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Chronic kidney disease, cancer

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https://www.readbyqxmd.com/read/28428650/routine-mammography-an-opportunity-for-the-diagnosis-of-chronic-degenerative-diseases-a-cross-sectional-study
#1
Flávio Augusto Teixeira Ronzani, Filomena Maria Kirchmaier, Nathália Mussi Monteze, Edson José de Carvalho Magacho, Marcus Gomes Bastos, Natália Maria da Silva Fernandes
OBJECTIVE: The aim of this study was to evaluate breast arterial calcification (BAC) detected on routine mammography, analyzing its association with chronic degenerative disease. MATERIALS AND METHODS: This was a cross-sectional study involving women treated at a specialized outpatient clinic for high-risk hypertension, diabetes, or chronic kidney disease, as well as volunteers who participated in a study to validate a method of screening for occult renal disease...
March 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28423118/obesity-and-kidney-disease-hidden-consequences-of-the-epidemic
#2
EDITORIAL
C P Kovesdy, S L Furth, C Zoccali
Obesity has become a worldwide epidemic and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term...
April 13, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28423031/comorbidities-of-rheumatoid-arthritis-results-from-the-korean-national-health-and-nutrition-examination-survey
#3
Hyemin Jeong, Sun Young Baek, Seon Woo Kim, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh, Hoon-Suk Cha
This study aimed to evaluate the prevalence of comorbidities in patients with rheumatoid arthritis (RA) compared with the non-RA population. The 2010-2012 Korea National Health and Nutrition Examination Survey (KNHANES), which assesses the general health status of populations in South Korea using interviews and basic health assessment, was analyzed retrospectively. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed in patients with RA compared with the non-RA population. The overall weighted (n = 37,453,158) prevalence of RA was 1...
2017: PloS One
https://www.readbyqxmd.com/read/28418894/urinary-rkip-p-rkip-is-a-potential-diagnostic-and-prognostic-marker-of-clear-cell-renal-cell-carcinoma
#4
Massimo Papale, Grazia Vocino, Giuseppe Lucarelli, Monica Rutigliano, Margherita Gigante, Maria Teresa Rocchetti, Francesco Pesce, Francesca Sanguedolce, Pantaleo Bufo, Michele Battaglia, Giovanni Stallone, Giuseppe Grandaliano, Giuseppe Carrieri, Loreto Gesualdo, Elena Ranieri
Clear cell Renal Cell Carcinoma (ccRCC) causes over 13,000 deaths each year, and about 20,000 new cases/year in Europe. In most cases, the causes are unknown and, most importantly, there are no reliable biomarkers for the diagnosis and prognosis of this disease. The search for sensitive biomarkers for early diagnosis and prognosis of clear cell Renal Cell Carcinoma (ccRCC) is currently a fast growing field. We carried out proteomics analysis of 93 urinary samples of healthy subjects (HS) and patients affected by ccRCC, prostate cancer (PCa) and chronic kidney disease (CKD), that was able to successfully distinguish each group...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415778/is-preoperative-chronic-kidney-disease-status-associated-with-oncologic-outcomes-in-upper-urinary-tract-urothelial-carcinoma-a-multicenter-propensity-score-matched-analysis
#5
Ho Song Yu, Jun Eul Hwang, Ho Seok Chung, Yang Hyun Cho, Myung Soo Kim, Eu Chang Hwang, Kyung Jin Oh, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu, Sung-Hoon Jung, Young Hoe Hur, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul-Sung Kim, Sung Gu Kang, Seok Ho Kang, Jun Cheon
PURPOSE: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). RESULTS: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancer-specific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28409437/prognostic-significance-of-pd-l1-expression-on-tumor-cells-and-tumor-infiltrating-mononuclear-cells-in-upper-tract-urothelial-carcinoma
#6
Bo Zhang, Wei Yu, Xueru Feng, Zheng Zhao, Yu Fan, Yisen Meng, Shuai Hu, Yun Cui, Qun He, Hong Zhang, Dong Li, Zhisong He, Liqun Zhou, Jie Jin, Wenke Han
Immunotherapy targeting the programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) pathway has shown promising results in several malignancies. However, the prognostic significance of PD-L1 expression remains unknown in patients with upper tract urothelial carcinoma (UTUC). This study aimed to evaluate PD-L1 expression and its association with clinicopathological characteristics and oncological outcomes in UTUC patients. PD-L1 expression on tumor cells and tumor-infiltrating mononuclear cells (TIMCs), and E-cadherin and N-cadherin expression on tumor cells were assessed by immunohistochemistry in a cohort of 162 patients with UTUC...
