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Chronic prostatitis

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https://www.readbyqxmd.com/read/28322961/galactoglucomannan-rich-hemicellulose-extract-from-norway-spruce-picea-abies-exerts-beneficial-effects-on-chronic-prostatic-inflammation-and-lower-urinary-tract-symptoms-in-vivo
#1
Konkol Yvonne, Vuorikoski Heikki, Tuomela Johanna, Holmbom Bjarne, Bernoulli Jenni
Galactoglucomannan (GGM) is the main hemicellulose class in wood of coniferous trees and could be potentially utilized as a possible health-promoting substance for food and pharmaceutical industry. Our aim was to evaluate effects of orally administered GGM-rich extract from Norway spruce in a rat model of chronic prostatitis associated with lower urinary tract symptoms (LUTS). Prostatic inflammation and LUTS was induced in male rats using testosterone and 17β-estradiol exposure for 18 weeks. Rats were treated with 2% GGM dissolved in drinking water during weeks 13-18...
March 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28300967/burden-of-cancer-mortality-and-differences-attributable-to-demographic-aging-and-risk-factors-in-argentina-1986-2011
#2
Sonia Alejandra Pou, Natalia Tumas, Julia Becaria Coquet, Camila Niclis, María Dolores Román, María Del Pilar Díaz
The world faces an aging population that implies a large number of people affected with chronic diseases. Argentina has reached an advanced stage of demographic transition and presents a comparatively high rate of cancer mortality within Latin America. The objectives of this study were to examine cancer mortality trends in the province of Córdoba, Argentina, between 1986 and 2011, and to analyze the differences attributable to risk variations and demographic changes. Longitudinal series of age-standardized mortality rates for overall, breast and prostate cancers were modeled by Joinpoint regression to estimate the annual percent change...
March 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28285755/-the-human-and-economic-burden-of-cancer-in-france-in-2014-based-on-the-sniiram-national-database
#3
Philippe Tuppin, Laurence Pestel, Solène Samson, Anne Cuerq, Sébastien Rivière, Stéphane Tala, Pierre Denis, Jérôme Drouin, Claude Gissot, Christelle Gastaldi-Ménager, Anne Fagot-Campagna
INTRODUCTION: The national health insurance information system (Sniiram) can be used to estimate the national medical and economic burden of cancer. This study reports the annual rates, characteristics and expenditure of people reimbursed for cancer. METHODS: Among 57 million general health scheme beneficiaries (86% of the French population), people managed for cancer were identified using algorithms based on hospital diagnoses and full refund for long-term cancer...
March 9, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28280964/evaluation-of-the-protective-effect-of-pentoxifylline-on-carrageenan-induced-chronic-non-bacterial-prostatitis-in-rats
#4
Mahboobeh Hajighorbani, Mahmood Ahmadi-Hamedani, Elaheh Shahab, Farzad Hayati, Khatereh Kafshdoozan, Keivan Keramati, Amin Hossein Amini
Chronic non-bacterial prostatitis (CNP) is the most common type of prostatitis and oxidative stress (OS) was shown to be highly elevated in prostatitis patients. This study aimed to investigate the protective effect of pentoxifylline (PTX) on CNP induced by carrageenan in rats. Male adult Wistar rats (n = 30) were divided into control, CNP and three treatment groups (n = 6) including CNP + cernilton and CNP + PTX groups. CNP was induced by single intraprostatic injection of 1% carrageenan (100 µl)...
March 9, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28279996/incidence-and-relative-risk-for-developing-cancer-among-patients-with-copd-a-nationwide-cohort-study-in-taiwan
#5
Chung-Han Ho, Yi-Chen Chen, Jhi-Joung Wang, Kuang-Ming Liao
OBJECTIVES: This observational study aimed to examine the incidence of malignant diseases, including specific cancer types, after the diagnosis of chronic obstructive pulmonary disease (COPD) in Taiwanese patients. SETTING: Taiwan's National Health Insurance Research Database. PARTICIPANTS: The definition of a patient with COPD was a patient with a discharge diagnosis of COPD or at least 3 ambulatory visits for COPD. The index date was the date of the first COPD diagnosis...
