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https://www.readbyqxmd.com/read/28823142/oncogenes-mitochondrial-metabolism-and-quality-control-in-differentiated-thyroid-cancer
#1
Hyon-Seung Yi, Joon Young Chang, Koon Soon Kim, Minho Shong
Thyroid cancer is one of the most common malignancies of endocrine organs, and its incidence rate has increased steadily over the past several decades. Most differentiated thyroid tumors derived from thyroid epithelial cells exhibit slow-growing cancers, and patients with these tumors can achieve a good prognosis with surgical removal and radioiodine treatment. However, a small proportion of patients present with advanced thyroid cancer and are unusually resistant to current drug treatment modalities. Thyroid tumorigenesis is a complex process that is regulated by the activation of oncogenes, inactivation of tumor suppressors, and alterations in programmed cell death...
August 22, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28823064/preoperative-hypoalbuminemia-is-an-independent-risk-factor-for-increased-high-grade-morbidity-after-elective-rectal-cancer-resection
#2
J Hardt, L Pilz, J Magdeburg, P Kienle, S Post, R Magdeburg
PURPOSE: This study investigated the association of preoperative hypoalbuminemia and postoperative complications after elective resection for rectal cancer. METHODS: From September 2009 to December 2014, all patients who underwent elective rectal resection for adenocarcinoma of the rectum were identified using a prospective colorectal cancer database. Hypoalbuminemia was defined as a serum albumin < 35 g/L. Characteristics and outcomes of hypoalbuminemic patients were compared to those of patients with normal albumin levels...
August 19, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28823057/fusobacterium-nucleatum-as-a-prognostic-marker-of-colorectal-cancer-in-a-japanese-population
#3
Yuko Yamaoka, Yutaka Suehiro, Shinichi Hashimoto, Tomomi Hoshida, Michiyo Fujimoto, Michiya Watanabe, Daiki Imanaga, Kouhei Sakai, Toshihiko Matsumoto, Mitsuaki Nishioka, Taro Takami, Nobuaki Suzuki, Shoichi Hazama, Hiroaki Nagano, Isao Sakaida, Takahiro Yamasaki
BACKGROUND: Accumulating evidence shows an overabundance of Fusobacterium nucleatum in colorectal tumor tissues. However, the correlation between the absolute copy number of F. nucleatum in colorectal cancer tissues and colorectal cancer progression is unclear from previous reports. Therefore, we performed a study to compare the abundance of F. nucleatum in colorectal tissues with clinicopathologic and molecular features of colorectal cancer. METHODS: We collected 100 colorectal cancer tissues and 72 matched normal-appearing mucosal tissues...
August 19, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28823056/exploiting-non-canonical-translation-to-identify-new-targets-for-t-cell-based-cancer-immunotherapy
#4
REVIEW
Céline M Laumont, Claude Perreault
Cryptic MHC I-associated peptides (MAPs) are produced via two mechanisms: translation of protein-coding genes in non-canonical reading frames and translation of allegedly non-coding sequences. In general, cryptic MAPs are coded by relatively short open reading frames whose translation can be regulated at the level of initiation, elongation or termination. In contrast to conventional MAPs, the processing of cryptic MAPs is frequently proteasome independent. The existence of cryptic MAPs derived from allegedly non-coding regions enlarges the scope of CD8 T cell immunosurveillance from a mere ~2% to as much as ~75% of the human genome...
August 19, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28822844/a-ph-sensitive-methenamine-mandelate-loaded-nanoparticle-induces-dna-damage-and-apoptosis-of-cancer-cells
#5
Linhua Zhang, Wenbo Hao, Lv Xu, Yongfeng Gao, Xusheng Wang, Dunwan Zhu, Zhuo Chen, Xudong Zhang, Hongbo Chen, Lin Mei
Methenamine mandelate is a urinary antibacterial agent, which can be converted to formaldehyde in urine that has a relatively low pH of average 5.5-6.8. Here, we prepare a pH-sensitive PLGA-based nanoparticle containing both methenamine mandelate and NaHCO3. Methenamine mandelate/NaHCO3-coloaded nanoparticle could enter cells via endosome/lysosome pathway. The pH in lysosomes and endo-lysosomes is approximately 5.0. In the acidic environment, NaHCO3 reacts with proton and produce CO2 bubbles, which burst nanoparticles and lead to the rapidly release of methenamine mandelate...
