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Keywords neuron specific enolase and ep...

neuron specific enolase and epilepsy

https://read.qxmd.com/read/31526644/acute-symptomatic-seizures-and-epilepsy-after-mechanical-thrombectomy
#21
JOURNAL ARTICLE
Hanna Eriksson, Pia Löwhagen Hendén, Alexandros Rentzos, Fani Pujol-Calderón, Jan-Erik Karlsson, Kina Höglund, Kaj Blennow, Henrik Zetterberg, Lars Rosengren, Johan Zelano
PURPOSE: The purpose of this study was to assess the incidence of acute symptomatic seizures and poststroke epilepsy (PSE) in a well-characterized cohort of patients treated with mechanical thrombectomy. In addition, we aimed to describe the dynamics of blood markers of brain injury in patients that developed PSE. METHODS: Participants of the prospective AnStroke Trial of anesthesia method during mechanical thrombectomy were included and acute symptomatic seizures and PSE ascertained by medical records review...
September 13, 2019: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/31309031/rare-case-of-anti-lgi1-limbic-encephalitis-with-new-onset-epilepsy-a-case-report
#22
Mohan Kurukumbi, Jose A Castillo, Tulsi Shah, Rajesh Gupta
Anti-leucine-rich glioma-inactivated 1 (LGI1) limbic encephalitis (LE) has been classified as an autoimmune LE with a subacute course. Many patients with anti-LGI1 LE have normal or minimal cerebrospinal fluid (CSF) findings. Cerebrospinal fluid 14-3-3 protein or neuron specific enolase is usually seen in Creutzfeldt-Jakob disease (CJD) with high sensitivities, but can also be positive in other paraneoplastic and autoimmune encephalitides, which can make diagnosis challenging. The mainstay of treatment for anti-LGI1 LE generally focuses on steroids, intravenous immunoglobulin (IVIG), plasmapheresis, and/or rituximab...
May 7, 2019: Curēus
https://read.qxmd.com/read/30860117/neuroprotective-role-of-dexmedetomidine-in-epilepsy-surgery-a-preliminary-study
#23
JOURNAL ARTICLE
Ashish Bindra, Ashutosh Kaushal, Hemanshu Prabhakar, Arvind Chaturvedi, Poodepedi Sarat Chandra, Manjari Tripathi, Vivekanandan Subbiah, Sandeep Sathianathan, Jyotirmoy Banerjee, Chander Prakash
Purpose: Long standing temporal lobe epilepsy (TLE) causes cerebral insult and results in elevated brain injury biomarkers, S100b and neuron specific enolase (NSE). Surgery for TLE, has the potential to cause additional cerebral insult. Dexmedetomidine is postulated to have neuroprotective effects. The aim of this study was to assess the effect of intraoperative dexmedetomidine on S100b and NSE during TLE surgery. Materials and Methods: 19 consenting adult patients with TLE undergoing anteromedial temporal lobectomy were enrolled and divided into two groups...
January 2019: Neurology India
https://read.qxmd.com/read/30181529/modulation-of-p2x-purinoceptor-3-p2x3-in-pentylenetetrazole-induced-kindling-epilepsy-in-rats
#24
JOURNAL ARTICLE
Jie Xia, Hui Wang, Qimei Zhang, Zhongmou Han
BACKGROUND Epilepsy is a complex neurologic disorder with abnormal electrical impulses in the brain. A crucial role of purinergic signalling in the proper working of the nervous system has been reported but much less is known about the modulation of P2X3 purinergic receptors in epilepsy. This study investigated the effect of NF110, a potent P2X3 receptor antagonist, in the rat epilepsy model of pentylenetetrazole (PTZ)-induced kindling. MATERIAL AND METHODS The mean kindling score, motor activity, locomotion, emotional tension, anxiety, discrimination ability, learning, memory, serum neuron-specific enolase (sNSE), hippocampal IL-1β and TNF-α, thiobarbituric acid-reactive substance (TBARS), catalase (CAT) and reduced glutathione (GSH), and mitochondrial complex I, II, and IV levels of PTZ-kindling animals were assessed...
September 5, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/29039551/upregulation-of-rho7-in-the-temporal-lobe-tissue-of-humans-with-intractable-epilepsy
#25
JOURNAL ARTICLE
Xinglong Yang, Baiyuan Yang, Haonan Li, Hui Ren
Patients with intractable epilepsy (IE) exhibit an increased risk of premature death, psychosocial dysfunction and decreasing quality of life. The present study aimed to investigate the alteration in the expression of Rho7 in brain tissue from patients with IE, and to examine the association between Rho7 protein expression and IE. Temporal lobe samples were collected from the temporal lobes of 33 patients with IE patients and 10 age‑ and gender‑matched histologically healthy controls. Immunohistochemical staining was conducted to assess the number of Rho7‑positive cells...
