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"Drug reaction with eosinophilia and systemic symptoms"

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https://www.readbyqxmd.com/read/28758263/anti-epileptic-drugs-induce-cutaneous-lymphocyte-associated-antigen-down-regulation-leading-to-potential-human-herpes-virus-7-reactivation-in-clinically-asymptomatic-patients
#1
F Caillot, E Andrieu, E Houivet, S Duvert-Lehembre, S Calbo, B Sabbah, D Maltete, O Martinaud, F Le Goff, P Malekpour, M Berard, S Rogez, P Joly, D Picard, P Musette
Anti-epileptic drugs (AED) are known to cause cutaneous adverse drug-induced reactions. The pathogenesis of these drug-induced reactions remains poorly understood. In our previous multicenter prospective study, we evidenced reactivation of Epstein-Barr Virus (EBV), Human Herpes Virus 6 (HHV-6) and/or Human Herpes Virus 7 (HHV-7) in 76% of Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) patients. As a consequence of this increased viral antigen exposure, EBV-specific CD8+ T lymphocytes that expressed high levels of Cutaneous Lymphocyte-associated Antigen (CLA) homing markers of skin were found both in blood and in involved organs including skin...
July 31, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28752124/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-successfully-treated-with-tumor-necrosis-factor-%C3%AE-inhibitor
#2
Ryan Edrick Leman, Lingling Chen, Xin Shi, Sarah Patricia Rolimpandoei, Xin Ling, Yuhua Su
No abstract text is available yet for this article.
July 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28748902/acute-renal-failure-secondary-to-drug-related-crystalluria-and-or-drug-reaction-with-eosinophilia-and-systemic-symptom-syndrome-in-a-patient-with-metastatic-lung-cancer
#3
Saime Paydas, Mustafa Balal, Firat Kocabas, Nurettin Ay
Drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity is a severe adverse drug-induced reaction. Aromatic anticonvulsants, such as phenytoin, phenobarbital, and carbamazepine, and some drugs, can induce DRESS. Atypical crystalluria can be seen in patients treated with amoxycillin or some drugs and can cause acute renal failure. We describe a 66-year-old man who presented fever and rash and acute renal failure three days after starting amoxycillin. He was also using phenytoin because of cerebral metastatic lung cancer...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28733562/incidence-of-cutaneous-adverse-drug-reactions-among-medical-inpatients-of-sultanah-aminah-hospital-johor-bahru
#4
S Latha, S E Choon
INTRODUCTION: Cutaneous adverse drug reactions (cADRs) are common. There are only few studies on the incidence of cADRs in Malaysia. OBJECTIVE: To determine the incidence, clinical features and risk factors of cADRs among hospitalized patients. METHODS: A prospective study was conducted among medical inpatients from July to December 2014. RESULTS: A total of 43 cADRs were seen among 11 017 inpatients, yielding an incidence rate of 0...
June 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28728858/-dress-complicated-by-hemophagocytic-lymphohistiocytosis-in-an-infant-treated-for-congenital-toxoplasmosis
#5
S Rioualen, J Dufau, C Flatres, P Lavenant, L Misery, J-M Roué
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe disease that may be complicated by hemophagocytic lymphohistiocytosis but this is rarely described in children. PATIENTS AND METHODS: We report the case of a 5-week old infant hospitalized in a pediatric intensive care unit for hemophagocytic lymphohistiocytosis with prolonged fever, splenomegaly, cytopenia, fibrinogen≤1.5g/L, ferritin≥500μg/L, and soluble IL-2 receptor≥2400U/mL...
July 17, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28721327/two-catastrophes-in-one-patient-drug-reaction-with-eosinophilia-and-systemic-symptoms-and-toxic-shock-syndrome
#6
Moayed Ibrahim, Diana L Nunley
A 70-year-old, immunocompromised patient presented to the emergency room (ER) five weeks after she was started on clopidogrel. She complained of skin eruption, mouth ulcers, fatigue, and myalgia over the past two weeks. Labs showed severe hyponatremia, acute kidney injury, rhabdomyolysis, hyperkalemia, and elevated liver enzymes. She was treated with steroids and discharged after her condition improved. However, a month later, she returned to the ER, complaining of nausea, vomiting, diarrhea, dizziness, chills, and shortness of breath over the past two days...