August 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28822802/stromal-expression-of-activated-leukocyte-cell-adhesion-molecule-alcam-promotes-lung-tumor-growth-and-metastasis
#6
Ann-Helen Willrodt, Michal Beffinger, Martina Vranova, Darya Protsyuk, Katja Schuler, Maria Jadhav, Mathias Heikenwalder, Maries van den Broek, Lubor Borsig, Cornelia Halin Winter
Activated leukocyte cell adhesion molecule (ALCAM) is expressed on various cell types, including leukocytes, endothelial cells and certain tumor cells. While ALCAM expression on tumor cells has been linked with tumor invasion and metastatic spread, the contribution of ALCAM expressed in cells forming the tumor stroma to cancer progression has not been investigated. In this study, we made use of ALCAM-deficient (ALCAM(-/-)) mice to evaluate the role of ALCAM in lung tumor growth and metastasis. ALCAM(-/-) mice displayed an altered blood vascular network in the lung and the diaphragm, indicative of an angiogenesis defect...
August 16, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28822757/quercetin-exerts-synergetic-anti-cancer-activity-with-10-hydroxy-camptothecin
#7
Qin Tang, Fangling Ji, Jingyun Wang, Lianying Guo, Yachen Li, Yongming Bao
Quercetin (Qu) is known as a dietary antioxidant with numerous bioactivities, but its function in anti-cancer has not been fully investigated. Here, we show that Qu at low doses (≤10μM) significantly enhances the inhibition of 10-hydroxy camptothecin (HCPT) on the proliferation of MCF7, BGC823 and HepG2 cells. A plasmid DNA relaxation assay indicates that the inhibition of HCPT on the catalytic activity of topoisomerase I (Topo I) is increased by Qu at 10μM. Compared to the treatment by Qu or HCPT alone, phosphorylation at Ser(139) of γH2A...
August 16, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28822718/role-of-the-coagulation-system-in-genitourinary-cancers-review
#8
REVIEW
Axel John, Christian Gorzelanny, Alexander T Bauer, Stefan W Schneider, Christian Bolenz
Tumor progression is associated with aberrant hemostasis, and patients with malignant diseases have an elevated risk of developing thrombosis. A crosstalk among the vascular endothelium, components of the coagulation cascade, and cancer cells transforms the intravascular milieu to a prothrombotic, proinflammatory, and cell-adhesive state. We review the existing evidence on activation of the coagulation system and its implication in genitourinary malignancies and discuss the potential therapeutic benefit of antithrombotic agents...
July 26, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28822593/decreased-expression-of-microrna-122-is-associated-with-an-unfavorable-prognosis-in-childhood-acute-myeloid-leukemia-and-function-analysis-indicates-a-therapeutic-potential
#9
Juan Yang, Yufang Yuan, Xiaochun Yang, Ze Hong, Lijuan Yang
MicroRNA (miR)-122 functions as a tumor suppressor in various human cancers. However, its involvement in childhood acute myeloid leukemia (AML) remains unknown. In this study, quantitative real-time PCR assay demonstrated that miR-122 expression in bone marrow specimens from AML children were significantly lower than that in non-malignant controls (P<0.001). Statistically, AML children with low miR-122 expression more frequently had large white blood cell count (P=0.022), French-American-British classification subtype M7 (P<0...
June 28, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28822576/pembrolizumab-versus-ipilimumab-for-advanced-melanoma-final-overall-survival-results-of-a-multicentre-randomised-open-label-phase-3-study-keynote-006
#10
Jacob Schachter, Antoni Ribas, Georgina V Long, Ana Arance, Jean-Jacques Grob, Laurent Mortier, Adil Daud, Matteo S Carlino, Catriona McNeil, Michal Lotem, James Larkin, Paul Lorigan, Bart Neyns, Christian Blank, Teresa M Petrella, Omid Hamid, Honghong Zhou, Scot Ebbinghaus, Nageatte Ibrahim, Caroline Robert
BACKGROUND: Interim analyses of the phase 3 KEYNOTE-006 study showed superior overall and progression-free survival of pembrolizumab versus ipilimumab in patients with advanced melanoma. We present the final protocol-specified survival analysis. METHODS: In this multicentre, open-label, randomised, phase 3 trial, we recruited patients from 87 academic institutions, hospitals, and cancer centres in 16 countries (Australia, Austria, Belgium, Canada, Chile, Colombia, France, Germany, Israel, Netherlands, New Zealand, Norway, Spain, Sweden, UK, and USA)...
