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https://www.readbyqxmd.com/read/28439304/is-percutaneous-medial-hamstring-myofascial-lengthening-as-anatomically-effective-and-safe-as-the-open-procedure
#1
T Mansour, J Derienne, M Daher, D Sarraf, Y Zoghbi, I Ghanem
BACKGROUND: Medial hamstring fractional lengthening is commonly performed in children with cerebral palsy (CP) to decrease contracture and/or to improve gait. Percutaneous procedures are gaining more and more popularity, even in the paediatric population, with equivocal results. The purpose of this paper was to determine the efficacy and safety of percutaneous medial hamstring myofascial lengthening (PHL). METHODS: This is a prospective randomised controlled trial including 31 knees from 18 consecutive patients with CP scheduled for medial hamstring lengthening in the setting of multilevel tendon lengthening procedures in a university hospital...
2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28410874/predictivity-of-clinical-efficacy-of-sublingual-immunotherapy-slit-based-on-sensitisation-pattern-to-molecular-allergens-in-children-with-allergic-rhinoconjunctivitis
#2
A di Coste, F Occasi, G De Castro, A M Zicari, R Galandrini, A Giuffrida, L Indinnimeo, M Duse
BACKGROUND: The diagnostic and therapeutic approach to grass pollen allergy is now possible by detecting specific IgE (sIgE) to its allergenic components. AIM: To evaluate the correlation between the sensitisation to different molecular Phleum pratense (Phl p) allergens and clinical efficacy of SLIT. METHODS: The pilot study included 36 patients affected by allergic rhinoconjunctivitis, all treated with SLIT actively. We performed serum analysis of sIgE to Phl p 1, 2, 4, 5, 6, 7, 11 and 12...
April 11, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28348871/ngmaster-in-silico-multi-antigen-sequence-typing-for-neisseria-gonorrhoeae
#3
Jason C Kwong, Anders Gonçalves da Silva, Kristin Dyet, Deborah A Williamson, Timothy P Stinear, Benjamin P Howden, Torsten Seemann
Whole-genome sequencing (WGS) provides the highest resolution analysis for comparison of bacterial isolates in public health microbiology. However, although increasingly being used routinely for some pathogens such as Listeria monocytogenes and Salmonella enterica, the use of WGS is still limited for other organisms, such as Neisseria gonorrhoeae. Multi-antigen sequence typing (NG-MAST) is the most widely performed typing method for epidemiological surveillance of gonorrhoea. Here, we present NGMASTER, a command-line software tool for performing in silico NG-MAST on assembled genome data...
August 2016: Microbial Genomics
https://www.readbyqxmd.com/read/28345280/otoprotective-effects-of-mouse-nerve-growth-factor-in-dba-2j-mice-with-early-onset-progressive-hearing-loss
#4
Qingzhu Wang, Hongchun Zhao, Tihua Zheng, Wenjun Wang, Xiaolin Zhang, Andi Wang, Bo Li, Yanfei Wang, Qingyin Zheng
As it displays progressive hair-cell loss and degeneration of spiral ganglion neurons (SGNs) characterized by early-onset progressive hearing loss (ePHL), DBA/2J is an inbred mouse strain widely used in hearing research. Mouse nerve growth factor (mNGF), as a common exogenous nerve growth factor (NGF), has been studied extensively for its ability to promote neuronal survival and growth. To determine whether mNGF can ameliorate progressive hearing loss (PHL) in DBA/2J mice, saline or mNGF was given to DBA/2J mice of either sex by daily intramuscular injection from the 1st to the 9th week after birth...
March 27, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28334931/rgf1p-rho1p-gef-is-required-for-double-strand-break-repair-in-fission-yeast
#5
Elvira Manjón, Tomás Edreira, Sofía Muñoz, Yolanda Sánchez
Rho GTPases are conserved molecules that control cytoskeletal dynamics. These functions are expedited by Rho GEFs that stimulate the release of GDP to enable GTP binding, thereby allowing Rho proteins to initiate intracellular signaling. How Rho GEFs and Rho GTPases protect cells from DNA damage is unknown. Here, we explore the extreme sensitivity of a deletion mutation in the Rho1p exchange factor Rgf1p to the DNA break/inducing antibiotic phleomycin (Phl). The Rgf1p mutant cells are defective in reentry into the cell cycle following the induction of severe DNA damage...
