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https://www.readbyqxmd.com/read/28797111/angiogenic-t-cell-expansion-correlates-with-severity-of-peripheral-vascular-damage-in-systemic-sclerosis
#1
Mirko Manetti, Sara Pratesi, Eloisa Romano, Silvia Bellando-Randone, Irene Rosa, Serena Guiducci, Bianca Saveria Fioretto, Lidia Ibba-Manneschi, Enrico Maggi, Marco Matucci-Cerinic
The mechanisms underlying endothelial cell injury and defective vascular repair in systemic sclerosis (SSc) remain unclear. Since the recently discovered angiogenic T cells (Tang) may have an important role in the repair of damaged endothelium, this study aimed to analyze the Tang population in relation to disease-related peripheral vascular features in SSc patients. Tang (CD3+CD31+CXCR4+) were quantified by flow cytometry in peripheral blood samples from 39 SSc patients and 18 healthy controls (HC). Circulating levels of the CXCR4 ligand stromal cell-derived factor (SDF)-1α and proangiogenic factors were assessed in paired serum samples by immunoassay...
2017: PloS One
https://www.readbyqxmd.com/read/28791359/stromal-cell-derived-factor-1-protects-human-periodontal-ligament-stem-cells-against-hydrogen-peroxide-induced-apoptosis
#2
Yimiao Feng, Xiaohui Fu, Xintian Lou, Baiping Fu
Periodontal ligament stem cells (PDLSCs) are considered a promising cell source for dental tissue regeneration. Stromal cell-derived factor 1 [SDF‑1, also known as chemokine (C‑X‑C motif) ligand 12] is regarded as a critical cytokine involved in stem/progenitor cell chemotaxis and homing during tissue regeneration. The present study described a previously unsuspected role for SDF‑1 in the protection of PDLSCs against oxidative stress‑induced apoptosis. In the present study, apoptosis was induced by exposure of PDLSCs to various concentrations of H2O2 for 12 h, following which cell viability was assessed, and cleaved caspase‑3 and ‑9 expression levels were evaluated...
August 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28783870/cxcr4-antagonist-delivery-on-decellularized-skin-scaffold-facilitates-impaired-wound-healing-in-diabetic-mice-by-increasing-expression-of-sdf-1-and-enhancing-migration-of-cxcr4-positive-cells
#3
Hao Liu, Hanping Liu, Xiaoyuan Deng, Maosheng Chen, Xue Han, Wenxia Yan, Ning Wang
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal cell-derived factor 1 (SDF-1 also called CXCL12). The antagonist of CXCR4 can mobilize CD34+ cells and hematopoietic stem cells from bone marrow within several hours, and it has an efficacy on diabetes ulcer through acting on the SDF-1/CXCR4 axis. In this study, we investigated for the first time whether the antagonist of CXCR4 (Plerixafor/AMD3100) delivered on acellular dermal matrix (ADM) may accelerate diabetes-impaired wound healing...
June 8, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28780431/thermosensitive-chitosan-based-hydrogels-releasing-stromal-cell-derived-factor-1-alpha-recruit-msc-for-corneal-epithelium-regeneration
#4
Qiaomei Tang, Chenqi Luo, Bing Lu, Qiuli Fu, Houfa Yin, Zhenwei Qin, Danni Lyu, Lifang Zhang, Zhi Fang, Yanan Zhu, Ke Yao
Corneal epithelium integrity depends on continuous self-renewing of epithelium and connections between adjacent cells or between the cells and the basement membrane. Self-renewing epithelium cells mainly arise from the continuous proliferation and differentiation of the basal layer and limbal stem cells. The aim of the present study was to generate a bioactive, thermosensitive chitosan-gelatin hydrogel (CHI hydrogel) by incorporating exogenous recombinant human stromal cell-derived factor-1 alpha (SDF-1 alpha) for corneal epithelium regeneration...
August 2, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28774332/baicalin-attenuates-chronic-hypoxia-induced-pulmonary-hypertension-via-adenosine-a2a-receptor-induced-sdf-1-cxcr4-pi3k-akt-signaling
#5
Xiaoying Huang, Peiliang Wu, Feifei Huang, Min Xu, Mayun Chen, Kate Huang, Guo-Ping Li, Manhuan Xu, Dan Yao, Liangxing Wang
BACKGROUND: Baicalin, an important flavonoid in Scutellaria baicalensis Georgi extracts, exerts a variety of pharmacological effects. In this study, we explored the effects of baicalin on chronic hypoxia-induced pulmonary arterial hypertension (PAH) and investigated the mechanism underlying these effects. Moreover, we examined whether the inflammatory response was mediated by the A2A receptor (A2AR) and stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4)-induced phosphatidyl inositol-3-kinase (PI3K) signaling in vivo...
