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https://www.readbyqxmd.com/read/29676932/exoplanet-biosignatures-a-framework-for-their-assessment
#1
David C Catling, Joshua Krissansen-Totton, Nancy Y Kiang, David Crisp, Tyler D Robinson, Shiladitya DasSarma, Andrew J Rushby, Anthony Del Genio, William Bains, Shawn Domagal-Goldman
Finding life on exoplanets from telescopic observations is an ultimate goal of exoplanet science. Life produces gases and other substances, such as pigments, which can have distinct spectral or photometric signatures. Whether or not life is found with future data must be expressed with probabilities, requiring a framework of biosignature assessment. We present a framework in which we advocate using biogeochemical "Exo-Earth System" models to simulate potential biosignatures in spectra or photometry...
April 20, 2018: Astrobiology
https://www.readbyqxmd.com/read/29675969/exercise-induced-pulmonary-haemorrhage-in-thoroughbred-racehorses-a-longitudinal-study
#2
E J Crispe, C J Secombe, D I Perera, A A Manderson, B A Turlach, G D Lester
BACKGROUND: Exercise induced pulmonary haemorrhage (EIPH) is considered a progressive disease based on histopathology, but it is unknown if tracheobronchoscopic EIPH severity worsens over time. OBJECTIVES: The aim of this study was to examine tracheobronchoscopic EIPH changes over time in a population of Thoroughbred racehorses. A secondary aim was to identify factors that affect changes in tracheobronchoscopic EIPH severity between observations. STUDY DESIGN: Prospective, longitudinal, observational cross-sectional study...
April 20, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29664600/asymmetric-optical-transitions-determine-the-onset-of-carrier-multiplication-in-lead-chalcogenide-quantum-confined-and-bulk-crystals
#3
Frank C M Spoor, Gianluca Grimaldi, Christophe Delerue, Wiel H Evers, Ryan W Crisp, Pieter Geiregat, Zeger Hens, Arjan J Houtepen, Laurens D A Siebbeles
Carrier multiplication is a process in which one absorbed photon excites two or more electrons. This is of great promise to increase the efficiency of photovoltaic devices. Until now, the factors that determine the onset energy of carrier multiplication have not been convincingly explained. We show experimentally that the onset of carrier multiplication in lead chalcogenide quantum confined and bulk crystals is due to asymmetric optical transitions. In such transitions most of the photon energy in excess of the band gap is given to either the hole or the electron...
April 17, 2018: ACS Nano
https://www.readbyqxmd.com/read/29660198/food-advertising-on-australian-television-frequency-duration-and-monthly-pattern-of-advertising-from-a-commercial-network-four-channels-for-the-entire-2016
#4
Lisa G Smithers, Dandara G Haag, Benjamin Agnew, John Lynch, Matthew Sorell
AIM: To estimate the frequency, duration and monthly pattern of discretionary food advertising on Australian free-to-air television. METHODS: We logged 30 000 h of television collected in Adelaide during 2016 from one network that has four channels. The Australian Guide to Healthy Eating was used to identify discretionary foods. Data were examined according to all times, to children's peak viewing times (PVTs) and to when C-(children's) rated programmes may be broadcast...
April 16, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29656017/proteomic-and-toxinological-characterization-of-the-venom-of-the-south-african-ringhals-cobra-hemachatus-haemachatus
#5
Andrés Sánchez, María Herrera, Mauren Villalta, Daniela Solano, Álvaro Segura, Bruno Lomonte, José María Gutiérrez, Guillermo León, Mariángela Vargas
The protein composition and toxinological profile of the venom of the African spitting elapid Hemachatus haemachatus (Ringhals) were characterized by bottom-up proteomics and functional in vitro and in vivo assays. Venom is composed of abundant three-finger toxins (3FTxs; 63.3%), followed by phospholipases A2 (PLA2 s; 22.8%), snake venom metalloproteinases (SVMPs 7.1%), cysteine-rich secretory proteins (CRISPs; 4.1%) and Kunitz type protease inhibitors (KTPIs; 1.5%). 3FTxs are the main responsible for lethality and myotoxicity in mice and in vitro anticoagulant activity...
