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https://www.readbyqxmd.com/read/28339013/immunological-effects-of-occupational-exposure-to-lead-review
#1
Concettina Fenga, Silvia Gangemi, Valentina Di Salvatore, Luca Falzone, Massimo Libra
It is well-known that occupational and environmental exposure to several factors, including benzene, heavy metals, chemicals and mineral fibers, is associated with the risk of developing a great number of diseases. Numerous studies have been carried out in order to investigate the mechanisms of toxicity of these substances, with particular regard to the possible toxic effects on the immune system. However, little is known about the influence of heavy metals, such as lead, on the immune system in human populations...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338674/biofilm-formation-enables-free-living-nitrogen-fixing-rhizobacteria-to-fix-nitrogen-under-aerobic-conditions
#2
Di Wang, Anming Xu, Claudine Elmerich, Luyan Z Ma
The multicellular communities of microorganisms known as biofilms are of high significance in agricultural setting, yet it is largely unknown about the biofilm formed by nitrogen-fixing bacteria. Here we report the biofilm formation by Pseudomonas stutzeri A1501, a free-living rhizospheric bacterium, capable of fixing nitrogen under microaerobic and nitrogen-limiting conditions. P. stutzeri A1501 tended to form biofilm in minimal media, especially under nitrogen depletion condition. Under such growth condition, the biofilms formed at the air-liquid interface (termed as pellicles) and the colony biofilms on agar plates exhibited nitrogenase activity in air...
March 24, 2017: ISME Journal
https://www.readbyqxmd.com/read/28337700/experimental-research-showing-the-reduction-of-naloxone-place-aversion-by-oral-zinc-administration-in-rats
#3
Diana Ciubotariu, Raoul Vasile Lupușoru, Elena Luca, Liliana Mititelu-Tarțău, Cătălina Elena Lupușoru
Previous studies showed the attenuation of both morphine-dependence and morphine-place preference by zinc. Conditioned place preference and aversion are experimental models frequently used to test the reward-stimulating, respectively the aversive effects induced by different stimuli or substances. Addictive substances usually induce place preference (exhibit reward-stimulating properties), while their antagonists determine place-avoidance (aversion). The present study aimed to assess the effect determined by zinc sulphate oral administration (2 and 4 mg/kg/day, 14 days, prior to habituation) on the place aversion induced by two naloxone doses (1...
March 23, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28335530/risk-of-suicide-and-dysfunctional-patterns-of-personality-among-bereaved-substance-users
#4
Laura Masferrer, Beatriz Caparrós
Background: Research has shown that suicide is a phenomenon highly present among the drug dependent population. Different studies have demonstrated an upraised level of comorbidity between personality disorders (PD) and substance use disorders (SUD). This study aimed to describe which PDs are more frequent among those patients with a risk of suicide. Methods: The study was based on a consecutive non-probabilistic convenience sample of 196 bereaved patients attended to in a Public Addiction Center in Girona (Spain)...
March 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28334671/fast-tracking-the-molecular-weight-changes-of-humic-substances-in-coagulation-flocculation-processes-via-fluorescence-eem-parafac
#5
Bilal Aftab, Jin Hur
The removal of a commercial humic acid (HA) and changes in its chemical composition were examined for coagulation/flocculation (C/F) processes based on jar tests using two different coagulants at a wide range of pH. ZrCl4 showed a better performance in eliminating HA than Al2SO4 with the same removal rates at lower dosages. The highest removal rates were found at a neutral pH range (5.0-6.5). The HA was further decomposed into three different humic-like components (C1, C2, and C3) by excitation emission matrix coupled with parallel factor analysis (EEM-PARAFAC)...
March 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28333571/screening-and-assessment-of-substance-use-in-hospice-care-examining-content-from-a-national-sample-of-psychosocial-assessments
#6
Paul Sacco, John G Cagle, Melissa L Moreland, Elizabeth A S Camlin
BACKGROUND: Quality of care provided by hospice and palliative care agencies depends on a thorough understanding of the patient, the family, their history, and current risk factors. It is therefore imperative for social workers and other providers in these settings to assess patients and caregivers for substance use disorders and potential for substance misuse. OBJECTIVE: We aimed to examine how hospice social workers in the United States screen and assess for alcohol and substance use and risk of medication diversion among patients and family caregivers...
March 23, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28333535/family-based-treatments-for-serious-juvenile-offenders-a-multilevel-meta-analysis
#7
Alex R Dopp, Charles M Borduin, Mark H White, Sofie Kuppens
OBJECTIVE: Researchers have identified several family-based treatments that hold considerable promise in reducing serious juvenile offending; however, these treatments remain underutilized by youth service systems. In the present study, we used meta-analysis to summarize the findings of research on family-based treatments for serious juvenile offenders. METHOD: We conducted a multilevel meta-analysis that modeled dependencies between multiple effect sizes from the same study...