March 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28272671/hodgkin-lymphoma-in-a-case-of-chronic-myeloid-leukemia-treated-with-tyrosine-kinase-inhibitors
#6
Smeeta Gajendra, Archana Sharma, Rashi Sharma, Sunil Kumar Gupta, Nitin Sood, Ritesh Sachdev
Chronic myeloid leukemia (CML) is characterized by increased and unregulated proliferation of granulocytic lineage in the bone marrow and presence of these immature myeloid cells in the peripheral blood with presence of Philadelphia (Ph) chromosome. Tyrosine kinase inhibitors are the most important drugs in the CML therapy and provide long disease-free survival. Due to the increased survival of CML patients with continual administration of these drugs, the chance of development of secondary malignancies may increase...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28272220/clinical-study-of-duloxetine-hydrochloride-combined-with-doxazosin-for-the-treatment-of-pain-disorder-in-chronic-prostatitis-chronic-pelvic-pain-syndrome-an-observational-study
#7
Mingxin Zhang, Hanzhong Li, Zhigang Ji, Dexin Dong, Su Yan
To explore the safety and efficacy of the selective 5-serotonin and norepinephrine reuptake inhibitor duloxetine hydrochloride and alpha-adrenergic receptor blocker (alpha-blocker) doxazosin mesylate-controlled tablets in the treatment of pain disorder in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).In all, 150 patients were enrolled and 126 patients completed the study (41 patients in the doxazosin group, 41 patients in the sertraline group, and 44 patients in the duloxetine group). This was an open randomized 6-month study...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28270291/feasibility-study-of-low-dose-prostate-ct-perfusion-on-third-generation-dual-source-ct
#8
Gumuyang Zhang, Hao Sun, Huadan Xue, Yun Wang, Jixiang Liang, Kai Xu, Ming Wang, Man Wang, Zhengyu Jin
Objective To investigate the feasibility of using low-dose prostate CT perfusion (pCTP)on a third-generation dual-source CT. Methods Nine patients with elevated prostate-specific antigen underwent pCTP before having prostate biopsy. We measured the blood flow (BF),blood volume (BV),mean transit time (MTT),permeability surface (PS),and time to peak(TTP)of both lesions and normal prostate tissue. The effective dose (ED)was calculated. Results Of the 9 cases,6 were prostate cancers and 3 were prostate hyperplasia with chronic inflammation...
February 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28261375/parental-high-fat-diet-promotes-inflammatory-and-senescence-related-changes-in-prostate
#9
Kulbhushan Tikoo, Ajit Vikram, Shweta Shrivastava, Gopabandhu Jena, Heta Shah, Richa Chhabra
Background. Obesity and dietary habits are associated with increased incidences of aging-related prostatic diseases. The present study was aimed to investigate transgenerational effects of chronic high-fat diet (HFD) feeding on inflammation and senescence-related changes in prostate. Methods. Sprague-Dawley rats were kept on either normal or HFD one. Senescence-associated β-galactosidase (SA β-gal) activity, inflammation, and cellular proliferation were determined in the prostate. Results. Increased SA β-gal activity, expression of p53, and cell proliferation marker PCNA were observed in ventral prostate of HFD-fed rats...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28254462/fatty-acid-amide-hydrolase-inhibitor-treatment-in-men-with-chronic-prostatitis-chronic-pelvic-pain-syndrome-an-adaptive-double-blind-randomized-controlled-trial
#10
Florian M E Wagenlehner, J W Olivier van Till, Jos G A Houbiers, Reynaldo V Martina, Dirk P Cerneus, Joost H J M Melis, Antoni Majek, Egils Vjaters, Michael Urban, Henrikas Ramonas, Daniel A Shoskes, J Curtis Nickel
OBJECTIVE: To examine the effect of a peripherally active fatty acid amide hydrolase (FAAH) inhibitor ASP3652 on safety and efficacy outcomes in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Inhibition of FAAH is hypothesized to reduce the excitability of urinary tract afferents including nociceptors. MATERIALS AND METHODS: In this adaptive, randomized, double-blind, placebo-controlled study, adult male patients with moderate to severe CP/CPPS were treated for 12 weeks with an oral dose of ASP3652 (25, 75, 150, or 300 mg twice daily, or 300 mg once daily), or placebo...
