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https://www.readbyqxmd.com/read/28329196/diabetic-patients-with-acute-coronary-syndromes-in-contemporary-european-registries-characteristics-and-outcomes
#1
Maddalena Lettino, Pontus Andell, Uwe Zeymer, Petr Widimsky, Nicolas Danchin, Alfredo Bardaji, Jose A Barrabes, Angel Cequier, Marc J Claeys, Leonardo De Luca, Jakob Dörler, David Erlinge, Paul Erne, Patrick Goldstein, Sasha M Koul, Gilles Lemesle, Thomas F Lüscher, Christian M Matter, Gilles Montalescot, Dragana Radovanovic, Jose Lopez Sendón, Petr Tousek, Franz Weidinger, Clive F M Weston, Azfar Zaman, Jin Li, J Wouter Jukema
Aims: Among patients with acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at particularly high risk of recurrent cardiovascular events and premature death. We aimed to provide a descriptive overview of unadjusted analyses of patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in contemporary registries in Europe. Methods and results: A total of 10 registries provided data in a systematic manner on ACS patients with DM (total n =28 899), and without DM (total n= 97 505)...
March 10, 2017: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28328788/early-presence-of-sleep-spindles-on-electroencephalography-is-associated-with-good-outcome-after-pediatric-cardiac-arrest
#2
Laurence Ducharme-Crevier, Craig A Press, Jonathan E Kurz, Michele G Mills, Joshua L Goldstein, Mark S Wainwright
OBJECTIVES: The role of sleep architecture as a biomarker for prognostication after resuscitation from cardiac arrest in children hospitalized in an ICU remains poorly defined. We sought to investigate the association between features of normal sleep architecture in children after cardiac arrest and a favorable neurologic outcome at 6 months. DESIGN: Retrospective review of medical records and continuous electroencephalography monitoring. SETTING: Cardiac and PICU of a tertiary children's hospital...
March 21, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28328615/patient-reported-experience-of-diagnosis-management-and-burden-of-neuroendocrine-tumors-results-from-a-large-patient-survey-in-the-united-states
#3
Edward M Wolin, John Leyden, Grace Goldstein, Teodora Kolarova, Ron Hollander, Richard R P Warner
OBJECTIVES: The aim of this survey was to examine the experience of patients with neuroendocrine tumors (NETs) to raise awareness of the NET-related burden and identify unmet needs. Here, we report data from patients in the United States. METHODS: Patients with NETs participated in a 25-minute anonymous survey, conducted primarily online from February to May 2014. Survey questions captured information on sociodemographics, clinical characteristics, NET diagnostic experience, disease impact/management, interaction with medical teams, and NETs knowledge/awareness...
March 21, 2017: Pancreas
https://www.readbyqxmd.com/read/28325978/toward-a-new-data-standard-for-combined-marine-biological-and-environmental-datasets-expanding-obis-beyond-species-occurrences
#4
Daphnis De Pooter, Ward Appeltans, Nicolas Bailly, Sky Bristol, Klaas Deneudt, Menashè Eliezer, Ei Fujioka, Alessandra Giorgetti, Philip Goldstein, Mirtha Lewis, Marina Lipizer, Kevin Mackay, Maria Marin, Gwenaëlle Moncoiffé, Stamatina Nikolopoulou, Pieter Provoost, Shannon Rauch, Andres Roubicek, Carlos Torres, Anton van de Putte, Leen Vandepitte, Bart Vanhoorne, Matteo Vinci, Nina Wambiji, David Watts, Eduardo Klein Salas, Francisco Hernandez
No abstract text is available yet for this article.
2017: Biodiversity Data Journal
https://www.readbyqxmd.com/read/28325112/potential-of-personal-health-record-portals-in-the-care-of-individuals-with-spinal-cord-injuries-and-disorders-provider-perspectives
#5
Jennifer N Hill, Bridget M Smith, Frances M Weaver, Kim M Nazi, Florian P Thomas, Barry Goldstein, Timothy P Hogan
CONTEXT/OBJECTIVE: Although personal health record (PHR) portals are designed for patients, healthcare providers are a key influence in how patients use their features and realize benefits from them. A few studies have examined provider attitudes toward PHR portals, but none have focused on those who care for individuals with spinal cord injuries and disorders (SCI/D). We characterize SCI/D provider perspectives of PHR portals, including perceived advantages and disadvantages of PHR portal use in SCI/D care...
