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https://www.readbyqxmd.com/read/29678262/tolfenamic-acid
#1
Sofia Ahmed, Muhammad Ali Sheraz, Iqbal Ahmad
Tolfenamic acid (TA) is a nonsteroidal antiinflammatory drug and belongs to the group of fenamates. It is used as a potent pain reliever in the treatment of acute migraine attacks, and disorders like dysmenorrhea, rheumatoid, and osteoarthritis. TA has shown excellent in vitro antibacterial activity against certain ATCC strains of bacteria when complexed with bismuth(III). It has also been reported to block pathological processes associated with Alzheimer's disease. In the recent past, TA has also been used as a novel anticancer agent for the treatment of various cancers...
2018: Profiles of Drug Substances, Excipients, and related Methodology
https://www.readbyqxmd.com/read/29673289/systematic-review-of-the-pharmacological-agents-that-have-been-tested-against-spreading-depolarizations
#2
Anna Klass, Renan Sánchez-Porras, Edgar Santos
Spreading depolarization (SD) occurs alongside brain injuries and it can lead to neuronal damage. Therefore, pharmacological modulation of SD can constitute a therapeutic approach to reduce its detrimental effects and to improve the clinical outcome of patients. The major objective of this article was to produce a systematic review of all the drugs that have been tested against SD. Of the substances that have been examined, most have been shown to modulate certain SD characteristics. Only a few have succeeded in significantly inhibiting SD...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29671086/the-nrp1-migraine-risk-variant-shows-evidence-of-association-with-menstrual-migraine
#3
Charmaine E Pollock, Heidi G Sutherland, Bridget H Maher, Rodney A Lea, Larisa M Haupt, Alison Frith, E Anne MacGregor, Lyn R Griffiths
BACKGROUND: In 2016, a large meta-analysis brought the number of susceptibility loci for migraine to 38. While sub-type analysis for migraine without aura (MO) and migraine with aura (MA) found some loci showed specificity to MO, the study did not test the loci with respect to other subtypes of migraine. This study aimed to test the hypothesis that single nucleotide polymorphisms (SNPs) robustly associated with migraine are individually or collectively associated with menstrual migraine (MM)...
April 18, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29665696/nosographic-analysis-of-osmophobia-and-field-testing-of-diagnostic-criteria-including-osmophobia
#4
Mona Ameri Chalmer, Thomas Folkmann Hansen, Jes Olesen
Introduction Osmophobia has been suggested as an additional symptom of migraine without aura, and a high prevalence of osmophobia of up to 50% has been reported in the literature. We conducted a nosographic study of osmophobia in all migraineurs and tension-type headache patients and a field testing of suggested diagnostic criteria of osmophobia, presented in the appendix of the second edition of The International Classification of Headache Disorders and suggested by Silva-Néto et al. and Wang et al ., in migraine without aura and tension-type headache patients (n = 1934)...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29661162/the-cold-pressor-test-in-interictal-migraine-patients-different-parasympathetic-pupillary-response-indicates-dysbalance-of-the-cranial-autonomic-nervous-system
#5
Ozan E Eren, Ruth Ruscheweyh, Christoph Schankin, Florian Schöberl, Andreas Straube
BACKGROUND: Data on autonomic nervous system (ANS) activations in migraine patients are quite controversial, with previous studies reporting over- and underactivation of the sympathetic as well as parasympathetic nervous system. In the present study, we explicitly aimed to assess the cranial ANS in migraine patients compared to healthy controls by applying the cold pressor test to a cohort of migraine patients in the interictal phase and measuring the pupillary response. METHODS: In this prospective observational study, a strong sympathetic stimulus was applied to 20 patients with episodic migraine in the interictal phase and 20 matched controls without migraine, whereby each participant dipped the left hand into ice-cold (4 °C) water for a maximum of 5 min (cold pressor test)...