May 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28281544/the-need-for-strengthening-the-influenza-virus-detection-ability-of-hospital-clinical-laboratories-an-investigation-of-the-2009-pandemic
#6
Shigui Yang, Yuqing Zhou, Yuanxia Cui, Cheng Ding, Jie Wu, Min Deng, Chencheng Wang, Xiaoqing Lu, Xiaoxiao Chen, Yiping Li, Dongyan Shi, Fenfang Mi, Lanjuan Li
Most hospital clinical laboratories (HCLs) in China are unable to perform influenza virus detection. It remains unclear whether the influenza detection ability of HCLs influences the early identification and mortality rate of influenza. A total of 739 hospitalized patients with 2009 influenza A (H1N1) virus treated at 65 hospitals between May and December, 2009, in Zhejiang, China, were included based on identifications by HCLs and by public health laboratories (PHLs) of the Centers for Disease Control and Prevention...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28242203/separation-of-saccharides-from-prehydrolysis-liquor-of-lignocellulose-to-upgrade-dissolving-pulp-mill-into-biorefinery-platform
#7
Guoyu Tian, Yingjuan Fu, Jingshun Zhuang, Zhaojiang Wang, Qun Li
In this work, a competitive process consisting of polyelectrolyte flocculation, active carbon absorption, and ion exchange was developed for hemicelluloses-derived saccharides (HDSs) purification from prehydrolysis liquor (PHL) of lignocellulose. Results showed that colloidal lignin counted for 20% of non-saccharide compounds (NSCs) and could be eliminated by flocculation at 500mg/L polyaluminium chloride and 50mg/L anionic polyacrylamide. Active carbon was very effective for decoloration of flocculation-treated PHL, but showed limited absorption selectivity toward NSCs...
February 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28236469/treatment-with-grass-allergen-peptides-improves-symptoms-of-grass-pollen-induced-allergic-rhinoconjunctivitis
#8
Anne K Ellis, Charles W Frankish, Robyn E O'Hehir, Kristen Armstrong, Lisa Steacy, Mark Larché, Roderick P Hafner
BACKGROUND: Synthetic peptide immunoregulatory epitopes are a new class of immunotherapy to treat allergic rhinoconjunctivitis (ARC). Grass allergen peptides, comprising 7 synthetic T-cell epitopes derived from Cyn d 1, Lol p 5, Dac g 5, Hol l 5, and Phl p 5, is investigated for treatment of grass pollen-induced ARC. OBJECTIVE: We sought to evaluate the efficacy, safety, and tolerability of intradermally administered grass allergen peptides. METHODS: A multicenter, randomized, double-blind, placebo-controlled study evaluated 3 regimens of grass allergen peptides versus placebo in patients with grass pollen-induced allergy (18-65 years)...
February 15, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28231234/notes-from-the-field-francisella-tularensis-type-b-infection-from-a-fish-hook-injury-minnesota-2016
#9
Tory Whitten, Jenna Bjork, Dave Neitzel, Kirk Smith, Maureen Sullivan, Joni Scheftel
On June 27, 2016, the Minnesota Department of Health (MDH) Public Health Laboratory (PHL) was notified of a suspected Francisella tularensis isolate cultured at a hospital laboratory. The isolate was confirmed as F. tularensis type B at MDH PHL by reverse transcription-polymerase chain reaction, culture, and direct fluorescent antibody testing. Francisella tularensis subspecies tularensis (type A) and holarctica (type B) bacteria are the causative agents of tularemia.
February 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28230245/ct-guided-percutaneous-hookwire-localization-increases-the-efficacy-and-safety-of-vats-for-pulmonary-nodules
#10
Theo J Klinkenberg, Lars Dinjens, Rienhart F E Wolf, Anthonie J van der Wekken, Caroline van de Wauwer, Geertruida H de Bock, Wim Timens, Massimo A Mariani, Harry J M Groen
BACKGROUND AND OBJECTIVES: The diagnosis of pulmonary nodules of unknown origin is challenging, and such nodules are not always suitable for transthoracic needle biopsy. With the advent of video assisted thoracic surgery (VATS) and CT-guided percutaneous hookwire localization (CT-PHL) we hypothesized that the combination of these two procedures will improve early diagnosis. METHODS: Selection criteria were a nodule not well approachable with fine needle biopsy and the therapeutic consequences of a diagnosis as assessed by the multidisciplinary oncology board...
