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End stage of heart failure

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https://www.readbyqxmd.com/read/29774592/risk-factors-for-stroke-on-left-ventricular-assist-devices
#1
Muath Bishawi, Jeremy Joseph, Chetan Patel, Jacob Schroder, Mani Daneshmand, Dawn Bowles, Joseph Rogers, Carmelo Milano
BACKGROUND: Patients with end-stage heart failure on left ventricular assist devices (LVADs) are predisposed to a high incidence of stroke. Preoperative factors associated with increased stroke risk are poorly understood. METHODS: We performed a single-center retrospective review of all patients from 2009 to 2014 in whom a rotary flow LVAD was implanted. All patients with symptoms of a cerebrovascular event underwent a non-contrast head computed tomography scan...
May 17, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29774558/clinical-outcome-and-comparison-of-three-different-left-ventricular-assist-devices-in-a-high-risk-cohort
#2
Konstantin Zhigalov, Ahmed Mashhour, Marcin Szczechowicz, Sabreen Mkalaluh, Sergei Karagezian, Irakli Gogia, Maxim Isaev, Bakitbek K Kadyraliev, Jerry Easo, Juergen Ennker, Harald C Eichstaedt, Alexander Weymann
We present a comparison between three left ventricular assist devices (LVADs): HeartWare (HVAD) (HeartWare International Inc., Framingham, MA, USA), HeartMate II (HMII) and HeartMate III (HMIII) (Thoratec Corp., Pleasanton, CA, USA). To our knowledge, no study to date has aimed at placing these three devices in juxtaposition. Between June 2007 and June 2017, 108 consecutive patients received HMII, n = 77 (71.3%), HVAD, n = 14 (13%), or HM III, n = 17 (15.7%), for end-stage heart failure. Mean age was 63...
May 17, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29766347/towards-alternative-approaches-for-coupling-of-a-soft-robotic-sleeve-to-the-heart
#3
Markus A Horvath, Claudia E Varela, Eimear B Dolan, William Whyte, David S Monahan, Christopher J Payne, Isaac A Wamala, Nikolay V Vasilyev, Frank A Pigula, David J Mooney, Conor J Walsh, Garry P Duffy, Ellen T Roche
Efficient coupling of soft robotic cardiac assist devices to the external surface of the heart is crucial to augment cardiac function and represents a hurdle to translation of this technology. In this work, we compare various fixation strategies for local and global coupling of a direct cardiac compression sleeve to the heart. For basal fixation, we find that a sutured Velcro band adheres the strongest to the epicardium. Next, we demonstrate that a mesh-based sleeve coupled to the myocardium improves function in an acute porcine heart failure model...
May 15, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29759673/characterization-of-ventricular-tachycardia-after-left-ventricular-assist-device-implantation-as-destination-therapy-a-single-center-ablation-experience
#4
Joshua D Moss, Erin E Flatley, Andrew D Beaser, John H Shin, Hemal M Nayak, Gaurav A Upadhyay, Martin C Burke, Valluvan Jeevanandam, Nir Uriel, Roderick Tung
OBJECTIVES: This study sought to report mechanisms of ventricular tachycardia (VT) and outcomes of VT ablation in patients with a left ventricular assist device (LVAD) as destination therapy. BACKGROUND: Continuous flow LVAD implantation plays a growing role in the management of end-stage heart failure, and VT is common. There are limited reports of VT ablation in patients with a destination LVAD. METHODS: Patients with a continuous-flow LVAD referred for VT ablation from 2010 to 2016 were analyzed retrospectively...
December 11, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29754170/cardiac-support-device-asd-delivers-bone-marrow-stem-cells-repetitively-to-epicardium-has-promising-curative-effects-in-advanced-heart-failure
#5
Shizhong Yue, Muhammad Naveed, Wang Gang, Dingding Chen, Zhijie Wang, Feng Yu, Xiaohui Zhou
Ventricular restraint therapy is a non-transplant surgical option for the management of advanced heart failure (HF). To augment the therapeutic applications, it is hypothesized that ASD shows remarkable capabilities not only in delivering stem cells but also in dilated ventricles. Male SD rats were divided into four groups (n = 6): normal, HF, HF + ASD, and HF + ASD-BMSCs respectively. HF was developed by left anterior descending (LAD) coronary artery ligation in all groups except normal group. Post-infarcted electrocardiography (ECG) and brain natriuretic peptide (BNP) showed abnormal heart function in all model groups and HF + ASD-BMSCs group showed significant improvement as compared to other HF, HF + ASD groups on day 30...