March 21, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28323362/body-mass-index-and-prognosis-in-patients-with-head-and-neck-cancer
#6
Ricardo Ribeiro Gama, Yuyao Song, Qihuang Zhang, M Catherine Brown, Jennifer Wang, Steven Habbous, Li Tong, Shao Hui Huang, Brian O'Sullivan, John Waldron, Wei Xu, David Goldstein, Geoffrey Liu
BACKGROUND: Body mass index (BMI) has been associated variably with head and neck cancer outcomes. We evaluated the association between BMI at either diagnosis or at early adulthood head and neck cancer outcomes. METHODS: Patients with invasive head and neck squamous cell cancer at Princess Margaret Cancer Centre in Toronto, Canada, were surveyed on tobacco and alcohol exposure, performance status, comorbidities, and BMI at diagnosis. A subset also had data collected for BMI at early adulthood...
March 21, 2017: Head & Neck
https://www.readbyqxmd.com/read/28323004/fresh-or-cryopreserved-cd34-selected-mobilized-peripheral-blood-stem-and-progenitor-cells-for-the-treatment-of-poor-graft-function-following-allogeneic-hematopoietic-cell-transplantation
#7
Armin Ghobadi, Mark A Fiala, Giridharan Ramsingh, Feng Gao, Camille N Abboud, Keith Stockerl-Goldstein, Geoffrey L Uy, Brenda J Grossman, Peter Westervelt, John F DiPersio
CD34(+)-selected stem cell boost (SCB) without conditioning have recently been utilized for poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) with promising results. Unfortunately, many patients have been unable to receive the boost infusion as their donors were unwilling or unable to undergo an additional stem cell collection. Therefore, we conducted this study utilizing either fresh or cryopreserved peripheral blood stem cell products to create CD34(+)-selected boost infusions for the treatment of PGF...
March 17, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28322401/comparisons-of-mn2s2vs-bipyridine-as-redox-active-ligands-to-manganese-and-rhenium-in-l-l-m-co-3cl-complexes
#8
Allen M Lunsford, Kristina F Goldstein, Matthew A Cohan, Jason A Denny, Nattamai Bhuvanesh, Shengda Ding, Michael B Hall, Marcetta Y Darensbourg
The bipyridine ligand is renowned as a photo- and redox-active ligand in catalysis; the latter has been particularly explored in the complex Re(bipy)(CO)3Cl for CO2 reduction. We ask whether a bidentate, redox-active MN2S2 metallodithiolate ligand in heterobimetallic complexes of Mn and Re might similarly serve as a receptor and conduit of electrons. In order to assess the electrochemical features of such designed bimetallics, a series of complexes featuring redox active MN2S2 metallodithiolates, with M = Ni(2+), {Fe(NO)}(2+), and {Co(NO)}(2+), bound to M'(CO)3X, where M' = Mn and Re, were synthesized and characterized using IR and EPR spectroscopies, X-ray diffraction, cyclic voltammetry, and density functional theory (DFT) computations...
March 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28319597/relationship-between-changes-in-blood-pressure-and-left-ventricular-mass-over-1-year-in-end-stage-renal-disease
#9
Bradley Sarak, Ron Wald, Marc B Goldstein, Djeven P Deva, Jonathon Leipsic, Mercedeh Kiaii, General Leung, Joseph J Barfett, Jeffrey Perl, Darren A Yuen, Kim A Connelly, Andrew T Yan
OBJECTIVE: The optimal timing of blood pressure (BP) measurement is not firmly established for patients undergoing hemodialysis. We sought to assess which BP measurement change best correlates with changes in left ventricular mass index (LVMI) over 1 year in patients with end-stage renal disease. METHODS: Fifty-seven patients were included in a prospective cohort study comparing the cardiovascular impact of conversion to in-center nocturnal hemodialysis versus continuing conventional hemodialysis...
