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Negative pressure wound therapy

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https://www.readbyqxmd.com/read/29019537/initial-experience-with-negative-pressure-wound-therapy-with-instillation-in-complex-wounds
#1
Dimas André Milcheski, Marcelo Lima Portocarrero, Daniel Mamere Alvarez, Luiz Guilherme de Moraes Prado Mazuca, Araldo Ayres Monteiro, Rolf Gemperli
OBJECTIVE: to report the initial experience with Negative-Pressure Wound Therapy with instillation in infected or contaminated complex wounds. METHODS: the negative-pressure wound therapy with instillation used was V.A.C. Ulta with Veraflo instillation (Kinetic Concepts, Inc). The mode of operation was continuous with negative pressure set at 125 mmHg for two hours and instillation between the pauses. The instillation time was 20 minutes (contact time of the topical agent with the wound) and the instilled substance was 0...
July 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29016508/prophylactic-negative-pressure-wound-therapy-for-obese-women-after-cesarean-delivery-a-systematic-review-and-meta-analysis
#2
Marcela C Smid, Sarah K Dotters-Katz, Matthew Grace, Sarah T Wright, Margaret S Villers, Abbey Hardy-Fairbanks, David M Stamilio
OBJECTIVE: To summarize available studies on wound complication outcomes after prophylactic negative pressure wound therapy for obese women (body mass index 30 or greater). DATA SOURCES: We conducted a systematic review and meta-analysis using electronic database search (PubMed, Cumulative Index to Nursing and Allied Health Literature, EMBASE, Google scholar, and Web of Science), Cochrane, and trial registries including ClinicalTrials.gov. METHODS OF STUDY SELECTION: We conducted an electronic search of research articles from 1966 to January 2017 for randomized controlled trials (RCTs), prospective cohort, and retrospective cohort studies of negative pressure wound therapy compared with standard dressing after cesarean delivery among obese women...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28992646/first-experiences-with-incisional-negative-pressure-wound-therapy-in-a-high-risk-poststernotomy-patient-population-treated-with-pectoralis-major-muscle-flap-for-deep-sternal-wound-infection
#3
Stefanie Nickl, Johannes Steindl, Daniel Langthaler, Alina Nierlich-Hold, Igor Pona, Wolfgang Hitzl, Alfred Kocher, Wolfgang Happak, Christine Radtke, Chieh-Han Tzou
No abstract text is available yet for this article.
October 9, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/28985633/role-of-negative-pressure-therapy-as-damage-control-in-soft-tissue-reconstruction-for-open-tibial-fractures
#4
Mario Cherubino, Luigi Valdatta, Pierluigi Tos, Salvatore D'Arpa, Luigi Troisi, Pellegatta Igor, Federica Corradi, Umraz Khan
The concept of damage control orthopaedics (DCO) is a strategy that focuses on managing orthopaedic injuries in polytrauma patients who are in an unstable physiological state. The concept of DCO is an extension of damage control surgery or damage limitation surgery (DCS/DLS). Recently, it has become clear that certain patients, following extensive soft tissue trauma, could benefit from the idea of DCS. In the management of severe lower extremity trauma with exposed fracture sites, aggressive early wound excision debridement, early internal fixation, and vascularized wound coverage within a few days after trauma were proposed...
October 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/28976835/use-of-cryopreserved-umbilical-cord-with-negative-pressure-wound-therapy-for-complex-diabetic-ulcers-with-osteomyelitis
#5
A Raphael, J Gonzales
OBJECTIVE: The objective of this study was to evaluate the combined use of cryopreserved human umbilical cord (cUC) allograft and negative pressure wound therapy (NPWT) in treating complex diabetic foot ulcers (DFUs) with bone exposure and osteomyelitis. These types of wound are known to carry a high morbidity and mortality. METHODS: A single-center, retrospective chart review was performed to assess the efficacy of the combined use of cUC with NPWT, by the same surgeon, to help promote the closure of complex DFUs presenting with biopsy-proven osteomyelitis...
October 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28976825/negative-pressure-wound-therapy-versus-gauze-dressings-for-the-treatment-of-contaminated-traumatic-wounds
#6
D Kaushik, Joshi N, R Kumar, Gaba S, R Sapra, K Kumar
OBJECTIVE: This compares hospital suction negative pressure wound therapy (NPWT) with conventional gauze dressings in traumatic soft-tissue injury at a tertiary care centre. METHODS: A prospective control study was conducted between September 2012 and November 2014. Patients with one or more traumatic soft-tissue injuries with contaminated wounds were allocated to either a test group (received NPWT) or control group (received conventional gauze). Wounds were assessed by two orthopaedic surgeons...
October 2, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28966197/reducing-risks-associated-with-negative-pressure-wound-therapy-strategies-for-clinical-practice
#7
Elizabeth Andersson Mattox
Negative-pressure wound therapy represents a relatively new strategy for wound management. Significant, life-threatening complications (bleeding, infection, and retained dressing material) have been associated with negative-pressure wound therapy. As a result, the Food and Drug Administration published several warnings to negative-pressure wound therapy users and recommended that clinicians ordering, managing, and/or monitoring negative-pressure wound therapy be aware of the potential complications and be prepared to take prompt action to reduce patients' risk for harm...