August 16, 2017: Lancet
https://www.readbyqxmd.com/read/28822557/family-history-of-cancer-predicts-endometrial-cancer-risk-independently-of-lynch-syndrome-implications-for-genetic-counselling
#11
Sharon E Johnatty, Yen Y Tan, Daniel D Buchanan, Michael Bowman, Rhiannon J Walters, Andreas Obermair, Michael A Quinn, Penelope B Blomfield, Alison Brand, Yee Leung, Martin K Oehler, Judy A Kirk, Tracy A O'Mara, Penelope M Webb, Amanda B Spurdle
OBJECTIVE: To determine endometrial cancer (EC) risk according to family cancer history, including assessment by degree of relatedness, type of and age at cancer diagnosis of relatives. METHODS: Self-reported family cancer history was available for 1353 EC patients and 628 controls. Logistic regression was used to quantify the association between EC and cancer diagnosis in ≥1 first or second degree relative, and to assess whether level of risk differed by degree of relationship and/or relative's age at diagnosis...
August 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28822555/influence-of-tumor-size-on-outcomes-following-pelvic-exenteration
#12
B Smith, E L Jones, M Kitano, A L Gleisner, N J Lyell, G Cheng, M D McCarter, S Abdel-Misih, F J Backes
OBJECTIVE: Pelvic exenteration (PE) is often the only curative option for locally advanced or recurrent pelvic malignancies. Despite radical surgery, recurrence risk and morbidity remain high. In this study, we sought to determine tumor size effect on perioperative outcomes and subsequent survival in patients undergoing PE. METHODS: Retrospective chart review was performed for female patients who underwent PE at two comprehensive cancer centers from 2000 to 2015...
August 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28822397/outcomes-after-mastectomy-and-lumpectomy-in-octogenarians-and-nonagenarians-with-early-stage-breast-cancer
#13
Amelia Y Merrill, Doris R Brown, Heidi D Klepin, Edward A Levine, Marissa Howard-Mcnatt
Prospective studies have shown equal outcomes after mastectomy or breast conservation in patients with invasive breast cancer; however, many of these studies excluded elderly patients. We identified patients in their eighties and nineties with clinical stage 0 to II breast cancer undergoing mastectomy or lumpectomy with or without radiation from the prospective sentinel lymph node database at Wake Forest Baptist Health and analyzed their treatment and survival. Of 92 patients, 24 (26.1%) underwent mastectomy, 22 (23...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28822395/patient-and-tumor-disparities-in-breast-cancer-based-on-insurance-status
#14
Celia Quang, Seth Hill, Scott Blair, Donna Lynn Dyess, Joe Spencer Liles
This study seeks to determine whether uninsured breast cancer patients are more likely to present with advanced disease relative to insured patients. We retrospectively reviewed newly diagnosed breast cancer patients over a 27-month period. Patients were sorted based on insurance status at diagnosis. Demographic and tumor-specific data were collected and analyzed using nonparametric testing. We identified 276 breast tumors in 260 patients. Out of the 260 patients, 71 patients (27.3%) were uninsured and were more likely to be black (P < 0...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28822389/mammographic-screening-at-age-40-or-45-what-difference-does-it-make-the-potential-impact-of-american-cancer-society-mammography-screening-guidelines
#15
Crystal E Fancher, Anthony Scott, Ahkeel Allen, Paul Dale
this is a 10-year retrospective chart review evaluating the potential impact of the most recent American Cancer Society mammography screening guidelines which excludes female patients aged 40 to 44 years from routine annual screening mammography. Instead they recommend screening mammography starting at age 45 with the option to begin screening earlier if the patient desires. The institutional cancer registry was systematically searched to identify all women aged 40 to 44 years treated for breast cancer over a 10-year period...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28822194/-effect-of-oridonin-on-apoptosis-and-intracellular-reactive-oxygen-species-level-in-triple-negative-breast-cancer-mda-mb-231-cells
