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https://www.readbyqxmd.com/read/28551945/targeting-ablation-strategies-and-electro-anatomical-systems-for-different-atrial-fibrillation-patterns
#1
Francesco Santoro, Christian H Heeger, Andreas Metzner, Natale D Brunetti, Matteo DI Biase, Karl-Heinz Kuck, Feifan Ouyang
INTRODUCTION: Catheter ablation (CA) is an established and widespread treatment option for drug refractory atrial fibrillation (AF). CA has undergone considerable improvements during the last years and several ablation strategies have been proposed for different AF patterns. EVIDENCE ACQUISITION: The main cornerstone is the electrical isolation of pulmonary veins (PVs) especially among patients with paroxysmal AF. This can be achieved mainly with the use of radiofrequency or cryo-energy...
May 25, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28551935/-comparison-of-quality-of-colonoscopy-in-an-academic-hospital-vs-a-community-hospital-outpatient-service
#2
Badira Makhoul, Muhammad Khatib, Dana Ben Hur, Jesse Lachter
BACKGROUND: Extensive use of colonoscopy in hospitals and community clinics has highlighted the need to assess the quality of the procedures in order to reduce costs and increase their efficiency. OBJECTIVES: This institutional review board (IRB)-approved study aimed to compare the quality of colonoscopies performed in a teaching hospital to those performed at a community health service. METHODS: Demographic information, time of procedure, indications, quality of bowel preparation, premedication, depth of examination, polyp detection, biopsies and followup recommendations were retrospectively obtained from 700 colonoscopy reports from the Rambam Healthcare Campus and 824 colonoscopy reports from Elisha...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551930/-laboratory-tests-and-radiological-imaging-diagnostic-tools-that-share-information-and-can-be-functionally-integrated
#3
Michael Mayer
In spite of apparent disparity between the specialties of radiological imaging, pathology and laboratory analysis, the medical diagnostic information that these sources provide have a lot in common and can be effectively utilized by sharing quantitative and qualitative results through modern information technology processes. Informaticsbased integration of radiological imaging, digital images of anatomical and molecular pathology and clinical laboratory results enables earlier, more sensitive and precise diagnosis, resulting in the more efficient treatment of patients...
March 2017: Harefuah
https://www.readbyqxmd.com/read/28551925/-clinical-characteristics-of-male-patients-with-osteoporosis-referred-to-the-endocrine-clinic-of-a-tertiary-hospital
#4
Gloria Tsvetov, Ilana Shraga-Slutzky, Dania Hirsch, Hiba Masri, Tzippy Shohat, Alexander Gorshtein, Ilan Shimon
INTRODUCTION: Osteoporosis in men is underdiagnosed and undertreated. The prevalence of male osteoporosis increases with age and it becomes a significant public health burden. Currently, there are a few clinical studies on male osteoporosis with limited knowledge of effective therapeutic options. AIMS: Our study aimed to characterize men with osteoporosis in a referral metabolic clinic in Rabin Medical Center at the Beilinson Campus. METHODS: In this study we retrospectively analyzed the medical records of 270 consecutive male patients with osteoporosis diagnosed and treated in our clinic during 2013...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551919/-utilization-of-whole-exome-sequencing-in-diagnostics-of-genetic-disease-rabin-medical-center-s-experience
#5
Lior Cohen, Naama Orenstein, Monica Weisz-Hubshman, Lily Bazak, Bella Davidov, Eyal Reinstein, Shay Tzur, Doron Behar, Pola Smirin-Yosef, Mali Salmon-Divon, Amit Gross, Mordechai Shohat, Lina Basel-Vanagaite
INTRODUCTION: Whole exome sequencing is a diagnostic approach for the identification of molecular etiology in patients with suspected monogenic diseases. In this article we report on our experience with whole-exome sequencing (WES) of DNA samples taken from patients referred for genetic evaluation due to suspected undiagnosed genetic conditions. METHODS: Exome enrichment was achieved by Nextera Rapid Capture Expanded Exome Kit. Whole-exome sequencing was performed on Illumina HiSeq 2500...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551915/-characteristics-of-large-pericardial-effusion-in-a-well-defined-geographical-region
#6
Moanis Serhan, Ruhi Abdallah, Shaul Atar
BACKGROUND: Pericardial effusion can occur as a result of primary pericardial disease or secondary to systemic disease. Analysis of the features of pericardial effusion in correlation with clinical and demographic findings can help clinicians to determine the correct diagnosis and to choose the appropriate treatment and reduce patient mortality and morbidity. METHODS: Retrospective analysis of the characteristics of pericardial effusion and the prevalence of the different etiologies and their correlation with demographics, clinical characteristics and medical history in 86 patients admitted to Galilee Medical Center from 2001 to 2010 who underwent pericardiocentesis or pericardial window...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551910/-level-and-oxidation-of-beta-2-microglobulin-in-hemodialysis-patients-treated-with-intravenous-iron-during-dialysis-with-high-flux-compared-to-low-flux-dialyzers
#7
Regina Michelis, Shifra Sela, Alexander Lanzmann, Olga Tanchilevski, Revital Shurtz-Swirski, Batya Kristal
INTRODUCTION: Serum levels of β2-microglobulin (b2M) are significantly higher in patients with end stage renal failure undergoing hemodialysis (HD) and its accumulation accelerates Dialysis Related Amyloidosis (DRA). In HD patients low-flux dialysis, intravenous (IV) iron (administered for the treatment of anemia) affects ß2M removal during dialysis. IV iron also affects the oxidation of plasma proteins, including b2M. AIMS: To examine the effect of intravenous iron therapy on ß2M levels and oxidation in HD patients treated with high-flux compared with low-flux dialyzers...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551909/-dermatological-diseases-in-elderly-hospitalized-patients-in-the-galilee-medical-center-comparison-between-two-age-groups
