keyword
MENU ▼
Read by QxMD icon Read
search

Crispe

keyword
https://www.readbyqxmd.com/read/27932254/investigating-possible-biological-targets-of-bj-crp-the-first-cysteine-rich-secretory-protein-crisp-isolated-from-bothrops-jararaca-snake-venom
#1
Marina E Lodovicho, Tássia R Costa, Carolina P Bernardes, Danilo L Menaldo, Karina F Zoccal, Sante E Carone, José C Rosa, Manuela B Pucca, Felipe A Cerni, Eliane C Arantes, Jan Tytgat, Lúcia H Faccioli, Luciana S Pereira-Crott, Suely V Sampaio
Cysteine-rich secretory proteins (CRISPs) are commonly described as part of the protein content of snake venoms, nevertheless, so far, little is known about their biological targets and functions. Our study describes the isolation and characterization of Bj-CRP, the first CRISP isolated from Bothrops jararaca snake venom, also aiming at the identification of possible targets for its actions. Bj-CRP was purified using three chromatographic steps (Sephacryl S-200, Source 15Q and C18) and showed to be an acidic protein of 24...
December 5, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27926996/small-molecule-modulator-of-sigma-2-receptor-is-neuroprotective-and-reduces-cognitive-deficits-and-neuro-inflammation-in-experimental-models-of-alzheimer-s-disease
#2
Bitna Yi, James J Sahn, Pooneh Memar Ardestani, Andrew K Evans, Luisa Scott, Jessica Z Chan, Sangeetha Iyer, Ashley Crisp, Gabriella Zuniga, Jonathan Pierce-Shimomura, Stephen F Martin, Mehrdad Shamloo
Accumulating evidence suggests that modulating the sigma 2 receptor (Sig2R) can provide beneficial effects for neurodegenerative diseases. Herein, we report the identification of a novel class of Sig2R binding ligands and their cellular and in vivo activity in experimental models of Alzheimer's disease (AD). We report that SAS-0132 and DKR-1051, selective ligands of Sig2R, modulate intracellular Ca(2+) levels in human SK-N-SH neuroblastoma cells. The Sig2R antagonists SAS-0132 and JVW-1009 are neuroprotective in a C...
December 7, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27882522/the-early-career-psychiatrist-and-the-psychotherapeutic-identity
#3
Glen O Gabbard, Holly Crisp-Han
No abstract text is available yet for this article.
November 23, 2016: Academic Psychiatry
https://www.readbyqxmd.com/read/27879517/dux4-immunohistochemistry-is-a-highly-sensitive-and-specific-marker-for-cic-dux4-fusion-positive-round-cell-tumor
#4
Bradford Siegele, Jon Roberts, Jennifer O Black, Erin Rudzinski, Sara O Vargas, Csaba Galambos
The histologic differential diagnosis of pediatric and adult round cell tumors is vast and includes the recently recognized entity CIC-DUX4 fusion-positive round cell tumor. The diagnosis of CIC-DUX4 tumor can be suggested by light microscopic and immunohistochemical features, but currently, definitive diagnosis requires ancillary genetic testing such as conventional karyotyping, fluorescence in situ hybridization, or molecular methods. We sought to determine whether DUX4 expression would serve as a fusion-specific immunohistochemical marker distinguishing CIC-DUX4 tumor from potential histologic mimics...
November 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27855938/acrylamide-forming-potential-of-potatoes-grown-at-different-locations-and-the-ratio-of-free-asparagine-to-reducing-sugars-at-which-free-asparagine-becomes-a-limiting-factor-for-acrylamide-formation
#5
Nira Muttucumaru, Stephen J Powers, J Stephen Elmore, Andrew Dodson, Adrian Briddon, Donald S Mottram, Nigel G Halford
Acrylamide is produced from free asparagine and reducing sugars during high-temperature cooking and food processing, and potato products are major contributors to dietary acrylamide intake. The present study analysed twenty varieties of potatoes grown at two sites (Doncaster and Woburn) in the United Kingdom to assess the effect of location of cultivation on acrylamide-forming potential. Analysis of variance revealed a full site by variety nested within type (French fry, boiling and crisping) by storage interaction for acrylamide (p<0...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27825912/purification-and-characterization-of-crisp-3-from-human-seminal-plasma-and-its-real-time-binding-kinetics-with-psp94
#6
Jenifer H Anklesaria, Rushika R Pandya, Bhakti R Pathak, Smita D Mahale
Cysteine-rich secretory proteins (CRISPs) have been postulated to have a role in male reproduction and prostate pathophysiology. Of the mammalian CRISPs, CRISP-3 levels in particular have been shown to be upregulated in prostate cancer. Efforts have been made to obtain highly pure CRISP-3 for gaining structure-function information of this protein. However, well characterized and highly pure protein is not available yet. CRISPs from snake venom have been purified using prostate secretory protein of 94 amino acids (PSP94) has been reported earlier...
