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https://www.readbyqxmd.com/read/29325770/development-of-a-non-toxic-and-non-denaturing-formulation-process-for-encapsulation-of-sdf-1%C3%AE-into-plga-peg-plga-nanoparticles-to-achieve-sustained-release
#1
Muhammad Haji Mansor, Mathie Najberg, Aurélien Contini, Carmen Alvarez-Lorenzo, Emmanuel Garcion, Christine Jérôme, Frank Boury
No abstract text is available yet for this article.
January 8, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29317253/cxcr4-antagonist-amd3100-enhances-the-response-of-mda-mb-231-triple-negative-breast-cancer-cells-to-ionizing-radiation
#2
K X Zhou, L H Xie, X P, Q M Guo, Q Y Wu, W H Wang, G L Zhang, J F Wu, G J Zhang, C W Du
Radiation therapy (RT) is one of the primary modalities for triple-negative breast cancer (TNBC) treatment. However, due to the pro-metastatic potential of radiation and the intrinsic radiation resistance of some tumors, many patients experience RT failure, which leads to cancer relapse and distant metastasis. This preclinical study evaluated the efficacy of the antagonist of the SDF-1 receptor CXCR4, AMD3100, as a radiosensitizer in TNBC models. The combined effect of ionizing radiation and AMD3100 was determined in vitro by surviving fraction, cell cycle distribution, Bax and Bcl-2 expression, and apoptosis assays in a TNBC cell line (MDA-MB-231)...
January 6, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29316680/effect-of-low-molecular-weight-oligopeptides-isolated-from-sea-cucumber-on-diabetic-wound-healing-in-db-db-mice
#3
Di Li, Lin Li, Teng Xu, Tianxing Wang, Jinwei Ren, Xinran Liu, Yong Li
Impaired wound healing is a major clinical problem in patients with diabetes and is the leading cause of lower limb amputation. This study is aimed to observe the effects of small molecule oligopeptides isolated from sea cucumber (SCCOPs) on the wound healing process in diabetic mice. Ninety db/db male mice were divided into five groups, including the model control group, whey protein group (0.50 g/kg) and three SCCOPs dose groups (0.25 g/kg, 0.50 g/kg and 1.00 g/kg). Additionally, 18 db/m male mice were used as normal control group...
January 8, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29312699/role-of-the-stromal-cell-derived-factor-1-cxc-chemokine-receptor-4-axis-in-the-invasion-and-metastasis-of-lung-cancer-and-mechanism
#4
Yun Zeng, Xinwei Wang, Bijian Yin, Guohao Xia, Zhengjie Shen, Wenzhe Gu, Mianhua Wu
Background: Lung cancer is the most common tumor, and has the highest incidence and mortality rates among all malignant tumors. Since stromal cell derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) are specific to binding sites, they are more important than other members of the families for tumor invasion and metastasis. We herein aimed to investigate the role of the axis of chemokine SDF-1 and its receptor CXCR4 in the invasion and metastasis of lung cancer. Methods: Sixty clinical non-small cell lung cancer (NSCLC) tissue samples were collected...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29311692/surface-functionalization-of-electrospun-scaffolds-using-recombinant-human-decorin-attracts-circulating-endothelial-progenitor-cells
#5
Svenja Hinderer, Katrin Sudrow, Maria Schneider, Monika Holeiter, Shannon Lee Layland, Martina Seifert, Katja Schenke-Layland
Decorin (DCN) is an important small leucine-rich proteoglycan present in the extracellular matrix (ECM) of many organs and tissues. Endothelial progenitor cells (EPCs) are able to interact with the surrounding ECM and bind to molecules such as DCN. Here, we recombinantly produced full-length human DCN under good laboratory practice (GLP) conditions, and after detailed immunological characterization, we investigated its potential to attract murine and human EPCs (mEPCs and hECFCs). Electrospun polymeric scaffolds were coated with DCN or stromal cell-derived factor-1 (SDF-1α) and were then dynamically cultured with both cell types...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310647/have-dipeptidyl-peptidase-4-inhibitors-ameliorated-the-vascular-complications-of-type-2-diabetes-in-large-scale-trials-the-potential-confounding-effect-of-stem-cell-chemokines
#6
REVIEW
Milton Packer
Drugs that inhibit dipeptidyl peptidase-4 (DPP-4) are conventionally regarded as incretin-based agents that signal through the glucagon-like peptide-1 (GLP-1) receptor. However, inhibition of DPP-4 also potentiates the stem cell chemokine, stromal cell-derived factor-1 (SDF-1), which can promote inflammation, proliferative responses and neovascularization. In large-scale cardiovascular outcome trials, enhanced GLP-1 signaling has reduced the risk of atherosclerotic ischemic events, potentially because GLP-1 retards the growth and increases the stability of atherosclerotic plaques...