February 23, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28229191/-18-f-fdg-pet-ct-imaging-versus-bone-marrow-biopsy-in-pediatric-hodgkin-s-lymphoma-a-quantitative-assessment-of-marrow-uptake-and-novel-insights-into-clinical-implications-of-marrow-involvement
#11
Aamna Hassan, Maimoona Siddique, Humayun Bashir, Saima Riaz, Rabia Wali, Asma Mahreen, M Khalid Nawaz
OBJECTIVE: To evaluate whether positron emission tomography/computed tomography using fluorine-18 fluoro-deoxyglucose ((18)F-FDG PET-CT) predicts bone marrow involvement (BMI) in pediatric Hodgkin's lymphoma (pHL) with sufficient accuracy to supplant routine staging bone marrow biopsy (BMB), and to assess the clinical importance of marrow disease by comparing the prognosis of stage IV HL with BMI versus that without BMI. METHODS: Data were retrospectively analyzed for all cases of pHL between July 2010 and June 2015 referred for staging (18)F-FDG PET-CT scan and BMB...
February 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28153352/the-impact-of-age-on-serum-allergen-specific-ige-to-inhaled-molecular-components
#12
M A Tosca, M Silvestri, R Olcese, A Pistorio, G A Rossi, G Ciprandi
BACKGROUND: Respiratory allergy is characterised by an IgE-mediated reaction. The immune system functions, including IgE production, progressively decline over time, such as growing up and ageing. Molecular-based allergy diagnostic defines sensitisation profile. This study aimed to evaluate the impact of age on serum allergen-specific IgE to molecular component levels in a large sample of subjects. METHODS: Serum IgE to: Phl p1, Bet v1, Ole e1, Cup a1, Par j2, Can f1, Der p2, and Fel d1 were assessed by ISAC method...
May 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28151888/pediatric-hodgkin-lymphoma-predictive-value-of-interim-18f-fdg-pet-ct-in-therapy-response-assessment
#13
Cristina Ferrari, Artor Niccoli Asabella, Nunzio Merenda, Corinna Altini, Margherita Fanelli, Paola Muggeo, Francesco De Leonardis, Teresa Perillo, Nicola Santoro, Giuseppe Rubini
We investigated the prognostic value of interim F-FDG PET/CT (PET-2) in pediatric Hodgkin lymphoma (pHL), evaluating both visual and semiquantitative analysis.Thirty pHL patients (age ≤16) underwent serial F-FDG PET/CT: at baseline (PET-0), after 2 cycles of chemotherapy (PET-2) and at the end of first-line chemotherapy (PET-T). PET response assessment was carried out visually according to the Deauville Score (DS), as well as semiquantitatively by using the semiquantitative parameters reduction from PET-0 to PET-2 (ΔΣSUVmax0-2, ΔΣSUVmean0-2)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28119260/percutaneous-liver-biopsy-retrospective-study-of-primary-and-secondary-hepatic-lymphoma-in-twenty-one-patients
#14
Yan-Feng Bai, Ji-Min Liu, Xiu-Ming Zhang, Chao-Zhe Jiang, Xiao Xu, Shu-Sen Zheng
BACKGROUND: Hepatic lymphoma (HL) is categorized as primary and secondary hepatic lymphoma (PHL and SHL). This disorder can present as hepatic mass or mass-like lesion. Chemotherapy often is the first line treatment for patients with HL. Thus, an accurate pre-management histological diagnosis is essential to potentially improve clinical outcomes. The present study was to explore the prevalence of HL in ultrasound guided liver biopsies for hepatic mass or mass-like lesions, to investigate HL associated clinicopathological features, to raise the awareness of early recognition and proper diagnosis of this entity, and to assess specimen adequacy in needle core biopsy...
