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https://www.readbyqxmd.com/read/27920178/animal-models-of-chikungunya-virus-infection-and-disease
#1
Nicole N Haese, Rebecca M Broeckel, David W Hawman, Mark T Heise, Thomas E Morrison, Daniel N Streblow
Chikungunya virus (CHIKV) is a reemerging alphavirus that causes acute febrile illness and severe joint pain in humans. Although acute symptoms often resolve within a few days, chronic joint and muscle pain can be long lasting. In the last decade, CHIKV has caused widespread outbreaks of unprecedented scale in the Americas, Asia, and the Indian Ocean island regions. Despite these outbreaks and the continued expansion of CHIKV into new areas, mechanisms of chikungunya pathogenesis and disease are not well understood...
December 15, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27916937/the-emergence-and-epidemiology-of-haff-disease-in-china
#2
REVIEW
Thomas Y K Chan
Haff disease is a rare syndrome of unexplained myalgia and rhabdomyolysis occurring within 24 h of consumption of certain types of cooked freshwater fish or crustacean. It is caused by a yet unidentified heat-stable toxin. In the present review of published case studies and official press releases, the main objective is to report the emergence and epidemiology of Haff disease in China. Haff disease first occurred in Beijing in 2000 and in Lianzhou and Liannan, Guangdong Province in 2009. Subsequent outbreaks mostly occurred in the Jiangsu Province-Nanjing, Yangzhou, Huai'an, and Yancheng...
December 1, 2016: Toxins
https://www.readbyqxmd.com/read/27916555/adx71943-and-adx71441-novel-positive-allosteric-modulators-of-the-gabab-receptor-with-distinct-central-peripheral-profiles-show-efficacy-in-the-monosodium-iodoacetate-model-of-chronic-osteoarthritis-pain-in-the-rat
#3
Mikhail Kalinichev, Tansy Donovan-Rodriguez, Françoise Girard, Hasnaá Haddouk, Isabelle Royer-Urios, Manfred Schneider, Simon T Bate, Cheryl Marker, James D Pomonis, Sonia Poli
We tested novel positive allosteric modulators (PAMs) of the γ-aminobutyric acid receptor B (GABAB), ADX71943 and ADX71441in the monosodium iodoacetate model of chronic osteoarthritis pain in rats with the objective to delineate the role of peripheral versus central GABAB receptor populations in modulation of chronic pain. Anesthetized Sprague-Dawley rats received an injection of monosodium iodoacetate into the knee and were tested for hyperalgesia starting post-MIA day 14. Effects of compounds on ipsilateral joint compression threshold were evaluated on post-MIA day 14 (after acute treatment), as well as after repeated, daily treatment on days 21 and 28 (ADX71943 only) and were compared to those of celecoxib (30mg/kg, p...
December 1, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27910093/headache-attributed-to-craniocervical-dystonia-a-little-known-headache
#4
Marcos Eugenio Ramalho Bezerra, Pedro Augusto Sampaio Rocha-Filho
BACKGROUND: Craniocervical dystonia is a focal or segmental dystonia in its distribution, classically known as spasmodic torticollis when in its pure cervical presentation. Although craniocervical dystonia has been recognized as a possible cause of headache since the publication of the second version of International Classification of Headache Disorders, there are few studies about this entity. METHOD: This was a narrative review. RESULTS: Craniocervical dystonia was associated with muscle pain in 67-89% of the cases...
December 2, 2016: Headache
https://www.readbyqxmd.com/read/27909636/imatinib-induced-ototoxicity-in-a-patient-with-gastrointestinal-stromal-tumor-gist
#5
Komal Wasif, Nawal Wasif, Muhammad W Saif
Imatinib (Gleevec) is a biological agent that is approved for the treatment of chronic myeloid leukemia (CML) as well as gastrointestinal stromal tumor (GIST). The most frequently seen adverse effects in patients treated with imatinib include superficial edema, muscle cramps, musculoskeletal pain, rash, fatigue, headache, abdominal pain, and joint pain. Ototoxicity has rarely been reported except in two cases. We report a case of bilateral irreversible sensorineural hearing loss (SNHL) caused by imatinib in a patient receiving this agent in the adjuvant setting...
