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https://www.readbyqxmd.com/read/28212536/targeting-the-stress-oncoprotein-ledgf-p75-to-sensitize-chemoresistant-prostate-cancer-cells-to-taxanes
#1
Leslimar Ríos-Colón, Christina K Cajigas-Du Ross, Anamika Basu, Catherine Elix, Ivana Alicea-Polanco, Tino W Sanchez, Vinodh Radhakrishnan, Chien-Shing Chen, Carlos A Casiano
Prostate cancer (PCa) is associated with chronic prostate inflammation resulting in activation of stress and pro-survival pathways that contribute to disease progression and chemoresistance. The stress oncoprotein lens epithelium-derived growth factor p75 (LEDGF/p75), also known as DFS70 autoantigen, promotes cellular survival against environmental stressors, including oxidative stress, radiation, and cytotoxic drugs. Furthermore, LEDGF/p75 overexpression in PCa and other cancers has been associated with features of tumor aggressiveness, including resistance to cell death and chemotherapy...
February 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28210952/two-dechlorinated-chlordecone-derivatives-formed-by-in-situ-chemical-reduction-are-devoid-of-genotoxicity-and-mutagenicity-and-have-lower-proangiogenic-properties-compared-to-the-parent-compound
#2
Samuel Legeay, Pierre-André Billat, Nicolas Clere, Fabrice Nesslany, Sébastien Bristeau, Sébastien Faure, Christophe Mouvet
Chlordecone (CLD) is a chlorinated hydrocarbon insecticide, now classified as a persistent organic pollutant. Several studies have previously reported that chronic exposure to CLD leads to hepatotoxicity, neurotoxicity, raises early child development and pregnancy complications, and increases the risk of liver and prostate cancer. In situ chemical reduction (ISCR) has been identified as a possible way for the remediation of soils contaminated by CLD. In the present study, the objectives were (i) to evaluate the genotoxicity and the mutagenicity of two CLD metabolites formed by ISCR, CLD-5a-hydro, or CLD-5-hydro (5a- or 5- according to CAS nomenclature; CLD-1Cl) and tri-hydroCLD (CLD-3Cl), and (ii) to explore the angiogenic properties of these molecules...
February 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28197671/-rectal-perforation-a%C3%A2-rare-complication-following-radiotherapy
#3
M Binnebösel, A Lambertz, C D Klink, U P Neumann
BACKGROUND: Radiotherapy in the treatment of prostate cancer is well established. Intestinal complications following radiotherapy are divided into acute and chronic toxicity. Chronic complications like perforation and fistula formation to the rectum are rare and difficult to treat. MATERIALS AND METHODS: In case of chronic radiotherapy complications and particularly chronic fistula formation to the rectum, evidence is low. Therefore, an overview of the available literature of surgical therapy strategies is given...
February 14, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28187459/autophagy-deactivation-is-associated-with-severe-prostatic-inflammation-in-patients-with-lower-urinary-tract-symptoms-and-benign-prostatic-hyperplasia
#4
Cosimo De Nunzio, Simona Giglio, Antonella Stoppacciaro, Mauro Gacci, Roberto Cirombella, Emidio Luciani, Andrea Tubaro, Andrea Vecchione
Autophagy is a conserved evolutionary process that allows cells to maintain macromolecular synthesis and energy homeostasis during starvation and stressful conditions. We prospectively evaluated the relationship between autophagy and prostatic inflammation in a series of transurethral prostatic resection samples. Inflammatory infiltrates were defined according to the standardized classification of chronic prostatitis of the National Institute of Health. The inflammatory score (IS score) was calculated. High IS score was defined as ≥7...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28185319/gabapentenoids-in-pain-management-in-urological-chronic-pelvic-pain-syndrome-gabapentin-or-pregabalin
#5
Mayank Mohan Agarwal, Mudelin Elsi Sy
AIMS: To compare efficacy of gabapentin and pregabalin in patients with urological chronic pelvic-pain syndrome (UCPPS). METHODS: Design-retrospective, setting-urology outpatient services of a secondary-care private hospital, inclusion criteria-men 18-50 years, presenting with pelvic pain (lower abdomen, groin, scrotum, perineum, low-back, hip) with or without lower urinary tract symptoms for at least 3 months duration. Hospital database was searched using keywords for neuropathic pain (ICD9-729...
