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https://www.readbyqxmd.com/read/29453754/pacap38-in-human-models-of-primary-headaches
#1
Håkan Ashina, Song Guo, Anne L H Vollesen, Messoud Ashina
BACKGROUND: To review the role of PACAP38 in human models of primary headaches, discuss possible mechanisms of PACAP38-induced migraine, and outline future directions. DISCUSSION: Experimental studies have established PACAP38 as a potent pharmacological "trigger" molecule of migraine-like attacks. These studies have also revealed a heterogeneous PACAP38 migraine response in migraine without aura patients. In addition, findings from brain imaging studies have demonstrated neuronal and vascular changes in migraine patients both ictally and interictally after PACAP38 infusion...
November 23, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29446070/a-hospital-based-retrospective-study-of-acute-postpartum-headache
#2
Angeliki Vgontzas, Matthew S Robbins
OBJECTIVE: To describe acute headache diagnoses in women presenting emergently in the postpartum period and to determine which factors may be associated with secondary vs primary headache. BACKGROUND: Hormonal, vascular, and procedural factors elevate the risk for both secondary and primary headache disorders in the postpartum period. Differentiating between these can be a diagnostic challenge, particularly among the most severe patients referred for urgent neurological consultation...
February 15, 2018: Headache
https://www.readbyqxmd.com/read/29442286/targeted-orexin-and-hypothalamic-neuropeptides-for-migraine
#3
REVIEW
Lauren C Strother, Anan Srikiatkhachorn, Weera Supronsinchai
The hypothalamus is involved in the regulation of homeostatic mechanisms and migraine-related trigeminal nociception and as such has been hypothesized to play a central role in the migraine syndrome from the earliest stages of the attack. The hypothalamus hosts many key neuropeptide systems that have been postulated to play a role in this pathophysiology. Such neuropeptides include but are not exclusive too orexins, oxytocin, neuropeptide Y, and pituitary adenylate cyclase activating protein, which will be the focus of this review...
February 13, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29438841/anti-migraine-and-anti-depression-activities-of-tianshu-capsule-by-mediating-monoamine-oxidase
#4
Xiaoping Sun, Fangfang Zhu, Jun Zhou, Xiujuan Chang, Liang Li, Hanfei Hu, Zhenzhong Wang, Wei Xiao
BACKGROUND: Tianshu capsule(TSC)is a Chinese patent medicine. It's widely used to treat migraine clinically in China. AIM OF THE STUDY: In the present study, we investigated anti-migraine and anti-depression activities of TSC using in vivo animal models together with in vitro studies to investigate the mechanism of action. MATERIALS AND METHODS: Nitroglycerin (NTG) -induced migraine rat model, rat was given a subcutaneous injection of the NTG suspension (10 mg/kg) once a week for 5 weeks...
February 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29433176/the-decreasing-prevalence-of-the-arcuate-foramen
#5
Juan A Sanchis-Gimeno, Susanna Llido, Marcos Miquel-Feutch, Laura Quiles-Guinau, Luis Rios, Mayte Murillo-Llorente, Marcelino Perez-Bermejo, Shahed Nalla
BACKGROUND: The arcuate foramen (AF), or ponticulus posticus, is an anatomic variant of the first cervical vertebra that consists of a complete or partial osseous bridge over the groove for the vertebral artery and extends from the posterior aspect of the superior articular facet to the superior lateral border of the posterior arch. The AF has been associated with clinical symptoms, such as headache, migraine, neck pain, shoulder pain, arm pain, and vertebral artery dissection. We aimed to test whether the prevalence of the AF has decreased in the modern human population over the past centuries as a result of reduction in inbreeding and endogamy...
