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https://www.readbyqxmd.com/read/28099928/the-sdf-1-cxcr4-axis-promotes-recovery-after-spinal-cord-injury-by-mediating-bone-marrow-derived-from-mesenchymal-stem-cells
#1
Guo-Dong Wang, Yi-Xun Liu, Xiao Wang, Yong-Le Zhang, Ya-Dong Zhang, Feng Xue
This study aims to explore the role of the SDF-1/CXCR4 axis in mediating BMSCs and SCI recovery. BMSCs were collected and SCI rat models were established. Wistar rats were assigned into the blank control, sham, SCI, SCI + BMSCs, SCI + BMSCs + SDF-1, SCI + BMSCs + AMD3100 (an inhibitor of SDF-1/CXCR4 axis) and SCI + BMSCs + SDF-1 + AMD3100 groups. Hind limb motor function was measured 7, 14, 21 and 28 days after operation. qRT-PCR, western blotting and ELISA was performed to determine the expressions of SDF-1, CXCR4, NGF, BDNF, GFAP and GAP-43, TNF-α, IL-1β, L-6 and IFN-γ...
January 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28099683/angiogenesis-mediators-in-women-with-idiopathic-heavy-menstrual-bleeding
#2
Osama A Elkilani, Mohamed A Soliman
OBJECTIVE: To assess the relationship between stromal cell-derived factor 1 (SDF-1) and mature endothelial cells in patients with heavy menstrual bleeding (HMB). METHODS: In a prospective observational study, women with idiopathic HMB and control individuals attending Menoufia University Hospital, Egypt, between August 2015 and January 2016 were enrolled. The inclusion criteria were a regular menstrual cycle, a normal coagulation study, and no anomalous ultrasonographic or hysteroscopic findings...
November 25, 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28078743/bivalent-14-mer-peptide-ligands-of-cxcr4-with-polyproline-linkers-with-anti-chemotactic-activity-against-jurkat-cells
#3
Tomohiro Tanaka, Toru Aoki, Wataru Nomura, Hirokazu Tamamura
Interaction of CXCR4 with its endogenous ligand, stromal-cell derived factor-1 (SDF-1)/CXCL12, induces various physiological functions involving chemotaxis. Bivalent ligands with a polyproline helix bearing a cyclic pentapeptide, FC131, were previously shown to have higher binding affinities for CXCR4 than the corresponding monovalent ligands. Bivalent ligands based on a 14-mer peptide T140 derivative with polyproline linkers have been designed and synthesized. The activity of these peptides as well as the effect of bivalency of the ligand on CXCR4 binding has been assessed...
January 12, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28078226/clinical-utility-of-sperm-dna-fragmentation-testing-practice-recommendations-based-on-clinical-scenarios
#4
REVIEW
Ashok Agarwal, Ahmad Majzoub, Sandro C Esteves, Edmund Ko, Ranjith Ramasamy, Armand Zini
Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for male fertility evaluation. While its detrimental implications on sperm function were extensively investigated, little is known about the actual indications for performing SDF analysis. This review delivers practice based recommendations on commonly encountered scenarios in the clinic. An illustrative description of the different SDF measurement techniques is presented. SDF testing is recommended in patients with clinical varicocele and borderline to normal semen parameters as it can better select varicocelectomy candidates...
December 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078186/soluble-receptor-for-advanced-glycation-end-products-improves-stromal-cell-derived-factor-1-activity-in-model-diabetic-environments
#5
Melissa Przyborowski Olekson, Renea A Faulknor, Henry C Hsia, Ann Marie Schmidt, François Berthiaume
Objective: In diabetes, hyperglycemia causes the accumulation of advanced glycation end products (AGEs) that trigger reactive oxygen species (ROS) generation through binding the receptor for AGEs (RAGE). Because exogenous growth factors have had little success in enhancing chronic wound healing, we investigated whether hyperglycemia-induced AGEs interfere with cellular responses to extracellular signals. We used stromal cell-derived factor-1 (SDF-1), an angiogenic chemokine also known to promote stem cell recruitment in skin wounds...
December 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/28075616/role-of-cxc-chemokine-receptor-type-4-as-a-lactoferrin-receptor
#6
Yoshiharu Takayama, Reiji Aoki, Ryo Uchida, Atsushi Tajima, Ayako Aoki-Yoshida
Lactoferrin exerts its biological activities by interacting with receptors on target cells, including LDL receptor-related protein-1 (LRP-1/CD91), intelectin-1 (omentin-1), and Toll-like receptor 4 (TLR4). However, the effects mediated by these receptors are not sufficient to fully explain the many functions of lactoferrin. C-X-C-motif cytokine receptor 4 (CXCR4) is a ubiquitously expressed G-protein coupled receptor for stromal cell-derived factor-1 (SDF-1/CXCL12). Lactoferrin was found to be as capable as SDF-1 in blocking infection by an HIV variant that uses CXCR4 as a co-receptor (X4-tropic HIV), suggesting that lactoferrin interacts with CXCR4...
