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https://www.readbyqxmd.com/read/29913454/ra190-a-proteasome-subunit-adrm1-inhibitor-suppresses-intrahepatic-cholangiocarcinoma-by-inducing-nf-kb-mediated-cell-apoptosis
#1
Guang-Yang Yu, Xuan Wang, Su-Su Zheng, Xiao-Mei Gao, Qing-An Jia, Wen-Wei Zhu, Lu Lu, Hu-Liang Jia, Jin-Hong Chen, Qiong-Zhu Dong, Ming Lu, Lun-Xiu Qin
BACKGROUND/AIMS: Effective drug treatment for intrahepatic cholangiocarcinoma (ICC) is currently lacking. Therefore, there is an urgent need for new targets and new drugs that can prolong patient survival. Recently targeting the ubiquitin proteasome pathway has become an attractive anti-cancer strategy. In this study, we aimed to evaluate the therapeutic effect of and identify the potential mechanisms involved in targeting the proteasome subunit ADRM1 for ICC. METHODS: The expression of ADRM1 and its prognostic value in ICC was analyzed using GEO and TCGA datasets, tumor tissues, and tumor tissue arrays...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913322/culture-supernatants-of-oral-cancer-cells-induce-impaired-ifn-%C3%AE-production-of-pdcs-partly-through-the-down-regulation-of-tlr-9-expression
#2
Nannan Han, Zun Zhang, Houyu Jv, Jingzhou Hu, Min Ruan, Chenping Zhang
OBJECTIVES: The aim of the present study was to investigate whether tumor-derived supernatants down-regulate the immune function of plasmacytoid dendritic cells (pDCs) in oral cancer and the potential molecular mechanisms of this effect. MATERIALS AND METHODS: Immunohistochemistry (IHC) and flow cytometry were used to detect tumor-infiltrating and peripheral blood pDCs. MTS and flow cytometry were employed to evaluate the immune response of CD4+ T cells. Real-time PCR and ELISA assays were used to identify TLR-7 and TLR-9 expression, IFN-α production and tumor-secreted soluble cytokines...
June 5, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29913261/hydrochlorothiazide-use-and-risk-of-merkel-cell-carcinoma-and-malignant-adnexal-skin-tumors-a-nationwide-case-control-study
#3
Sidsel Arnspang Pedersen, Sigrun Alba Johannesdottir Schmidt, Lisbet Rosenkrantz Hölmich, Søren Friis, Anton Pottegård, David Gaist
BACKGROUND: Hydrochlorothiazide use has been associated with markedly increased risk of squamous cell carcinoma. No previous studies have investigated the association between hydrochlorothiazide use and the risk of Merkel cell carcinoma (MCC) and malignant adnexal skin tumors (MAST). OBJECTIVE: To examine the association between hydrochlorothiazide use and the risk of MCC and MAST. METHODS: Using Danish nationwide health registries, we identified all patients with incident MCC or MAST during 2004-2015 and matched cases individually to cancer-free population controls by risk set sampling...
June 15, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29913239/plasma-mirnas-in-diagnosis-and-prognosis-of-pancreatic-cancer-a-mirna-expression-analysis
#4
Xin Zhou, Zipeng Lu, Tongshan Wang, Zebo Huang, Wei Zhu, Yi Miao
The differential expression of microRNAs (miRNAs) in plasma of pancreatic cancer (PC) patients may act as a diagnostic biomarker. A four-stage study was performed to identify plasma miRNAs with potential in detecting PC. Exiqon panels (20 PC vs. 10 normal controls (NCs)) were applied in the screening phase to obtain miRNA profiling. The identified miRNAs were further assessed in the training (40 PC vs. 40 NCs) and testing stages (112 PC vs. 116 NCs) with qRT-PCR assays. A six-miRNA signature including up-regulated miR-122-5p, miR-125b-5p, miR-192-5p, miR-193b-3p, miR-221-3p and miR-27b-3p was identified...
June 15, 2018: Gene
https://www.readbyqxmd.com/read/29913153/pag1-promotes-the-inherent-radioresistance-of-laryngeal-cancer-cells-via-activation-of-stat3
#5
Li Shen, Qing Ke, Jingjing Chai, Chuanyi Zhang, Li Qiu, Feng Peng, Xinzhou Deng, Zhiguo Luo
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1(PAG1) is a ubiquitous protein that is essential for the development and progression of various malignancies. A previous study in our laboratory confirmed that PAG1 plays an important role in modulating the inherent radioresistance of laryngeal cancer cells, but the underlying mechanisms are still poorly defined. In this study, we found that PAG1 was significantly increased in laryngeal cancer tissues compared to adjacent non-tumor tissues (P < 0...
