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https://www.readbyqxmd.com/read/28454009/environmental-risk-assessment-of-effluents-as-a-whole-emerging-contaminant-efficiency-of-alternative-tertiary-treatments-for-wastewater-depuration
#1
B Díaz-Garduño, M G Pintado-Herrera, M Biel-Maeso, J J Rueda-Márquez, P A Lara-Martín, J A Perales, M A Manzano, C Garrido-Pérez, M L Martín-Díaz
Emerging contaminants (ECs) and regulated compounds (RCs) from three different WWTP effluents were measured in the current study. The efficiency of two tertiary treatments, Photobiotreatment (PhtBio) and Multi-Barrier Treatment (MBT), for removing contaminants was determined. Results indicated different percentages of removal depending on the treatment and the origin of the effluent. Risk Quotients (RQs) were determined for different species of algae, Daphnia, and fish. RQ results revealed diverse risk values depending on the bioindicator species...
April 10, 2017: Water Research
https://www.readbyqxmd.com/read/28453538/variation-of-iron-redox-kinetics-and-its-relation-with-molecular-composition-of-standard-humic-substances-at-circumneutral-ph
#2
Ying Ping Lee, Manabu Fujii, Tetsuro Kikuchi, Koumei Terao, Chihiro Yoshimura
Oxidation and reduction kinetics of iron (Fe) and proportion of steady-state Fe(II) concentration relative to total dissolved Fe (steady-state Fe(II) fraction) were investigated in the presence of various types of standard humic substances (HS) with particular emphasis on the photochemical and thermal reduction of Fe(III) and oxidation of Fe(II) by dissolved oxygen (O2) and hydrogen peroxide (H2O2) at circumneutral pH (pH 7-8). Rates of Fe(III) reduction were spectrophotometrically determined by a ferrozine method under the simulated sunlight and dark conditions, whereas rates of Fe(II) oxidation were examined in air-saturated solution using luminol chemiluminescence technique...
2017: PloS One
https://www.readbyqxmd.com/read/28448631/biofortification-se-does-it-increase-the-content-of-phenolic-compounds-in-virgin-olive-oil-voo
#3
Roberto D'Amato, Primo Proietti, Andrea Onofri, Luca Regni, Sonia Esposto, Maurizio Servili, Daniela Businelli, Roberto Selvaggini
Extra-Virgin Olive Oil (EVOO) is a fundamental component of the Mediterranean diet and it may contain several anti-oxidant substances, such as phenols. Previous research has shown that this food may be enriched in phenols by spraying a sodium-selenate solution (100 mg L-1 Se) onto the crop canopy before flowering. The aim of this research was to evaluate the effect of this Se-fertilization before flowering (cv. Leccino) on the phenolic profile of EVOOs, and test to what extent such effects depend on the weather pattern, as observed in two contrasting experimental seasons (2013 and 2014)...
2017: PloS One
https://www.readbyqxmd.com/read/28447976/method-of-direct-segmental-intra-hepatic-delivery-using-a-rat-liver-hilar-clamp-model
#4
Eliza W Beal, Curtis Dumond, Jung-Lye Kim, Khalid Mumtaz, Don Hayes, Ken Washburn, Bryan A Whitson, Sylvester M Black
Major hepatic surgery with inflow occlusion, and liver transplantation, necessitate a period of warm ischemia, and a period of reperfusion leading to ischemia/reperfusion (I/R) injury with myriad negative consequences. Potential I/R injury in marginal organs destined for liver transplantation contributes to the current donor shortage secondary to a decreased organ utilization rate. A significant need exists to explore hepatic I/R injury in order to mediate its impact on graft function in transplantation. Rat liver hilar clamp models are used to investigate the impact of different molecules on hepatic I/R injury...