May 12, 2018: Biomedical Microdevices
https://www.readbyqxmd.com/read/29750814/one-year-mortality-after-recovery-from-critical-illness-a-retrospective-cohort-study
#6
Sharukh Lokhandwala, Ned McCague, Abdullah Chahin, Braiam Escobar, Mengling Feng, Mohammad M Ghassemi, David J Stone, Leo Anthony Celi
RATIONALE: Factors associated with one-year mortality after recovery from critical illness are not well understood. Clinicians generally lack information regarding post-hospital discharge outcomes of patients from the intensive care unit, which may be important when counseling patients and families. OBJECTIVE: We sought to determine which factors among patients who survived for at least 30 days post-ICU admission are associated with one-year mortality. METHODS: Single-center, longitudinal retrospective cohort study of all ICU patients admitted to a tertiary-care academic medical center from 2001-2012 who survived ≥30 days from ICU admission...
2018: PloS One
https://www.readbyqxmd.com/read/29750405/heartmate-3-implantation-via-left-antero-lateral-thoracotomy-to-avoid-resternotomy-in-high-risk-patients
#7
Raymond Pfister, Piergiorgio Tozzi, Roger Hullin, Patrick Yerly, Fritz-Patrick Jahns, René Prêtre, Matthias Kirsch
Left ventricular assist devices (LVADs) are currently the best alternative to cardiac transplantation for patients with end-stage heart failure (HF) as a bridge to transplant or to decision, or as destination therapy. Full median sternotomy or minimally invasive techniques are the more standard approaches used at present.  LVADs are usually implanted between the left ventricle apex and the ascending aorta. An implantation through a left thoracotomy with an outflow graft connected to the descending aorta is much less performed nowadays due to the longer times to extubation, higher incidence of postoperative pain, and poorer hemodynamics in the ascending aorta, which may lead to thrombosis...
April 25, 2018: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://www.readbyqxmd.com/read/29747638/relations-of-lipid-parameters-other-variables-with-carotid-intima-media-thickness-and-plaque-in-the-general-chinese-adults-an-observational-study
#8
Qingtao Hou, Sheyu Li, Yun Gao, Haoming Tian
BACKGROUND: It has been reported that non-high-density lipoprotein cholesterol (non-HDL-C) and lipid ratios, including total cholesterol (TC) / high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) / HDL-C, are better predictors for atherosclerosis than conventional lipid profiles. However, there have been few studies comparing the predictive values of different lipid parameters for early atherosclerosis. The aim of this study was to determine the relevant factors of carotid intima-media thickness (IMT) and plaque in the general Chinese adults and analyze the predictive values of different lipid parameters for carotid IMT and plaque...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29746257/novel-pharmacotherapy-in-hypertrophic-cardiomyopathy
#9
Gabriela Andries, Srikanth Yandrapalli, Srihari S Naidu, Julio A Panza
Hypertrophic cardiomyopathy (HCM) is an inherited disease characterized by unexplained left ventricular hypertrophy. Although it is estimated to affect 1 out of 500 people, the HCM gene carrier prevalence is much more common, probably as high as 1 in 200 people. Most affected individuals have a normal life expectancy, while some patients may develop sudden cardiac death or end-stage heart failure. Despite significant developments in the treatment of HCM with surgical, interventional, and device-based procedures, the main focus of current pharmacological therapy has not evolved from the basic objectives of relief of symptoms and improvement in functional capacity...
May 9, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29734258/red-cell-distribution-width-predicts-90-day-mortality-in-continuous-flow-left-ventricular-assist-device-patients
#10
Lauren K Truby, Lakshmi Sridharan, Raul J Flores, A Reshad Garan, Douglas Jennings, Melana Yuzefpolskaya, Koji Takeda, Hiroo Takayama, Yoshifumi Naka, Paolo C Colombo, Veli K Topkara
Red cell distribution width (RDW) measures the variance in size of circulating red blood cells and is a strong independent predictor of morbidity and mortality in cardiovascular disease and heart failure. Predictive power of RDW on mortality after continuous-flow left ventricular assist device (CF-LVAD) implantation remains largely unknown. Four hundred nine patients who underwent CF-LVAD implantation between April 2004 and December 2015 were retrospectively analyzed. The primary outcome of interest was 90 day mortality after CF-LVAD implantation...