June 15, 2017: Curēus
https://www.readbyqxmd.com/read/28718873/clinical-features-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-a-study-of-25-patients-in-korea
#7
Jin Y Lee, Suh-Young Lee, Ji E Hahm, Jae W Ha, Chul W Kim, Sang S Kim
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare adverse drug reaction. This study aimed to evaluate the incidence of association with individual drugs, clinical manifestations, disease course, and outcomes of DRESS. METHODS: Using the criteria of the European Registry of Severe Cutaneous Adverse Reactions (RegiSCAR), the medical records of 25 patients diagnosed with DRESS between 2006 and 2015 were retrospectively reviewed...
July 18, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28684647/hypersensitivity-to-antipyretics-pathogenesis-diagnosis-and-management
#8
REVIEW
Q U Lee
Antipyretics are commonly prescribed drugs and hypersensitivity occurs at rates of 0.01% to 0.3%. Hypersensitivity can be due to immune mechanisms that include type I to IV hypersensitivity. Type I hypersensitivity results from specific immunoglobulin E production following sensitisation on first exposure. Subsequent exposures elicit degranulation of mast cells, culminating an immediate reaction. Non-type I hypersensitivity is a delayed reaction that involves various effector cells, resulting in maculopapular rash, fixed drug eruptions, drug reaction with eosinophilia and systemic symptoms, and Stevens-Johnson syndrome/toxic epidermal necrolysis...
July 7, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28672735/safety-concerns-associated-with-second-generation-antipsychotic-long-acting-injection-treatment-a-systematic-update
#9
Salvatore Gentile
Background It has been recently suggested that second-generation antipsychotic long-acting injection (SGA-LAIs) are underutilized in clinical practice, despite that their costs significantly impact on national health system budgets. Hence, an updated analysis of safety data shown by SGA-LAIs may contribute to clarify their role in clinical practice. Materials and methods English-language, peer-reviewed articles reporting updated, primary findings on the SGA-LAI safety were identified (updated through an electronic search of five databases - PubMed, EMBASE, PsycInfo, DARE and the Cochrane Library)...
June 23, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28669649/-dress-syndrome-and-agranulocytosis-a-rare-combination
#10
P Lavenant, J-M Roue, F Huet, C Abasq, L Misery, S Rioualen
INTRODUCTION: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe toxidermia that can lead to death from multivisceral failure. We report a case of DRESS associated with febrile agranulocytosis in a child. OBSERVATION: An 8-year-old child was hospitalized for diffuse maculopapular exanthema with edema of the extremities and face associated with cheilitis and febrile agranulocytosis. This symptomatology began 1month after the introduction of carbamazepine for partial epilepsy...
June 29, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28665897/dress-syndrome-drug-reaction-with-eosinophilia-and-systemic-symptoms
#11
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28665896/dress-syndrome-drug-reaction-with-eosinophilia-and-systemic-symptoms
#12
Howard M Corneli
DRESS syndrome is a cutaneous and systemic drug reaction with severe complications and a long course that can be fatal. Recognition may be difficult, and the condition is just rare enough that clinicians will eventually see it but may not be familiar with it. This review will focus on key elements to help clinicians with the challenges of recognition and differential diagnosis.
July 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28665895/dress-syndrome-or-hematologic-malignancy-a-case-report-of-a-4-year-old-boy
#13
Gulser Esen Besli, Sema Yildirim, Kutluhan Yilmaz, Elif Yuksel
Drug reaction with eosinophilia and systemic symptom (DRESS) is a serious idiosyncratic drug reaction. It is characterized by skin eruption, fever, hematologic abnormalities, and multi-organ involvement. Diagnosis is challenging because of the wide clinical spectrum. Its association with aromatic antiepileptic drugs, such as phenytoin, phenobarbital, and carbamazepine, has been well described in adults. There are few reports of DRESS syndrome in children, and knowledge about the relationship between new antiepileptic drugs such as oxcarbazepine and this syndrome is limited...
July 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28653374/a-familial-mediterranean-fever-flare-induced-by-a-drug-reaction-with-eosinophilia-and-systemic-symptoms
#14
A Deschamps, A Samain, P Carvalho, P Courville, H Levesque, P Musette, P Joly
Familial Mediterranean Fever (FMF) is an autosomal recessive inherited auto-inflammatory disease revealed by flare episodes characterized by systemic symptoms (pleural, joint serositis, abdominal pain…) that are triggered by infections, cold or menstruations. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe cutaneous adverse reaction characterized by visceral involvement and viral reactivation including HHV6, HHV7, EBV, CMV… and may be associated with certain HLA alleles. This article is protected by copyright...