March 17, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28319561/pediatric-enteric-neuropathies-diagnosis-and-current-management
#10
Maggie L Westfal, Allan M Goldstein
PURPOSE OF REVIEW: Neurointestinal diseases are increasingly recognized as causes of significant gastrointestinal morbidity in children. This review highlights the most common pediatric enteric neuropathies and their diagnosis and management, emphasizing insights and discoveries from the most recent literature available. RECENT FINDINGS: The embryologic and histopathologic causes of enteric neuropathies are varied. They range from congenital aganglionosis in Hirschsprung disease, to autoimmune-mediated loss of neuronal subtypes in esophageal achalasia and Chagas disease, to degenerative neuropathies in some cases of chronic intestinal pseudo-obstruction and gastroparesis...
March 17, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28319273/gastric-microbiota-features-associated-with-cancer-risk-factors-and-clinical-outcomes-a-pilot-study-in-gastric-cardia-cancer-patients-from-shanxi-china
#11
Guoqin Yu, Nan Hu, Lemin Wang, Chaoyu Wang, Xiao-You Han, Mike Humphry, Jacques Ravel, Christian C Abnet, Philip R Taylor, Alisa M Goldstein
Little is known about the link between gastric microbiota and the epidemiology of gastric cancer. In order to determine the epidemiologic and clinical relevance of gastric microbiota, we used 16S ribosomal RNA gene sequencing analysis to characterize the composition and structure of the gastric microbial community of 80 paired samples (non-malignant and matched tumor tissues) from gastric cardia adenocarcinoma (GCA) patients in Shanxi, China. We also used PICRUSt to predict microbial functional profiles. Compared to patients without family history of upper gastrointestinal (UGI) cancer in the non-malignant gastric tissue microbiota, patients with family history of UGI cancer had higher Helicobacter pylori (Hp) relative abundance (median: 0...
March 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28318380/pup-mortality-and-evidence-for-pathogen-exposure-in-galapagos-sea-lions-zalophus-wollebaeki-on-san-cristobal-island-galapagos-ecuador
#12
Judith Denkinger, Nataly Guevara, Sofia Ayala, Juan Carlos Murillo, Maximilian Hirschfeld, Ignasi Montero-Serra, Katharina Fietz, Tracey Goldstein, Mark Ackermann, Veronica Barragán, Francisco Cabrera, Cristina Chavez, Edward J Dubovi, Jael Martinez, Gabriel Trueba
The Galapagos sea lion ( Zalophus wollebaeki ), an endangered species, experiences high pup mortality (up to 100%) in years when El Niño events reduce food supply in the Galapagos Islands. Mortality of pups in non-El Niño years is estimated to be 5% in undisturbed colonies. From 2009 to 2012 we observed high pup mortality (up to 66%) in colonies close to the Galapagos capital, Puerto Baquerizo Moreno, where contact with humans, domestic animals, and rats is frequent. Gross postmortem findings from 54 pups included hemorrhagic lesions in liver and congestion in lungs; histopathology suggested a possible association with infectious diseases...
March 20, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28317529/repigmentation-through-melanocyte-regeneration-in-vitiligo
#13
REVIEW
Stanca A Birlea, Nathaniel B Goldstein, David A Norris
Repigmentation in vitiligo is the process that replaces, in the epidermal basal layer of vitiligo skin, the mature melanocytes that have been killed by cytotoxic T cells specific for melanocyte antigens. It consists of mobilization of melanocyte precursors in the hair follicle bulge and infundibulum to proliferate, migrate, and differentiate into mature melanocytes, moving from the hair follicle bulge to the interfollicular epidermis. The most common clinical presentation of repigmentation in vitiligo is the perifollicular pattern...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28315578/longitudinal-sleep-phenotypes-among-offspring-of-bipolar-parents-and-community-controls
#14
Jessica C Levenson, Adriane Soehner, Brian Rooks, Tina R Goldstein, Rasim Diler, John Merranko, David Axelson, Ben I Goldstein, David A Brent, Danella Hafeman, Mary Beth Hickey, Kelly Monk, Dara Sakolsky, David J Kupfer, Boris Birmaher
BACKGROUND: Sleep disturbances are a prominent feature of bipolar disorder (BP). However, it remains unclear how sleep phenotypes may evolve among at-risk youth, and their relevance to BP onset. METHODS: Pittsburgh Bipolar Offspring Study (BIOS) offspring (ages 10-18) and their parents completed assessments approximately every two years pertaining to current psychopathology and offspring sleep habits. A latent transition analysis (LTA) identified latent sleep groups within offspring based on their ratings of six sleep domains using the School Sleep Habits Survey...