April 12, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29621846/the-crisp-q-study
#6
Grace Y Kim, Jennifer Walker, Adrian Bickerstaffe, Nadira Hewabandu, Marie Pirotta, Louisa Flander, Mark Jenkins, Jon Emery
This research will inform approaches to communicating risk in CRISP and may be of wider relevance to supporting informed decisions about cancer screening. <div class="hor-line">&nbsp;</div>.
March 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29581341/time-from-imaging-to-endovascular-reperfusion-predicts-outcome-in-acute-stroke
#7
Jenny P Tsai, Michael Mlynash, Soren Christensen, Stephanie Kemp, Sun Kim, Nishant K Mishra, Christian Federau, Raul G Nogueira, Tudor G Jovin, Thomas G Devlin, Naveed Akhtar, Dileep R Yavagal, Roland Bammer, Matus Straka, Gregory Zaharchuk, Michael P Marks, Gregory W Albers, Maarten G Lansberg
BACKGROUND AND PURPOSE: This study aims to describe the relationship between computed tomographic (CT) perfusion (CTP)-to-reperfusion time and clinical and radiological outcomes, in a cohort of patients who achieve successful reperfusion for acute ischemic stroke. METHODS: We included data from the CRISP (Computed Tomographic Perfusion to Predict Response in Ischemic Stroke Project) in which all patients underwent a baseline CTP scan before endovascular therapy...
April 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29580111/the-african-american-eye-disease-study-design-and-methods
#8
Roberta McKean-Cowdin, Alicia Fairbrother-Crisp, Mina Torres, Carlos Lastra, Farzana Choudhury, Xuejuan Jiang, Bruce Burkemper, Rohit Varma
PURPOSE: To describe the study design, operational and recruitment strategies, procedures, and baseline characteristics of the African American Eye Disease Study (AFEDS), a population-based assement of the prevalence of visual impairment, ocular disease, visual function, and health-related quality of life in African Americans. METHODS: This population-based, cross-sectional study included over 6000 African Americans 40 years and older residing in and around Inglewood, California...
March 26, 2018: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29579984/inter-correlation-of-apple-firmness-determinations-and-development-of-cross-validated-regression-models-for-prediction-of-sensory-attributes-from-instrumental-and-compositional-analyses
#9
Margaret A Cliff, Masoumeh Bejaei
The texture of apples is paramount for determining fruit quality. This research explored the correlations among firmness determinations from the Sinclair iQ™ Firmness Tester (SiQ™), the Aweta Acoustic Firmness Sensor (AFS), and eight measurements from the Mohr Digi-Test-2 (MDT) instrument. Assessments were conducted on a collection of nine apple cultivars (Ambrosia, Aurora Golden Gala™, Honeycrisp, Fuji, Imperial Gala, McIntosh, Pink Lady™, Silken, Salish™), with a broad range of firmness values, in each of two years...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29575728/the-role-of-mentoring-in-leadership-development
#10
Gloria Crisp, Kelly Alvarado-Young
This chapter discusses the role of mentoring in facilitating leadership development for students throughout the educational pipeline. Related literature is summarized and practical guidance is provided for designing, implementing, and evaluating programs with a focus toward developing students as leaders.
June 2018: New Directions for Student Leadership
https://www.readbyqxmd.com/read/29566794/tau-kinetics-in-neurons-and-the-human-central-nervous-system
#11
Chihiro Sato, Nicolas R Barthélemy, Kwasi G Mawuenyega, Bruce W Patterson, Brian A Gordon, Jennifer Jockel-Balsarotti, Melissa Sullivan, Matthew J Crisp, Tom Kasten, Kristopher M Kirmess, Nicholas M Kanaan, Kevin E Yarasheski, Alaina Baker-Nigh, Tammie L S Benzinger, Timothy M Miller, Celeste M Karch, Randall J Bateman
We developed stable isotope labeling and mass spectrometry approaches to measure the kinetics of multiple isoforms and fragments of tau in the human central nervous system (CNS) and in human induced pluripotent stem cell (iPSC)-derived neurons. Newly synthesized tau is truncated and released from human neurons in 3 days. Although most tau proteins have similar turnover, 4R tau isoforms and phosphorylated forms of tau exhibit faster turnover rates, suggesting unique processing of these forms that may have independent biological activities...
