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https://www.readbyqxmd.com/read/28933953/differential-programming-needs-of-college-students-preferring-web-based-versus-in-person-physical-activity-programs
#1
Stephanie P Goldstein, Evan M Forman, Meghan L Butryn, James D Herbert
College students report several barriers to exercise, highlighting a need for university-based programs that address these challenges. In contrast to in-person interventions, several web-based programs have been developed to enhance program engagement by increasing ease of access and lowering the necessary level of commitment to participate. Unfortunately, web-based programs continue to struggle with engagement and less-than-ideal outcomes. One explanation for this discrepancy is that different intervention modalities may attract students with distinctive activity patterns, motivators, barriers, and program needs...
September 21, 2017: Health Communication
https://www.readbyqxmd.com/read/28931386/erratum-to-understanding-how-perceptions-of-tobacco-constituents-and-the-fda-relate-to-effective-and-credible-tobacco-risk-messaging-a-national-phone-survey-of-u-s-adults-2014-2015
#2
Marcella H Boynton, Robert P Agans, J Michael Bowling, Noel T Brewer, Erin L Sutfin, Adam O Goldstein, Seth M Noar, Kurt M Ribisl
No abstract text is available yet for this article.
September 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28931151/global-trends-in-center-accreditation-by-the-joint-commission-international-growing-patient-implications-for-international-medical-and-surgical-care
#3
Ambar Mehta, Seth D Goldstein, Martin A Makary
Millions of patients travel internationally for medical and surgical care. We found that the annual number of centers accredited by the Joint Commission International increased from one center in 1999 to 132 centers in 2016; there are currently 939 accredited centers across 66 countries. Public health and medicolegal implications related to medical travel deserve attention.
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28930778/radioprotection-with-amifostine-enhances-bone-strength-and-regeneration-and-bony-union-in-a-rat-model-of-mandibular-distraction-osteogenesis
#4
Catherine N Tchanque-Fossuo, Alexis Donneys, Sagar S Deshpande, Deniz Sarhaddi, Noah S Nelson, Laura A Monson, Sara E Dahle, Steve A Goldstein, Steven R Buchman
BACKGROUND: Using distraction osteogenesis (DO) to regenerate robust endogenous bone could greatly enhance postoncologic reconstruction of head and neck cancer. However, radiation (XRT) corrosive effects still preclude DO's immense potential. We posit that adjunctive pretreatment with the radioprotectant amifostine (AMF) can optimize wound healing and allow for successful DO with quantifiable enhancements in bony union and strength despite previous surgical bed irradiation. METHODS: Two groups of murine left hemimandibles were exposed to a human equivalent radiation dosage fractionated over 5 daily doses of 7 Gy...
September 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28930496/american-telemedicine-association-practice-guidelines-for-telemental-health-with-children-and-adolescents
#5
Kathleen Myers, Eve-Lynn Nelson, Terry Rabinowitz, Donald Hilty, Deborah Baker, Sara Smucker Barnwell, Geoffrey Boyce, Lynn F Bufka, Sharon Cain, Lisa Chui, Jonathan S Comer, Carroll Cradock, Felissa Goldstein, Barb Johnston, Elizabeth Krupinski, Katherine Lo, David D Luxton, S David McSwain, Jennifer McWilliams, Steve North, Jay Ostrowsky, Antonio Pignatiello, David Roth, Jay Shore, Carolyn Turvey, James R Varrell, Shawna Wright, Jordana Bernard
No abstract text is available yet for this article.
September 20, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28929975/trait-and-facet-level-predictors-of-first-onset-depressive-and-anxiety-disorders-in-a-community-sample-of-adolescent-girls
#6
Brandon L Goldstein, Roman Kotov, Greg Perlman, David Watson, Daniel N Klein
BACKGROUND: Individual differences in neuroticism, extraversion, and conscientiousness are associated with, and may predict onset of, internalizing disorders. These general traits can be parsed into facets, but there is a surprising paucity of research on facet risk for internalizing disorders. We examined general traits and facets of neuroticism, extraversion, and conscientiousness in predicting first onsets of depressive and anxiety disorders. METHODS: A community sample of 550 adolescent females completed general and facet-level personality measures and diagnostic interviews...
September 20, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28924187/the-ipsych2012-case-cohort-sample-new-directions-for-unravelling-genetic-and-environmental-architectures-of-severe-mental-disorders
#7
C B Pedersen, J Bybjerg-Grauholm, M G Pedersen, J Grove, E Agerbo, M Bækvad-Hansen, J B Poulsen, C S Hansen, J J McGrath, T D Als, J I Goldstein, B M Neale, M J Daly, D M Hougaard, O Mors, M Nordentoft, A D Børglum, T Werge, P B Mortensen
The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder...
