterize and assess the cytotoxic activity of pH-sensitive (pHL-Gd), stealth pH-sensitive (SpHL-Gd), and conventional (convL-Gd) liposomes containing gadodiamide (Gd-DTPA-BMA). Formulations were prepared by reverse-phase evaporation method and their physicochemical properties were evaluated by means of particle size, zeta potential, and Gd-DTPA- BMA entrapment. SpHL-Gd was considered the most promising liposome, since it combines stealth and fusogenic characteristics that can contribute for higher therapeutic efficiency...
September 6, 2016: Current Drug Delivery
Florian Wölbing, Julia Kunz, Wolfgang Eberhard Kempf, Cornelia Grimmel, Jörg Fischer, Tilo Biedermann
BACKGROUND: Overlapping seasons and cross reactivity, especially to grass pollen profilin, can hamper the diagnosis of birch pollen allergy. To identify the primary sensitizing allergen and the clinical relevance of cross sensitization, we correlated sensitization profiles with in vitro and in vivo tests, symptom scores and pollen counts. METHODS: 433 patients with positive skin prick test (SPT) to birch pollen were analyzed regarding IgE to major birch and grass pollen allergens Bet v 1 and Phl p 1/p 5 and the profilins Bet v 2 and Phl p 12...
September 2, 2016: Allergy
Shin Nishio, Ryo Kitagawa, Taro Shibata, Hiroyuki Yoshikawa, Ikuo Konishi, Kimio Ushijima, Toshiharu Kamura
PURPOSE: The Japan Clinical Oncology Group (JCOG) trial JCOG0505 demonstrated the statistically significant non-inferiority of paclitaxel plus carboplatin (TC) to paclitaxel plus cisplatin (TP) in terms of overall survival (OS) in metastatic or recurrent cervical cancer. In that trial, patients were randomly assigned, adjusting for institution and known prognostic factors. The objective of this ancillary study was to evaluate the appropriateness of the adjustment factors used to have randomly assigned treatments and to investigate new potentially useful prognostic factors of paclitaxel plus platinum for future randomized trials in metastatic or recurrent cervical cancer...
October 2016: Cancer Chemotherapy and Pharmacology
Barbara Klein, Heike Mrowetz, Josef Thalhamer, Sandra Scheiblhofer, Richard Weiss, Ludwig Aigner
Allergies and their characteristic TH2-polarized inflammatory reactions affect a substantial part of the population. Since there is increasing evidence that the immune system modulates plasticity and function of the central nervous system (CNS), we investigated the effects of allergic lung inflammation on the hippocampus-a region of cellular plasticity in the adult brain. The focus of the present study was on microglia, the resident immune cells of the CNS, and on hippocampal neurogenesis, i.e., the generation of new neurons...
2016: Frontiers in Cellular Neuroscience
Pedram Fatehi, Weijiue Gao, Yonghui Sun, Mehdi Dashtban
Acidification has been commercialized for producing kraft lignin from black liquor of kraft pulping process. This work intended to evaluate the effectiveness of acidification in extracting lignocelluloses from the spent liquor of neutral sulfite semichemical pulping (NSSC) process and from prehydrolysis liquor (PHL) of kraft-based dissolving pulp production process. The results showed that the NSSC and PHL spent liquors had some lignin-carbohydrate complexes (LCC), and that the square weighted counts of particles with a chord length of 50-150μm in the spent liquors were significantly increased as pH dropped to 1...
October 2016: Bioresource Technology
Mitchell A Yakrus, Jeffrey Driscoll, Allison McAlister, David Sikes, Denise Hartline, Beverly Metchock, Angela M Starks
Ethambutol (EMB) is used as a part of drug regimens for treatment of tuberculosis (TB). Susceptibility of Mycobacterium tuberculosis complex (MTBC) isolates to EMB can be discerned by DNA sequencing to detect mutations in the embB gene associated with resistance. US Public Health Laboratories (PHL) primarily use growth-based drug susceptibility test (DST) methods to determine EMB resistance. The Centers for Disease Control and Prevention (CDC) provides a service for molecular detection of drug resistance (MDDR) by DNA sequencing and concurrent growth-based DST using agar proportion...
2016: Tuberculosis Research and Treatment
M A López-Matas, R Moya, V Cardona, A Valero, P Gaig, A Malet, M Viñas, A García-Moral, M Labrador, E Alcoceba, M Ibero, J Carnés
BACKGROUND: Besides the Pooideae sub-family of grasses, there are other sub-families with allergenic members such as Cynodon dactylon (Chloridoideae) or Phragmites communis (Arundinoideae). Pooideae species belong to the same homologous group (sweet grasses). C. dactylon and P. communis are not included in this group because cross-reactivity with other grasses is not significant. OBJECTIVES: The objectives were to investigate the sensitization profile to C. dactylon and P...
April 11, 2016: Journal of Investigational Allergology & Clinical Immunology
N E Belyaeva, A A Bulychev, G Yu Riznichenko, A B Rubin
A new Thylakoid model is presented, which describes in detail the electron/proton transfer reactions between membrane protein complexes including photosystems II and I (PSII, PSI), cytochrome (Cyt) b 6 f, mobile plastoquinone PQ pool in the thylakoid membrane, plastocyanin in lumen and ferredoxin in stroma, reduction of NADP via FNR and cyclic electron transfer. The Thylakoid model parameters were fitted both to Chl fluorescence induction data (FI) and oxido-reductions of P700 (ΔA 810) measured from 20 μs up to 20 s in pea leaves...