April 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28445303/lifetime-and-recent-alcohol-use-and-bone-mineral-density-in-adults-with-hiv-infection-and-substance-dependence
#5
Alicia S Ventura, Michael R Winter, Timothy C Heeren, Meg M Sullivan, Alexander Y Walley, Michael F Holick, Gregory J Patts, Seville M Meli, Jeffrey H Samet, Richard Saitz
Low bone mineral density (BMD) is common in people living with HIV infection (PLWH), increasing fracture risk. Alcohol use is also common in PLWH and is a modifiable risk factor for both HIV disease progression and low BMD. In PLWH, alcohol's effect on BMD is not well understood.We studied adult PLWH with substance dependence. We measured lifetime alcohol use (kg) and recent (i.e., past 30-day) alcohol use (categorized as: abstinent, low risk, or high risk). In adjusted multivariable regression analyses, we tested associations between lifetime and recent alcohol use and (i) mean BMD (g/cm) at the femoral neck, total hip, and lumbar spine and (ii) low BMD diagnosis (i...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28442735/novel-antibiotic-screening-methods-to-awaken-silent-or-cryptic-secondary-metabolic-pathways-in-actinomycetes
#6
REVIEW
Hiroyasu Onaka
Streptomyces have the potential to produce more than 30 secondary metabolites; however, the expression of most metabolite biosynthetic gene clusters is cryptic or silent. Indeed, the expression of these genes is conditional and dependent on culture conditions. To activate such gene clusters, many methods have been developed. In this review, I describe two activation approaches developed in my laboratory: use of the activation mediator goadsporin and combined-culture. Goadsporin is a chemical substance isolated from Streptomyces sp...
April 26, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28441497/development-of-a-biorelevant-material-sparing-membrane-flux-test-for-rapid-screening-of-bioavailability-enhancing-drug-product-formulations
#7
Aaron M Stewart, Michael E Grass, Deanna M Mudie, Michael M Morgen, Dwayne T Friesen, David T Vodak
Bioavailability-enhancing formulations are often used to overcome challenges of poor gastrointestinal solubility for drug substances developed for oral administration. Conventional in vitro dissolution tests often do not properly compare such formulations due to the many different drug species that may exist in solution. To overcome these limitations, we have designed a practical in vitro membrane flux test, requiring minimal active pharmaceutical ingredient (API) and capable of rapidly screening many drug product intermediates...
April 25, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28440194/concurrent-use-of-cannabis-and-alcohol-neuropsychiatric-effects-and-consequences
#8
Anna Romaguera, Marta Torrens, Esther Papaseit, Ana Lucia Arellano, Magi Farré
Concurrent use of cannabis and alcohol is frequent. According different studies, the prevalence is among 20-34% depending on different samples studied. In contrast with the wide evidence available about neuropsychiatric effects associated to the use of cannabis or alcohol separately, there are few studies of the neuropsychiatric effects of their combination. Our aim was to review the literature regarding this topic. We performed a search in MEDLINE and from 114 potentially eligible studies, 27 were selected...
April 19, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28436744/cognitive-screening-in-substance-users-diagnostic-accuracies-of-the-mini-mental-state-examination-addenbrooke-s-cognitive-examination-revised-and-montreal-cognitive-assessment
#9
Nicole Ridley, Jennifer Batchelor, Brian Draper, Apo Demirkol, Nicholas Lintzeris, Adrienne Withall
INTRODUCTION: Despite the considerable prevalence of cognitive impairment in substance-using populations, there has been little investigation of the utility of cognitive screening measures within this context. In the present study the accuracy of three cognitive screening measures in this population was examined-the Mini-Mental State Examination (MMSE), the Addenbrooke's Cognitive Examination-Revised (ACE-R), and the Montreal Cognitive Assessment (MoCA). METHOD: A sample of 30 treatment-seeking substance users and 20 healthy individuals living in the community were administered the screening measures and a neuropsychological battery (NPB)...
April 24, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28436633/-lc-ms-guided-approach-to-discovering-nephroprotective-substances-from-huangkui-capsule
#10
Tingting Ma, Yi Wang, Xiaoqian Chen, Xiaoping Zhao
Objective: To discover the nephroprotective substances from Huangkui capsule. Methods: The components of Huangkui capsule were isolated by preparative liquid chromatography, and the active components were screened by LC/MS and identified. The adriamycine-injured HK-2 cells were treated with various active components with different concentrations, and the malonaldehyde (MDA) content, adenosine triphosphate (ATP) level and mitochondrial oxygen consumption rate were measured to verify the protective activity of the compounds...