April 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28330706/eating-dependence-and-weight-gain-no-human-evidence-for-a-sugar-addiction-model-of-overweight
#8
C Rob Markus, Peter J Rogers, Fred Brouns, Robbie Schepers
BACKGROUND AND AIMS: There is an increasing societal concern that consumption of specific foods such as sugar might become 'addictive' and, hence, promote weight gain. Claims about the addictiveness of sugar however are based largely on findings from few animal studies, whereas there is a lack of direct human evidence for symptoms of sugar-related substance dependence. The current study examined in a large sample of human participants whether foods mainly containing sugar in particular might cause 'addiction-like' problems that meet clinical DSM criteria for substance dependence, and, also whether in turn this relates to body weight and negative affectivity (depressed mood)...
March 19, 2017: Appetite
https://www.readbyqxmd.com/read/28330500/larvicidal-activity-of-phytosteroid-compounds-from-leaf-extract-of-solanum-nigrum-against-culex-vishnui-group-and-anopheles-subpictus
#9
Anjali Rawani, Anushree Singha Ray, Anupam Ghosh, Mary Sakar, Goutam Chandra
BACKGROUND: Vector control is facing a menace due to the appearance of resistance to synthetic insecticides. Insecticides of plant origin may provide appropriate substitute biocontrol techniques in the future. The present study was carried out to investigate the bio control potentiality of active ingredient isolated from chloroform: methanol (1:1 v/v) extract of mature leaves of Solanum nigrum L. (Solanaceae) against early 3rd instar larvae of Culex vishnui group (comprising of Cx. vishnui Theobald, Cx...
March 23, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28330465/the-impact-of-non-response-bias-due-to-sampling-in-public-health-studies-a-comparison-of-voluntary-versus-mandatory-recruitment-in-a-dutch-national-survey-on-adolescent-health
#10
Kei Long Cheung, Peter M Ten Klooster, Cees Smit, Hein de Vries, Marcel E Pieterse
BACKGROUND: In public health monitoring of young people it is critical to understand the effects of selective non-response, in particular when a controversial topic is involved like substance abuse or sexual behaviour. Research that is dependent upon voluntary subject participation is particularly vulnerable to sampling bias. As respondents whose participation is hardest to elicit on a voluntary basis are also more likely to report risk behaviour, this potentially leads to underestimation of risk factor prevalence...
March 23, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28330427/comparison-of-airway-response-in-na%C3%A3-ve-and-ovalbumin-sensitized-mice-during-short-term-inhalation-exposure-to-chlorine
#11
Mia Johansson, Åsa Gustafsson, Gunnar Johanson, Mattias Öberg
OBJECTIVE: It has been suggested that asthmatics are more susceptible than healthy individuals to airborne irritating chemicals in general. However, there is limited human data available to support this hypothesis due to ethical and practical difficulties. We explored a murine model of ovalbumin (OVA)-induced airway inflammation to study susceptibility during acute exposure to chemicals with chlorine as a model substance. METHODS: Naïve and OVA sensitized female BALB/c mice were exposed to chlorine at four different concentrations (0, 5, 30 and 80 ppm) for 15 minutes with online recording of the respiratory function by plethysmography...
February 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28329841/using-latent-class-analysis-to-identify-profiles-of-elder-abuse-perpetrators
#12
Marguerite DeLiema, Jeanine Yonashiro-Cho, Zach D Gassoumis, Yongjie Yon, Ken J Conrad
Objectives: Research suggests that abuser risk factors differ across elder mistreatment types, but abuse interventions are not individualized. To move away from assumptions of perpetrator homogeneity and to inform intervention approaches, this study classifies abusers into subtypes according to their behavior profiles. Method: Data are from the Older Adult Mistreatment Assessment administered to victims by Adult Protective Service (APS) in Illinois. Latent class analysis was used to categorize abusers (N = 336) using victim and caseworker reports on abusers' harmful and supportive behaviors and characteristics...
March 8, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28327055/the-evaluation-of-the-anti-cancer-activity-of-ixazomib-on-caco2-colon-solid-tumor-cells-comparison-with-bortezomib
#13
Selin Engür, Miriş Dikmen
Proteasome inhibition has recently emerged as a clinically effective anticancer therapeutic approach. The first proteasome inhibitor, bortezomib (Velcade, PS-341), and new proteasome inhibitors including ixazomib have become more important in the development of targeted cancer therapies. Under physiological conditions, MLN9708 (ixazomib citrate), the stable citrate ester drug substance, hydrolyzes rapidly to MLN2238 (ixazomib), the biologically active boronic acid. It is a second-generation proteasome inhibitor, similar to the well-known proteasome inhibitor bortezomib, which is currently being investigated in phase 3 trials as a treatment for multiple Myeloma...
March 22, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28325510/increased-nuclear-localization-of-substance-p-in-human-gastric-tumor-cells
#14
Miguel Muñoz, Marisa Rosso, Andrés Carranza, Rafael Coveñas
Gastric cancer (GC) is an aggressive disease that remains the fourth most common type of cancer and is the second leading cause of cancer-related death worldwide. Treatment of advanced or metastatic GC has seen little progress and median overall survival in this group remains <1 year. It is urgent to investigate new mechanisms to understand GC progression. It is known that substance P (SP), after binding to the neurokinin-1 (NK-1) receptor, elicits GC proliferation; that GC cells and samples express NK-1 receptors; that NK-1 receptor antagonists, in a concentration dependent manner, inhibit the proliferation of GC cells and that these cells die by apoptosis...