June 15, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29912993/plasmatic-membrane-toll-like-receptor-expressions-in-human-astrocytomas
#6
Isabele Fattori Moretti, Daiane Gil Franco, Thais Fernanda de Almeida Galatro, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie
Toll-like receptors (TLRs) are the first to identify disturbances in the immune system, recognizing pathogens such as bacteria, fungi, and viruses. Since the inflammation process plays an important role in several diseases, TLRs have been considered potential therapeutic targets, including treatment for cancer. However, TLRs' role in cancer remains ambiguous. This study aims to analyze the expression levels of plasmatic cell membrane TLRs (TLR1, TLR2, TLR4, TLR5, and TLR6) in human astrocytomas the most prevalent tumors of CNS different grades (II-IV)...
2018: PloS One
https://www.readbyqxmd.com/read/29912916/expression-of-long-noncoding-rna-malat1-correlates-with-increased-levels-of-nischarin-and-inhibits-oncogenic-cell-functions-in-breast-cancer
#7
Steven C Eastlack, Shengli Dong, Yin Y Mo, Suresh K Alahari
Malat1 is a long noncoding RNA with a wide array of functions, including roles in regulating cancer cell migration and metastasis. However, the nature of its involvement in control of these oncogenic processes is incompletely understood. In the present study, we investigate the role of Malat1 and the effects of Malat1 KO in a breast cancer cell model. Our selection of Malat1 as the subject of inquiry followed initial screening experiments seeking to identify lncRNAs which are altered in the presence or absence of Nischarin, a gene of interest previously discovered by our lab...
2018: PloS One
https://www.readbyqxmd.com/read/29912899/association-of-hogg1-ser326cys-itga2-c807t-tnf-a-308g-a-and-xpd-lys751gln-polymorphisms-with-the-survival-of-malaysian-npc-patients
#8
Eng-Zhuan Ban, Munn-Sann Lye, Pei Pei Chong, Yoke-Yeow Yap, Siew Ying Crystale Lim, Hejar Abdul Rahman
BACKGROUND: Nasopharyngeal carcinoma is a rare form of cancer across the world except in certain areas such as Southern China, Hong Kong and Malaysia. NPC is considered a relatively radiosensitive tumor and patients diagnosed at early stages tend to survive longer compared to those with advanced disease. Given that early symptoms of NPC are non-specific and that the nasopharynx is relatively inaccessible, less invasive screening methods such as biomarker screening might be the key to improve NPC survival and management...
2018: PloS One
https://www.readbyqxmd.com/read/29912871/ar-negative-triple-negative-or-quadruple-negative-breast-cancers-in-african-american-women-have-an-enriched-basal-and-immune-signature
#9
Melissa Davis, Shweta Tripathi, Raymond Hughley, Qinghua He, Sejong Bae, Balasubramanyam Karanam, Rachel Martini, Lisa Newman, Windy Colomb, William Grizzle, Clayton Yates
There is increasing evidence that Androgen Receptor (AR) expression has prognostic usefulness in Triple negative breast cancer (TNBC), where tumors that lack AR expression are considered "Quadruple negative" Breast Cancers ("QNBC"). However, a comprehensive analysis of AR expression within all breast cancer subtypes or stratified by race has not been reported. We assessed AR mRNA expression in 925 tumors from The Cancer Genome Atlas (TCGA), and 136 tumors in 2 confirmation sets. AR protein expression was determined by immunohistochemistry in 197 tumors from a multi-institutional cohort, for a total of 1258 patients analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29912804/comparison-of-outcomes-in-patients-with-muscle-invasive-bladder-cancer-treated-with-radical-cystectomy-versus-bladder-preservation
#10
Jim Zhong, Jeffrey Switchenko, Naresh K Jegadeesh, Richard J Cassidy, Theresa W Gillespie, Viraj Master, Peter Nieh, Mehrdad Alemozaffar, Omer Kucuk, Bradley Carthon, Christopher P Filson, Mehmet A Bilen, Ashesh B Jani
PURPOSE: Radical cystectomy currently remains the standard of care for muscle-invasive bladder cancer. However, surgery can be associated with considerable morbidity and mortality, including the removal of the bladder. An alternative strategy is to preserve the bladder through concurrent chemoradiation following a maximal transurethral resection of the tumor. National protocols using a bladder-preservation approach have demonstrated disease-specific outcomes comparable to radical cystectomy in selected patients, but these results have not been replicated in previously reported population-based series...