January 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28436446/opioid-self-administration-is-attenuated-by-early-life-experience-and-gene-therapy-for-anti-inflammatory-il-10-in-the-nucleus-accumbens-of-male-rats
#11
Michael J Lacagnina, Ashley M Kopec, Stewart S Cox, Richa Hanamsagar, Corinne Wells, Susan Slade, Peter M Grace, Linda R Watkins, Edward D Levin, Staci D Bilbo
Early-life conditions can contribute to the propensity for developing neuropsychiatric disease, including substance abuse disorders. However, the long-lasting mechanisms that shape risk or resilience for drug addiction remain unclear. Previous work has shown that a neonatal handling procedure in rats (which promotes enriched maternal care) attenuates morphine conditioning, reduces morphine-induced glial activation, and increases microglial expression of the anti-inflammatory cytokine interleukin-10 (IL-10)...
April 24, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28436036/oxidative-behavior-of-catechin-in-the-presence-of-inactive-dry-yeasts-a-comparison-with-sulfur-dioxide-ascorbic-acid-and-glutathione
#12
Piergiorgio Comuzzo, Rosanna Toniolo, Franco Battistutta, Marion Lizee, Rossella Svigelj, Roberto Zironi
BACKGROUND: The antioxidant capacity of an inactive dry yeast preparation (YD) was investigated by conventional analytical methods (spectrophotometry, HPLC) as well as by cyclic voltammetry (CV), in a (+)-catechin model wine and compared with certain of the most common antioxidants found in wine: sulfur dioxide, ascorbic acid and glutathione. RESULTS: Sulfur dioxide (SO2 ) was the highest performing substance in protecting (+)-catechin against browning, followed by ascorbic acid and the YD preparation...
April 24, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28433628/ca-2-dependent-hyperpolarization-hypothesis-for-mammalian-sleep
#13
REVIEW
Fumiya Tatsuki, Koji L Ode, Hiroki R Ueda
The detailed molecular mechanisms underlying the regulation of sleep/wake cycles in mammals are elusive. In this regulation, at least two mechanisms with fast and slow time scales are involved. In the faster time scale, a state of non-rapid-eye-movement (NREM) sleep can be microscopically characterized by the millisecond-to-second-order electrical behavior of neurons, namely slow-wave oscillations described by electrophysiology. In the slower time scale, the total duration of NREM sleep is homeostatically regulated by sleep pressure (the need for sleep), which is usually sustained for hours or even days and can be macroscopically described by electroencephalogram (EEG)...
April 19, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28431548/water-pipe-smoke-condensate-increases-the-internalization-of-mycobacterium-bovis-of-type-ii-alveolar-epithelial-cells-a549
#14
Esmaeil Mortaz, Shamila D Alipoor, Masoud Movassaghi, Mohammad Varahram, Jahangir Ghorbani, Gert Folkerts, Johan Garssen, Ian M Adcock
BACKGROUND: Tuberculosis (TB) is a major global health problem, and there is an association between tobacco smoke and TB. Water pipe smoking has become an increasing problem not only in Middle Eastern countries but also globally because users consider it as safer than cigarettes. The presence of high levels of toxic substances in water-pipe smoke may be a predisposing factor that enhances the incidence of pulmonary disorders. For example, uncontrolled macropinocytosis in alveolar epithelial cells following exposure to water-pipe smoke may predispose subjects to pulmonary infection...
April 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28431292/cannabis-and-cue-induced-craving-in-cocaine-dependent-individuals-a-pilot-study
#15
K Giasson-Gariépy, S Potvin, M Ghabrash, J Bruneau, D Jutras-Aswad
BACKGROUND: Cannabis consumption is common among cocaine users; however, little is known about its effect on cocaine craving. The objective of this study was to assess whether cannabis co-use is associated with lower cue-induced cocaine craving in non-treatment-seeking cocaine-dependent individuals. METHODS: Data from twenty-eight cocaine-dependent men were analyzed in this pilot study. Cocaine-dependent subjects (n=12) were compared with cocaine-dependent subjects who also abused or were dependent on cannabis (n=16)...