October 26, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27825288/calendars-in-the-brain-their-perceptual-characteristics-and-possible-neural-substrate
#7
Vilayanur S Ramachandran, Melissa Vajanaphanich, Chaipat Chunharas
When we visualize a calendar, we have a vague impression of a rectangular grid hovering in front. But 1% of the population "see" vivid, crisp "calendar form" - e.g. an odd V shape as in subject ML. We found that (1) ML could "read off", months of her calendar - or alternate months - backward, unlike controls; (2) her eyes and index finger unconsciously "tracked" her reading; (3) her calendar moved with her gaze and tilted with her head; (4) after looking at a contracting spiral, her calendar expanded. In a second subject EA, the calendar was body centered and the access to episodic memories was partially "blocked" when she "looked away"...
October 2016: Neurocase
https://www.readbyqxmd.com/read/27811306/comparison-of-stroke-volume-evolution-on-diffusion-weighted-imaging-and-fluid-attenuated-inversion-recovery-following-endovascular-thrombectomy
#8
Christian Federau, Soren Christensen, Michael Mlynash, Jenny Tsai, Sun Kim, Greg Zaharchuk, Manabu Inoue, Matus Straka, Nishant K Mishra, Stephanie Kemp, Maarten G Lansberg, Gregory W Albers
BACKGROUND: To compare the evolution of the infarct lesion volume on both diffusion-weighted imaging and fluid-attenuated inversion recovery in the first five days after endovascular thrombectomy. METHODS: We included 109 patients from the CRISP and DEFUSE 2 studies. Stroke lesion volumes obtained on diffusion-weighted imaging and fluid-attenuated inversion recovery images both early post-procedure (median 18 h after symptom onset) and day 5, were compared using median, interquartile range, and correlation plots...
November 3, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27796426/primary-care-providers-attitudes-knowledge-and-practice-patterns-regarding-pelvic-floor-disorders
#9
Donna Mazloomdoost, Lauren B Westermann, Catrina C Crisp, Susan H Oakley, Steven D Kleeman, Rachel N Pauls
INTRODUCTION AND HYPOTHESIS: Understanding barriers to seeking care for pelvic floor disorders is necessary. We sought to assess familiarity with pelvic floor disorders, as well as identify screening and referral patterns among primary care providers. METHODS: This Institutional Review Board approved study was distributed through a secure online server (SurveyMonkey®). Primary care providers within a large healthcare system were invited to participate in a 14-question survey regarding the prevalence, diagnosis, and treatment of urinary incontinence (UI), overactive bladder (OAB) syndrome, and pelvic organ prolapse (POP)...
October 28, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27791138/laminin-targeting-of-a-peripheral-nerve-highlighting-peptide-enables-degenerated-nerve-visualization
#10
Heather L Glasgow, Michael A Whitney, Larry A Gross, Beth Friedman, Stephen R Adams, Jessica L Crisp, Timon Hussain, Andreas P Frei, Karel Novy, Bernd Wollscheid, Quyen T Nguyen, Roger Y Tsien
Target-blind activity-based screening of molecular libraries is often used to develop first-generation compounds, but subsequent target identification is rate-limiting to developing improved agents with higher specific affinity and lower off-target binding. A fluorescently labeled nerve-binding peptide, NP41, selected by phage display, highlights peripheral nerves in vivo. Nerve highlighting has the potential to improve surgical outcomes by facilitating intraoperative nerve identification, reducing accidental nerve transection, and facilitating repair of damaged nerves...