February 27, 2017: Urology
https://www.readbyqxmd.com/read/28252237/neurobiological-and-psychological-evidence-of-chronic-stress-in-prostate-cancer-patients
#11
C F Sharpley, D R H Christie, V Bitsika, L L Agnew, N M Andronicos, M E McMillan, T M Richards
To measure the prevalence and severity of Generalised Anxiety Disorder (GAD), hypo- and hypercortisolaemia, and their association in a sample of prostate cancer (PCa) patients, 97 Australian PCa patients completed a background questionnaire and the GAD-7, and provided a sample of saliva collected 30-45 min after waking. The mean GAD7 score was 9.67 (SD = 3.09), and prevalence rates for current anxiety were higher than those reported for non-PCa males of a similar age. Mean salivary cortisol concentrations (30...
March 2, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28252230/chronic-therapy-with-selective-serotonin-reuptake-inhibitors-and-survival-in-newly-diagnosed-cancer-patients
#12
B Boursi, I Lurie, K Haynes, R Mamtani, Y-X Yang
Depression might be associated with shorter disease specific survival. Selective serotonin reuptake inhibitors (SSRIs) were previously reported to increase the risk of certain malignancies. We aimed to evaluate the impact of SSRIs on cancer mortality. Five retrospective cohort studies were conducted in a UK population-representative database that included all individuals with an incident diagnosis of melanoma, breast, prostate lung and colorectal cancer. The primary exposure of interest was continuous use of SSRIs with past use as the comparison reference...
March 2, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28251667/a-comparison-of-the-pharmacokinetics-and-safety-of-enzalutamide-in-subjects-with-hepatic-impairment-and-matched-healthy-subjects
#13
W Krauwinkel, J Noukens, J van Dijk, S Popa, T Ouatas, M de Vries, D Phung, J Gibbons, J Mordenti, L Mateva
WHAT IS KNOWN AND OBJECTIVE: Enzalutamide is an androgen receptor inhibitor approved for treatment of metastatic castration-resistant prostate cancer. Enzalutamide is highly protein bound and eliminated primarily by hepatic metabolism; therefore, it is important to understand whether enzalutamide pharmacokinetics is altered by hepatic impairment. METHODS: Pharmacokinetic data were obtained from two non-randomized, open-label, single-dose, phase 1 studies conducted in patients with mild (Child-Pugh class A, n = 6) or moderate (Child-Pugh class B, n = 8) hepatic impairment (NCT01901133) or severe (Child-Pugh class C, n = 8) hepatic impairment (NCT02138162) and their corresponding matched healthy controls; data from both studies are presented here...