February 10, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28183148/ten-year-incidence-and-prevalence-of-clinically-diagnosed-blepharitis-in-south-korea-a-nationwide-population-based-cohort-study
#6
Tyler Hyungtaek Rim, Min Jae Kang, Moonjung Choi, Kyoung Yul Seo, Sung Soo Kim
IMPORTANCE: Blepharitis is one of the most common conditions. However, no study has yet evaluated the epidemiology by evaluating a large population-based sample. BACKGROUND: To evaluate the incidence and prevalence of clinically diagnosed blepharitis in South Korea. DESIGN: Nationwide population-based study. PARTICIPANTS: We investigated the Korean National Health Insurance Service-National Sample Cohort, a representative 1 million-sample of the Korean population, for patients diagnosed with blepharitis according to the Korean Classification of Diseases...
February 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28181685/effects-of-estrogen-receptor-%C3%AE-stimulation-in-a-rat-model-of-non-bacterial-prostatic-inflammation
#7
Shinsuke Mizoguchi, Kenichi Mori, Zhou Wang, Teresa Liu, Yasuhito Funahashi, Fuminori Sato, Donald B DeFranco, Naoki Yoshimura, Hiromitsu Mimata
BACKGROUND: There is increasing evidence showing that chronic non-bacterial prostatic inflammation is involved in the pathogenesis of benign prostatic hyperplasia (BPH) and male lower urinary tract symptoms (LUTS). It has also been reported that estrogen receptor β (ERβ) could have an immunoprotective role in prostatic tissue. Therefore, we investigated the effect of ERβ-activation on not only prostatic inflammation, but also bladder overactive conditions in a rat model with nonbacterial prostatic inflammation...
February 9, 2017: Prostate
https://www.readbyqxmd.com/read/28181681/appearance-of-high-endothelial-venule-like-vessels-in-benign-prostatic-hyperplasia-is-associated-with-lower-urinary-tract-symptoms
#8
So Inamura, Tomochika Shinagawa, Hitomi Hoshino, Yasuhiro Sakai, Yoshiaki Imamura, Osamu Yokoyama, Motohiro Kobayashi
BACKGROUND: Chronic prostatic inflammation is implicated in the pathogenesis of benign prostatic hyperplasia (BPH)-associated lower urinary tract symptoms (LUTS). Previous studies evaluated the degree of chronic prostatic inflammation based on histological scores, which may contain subjective factors. We previously demonstrated that the number of high endothelial venule (HEV)-like vessels correlates positively with the magnitude of inflammation in chronic inflammatory gastrointestinal diseases...
February 9, 2017: Prostate
https://www.readbyqxmd.com/read/28177907/genetic-variation-of-clock-genes-and-cancer-risk-a-field-synopsis-and-meta-analysis
#9
Clara Benna, Charlotte Helfrich-Förster, Senthilkumar Rajendran, Halenya Monticelli, Pierluigi Pilati, Donato Nitti, Simone Mocellin
BACKGROUND: The number of studies on the association between clock genes' polymorphisms and cancer susceptibility has increased over the last years but the results are often conflicting and no comprehensive overview and quantitative summary of the evidence in this field is available. RESULTS: Literature search identified 27 eligible studies comprising 96756 subjects (cases: 38231) and investigating 687 polymorphisms involving 14 clock genes. Overall, 1025 primary and subgroup meta-analyses on 366 gene variants were performed...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28177203/biology-and-insights-into-the-role-of-cohesin-protease-separase-in-human-malignancies
#10
Nenggang Zhang, Debananda Pati
Separase, an enzyme that resolves sister chromatid cohesion during the metaphase-to-anaphase transition, plays a pivotal role in chromosomal segregation and cell division. Separase protein, encoded by the extra spindle pole bodies like 1 (ESPL1) gene, is overexpressed in numerous human cancers including breast, bone, brain, and prostate. Separase is oncogenic, and its overexpression is sufficient to induce mammary tumours in mice. Either acute or chronic overexpression of separase in mouse mammary glands leads to aneuploidy and tumorigenesis, and inhibition of separase enzymatic activity decreases the growth of human breast tumour xenografts in mice...