October 2017: Critical Care Nurse
https://www.readbyqxmd.com/read/28964729/-how-do-i-prevent-caesarean-wound-infections-in-obese-patients-in-2017
#8
B Ripamonti, T Raia-Barjat, C Chauleur, P Mathevet
Obesity is an important risk factor of cesarean section and is associated with an increased risk of wound complications such as infections. This review focuses on the available strategies to limit complications in this population. Choice of antiseptic solution, appropriate dose and type of antibiotic prophylaxy, suture closure of subcutaneous fat, suture skin closure and closed incision negative pressure wound therapy may reduce the risk of wound infections associated with cesarean section in obese patients...
September 27, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28951263/prophylactic-negative-pressure-wound-therapy-after-cesarean-is-associated-with-reduced-risk-of-surgical-site-infection-a%C3%A2-systematic-review-and-meta-analysis
#9
REVIEW
Lulu Yu, Ryan J Kronen, Laura E Simon, Carolyn R T Stoll, Graham A Colditz, Methodius G Tuuli
OBJECTIVE: The objective of the study was to assess the effect of prophylactic negative-pressure wound therapy on surgical site infections and other wound complications in women after cesarean delivery. DATA SOURCES: We searched Ovid Medline, Embase, SCOPUS, Cochrane Database of Systematic Reviews, and ClinicalTrials.gov. STUDY ELIGIBILITY CRITERIA: We included randomized controlled trials and observational studies comparing prophylactic negative-pressure wound therapy with standard wound dressing for cesarean delivery...
September 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28944996/negative-pressure-wound-therapy-promotes-muscle-derived-stem-cell-osteogenic-differentiation-through-mapk-pathway
#10
Hong Liu, Xun Zheng, Liang Chen, Chao Jian, Xiang Hu, Yong Zhao, Zonghuan Li, Aixi Yu
Negative pressure wound therapy (NPWT) has been revealed to be effective in the treatment of open fractures, although the underlying mechanism is not clear. This article aimed to investigate the effects of NPWT on muscle-derived stem cell (MDSC) osteoblastic differentiation and the related potential mechanism. The cell proliferation rate was substantially increased in NPWT-treated MDSCs in comparison with a static group for 3 days. There was no observable effect on the apoptosis of MDSC treated with NPWT compared with the control group for 3 days...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28940698/improvement-of-wound-healing-by-regulated-oxygen-enriched-negative-pressure-assisted-wound-therapy-in-a-rabbit-model
#11
Y Z Li, X D Hu, X M Lai, Y F Li, Y Lei
BACKGROUND: Development of drug therapies and other techniques for wound care have resulted in significant improvement of the cure rate and shortening of the healing time for wounds. A modified technique of regulated oxygen-enriched negative pressure-assisted wound therapy (RO-NPT) has been reported. AIM: To evaluate the efficacy and impact of RO-NPT on wound recovery and inflammation. METHODS: Infected wounds were established on 40 adult female white rabbits, which were then randomized to one of four groups: O2 group, regulated negative pressure-assisted wound therapy (RNPT) group, regulated oxygen-enriched negative pressure-assisted wound therapy (RO-NPT) group and healthy control (HC) group...
September 21, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28938387/critical-sized-bone-defects-sequence-and-planning
#12
Paul Toogood, Theodore Miclau
Bone defects associated with open fractures require a careful approach and planning. At initial presentation, an emergent irrigation and debridement is required. Immediate definitive fixation is frequently safe, with the exception of those injuries that normally require staged management or very severe type IIIB and IIIC injuries. Traumatic wounds that can be approximated primarily should be closed at the time of initial presentation. Wounds that cannot be closed should have a negative pressure wound therapy dressing applied...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28933696/a-novel-topical-wound-therapy-delivery-system
#13
Ingrid Herskovitz, Flor E MacQuhae, Luis J Borda, Stephanie Bhagwandin, Juan A Paredes, Thais Polanco, John C Lantis, Paul J Kim, Tania J Phillips, Robert S Kirsner
INTRODUCTION: Wound care dressings have evolved over time, from bandaging to the development of occlusive dressings to negative pressure wound therapy. A novel therapeutic delivery system dressing has been cleared by the United States Food and Drug Administration. This semi occlusive wound dressing has been developed to provide local, continuous delivery of aqueous topical agents, such as therapeutics (anesthetics, antiseptics, antibiotics, steroids, topical beta-blockers, immune modulatory agents, growth factors, and fibrinolytic agents, among others), at a rate of about ¾ mL per day, thus maintaining a hydrated environment and providing topical treatment...
