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Chronic prostatitis

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https://www.readbyqxmd.com/read/28526581/a-novel-mouse-model-of-chronic-prostatitis-chronic-pelvic-pain-syndrome-induced-by-immunization-of-special-peptide-fragment-with-aluminum-hydroxide-adjuvant
#1
Farhan Ullah Khan, Awais Ullah Ihsan, Waqas Nawaz, Muhammad Zahid Khan, Mengqi Yang, Gang Wang, Xiaoqian Liao, Lei Han, Xiaohui Zhou
OBJECTIVES: CP/CPPS is a commonly observed distress in male patients. Because of its little-known etiology, no effective therapy has been developed which has promising outcomes. Therefore, there is a need to develop a valid model which can mimic the etiology of CP/CPPS. MATERIALS AND METHODS: Fifty male C57BL/6 mice were randomly and averagely divided into 5 groups of 10 mice each. The control group was injected with 0.9% NaCl solution. Aluminum hydroxide and T2 groups were injected with aluminum hydroxide adjuvant and T2 peptide...
May 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28511371/study-of-serum-total-psa-and-free-psa-as-an-oncological-marker-in-breast-tumour
#2
Elteza Tahjiba Jahir, Runi Devi, Bibhuti Bhushan Borthakur
INTRODUCTION: Breast Cancer (BC) cases are rising alarmingly all over the world and India is not an exception. This rising trend is due to an increased age at first child birth, decreased breast feeding, and the changing lifestyle mostly in urban India. With the advent of more sensitive methodologies and research works in this field, it has been suggested that Prostate Specific Antigen (PSA) plays an important role in the pathogenesis of breast cancer besides other established tumour markers...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28510469/outer-dense-fiber-proteins-bridging-between-male-infertility-and-cancer
#3
Faezeh Azizi, Soudeh Ghafouri-Fard
BACKGROUND: The similarities between gametogenic and carcinogenesis processes have been noted for more than decades. Among prominent similarities between these two processes is expression of a group of antigens, namely cancer-testis antigens in both the testes and various cancer tissues. Outer dense fiber (ODF) proteins are testis-specific proteins localized to sperm tails and involved in sperm motility. METHODS: We performed a computerized search of the MEDLINE/PUBMED databases with keywords "outer dense fiber, ODF, cancer, testis, gametogenesis and infertility"...
May 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28507891/discordance-in-perceived-risk-and-epidemiological-outcomes-of-prostate-cancer-among-african-american-men
#4
LaShanta J Rice, Melanie Jefferson, Vanessa Briggs, Ernestine Delmoor, Jerry C Johnson, Sebastiano Gattoni-Celli, Stephen J Savage, Michael Lilly, Sandip M Prasad, Rick Kittles, Chanita Hughes Halbert
As guidelines for prostate cancer screening have changed from an annual screening recommendation starting at age 50 to discussing the benefits and harms of screening with health care providers, it is necessary to examine other types of factors that are important to prostate cancer screening decisions among African American men. Perceived risk of developing cancer has been shown to predict cancer control behaviors and is lower among African Americans. We characterized perceived risk of developing prostate cancer among African American men from November 2009 to 2011 and evaluated the relationship between prostate cancer risk perceptions and sociodemographic characteristics, health care experiences, and knowledge and exposure to health information about cancer...
September 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28506046/interaction-between-trichomonas-vaginalis-and-the-prostate-epithelium
#5
Jung-Hyun Kim, Ik-Hwan Han, Sang-Su Kim, Soon-Jung Park, Duk-Young Min, Myoung-Hee Ahn, Jae-Sook Ryu
Most men infected with Trichomonas vaginalis are asymptomatic and can remain undiagnosed and untreated. This has been hypothesized to result in chronic persistent prostatic infection. Adhesion of the protozoan organisms to mucosal cells is considered a first and prerequisite step for T. vaginalis infection. Adhesion of T. vaginalis to prostate epithelial cells has not yet been observed; however, there are several reports about inflammation of prostate epithelial cells induced by T. vaginalis. The aim of this study was to investigate whether adhesion and cytotoxicity of T...