#8
Maayan Lahav Sher, Orly Yakir, Ora Bitterman-Deutsch
INTRODUCTION: Although dermatologic conditions bring relatively few people to the Emergency Department, hospitalized patients, especially older people, often suffer from skin problems that contribute to their morbidity. AIMS: We wanted to identify the frequency, clinical course, treatment and influence on hospitalization of dermatologic conditions in patients hospitalized in internal and geriatric departments in Galilee Medical Center. We concentrated on two groups of adults, aged 40-65 years (adult group) and above 65 years (elderly group), in order to understand differences in the cause of referral, type of diagnosis and mode of treatment...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551907/-the-clinical-approach-to-diagnosis-and-treatment-of-hypothyroidism
#9
REVIEW
Amir Bashkin, Marina Nodelman
Hypothyroidism is the most frequent endocrinologic disorder after diabetes. It is caused by the insufficient production of thyroid hormones Thyroxine (T4) and Triiodothyronine (T3). T4 is the main hormone that is accumulated in the thyroid gland, while T3 is the active hormone that is produced from T4 in the peripheral tissues. More than 99% of the patients have primary hypothyroidism which is due to thyroid disorder mainly Hashimoto's thyroiditis or iatrogenic. Hypothyroidism is divided into sub-clinical when T4 is in the normal range and overt when it is low and usually the TSH level is higher than 10 mIU\L...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551905/-molecular-markers-for-prostate-cancer
#10
REVIEW
Dov Engelstein
Prostate cancer (PCa) is the most frequent malignancy and the second cause of death from malignancy in men in the Western world. Prostatic Specific Antigen (PSA) has been widely used as a possible marker for PCa for the last three decades, but its significant limitations are known, especially its lack of an exact cutoff level for diagnosis of PCa. Imprudent use of PSA has led to over-diagnosis and over-treatment in men with low risk PCa, not significant for survival. Therefore, researchers are looking for better and more accurate markers for diagnosis, treatment decisions and follow-up...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551897/-phacoemulsification-in-eyes-with-neovascular-age-related-macular-degeneration-amd
#11
Daniel Rappoport, Mordechai Goldberg, Amir Bukelman, Haya Katz, Lital Goldberg, Ayala Pollack
INTRODUCTION: Age-related macular degeneration (AMD) is the leading cause of blindness in the western world. The debate continues over the safety of cataract surgery in the setting of neovascular (wet) AMD. This retrospective review aims to describe our experience in treating patients with wet AMD, who underwent cataract surgery by phacoemulsification. METHODS: We prepared a retrospective chart review of patients treated in our clinic between the years 2006 - 2013...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551894/-advanced-abdominal-pregnancy
#12
REVIEW
David Rabinerson, Alexandra Berezowsky, Rinnat Gabbay-Benziv
Abdominal pregnancy is a very rare obstetric complication which is seriously hazardous to the mother as well as the fetus. It poses a diagnostic challenge to this day. Both maternal and fetal mortality rates in such cases are high, as well as the malformation rate among the affected fetus. The best diagnostic tools are ultrasound and MRI. The availability of these instruments, and especially the latter, is scarce in developing countries, hence the higher rate of this type of pregnancy in these regions. The higher incidence of abdominal pregnancy in developing countries is also associated with the greater prevalence of low socioeconomic status, pelvic infections and infertility - all are more prevalent in these countries...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551892/-integrative-medicine-and-chronic-lymphocytic-leukemia
#13
Tamar Tadmor
Chronic lymphatic leukemia is the most common leukemia in the western world. In recent years, new drugs and more effective therapy have been developed, allowing for better outcomes for symptomatic patients. In contrast, patients without evidence of active disease do not require therapy, but there is a need to identify a means of intervention that could prevent progression of their disease, with minimum exposure to any side effects. Herbs, supplements or vitamins have been tested as possible therapeutic intervention for these patients and the available results are summarized in this article...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551885/public-engagement-on-urban-air-pollution-an-exploratory-study-of-two-interventions
#14
Christian Oltra, Roser Sala, Àlex Boso, Sergi López Asensio
The use of portable sensors to measure air quality is a promising approach for the management of urban air quality given its potential to improve public participation in environmental issues and to promote healthy behaviors. However, not all the projects that use air quality mobile sensors consider the potential effects of their use on the attitudes and behaviors of non-expert individuals. This study explores the experiences, perceptions, attitudes, and behavioral intentions of 12 participants who used a real-time NO2 sensor over a period of 7 days in the metropolitan area of Barcelona and compares them with 16 participants who did not have access to the device but rather to documentary information...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28551882/medical-geology-of-endemic-goiter-in-kalutara-sri-lanka-distribution-and-possible-causes
#15
G W A R Fernando, P L C L Liyanage, Anushka Upamali Rajapaksha, Meththika Vithanage
This study assesses the distribution of goiter in the Kalutara District, Sri Lanka in order to find causative factors for the occurrence of goiter even after the salt iodization. A questionnaire survey was conducted at the household level and at the same time iodine and selenium levels of the water sources were analyzed. Questionnaire survey results indicated the highest numbers of goiter patients in the northern part where the lowest were found in the southern sector which may be due to the presence of acid sulfate soils...