August 3, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28765024/amd3100-accelerates-reendothelialization-of-neointima-in-rabbit-saccular-aneurysm-after-flow-diverter-treatment
#6
Zifu Li, Rui Zhao, Xinggen Fang, Jiahao Zhou, Guoquan Jiang, Qinghai Huang, Jianmin Liu
OBJECTIVE: To inspect the role of AMD3100 that acts as an antagonist of SDF-1/CXCR4 on the formation of neointima in rabbit saccular aneurysm after flow diverter (FD) treatment. METHODS: Twenty saccular aneurysm models were established by using porcine pancreatic elastase. Three weeks later, a FDs of Tubridge was implanted into the saccular aneurysm. All treated models were immediately divided into two groups: the AMD3100 group was subcutaneously injected with AMD3100 (5 mg/kg per day), while control group with saline...
July 29, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28764573/human-periodontal-ligament-stem-cells-secretome-from-multiple-sclerosis-patients-suppresses-nalp3-inflammasome-activation-in-experimental-autoimmune-encephalomyelitis
#7
Thangavelu Soundara Rajan, Sabrina Giacoppo, Francesca Diomede, Placido Bramanti, Oriana Trubiani, Emanuela Mazzon
Research in recent years has largely explored the immunomodulatory effects of mesenchymal stem cells (MSCs) and their secretory products, called "secretome," in the treatment of neuroinflammatory diseases. Here, we examined whether such immunosuppressive effects might be elicited due to inflammasome inactivation. To this end, we treated experimental autoimmune encephalomyelitis (EAE) mice model of multiple sclerosis (MS) with the conditioned medium or purified exosomes/microvesicles (EMVs) obtained from relapsing-remitting-MS patients human periodontal ligament stem cells (hPDLSCs) and investigated the regulation of NALP3 inflammasome...
August 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28763008/omega-3-fatty-acids-supplementation-differentially-modulates-the-sdf-1-cxcr-4-cell-homing-axis-in-hypertensive-and-normotensive-rats
#8
Luiza Halmenschlager, Alexandre Machado Lehnen, Aline Marcadenti, Melissa Medeiros Markoski
BACKGROUND: We assessed the effect of acute and chronic dietary supplementation of ω-3 on lipid metabolism and cardiac regeneration, through its influence on the Stromal Derived Factor-1 (SDF-1) and its receptor (CXCR4) axis in normotensive and hypertensive rats. METHODS: Male Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were allocated in eight groups (of eight animals each), which received daily orogastric administration of ω-3 (1 g) for 24 h, 72 h or 2 weeks...
August 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28760975/concurrent-design-of-quasi-random-photonic-nanostructures
#9
Won-Kyu Lee, Shuangcheng Yu, Clifford J Engel, Thaddeus Reese, Dongjoon Rhee, Wei Chen, Teri W Odom
Nanostructured surfaces with quasi-random geometries can manipulate light over broadband wavelengths and wide ranges of angles. Optimization and realization of stochastic patterns have typically relied on serial, direct-write fabrication methods combined with real-space design. However, this approach is not suitable for customizable features or scalable nanomanufacturing. Moreover, trial-and-error processing cannot guarantee fabrication feasibility because processing-structure relations are not included in conventional designs...
July 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28754873/mifepristone-inhibits-ovarian-cancer-metastasis-by-intervening-in-sdf-1-cxcr4-chemokine-axis
#10
Ning Zheng, Jiahang Chen, Weiqun Liu, Jian Liu, Tao Li, Hongning Chen, Jichuang Wang, Lee Jia
SDF-1/CXCR4 signaling axis determines the proliferative potential and site-specific cancer metastasis. Recent studies suggest involvement of the axis and steroidal hormone in ovarian cancer metastasis. Here we hypothesize that mifepristone (RU486), a well-known progesterone-based abortifacient, might interfere this axis and inhibit ovarian cancer metastasis. Mifepristone at concentrations < IC50 inhibited expression of CXCR4 on cell surface of ovarian cancer SKOV-3 and IGROV-1, and reduced expression of the intracellular CXCR4 protein and its related mRNA activated by SDF-1...