October 31, 2016: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28074071/olaptesed-pegol-an-anti-cxcl12-sdf-1-spiegelmer-%C3%A2-alone-and-with-bortezomib-dexamethasone-in-relapsed-refractory-multiple-myeloma-a-phase-iia-study
#7
H Ludwig, K Weisel, M T Petrucci, X Leleu, A M Cafro, L Garderet, C Leitgeb, R Foa, R Greil, I Yakoub-Agha, D Zboralski, S Vauléon, T Dümmler, D Beyer, Ana Kruschinski, K Riecke, M Baumann, M Engelhardt
Leukemia accepted article preview online, 11 January 2017. doi:10.1038/leu.2017.5.
January 11, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28074045/high-expression-of-stromal-cell-derived-factor-1-sdf-1-and-nf-%C3%AE%C2%BAb-predicts-poor-prognosis-in-cervical-cancer
#8
Zhiwang Song, Xia Zhang, Xiaojuan Ye, Chan Feng, Guang Yang, Yonglin Lu, Yun Lin, Chunyan Dong
BACKGROUND SDF-1 and NF-κB are associated with the prognosis of a wide range of cancers, but their value in cervical cancer remains controversial. The aim of this study was to investigate the expression of SDF-1and NF-κB in cervical cancer and their significance in clinical prognosis. MATERIAL AND METHODS The expression of SDF-1and NF-κB in 105 formalin-fixed, paraffin-embedded cervical cancer tissues and the adjacent tissues was examined by immunohistochemistry (IHC). The results were semi-quantitatively scored and analyzed by chi-square test...
January 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28073175/post-reperfusion-microcirculatory-derangements-after-liver-transplantation-relationship-to-hemodynamics-serum-mediators-and-outcome
#9
Carlo Pulitano, David Joseph, Charbel Sandroussi, Deborah Verran, Phong Ho, Ashe Debiasio, Adriano Luongo, Geoffrey W McCaughan, Nicholas Shackel, Michael Crawford
INTRODUCTION: Despite the growing data supporting the role of microcirculation in regulating liver function, little of this knowledge has been translated into clinical practice. The aim of this study is to quantify hepatic microcirculation in-vivo using sidestream dark-field (SDF) imaging and correlate these finding with hepatic blood flow, hemodynamic parameters, and soluble mediators. METHODS: Post-reperfusion hepatic microcirculation was assessed using SDF imaging...
January 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28072855/sdf-1%C3%AE-cxcr4-signaling-in-lipid-rafts-induces-platelet-aggregation-via-pi3-kinase-dependent-akt-phosphorylation
#10
Hiroko Ohtsuka, Tomohiro Iguchi, Moyuru Hayashi, Mizuho Kaneda, Kazuko Iida, Motoyuki Shimonaka, Takahiko Hara, Morio Arai, Yuichi Koike, Naomasa Yamamoto, Kohji Kasahara
Stromal cell-derived factor-1α (SDF-1α)-induced platelet aggregation is mediated through its G protein-coupled receptor CXCR4 and phosphatidylinositol 3 kinase (PI3K). Here, we demonstrate that SDF-1α induces phosphorylation of Akt at Thr308 and Ser473 in human platelets. SDF-1α-induced platelet aggregation and Akt phosphorylation are inhibited by pretreatment with the CXCR4 antagonist AMD3100 or the PI3K inhibitor LY294002. SDF-1α also induces the phosphorylation of PDK1 at Ser241 (an upstream activator of Akt), GSK3β at Ser9 (a downstream substrate of Akt), and myosin light chain at Ser19 (a downstream element of the Akt signaling pathway)...