April 19, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29731387/challenges-of-immunosuppressive-and-antitrypanosomal-drug-therapy-after-heart-transplantation-in-patients-with-chronic-chagas-disease-a-systematic-review-of-clinical-recommendations
#11
REVIEW
Silas Santana Nogueira, Amanda Aparecida Felizardo, Ivo Santana Caldas, Reggiani Vilela Gonçalves, Rômulo Dias Novaes
BACKGROUND: Although contraindicated for decades, heart transplantation (HT) has finally become a feasible therapeutic option for the treatment of Chagasic patients with end-stage heart failure. Part of the success in achieving acceptable survival rates after HT is due to the enhancement of the pharmacological management of allograft rejection and reactivation of Trypanosoma cruzi infection. METHODS: By using the framework of a systematic review, we investigated if Chagasic patients who have undergone a HT are treated with similar immunosuppressive and antitrypanosomal regimens in endemic and non-endemic countries and exhibits similar T...
April 17, 2018: Transplantation Reviews
https://www.readbyqxmd.com/read/29731076/application-of-the-revised-cardiac-risk-index-to-the-model-for-end-stage-liver-disease-score-improves-the-prediction-of-cardiac-events-in-patients-undergoing-liver-transplantation
#12
Y-S Park, Y-J Moon, I-G Jun, J-G Song, G-S Hwang
INTRODUCTION: Although the revised cardiac risk index (RCRI) is a useful tool for estimating the risk of postoperative cardiac events, whether it improves the prediction of cardiac events in patients undergoing liver transplantation (LT) has not been sufficiently demonstrated. METHODS: We retrospectively analyzed 1429 patients who underwent LT. Cardiac events were defined as myocardial infarction, death, or combined events within 30 days after surgery. The RCRI was defined as the number of independent predictors including high-risk surgery, ischemic heart disease, congestive heart failure, cerebrovascular disease, insulin treatment, and creatinine level >2 mg/dL...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29731073/pretransplantation-cystatin-c-but-not-creatinine-predicts-30-day-cardiovascular-events-and-mortality-in-liver-transplant-recipients-with-normal-serum-creatinine-levels
#13
H-M Kwon, Y-J Moon, K-W Jung, I-G Jun, J-G Song, G-S Hwang
BACKGROUND: The connection between renal dysfunction and cardiovascular dysfunction has been consistently shown. In patients with liver cirrhosis, renal dysfunction shows a tight correlation with prognosis after liver transplantation (LT); therefore, precise renal assessment is mandatory. Cystatin C, a sensitive biomarker for assessing renal function, has shown superiority in detecting mild renal dysfunction compared to classical biomarker creatinine. In this study, we aimed to compare cystatin C and creatinine in predicting 30-day major cardiovascular events (MACE) and all-cause mortality in LT recipients with normal serum creatinine levels...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29723531/transplant-outcomes-for-congenital-heart-disease-patients-bridged-with-a-ventricular-assist-device
#14
Roosevelt Bryant, Raheel Rizwan, Chet R Villa, Farhan Zafar, Dennis Wells, Clifford Chin, Angela Lorts, David L Morales
BACKGROUND: Ventricular assist device (VAD) use as a bridge-to-transplant (BTT) for children with end-stage heart failure and congenital heart disease (CHD), although challenging, has increased but its impact on post-transplant outcome is unknown. This study describes post-transplant outcomes of CHD patients BTT with a VAD. METHODS: All heart transplants identified in UNOS database from 2006-2015 (N=21,865) were divided into four groups based on the diagnosis of CHD and VAD support at transplant: +CHD/+VAD, +CHD/-VAD, +VAD/-CHD and -VAD/-CHD...