June 16, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29912760/the-role-of-insulin-like-growth-factor-igf-axis-in-early-diagnosis-of-pancreatic-adenocarcinoma-pdac
#11
Barbara Wlodarczyk, Anita Gasiorowska, Ewa Malecka-Panas
New-onset diabetes mellitus (DM) is one of the first symptoms of pancreatic adenocarcinoma (PDAC). The frequency of endocrine disorders is estimated between 40% and 80% in patients with pancreatic cancer. DM is a risk factor for cancer development but it may also be a consequence of the tumor growth. Data confirming the existence of a relationship between long standing type 2 DM and an increased risk of PDAC comes from numerous clinical studies. Insulin resistance phenomenon and hyperinsulinemia may result in the increased proliferation of pancreatic islets which in turn may cause a predisposition to cancer development...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912756/hyperlipidemia-and-nonalcoholic-steatohepatitis-predispose-to-hepatocellular-carcinoma-development-without-cirrhosis
#12
Jennifer Phan, Vivian Ng, Alan Sheinbaum, Sam French, Gina Choi, Mohamed El Kabany, Francisco Durazo, Sammy Saab, Myron Tong, Ronald Busuttil, Steven-Huy Han
BACKGROUND: Hepatocellular carcinoma (HCC) accounts for 90% of primary hepatic malignancies. With the exception of chronic hepatitis B (CHB), other etiologies of chronic liver disease require progression to cirrhosis before HCC development. Case reports have described HCC in noncirrhotic patients with hepatitis C (HCV) and nonalcoholic fatty liver disease. GOAL: The aim of this study was to determine the prevalence of patients without cirrhosis and CHB who developed HCC among a large cohort of HCC patients and to identify independent variables that are associated with no cirrhosis among patients with HCC...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912667/exploration-of-dna-methylation-markers-for-diagnosis-and-prognosis-of-patients-with-endometrial-cancer
#13
Jianchao Ying, Teng Xu, Qian Wang, Jun Ye, Jianxin Lyu
The accurate diagnosis of endometrial cancer (EC) holds great promise for improving its treatment choice and prognosis prediction. This work aimed to identify diagnostic biomarkers for differentiating EC tumors from tumors in other tissues, as well as prognostic signatures for predicting survival in EC patients. We identified 48 tissue-specific markers using a cohort of genome-wide methylation data from three common gynecological tumors and their corresponding normal tissues. A diagnostic classifier was constructed based on these 48 CpG markers that could predict cancerous versus normal tissue with an overall correct rate of 98...
June 18, 2018: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29912582/biomarkers-of-aggressiveness-in-genitourinary-tumors-with-emphasis-on-kidney-bladder-and-prostate-cancer
#14
Alessia Cimadamore, Silvia Gasparrini, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Nicola Battelli, Francesco Massari, Francesca Giunchi, Michelangelo Fiorentino, Marina Scarpelli, Rodolfo Montironi
Over the last decade, the improvement in molecular techniques and the acquisition of genomic information has transformed and increased the quality of patient care and our knowledge of diseases. Areas covered: Protein expression levels in immunohistochemistry and molecular biomarkers are reported for their ability to predict recurrence, progression, development of metastases, or patient survival. In particular, for renal cell carcinoma, we take into consideration the biomarkers applicable to immunohistochemistry and with molecular and genetic analyses...
June 18, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29912578/real-life-adjuvant-chemotherapy-uptake-and-survival-in-patients-with-non-small-cell-lung-cancer-after-complete-resection
#15
Vítězslav Kolek, Stanislav Losse, Juraj Kultan, Petr Jakubec, Jaromir Zatloukal, Milan Sova, Marek Szkorupa, Čestmír Neoral, Josef Škarda, Tomáš Tichý, Zdeněk Kolář
OBJECTIVES: Adjuvant chemotherapy (AC) in non-small cell lung cancer (NSCLC) has become a standard of care in patients with stages IIA, IIB, and IIIA after complete tumor resection. Utilization and outcome of AC in routine practice is described in a few studies with non-conclusive results. MATERIAL AND METHODS: This retrospective study included consecutive patients with NSCLC who underwent curative-intent surgery. Data of AC uptake in stage IB (tumor of ≥4 cm in diameter), II and IIIA and reasons of AC omission were evaluated according to medical records...