February 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29430561/the-cgrp-receptor-antagonist-bibn4096-inhibits-prolonged-meningeal-afferent-activation-evoked-by-brief-local-k-stimulation-but-not-cortical-spreading-depression-induced-afferent-sensitization
#6
Jun Zhao, Dan Levy
Introduction: Cortical spreading depression (CSD) is believed to promote migraine headache by enhancing the activity and mechanosensitivity of trigeminal intracranial meningeal afferents. One putative mechanism underlying this afferent response involves an acute excitation of meningeal afferents by cortical efflux of K + and the ensuing antidromic release of proinflammatory sensory neuropeptides, such as calcitonin gene-related peptide (CGRP). Objectives: We sought to investigate whether (1) a brief meningeal K + stimulus leads to CGRP-dependent enhancement of meningeal afferent responses and (2) CSD-induced meningeal afferent activation and sensitization involve CGRP receptor signaling...
January 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29426682/retrospective-view-of-primary-raynaud-s-phenomenon-in-childhood
#7
Enes Turan, Sara Sebnem Kilic
OBJECTIVES: Primary Raynaud's phenomenon (PRP) manifests as episodes of transient spasms of peripheral blood vessels. To elucidate the clinical clues and laboratory characteristics will facilitate the identification of PRP. METHODS: A retrospective data collection of clinical and laboratory characteristics of 58 children with PRP was performed between January 2007 and December 2016. RESULTS: A positive ANA test at lower titers <1:100 was detected in 24...
February 6, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29425850/neuroprotective-effect-of-da-chuanxiong-formula-against-cognitive-and-motor-deficits-in-a-rat-controlled-cortical-impact-model-of-traumatic-brain-injury
#8
Zhi-Ke Liu, Chun-Fai Ng, Hoi-Ting Shiu, Hing-Lok Wong, Wai-Ching Chin, Jin-Fang Zhang, Ping-Kuen Lam, Wai-Sang Poon, Clara Bik-San Lau, Ping-Chung Leung, Chun-Hay Ko
ETHNOPHARMACOLOGICAL RELEVANCE: Da Chuanxiong Formula (DCXF) is one of the famous herb pairs that contains dried rhizomes of Ligusticum chuanxiong Hort. and Gastrodia elata Bl. in the mass ratio of 4:1. This classic representative traditional Chinese medicine has been widely used to treat brain diseases like headache and migraine caused by blood stasis and wind pathogen. However, the therapeutic effect of DCXF on traumatic brain injury (TBI) has not been reported yet. AIM OF STUDY: The present study was performed to investigate the neuroprotective effects of DCXF and its underlying mechanisms in the controlled cortical impact (CCI)-induced TBI rat model...
February 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29425698/assessment-of-sleep-quantity-and-sleep-disturbances-during-recovery-from-sports-related-concussion-in-youth-athletes
#9
Donna L Murdaugh, Kim E Ono, Andrew Reisner, Thomas G Burns
OBJECTIVE: To determine the relationship between sleep quantity and sleep disturbances on symptoms and neurocognitive ability at the acute phase (<7 days) and post-sports-related concussion (SRC; >21 days). DESIGN: Prospective inception cohort study SETTING: General community setting of regional middle and high schools. PARTICIPANTS: Sample included 528 youth athletes with SRC and 443 controls ages 10-18. MAIN OUTCOME MEASURES: Athletes completed the Immediate Post-Concussive Assessment and Cognitive Testing (ImPACT) battery...
February 6, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29423388/dietary-intake-of-thiamine-in-migraine-patients-and-healthy-subjects-a-case-control-study
#10
Hossein Faraji, Zamzam Paknahad, Ahmad Chitsaz
The migraine headache is a disease related to the neurovascular system, which affects 10%-20% of people, worldwide. Recent evidences suggested a relation between thiamine status and migraine headaches. The current study was undertaken to assess dietary intake of the thiamine in migraine patients and to evaluate its association with the frequency of migraine attacks. In a case-control design, the current study was performed on 50 migraine patients and 50 healthy people, 20-60 years old in Isfahan, Iran, in 2017...