April 30, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29718077/the-role-of-neuropsychology-on-organ-transplant-teams
#15
Deborah D Roman
Neuropsychological evaluations have been a required component of heart transplant workups at the University of Minnesota Medical Center since 1989. Since end stage kidney, liver, pancreas, and lung disease commonly effects cognition, our service now regularly consults on those transplant teams as well. This article details the role of neuropsychology in a large transplant center, outlining the requisite training and skills needed to serve these patient populations. While transplant is restricted to major medical centers, patients with end stage organ failure are plentiful and can benefit from neuropsychological expertise, providing a substantial source of clinical expansion and research study for our profession...
May 1, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29717556/heart-failure-and-sudden-cardiac-death-in-heritable-thoracic-aortic-disease-caused-by-pathogenic-variants-in-the-smad3-gene
#16
Julie De Backer, Alan C Braverman
BACKGROUND: Predominant cardiovascular manifestations in the spectrum of Heritable Thoracic Aortic Disease include by default aortic root aneurysms- and dissections, which may be associated with aortic valve disease. Mitral- and tricuspid valve prolapse are other commonly recognized features. Myocardial disease, characterized by heart failure and/or malignant arrhythmias has been reported in humans and in animal models harboring pathogenic variants in the Fibrillin1 gene. METHODS: Description of clinical history of three cases from one family in Ghent (Belgium) and one family in St...
May 1, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29713851/assessment-of-complementary-treatment-with-yiqi-fumai-lyophilized-injection-on-acute-decompensated-ischemic-heart-failure-act-adihf-rationale-and-design-of-a-multicenter-randomized-controlled-trial
#17
Xianliang Wang, Zhiqiang Zhao, Yazhu Hou, E Tang, Guoyuan Zhao, Shuai Wang, Yingfei Bi, Chengliang Zhong, Ming Ren, Junhua Zhang, Jingyuan Mao, Boli Zhang
BACKGROUND: Heart failure (HF) is the end stage of many heart diseases, and ischemic heart disease (IHD) is the primary cause. Yiqi Fumai lyophilized injection, a contemporary Chinese medicine preparation, widely used in the treatment of IHF patients, shows clinical efficacy on improving symptoms and cardiac function, but the quality of the current literature does not address multiple important issues. This article describes a protocol for assessment of complementary treatment with Yiqi Fumai lyophilized injection in acute decompensated IHD...
April 30, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29710092/evolution-of-left-ventricular-assist-device-therapy-for-advanced-heart-failure-a-review
#18
Leslie W Miller, Joseph G Rogers
Importance: The mortality rate for the most advanced forms of heart failure with medical therapy alone remains unacceptably high at 30% to 80% at 1 year. In the past decade, left ventricular assist devices have assumed an increasingly prominent role in the management of these patients. This review included all English-language articles published over the past 15 years on left ventricular assist devices. Search topics focused on advanced heart failure and ventricular assist devices, including volume of implantations, patient selection, complications, cost, and recovery of function...
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29707413/end-stage-renal-failure-is-an-independent-risk-factor-for-1-year-mortality-after-hip-fracture-surgery
#19
Louise Woon Theng Lo, Xu Yanling, Andrew Chia Chen Chou, Tet Sen Howe, John Carson Allen, Joyce Suang Bee Koh
Introduction: End-stage renal failure (ESRF) with its associated comorbidities increase postoperative mortality in hip fracture patients. This study investigated the association of ESRF with various comorbidities in patients on dialysis and assessed rates ESRF as an independent risk factor for all-cause postoperative 1- year mortality rates. Methods: This was a retrospective cohort study on patients aged 55 years and older who underwent their first nonpathological, low-energy hip fracture surgery at an Asian tertiary hospital from June 2007 to 2012...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29707076/clinical-predictors-for-repeat-hospitalizations-in-left-ventricular-assist-device-lvad-patients-with-gastrointestinal-bleeding
#20
Charles V Welden, Wiley Truss, Gerald McGwin, Frederick Weber, Shajan Peter
Background: Patients implanted with left ventricular assist devices (LVAD) carry an increased risk of gastrointestinal bleeding (GIB), estimated at 25% in most studies. Significant efforts are employed in localizing and stopping the source of bleeding, but the rates of repeat hospitalization for GIB remain surprisingly high. Given the increasing incidence of LVAD-dependent end-stage heart failure and the excessive costs associated with repetitive endoscopic investigations, risk factors associated with re-bleeding need to be determined...
April 2018: Gastroenterology Research
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