February 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28093528/a-b-cell-epitope-peptide-derived-from-the-major-grass-pollen-allergen-phl-p-1-boosts-allergen-specific-secondary-antibody-responses-without-allergen-specific-t-cell-help
#15
Meena Narayanan, Raphaela Freidl, Margarete Focke-Tejkl, Ulrike Baranyi, Thomas Wekerle, Rudolf Valenta, Birgit Linhart
More than 40% of allergic patients suffer from grass pollen allergy. Phl p 1, the major timothy grass pollen allergen, belongs to the cross-reactive group 1 grass pollen allergens that are thought to initiate allergic sensitization to grass pollen. Repeated allergen encounter boosts allergen-specific IgE production and enhances clinical sensitivity in patients. To investigate immunological mechanisms underlying the boosting of allergen-specific secondary IgE Ab responses and the allergen epitopes involved, a murine model for Phl p 1 was established...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28076752/methotrexate-associated-primary-hepatic-malignant-lymphoma-following-hepatectomy-a-case-report
#16
Daisuke Takei, Tomoyuki Abe, Hironobu Amano, Naomichi Hirano, Tsuyoshi Kobayashi, Hideki Ohdan, Toshinori Kondo, Masahiro Nakahara, Toshio Noriyuki
INTRODUCTION: Recently, immunosuppressant-associated malignant lymphoma (ML) cases have been increasing along with the development of several effective immunosuppressant drugs for rheumatoid arthritis (RA). Among methotrexate (MTX)-associated lymphoproliferative disorders, primary hepatic lymphoma (PHL) in patients with RA following surgical resection has not been reported previously. PRESENTATION OF CASE: A 65-year-old woman who is a hepatitis B virus carrier with a history of RA was admitted...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27921157/assessment-of-pisotriquetral-misalignment-with-magnetic-resonance-imaging-is-it-associated-with-trauma
#17
Hee-Dong Chae, Hye Jin Yoo, Sung Hwan Hong, Ja-Young Choi, Heung Sik Kang
OBJECTIVE: Our objective was to determine whether there is an association between pisotriquetral (PT) malalignment and acute distal radius fracture by using magnetic resonance imaging (MRI). METHODS: We evaluated 138 patients who underwent 3-T MRI of the wrists. Group A comprised 85 patients with acute distal radius fracture, and group B comprised 53 patients without trauma. PT interval and angle and pisiform excursion were measured on oblique axial and sagittal multiplanar reformats...
December 5, 2016: European Radiology
https://www.readbyqxmd.com/read/27890427/internal-and-external-generalizability-of-temporal-dose-response-relationships-for-xerostomia-following-imrt-for-head-and-neck-cancer
#18
Maria Thor, Adepitan A Owosho, Haley D Clark, Jung Hun Oh, Nadeem Riaz, Allan Hovan, Jillian Tsai, Steven D Thomas, Sae Hee K Yom, Jonn S Wu, Joseph M Huryn, Vitali Moiseenko, Nancy Y Lee, Cherry L Estilo, Joseph O Deasy
BACKGROUND AND PURPOSE: To study internal and external generalizability of temporal dose-response relationships for xerostomia after intensity-modulated radiotherapy (IMRT) for head and neck cancer, and to investigate potential amendments of the QUANTEC guidelines. MATERIAL AND METHODS: Objective xerostomia was assessed in 121 patients (nCohort1=55; nCohort2=66) treated to 70Gy@2Gy in 2006-2015. Univariate and multivariate analyses (UVA, MVA with 1000 bootstrap populations) were conducted in Cohort1, and generalizability of the best-performing MVA model was investigated in Cohort2 (performance: AUC, p-values, and Hosmer-Lemeshow p-values (pHL))...
February 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27863036/newborn-hearing-screening-in-prematurity-fate-of-screening-failures-and-auditory-maturation
#19
H C Yang, C M Sung, D J Shin, Y B Cho, C H Jang, H-H Cho
OBJECTIVES: The purpose of this study was to identify delayed auditory maturation and the fate of premature infants who failed the newborn hearing screening (NHS) in neonatal intensive care unit. MATERIALS AND METHODS: A total of 1375 neonates underwent NHS using the transient evoked otoacoustic emission (TEOAE) in a tertiary hospital between 2007 and 2010 according to the Joint Committee on Infant Hearing guidelines. In addition, a structured telephone survey was given to caregivers of infants who were lost to follow-up NHS...
June 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27861391/effect-of-age-and-sex-on-retinal-layer-thickness-and-volume-in-normal-eyes
#20
Jae Yon Won, Sung Eun Kim, Young-Hoon Park
The aim of the study was to evaluate the effect of sex and age on the thickness of the retinal layer in normal eyes using spectral-domain optical coherence tomography (SD-OCT).Fifty healthy subjects between the ages of 20 and 80 had their retinal layers measured using SD-OCT at Seoul St. Mary's Hospital. Mean thickness and volume were measured for 9 retinal layers in the fovea, the pericentral ring, and the peripheral ring. The differences of sex- and age-related thickness and volume in each retinal layer were analyzed...
November 2016: Medicine (Baltimore)
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