September 19, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28923856/genomic-activation-of-pparg-reveals-a-candidate-therapeutic-axis-in-bladder-cancer
#8
Jonathan T Goldstein, Ashton C Berger, Juliann Shih, Fujiko F Duke, Laura Furst, David J Kwiatkowski, Andrew D Cherniack, Matthew Meyerson, Craig A Strathdee
The PPARG gene encoding the nuclear receptor PPAR-gamma is activated in bladder cancer, either directly by gene amplification or mutation, or indirectly by mutation of the RXRA gene which encodes the heterodimeric partner of PPAR-gamma. Here we show that activating alterations of PPARG or RXRA lead to a specific gene expression signature in bladder cancers. Reducing PPARG activity, whether by pharmacologic inhibition or genetic ablation, inhibited proliferation of PPARG-activated bladder cancer cells. Our results offer a preclinical proof of concept for PPARG as a candidate therapeutic target in bladder cancer...
September 18, 2017: Cancer Research
https://www.readbyqxmd.com/read/28919165/validation-of-the-vectra-h1-portable-three-dimensional-photogrammetry-system-for-facial-imaging
#9
L Camison, M Bykowski, W W Lee, J C Carlson, J Roosenboom, J A Goldstein, J E Losee, S M Weinberg
Three-dimensional (3D) surface imaging using stereophotogrammetry has become increasingly popular in clinical settings, offering advantages for surgical planning and outcome evaluation. The handheld Vectra H1 is a low-cost, highly portable system that offers several advantages over larger stationary cameras, but independent technical validation is currently lacking. In this study, 3D facial images of 26 adult participants were captured with the Vectra H1 system and the previously validated 3dMDface system. Using error magnitude statistics, 136 linear distances were compared between cameras...
September 14, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28919001/pharmacological-inhibition-of-aldh1a-enzymes-suppresses-weight-gain-in-a-mouse-model-of-diet-induced-obesity
#10
Michael Haenisch, Piper M Treuting, Thea Brabb, Alex S Goldstein, Kathryn Berkseth, John K Amory, Jisun Paik
BACKGROUND: Retinoic acid (RA) is known to play a role in weight regulation. Because mice without ALDH1A1, a major RA synthesizing enzyme, are resistant to diet-induced obesity, we tested a hypothesis that pharmacological inhibition of RA synthesis can suppress weight gain in a murine model of diet-induced obesity. METHODS: C57BL/6J male mice were fed a high fat diet (HFD) for 8 weeks to induce obesity and then randomized to a HFD with or without WIN 18,446, an RA synthesis inhibitor, for an additional 9 weeks...
September 11, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28918243/homeostatic-systems-biocybernetics-and-autonomic-neuroscience
#11
REVIEW
David S Goldstein, Irwin J Kopin
In this review we describe a series of major concepts introduced during the past 150years that have contributed to our current understanding about how physiological processes required for well-being and survival are regulated. One can theorize that hierarchical networks involving input-output relationships continuously orchestrate and learn adaptive patterns of observable behaviors, cognition, memory, mood, and autonomic systems. Taken together, these networks function as "good regulators" determining levels of internal variables and act as if there were homeostatic comparators ("homeostats")...
September 5, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28917368/improving-vasomotor-symptoms-psychological-symptoms-and-health-related-quality-of-life-in-peri-or-post-menopausal-women-through-yoga-an-umbrella-systematic-review-and-meta-analysis
#12
REVIEW
M Shepherd-Banigan, K M Goldstein, R R Coeytaux, J R McDuffie, A P Goode, A S Kosinski, M G Van Noord, D Befus, S Adam, V Masilamani, A Nagi, J W Williams
OBJECTIVES: Vasomotor symptoms (VMS), commonly reported during menopausal transition, negatively affect psychological health and health-related quality of life (HRQoL). While hormone therapy is an effective treatment, its use is limited by concerns about possible harms. Thus, many women with VMS seek nonhormonal, nonpharmacologic treatment options. However, evidence to guide clinical recommendations is inconclusive. This study reviewed the effectiveness of yoga, tai chi and qigong on vasomotor, psychological symptoms, and HRQoL in peri- or post-menopausal women...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28916674/anticoagulation-in-patients-with-atrial-fibrillation-in-the-setting-of-prior-hemorrhage-an-ongoing-dilemma
#13
REVIEW
Larry B Goldstein
No abstract text is available yet for this article.
September 15, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28915351/relaxation-dynamics-vs-crystallization-kinetics-in-the-amorphous-state-the-case-of-stiripentol
#14
Guadalupe N Ruiz, Michela Romanini, Maria Del Barrio, Josep Ll Tamarit, Luis C Pardo, Roberto Macovez
With the aim of finding a correlation between the crystallization kinetics and the molecular dynamics of a substance that would allow to predict its crystallization time as a function of temperature for a given α relaxation time, we have studied Stiripentol, an anticonvulsant drug. Stiripentol has been characterized in its supercooled liquid, and amorphous (glass) and crystalline states by the concurrent use of Broadband Dielectric Spectroscopy (BDS), differential scanning calorimetry, x-ray diffraction and optical microscopy...