June 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28638280/anticonvulsant-hypersensitivity-syndrome-after-phenytoin-administration-in-an-adolescent-patient-a-case-report-and-review-of-literature
#15
Malik Ghannam, Shaden Mansour, Aya Nabulsi, Qusay Abdoh
BACKGROUND: Hypersensitivity is a rare adverse drug reaction (ADR) associated with anti-epileptic medications. Phenytoin is one of the commonly used drugs for treatment of epilepsy that encounters a hypersensitivity reaction. This reaction can be ranged from mild cutaneous rash to anticonvulsant hypersensitivity syndrome (AHS) or drug reaction with eosinophilia and systemic symptoms (DRESS) that includes fever, rash, eosinophilia and involvement of multiple internal organs. CASE PRESENTATION: A 15 year old middle eastern female patient from Gaza strip with free past medical and allergic history...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28633581/prediction-and-management-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress
#16
Tetsuo Shiohara, Yoko Kano, Kazuhisa Hirahara, Yumi Aoyama
No abstract text is available yet for this article.
July 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28616438/drug-reaction-with-eosinophilia-and-systemic-symptom-in-a-patient-with-pneumonia-and-hyperthyroidism
#17
Hualiang Jin, Limin Wang, Jian Ye
Drug rash with eosinophilia and systemic symptoms syndrome is an idiosyncratic drug reaction characterized by fever, skin eruption, lymph node enlargement, and internal organ involvement. We report a case of a patient with pneumonia who developed clinical manifestations of fever, rash, lymphadenopathy, hypereosinophilia, and visceral involvement (renal failure and eosinophilic pneumonitis) caused by methimazole. The patient improved remarkably with drug withdrawal. A high index of clinical suspicion is emphasized to facilitate prompt diagnosis of medication-related adverse effect and its discontinuation...
April 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28611628/overlapping-dress-and-stevens-johnson-syndrome-case-report-and-review-of-the-literature
#18
Aneline Casagranda, Mariano Suppa, Florence Dehavay, Véronique Del Marmol
Drug-induced severe cutaneous adverse reactions (SCARs) include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis). The identification of the causal drug is crucial in order to avoid further exposure, but making the right differential diagnosis of the type of SCAR is equally important since treatment, follow-up, and prognosis of different SCARs are not the same. These syndromes are distinct entities with different clinical, biological, and histological patterns, but sometimes the early distinction between 2 SCARs can be extremely challenging, and overlapping conditions could therefore be taken into consideration, although true overlapping SCARs are very rare when using strict diagnostic criteria (described by the RegiSCAR group)...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28611626/angioimmunoblastic-t-cell-lymphoma-mimicking-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome
#19
Joanna Mangana, Emmanuella Guenova, Katrin Kerl, Mirjana Urosevic-Maiwald, Valerie C Amann, Cornelia Bayard, Reinhard Dummer, Lars E French
Angioimmunoblastic T-cell lymphoma (AITCL) is a rare, aggressive lymphoma which derives from follicular helper T cells, commonly affecting the elderly population. It accounts for 2% of all non-Hodgkin lymphomas, with a reported 5-year overall survival rate of less than 30%. Very often, the clinical picture of AITCL encompasses systemic symptoms such as generalized lymphadenopathy, hepatosplenomegaly, skin rash, anemia, and polyclonal hypergammaglobulinemia. Here we report on the case of a female patient who presented with clinical features resembling drug reaction with eosinophilia and systemic symptoms (DRESS syndrome) prior to the definitive diagnosis of AITCL...
January 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28598363/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-an-interplay-among-drugs-viruses-and-immune-system
#20
REVIEW
Yung-Tsu Cho, Che-Wen Yang, Chia-Yu Chu
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe multiorgan hypersensitivity reaction mostly caused by a limited number of eliciting drugs in patients with a genetic predisposition. Patients with DRESS syndrome present with characteristic but variable clinical and pathological features. Reactivation of human herpesviruses (HHV), especially HHV-6, is the hallmark of the disease. Anti-viral immune responses intertwined with drug hypersensitivity make the disease more complicated and protracted...
June 9, 2017: International Journal of Molecular Sciences
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