January 2018: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29420786/one-day-behavioral-intervention-for-distressed-veterans-with-migraine-results-of-a-multimethod-pilot-study
#11
C Huddleston, L Martin, K Woods, L Dindo
Introduction: Migraine, a chronic neurological disorder characterized by episodic severe headache pain and functional impairment, affects approximately 12% of the general US population. Veterans returning from Iraq or Afghanistan have two to four times the incidence of migraine of the general population. Veterans with migraines are more than twice as likely to have comorbid psychiatric conditions as veterans without migraines, with depression and post-traumatic stress disorder being most prevalent...
February 6, 2018: Military Medicine
https://www.readbyqxmd.com/read/29414151/migrainous-aura-as-stroke-mimic-the-role-of-perfusion-computed-tomography
#12
Mariana Ridolfi, Antonio Granato, Paola Polverino, Giovanni Furlanis, Maja Ukmar, Irene Zorzenon, Paolo Manganotti
OBJECTIVES: The acute-onset of migrainuos aura (MA) can be erroneously diagnosed in Emergency Department (ED) as acute stroke (AS) and it can be classified as "stroke mimic" (SM). Perfusion computer tomography (PCT) may be useful to improve detection of infarcts. The aim of the study was to investigate the role in ED of PCT in improving diagnosis of migrainous aura. Data were compared with the well-defined perfusion patterns in patients with acute ischemic stroke. PATIENTS AND METHODS: A standardized Stroke Protocol was planned...
January 31, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29413360/a-sixteen-week-three-armed-randomized-controlled-trial-investigating-clinical-and-biochemical-effects-of-targeted-alterations-in-dietary-linoleic-acid-and-n-3-epa-dha-in-adults-with-episodic-migraine-study-protocol
#13
John Douglas Mann, Keturah R Faurot, Beth MacIntosh, Olafur S Palsson, Chirayath M Suchindran, Susan Ann Gaylord, Chanee Lynch, Angela Johnston, Kristen Maiden, David A Barrow, Joseph R Hibbeln, Christopher E Ramsden
Migraine is a prevalent neurological disorder, affecting over 16% of adult women and 7% of adult men in the U.S., causing significant pain, disability, and medical expense, with incomplete benefits from conventional medical management. Migraine, as a chronic pain syndrome, provides a practical model for investigating the impact of dietary modifications in omega-3 (n-3) and omega-6 (n-6) fatty acids. This paper reports the protocol of a trial to assess whether targeted dietary modifications designed to increase n-3 eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with or without concurrent reduction in n-6 linoleic acid (LA), will alter nociceptive lipid mediators and mediate decreases in frequency and severity of migraine...
January 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29411366/case-report-of-the-safety-assessment-of-transcranial-magnetic-stimulation-use-in-a-patient-with-cardiac-pacemaker-to-pulse-or-not-to-pulse
#14
Diana Y Wei, Fiona S Greenwood, Francis D Murgatroyd, Peter J Goadsby
BACKGROUND: Single-pulse transcranial magnetic stimulation (sTMS) is an emerging neuromodulation method reported to be useful in migraine. Despite a low propensity for side effects, some concern with its use in patients with cardiac pacemakers has been expressed. CASE: We present a patient with chronic migraine with a cardiac pacemaker, who had tried unsuccessfully several migraine preventives with either poor efficacy or tolerability. With involvement of the cardiology team, we tested the effect of sTMS on her pacemaker and found it to be a safe and effective option for her...
February 2018: Headache
https://www.readbyqxmd.com/read/29411353/group-education-and-multidisciplinary-management-for-chronic-headaches-among-adolescents-in-a-military-treatment-facility-a-retrospective-chart-review
#15
Andrew Ormond, Brian M Faux, Betty A Zickefoose, James Aden, Patricia E Kapunan, Timothy A Roberts
OBJECTIVE: To assess the effect of group education on the frequency of chronic headaches among adolescents. BACKGROUND: Chronic headaches are a common problem among adolescents with significant psychosocial morbidity. Brief education on lifestyle interventions to decrease headache frequency has established benefits among adult patients but is less proven among adolescents. METHODS: This study is a chart review examining our experience with a group education program for 155 adolescents, aged 12-17 years old, enrolled in the U...