September 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28914269/looking-beyond-the-exome-a-phenotype-first-approach-to-molecular-diagnostic-resolution-in-rare-and-undiagnosed-diseases
#15
Loren D M Pena, Yong-Hui Jiang, Kelly Schoch, Rebecca C Spillmann, Nicole Walley, Nicholas Stong, Sarah Rapisardo Horn, Jennifer A Sullivan, Allyn McConkie-Rosell, Sujay Kansagra, Edward C Smith, Mays El-Dairi, Jane Bellet, Martha Ann Keels, Joan Jasien, Peter G Kranz, Richard Noel, Shashi K Nagaraj, Robert K Lark, Daniel S G Wechsler, Daniela Del Gaudio, Marco L Leung, Laura G Hendon, Collette C Parker, Kelly L Jones, David B Goldstein, Vandana Shashi
PurposeTo describe examples of missed pathogenic variants on whole-exome sequencing (WES) and the importance of deep phenotyping for further diagnostic testing.MethodsGuided by phenotypic information, three children with negative WES underwent targeted single-gene testing.ResultsIndividual 1 had a clinical diagnosis consistent with infantile systemic hyalinosis, although WES and a next-generation sequencing (NGS)-based ANTXR2 test were negative. Sanger sequencing of ANTXR2 revealed a homozygous single base pair insertion, previously missed by the WES variant caller software...
September 14, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28913920/dramatic-pretend-play-games-uniquely-improve-emotional-control-in-young-children
#16
Thalia R Goldstein, Matthew D Lerner
Pretense is a naturally occurring, apparently universal activity for typically developing children. Yet its function and effects remain unclear. One theorized possibility is that pretense activities, such as dramatic pretend play games, are a possible causal path to improve children's emotional development. Social and emotional skills, particularly emotional control, are critically important for social development, as well as academic performance and later life success. However, the study of such approaches has been criticized for potential bias and lack of rigor, precluding the ability to make strong causal claims...
September 15, 2017: Developmental Science
https://www.readbyqxmd.com/read/28913605/emergency-neurological-life-support-status-epilepticus
#17
Jan Claassen, Joshua N Goldstein
Patients with prolonged or rapidly recurring convulsions lasting more than 5 min should be considered to be in status epilepticus (SE) and receive immediate resuscitation. Although there are few randomized clinical trials, available evidence and experience suggest that early and aggressive treatment of SE improves patient outcomes, for which reason this was chosen as an Emergency Neurological Life Support protocol. The current approach to the emergency treatment of SE emphasizes rapid initiation of adequate doses of first line therapy, as well as accelerated second line anticonvulsant drugs and induced coma when these fail, coupled with admission to a unit capable of neurological critical care and electroencephalography monitoring...
September 14, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28911061/international-cancer-seminars-a-focus-on-esophageal-squamous-cell-carcinoma
#18
G Murphy, V McCormack, B Abedi-Ardekani, M Arnold, M C Camargo, N A Dar, S M Dawsey, A Etemadi, R C Fitzgerald, D E Fleischer, N D Freedman, A M Goldstein, S Gopal, M Hashemian, N Hu, P L Hyland, B Kaimila, F Kamangar, R Malekzadeh, C G Mathew, D Menya, G Mulima, M M Mwachiro, A Mwasamwaja, N Pritchett, Y-L Qiao, L F Ribeiro-Pinto, M Ricciardone, J Schüz, F Sitas, P R Taylor, K Van Loon, S-M Wang, W-Q Wei, C P Wild, C Wu, C C Abnet, S J Chanock, P Brennan
The International Agency for Research on Cancer (IARC) and the US National Cancer Institute (NCI) have initiated a series of cancer-focused seminars [Scelo G, Hofmann JN, Banks RE et al. International cancer seminars: a focus on kidney cancer. Ann Oncol 2016; 27(8): 1382-1385]. In this, the second seminar, IARC and NCI convened a workshop in order to examine the state of the current science on esophageal squamous cell carcinoma etiology, genetics, early detection, treatment, and palliation, was reviewed to identify the most critical open research questions...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28910639/rna-recombination-enhances-adaptability-and-is-required-for-virus-spread-and-virulence
#19
Yinghong Xiao, Igor M Rouzine, Simone Bianco, Ashley Acevedo, Elizabeth Faul Goldstein, Mikhail Farkov, Leonid Brodsky, Raul Andino
No abstract text is available yet for this article.
September 13, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28904720/lodox-reveals-the-ideal-body
#20
Lara Nicole Goldstein, Sameer Carim
No abstract text is available yet for this article.
2017: Pan African Medical Journal
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