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https://www.readbyqxmd.com/read/29222525/conserved-gene-microsynteny-unveils-functional-interaction-between-protein-disulfide-isomerase-and-rho-guanine-dissociation-inhibitor-families
#1
Ana I S Moretti, Jessyca C Pavanelli, Patrícia Nolasco, Matthias S Leisegang, Leonardo Y Tanaka, Carolina G Fernandes, João Wosniak, Daniela Kajihara, Matheus H Dias, Denise C Fernandes, Hanjoong Jo, Ngoc-Vinh Tran, Ingo Ebersberger, Ralf P Brandes, Diego Bonatto, Francisco R M Laurindo
Protein disulfide isomerases (PDIs) support endoplasmic reticulum redox protein folding and cell-surface thiol-redox control of thrombosis and vascular remodeling. The family prototype PDIA1 regulates NADPH oxidase signaling and cytoskeleton organization, however the related underlying mechanisms are unclear. Here we show that genes encoding human PDIA1 and its two paralogs PDIA8 and PDIA2 are each flanked by genes encoding Rho guanine-dissociation inhibitors (GDI), known regulators of RhoGTPases/cytoskeleton...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29215511/liposomal-bupivacaine-during-robotic-colpopexy-and-posterior-repair-a-randomized-controlled-trial
#2
Jennifer Yeung, Catrina C Crisp, Donna Mazloomdoost, Steven D Kleeman, Rachel N Pauls
OBJECTIVE: To evaluate the effect of liposomal bupivacaine on postoperative pain among patients undergoing robotic sacrocolpopexy with posterior repair. METHODS: This was a randomized, patient-blinded, placebo-controlled trial of women undergoing robotic sacrocolpopexy with posterior repair. Liposomal bupivacaine or normal saline placebo was injected into laparoscopic and vaginal incisions at completion of surgery. Perioperative care was standardized. Visual analog scales were collected at 4, 18, and 24 hours postoperatively in hospital...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29195997/instrumental-and-sensory-properties-of-pea-protein-fortified-extruded-rice-snacks
#3
Claudia Philipp, Roman Buckow, Pat Silcock, Indrawati Oey
Characteristic attributes of pea-protein fortified, extruded rice snacks were evaluated by mechanical, acoustic and descriptive sensory analysis. The addition of pea protein isolate (0 to 45% (w/w)) to rice flour and extruder screw speed strongly affected the expansion behaviour and therefore, textural attributes of extruded snack products. The sensory panel described the texture of highly expanded extrudates as crisp, while low expanded extrudates were perceived as hard, crunchy and non-crisp. Results of the instrumental and sensory analysis were compared and showed a high correlation between mechanical and sensory hardness (r=0...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29194425/contribution-of-discretionary-foods-and-drinks-to-australian-children-s-intake-of-energy-saturated-fat-added-sugars-and-salt
#4
Brittany J Johnson, Lucinda K Bell, Dorota Zarnowiecki, Anna M Rangan, Rebecca K Golley
Interventions are required to reduce children's consumption of discretionary foods and drinks. To intervene we need to identify appropriate discretionary choice targets. This study aimed to determine the main discretionary choice contributors to energy and key nutrient intakes in children aged 2-18 years. Secondary analyses were performed with population weighted, single 24 h dietary recall data from the 2011-2012 National Nutrition and Physical Activity Survey. Cakes, muffins, and slices; sweet biscuits; potato crisps and similar snacks; and, processed meats and sugar-sweetened drinks were relatively commonly consumed and were within the top three to five contributors to per capita energy, saturated fat, sodium, and/or added sugars...
December 1, 2017: Children
https://www.readbyqxmd.com/read/29191760/thermodynamic-estimate-of-the-number-of-solvent-molecules-displaced-by-a-solute-molecule-for-enthalpy-driven-adsorption-phenobarbital-and-activated-carbons-as-the-model-system
#5
Peng Yu, Dale Eric Wurster
A Modified Crisp Equation, describing the differential Gibbs free energy of the adsorption process, is being proposed, which considers multiple sites available on the surface for adsorption and their relative fractions. The differential Gibbs free energy can be calculated by the van't Hoff Equation, which depends on the affinity constant in the Langmuir-Like Equation. To consider the number of solvent molecules displaced by a solute molecule in the adsorption process, a new derivative of the Langmuir-Like Equation is being proposed as well...