April 16, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29658983/subclinical-vestibular-dysfunction-in-migraineurs-without-vertigo-a-clinical-study
#6
L Bernetti, C Pellegrino, I Corbelli, S Caproni, P Eusebi, M Faralli, G Ricci, P Calabresi, P Sarchielli
OBJECTIVES: This observational study aimed to investigate the presence of potential vestibular system subclinical dysfunction among migraineurs without a history of vertigo and dizziness compared with healthy controls. METHODS: Patients diagnosed with episodic migraine with and without aura were enrolled. All patients and healthy controls underwent vestibular examination using the following conventional tests: sitting position, Pagnini-McClure's, Dix-Hallpike's, head hanging, video head impulse, subjective visual vertical, Romberg, Fukuda, and caloric vestibular stimulation by Fitzgerald-Hallpike's tests...
April 16, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29656928/benign-paroxysmal-migraine-variants-of-infancy-and-childhood-transitions-and-clinical-features
#7
Jacob Brodsky, Karampreet Kaur, Talia Shoshany, Sophie Lipson, Guangwei Zhou
INTRODUCTION: Migraine variant disorders of childhood include benign paroxysmal torticollis of infancy (BPTI) and benign paroxysmal vertigo of childhood (BPVC). This study aimed to review our experience with BPTI and BPVC and determine the incidence of children transitioning between each of these disorders and to vestibular migraine (VM). METHODS: We retrospectively reviewed the medical records of patients seen at the Balance and Vestibular Program at Boston Children's Hospital between January 2012 and December 2016 who were diagnosed with BPTI, BPVC, and/or VM...
March 30, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29651899/caffeine-does-not-affect-susceptibility-to-cortical-spreading-depolarization-in-mice
#8
Nilufer Yalcin, Shih-Pin Chen, Esther S Yu, Tzu-Ting Liu, Jiin-Cherng Yen, Yahya B Atalay, Tao Qin, Furkan Celik, Arn Mjm van den Maagdenberg, Michael A Moskowitz, Cenk Ayata, Katharina Eikermann-Haerter
Several factors that modulate migraine, a common primary headache disorder, also affect susceptibility to cortical spreading depolarization (CSD). CSD is a wave of neuronal and glial depolarization and thought to underlie the migraine aura and possibly headache. Here, we tested whether caffeine, known to alleviate or trigger headache after acute exposure or chronic use/withdrawal, respectively, modulates CSD. We injected C57BL/6J mice with caffeine once (30, 60, or 120 mg/kg; i.p.) ( acute) or twice per day for one or two weeks ( chronic)...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29629048/prophylactic-effect-of-riboflavin-on-pediatric-migraine-a-randomized-double-blind-placebo-controlled-trial
#9
Ahmad Talebian, Babak Soltani, Hamid Reza Banafshe, Gholam Abbas Moosavi, Motahhareh Talebian, Siamak Soltani
Background and aim: Riboflavin may have an acceptable effect on migraine among children. This study was carried out to determine the prophylactic effect of riboflavin on migraine in children. Methods: This randomized clinical trial study was performed at Shahid Beheshti Hospital in Kashan, Iran from December 2012 to February 2015. Ninety children with migraine were allocated randomly into 3 groups (placebo, low-dose and high-dose riboflavin). The outcomes (frequency, intensity and duration of headaches) were measured at baseline and 12 weeks of medication in each group, and the decrease of them were compared...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29623444/polygenic-risk-score-use-in-migraine-research
#10
Mona Ameri Chalmer, Ann-Louise Esserlind, Jes Olesen, Thomas Folkmann Hansen
BACKGROUND: The latest Genome-Wide Association Study identified 38 genetic variants associated with migraine. In this type of studies the significance level is very difficult to achieve (5 × 10- 8 ) due to multiple testing. Thus, the identified variants only explain a small fraction of the genetic risk. It is expected that hundreds of thousands of variants also confer an increased risk but do not reach significance levels. One way to capture this information is by constructing a Polygenic Risk Score...