September 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28901717/preliminary-result-with-incisional-negative-pressure-wound-therapy-and-pectoralis-major-muscle-flap-for-median-sternotomy-wound-infection-in-a-high-risk-patient-population
#14
Federico Lo Torto, Ambra Monfrecola, Juste Kaciulyte, Pedro Ciudad, Donato Casella, Diego Ribuffo, Bruno Carlesimo
Deep sternal wound infection (DSWI) represents a dangerous complication that can follow open-heart surgery with median sternotomy access. Muscle flaps, such as monolateral pectoralis major muscle flap (MPMF), represent the main choices for sternal wound coverage and infection control. Negative pressure incision management system has proven to be able to reduce the incidence of these wounds' complications. Prevena(TM) represents one of these incision management systems and we aimed to evaluate its benefits. A total of 78 patients with major risk factors that presented post-sternotomy DSWI following cardiac surgery was selected...
September 13, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28901392/negative-pressure-wound-therapy-regulating-blood-flow-perfusion-and-microvessel-maturation-through-microvascular-pericytes
#15
Zhanjun Ma, Zonghuan Li, Kangquan Shou, Chao Jian, Pengcheng Li, Yahui Niu, Baiwen Qi, Aixi Yu
Negative pressure wound therapy (NPWT) has been demonstrated to accelerate wound healing by promoting angiogenesis. However, whether blood flow perfusion is regulated by microvessel maturation and pericytes following NPWT remains unclear, as well as the exact association between pericytes and collagen type IV. The aim of this study was to investigate the relevant association between blood flow perfusion and microvessel maturation and pericytes following NPWT, and to further explore the underlying molecular mechanisms...
September 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28898538/longitudinal-slit-procedure-combined-with-negative-pressure-wound-therapy-for-exposed-achilles-tendons
#16
Tino Wetzig, Diana Kohn
No abstract text is available yet for this article.
September 12, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28894985/virulence-analysis-of-staphylococcus-aureus-in-a-rabbit-model-of-infected-full-thickness-wound-under-negative-pressure-wound-therapy
#17
Daohong Liu, Zhirui Li, Guoqi Wang, Tongtong Li, Lihai Zhang, Peifu Tang
The aim of this study was to evaluate the virulence of Staphylococcus aureus in a controlled animal study using the standard sterile gauze and negative pressure wound therapy (NPWT), including activation of agr, gene expression and production of virulence foctors and depth of bacterial invasion. The tissue specimens were harvested on days 0 (6 h after bacterial inoculation), 2, 4, 6, and 8 at the center of wound beds. Laser scanning confocal microscopy was performed to obtain bioluminescent images which were used to measure the depth of bacterial invasion...
September 11, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/28885895/meta-analysis-of-comparative-trials-evaluating-a-prophylactic-single-use-negative-pressure-wound-therapy-system-for-the-prevention-of-surgical-site-complications
#18
Vicki Strugala, Robin Martin
BACKGROUND: We report the first meta-analysis on the impact of prophylactic use of a specific design of negative pressure wound therapy (NPWT) device on surgical site complications. METHODS: Articles were identified in which the specific single-use NPWT device (PICO(⋄), Smith & Nephew) was compared with standard care for surgical site infection (SSI), dehiscence, or length of stay (LOS). Risk ratio (RR) ±95% confidence interval (CI) (SSI; dehiscence) or mean difference in LOS ±95% CI was calculated using RevMan v5...
October 2017: Surgical Infections
https://www.readbyqxmd.com/read/28882357/evaluation-of-negative-pressure-wound-therapy-to-closed-laparotomy-incisions-in-acute-care-surgery
#19
Elleson Schurtz, Jerome Differding, Eric Jacobson, Christopher Maki, Mentor Ahmeti
BACKGROUND: Surgical site complications in the form of wound infections are a major burden to the healthcare system. Negative pressure wound therapy (NPWT) as delivered by a surgical incision management system (SIMS) is a novel approach to improve wound healing when applied to closed incisions. However, data is limited in its application to laparotomy incisions in the acute care surgery setting. METHODS: A retrospective case-control study was performed to evaluate the outcomes of SIMS with regard to surgical site infections in a series of 48 consecutive patients in which SIMS was applied to closed laparotomy incisions in the acute care surgery setting...
August 23, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28873059/traction-assisted-internal-negative-pressure-wound-therapy-with-bridging-retention-sutures-to-facilitate-staged-closure-of-high-risk-wounds-under-tension
#20
Michael V DeFazio, James M Economides, Ersilia L Anghel, Ryan K Mathis, John R Barbour, Christopher E Attinger
BACKGROUND/OBJECTIVE: Loss of domain often complicates attempts at delayed wound closure in regions of high tension. Wound temporization with traction-assisted internal negative pressure wound therapy (NPWT), using bridging retention sutures, can minimize the effects of edema and elastic recoil that contribute to progressive tissue retraction over time. The investigators evaluated the safety and efficacy of this technique for complex wound closure. MATERIALS AND METHODS: Between May 2015 and November 2015, 18 consecutive patients underwent staged reconstruction of complex and/or contaminated soft tissue defects utilizing either conventional NPWT or modified NPWT with instillation and continuous dermatotraction via bridging retention sutures...
July 26, 2017: Wounds: a Compendium of Clinical Research and Practice
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