November 27, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29178339/chemical-constituents-of-sweetpotato-genotypes-in-relation-to-textural-characteristics-of-processed-french-fries
#6
Ai Sato, Van-Den Truong, Suzanne D Johanningsmeier, Rong Reynolds, Kenneth V Pecota, G Craig Yencho
Sweetpotato French fries (SPFF) are growing in popularity, however limited information is available on SPFF textural properties in relation to chemical composition. This study investigated the relationship between chemical components of different sweetpotato varieties and textural characteristics of SPFF. Sixteen sweetpotato genotypes were evaluated for (1) chemical constituents; (2) instrumental and sensory textural properties of SPFF; and (3) the relationship between chemical components, instrumental measurements, and sensory attributes...
November 27, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29176743/hcv-immune-evasion-and-regulatory-t-cell-activation-cause-or-consequence
#7
Haijun Li, Tianyang Li, Ian Nicholas Crispe, Zhengkun Tu
No abstract text is available yet for this article.
November 27, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29164814/a-thrombin-receptor-derived-imaging-agent-detects-subclinical-arthritis-in-mice
#8
Beth Friedman, Michael A Whitney, Elamprakash N Savariar, Christa Caneda, Paul Steinbach, Qing Xiong, Dina V Hingorani, Jessica Crisp, Stephen R Adams, Michael Kenner, Csilla N Lippert, Quyen T Nguyen, Monica Guma, Roger Y Tsien, Maripat Corr
OBJECTIVE: Functional imaging of synovitis could improve both early detection of rheumatoid arthritis (RA) and long-term outcomes. Motivated by the intersection of inflammation with coagulation protease activation, we examine coagulation protease activities in arthritic mice with a dual fluorescent Ratiometric thrombin-Activatable Cell Penetrating Peptide (RACPPNleTPRSFL ). METHOD: Mice with chronic transgenic K/BxN arthritis, or with arthritis on Day 1 of passive serum transfer induced arthritis (STIA), were imaged in vivo for Cy5 em: Cy7 em ratiometric fluorescence from proteolytic cleavage and activation of RACPPNleTPRSFL ...
November 22, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29160555/the-effect-of-sleep-disorders-sedating-medications-and-depression-on-cognitive-processing-therapy-outcomes-a-fuzzy-set-qualitative-comparative-analysis
#9
Patricia L Haynes, Sarah E Emert, Dana Epstein, Suzanne Perkins, Sairam Parthasarathy, James Wilcox
Cognitive processing therapy (CPT) for posttraumatic stress disorder (PTSD) is an effortful process requiring engagement in cognitive restructuring. Sleep disorders may lead to avoidance of effortful tasks and cognitive performance deficits. We explored whether sleep disorders, as assessed by polysomnography, were consistently associated with treatment response in combination with other factors. This study included 32 U.S. veterans who were examined both before and after CPT for combat-related PTSD. We employed a novel, case-comparative technique, fuzzy set qualitative comparative analysis (fsQCA), to identify combinations of fuzzy and crisp factors (recipes) that achieve a clinically significant outcome...
November 21, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29159291/continuum-reconfigurable-parallel-robots-for-surgery-shape-sensing-and-state-estimation-with-uncertainty
#10
Patrick L Anderson, Arthur W Mahoney, Robert J Webster
This paper examines shape sensing for a new class of surgical robot that consists of parallel flexible structures that can be reconfigured inside the human body. Known as CRISP robots, these devices provide access to the human body through needle-sized entry points, yet can be configured into truss-like structures capable of dexterous movement and large force application. They can also be reconfigured as needed during a surgical procedure. Since CRISP robots are elastic, they will deform when subjected to external forces or other perturbations...