April 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28499367/the-effectiveness-of-long-needle-acupuncture-at-acupoints-bl30-and-bl35-for-cp-cpps-a-randomized-controlled-pilot-study
#6
Minjie Zhou, Mingyue Yang, Lei Chen, Chao Yu, Wei Zhang, Jun Ji, Chi Chen, Xueyong Shen, Jian Ying
BACKGROUND: The chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is one of the commonest chronic inflammatory diseases in adult men, for which acupuncture has been used to relieve related symptoms. The present study aimed to evaluate the therapeutic effect of the long-needle acupuncture on CP/CPPS. METHODS: A randomized traditional acupuncture-controlled single blind study was conducted on 77 patients who were randomized into long-needle acupuncture (LA) and traditional acupuncture (TA) groups...
May 12, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28499240/establishment-of-a-rat-model-of-chronic-prostatitis-chronic-pelvic-pain-syndrome-cp-cpps-induced-by-immunization-with-a-novel-peptide-t2
#7
Awais Ullah Ihsan, Farhan Ullah Khan, Waqas Nawaz, Muhammad Zahid Khan, Mengqi Yang, Xiaohui Zhou
BACKGROUND: The exact etiological mechanism of Chronic Prostatitis/chronic pelvic pain syndrome (CP/CPPS) is still unclear however autoimmunity is the most valid theory. We developed a rat model of Chronic Prostatitis/chronic pelvic pain syndrome by using a novel peptide (T2) isolated from TRPM8. This model might be beneficial in elucidating mechanisms involved in the pathogenesis of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS). METHODS: 40 male Sprague-Dawley rats with an average weight of 180-220g were equally distributed into five groups...
May 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28497911/the-clinical-efficacy-of-pollen-extract-and-vitamins-on-chronic-prostatitis-chronic-pelvic-pain-syndrome-is-linked-to-a-decrease-in-the-pro-inflammatory-cytokine-interleukin-8
#8
Tommaso Cai, Paolo Verze, Roberto La Rocca, Alessandro Palmieri, Daniele Tiscione, Lorenzo Giuseppe Luciani, Sandra Mazzoli, Vincenzo Mirone, Gianni Malossini
PURPOSE: We aim to evaluate the efficacy of pollen extract in association with vitamins in patients affected by chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and to evaluate the level of the pro-inflammatory mediators interleukin (IL)-6, IL-8, and IL-10. MATERIALS AND METHODS: Patients diagnosed with CP/CPPS between January and December 2015 were enrolled in this study. Participants were randomly assigned to receive oral capsules of pollen extract and vitamins (group A) or bromelain (group B) for 3 months...
April 30, 2017: World Journal of Men's Health
https://www.readbyqxmd.com/read/28497488/the-common-parasite-toxoplasma-gondii-induces-prostatic-inflammation-and-microglandular-hyperplasia-in-a-mouse-model
#9
Darrelle L Colinot, Tamila Garbuz, Maarten C Bosland, Liang Wang, Susan E Rice, William J Sullivan, Gustavo Arrizabalaga, Travis J Jerde
BACKGROUND: Inflammation is the most prevalent and widespread histological finding in the human prostate, and associates with the development and progression of benign prostatic hyperplasia and prostate cancer. Several factors have been hypothesized to cause inflammation, yet the role each may play in the etiology of prostatic inflammation remains unclear. This study examined the possibility that the common protozoan parasite Toxoplasma gondii induces prostatic inflammation and reactive hyperplasia in a mouse model...
May 12, 2017: Prostate
https://www.readbyqxmd.com/read/28493535/the-mongolian-gerbil-meriones-unguiculatus-as-a-model-for-inflammationpromoted-prostate-carcinogenesis
#10
Amado A Quintar, Bianca F Gonçalves, Sebastião R Taboga, Cristina A Maldonado
One of the recognized issues in prostate cancer research is the lack of animal models allowing the research of pathological, biochemical, and genetic factors in immunocompetent animals. Our research group has successfully employed the gerbil in several studisfor prostate diseases. In the present work, we aimed to analyze the effect of chronic bacterial inflammation on MNU-induced prostate carcinogenesis in gerbils Histopathological assessment of the prostatic complex revealed that treatment combinations with MNU plus testosterone or bacterial infection resulted in a promotion of prostate cancer, with bacterial inflammation being more effective in increasing premalignant and malignant tissular alterations than testosterone in the prostate...