March 21, 2018: Neuron
https://www.readbyqxmd.com/read/29562597/effects-of-different-dietary-interventions-on-calcitriol-parathyroid-hormone-calcium-and-phosphorus-results-from-the-dash-trial
#12
Ahmed Hassoon, Erin D Michos, Edgar R Miller, Zeni Crisp, Lawrence J Appel
The "Dietary Approaches to Stop Hypertension" (DASH) diet, rich in fiber and low-fat dairy, effectively lowers blood pressure. DASH's effect on calcitriol and other markers of bone-mineral metabolism is unknown. This secondary analysis of the DASH trial aimed to determine the effect of dietary patterns on blood concentrations of calcitriol, parathyroid hormone (PTH), ionized calcium, and urinary excretion of calcium and phosphorus. Outcomes were available in 334 participants in the trial. After a 3-week run-in on the control diet, participants were randomized to control, fruits and vegetables (F&amp;V), or DASH diets...
March 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29554783/forensic-hydro-meteorological-analysis-of-an-extreme-flash-flood-the-2016-05-29-event-in-braunsbach-sw-germany
#13
Axel Bronstert, Ankit Agarwal, Berry Boessenkool, Irene Crisologo, Madlen Fischer, Maik Heistermann, Lisei Köhn-Reich, José Andrés López-Tarazón, Thomas Moran, Ugur Ozturk, Christian Reinhardt-Imjela, Dadiyorto Wendi
The flash-flood in Braunsbach in the north-eastern part of Baden-Wuerttemberg/Germany was a particularly strong and concise event which took place during the floods in southern Germany at the end of May/early June 2016. This article presents a detailed analysis of the hydro-meteorological forcing and the hydrological consequences of this event. A specific approach, the "forensic hydrological analysis" was followed in order to include and combine retrospectively a variety of data from different disciplines...
February 28, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29543775/limiting-trans-fats-in-foods-use-of-partially-hydrogenated-vegetable-oils-in-prepacked-foods-in-slovenia
#14
Nina Zupanič, Maša Hribar, Urška Pivk Kupirovič, Anita Kušar, Katja Žmitek, Igor Pravst
Consumption of industrially produced trans -fatty acids (TFAs) is a well-established health risk factor that correlates with the increased risk of developing cardiovascular disease. The recommended TFA intake is as low as possible, within the context of a nutritionally adequate diet. Different countries have introduced different measures to minimize the exposure of their population to TFAs. Previous data have shown that TFA content has significantly decreased in Western European countries, while this was not the case in many Central-Eastern European countries, including Slovenia...
March 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29537884/current-status-of-sperm-functional-genomics-and-its-diagnostic-potential-of-fertility-in-bovine-bos-taurus
#15
Sellappan Selvaraju, Sivashanmugam Parthipan, Lakshminarayana Somashekar, B Krishnan Binsila, Atul P Kolte, Arunachalam Arangasamy, Janivara Parameshwaraiah Ravindra, Stephen A Krawetz
With artificial insemination (AI) and other precision dependent assisted reproductive technologies (ART) being followed in large scale in human and animal reproduction, assessing semen quality and fertilizability is under continuous scrutiny. Various tests have been developed to predict semen quality, but so far no single, highly reliable test is available. In this regard, transcriptomic profiling of spermatozoa assumes significance as it carries the information about spermatogenesis, sperm function, and paternal roles in post-fertilization events...