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28405130/mechanism-underlying-linezolid-induced-thrombocytopenia-in-a-chronic-kidney-failure-mouse-model
#7
Nao Nishijo, Yasuhiro Tsuji, Kazuhisa Matsunaga, Masahiko Kutsukake, Fumiyasu Okazaki, Shiro Fukumori, Hidefumi Kasai, Yoichi Hiraki, Ippei Sakamaki, Yoshihiro Yamamoto, Yoshiharu Karube, Hideto To
OBJECTIVE: To investigate the relationship between renal function and linezolid (LZD)-induced thrombocytopenia and elucidate the underlying mechanism using a chronic renal disease (CRD) mouse model. MATERIALS AND METHODS: CRD was induced in 5-week-old male Institute of Cancer Research (ICR) mice by 5/6 nephrectomy. After this procedure, LZD (25 and 100 mg/kg) was administered intraperitoneally once every day for 28 days. Platelet counts, white blood cell (WBC) counts, and hematocrit (HCT) levels were measured every 7 days...
January 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28396181/severity-of-preoperative-proteinuria-is-a-risk-factor-for-overall-mortality-in-patients-undergoing-nephrectomy
#8
David Y Yang, R Houston Thompson, Harras B Zaid, Christine M Lohse, Andrew D Rule, Stephen A Boorjian, Bradley C Leibovich, John C Cheville, Matthew K Tollefson
PURPOSE: Chronic kidney disease may adversely affect survival following nephrectomy. Proteinuria is increasingly used as a marker for kidney disease. However, the relationship between preoperative proteinuria and survival following nephrectomy remains incompletely characterized. We sought to evaluate the association of preoperative proteinuria with overall and cancer-specific survival using our institutional nephrectomy registry. MATERIALS AND METHODS: We identified 1,846 patients with localized clear cell renal cell carcinoma treated with curative intent (radical or partial nephrectomy) between 1995 and 2010...
April 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28387829/hereditary-polycystic-kidney-disease-is-characterized-by-lymphopenia-across-all-stages-of-kidney-dysfunction-an-observational-study
#9
Steven Van Laecke, Tessa Kerre, Evi V Nagler, Bart Maes, Rogier Caluwe, Eva Schepers, Griet Glorieux, Wim Van Biesen, Francis Verbeke
Background: Polycystic kidney disease (PKD) is characterized by urinary tract infections and extrarenal abnormalities such as an increased risk of cancer. As mutations in polycystin-1 and -2 are associated with decreased proliferation of immortalized lymphoblastoid cells in PKD, we investigated whether lymphopenia could be an unrecognized trait of PKD. Methods: We studied 700 kidney transplant recipients with ( n  = 126) or without PKD at the time of kidney transplantation between 1 January 2003 and 31 December 2014 at Ghent University Hospital...
April 6, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28382283/protective-effect-of-white-fleshed-peach-prunus-persica-l-batsch-on-chronic-nicotine-induced-toxicity
#10
Hyun-Jeong Kim, Kwang-Kyun Park, Won-Yoon Chung, Sun Kyoung Lee, Ki-Rim Kim
BACKGROUND: Nicotine is a major toxic component of tobacco smoke and has been recognized as a risk factor to induce oxidative tissue damage, which is a precursor to cardiovascular diseases, lung-related diseases, and cancers. Peaches (Prunus persica) have been used for the treatment of degenerative disorders, such as hypermenorrhea, dysmenorrhea, and infertility in Asian countries. In this study, we investigated the effects of white-fleshed peach on the excretion of nicotine metabolites and 1-hydroxypyrene in smokers and chronic nicotine-induced tissue damages in mice...