2017: PloS One
https://www.readbyqxmd.com/read/28067275/sdf-1-cxcr4-axis-induces-human-dental-pulp-stem-cell-migration-through-fak-pi3k-akt-and-gsk3%C3%AE-%C3%AE-catenin-pathways
#11
Mingwei Li, Xuefei Sun, Liang Ma, Lu Jin, Wenfei Zhang, Min Xiao, Qing Yu
SDF-1 (stromal cell derived factor-1) has been found to be widely expressed during dental pulp inflammation, while hDPSCs (human dental pulp stem cells) contribute to the repair of dental pulp. We showed that the migration of hDPSCs was induced by SDF-1 in a concentration-dependent manner and could be inhibited with siCXCR4 (C-X-C chemokine receptor type 4) and siCDC42 (cell division control protein 42), as well as drug inhibitors such as AMD3100 (antagonist of CXCR4), LY294002 (inhibitor of PI3K) and PF573228 (inhibitor of FAK)...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28060837/beneficial-effects-of-reconstituted-high-density-lipoprotein-rhdl-on-circulating-cd34-cells-in-patients-after-an-acute-coronary-syndrome
#12
Catherine Gebhard, Eric Rhéaume, Colin Berry, Geneviève Brand, Anne-Elen Kernaleguen, Gabriel Théberge-Julien, Mohammad Afaque Alam, Candace Y W Lee, Laurianne Boileau, Malorie Chabot-Blanchet, Marie-Claude Guertin, Marc-André Lavoie, Jean Grégoire, Réda Ibrahim, Philippe L'Allier, Jean-Claude Tardif
BACKGROUND: High-density lipoproteins (HDL) favorably affect endothelial progenitor cells (EPC). Circulating progenitor cell level and function are impaired in patients with acute coronary syndrome (ACS). This study investigates the short-term effects of reconstituted HDL (rHDL) on circulating progenitor cells in patients with ACS. METHODS AND FINDINGS: The study population consisted of 33 patients with recent ACS: 20 patients from the ERASE trial (randomized to receive 4 weekly intravenous infusions of CSL-111 40 mg/kg or placebo) and 13 additional patients recruited as controls using the same enrolment criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28057017/the-brain-penetrating-cxcr4-antagonist-prx177561-increases-the-antitumor-effects-of-bevacizumab-and-sunitinib-in-preclinical-models-of-human-glioblastoma
#13
Giovanni Luca Gravina, Andrea Mancini, Francesco Marampon, Alessandro Colapietro, Simona Delle Monache, Roberta Sferra, Flora Vitale, Peter J Richardson, Lee Patient, Stephen Burbidge, Claudio Festuccia
BACKGROUND: Glioblastoma recurrence after treatment with the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab is characterized by a highly infiltrative and malignant behavior that renders surgical excision and chemotherapy ineffective. It has been demonstrated that anti-VEGF/VEGFR therapies control the invasive phenotype and that relapse occurs through the increased activity of CXCR4. We therefore hypothesized that combining bevacizumab or sunitinib with the novel CXCR4 antagonist, PRX177561, would have superior antitumor activity...
January 5, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28056602/the-potential-of-stromal-cell-derived-factor-1-delivery-using-a-collagen-membrane-for-bone-regeneration
#14
Tadahiro Takayama, Jisen Dai, Keita Tachi, Ryutaro Shohara, Hironori Kasai, Kentaro Imamura, Seiichi Yamano
Stromal cell-derived factor-1 (SDF-1) is a cytokine that is important in stem and progenitor cell recruitment in tissue repair after injury. Regenerative procedures using collagen membranes (CMs) are presently well established in periodontal and implant dentistry. The objective of this study is to test the subsequent effects of the released SDF-1 from a CM on bone regeneration compared to platelet-derived growth factor (PDGF) in vitro and in vivo. For in vitro studies, cell proliferation, alkaline phosphatase activity, and osteoblastic differentiation marker genes were assessed after MC3T3-E1 mouse preosteoblasts were cultured with CMs containing factors...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28053103/cytokines-elevated-in-hiv-elite-controllers-reduce-hiv-replication-in-vitro-and-modulate-hiv-restriction-factor-expression
#15
Evan S Jacobs, Sheila M Keating, Mohamed Abdel-Mohsen, Stuart L Gibb, John W Heitman, Heather C Inglis, Jeffrey N Martin, Jinbing Zhang, Zhanna Kaidarova, Xutao Deng, Shiquan Wu, Kathryn Anastos, Howard Crystal, Maria C Villacres, Mary Young, Ruth M Greenblatt, Alan L Landay, Stephen J Gange, Steven G Deeks, Elizabeth T Golub, Satish K Pillai, Philip J Norris
: A subset of HIV infected individuals termed elite controllers (ECs) maintain CD4+ T cell counts and control viral replication in the absence of antiretroviral therapy (ART). Systemic cytokine responses may differentiate ECs from subjects with uncontrolled viral replication or those who require ART to suppress viral replication. We measured 87 cytokines in four groups of women: 73 EC, 42 with pharmacologically suppressed viremia (ART), 42 with uncontrolled viral replication (noncontrollers, NC), and 48 HIV uninfected (NEG) subjects...