#16
Qi Qi, Pei Zhang, Qi-Xiang Li, Qiong Pan, Hai-Lun Zheng, Su-Rong Zhao
Oridonin, which is an ent-kaurene diterpenoid isolated from traditional Chinese medicine Rabdosia rubescens, displays various bioactivities, including anti-inflammation, anti-bacteria and anti-tumor. This study aimed to investigate the effect of oridonin on apoptosis of triple-negative breast cancer MDA-MB-231 cells and its underlying mechanisms. The inhibitory effect of oridonin on proliferation of MDA-MB-231 cells was measured by MTT assay; Apoptosis was analyzed by flow cytometry with PI staining and Annexin V-FITC/PI staining; Intracellular reactive oxygen species (ROS) level was determined by ROS detection kit, and expressions of PARP, Bcl-2, caspase-3 were analyzed by Western blot...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28822118/risk-factors-for-lateral-neck-recurrence-of-n0-n1a-papillary-thyroid-cancer
#17
Yehree Kim, Jong-Lyel Roh, Gyungyup Gong, Kyung-Ja Cho, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim
BACKGROUND: Current guidelines advocate no prophylactic dissection of the lateral neck compartment for papillary thyroid carcinoma (PTC) without clinical evidence of lateral neck metastasis (cN1b). However, lateral neck recurrence can affect patient treatment outcomes and quality of life. Therefore, this study examined the risk factors for lateral neck recurrence after the definitive treatment of PTC without cN1b. METHODS: The study enrolled 1928 consecutive patients who underwent total thyroidectomy between 2006 and 2012 for PTC without cN1b...
August 18, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28822084/giant-biatrial-myxoma-with-two-different-gross-findings
#18
Taiyo Kuroda, Yukifusa Yokoyama, Satoshi Yuhara, Hideyuki Okawa, Hiroki Hasegawa, Jun Yokote, Shuji Tamaki, Shinji Mii
We experienced a giant biatrial myxoma concomitant with hepatocellular carcinoma. Most of myxomas originate from the left atrium, and biatrial myxomas are extremely rare. Excision of the giant cardiac tumor was performed to avoid risks of life-threatening complications. The resected mass was grossly composed of two parts with the border of interatrial septum and with the shape of peanut shell. Although microscopic examinations revealed enlarged vessels, hemorrhages and hemosiderosis in the left part and high cellularity with chronic inflammation in the right part, spindle-shaped cells in a loose myxoid stroma were observed in both parts of the tumor, consistent with the diagnosis of myxoma...
August 18, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28822078/prognostic-implication-of-the-primary-tumor-location-in-early-stage-breast-cancer-focus-on-lower-inner-zone
#19
Jiqiao Yang, Shenli Tang, Yuting Zhou, Juanjuan Qiu, Juying Zhang, Sui Zhu, Qing Lv
BACKGROUND: The aim of this study was to investigate the prognostic significance of tumor location of lower inner zone (LIZ) on the survival of patients with early-stage breast cancer. METHODS: We retrospectively identified 961 breast cancer patients from Jan 2000 to Apr 2016 from hospital database. We evaluated overall survival (OS) and disease-free survival (DFS) in patients with tumors in and outside LIZ. Subgroup analyses were performed according to clinicopathological characteristics and treatment strategies...
August 18, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28822058/immune-dysfunction-in-non-hodgkin-lymphoma-avenues-for-new-immunotherapy-based-strategies
#20
REVIEW
Lorenzo Falchi
PURPOSE OF THIS REVIEW: The present review focuses on key aspects of non-Hodgkin lymphoma (NHL) evasion of immune surveillance and how these can be leveraged to devise effective immunotherapy strategies. RECENT FINDINGS: In recent years, significant progress has been made in the field of cancer immunotherapy. In particular, the remarkable clinical results of anti-programmed death (PD)-1/PD-ligand (L)1 antibodies are revolutionizing the treatment approach to multiple solid and hematologic tumors...
August 18, 2017: Current Hematologic Malignancy Reports
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