April 5, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29620580/do-initial-symptom-factor-scores-predict-subsequent-impairment-following-concussion
#11
Paul E Cohen, Alicia Sufrinko, Robert J Elbin, Michael W Collins, Aaron M Sinnott, Anthony P Kontos
OBJECTIVE: Symptom factors present during the first week following concussion may predict subsequent concussion outcomes and recovery duration. We hypothesized that a high loading on cognitive-fatigue-migraine and somatic factors would be predictive of neurocognitive impairment following concussion. We also hypothesized that the affective factor would be related to vestibular symptoms and impairment. DESIGN: Prospective repeated measures. SETTING: Concussion specialty clinic...
March 28, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29619630/is-migraine-primarily-a-metaboloendocrine-disorder
#12
REVIEW
Innocenzo Rainero, Flora Govone, Annalisa Gai, Alessandro Vacca, Elisa Rubino
PURPOSE OF THE REVIEW: The goals of this review are to evaluate recent studies regarding comorbidity between migraine and different metabolic and endocrine disorders and to discuss the role of insulin resistance as a common pathogenetic mechanism of these diseases. RECENT FINDINGS: Recently, several studies showed that migraine is associated with insulin resistance, a condition in which a normal amount of insulin induces a suboptimal physiological response. All the clinical studies that used the oral glucose tolerance test to examine insulin sensitivity found that, after glucose load, there is in migraine patients a significant increase of both plasmatic insulin and glucose concentrations in comparison with controls...
April 4, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29615959/rorschach-evaluation-of-personality-and-emotional-characteristics-in-adolescents-with-migraine-versus-epilepsy-and-controls
#13
Laura Balottin, Stefania Mannarini, Daniela Candeloro, Alda Mita, Matteo Chiappedi, Umberto Balottin
The literature examining primary headache, including migraine, in adolescents, has pointed out the key role played by a wide range of psychiatric disorders in reducing the patients' quality of life. Moreover, pioneering studies showed that preexisting personality characteristics, specific emotion regulation styles and psychological-psychiatric difficulties are likely to increase the risk of the onset, maintenance, and outcome of headache. Still personality issues in migraine have been poorly studied, in particular in children and adolescents...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29610631/the-effect-of-propofol-on-chronic-headaches-in-patients-undergoing-endoscopy
#14
David Giampetro, Victor Ruiz-Velasco, Ashlee Pruett, Matthew Wicklund, Robert Knipe
Objective: This study determined acute and long-term effects of propofol administration in patients with severe headaches undergoing endoscopic procedures. Background: Approximately 13% of the US population is affected by migraines or severe headaches. The effect of propofol on headaches more than a few days after the intervention has not been explored. Methods: We employed a nonrandomized, prospective observational study that recruited patients with chronic headaches who received propofol from an outpatient endoscopy center for either upper or lower endoscopies...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29607917/-cadasil-with-cysteine-sparing-notch3-mutation-manifesting-as-dissociated-progression-between-cognitive-impairment-and-brain-image-findings-in-3-years-a-case-report
#15
Keisuke Tachiyama, Yuji Shiga, Yutaka Shimoe, Ikuko Mizuta, Toshiki Mizuno, Masaru Kuriyama
A 55-year-old man with no history of stroke or migraine presented to the clinic with cognitive impairment and depression that had been experiencing for two years. Neurological examination showed bilateral pyramidal signs, and impairments in cognition and attention. Brain MRI revealed multiple lacunar lesions and microbleeds in the deep cerebral white matter, subcortical regions, and brainstem, as well as diffuse white matter hyperintensities without anterior temporal pole involvement. Cerebral single-photon emission computed tomography (SPECT) revealed bilateral hypoperfusion in the basal ganglia...