October 26, 2016: Curēus
https://www.readbyqxmd.com/read/27906945/ganglion-cyst-at-the-proximal-tibiofibular-joint-in-a-patient-with-painless-foot-drop
#6
Abdulmuhsen Alsahhaf, Waleed Renno
Entrapment neuropathies of the fibular nerve and its branches are often underdiagnosed due to the lack of reliable diagnosis using clinical examination and electrophysiologic evaluation. Most fibular nerve compressions may be classified into 2 broad categories: (a) mechanical causes, which occur at fibrous or fibro-osseous tunnels, and (b) dynamic causes related to nerve injury during specific limb positioning. Foot drop resulting from weakness of the dorsiflexor muscles of the foot is a relatively uncommon presentation and closely related to L5 neuropathy caused by a disc herniation...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27904957/neck-pain-and-acute-dysphagia
#7
João Simões, José Romão, Anita Cunha, Sofia Paiva, António Miguéis
The acute tendinitis of the longus colli muscle is an unusual diagnosis in the cases of acute dysphagia with cervical pain. Is a self-limiting condition caused by abnormal calcium hydroxyapatite deposition in the prevertebral space and can cause pharyngeal swelling with impaired swallow. It is absolutely critical to make the differential diagnosis with deep cervical infections in order to avoid invasive treatments.
November 30, 2016: Dysphagia
https://www.readbyqxmd.com/read/27899787/mcardle-disease-misdiagnosed-as-meningitis
#8
Renata Siciliani Scalco, Sherryl Chatfield, Muhammad Hyder Junejo, Suzanne Booth, Jatin Pattni, Richard Godfrey, Ros Quinlivan
BACKGROUND McArdle disease is a glycogen storage disorder mainly characterized by exercise intolerance. Prolonged muscle contracture is also a feature of this condition and may lead to rhabdomyolysis (RM), which is a serious event characterized by acute skeletal muscle damage.  CASE REPORT A 44-year-old female patient presented with an acute contracture of the posterior neck muscles, causing severe nuchal rigidity. The contracture was induced during a dental extraction as she held her mouth open for a prolonged period, with her neck in a rigid position...
November 30, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27888843/normal-variants-accessory-muscles-about-the-ankle
#9
REVIEW
Yvonne Cheung
Accessory muscles around the ankle are commonly encountered as incidental findings on cross-sectional imaging. Mostly asymptomatic, accessory muscles sometimes mimic mass lesions. They have been implicated as the cause of tarsal tunnel syndrome, impingement of surrounding structures, and chronic pain. Distinguishing these muscles can be challenging, because some travel along a similar path. This article describes these accessory muscles in detail, including their relationships to the aponeurosis of the lower leg...
February 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/27886357/anterior-iliopsoas-impingement-due-to-a-malpositioned-acetabular-component-effective-relief-by-surgical-cup-reorientation
#10
Benjamin Schoof, Oliver Jakobs, Stefan Schmidl, Christian Lausmann, Florian Fensky, Johannes Beckmann, Thorsten Gehrke, Matthias Gebauer
BACKGROUND: Determining the aetiology of persistent pain following total hip arthroplasty (THA) can be challenging. Impingement of the iliopsoas muscle due to a malpositioned acetabular component after THA might be a potential cause of postoperative groin pain. METHODS: We retrospectively analysed the data of 12 consecutive patients from our orthopaedic department who underwent cup revision for painful iliopsoas impingement after primary THA. RESULTS: Thorough physical examination as well as radiological assessment of the included patients revealed that malpositioning of the acetabular component provoked iliopsoas impingement...