July 2017: IEEE Robotics and Automation Letters
https://www.readbyqxmd.com/read/29154885/consumers-health-related-perceptions-of-bread-implications-for-labeling-and-health-communication
#11
Pernilla Sandvik, Margaretha Nydahl, Iwona Kihlberg, Ingela Marklinder
There is a wide variety of commercial bread types and the present study identifies potential pitfalls in consumer evaluations of bread from a health perspective. The aim is to describe consumers' health-related perceptions of bread by exploring which health-related quality attributes consumers associate with bread and whether there are differences with regard to age, gender and education level. A postal and web-based sequential mixed-mode survey (n = 1134, 63% responded online and 37% by paper) with open-ended questions and an elicitation task with pictures of commercial breads were used...
November 14, 2017: Appetite
https://www.readbyqxmd.com/read/29143716/the-shelf-space-and-strategic-placement-of-healthy-and-discretionary-foods-in-urban-urban-fringe-and-rural-non-metropolitan-australian-supermarkets
#12
Adrian J Cameron
OBJECTIVE: Supermarkets are a key influence on eating behaviours, but it is unknown if the promotion of food within stores varies on a geographic gradient from urban, to urban-fringe and non-metropolitan areas. The present study aimed to assess the shelf space and strategic placement of healthy and discretionary foods in each of urban, urban-fringe and non-metropolitan Australian supermarkets. Design/Setting In-store audits were conducted in stores from one of the two major Australian supermarket chains in urban (n 19), urban-fringe (n 20) and non-metropolitan (n 26) areas of Victoria...
November 16, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/29132916/insulin-degrading-enzyme-in-the-fight-against-alzheimer-s-disease
#13
REVIEW
Igor V Kurochkin, Enrico Guarnera, Igor N Berezovsky
After decades of research and clinical trials there is still no cure for Alzheimer's disease (AD). While impaired clearance of amyloid beta (Aβ) peptides is considered as one of the major causes of AD, it was recently complemented by a potential role of other toxic amyloidogenic species. Insulin-degrading enzyme (IDE) is the proteolytic culprit of various β-forming peptides, both extracellular and intracellular. On the basis of demonstrated allosteric activation of IDE against Aβ, it is possible to propose a new strategy for the targeted IDE-based cleansing of different toxic aggregation-prone peptides...
November 10, 2017: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29111587/multifractal-approaches-of-the-ring-tensile-rupture-patterns-of-dried-laver-porphyra-as-affected-by-the-relative-humidity
#14
Hwabin Jung, Won Byong Yoon
The effect of water activity (aw ) or the relative humidity (RH) on the tensile rupture properties of dried laver (DL) associated with structures formed with phycocolloids was investigated. The morphological characteristics of tensile ruptured DL samples at various relative humidities were evaluated by multifractal analysis. The RH of the microclimate was controlled from 10% to 90% at 25 °C using supersaturated salt solutions. The sorption isotherm of DL was experimentally obtained and quantitatively analyzed using mathematical models...