March 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28382266/impact-of-lifestyle-diseases-on-postoperative-complications-and-survival-in-elderly-patients-with-stage-i-non-small-cell-lung-cancer
#11
Sang Seok Jeong, Pil Jo Choi, Jung Hoon Yi, Sung Sil Yoon
BACKGROUND: The influence of lifestyle diseases on postoperative complications and long-term survival in patients with non-small cell lung cancer (NSCLC) is unclear. The aim of this study was to determine whether lifestyle diseases were significant risk factors of perioperative and long-term surgical outcomes in elderly patients with stage I NSCLC. METHODS: Between December 1995 and November 2013, 110 patients aged 65 years or older who underwent surgical resection of stage I NSCLC at Dong-A University Hospital were retrospectively studied...
April 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28380304/cardiopulmonary-exercise-testing-in-heart-failure-patients-with-specific-comorbidities
#12
Massimo F Piepoli, Ugo Corrà, Piergiuseppe Agostoni
Exercise capacity is one of the most powerful predicting factors of life expectancy, both in patients with and without cardiac disease. Cardiopulmonary exercise testing provides a global assessment of the integrative exercise responses involving the pulmonary, cardiovascular, hematopoietic, neuropsychological, and skeletal muscle systems, which are not adequately reflected through the measurement of individual organ system function. This relatively noninvasive, dynamic, physiologic overview allows the evaluation of both submaximal and peak exercise responses, providing the physician with relevant information for clinical decision making...
April 5, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28373486/diastereomer-specific-quantification-of-bioactive-hexosylceramides-from-bacteria-and-mammals
#13
Johanna von Gerichten, Kerstin Schlosser, Dominic Lamprecht, Ivan Morace, Matthias Eckhardt, Dagmar Wachten, Richard Jennemann, Hermann-Josef Gröne, Matthias Mack, Roger Sandhoff
Mammals synthesize cell-type specifically the diastereomeric hexosylceramides β-galactosylceramide (β-GalCer) and β-glucosylceramide (β-GlcCer), which are involved in several diseases such as sphingolipidosis, diabetes, chronic kidney diseases, or cancer. In contrast Bacteroides fragilis, a member of the human gut microbiome, and the marine sponge Agelas mauritianus produce α-galactosylceramide (α-GalCer), one of the most potent stimulators for iNKT cells. To dissect the contribution of these individual stereoisomers to pathologies, we established a novel HILIC based LC MS(2) method and separate (R > 1...
April 3, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28367534/soluble-urokinase-type-plasminogen-activator-receptor-supar-and-impaired-kidney-function-in-the-population-based-malm%C3%A3-diet-and-cancer-study
#14
Christina-Alexandra Schulz, Margaretha Persson, Anders Christensson, George Hindy, Peter Almgren, Peter M Nilsson, Olle Melander, Gunnar Engström, Marju Orho-Melander
INTRODUCTION: The soluble urokinase-type plasminogen activator receptor (suPAR) has recently been associated with a decline in kidney function and incidence of chronic kidney disease in patients with cardiovascular disease undergoing cardiac catheterization, yet little is known whether suPAR is associated with deterioration of kidney function in the general population. METHODS: In the population-based Malmö Diet and Cancer Study cohort, plasma levels of suPAR were quantified in 5381 participants at baseline (1991-1994), and creatinine was measured and used to calculate estimated glomerulus filtration rate (eGFR) at baseline and follow-up (2007-2012)...