March 31, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29601349/factors-associated-with-self-reported-concussion-history-in-middle-school-athletes
#16
Douglas P Terry, Magdalena Wojtowicz, Nathan E Cook, Bruce A Maxwell, Ross Zafonte, Tad Seifert, Noah D Silverberg, Paul D Berkner, Grant L Iverson
OBJECTIVE: Identifying personal characteristics associated with sustaining a concussion is of great interest, yet only a few have examined this in children. The purpose of this study was to examine the association between sex, neurodevelopmental disorders, health history, and lifetime history of self-reported concussion in 12- and 13-year-old athletes. DESIGN: Cross-sectional study. SETTING: Middle schools. PARTICIPANTS: Participants were 1744 twelve- and thirteen-year-old student athletes who completed preseason Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) testing, including a self-report questionnaire about previous concussions, developmental diagnoses, and previous medical treatment...
March 27, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29600549/phenotypes-genotypes-and-the-management-of-paroxysmal-movement-disorders
#17
REVIEW
Laura Silveira-Moriyama, Stjepana Kovac, Manju A Kurian, Henry Houlden, Andrew J Lees, Matthew C Walker, Emmanuel Roze, Alex R Paciorkowski, Jonathan W Mink, Thomas T Warner
As a consequence of the genomic revolution, a large number of publications describing paroxysmal movement disorders have been published in the last few years, shedding light on their molecular pathology. Routine gene testing is not necessary to guide treatment for typical forms of paroxysmal kinesigenic dyskinesia (PKD), paroxysmal nonkinesigenic dyskinesia (PNKD), and episodic ataxia type 1 or 2. It can, however, be helpful in the management of atypical or complex cases, especially for genetic counselling, treatment strategies, and the offer of preimplantation genetic diagnosis...
March 30, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29597079/assessment-of-responsiveness-to-everyday-non-noxious-stimuli-in-pain-free-migraineurs-with-vs-without-aura
#18
Yelena Granovsky, Merav Shor, Alla Shifrin, Elliot Sprecher, David Yarnitsky, Tami Bar-Shalita
Migraineurs with aura (MWA) express higher inter-ictal response to non-noxious and noxious experimental sensory stimuli compared to migraineurs without aura (MWoA), but whether these differences also prevail in response to everyday non-noxious stimuli is not yet explored. This is a cross-sectional study testing fifty-three female migraineurs (30 MWA; 23 MWoA) that underwent wide battery of noxious psychophysical testing at pain-free phase, and completed a sensory responsiveness questionnaire and pain-related psychological questionnaires...
March 26, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29593803/can-we-define-migraine-patients-with-blood-high-sensitivity-c-reactive-protein-and-galectin-3-levels-in-the-emergency-department
#19
Mehtap Gürger, Metin Atescelik, Mustafa Yilmaz, Mustafa Yildiz, Hatice Kalayci, Mehmet Ali Kobat, Caner Fevzi Demir
Introduction: Migraine, the most widespread cause of headache in young adults, is a frequent reason for presentation to emergency departments. The aim of this study was to determine the diagnostic value of serum galectin-3 and high-sensitivity C-reactive protein (hsCRP) levels in migraine patients. Material and methods: Serum galectin-3 and hsCRP levels were measured using enzyme-linked immunosorbent assay in 70 migraine patients and 70 healthy control subjects...
March 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29580567/association-of-depression-anxiety-and-post-traumatic-stress-disorder-with-migraine-data-from-kosovo
#20
Nexhmedin Shala, Shemsedin Dreshaj
INTRODUCTION: Migraine is ranked as the seventh leading cause of disability worldwide, and it is characterized by a manifestation of combined neurological, gastrointestinal, and autonomic symptoms linked with different provoking factors. AIM OF THE STUDY: This study investigates the association between migraine and PTSD, depression and anxiety in the Kosovo population during the post-war period. MATERIAL AND METHODS: 273 war survivors with headache were enrolled in the study and were divided into two groups: 153 individuals with confirmed migraine (the study group) and 120 individuals with non-migraine headaches (control group)...
March 15, 2018: Neurologia i Neurochirurgia Polska
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