March 1, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28250427/patterns-of-acute-inflammatory-symptoms-prior-to-cancer-diagnosis
#14
Andrea Setiawan, Li Yin, Gert Auer, Kamila Czene, Karin E Smedby, Yudi Pawitan
Although many studies have examined the role of chronic inflammation in cancer development, few studies discuss the patterns of acute inflammation prior to cancer diagnosis. Patients with lung, colorectal, prostate, or breast cancer between 1 July 2006 and 31 December 2009 and their metastatic status at diagnosis were determined through the Swedish Cancer Register. Non-steroidal anti-inflammatory drugs (NSAIDs) use in the year prior to cancer diagnosis was assessed through the Swedish Prescribed Drug Register...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28248044/-ultrasound-physiotherapy-treatment-of-prostatitis
#15
P I Talberg, M I Andryukhin, S E Mazina, A L Nikolaev
PURPOSE OF THE STUDY: Develop a method of treatment of prostatitis based on the use of a standard antibiotic, immunomodulatory therapy, and transrectal ultrasound physiotherapy. MATERIALS AND METHODS: The dynamics of the accumulation of the antibiotic was investigated in male rats. Sonication was performed immediately before the administration of the antibiotic and its accumulation in the process at 10, 20, 40, 60, 80, 100 min after dosing. The clinical study included 138 patients with chronic prostatitis...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28248039/-association-of-lower-urinary-tract-symptoms-and-testosterone-deficiency-in-men-with-type-2-diabetes
#16
M I Kogan, I I Belousov, H S Ibishev, A A Cherniy, I A Khripun, S V Vorobyev, D V Sizjakin
INTRODUCTION AND OBJECTIVES: Type 2 diabetes mellitus, as a chronic systemic metabolic disease, is widely spread in the population of middle- aged men. Previously it has been proven the link between the presence of type 2 diabetes and the development of lower urinary tract symptoms in men. At the same time, middle-aged men are characterized by the appearance and progression of benign prostatic hyperplasia. MATERIAL AND METHODS: We performed a study of middle-aged men with type 2 diabetes to determine the interrelation of micturition disorders with deficiency of serum testosterone, in respect that the pathophysiology of prostatic hyperplasia is regarded as dysmetabolic dyshormonal state...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28248038/-alterations-in-blood-circulation-of-vesicourethral-segment-in-men-with-neurogenic-and-non-neurogenic-lower-urinary-tract-symptoms
#17
Yu G Alayev, Yu M Esilevskiy, T E Shmidt, Yu L Demidko, D N Fiev, K Yu Kazantsev
AIM: To specify the pathogenetic link between blood supply of the bladder neck and lower urinary tract symptoms (LUTS). MATERIAL AND METHODS: The study involved 78 men aged 26 to 50 years, including 19 patients with multiple sclerosis (MS) and LUTS, 29 patients with chronic prostatitis category IIIB with LUTS and 30 patients with chronic prostatitis category IIIB without LUTS (control group). All the patients underwent Doppler ultrasonography of prostatic arteries and selective study of blood flow in the neck of the bladder...
December 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28248018/-diagnosis-and-treatment-of-cystitis-more-questions-than-answers
#18
E V Kulchavenya, S Yu Shevchenko, A G Cherednichenko
INTRODUCTION: Despite the prevalence of acute cystitis, there are still many unsolved problems of diagnosis and treatment of this disease. MATERIAL AND METHODS: To determine the nosological structure of dysuria, 126 female patients who sought medical attention for frequent painful urination were examined. To determine the incidence of outpatient visits to an urologist for patients with cystitis, medical records of 6753 patients of municipal outpatient clinic were analyzed...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247738/-bacterial-prostatitis-and-prostatic-fibrosis-modern-view-on-the-treatment-and-prophylaxis
#19
A V Zaitsev, D Yu Pushkar, L A Khodyreva, A A Dudareva
Treatments of chronic bacterial prostatitis (CP) remain difficult problem. Bacterial prostatitis is a disease entity diagnosed clinically and by evidence of inflammation and infection localized to the prostate. Risk factors for UTI in men include urological interventions, such as transrectal prostate biopsy. Ensuing infections after prostate biopsy, such as UTI and bacterial prostatitis, are increasing due to increasing rates of fluoroquinolone resistance. The increasing global antibiotic resistance also significantly affects management of UTI in men, and therefore calls for alternative strategies...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247733/-metabolic-syndrome-as-a-cause-of-reduced-ejaculate-fertility-in-patients-with-prostatic-tuberculosis
#20
A V Osadchii, E V Kulchavenya
INTRODUCTION: Metabolic syndrome (MS) negatively affects the quality of ejaculate, especially in patients with chronic prostatitis. MATERIAL AND METHODS: To determine the effect of metabolic syndrome on semen parameters in patients with tuberculosis of the prostate (TP), a study of 72 patients with prostatic tuberculosis was conducted. MS was diagnosed when at least three of the five following medical conditions were found: central obesity, elevated levels of plasma triglycerides, high blood pressure, hyperglycemia and decreased levels of high-density lipoproteins...
August 2016: Urologii︠a︡
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