May 27, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28551878/underreporting-of-congenital-rubella-in-italy-2010-2014
#16
Cristina Giambi, Antonino Bella, Antonietta Filia, Martina Del Manso, Gloria Nacca, Silvia Declich, Maria Cristina Rota
In accordance with the goals of the World Health Organization Regional Committee for Europe, the Italian national Measles and Rubella Elimination Plan 2010-2015 aimed to reduce the incidence of congenital rubella cases to <1 case/100,000 live births by 2015. In Italy, a passive national surveillance system for congenital rubella and rubella in pregnancy is active since 2005. We estimated the degree of underreporting of congenital rubella, performing a capture-recapture analysis of cases detected through two independent sources: the national surveillance system and the national hospital discharge database, in the years 2010-2014...
May 28, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28551874/coptidis-rhizoma-extract-inhibits-replication-of-respiratory-syncytial-virus-in-vitro-and-in-vivo-by-inducing-antiviral-state
#17
Byeong-Hoon Lee, Kiramage Chathuranga, Md Bashir Uddin, Prasanna Weeratunga, Myun Soo Kim, Won-Kyung Cho, Hong Ik Kim, Jin Yeul Ma, Jong-Soo Lee
Coptidis Rhizoma is derived from the dried rhizome of Ranunculaceous plants and is a commonly used traditional Chinese medicine. Although Coptidis Rhizoma is commonly used for its many therapeutic effects, antiviral activity against respiratory syncytial virus (RSV) has not been reported in detail. In this study, we evaluated the antiviral activities of Coptidis Rhizoma extract (CRE) against RSV in human respiratory tract cell line (HEp2) and BALB/c mice. An effective dose of CRE significantly reduces the replication of RSV in HEp2 cells and reduces the RSV-induced cell death...
June 2017: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/28551869/impact-of-chronic-stress-on-the-spatial-learning-and-gr-pkac-nf-%C3%AE%C2%BAb-signaling-in-the-hippocampus-and-cortex-in-rats-following-cholinergic-depletion
#18
Sun-Young Lee, Woo-Hyun Cho, Yo-Seob Lee, Jung-Soo Han
Studies have shown that the removal of the cholinergic innervation to the hippocampus induces dysfunction of the hypothalamic-pituitary-adrenocortical axis and decreases the number of glucocorticoid receptors (GRs). Subsequent studies have revealed that the loss of cholinergic input to the hippocampus reduces the expression of GRs and activates nuclear factor-kappa B (NF-κB) signaling through interactions with the cytoplasmic catalytic subunit of protein kinase A (PKAc). We examined the effects of chronic stress on cognitive status and GR-PKAc-NF-κB signaling in rats with a loss of cholinergic input to the hippocampus and cortex...
May 27, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28551865/pearls-and-pitfalls-of-hepatobiliary-and-splenic-trauma-what-every-trauma-radiologist-needs-to-know
#19
REVIEW
Joseph A Graves, Tarek N Hanna, Keith D Herr
With the universal acceptance of contrast-enhanced computed tomography (CT) as the imaging modality of first resort in the assessment of blunt abdominal injury, the trauma radiologist must be able to accurately and rapidly identify the range of CT manifestations of the traumatized abdomen. In this article, we lay out the fundamental principles in CT interpretation of blunt trauma to the hepatobiliary system and spleen, including vascular injury, with a focus on technical and interpretive pearls and pitfalls...
May 27, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28551863/core-curriculum-illustration-supination-external-rotation-trimalleolar-fracture
#20
Jake W Sharp, Rachael M Edwards
This is the 37th installment of a series that will highlight one case per publication issue from the bank of cases available online as part of the American Society of Emergency Radiology (ASER) educational resources. Our goal is to generate more interest in and on the use of our online materials. To view more cases online, please visit the ASER Core Curriculum and Recommendations for Study online at http://www.erad.org/page/CCIP_TOC .
May 27, 2017: Emergency Radiology
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