May 11, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28488229/chronic-prostatitis-and-its-detrimental-impact-on-sperm-parameters-a-systematic-review-and-meta-analysis
#11
R A Condorelli, G Ivan Russo, A E Calogero, G Morgia, S La Vignera
PURPOSE: Prostatitis is a very common urogenital disease of the male with prevalence ranging from 2.2 to 9.7% worldwide. Interestingly, some recent evidences have showed a significant association between chronic prostatitis (CP) and male infertility including a detrimental effect on sperm parameters, reduction of zinc concentration on semen sperm and production of anti-semen antibodies (ASAs). The aim of the current meta-analysis was to evaluate the association between CP and alteration of semen parameters...
May 9, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28487844/inflammation-in-prostatic-hyperplasia-and-carcinoma-basic-scientific-approach
#12
REVIEW
Božo Krušlin, Davor Tomas, Tihana Džombeta, Marija Milković-Periša, Monika Ulamec
Chronic inflammation is associated with both benign conditions and cancer. Likewise, inflammatory cells are quite common in benign prostatic hyperplasia (BPH) and prostatic tissue harboring cancer. Triggers that activate inflammatory pathways in the prostate remain a subject of argument and are likely to be multifactorial, some of these being bacterial antigens, different chemical irritations, and metabolic disorders. Acute and chronic inflammation in prostate leads to accumulation of immunocompetent cells, mainly T lymphocytes and macrophages, but also neutrophils, eosinophils, and mast cells, depending on the type of offending agent...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28487295/statin-use-serum-lipids-and-prostate-inflammation-in-men-with-a-negative-prostate-biopsy-results-from-the-reduce-trial
#13
Emma H Allott, Lauren E Howard, Adriana C Vidal, Daniel M Moreira, Ramiro Castro-Santamaria, Gerald L Andriole, Stephen J Freedland
Statin use is associated with lower advanced prostate cancer risk. In addition to cholesterol lowering, statins have systemic anti-inflammatory properties. However, their effect on histologic prostate inflammation is not well understood, particularly among men at increased prostate cancer risk but with a negative prostate biopsy. We examined associations between serum lipid levels, statin use, and histologic prostate inflammation using data from 6,655 men with a negative baseline prostate biopsy in the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial...
May 9, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28483457/in-vitro-and-in-vivo-pharmacology-of-nxt629-a-novel-and-selective-ppar%C3%AE-antagonist
#14
Karin J Stebbins, Alex R Broadhead, Geraldine Cabrera, Lucia D Correa, Davorka Messmer, Richard Bundey, Christopher Baccei, Yalda Bravo, Austin Chen, Nicholas S Stock, Peppi Prasit, Daniel S Lorrain
Peroxisome-proliferator activated receptors (PPAR) are members of the nuclear hormone receptor superfamily which regulate gene transcription. PPARα is a key regulator of lipid homeostasis and a negative regulator of inflammation. Under conditions of metabolic stress such as fasting or glucose deprivation, PPARα is upregulated in order to control gene expression necessary for processing alternate fuel sources (e.g. fatty acid oxidation) and thereby promote maintenance of cell viability. Clinically, PPARα expression is upregulated in diseased tissues such as melanoma, chronic lymphocytic leukemia, ovarian and prostate cancer...
May 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28480339/is-chronic-prostatitis-chronic-pelvic-pain-syndrome-an-infectious-disease-of-the-prostate
#15
EDITORIAL
J Curtis Nickel
No abstract text is available yet for this article.