February 8, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28166777/associations-between-chronic-comorbidity-and-exacerbation-risk-in-primary-care-patients-with-copd
#11
Janine A M Westerik, Esther I Metting, Job F M van Boven, Waling Tiersma, Janwillem W H Kocks, Tjard R Schermer
BACKGROUND: COPD often coexists with chronic conditions that may influence disease prognosis. We investigated associations between chronic (co)morbidities and exacerbations in primary care COPD patients. METHOD: Retrospective cohort study based on 2012-2013 electronic health records from 179 Dutch general practices. Comorbidities from patients with physician-diagnosed COPD were categorized according to International Classification of Primary Care (ICPC) codes. Chi-squared tests, uni- and multivariable logistic, and Cox regression analyses were used to study associations with exacerbations, defined as oral corticosteroid prescriptions...
February 6, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28160074/parasitism-and-inflammation-in-ear-skin-and-in-genital-tissues-of-symptomatic-and-asymptomatic-male-dogs-with-visceral-leishmaniasis
#12
C G Carvalho Junior, R G Teixeira Neto, V V Lopes, V S Belo, N R Alves, T B de Paula, R I M A Ribeiro, E S Silva
Canine visceral leishmaniasis (CVL) is transmitted through vector, although venereal transmission has been suggested. This study aimed to compare the parasitic loads and inflammatory processes in genital tissues with ear skin from seropositive male dogs. Forty-five seropositive dogs were separated into groups containing symptomatic (n = 23) and asymptomatic (n = 22) animals. The control group (n = 2) healthy animals with seronegative and negative results in direct parasitological test. Samples of ear tip skin, prepuce, glans penis, testis, epididymis, and prostate were collected for evaluation of parasitic load and inflammatory infiltrate...
February 3, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28147707/activity-of-chemokines-in-prostate-and-renal-tumors-and-their-potential-role-as-future-therapeutic-targets
#13
Alessia Cimadamore, Marina Scarpelli, Francesco Piva, Francesco Massari, Silvia Gasparrini, Andrea Doria, Liang Cheng, Antonio Lopez-Beltran, Rodolfo Montironi
Chemokines are a class of low-molecular-weight proteins that induce chemotaxis and are implicated in the modulation of angiogenesis. The imbalance among angiogenic and antiangiogenic chemokines can promote the development of several conditions, including chronic inflammation, dysplastic transformation and cancer. In this review, we describe the activity and clinical significance of chemokines in prostate and renal tumors and provide an update on ongoing studies in this setting.
February 2, 2017: Future Oncology
https://www.readbyqxmd.com/read/28147438/seminal-microbiome-in-men-with-and-without-prostatitis
#14
Reet Mändar, Margus Punab, Paul Korrovits, Silver Türk, Kristo Ausmees, Eleri Lapp, Jens-Konrad Preem, Kristjan Oopkaup, Andres Salumets, Jaak Truu
OBJECTIVES: To profile the seminal microbiome applying next generation sequencing. METHODS: Semen samples of 67 men were involved in the study (21 men with and 46 men without prostatitis). Seminal microbiomes were profiled applying the method that uses combinatorial sequence tags attached to polymerase chain reaction primers that amplify the ribosomal ribonucleic acid V6 region. Amplified polymerase chain reaction products were sequenced using an Illumina paired-end protocol on HiSeq2000 platform...
February 1, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28133892/determinants-of-patient-activation-in-a-community-sample-of-breast-and-prostate-cancer-survivors
#15
Denalee O'Malley, Asa A Dewan, Pamela Ohman-Strickland, Daniel A Gundersen, Suzanne M Miller, Shawna V Hudson
OBJECTIVE: Patient activation is associated with improved outcomes among the chronically ill. This study aims to identify factors associated with patient activation in breast and prostate cancer survivors. METHODS: Cross-sectional data were analyzed from cancer survivors diagnosed with Stage I or II breast and prostate cancers who completed treatment in four community-hospital sites in New Jersey during 2012-2013. Analysis of Variance (ANOVA) were used to identify patient characteristics (demographic and psychosocial), clinical factors, and patient perceptions of care associated with patient activation...