January 8, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29299123/inhibition-of-sdf-1-induced-migration-of-oncogene-driven-myeloid-leukemia-by-the-l-rna-aptamer-spiegelmer-nox-a12-and-potentiation-of-tyrosine-kinase-inhibition
#7
Ellen L Weisberg, Martin Sattler, Abdel Kareem Azab, Dirk Eulberg, Anna Kruschinski, Paul W Manley, Richard Stone, James D Griffin
Resistance to targeted tyrosine kinase inhibitors (TKI) remains a challenge for the treatment of myeloid leukemias. Following treatment with TKIs, the bone marrow microenvironment has been found to harbor a small pool of surviving leukemic CD34+ progenitor cells. The long-term survival of these leukemic cells has been attributed, at least in part, to the protective effects of bone marrow stroma. We found that the NOX-A12 'Spiegelmer', an L-enantiomeric RNA oligonucleotide that inhibits SDF-1α, showed in vitro and in vivo activity against BCR-ABL- and FLT3-ITD-dependent leukemia cells...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29297738/periarteriolar-glioblastoma-stem-cell-niches-express-bone-marrow-hematopoietic-stem-cell-niche-proteins
#8
Vashendriya V V Hira, Jill R Wormer, Hala Kakar, Barbara Breznik, Britt van der Swaan, Renske Hulsbos, Wikky Tigchelaar, Zbynek Tonar, Mohammed Khurshed, Remco J Molenaar, Cornelis J F Van Noorden
In glioblastoma, a fraction of malignant cells consists of therapy-resistant glioblastoma stem cells (GSCs) residing in protective niches that recapitulate hematopoietic stem cell (HSC) niches in bone marrow. We have previously shown that HSC niche proteins stromal cell-derived factor-1α (SDF-1α), C-X-C chemokine receptor type 4 (CXCR4), osteopontin (OPN), and cathepsin K (CatK) are expressed in hypoxic GSC niches around arterioles in five human glioblastoma samples. In HSC niches, HSCs are retained by binding of SDF-1α and OPN to their receptors CXCR4 and CD44, respectively...
January 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29297467/expansion-of-a-cd26low-effector-th-subset-and-reduction-of-circulating-levels-of-scd26-in-stable-allergic-asthma-in-adults
#9
J J Nieto-Fontarigo, F J González-Barcala, M E San-José, M J Cruz, T Linares, M T Soto-Mera, L Valdés, M A García-González, L J Andrade-Bulos, P Arias, M Nogueira, F J Salgado
BACKGROUND AND OBJECTIVE: Asthma pathogenesis is dependent on the balance between regulatory and effector T cells, which display differential expression of CD25 and CD26. Therefore, alteration of circulating levels of sCD25 and sCD26 during allergic asthma could be conditioned by leukocyte phenotype changes. Objectives: To analyse CD25 and CD26 expression on T lymphocytes and their soluble derivatives (sCD25, sCD26) during stable phases of moderate-severe allergic asthma. METHODS: Cross-sectional study with two adult cohorts of allergic asthmatics...
January 3, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29296749/high-cd123-levels-enhance-proliferation-in-response-to-il-3-but-reduce-chemotaxis-by-downregulating-cxcr4-expression
#10
Nicole L Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J Sandow, Melanie K Pudney, Mara Dottore, Richard J D'Andrea, Angel F Lopez, Paul G Ekert, Hayley S Ramshaw
High expression of the α chain of the interleukin-3 receptor (IL-3Rα; CD123) is a hallmark of acute myeloid leukemia (AML) leukemic stem cells (LSCs). Elevated CD123 expression is part of the diagnostic immunophenotyping of myeloid leukemia, and higher expression is associated with poor prognosis. However, the biological basis of the poorer prognosis is unclear, and may include heightened IL-3 signaling and non-cell autonomous interactions with the bone marrow (BM) microenvironment. We used TF-1 cells expressing different levels of CD123 and found elevated CD123 levels amplified the proliferative response to exogenous IL-3 and maintained viability in reducing IL-3 concentrations...