January 4, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28045930/the-ccl2-ccr2-axis-affects-transmigration-and-proliferation-but-not-resistance-to-chemotherapy-of-acute-myeloid-leukemia-cells
#16
Patricia Macanas-Pirard, Thomas Quezada, Leonardo Navarrete, Richard Broekhuizen, Andrea Leisewitz, Bruno Nervi, Pablo A Ramírez
Acute myeloid leukemia (AML) has a high mortality rate despite chemotherapy and transplantation. Both CXCR4/SDF-1 and VLA-4/VCAM1 axes are involved in leukemia protection but little is known about the role of CCL2/CCR2 in AML biology and protection against chemotherapy. We measured CCR2 expression in AML cell lines and primary AML cells by flow cytometry (FCM), real time PCR (RT-PCR) and western blot (WB). CCL2 production was quantified by solid phase ELISA in peripheral blood (PB) and bone marrow (BM) serum...
2017: PloS One
https://www.readbyqxmd.com/read/28040478/cathepsin-k-cleavage-of-sdf-1%C3%AE-inhibits-its-chemotactic-activity-towards-glioblastoma-stem-like-cells
#17
Vashendriya V V Hira, Urška Verbovšek, Barbara Breznik, Matic Srdič, Marko Novinec, Hala Kakar, Jill Wormer, Britt Van der Swaan, Brigita Lenarčič, Luiz Juliano, Shwetal Mehta, Cornelis J F Van Noorden, Tamara T Lah
Glioblastoma (GBM) is the most aggressive primary brain tumor with poor patient survival that is at least partly caused by malignant and therapy-resistant glioma stem-like cells (GSLCs) that are protected in GSLC niches. Previously, we have shown that the chemo-attractant stromal-derived factor-1α (SDF-1α), its C-X-C receptor type 4 (CXCR4) and the cysteine protease cathepsin K (CatK) are localized in GSLC niches in glioblastoma. Here, we investigated whether SDF-1α is a niche factor that through its interactions with CXCR4 and/or its second receptor CXCR7 on GSLCs facilitates their homing to niches...
December 28, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28038429/amd3100-combined-with-triptolide-inhibit-proliferation-invasion-and-metastasis-and-induce-apoptosis-of-human-u2os-osteosarcoma-cells
#18
Chunming Jiang, Xiang Fang, Hongxu Zhang, Xuepeng Wang, Maoqiang Li, Wu Jiang, Fei Tian, Liulong Zhu, Zhenyu Bian
BACKGROUND: Osteosarcoma (OS) mainly occurs in children and adolescents, and has a high propensity for lung metastasis. Little is known about the role of SDF-1/CXCR4 axis in OS progression. AMD3100 is a specific CXCR4 antagonist. Triptolide can induce apoptosis and proliferation inhibition in various cancer cell lines. OBJECTIVE: This work aimed to investigate the effects of AMD3100 plus triptolide on the proliferation, apoptosis, invasion and metastasis of OS cells...
December 27, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28035356/effect-of-yi-guan-jian-decoction-on-differentiation-of-bone-marrow-mesenchymalstem-cells-into-hepatocyte-like-cells-in-dimethylnitrosamine-induced-liver-cirrhosis-in-mice
#19
Yan Xiang, Bing-Yao Pang, Yuan Zhang, Qiao-Ling Xie, Ying Zhu, Ai-Jing Leng, Long-Qing Lu, Hai-Long Chen
Yi Guan Jian decoction (YGD) may induce the differentiation of bone marrow mesenchymal stem cells (BMSCs) into hepatocyte-like cells (HLCs); however, the underlying mechanisms remain to be elucidated. The present study aimed to investigate this process. To do this, a dimethylnitrosamine (DMN)-induced liver cirrhosis mouse model was established. The mice from the model group were randomly divided into three subgroups: i) Negative control, ii) hepatocyte growth factor and iii) YGD. The overall health, liver function and histological alterations were monitored...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28032520/differential-expression-of-sdf-1-receptor-cxcr4-in-molecularly-defined-forms-of-inherited-thrombocytopenias
#20
Juan P Salim, Ana C Glembotsky, Paola R Lev, Cecilia P Marin Oyarzún, Nora P Goette, Felisa C Molinas, Rosana F Marta, Paula G Heller
The SDF-1-CXCR4 axis plays an essential role in the regulation of platelet production, by directing megakaryocyte (MK) migration toward the vascular niche, thus allowing terminal maturation and proplatelet formation, and also regulates platelet function in an autocrine manner. Inherited thrombocytopenias (IT) comprise a spectrum of diverse clinical conditions caused by mutations in genes involved in platelet production and function. We assessed CXCR4 expression and SDF-1 levels in a panel of well-characterized forms of IT...
December 29, 2016: Platelets
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