March 18, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28324840/biosorption-of-diethyl-phthalate-ester-by-living-and-nonliving-burkholderia-cepacia-and-the-role-of-its-cell-surface-components
#15
Si Luo, Langlang Li, Anwei Chen, Qingru Zeng, Hao Xia, Ji-Dong Gu
In this study, the dibutyl phthalate (DBP) binding properties of a DBP-tolerant bacterium (B. cepacia) were characterized in terms of adsorption kinetics and isotherm. Living and nonliving cells both exhibited rapid removal of DBP, achieving more than 80% of maximum sorption within 30 min of contact and reached the equilibrium after 3 h. The adsorption isotherms were well fitted with the Sips model and the nonliving cells have greater biosorption capacity and affinity for DBP than the living cells. Furthermore, the absence of an active mechanism dependent on metabolism implied that the DBP bioaccumulation by living cells was mainly attribute to passive surface binding...
March 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28324627/hospitalized-opioid-dependent-patients-exploring-predictors-of-buprenorphine-treatment-entry-and-retention-after-discharge
#16
Christina S Lee, Jane M Liebschutz, Bradley J Anderson, Michael D Stein
OBJECTIVES: Few studies have explored predictors of entry into and retention in buprenorphine treatment following linkage from an acute medical hospitalization. METHODS: This secondary analysis of a completed clinical trial focuses on medically hospitalized, opioid-dependent patients (n = 72) who were randomized to an intervention including buprenorphine induction and dose stabilization during hospitalization followed by post-discharge transition to office-based buprenorphine treatment (OBOT)...
March 21, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28323939/tac1-gene-products-regulate-pituitary-hormone-secretion-and-gene-expression-in-prepubertal-grass-carp-pituitary-cells
#17
Guangfu Hu, Mulan He, Wendy K W Ko, Anderson O L Wong
Tachykinin 1 (TAC1) is known to have diverse functions in mammals but similar information is scarce in lower vertebrates including fish species. Using grass carp as a model, the pituitary actions, receptor specificity and post-receptor signaling of TAC1 gene products, namely substance P (SP) and neurokinin A (NKA), were examined. As a first step, TAC1 encoding carp SP and NKA as well as tachykinin receptors NK1R and NK2R were cloned in carp pituitary. Expression studies revealed that the newly cloned receptors were functional and with pharmacological properties similar to mammalian counterparts...
March 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323526/addiction-to-snake-venom
#18
Saibal Das, Preeti Barnwal, Tanay Maiti, Anand Ramasamy, Somnath Mondal, Dinesh Babu
The nature of addiction depends on various factors. The tendency to have already used several addictive substances and to seek high sensation experiences as a result of specific personality traits may lead to extreme and peculiar forms of addictions. Even belonging to specific social and cultural background may lead to such forms of addiction such as intentional snake bite and willful envenomation. In this article, we have discussed the peculiarities and practical insight of such addiction to snake venom. The possible molecular mechanism behind such venom-mediated reinforcement has also been highlighted...
March 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28323506/emotional-and-psychosocial-factors-associated-with-drunkenness-and-the-use-of-tobacco-and-cannabis-in-adolescence-independent-or-interactive-effects
#19
Irene García-Moya, María José Ortiz Barón, Carmen Moreno
BACKGROUND: Although previous research has examined emotional and psychosocial factors associated with substance use, there is a paucity of studies examining both at the same time, and insufficient attention has been paid to how these factors may interact. OBJECTIVES: The aim of this study was to simultaneously examine the contributions from emotional (emotional control and depression) and psychosocial (peers' conventional behavior, peers' substance use and parent-child relationships) factors to drunkenness and the use of tobacco and cannabis in adolescence...
March 21, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28320840/k-channel-kv3-4-is-essential-for-axon-growth-by-limiting-the-influx-of-ca-2-into-growth-cones
#20
Chia-Yi Huang, Cheng-Chang Lien, Chau-Fu Cheng, Ting-Yun Yen, Chieh-Ju Chen, Meei-Ling Tsaur
Membrane excitability in the axonal growth cones of embryonic neurons influences axon growth. Voltage-gated K(+) (Kv) channels are key factors in controlling membrane excitability, but whether they regulate axon growth remains unclear. Here, we report that Kv3.4 is expressed in the axonal growth cones of embryonic spinal commissural neurons, motoneurons, dorsal root ganglion neurons, retinal ganglion cells and callosal projection neurons during axon growth. Our in vitro (cultured dorsal spinal neurons of chick embryos) and in vivo (developing chick spinal commissural axons and rat callosal axons) findings demonstrate that knockdown of Kv3...
March 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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