November 22, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/27883987/changes-in-lumbopelvic-rhythm-during-trunk-extension-in-adolescent-soccer-players
#11
Michio Tojima, Suguru Torii
Many adolescent athletes experience low back pain (LBP). Its causative factors include lower limb muscle tightness and hip-spine incoordination. Hip-spine coordination [or lumbopelvic rhythm, LPR] can be used to assess lower-limb and spine functions. We assessed the presence/absence of LBP in adolescent soccer players before and after a six-month period and divided them into four groups: no LBP both before and after the period (NBP group); LBP before but not after (PN group); LBP after but not before (NP group); and LBP both before and after (LBP group)...
November 15, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27882276/isolated-non-traumatic-bilateral-coronoid-process-fracture-of-the-mandible
#12
Nabil Al-Khalisi, Krishna Kumar, Natasha Acosta
Isolated bilateral fractures of the coronoid processes of the mandible occurred in this patient without any significant trauma. The definite etiology of this case is unknown, but possible causes or contributing factors may include acute reflex contraction of the patient's temporalis muscles leading to bilateral stress fractures, coronoid process hyperplasia, or the patient's long-term use of omeprazole. The planned treatment for this patient included pain control with Mobic and tramadol and splint fabrication followed by arch bar placement with training elastics for six weeks...
October 13, 2016: Curēus
https://www.readbyqxmd.com/read/27882240/t2-based-temperature-monitoring-in-bone-marrow-for-mr-guided-focused-ultrasound
#13
Eugene Ozhinsky, Misung Han, Matthew Bucknor, Roland Krug, Viola Rieke
BACKGROUND: Current clinical protocols for MR-guided focused ultrasound (MRgFUS) treatment of osseous lesions, including painful bone metastases and osteoid osteomas, rely on measurement of the temperature change in adjacent muscle to estimate the temperature of the bone. The goal of this study was to determine if T2-based thermometry could be used to monitor the temperature change in bone marrow during focused ultrasound ablation of bone lesions. METHODS: We investigated the dependence of T2 on temperature in ex vivo bovine yellow bone marrow at 3T and studied the influence of acquisition parameters on the T2 measurements...
2016: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/27875777/does-pelvic-floor-muscle-contraction-early-after-delivery-cause-perineal-pain-in-postpartum-women
#14
Hedwig Neels, Stefan De Wachter, Jean-Jacques Wyndaele, Michel Wyndaele, Alexandra Vermandel
OBJECTIVE: Pelvic floor muscle training is effective and necessary in the prevention and treatment of pelvic floor dysfunction during pregnancy and after childbirth. But because of the high prevalence of perineal pain observed in women after childbirth, many women and caregivers fear to start pelvic floor muscle training immediately after childbirth. However, it is unknown whether pelvic floor muscle contractions (PFMC) provoke perineal pain in women shortly after childbirth. Therefore, the main objective is to study whether PFMC performed immediately after childbirth is painful or not...
November 11, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27875493/acute-lumbar-paraspinal-myonecrosis-in-football-players-with-sickle-cell-trait-a-case-series
#15
E Randy Eichner, Brock Schnebel, Scott Anderson, James R Clugston, Heath Hale, Charlie Michaudet, John M Small
We report 6 cases of a novel syndrome of acute, exertional low back pain (LBP) in football players, 5 in college and one in the National Football League (NFL). All 6 are African-Americans with sickle cell trait (SCT). The acute LBP is severe and can be disabling, and the condition can be confused with muscle strain, discogenic pain, stress fracture, or other problems in athletes. Our evidence shows that this syndrome is caused by lumbar paraspinal myonecrosis (LPSMN), which likely often contributes to the lumbar paraspinal compartment syndrome...