October 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27788363/rough-interval-based-multicriteria-decision-analysis-for-remediation-of-1-1-dichloroethane-contaminated-groundwater
#11
Lixia Ren, Li He, Hongwei Lu, Jing Li
A rough-interval-based multicriteria decision analysis method (RI-MCDA) is developed for supporting the selection of remediation strategies for 1,1-dichloroethane contaminated sites. The concept of ''rough interval'' is introduced in the design framework to represent dual-uncertain parameters. Three rough-interval scenarios generated through pair-wise combining the values under three confidence levels (i.e. 68.3%, 95.4% and 99.7%) and one deterministic scenario adopted crisp numbers for parameters are introduced into the framework...
October 24, 2016: Chemosphere
https://www.readbyqxmd.com/read/27786268/hcv-core-protein-inhibits-polarization-and-activity-of-both-m1-and-m2-macrophages-through-the-tlr2-signaling-pathway
#12
Qianqian Zhang, Yang Wang, Naicui Zhai, Hongxiao Song, Haijun Li, Yang Yang, Tianyang Li, Xiaolin Guo, Baorong Chi, Junqi Niu, Ian Nicholas Crispe, Lishan Su, Zhengkun Tu
Hepatitis C virus (HCV) establishes persistent infection in most infected patients, and eventually causes chronic hepatitis, cirrhosis, and hepatocellular carcinoma in some patients. Monocytes and macrophages provide the first line of defense against pathogens, but their roles in HCV infection remains unclear. We have reported that HCV core protein (HCVc) manipulates human blood-derived dendritic cell development. In the present study, we tested whether HCVc affects human blood-derived monocyte differentiating into macrophages...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27780763/classification-schemes-for-carcinogenicity-based-on-hazard-identification-have-become-outmoded-and-serve-neither-science-nor-society
#13
Alan R Boobis, Samuel M Cohen, Vicki L Dellarco, John E Doe, Penelope A Fenner-Crisp, Angelo Moretto, Timothy P Pastoor, Rita S Schoeny, Jennifer G Seed, Douglas C Wolf
Classification schemes for carcinogenicity based solely on hazard-identification such as the IARC monograph process and the UN system adopted in the EU have become outmoded. They are based on a concept developed in the 1970s that chemicals could be divided into two classes: carcinogens and non-carcinogens. Categorization in this way places into the same category chemicals and agents with widely differing potencies and modes of action. This is how eating processed meat can fall into the same category as sulfur mustard gas...
December 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27777178/proteomic-analysis-of-venom-variability-and-ontogeny-across-the-arboreal-palm-pitvipers-genus-bothriechis
#14
Davinia Pla, Libia Sanz, Mahmood Sasa, Manuel E Acevedo, Quetzal Dwyer, Jordi Durban, Alicia Pérez, Yania Rodriguez, Bruno Lomonte, Juan J Calvete
: Bothriechis is a genus of eleven currently recognized slender and arboreal venomous snakes, commonly called palm-pitvipers that range from southern Mexico to northern South America. Despite dietary studies suggesting that palm-pitvipers are generalists with an ontogenetic shift toward endothermic prey, venom proteomic analyses have revealed remarkable divergence between the venoms of the Costa Rican species, B. lateralis, B. schlegelii, B. supraciliaris, and B. nigroviridis. To achieve a more complete picture of the venomic landscape across Bothriechis, the venom proteomes of biodiversity of the northern Middle American highland palm-pitvipers, B...
October 21, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27753880/ish-ada-01-critical-role-of-telomerase-in-regulating-cerebral-vascular-function-and-redox-environment
#15
Karima Ait-Aissa, Joseph Hockenberry, David Gutterman, Aron Geurts, Andreas Beyer
OBJECTIVE: Flow mediated dilation (FMD) is the most physiological relevant form of endothelial-mediated vasodilation. Our laboratory has previously shown that telomerase, a ribo-nucleoprotein that counteracts telomere shortening, has a protective effect on endothelial function under conditions of oxidative stress in the human microcirculation. In the presence of coronary artery disease, decreased telomerase activity contributes to a shift in the mediator of FMD from atheroprotective nitric oxide (NO) to pro-inflammatory and atherogenic hydrogen peroxide (H2O2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27746003/expression-and-localization-of-cysteine-rich-secretory-protein-3-crisp-3-in-the-prepubertal-and-postpubertal-male-horse
#16
C E Fedorka, K E Scoggin, E L Squires, B A Ball, M H T Troedsson
The seminal plasma protein, cysteine-rich secretory protein-3 (CRISP-3), has been correlated with increased fertility and first-cycle conception rates, and has been suggested to be involved in the modulation of polymorphonuclear neutrophil and phagocytosis of spermatozoa during the inflammatory response to breeding in the horse. Previous research demonstrated that equine CRISP-3 is located in both the ampulla of the vas deferens and the seminal vesicles. However, this was done with nonquantitative laboratory techniques...