March 30, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28430617/estrogen-receptors-involvement-in-intervertebral-discogenic-pain-of-the-elderly-women-colocalization-and-correlation-with-the-expression-of-substance-p-in-nucleus-pulposus
#16
Xiao-Xing Song, Sheng Shi, Zhen Guo, Xin-Feng Li, Bu-Wei Yu
Estrogenic modulation of pain is an exceedingly complex phenomenon. However, whether estrogen is involved in discogenic low back pain still remains unclear. Here, immunoreactivity staining technique was used to examine the expression level of the estrogen receptors (ERα and ERβ) and a pain related neuropeptide, Substance P in the lumbar intervertebral discs to analyze the relationship between the ERs and Substance P. Nucleus pulposus tissues of 23 elderly female patients were harvested during spinal surgeries and made to detect the immunoreactivity staining of ERα, ERβ and Substance P...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429885/intravenous-self-administration-of-benzydamine-a-non-steroidal-anti-inflammatory-drug-with-a-central-cannabinoidergic-mechanism-of-action
#17
Riccardo Avvisati, Maria Meringolo, Emiliana Stendardo, Elisa Malavasi, Silvia Marinelli, Aldo Badiani
Benzydamine (BZY) is a non-steroidal anti-inflammatory drug used for the topical treatment of inflammations of the oral and vaginal mucosae. Virtually nothing is known about the central pharmacological actions of BZY. Yet there are reports of voluntary systemic overdosage of BZY in drug addicts, resulting in a euphoric, hallucinatory state. In the present study, we investigated the reinforcing properties of BZY in a rat self-administration paradigm. We found that BZY has a powerful reinforcing effect and that this effect is greatly facilitated in animals that already had substance experience, having previously self-administered heroin and cocaine, indicating cross sensitization between BZY and other common drugs of abuse...
April 21, 2017: Addiction Biology
https://www.readbyqxmd.com/read/28428763/adhd-lifestyles-and-comorbidities-a-call-for-an-holistic-perspective-from-medical-to-societal-intervening-factors
#18
REVIEW
Simon Weissenberger, Radek Ptacek, Martina Klicperova-Baker, Andreja Erman, Katerina Schonova, Jiri Raboch, Michal Goetz
The review examines Attention Deficit Hyperactivity Disorder (ADHD in its Child and Adult form) and its various presentations (Hyperactive Impulsive, Inattentive, and Combined) with a particular focus on environmental (incl. social factors), lifestyles and comorbidities. It is argued that ADHD is best understood in a holistic and interactive context and a vast empirical literature is presented to illustrate the point: Environmental factors include stress in general as well as exposure to toxins (phthalates, bisphenol A)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28427398/euphorbia-dracunculoides-l-abrogates-carbon-tetrachloride-induced-liver-and-dna-damage-in-rats
#19
Riffat Batool, Muhammad Rashid Khan, Muhammad Majid
BACKGROUND: Evaluation of Euphorbia dracunculoides of family Euphorbiaceae during previous studies had established the in vitro antioxidant and in vivo anti-inflammatory activities. The plant is used by the local communities of Pakistan for various disorders including rheumatism and edema. In this investigation we have evaluated the hepatoprotective effects against CCl4 induced toxicity in rat. METHODS: Dry powder of the aerial parts of E. dracunculoides was extracted with 95% methanol to get the extract (EDME)...
April 20, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28427157/the-anti-tumor-efficacy-of-3c23k-a-glyco-engineered-humanized-anti-misrii-antibody-in-an-ovarian-cancer-model-is-mainly-mediated-by-engagement-of-immune-effector-cells
#20
Pauline Estupina, Alexandre Fontayne, Jean-Marc Barret, Nathalie Kersual, Olivier Dubreuil, Marion Le Blay, Alexandre Pichard, Marta Jarlier, Martine Pugnière, Maëva Chauvin, Thierry Chardès, Jean-Pierre Pouget, Emmanuel Deshayes, Alexis Rossignol, Toufik Abache, Christophe de Romeuf, Aurélie Terrier, Lucie Verhaeghe, Christine Gaucher, Jean-François Prost, André Pèlegrin, Isabelle Navarro-Teulon
Ovarian cancer is the leading cause of death in women with gynecological cancers and despite recent advances, new and more efficient therapies are crucially needed. Müllerian Inhibiting Substance type II Receptor (MISRII, also named AMHRII) is expressed in most ovarian cancer subtypes and is a novel potential target for ovarian cancer immunotherapy. We previously developed and tested 12G4, the first murine monoclonal antibody (MAb) against human MISRII. Here, we report the humanization, affinity maturation and glyco-engineering steps of 12G4 to generate the Fc-optimized 3C23K MAb, and the evaluation of its in vivo anti-tumor activity...
February 24, 2017: Oncotarget
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