June 18, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29912434/evidence-based-optimization-of-post-treatment-surveillance-for-skull-base-chordomas-based-on-local-and-distant-disease-progression
#16
Jacob L Freeman, Ascher B Kaufmann, Richard G Everson, Franco DeMonte, Shaan M Raza
BACKGROUND: There are no guidelines regarding post-treatment surveillance specific to skull base chordomas. OBJECTIVE: To determine an optimal imaging surveillance schedule to detect both local and distant metastatic skull base chordoma recurrences. METHODS: A retrospective review of 91 patients who underwent treatment for skull base chordoma between 1993 and 2017 was conducted. Time to and location of local and distant recurrence(s) were cataloged...
April 18, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29912433/a-novel-long-non-coding-rna-from-nbl2-pericentromeric-macrosatellite-forms-a-perinucleolar-aggregate-structure-in-colon-cancer
#17
Gabrijela Dumbovic, Josep Biayna, Jordi Banús, Johanna Samuelsson, Anna Roth, Sven Diederichs, Sergio Alonso, Marcus Buschbeck, Manuel Perucho, Sonia-V Forcales
Primate-specific NBL2 macrosatellite is hypomethylated in several types of tumors, yet the consequences of this DNA hypomethylation remain unknown. We show that NBL2 conserved repeats are close to the centromeres of most acrocentric chromosomes. NBL2 associates with the perinucleolar region and undergoes severe demethylation in a subset of colorectal cancer (CRC). Upon DNA hypomethylation and histone acetylation, NBL2 repeats are transcribed in tumor cell lines and primary CRCs. NBL2 monomers exhibit promoter activity, and are contained within novel, non-polyA antisense lncRNAs, which we designated TNBL (Tumor-associated NBL2 transcript)...
April 18, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29912358/identifying-differentially-methylated-sites-in-samples-with-varying-tumor-purity
#18
Antti Häkkinen, Amjad Alkodsi, Chiara Facciotto, Kaiyang Zhang, Katja Kaipio, Sirpa Leppä, Olli Carpén, Seija Grénman, Johanna Hynninen, Sakari Hietanen, Rainer Lehtonen, Sampsa Hautaniemi
Motivation: DNA methylation aberrations are common in many cancer types. A major challenge hindering comparison of patient-derived samples is that they comprise of heterogeneous collection of cancer and microenvironment cells. We present a computational method that allows comparing cancer methylomes in two or more heterogeneous tumor samples featuring differing, unknown fraction of cancer cells. The method is unique in that it allows comparison also in the absence of normal cell control samples and without prior tumor purity estimates, as these are often unavailable or unreliable in clinical samples...
April 18, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29912290/accounting-for-differential-variability-in-detecting-differentially-methylated-regions
#19
Ya Wang, Andrew E Teschendorff, Martin Widschwendter, Shuang Wang
DNA methylation plays an essential role in cancer. Differential variability (DV) in cancer was recently observed that contributes to cancer heterogeneity and has been shown to be crucial in detecting epigenetic field defects, DNA methylation alterations happening early in carcinogenesis. As neighboring CpG sites are highly correlated, here, we present a new method to detect differentially methylated regions (DMRs) that uses combined signals from differential methylation and DV between sample groups. We demonstrated in simulation studies the superior performance of the new method than existing methods that use only one type of signals when true DMRs have both...
August 18, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29912279/pdcd4-suppresses-proliferation-migration-and-invasion-of-endometrial-cells-by-inhibiting-autophagy-and-nf-%C3%AE%C2%BAb-mmp2-mmp9-signal-pathway
#20
Yue Li, Xiaoyan Wang, Xishuang Wang, Lu Wan, Yanping Liu, Yongyu Shi, Lining Zhang, Zhenghui Fang, Zengtao Wei
Endometriosis (EM) is a kind of estrogen-dependent disease in reproductive-age women. Ovarian endometriosis is the most common type. Although endometriosis is a benign disease, it shares many similar features with cancers. Programmed cell death 4 (PDCD4), a newly identified tumor suppressor, plays an important role in inhibiting tumorigenesis and tumor progression at the transcriptional and translational levels. To explore the roles of PDCD4 in endometriosis, we detected the expression of PDCD4 in control endometrium and eutopic/ectopic endometrium of ovarian endometriosis patients, and analyzed the effects of PDCD4 on the biological behaviors of endometrial cell lines and primary endometrial cells...
June 15, 2018: Biology of Reproduction
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