June 27, 2017: Blood Advances
https://www.readbyqxmd.com/read/29289726/caries-arrest-by-topical-fluorides-in-preschool-children-30-month-results
#11
D Duangthip, M C M Wong, C H Chu, E C M Lo
OBJECTIVE: To compare the effectiveness of three applications of silver diammine fluoride (SDF) solution at yearly interval and three applications of SDF solution or sodium fluoride (NaF) varnish at weekly interval at baseline in arresting active caries in the primary teeth of preschool children. METHODS: Children aged 3-4 years (n = 371) who had at least one active caries lesion (ICDAS codes 3-6) in their primary teeth were randomly allocated into three groups: Group 1 - annual application of 30% SDF solution; Group 2 - three applications of 30% SDF at weekly intervals; and Group 3 - three applications of 5% NaF varnish at weekly intervals...
December 28, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29288743/the-good-and-bad-faces-of-the-cxcr4-chemokine-receptor
#12
REVIEW
Joaquin Teixidó, Mónica Martínez-Moreno, Marta Díaz-Martínez, Silvia Sevilla-Movilla
Chemokines are chemotactic cytokines that promote cell migration and activation under homeostatic and inflammatory conditions. Chemokines bind to seven transmembrane-spanning receptors that are coupled to heterotrimeric guanine nucleotide-binding (G) proteins, which are the responsible for intracellularly transmitting the activating signals for cell migration. Hematopoiesis, vascular development, lymphoid organ morphogenesis, cardiogenesis and neural differentiation are amongst the processes involving chemokine function...
December 27, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29287369/preparation-characterization-and-calcium-release-evaluation-in-vitro-of-casein-phosphopeptides-soluble-dietary-fibers-copolymers-as-calcium-delivery-system
#13
Ang Gao, Shuang Dong, Xu Wang, Shuhong Li, Ye Chen
Delivery systems based on food-grade biopolymers are of particular interest for food applications. Here, we introduce a new calcium delivery system with a high calcium-binding capacity and controlled calcium release. The system integrates casein phosphopeptides (CPP) with soluble dietary fibers (SDF). The physicochemical properties, calcium-binding capacities, controlled calcium release properties and formation mechanisms of the prepared copolymers with different mass ratios of CPP/SDF after thermal treatment were studied...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29285291/serum-sdf-1-levels-are-a-reliable-diagnostic-marker-of-feline-mammary-carcinoma-discriminating-her2-overexpressing-tumors-from-other-subtypes
#14
Cláudia S Marques, Maria Soares, Ana Santos, Jorge Correia, Fernando Ferreira
The feline mammary carcinoma (FMC) is the third most common tumor in cat, sharing many clinicopathological features with human breast cancer and thus, considered a suitable model for comparative oncology. Due to its poor prognosis, further studies are required to improve the diagnostic accuracy and treatment of cats with spontaneous mammary carcinoma. Recently, it was reported that the overexpression of stromal cell-derived factor-1 (SDF-1) has great value in human breast cancer diagnosis, suggesting that diagnostic tools and therapies targeting the SDF-1 ligand can improve the clinical outcome...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29284451/synovial-inflammation-plays-a-greater-role-in-post-traumatic-osteoarthritis-compared-to-idiopathic-osteoarthritis-in-the-hartley-guinea-pig-knee
#15
Nathan P Thomas, Wesley J Wu, Braden C Fleming, Fangyuan Wei, Qian Chen, Lei Wei
BACKGROUND: The objective of this study was to evaluate the extent of stromal cell-derived factor-1's (SDF-1) involvement in the pathogenesis of idiopathic versus post-traumatic OA by comparing differences in synovial membrane morphology, SDF-1 synovial fluid (SF) concentrations, and matrix metalloproteinase-13 (MMP-13) SF concentrations. METHODS: Thirty-six 3-month-old Hartley guinea pigs were obtained and divided into 6 groups. Upon sacrifice, India Ink staining was used to evaluate gross morphology, Safranin O/Fast green staining was used to assess cartilage damage, H/E staining was employed to visualize the synovium, and SF samples were obtained for biochemical analyses...