March 2017: KI Reports
https://www.readbyqxmd.com/read/28363473/end-stage-renal-disease-secondary-to-renal-malignancy-epidemiologic-trends-and-survival-outcomes
#15
Kevin A Nguyen, Srinivas Vourganti, Jamil S Syed, Randy Luciano, Steven C Campbell, Brian Shuch
OBJECTIVES: Loss of renal parenchyma after surgery may contribute to chronic kidney disease; however, the long-term consequences of chronic kidney disease may differ by cause. We analyzed the outcomes of patients with end-stage renal disease (ESRD) based on various medical and surgical causes. MATERIALS AND METHODS: In the United States Renal Data System from the period 1983 to 2007, patients with renal tumors, traumatic surgical loss, diabetes, or other known causes were identified...
March 28, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28362263/inhibitor-of-ppgalnac-t3-mediated-o-glycosylation-blocks-cancer-cell-invasiveness-and-lowers-fgf23-levels
#16
Lina Song, Adam Linstedt
Small molecule inhibitors of site-specific O-glycosylation by the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-T) family are currently unavailable but hold promise as therapeutics, especially if selective against individual ppGalNAc-T isozymes. To identify a compound targeting the ppGalNAc-T3 isozyme, we screened libraries to find compounds that act on a cell-based fluorescence sensor of ppGalNAc-T3 but not on a sensor of ppGalNAc-T2. This identified a hit that subsequent in vitro analysis showed directly binds and inhibits purified ppGalNAc-T3 with no detectable activity against either ppGalNAc-T2 or ppGalNAc-T6...
March 31, 2017: ELife
https://www.readbyqxmd.com/read/28361575/obesity-and-kidney-disease-hidden-consequences-of-the-epidemic
#17
C P Kovesdy, S Furth, C Zoccali, World Kidney Day Steering Committee
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease, and also for chronic kidney disease (CKD). A high body mass index is one of the strongest risk factors for new-onset CKD. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing CKD in the long-term...
March 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28356078/calcium-oxalate-crystal-related-kidney-injury-in-a-patient-receiving-roux-en-y-hepaticojejunostomy-due-to-gall-bladder-cancer
#18
Jun-Li Tsai, Shang-Feng Tsai
BACKGROUND: Calcium oxalate nephropathy is rare in current practice. It was a common complication during jejunoileal bypass, but much less seen in modern gastric bypass surgery for morbid obesity. The major cause of it is enteric hyperoxaluria. CASE PRESENTATION: We report on a patient here with acute kidney disease due to calcium oxalate nephropathy, rather than the conditions mentioned above. The male patient received a Roux-en Y hepaticojejunostomy and common bile duct drainage...
March 29, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28355410/obesity-and-kidney-disease-hidden-consequences-of-the-epidemic
#19
Csaba P Kovesdy, Susan L Furth, Carmine Zoccali
Obesity has become a worldwide epidemic, and its prevalence has been projected to grow by 40% in the next decade. This increasing prevalence has implications for the risk of diabetes, cardiovascular disease and also for Chronic Kidney Disease. A high body mass index is one of the strongest risk factors for new-onset Chronic Kidney Disease. In individuals affected by obesity, a compensatory hyperfiltration occurs to meet the heightened metabolic demands of the increased body weight. The increase in intraglomerular pressure can damage the kidneys and raise the risk of developing Chronic Kidney Disease in the long-term...
March 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28353062/self-reported-long-term-cardiac-morbidity-in-breast-cancer-patients-a-retrospective-cohort-study-in-germany-passos-heart-study
#20
Daniel Wollschläger, Hiltrud Merzenich, Lukas Schwentner, Wolfgang Janni, Thomas Wiegel, Detlef Bartkowiak, Achim Wöckel, Marcus Schmidt, Heinz Schmidberger, Maria Blettner
PURPOSE: Improved survival after locoregional breast cancer has increased the concern about late adverse effects after therapy. In particular, radiotherapy was identified as a risk factor for major cardiac events in women treated until the 1990s. While modern radiotherapy with computerized planning based on 3D-imaging can help spare organs at risk, heart exposure may remain substantial. In a retrospective cohort study of women treated for locoregional breast cancer, we investigated whether current radiotherapy is associated with an elevated long-term cardiac morbidity risk...
March 28, 2017: Breast Cancer Research and Treatment
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