January 30, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28129649/rectal-urinary-toxicity-after-hypofractionated-vs-conventional-radiotherapy-in-low-intermediate-risk-localized-prostate-cancer-systematic-review-and-meta-analysis
#16
Rossella Di Franco, Valentina Borzillo, Vincenzo Ravo, Gianluca Ametrano, Sara Falivene, Fabrizio Cammarota, Sabrina Rossetti, Francesco Jacopo Romano, Carmine D'Aniello, Carla Cavaliere, Gelsomina Iovane, Raffaele Piscitelli, Massimiliano Berretta, Paolo Muto, Gaetano Facchini
PURPOSE: The aim of this review was to compare radiation toxicity in Localized Prostate Cancer (LPC) patients who underwent conventional fractionation (CV), hypofractionated (HYPO) or extreme hypofractionated (eHYPO) radiotherapy. We analyzed the impact of technological innovation on the management of prostate cancer, attempting to make a meta-analysis of randomized trials. METHODS: PubMed database has been explored for studies concerning acute and late urinary/gastrointestinal toxicity in low/intermediate risk LPC patients after receiving radiotherapy...
22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28123062/antagonists-of-growth-hormone-releasing-hormone-inhibit-proliferation-induced-by-inflammation-in-prostatic-epithelial-cells
#17
Petra Popovics, Andrew V Schally, Luis Salgueiro, Krisztina Kovacs, Ferenc G Rick
The etiology of benign prostatic hyperplasia (BPH) is multifactorial, and chronic inflammation plays a pivotal role in its pathogenesis. Growth hormone-releasing hormone (GHRH) is a hypothalamic neuropeptide that has been shown to act as paracrine/autocrine factor in various malignancies including prostate cancer. GHRH and its receptors are expressed in experimental models of BPH, in which antagonists of GHRH suppressed the levels of proinflammatory cytokines and altered the expression of genes related to epithelial-to-mesenchymal transition (EMT)...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28122556/therapeutic-effects-of-qian-yu-decoction-and-its-three-extracts-on-carrageenan-induced-chronic-prostatitis-chronic-pelvic-pain-syndrome-in-rats
#18
Keda Zhang, Xiaobin Zeng, Yonggang Chen, Rong Zhao, Hui Wang, Jinhu Wu
BACKGROUND: Qian-Yu decoction (QYD) is a traditional Chinese medicinal recipe composed of Radix astragali (Astragalus membranaceus (Fisch.) Bunge var. mongholicus (Bunge) P.K. Hsiao, Fabaceae ), Herba epimedii (Epimedium brevicornum Maxim., Berberidaceae), Herba leonuri (Leonurus japonicus Houtt., Lamiaceae), Cortex phellodendri (Phellodendron chinense Schneid., Rutaceae) and Radix achyranthis bidentatae (Achyranthes bidentata Bl., Amaranthaceae). This study aimed to evaluate the therapeutic activity of QYD against carrageenan-induced chronic prostatic/chronic pelvic pain syndrome (CP/CPPS) in rats and further elucidate its effective components...
January 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28120647/detection-of-sexually-transmitted-pathogens-in-patients-with-chronic-prostatitis-chronic-pelvic-pain-a-prospective-clinical-study
#19
Dino Papeš, Miram Pasini, Ana Jerončić, Martina Vargović, Viktor Kotarski, Alemka Markotić, Višnja Škerk
In <10% of patients with prostatitis syndrome, a causative uropathogenic organism can be detected. It has been shown that certain organisms that cause sexually transmitted infections can also cause chronic bacterial prostatitis, which can be hard to diagnose and treat appropriately because prostatic samples obtained by prostatic massage are not routinely tested to detect them. We conducted a clinical study to determine the prevalence of Chlamydia, mycoplasma, and trichomonas infection in 254 patients that were previously diagnosed and treated for chronic prostatitis/chronic pelvic pain syndrome due to negative urethral swab, urine, and prostate samples...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28120441/prevalence-of-lower-urinary-tract-symptoms-among-individuals-aged-50%C3%A2-years-and-over-and-its-effect-on-the-quality-of-life-in-a-semi-rural-area-of-western-turkey
#20
Didem Arslantas, Mehmet E Gokler, Alaettin Unsal, Barbaros Başeskioğlu
OBJECTIVES: The number of individuals with lower urinary tract symptoms (LUTS) is increasing as the average age of the men in the community increases. This study aimed to determine the prevalence of LUTS and to assess the quality of life in men aged 50 years and older in Sivrihisar. METHODS: This cross-sectional study was conducted in men aged over 50 years and included 450 subjects. The quality of life was evaluated using the SF-36 Health-Related Quality of Life Scale and the International Prostate Symptom Score (IPSS) to assess the presence and severity of LUTS...
January 2017: Lower Urinary Tract Symptoms
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