Joshua Gardner, Sean Hammond, Rebecca Jensen, Andrew Gibson, Matthew S Krantz, Michael Ardern-Jones, Elizabeth J Phillips, Munir Pirmohamed, Amy E Chadwick, Catherine Betts, Dean J Naisbitt
BACKGROUND: Vancomycin, a glycopeptide antibiotic used for Gram-positive bacterial infections, has been linked with drug reaction with eosinophilia and systemic symptoms (DRESS) in HLA-A*32:01-expressing individuals. This is associated with activation of T lymphocytes, for which glycolysis has been isolated as a fuel pathway following antigenic stimulation. However, the metabolic processes that underpin drug-reactive T-cell activation are currently undefined and may shed light on the energetic conditions needed for the elicitation of drug hypersensitivity or tolerogenic pathways...
January 4, 2024: Clinical and Experimental Allergy