July 1, 2016: Photosynthesis Research
Nieves Segura, Teresa Abos, José A Compaired, Esther Compés, Isabel Guallar, Manuel Morales, Susana Monzón, José Mozota, Pilar Muñoz, Jesús Pola, Macarena Quintana, Beatriz Rojas, Sara San Juan, Felicitas Villa, Cristina Zapata, Lucía Jimeno, Fernando de la Torre
BACKGROUND: Profilin sensitisation is considered a diagnostic confounding factor in areas where patients are exposed to multiple pollens. The aim of this study is to assess pollen sensitisation profiles in adults and children and to evaluate, by means of component-resolved diagnosis (CRD) and skin prick testing (SPT), which pollens may be considered as risk factors of profilin sensitisation in order to establish the best diagnostic approach in polysensitised patients. METHODS: A total of 231 pollen-allergic patients (adults and children) were included, out of the pollen season, from an area with similar levels of pollen exposure...
2016: Clinical and Translational Allergy
Ulrike Baranyi, Andreas M Farkas, Karin Hock, Benedikt Mahr, Birgit Linhart, Martina Gattringer, Margit Focke-Tejkl, Arnd Petersen, Fritz Wrba, Thomas Rülicke, Rudolf Valenta, Thomas Wekerle
BACKGROUND: Therapeutic strategies for the prophylaxis of IgE-mediated allergy remain an unmet medical need. Cell therapy is an emerging approach with high potential for preventing and treating immunological diseases. We aimed to develop a cell-based therapy inducing permanent allergen-specific immunological tolerance for preventing IgE-mediated allergy. METHODS: Wild-type mice were treated with allergen-expressing bone marrow cells under a short course of tolerogenic immunosuppression (mTOR inhibition and costimulation blockade)...
May 2016: EBioMedicine
Aleksandar Cvetkovski, Valerio Bertolasi, Valeria Ferretti
The active pharmaceutical ingredient phloroglucinol (PHL) has been taken as an illustrative molecule to explore the intermolecular interactions which can be established with other molecular entities to build PHL pharmaceutical co-crystals. The crystal structures of five newly synthesized co-crystals are reported, where PHL is crystallized with N-heterocycles, namely 2-hydroxy-6-methylpyridine (1), 2,4-dimethyl-6-hydroxypyrimidine (2), 4-phenylpyridine (3), 2-hydroxypyridine (4) and 2,3,5,6-tetramethylpyrazine (5)...
June 1, 2016: Acta Crystallographica Section B, Structural Science, Crystal Engineering and Materials
Riccardo Asero, Gianni Mistrello, Stefano Amato
BACKGROUND: Up to 50% of patients with pollen allergy are sensitized to at least 1 of the 2 pollen pan-allergens profilin and polcalcin. These allergens could have clinical relevance but the content of profilin and polcalcin in commercial extracts for allergen immunotherapy (AIT) is unknown. OBJECTIVE: To detect these pan-allergens in commercial pollen extracts for AIT from various sources. METHODS: Immunoglobulin E (IgE) reactivity to Phl p 7 and Bet v 2 of sera from 18 adults hypersensitive to profilin and/or polcalcin was investigated by enzyme-linked immunosorbent assay before and after absorption with grass, birch, ragweed, pellitory, and olive pollen extracts for AIT from different producers...
August 2016: Annals of Allergy, Asthma & Immunology
Muazzam Nasrullah, Laura G Wesolowski, Steven F Ethridge, Kevin Cranston, Michael Pentella, Robert A Myers, James T Rudrik, Angela B Hutchinson, Spencer B Bennett, Barbara G Werner
OBJECTIVE: In three U.S. State Public Health Laboratories (PHLs) using a fourth-generation immunoassay (IA), an HIV-1/HIV-2 differentiation antibody IA and a nucleic acid test (NAT), we characterized the yield and time to reporting of acute infections, and cost per positive specimen. METHODS: Routine HIV testing data were collected from July 1, 2012-June 30, 2013 for Massachusetts and Maryland PHLs, and from November 27, 2012-June 30, 2013 for Michigan PHL. Massachusetts and Michigan used fourth-generation and differentiation IAs with NAT conducted by a referral laboratory...
August 2016: Journal of Infection
Yali Xie, Zhengqiang Liu, Guoyong Zhang, Xiangtao Mo, Xuezhi Ding, Liqiu Xia, Shengbiao Hu
Ribosome engineering has proven to be a practical method for increasing antibiotic production, and is extensively applied to strain improvement in antibiotic production and activation of silent genes in several prokaryotes. In this study, ribosome engineering was used to improve production of bioactive secondary metabolites produced by Pseudomonas protegens Pf-5. Rifampicin-resistant mutants that bear the H531N in the β-subunit of RNA polymerase showed improved antifungal activity and morphological changes...
October 2016: Research in Microbiology
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