February 7, 2018: Headache
https://www.readbyqxmd.com/read/29406202/diagnosis-and-management-of-headache-in-older-adults
#16
REVIEW
Amaal J Starling
Headache is a common, disabling neurologic problem in all age groups, including older adults. In older adults, headache is most likely a primary disorder, such as tension-type headache or migraine; however, there is a higher risk of secondary causes, such as giant cell arteritis or intracranial lesions, than in younger adults. Thus, based on the headache history, clinical examination, and presence of headache red flags, a focused diagnostic evaluation is recommended, ranging from blood tests to neuroimaging, depending on the headache characteristics...
February 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29404713/long-term-study-of-the-efficacy-and-safety-of-onabotulinumtoxina-for-the-prevention-of-chronic-migraine-compel-study
#17
Andrew M Blumenfeld, Richard J Stark, Marshall C Freeman, Amelia Orejudos, Aubrey Manack Adams
BACKGROUND: OnabotulinumtoxinA is approved for the prevention of headache in those with chronic migraine (CM); however, more clinical data on the risk-benefit profile for treatment beyond one year is desirable. METHODS: The Chronic Migraine OnabotulinuMtoxinA Prolonged Efficacy open Label (COMPEL) Study ( ClinicalTrials.gov , NCT01516892) is an international, multicenter, open-label long-term prospective study. Adults with CM received 155 U of onabotulinumtoxinA (31 sites in a fixed-site, fixed-dose paradigm across 7 head/neck muscles) every 12 weeks (±7 days) for 9 treatment cycles (108 weeks)...
February 5, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29404159/presence-of-headache-and-migraine-in-asthma-patients
#18
Muzaffer Onur Turan, Çiğdem Çelik Susuz, Pakize Ayşe Turan
OBJECTIVES: Migraine is a diseases characterized with severe headaches, with neurological and systemic findings. The purpose of this study is to investigate the prevalence of migraine and to examine whether there is a relationship between atopic disorders, parental history and migraine in asthma patients. MATERIAL AND METHODS: A total of 288 asthma outpatients, who had the diagnosis by an early or late test of reversibility showing a reversible airway obstruction according to hospital database were included...
April 2017: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29397668/the-effects-of-repetitive-transcranial-magnetic-stimulation-at-dorsolateral-prefrontal-cortex-in-the-treatment-of-migraine-comorbid-with-depression-a-retrospective-open-study
#19
Saurabh Kumar, Swarndeep Singh, Nand Kumar, Rohit Verma
Objective: The literature on managing migraine non-responsive to pharmacological approaches and that co-occurring with depression is scanty. The comorbid condition predicts a poorer prognosis for migraine as well as depression. The present report assesses efficacy and tolerability of high frequency repetitive transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex as a treatment modality for migraine with comorbid depression. Methods: The current retrospective chart review assesses effectiveness of high frequency rTMS over left dorsolateral prefrontal cortex as a treatment modality to manage migraine occurring comorbid with depression in 14 subjects...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29396788/cilostazol-induced-migraine-does-not-respond-to-sumatriptan-in-a-double-blind-trial
#20
Katrine Falkenberg, Bára Óladóttir Á Dunga, Song Guo, Messoud Ashina, Jes Olesen
BACKGROUND: Cilostazol is an inhibitor of phosphodiesterase 3 and thus causes accumulation of cAMP. It induces migraine-like attacks in migraine patients. Whether the cilostazol model responds to sumatriptan in migraine patients and therefore is valid for testing of future anti-migraine medications has never been investigated. METHODS: In a cross-over study, 30 patients received cilostazol (200 mg p.o.) on two separate days each day followed by oral self-administered placebo or sumatriptan 50 mg...
February 2, 2018: Journal of Headache and Pain
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