September 21, 2016: Theriogenology
https://www.readbyqxmd.com/read/27734483/speak-up-barriers-to-challenging-erroneous-decisions-of-seniors-in-anaesthesia
#17
T Beament, S J Mercer
'Speaking up' or the ability to effectively challenge erroneous decisions is essential to preventing harm. This mixed-methods study in two parts explores the concept of 'barriers to challenging seniors' for anaesthetic trainees, and proposes a conceptual framework. Using a fully immersive simulation scenario with unanticipated airway difficulty, we investigated how junior anaesthetists (one to two years of training) challenged a scripted error. We also conducted focus groups with senior trainees (three to seven years of training) and undertook a 'thematic network analysis' of responses...
November 2016: Anaesthesia
https://www.readbyqxmd.com/read/27726950/manifesto-for-a-healthy-and-health-creating-society
#18
Nigel Crisp, David Stuckler, Richard Horton, Victor Adebowale, Sue Bailey, Maureen Baker, John Bell, John Bird, Carol Black, Jane Campbell, Janet Davies, Heather Henry, Robert Lechler, Andrew Mawson, Patrick H Maxwell, Martin McKee, Cathy Warwick
Brexit and the troubled state of the NHS call for re-thinking the UK's approach to health. The EU referendum vote reveals deep social divisions as well as presenting the country with important decisions and negotiations about the future. At the same time, health problems are growing; the NHS faces severe financial constraints and appears to lurch from crisis to crisis, with leaving the European Union likely to exacerbate many problems including staffing issues across the whole sector. However, new scientific developments and digital technology offer societies everywhere massive and unprecedented opportunities for improving health...
October 6, 2016: Lancet
https://www.readbyqxmd.com/read/27698471/anti-tubulin-drugs-conjugated-to-anti-erbb-antibodies-selectively-radiosensitize
#19
Stephen R Adams, Howard C Yang, Elamprakash N Savariar, Joe Aguilera, Jessica L Crisp, Karra A Jones, Michael A Whitney, Scott M Lippman, Ezra E W Cohen, Roger Y Tsien, Sunil J Advani
Tumour resistance to radiotherapy remains a barrier to improving cancer patient outcomes. To overcome radioresistance, certain drugs have been found to sensitize cells to ionizing radiation (IR). In theory, more potent radiosensitizing drugs should increase tumour kill and improve patient outcomes. In practice, clinical utility of potent radiosensitizing drugs is curtailed by off-target side effects. Here we report potent anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize to tumours based on surface receptor expression...
October 4, 2016: Nature Communications
https://www.readbyqxmd.com/read/27686063/the-effect-of-select-seminal-plasma-proteins-on-endometrial-mrna-cytokine-expression-in-mares-susceptible-to-persistent-mating-induced-endometritis
#20
C E Fedorka, K E Scoggin, E M Woodward, E L Squires, B A Ball, Mht Troedsson
In the horse, breeding induces a transient endometrial inflammation. A subset of mares are unable to resolve this inflammation, and they are considered susceptible to persistent mating-induced endometritis PMIE Select seminal plasma proteins cysteine-rich secretory protein-3 (CRISP-3) and lactoferrin have been shown to affect the innate immune response to sperm in vitro. The objective of this study was to determine whether the addition of CRISP-3 and lactoferrin at the time of insemination had an effect on the mRNA expression of endometrial cytokines in susceptible mares after breeding...
September 30, 2016: Reproduction in Domestic Animals, Zuchthygiene
keyword
keyword
83539
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"