March 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28315024/autonomic-function-tests-introduction-to-the-series
#15
EDITORIAL
David S Goldstein, William P Cheshire
No abstract text is available yet for this article.
March 17, 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28314241/characterizing-articulation-in-apraxic-speech-using-real-time-magnetic-resonance-imaging
#16
Christina Hagedorn, Michael Proctor, Louis Goldstein, Stephen M Wilson, Bruce Miller, Maria Luisa Gorno-Tempini, Shrikanth S Narayanan
Purpose: Real-time magnetic resonance imaging (MRI) and accompanying analytical methods are shown to capture and quantify salient aspects of apraxic speech, substantiating and expanding upon evidence provided by clinical observation and acoustic and kinematic data. Analysis of apraxic speech errors within a dynamic systems framework is provided and the nature of pathomechanisms of apraxic speech discussed. Method: One adult male speaker with apraxia of speech was imaged using real-time MRI while producing spontaneous speech, repeated naming tasks, and self-paced repetition of word pairs designed to elicit speech errors...
March 17, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28306670/innovations-in-cardiac-transplantation
#17
Reema Hasan, Ashraf Abou El Ela, Daniel Goldstein
PURPOSE OF REVIEW: As the number of people living with heart failure continues to grow, future treatments will focus on efficient donor organ donation and ensuring safe and durable outcomes. This review will focus on organ procurement, graft surveillance and emerging therapies. RECENT FINDINGS: Preliminary studies into donation after cardiac death have indicated that this may be an effective means to increase the donor pool. Novel preservation techniques that include ex-vivo perfusion to improve donor metabolic stabilization prior to implantation may also expand the donor pool...
March 16, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28306513/tardigrades-use-intrinsically-disordered-proteins-to-survive-desiccation
#18
Thomas C Boothby, Hugo Tapia, Alexandra H Brozena, Samantha Piszkiewicz, Austin E Smith, Ilaria Giovannini, Lorena Rebecchi, Gary J Pielak, Doug Koshland, Bob Goldstein
Tardigrades are microscopic animals that survive a remarkable array of stresses, including desiccation. How tardigrades survive desiccation has remained a mystery for more than 250 years. Trehalose, a disaccharide essential for several organisms to survive drying, is detected at low levels or not at all in some tardigrade species, indicating that tardigrades possess potentially novel mechanisms for surviving desiccation. Here we show that tardigrade-specific intrinsically disordered proteins (TDPs) are essential for desiccation tolerance...
March 16, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28306149/medicare-access-and-chip-reauthorization-act-what-do-geriatrics-healthcare-professionals-need-to-know-about-the-quality-payment-program
#19
Kathleen T Unroe, Peter A Hollmann, Alanna C Goldstein, Michael L Malone
Commencing in 2017, the Medicare Access and CHIP Reauthorization Act (MACRA) of 2015 will change how Medicare pays health professionals. By enacting MACRA, Congress brought an end to the (un)sustainable growth rate formula while also setting forth a vision for how to transform the U.S. healthcare system so that clinicians deliver higher-quality care with smarter spending by the Centers for Medicare and Medicaid Services (CMS). In October 2016, CMS released the first of what stakeholders anticipate will be a number of (annual) rules related to implementation of MACRA...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28304122/comparative-study-of-magnetic-resonance-defaecography-and-evacuation-proctography-in-the-evaluation-of-obstructed-defaecation
#20
A Zafa, C Seretis, M Feretis, S Karandikar, S C Williams, M Goldstein, M Chapman
AIM: Obstructed defaecation syndrome (ODS) is a common condition of multifactorial aetiology and requires specialised evaluation. Accurate and reproducible pelvic floor imaging is imperative for multidisciplinary decision-making. Evacuation Proctography (EP) and Magnetic Resonance Defaecography (MRD) are the main imaging modalities used to assess dynamic pelvic floor function. The aim of this prospective study was to compare the findings and acceptability of MRD and EP in the same cohort of patients...
March 17, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
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