March 14, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29533524/prebiotic-methylations-and-carbamoylations-generate-non-canonical-rna-nucleosides-as-molecular-fossils-of-an-early-earth
#16
Christina Schneider, Sidney Becker, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Michael Stadlmeier, Thomas Carell
The RNA world hypothesis assumes that life on earth started with small RNA molecules that catalyzed their own formation. Vital to this hypothesis is the need for prebiotic routes towards RNA. Contemporary RNA, however, is not only constructed from the four canonical nucleobases (A, C, G and U), but it contains in addition many chemically modified (non-canonical) bases. A yet open question is if these non-canonical bases were formed in parallel to the canonical bases (chemical origin), or whether they were created later, when life demanded higher functional diversity (biological origin)...
March 13, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29521410/-data-science-in-psychiatry
#17
F E Scheepers, V Menger, K Hagoort
The information society is digitalising at a fast pace. New technology enables the collection of real life and real time information from sources that were inaccessible before. This creates an inordinate amount of dynamic data and, consequently, opportunities to introduce new insights and improvement of treatment in the field of psychiatry.<br/> AIM: To clarify the definition of big data and how a big data approach can reform care into a data driven, patient oriented dynamic system which is constantly learning...
2018: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/29518239/genotyping-of-giardia-duodenalis-in-vegetables-cultivated-with-organic-and-chemical-fertilizer-from-street-markets-and-community-vegetable-gardens-in-a-region-of-southern-brazil
#18
Katyelle Rafael, Ariella A Marchioro, Cristiane M Colli, Bruna T Tiyo, Fernanda F Evangelista, Renata C Bezagio, Ana L Falavigna-Guilherme
Background: In order to investigate the occurrence of Giardia duodenalis and its genotypes in vegetables that are consumed raw, we analyzed samples cultivated with organic or chemical fertilizer, sold in street markets and from community vegetable gardens in an urban area located in Southern Brazil. Methods: We analyzed 130 samples of vegetables such as crisp lettuce, regular lettuce, kale, chicory and rocket, from street markets, and 130 from community gardens...
March 6, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29505764/heligmosomoides-polygyrus-venom-allergen-like-protein-4-hpval-4-is-a-sterol-binding-protein
#19
Oluwatoyin A Asojo, Rabih Darwiche, Selam Gebremedhin, Geert Smant, Jose L Lozano-Torres, Claire Drurey, Jeroen Pollet, Rick M Maizels, Roger Schneiter, Ruud H P Wilbers
Heligmosomoides polygyrus bakeri is a model parasitic hookworm used to study animal and human helminth diseases. During infection, the parasite releases excretory/secretory (ES) products that modulate the immune system of the host. The most abundant protein family in ES products comprises the venom allergen-like proteins (VALs), which are members of the SCP/TAPS (Sperm-coating protein / Tpx / antigen 5 / pathogenesis related-1 / Sc7) superfamily. There are >30 secreted Heligmosomoides polygyrus VAL proteins (HpVALs) and these proteins are characterized by having either one or two 15 kDa CAP (cysteine-rich secretory protein (CRISP) / antigen 5 / pathogenesis related-1) domains...
March 2, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29501266/crystal-structure-ofbrugia-malayi-venom-allergen-like-protein-1-bmval-1-a-vaccine-candidate-for-lymphatic-filariasis
#20
Rabih Darwiche, Fernanda Lugo, Claire Drurey, Koen Varossieau, Geert Smant, Ruud H P Wilbers, Rick M Maizels, Roger Schneiter, Oluwatoyin A Asojo
Brugia malayi is a causative agent of lymphatic filariasis, a major tropical disease. The infective L3 parasite stage releases immunomodulatory proteins including the venom allergen-like proteins (VALs), which are members of the SCP/TAPS (Sperm-coating protein / Tpx / antigen 5 / pathogenesis related-1 / Sc7) superfamily. BmVAL-1 is a major target of host immunity with >90% of infected B. malayi microfilaraemic cases being seropositive for antibodies to BmVAL-1. This study is part of ongoing efforts to characterize the structures and functions of important B...
February 28, 2018: International Journal for Parasitology
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