November 21, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27866992/comorbidities-that-cause-pain-and-the-contributors-to-pain-in-individuals-with-chronic-obstructive-pulmonary-disease
#16
Yi-Wen Chen, Pat G Camp, Harvey O Coxson, Jeremy D Road, Jordan A Guenette, Michael A Hunt, W Darlene Reid
OBJECTIVE: To determine comorbidities that cause pain and the potential contributors to pain in individuals with COPD. DESIGN: Prospective cross-sectional survey study. SETTING: Pulmonary rehabilitation programs of six centers. PARTICIPANTS: A convenience sample of individuals with COPD who attended pulmonary rehabilitation programs (n=137). In total, 100 (73%) returned the survey packages. Of those responders, 96 (70%) participants were included in the analyses...
November 17, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27862644/bilateral-experimental-neck-pain-reorganize-axioscapular-muscle-coordination-and-pain-sensitivity
#17
S W Christensen, R P Hirata, T Graven-Nielsen
BACKGROUND: Neck pain is a large clinical problem where reorganized trunk and axioscapular muscle activities have been hypothesised contributing to pain persistence and pain hypersensitivity. This study investigated the effects of bilateral experimental neck pain on trunk and axioscapular muscle function and pain sensitivity. METHODS: In 25 healthy volunteers, bilateral experimental neck pain was induced in the splenius capitis muscles by hypertonic saline injections...
November 11, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27862037/early-onset-limb-girdle-muscular-dystrophy-2l-in-a-female-athlete
#18
Patrick R Blackburn, Duygu Selcen, Jessica L Jackson, Kimberly J Guthrie, Margot A Cousin, Nicole J Boczek, Kristin E Clift, Eric W Klee, Elliot L Dimberg, Paldeep S Atwal
INTRODUCTION: Limb-girdle muscular dystrophy-2L (LGMD2L) is an autosomal recessive muscular dystrophy caused by pathogenic variants in anoctamin-5 (ANO5). The disorder is characterized by weakness of the hip and shoulder girdles and of the lower limbs, with muscle atrophy. METHODS: We describe a woman with progressive weakness beginning at age 22 years in conjunction with back pain and myoglobinuria during physical exertion. Her serum CK levels ranged from 1,200-8,000 IU/L between the ages 22 and 34 years, and she was seen for a constant steady decline in muscle strength, which led to consultation for genetic testing...
November 11, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27853523/recent-advances-in-understanding-provoked-vestibulodynia
#19
REVIEW
Ahinoam Lev-Sagie, Steven S Witkin
Vulvodynia refers to pain in the vulva of at least 3 months' duration in the absence of a recognized underlying cause. Provoked, localized vestibulodynia is the term used to describe superficial pain confined to the vulvar vestibule, provoked by touch. This review will focus on provoked vestibulodynia with regard to its suggested causative factors and will discuss the role of inflammation, vulvovaginal infections, mucosal nerve fiber proliferation, hormonal associations, central pain mechanisms, pelvic floor muscle dysfunction, and genetic factors...
2016: F1000Research
https://www.readbyqxmd.com/read/27847707/relationship-between-hba1c-and-complex-regional-pain-syndrome-in-stroke-patients-with-type-2-diabetes-mellitus
#20
Jong Ho Choi, Ki Pi Yu, Yong-Soon Yoon, Eun Sil Kim, Ji Hyun Jeon
OBJECTIVE: To investigate the relationship between glycosylated hemoglobin A (HbA1c) and complex regional pain syndrome (CRPS) in stroke patients with type 2 diabetes mellitus (T2DM). METHODS: A retrospective chart review was performed of stroke patients from January 2012 to December 2013. We reviewed 331 patients and included 200 in the analysis. We divided them into CRPS and non-CRPS groups and compared them by age, gender, stroke lesion, cause of stroke, duration of T2DM, HbA1c (%), National Institutes of Health Stroke Scale score, affected shoulder flexor muscle strength, Fugl-Meyer Assessment score, motricity index, Functional Independence Measure, Korean version of Modified Barthel Index, blood glucose level on admission day, duration from stroke onset to HbA1c check, and duration from stroke onset to three-phase bone scan for CRPS diagnosis...
October 2016: Annals of Rehabilitation Medicine
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