December 2017: Molecular Medicine Reports
https://read.qxmd.com/read/29028517/effect-of-carbamazepine-and-oxcarbazepine-on-serum-neuron-specific-enolase-in-focal-seizures-a-randomized-controlled-trial
#26
RANDOMIZED CONTROLLED TRIAL
Rituparna Maiti, Biswa Ranjan Mishra, Soham Sanyal, Debadatta Mohapatra, Sansita Parida, Archana Mishra
Neuron-specific enolase (NSE) is the most investigated biomarker in the context of epilepsy and brain damage. The present study was conducted to investigate the change in serum NSE in patients with focal seizure and the effect of carbamazepine and oxcarbazepine on serum NSE. The present study is a randomized, open-label, parallel design clinical trial (ClinicalTrials.gov Identifier: NCT02705768) conducted on 60 patients of focal seizure. After recruitment, detailed history, clinical evaluations including Chalfont-National Hospital seizure severity scale (NHS3), Quality of Life in Epilepsy Inventory (QOLIE-31) and serum NSE estimation were done at baseline...
December 2017: Epilepsy Research
https://read.qxmd.com/read/28236069/cerebrospinal-fluid-neuron-specific-enolase-interleukin-1%C3%AE-and-erythropoietin-concentrations-in-children-after-seizures
#27
JOURNAL ARTICLE
Ling-Min Shi, Rui-Jie Chen, Hui Zhang, Chun-Ming Jiang, Jian Gong
PURPOSE: In the present study, the levels of neuron-specific enolase (NSE), interleukin-1β (IL-1β), and erythropoietin (EPO) in cerebrospinal fluid (CSF) in children with idiopathic epilepsy were measured to illuminate the relationships between these markers with idiopathic epilepsy. METHODS: Eighty-five children from 6 months to 12.5 years of age with single, previously undiagnosed, and untreated idiopathic epilepsy were participated in this study. The concentrations of CSF NSE, 1L-1β, and EPO were measured by specific ELISA methods...
May 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/27793866/dementia-epilepsy-and-polyneuropathy-in-a-mercury-exposed-patient-investigation-identification-of-an-obscure-source-and-treatment
#28
JOURNAL ARTICLE
Tobias Zellner, Nicolas Zellner, Norbert Felgenhauer, Florian Eyer
We present a patient aged 54 years with early onset of dementia, epilepsy and peripheral polyneuropathy. A mercury intoxication was diagnosed in 2010, chelation therapy with 2,3-dimercaptopropane-1-sulfonate had failed. A source of exposure could not be identified. MRI showed unspecific hyperintense brain lesions in 2015. She was referred for diagnosis and treatment. Neuropsychological testing indicated severe memory loss and nerve conduction speed measurements showed chronic neurogenically changed potentials...
October 28, 2016: BMJ Case Reports
https://read.qxmd.com/read/25625088/anti-kindling-effect-of-bezafibrate-a-peroxisome-proliferator-activated-receptors-alpha-agonist-in-pentylenetetrazole-induced-kindling-seizure-model
#29
JOURNAL ARTICLE
Lekha Saha, Swati Bhandari, Alka Bhatia, Dibyajyoti Banerjee, Amitava Chakrabarti
BACKGROUND AND PURPOSE: Studies in the animals suggested that Peroxisome proliferators activated receptors (PPARs) may be involved in seizure control and selective agonists of PPAR α or PPAR γ raise seizure thresholds. The present study was contemplated with the aim of evaluating the anti kindling effects and the mechanism of bezafibrate, a Peroxisome proliferator-activated receptors α (PPAR-α) agonist in pentylenetetrazole (PTZ) induced kindling model of seizures in rats. METHODS: In a PTZ kindled Wistar rat model, different doses of bezafibrate (100 mg/kg, 200 mg/kg and 300 mg/kg) were administered intraperitoneally 30 minutes before the PTZ injection...
December 2014: Journal of Epilepsy Research
https://read.qxmd.com/read/24399476/-tetraplegia-resuscitation-and-epileptic-seizures-after-partial-colon-resection-in-a-41-year-old-woman
#30
JOURNAL ARTICLE
W Wagner
A 41-year-old woman, suffering from continuous abdominal pain, only presented a non-specific inflammation of the whole colon and an unclaryfied hyponatriaemia; in spite of the only doubtful explanation by an enormous elongation of the colon, it was partially resected. Thereafter, the patient's decline, hypaesthesia, areflexia and tetraparesis required intensive care. Despite immunoglobulin therapy, assuming a Guillain-Barré syndrome, the patient needed resuscitation, followed by signs of severe hypoxia (high level of neuron-specific enolase, hippocampal lesions)...