November 7, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29100391/gene-expression-information-improves-reliability-of-receptor-status-in-breast-cancer-patients
#15
Michael Kenn, Karin Schlangen, Dan Cacsire Castillo-Tong, Christian F Singer, Michael Cibena, Heinz Koelbl, Wolfgang Schreiner
Immunohistochemical (IHC) determination of receptor status in breast cancer patients is frequently inaccurate. Since it directs the choice of systemic therapy, it is essential to increase its reliability. We increase the validity of IHC receptor expression by additionally considering gene expression (GE) measurements. Crisp therapeutic decisions are based on IHC estimates, even if they are borderline reliable. We further improve decision quality by a responsibility function, defining a critical domain for gene expression...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29081761/imagined-steps-mental-simulation-of-coordinated-rhythmic-movements-effects-on-pro-sociality
#16
Liam Cross, Gray Atherton, Andrew D Wilson, Sabrina Golonka
Rhythmically coordinating with a partner can increase pro-sociality, but pro-sociality does not appear to change in proportion to coordination success, or particular classes of coordination. Pro-social benefits may have more to do with simply coordinating in a social context than the details of the actual coordination (Cross et al., 2016). This begs the question, how stripped down can a coordination task be and still affect pro-sociality? Would it be sufficient simply to imagine coordinating with others? Imagining a social interaction can lead to many of the same effects as actual interaction (Crisp and Turner, 2009)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29071358/tracing-the-evolutionary-history-of-the-cap-superfamily-of-proteins-using-amino-acid-sequence-homology-and-conservation-of-splice-sites
#17
Anup Abraham, Douglas E Chandler
Proteins of the CAP superfamily play numerous roles in reproduction, innate immune responses, cancer biology, and venom toxicology. Here we document the breadth of the CAP (Cysteine-RIch Secretory Protein (CRISP), Antigen 5, and Pathogenesis-Related) protein superfamily and trace the major events in its evolution using amino acid sequence homology and the positions of exon/intron borders within their genes. Seldom acknowledged in the literature, we find that many of the CAP subfamilies present in mammals, where they were originally characterized, have distinct homologues in the invertebrate phyla...
October 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/29058904/formation-of-a-hydroxymethylfurfural-cysteine-adduct-and-its-absorption-and-cytotoxicity-in-caco-2-cells
#18
Qianzhu Zhao, Yueyu Zou, Caihuan Huang, Ping Lan, Jie Zheng, Shiyi Ou
Adducts of 5-hydroxymethylfurfural (HMF)-amino acids are formed during food processing and digestion; the elimination capacity of in vitro intestinal digests of biscuits, instant noodles, and potato crisps for HMF is 652, 727, and 540 μg/g, respectively. However, the safety of these adducts is unknown. In this study, an HMF-cysteine adduct named 1-dicysteinethioacetal-5-hydroxymehtylfurfural (DCH), which was found to be produced in the gastrointestinal tract after HMF intake, was prepared to test its effect toward Caco-2 cells...
October 31, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29054255/predicting-cd4-count-changes-among-patients-on-antiretroviral-treatment-application-of-data-mining-techniques
#19
Mihiretu Kebede, Desalegn Tigabu Zegeye, Berihun Megabiaw Zeleke
BACKGROUND AND OBJECTIVES: To monitor the progress of therapy and disease progression, periodic CD4 counts are required throughout the course of HIV/AIDS care and support. The demand for CD4 count measurement is increasing as ART programs expand over the last decade. This study aimed to predict CD4 count changes and to identify the predictors of CD4 count changes among patients on ART. METHODS: A cross-sectional study was conducted at the University of Gondar Hospital from 3,104 adult patients on ART with CD4 counts measured at least twice (baseline and most recent)...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29051612/the-orbiting-carbon-observatory-oco-2-tracks-2-3-peta-gram-increase-in-carbon-release-to-the-atmosphere-during-the-2014-2016-el-ni%C3%A3-o
#20
Prabir K Patra, David Crisp, Johannes W Kaiser, Debra Wunch, Tazu Saeki, Kazuhito Ichii, Takashi Sekiya, Paul O Wennberg, Dietrich G Feist, David F Pollard, David W T Griffith, Voltaire A Velazco, M De Maziere, Mahesh K Sha, Coleen Roehl, Abhishek Chatterjee, Kentaro Ishijima
The powerful El Niño event of 2015-2016 - the third most intense since the 1950s - has exerted a large impact on the Earth's natural climate system. The column-averaged CO2 dry-air mole fraction (XCO2) observations from satellites and ground-based networks are analyzed together with in situ observations for the period of September 2014 to October 2016. From the differences between satellite (OCO-2) observations and simulations using an atmospheric chemistry-transport model, we estimate that, relative to the mean annual fluxes for 2014, the most recent El Niño has contributed to an excess CO2 emission from the Earth's surface (land + ocean) to the atmosphere in the range of 2...
October 19, 2017: Scientific Reports
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