December 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29279118/in-situ-controlled-release-of-stromal-cell-derived-factor-1%C3%AE-and-antimir-138-for-on-demand-cranial-bone-regeneration
#16
Guangsheng Wu, Chao Feng, Jingjing Quan, Zhongshan Wang, Wei Wei, Shengqi Zang, Shuai Kang, Guangyan Hui, Xiguang Chen, Qintao Wang
Bone regeneration involves complex physiological processes, which is generally regulated and controlled by multiple bioactive molecules. In situ controlled release of combined bioactive factors in a spatiotemporal sequence for adapting the demand of bone regeneration is a desired strategy. In this study, nanoparticle/hydrogel composite system was constructed by incorporating stromal cell derived factor-1α (SDF-1α) and chitosan/tripolyphosphate/hyaluronic acid/antimiRNA-138 nanoparticles (CTH/antimiR-138 NPs) in chitosan/β-sodium glycerol phosphate (CS/GP) hydrogel for rat critical-size calvarial bone regeneration...
February 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29274477/intrafibrillar-silicified-collagen-scaffold-promotes-in-situ-bone-regeneration-by-activating-the-monocyte-p38-signaling-pathway
#17
Jin-Long Sun, Kai Jiao, Qun Song, Chu-Fan Ma, Chao Ma, Franklin R Tay, Li-Na Niu, Ji-Hua Chen
Intrafibrillar silicified collagen scaffold (SCS) is a promising biomaterial for bone regeneration because it promotes cell homing and angiogenesis in bone defects via monocyte modulation. In the present study, a rat femoral defect model was used to examine the contribution of monocyte signaling pathways to SCS modulation. Activation of the monocyte p38 signaling pathway by SCS resulted in monocyte differentiation into TRAP-positive mononuclear cells. These cells demonstrated increased secretion of SDF-1α, VEGFa and PDGF-BB, which, in turn, promoted homing of bone marrow stromal cells (BMSCs) and endothelial progenitor cells (EPCs), as well as local vascularization...
December 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29259394/characterizing-the-effect-of-supplements-on-the-phenotype-of-cultured-macrophages-from-patients-with-age-related-macular-degeneration
#18
Batya Rinsky, Shira Hagbi-Levi, Sarah Elbaz-Hayoun, Michelle Grunin, Itay Chowers
Purpose: Oral vitamin and mineral supplements reduce the risk of visual loss in age-related macular degeneration (AMD). However, the pathways that mediate this beneficial effect are poorly understood. Macrophages may exert oxidative, inflammatory, and angiogenic effects in the context of AMD. We aim to assess if oral supplements can modulate the macrophage phenotype in this disease. Methods: Monocytes were isolated from patients with neovascular AMD (nvAMD), cultured, matured to macrophages, and polarized to classical [M1 (stimulated by IFNγ and lipopolysaccharide (LPS))] and alternative [M2 (stimulated with IL-4 and IL-13)] phenotypes...
2017: Molecular Vision
https://www.readbyqxmd.com/read/29259281/effects-of-resistance-exercise-on-endothelial-progenitor-cell-mobilization-in-women
#19
Fernando Ribeiro, Ilda P Ribeiro, Ana C Gonçalves, Alberto J Alves, Elsa Melo, Raquel Fernandes, Rui Costa, Ana B Sarmento-Ribeiro, José A Duarte, Isabel M Carreira, Sarah Witkowski, José Oliveira
This study aimed to determine the effect of a single bout of resistance exercise at different intensities on the mobilization of circulating EPCs over 24 hours in women. In addition, the angiogenic factors stromal cell-derived factor 1 (SDF-1α), vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1α) and erythropoietin (EPO) were measured as potential mechanisms for exercise-induced EPCs mobilization. Thirty-eight women performed a resistance exercise session at an intensity of 60% (n = 13), 70% (n = 12) or 80% (n = 13) of one repetition maximum...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29258450/serum-cytokine-profiles-predict-survival-benefits-in-patients-with-advanced-hepatocellular-carcinoma-treated-with-sorafenib-a-retrospective-cohort-study
#20
Tomoyuki Hayashi, Taro Yamashita, Takeshi Terashima, Tsuyoshi Suda, Hikari Okada, Yoshiro Asahina, Takehiro Hayashi, Yasumasa Hara, Kouki Nio, Hajime Sunagozaka, Hajime Takatori, Kuniaki Arai, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko
BACKGROUND: Sorafenib is a multiple receptor tyrosine kinase inhibitor known to prolong overall survival in patients with advanced hepatocellular carcinoma (HCC). Predicting this drug's survival benefits is challenging because clinical responses are rarely measurable during treatment. In this study, we hypothesized that serum cytokines levels could predict the survival of advanced HCC patients, as sorafenib targets signaling pathways activated in the tumor stromal microenvironment and potentially affects serum cytokine profiles...
December 19, 2017: BMC Cancer
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