R S Laskar, C Qu, J R Huyghe, T Harrison, R B Hayes, Y Cao, P T Campbell, R Steinfelder, F R Talukdar, H Brenner, S Ogino, S Brendt, D T Bishop, D D Buchanan, A T Chan, M Cotterchio, S B Gruber, A Gsur, B van Guelpen, M A Jenkins, T O Keku, B M Lynch, L Le Marchand, R M Martin, K McCarthy, V Moreno, R Pearlman, M Song, K K Tsilidis, P Vodička, M O Woods, K Wu, L Hsu, M J Gunter, U Peters, N Murphy
BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. Colorectal cancer (CRC) has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian randomization analyses to explore germline genetic and causal modifiable risk factors associated with EOCRC...
February 24, 2024: Annals of Oncology: Official Journal of the European Society for Medical Oncology