July 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28754849/low-dose-photon-irradiation-induces-invasiveness-through-the-sdf-1%C3%AE-cxcr4-pathway-in-malignant-mesothelioma-cells
#11
Yoshikane Yamauchi, Seyer Safi, Lena Orschiedt, Adriane Gardyan, Stephan Brons, Juliane Rieber, Nils H Nicolay, Peter E Huber, Martin Eichhorn, Hendrik Dienemann, Felix J F Herth, Klaus-Josef Weber, Jürgen Debus, Hans Hoffmann, Stefan Rieken
BACKGROUND: Low-dose photon irradiation has repeatedly been suspected to increase a risk of promoting local recurrence of disease or even systemic dissemination. The purpose of this study was to investigate the motility of malignant pleural mesothelioma (MPM) cell lines after low-doses of photon irradiation and to elucidate the mechanism of the detected phenotype. METHODS: H28 and H226 MPM cells were examined in clonogenic survival experiments and migration assays with and without various doses of photon and carbon ion irradiation...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28753202/targeting-the-cxcr4-cxcl12-axis-in-treating-epithelial-ovarian-cancer
#12
T L Mao, K F Fan, C L Liu
Ovarian carcinoma is the most crucial and difficult target for available therapeutic treatments among gynecological malignancies, and great efforts are required to find an effective solution. Molecular studies showed that the chemokine stromal cell-derived factor (SDF)-1 (also known as CXCL12) and its receptor, CXCR4, are key determinants of tumor initiation, progression, and metastasis in ovarian carcinomas. Hence, it is generally believed that blocking the CXCR4/CXCL12 pathway could serve as a potential therapy for patients with ovarian cancer...
July 28, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28749529/effect-and-acceptance-of-silver-diamine-fluoride-treatment-on-dental-caries-in-primary-teeth
#13
Jennifer Clemens, Jaana Gold, Jeffrey Chaffin
OBJECTIVES: Silver diamine fluoride (SDF) treatment has been identified as a potential solution to address the dental public health issues of untreated dental caries and insufficient access to care. The current study assessed the effectiveness of 38 percent SDF in arresting active dental caries lesions and in reducing or preventing associated dental pain and infections in young, at-risk children. METHODS: We enrolled 32 children aged 2-5 years with 118 active caries lesions in primary teeth from a community dental clinic in Oregon...
July 27, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28747063/dpp4-inhibitors-can-be-a-drug-of-choice-for-type-3-diabetes-a-mini-review
#14
Nehru Sai Suresh Chalichem, Chaitanya Gonugunta, Praveen Thaggikuppe Krishnamurthy, Basavan Duraiswamy
As well known to the scientific community, Alzheimer's disease (AD) is an irreversible neurodegenerative disease that ends up with impairment of memory and cognition due to neuronal and synapse loss. Patient's quality of life can be enhanced by targeting neurogenesis as a therapeutic paradigm. Moreover, several research evidences support the concept that AD is a type of metabolic disorder mediated by impairment in brain insulin responsiveness and energy metabolism. Growing evidence suggests that endogenous peptides such as glucagon-like peptide-1 (GLP-1) and stromal-derived factor-1α (SDF-1α) provide neuroprotection across a range of experimental models of AD...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28745789/culture-conditions-of-human-embryonic-stem-cells-for-differentiation-into-retinal-vascular-structure
#15
Y-Z Pan, H Wang, F Gao
OBJECTIVE: This study sought to identify the suitable cell culture conditions for the in vitro-induced differentiation of human embryonic stem cells (hESCs) into retinal vascular tissue cell types. MATERIALS AND METHODS: To do this, we established four treatment groups. Group A was designed to culture hESCs in a three-dimensional system. The feeder cells and leukemia inhibitory factor (LIF) were removed in Group B. In group C, hESCs were cultured with a variety of pro-angiogenic growth factors...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28740450/single-nucleotide-polymorphisms-in-genes-macc1-rad18-mmp7-and-sdf-1a-as-prognostic-factors-in-resectable-colorectal-cancer
#16
Matej Horvat, Uros Potocnik, Katja Repnik, Rajko Kavalar, Vesna Zadnik, Stojan Potrc, Borut Stabuc