May 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/28465683/chronic-administration-of-tadalafil-improves-the-symptoms-of-patients-with-amicrobic-magi-an-open-study
#16
Sandro La Vignera, Rosita A Condorelli, Laura M Mongioi, Aldo E Calogero
Aim of this study was to evaluate the effects of pharmacological treatment with Tadalafil 5 mg daily on symptoms and quality of sperm parameters in selected patients with amicrobic MAGI (male accessory gland inflammation). 120 patients with amicrobic MAGI (mean age 27.0 ± 6.0 years) with mild-moderate ED (erectile dysfunction) according to IIEF-5 (International Index of Erectile Function 5 Items) scores underwent pharmacological treatment with Tadalafil 5 mg daily for six months. Before and after treatment these patients were evaluated through IIEF-5, semen analysis (according to WHO Criteria, 2010), SI-MAGI (Structured Interview about Male Accessory Gland Inflammation), and ultrasound evaluation...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28461999/mulitcenter-study-on-antibiotic-prophylaxis-infectious-complications-and-risk-assessment-in-tur-p
#17
Laila Schneidewind, Jennifer Kranz, Daniel Schlager, Dimitri Barski, Sandra Mühlsteadt, Markus Grabbert, Fabian Queissert, Tanja Frank, Alexandre Egon Pelzer
INTRODUCTION: Transurethral resection of the prostate is one of the most frequent urological procedures. Urinary tract infections represent major sequelae, but data about antibiotic prophylaxis in TUR-P are controversial and outdated. MATERIAL AND METHODS: We conducted a retrospective multicentre study of TUR-P in ten German hospitals. Primary endpoints were epidemiological and outcome data of TUR-P. Secondary endpoints were the identification of factors associated with febrile UTIs and sepsis after TUR-P...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28461987/fatigue-depression-and-quality-of-life-in-patients-with-prostatic-diseases
#18
Tobias Engl, Daniela Drescher, Ralf Bickeböller, Ralph Grabhorn
INTRODUCTION: Fatigue and depression are commonly attributed to malignant and chronic benign diseases. However, these phenomena have been little investigated to date in prostatic diseases. Our aim was to compare fatigue and depression in prostate cancer patients treated with Androgen Deprivation Therapy (ADT) and in patients with Lower Urinary Tract Symptoms (LUTS) / Benign Prostatic Syndrome. MATERIAL AND METHODS: 100 patients each with PCa (prostate cancer) and BPS (Benign Prostatic Syndrome) were surveyed using the Brief Fatigue Inventory (BFI), EORTC-QLQ C30 [1], and Beck Depression Inventory (BDI)...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28461787/dosimetric-impact-in-the-dose-volume-histograms-of-rectal-and-vesical-wall-contouring-in-prostate-cancer-imrt-treatments
#19
Laura Gómez, Carlos Andrés, Antonio Ruiz
AIM: The main purpose of this study was to evaluate the differences in dose-volume histograms of IMRT treatments for prostate cancer based on the delineation of the main organs at risk (rectum and bladder) as solid organs or by contouring their wall. BACKGROUND: Rectum and bladder have typically been delineated as solid organs, including the waste material, which, in practice, can lead to an erroneous assessment of the risk of adverse effects. MATERIALS AND METHODS: A retrospective study was made on 25 patients treated with IMRT radiotherapy for prostate adenocarcinoma...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28458879/rare-cause-of-massive-lower-gastrointestinal-bleeding-due-to-primary-isolated-ilio-rectal-fistula
#20
Nuttapon Arpornsujaritkun, Chairat Supsamutchai, Wiwat Thirapanich, Pitichote Hiranyatheb, Namsiri Biadul
Massive lower gastrointestinal from primary isolated ilio-rectal fistula is a rare condition and difficult to diagnosis and emergency surgery for this situation has a high mortality rate. This report describes a successful operation in an 88-year-old man at present with massive lower gastrointestinal hemorrhage from ilio-rectal fistula and hypovolemic shock. Underlying diseases are prostate cancer, hypertension, dyslipidemia, aortic stenosis, mitral valve stenosis and chronic renal disease. Operative treatment is to explore laparotomy with internal iliac artery ligation and rectal resection...
April 2017: Journal of Surgical Case Reports
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