BACKGROUND: Colorectal cancer (CRC) represents one of the most common malignancies worldwide. Research has indicated that functional gene changes such as single nucleotide polymorphism (SNP) influence carcinogenesis and metastasis and might have an influence on disease relapse. The aim of our study was to evaluate the role of SNPs in selected genes as prognostic markers in resectable CRC. PATIENTS AND METHODS: In total, 163 consecutive patients treated surgically for CRC of stages I, II and III at the University Medical Centre in Maribor in 2007 and 2008 were investigated...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28740311/antimicrobial-resistance-and-typing-of-salmonella-isolated-from-street-vended-foods-and-associated-environment
#17
Anukampa, Bi Shagufta, M Sivakumar, Surender Kumar, Rajesh Kumar Agarwal, Kiran Narayan Bhilegaonkar, Ashok Kumar, Zunjar Baburao Dubal
The present study was carried out to find out the occurrence and types of Salmonella present in street vended foods and associated environment, and their resistance pattern against various antibiotics. About 1075 street vended food and associated environment samples were processed for isolation and confirmation of different Salmonella spp. by targeting gene specific invA gene and serotype specific Sdf I, Via B and Spy genes by PCR. Selected Salmonella isolates were screened for antibiotic resistance by using Baeur-Kirby disk diffusion test...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28739729/the-axis-of-cxcr4-sdf-1-plays-a-role-in-colon-cancer-cell-adhesion-through-regulation-of-the-akt-and-igf1r-signalling-pathways
#18
Fei Zheng, Zhongtao Zhang, Valentina Flamini, Wen G Jiang, Yuxin Cui
BACKGROUND/AIM: Colorectal cancer (CRC) is the third most common cancer in the world. The high mortality of this tumor is mainly due to its invasive properties, as it forms metastases in multiple organs, preferentially in the liver. There has evidence showing that C-X-C chemokine receptor type 4 (CXCR-4) and its ligand, stromal cell-derived factor-1 (SDF-1), plays an important role in cancer progression and metastasis. However, the molecular mechanism underling the CRCR4-mediated CRC metastasis has not been well characterized...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739546/in-situ-tissue-regeneration-through-sdf-1%C3%AE-driven-cell-recruitment-and-stiffness-mediated-bone-regeneration-in-a-critical-sized-segmental-femoral-defect
#19
Amaia Cipitria, Kathrin Boettcher, Sophia Schoenhals, Daniela S Garske, Katharina Schmidt-Bleek, Agnes Ellinghaus, Anke Dienelt, Anja Peters, Manav Mehta, Christopher M Madl, Nathaniel Huebsch, David J Mooney, Georg N Duda
In-situ tissue regeneration aims to utilize the body's endogenous healing capacity through the recruitment of host stem or progenitor cells to an injury site. Stromal cell-derived factor-1 α (SDF-1 α) is widely discussed as a potent chemoattractant. Here we use a cell-free biomaterial-based approach to (i) deliver SDF-1 α for the recruitment of endogenous bone marrow-derived stromal cells (BMSC) into a critical-sized segmental femoral defect in rats and to (ii) induce hydrogel stiffness-mediated osteogenic differentiation in-vivo...
July 21, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28734802/co-transplantation-of-mesenchymal-and-neural-stem-cells-and-overexpressing-stromal-derived-factor-1-for-treating-spinal-cord-injury
#20
Andrew N Stewart, Griffin Kendziorski, Zachary M Deak, Dara J Brown, Matthew N Fini, Katherine L Copely, Julien Rossignol, Gary L Dunbar
Genetic engineering of mesenchymal stem cells (MSCs) and neuronal stem cells (NSCs) has been used to treat spinal cord injuries (SCI). As a mechanism of therapy, MSCs secrete high amounts of anti-inflammatory cytokines and trophic factors, while NSCs can differentiate into neuronal lineages and aid in tissue replacement. Additionally, the forced overexpression of secreted proteins can enhance the secretome of transplanted cells, which can increase therapeutic efficacy. This study utilized a combinational treatment consisting of MSCs, NSCs, and the forced overexpression of the chemokine stromal-derived factor-1 (SDF-1) from MSCs (SDF-1-MSCs), to treat a rat model of SCI...
July 19, 2017: Brain Research
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