January 2014: Der Internist
https://read.qxmd.com/read/24397543/erythropoietin-pretreatment-suppresses-seizures-and-prevents-the-increase-in-inflammatory-mediators-during-pentylenetetrazole-induced-generalized-seizures
#31
JOURNAL ARTICLE
Nesrin Bahçekapılı, Kadriye Akgün-Dar, Işıl Albeniz, Ayşegül Kapucu, Aslı Kandil, Orhan Yağız, Gülay Üzüm
Erythropoietin (EPO) suppresses epileptic seizures, but the mechanism is unclear. The search for novel targets in the therapy of epilepsy has focused recently on brain inflammation since brain inflammation and the associated blood-brain barrier (BBB) damage appears to be an integral part of epilepsy pathophysiology. We examined the effects of EPO on proinflammatory mediators in brain and serum in PTZ-induced generalized seizure model. The inflammation markers (IL-1β, TNF-α, IL-6, IL-10), BBB and neuron damage markers (S100B, Neuron specific enolase; NSE, respectively) in serum and brain of Sprague-Dawley male rats were examined with the ELISA method...
October 2014: International Journal of Neuroscience
https://read.qxmd.com/read/23637882/intervention-effects-of-ganoderma-lucidum-spores-on-epileptiform-discharge-hippocampal-neurons-and-expression-of-neurotrophin-4-and-n-cadherin
#32
JOURNAL ARTICLE
Shu-Qiu Wang, Xiao-Jie Li, Shaobo Zhou, Di-Xiang Sun, Hui Wang, Peng-Fei Cheng, Xiao-Ru Ma, Lei Liu, Jun-Xing Liu, Fang-Fang Wang, Yan-Feng Liang, Jia-Mei Wu
Epilepsy can cause cerebral transient dysfunctions. Ganoderma lucidum spores (GLS), a traditional Chinese medicinal herb, has shown some antiepileptic effects in our previous studies. This was the first study of the effects of GLS on cultured primary hippocampal neurons, treated with Mg(2+) free medium. This in vitro model of epileptiform discharge hippocampal neurons allowed us to investigate the anti-epileptic effects and mechanism of GLS activity. Primary hippocampal neurons from <1 day old rats were cultured and their morphologies observed under fluorescence microscope...
2013: PloS One
https://read.qxmd.com/read/23587436/clinical-biochemical-and-neuroimaging-findings-predict-long-term-neurodevelopmental-outcome-in-symptomatic-congenital-cytomegalovirus-infection
#33
JOURNAL ARTICLE
Ana Alarcon, Miriam Martinez-Biarge, Fernando Cabañas, Angel Hernanz, Jose Quero, Alfredo Garcia-Alix
OBJECTIVE: To evaluate clinical, biochemical, and neuroimaging findings as predictors of neurodevelopmental outcome in patients with symptomatic congenital cytomegalovirus (CMV). STUDY DESIGN: The study cohort comprised 26 patients with symptomatic congenital CMV born between 1993 and 2009 in a single center. Absolute and weight deficit-adjusted head circumference were considered. Cerebrospinal fluid (CSF) investigations included standard cytochemical analysis, determination of beta2-microglobulin (β2-m), neuron-specific enolase, and CMV DNA detection...
September 2013: Journal of Pediatrics
https://read.qxmd.com/read/23406753/level-of-s100b-protein-neuron-specific-enolase-orexin-a-adiponectin-and-insulin-like-growth-factor-in-serum-of-pediatric-patients-suffering-from-sleep-disorders-with-or-without-epilepsy
#34
COMPARATIVE STUDY
Marek Kaciński, Bogusława Budziszewska, Władysław Lasoń, Anna Zając, Barbara Skowronek-Bała, Monika Leśkiewicz, Alicja Kubik, Agnieszka Basta-Kaim
BACKGROUND: Paroxysmal sleep disorders in children are important from both pathophysiological and clinical point of view. Correct diagnosis is crucial for further management. The aim of the present study was to identify peripheral markers of paroxysmal sleep disorders in children, which could improve diagnostics of these disorders. We compared serum levels of several putative biomarkers of neurological disorders, such as S100B protein, neuron specific enolase (NSE), orexin A, adiponectin, and insulin-like growth factor 1 (IGF-1) in pediatric patients suffering from sleep disturbances with those who additionally to parasomnia revealed also epilepsy...
2012: Pharmacological Reports: PR
https://read.qxmd.com/read/23163590/variability-in-diagnosing-creutzfeldt-jakob-disease-using-standard-and-proposed-diagnostic-criteria
#35
COMPARATIVE STUDY
C R Newey, A Sarwal, D Wisco, S Alam, R J Lederman
INTRODUCTION: Creutzfeldt-Jakob disease (CJD) is a rapidly progressive dementia with a median survival of 2-14 months. The diagnosis can only be made accurately by biopsy/autopsy. However, this is not always feasible or desirable. Thus, diagnostic criteria have been proposed by UCSF, European MRI-CJD Consortium, and WHO. We will compare these criteria. PATIENTS AND METHODS: Retrospective study of 31 patients (average age of 69.2 years) between 2003 to 2010 by ICD9 codes 046...
January 2013: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://read.qxmd.com/read/22521826/functional-recovery-and-neuronal-regeneration-of-a-rat-model-of-epilepsy-by-transplantation-of-hes1-down-regulated-bone-marrow-stromal-cells
#36
JOURNAL ARTICLE
Q Long, B Qiu, W Liu, Z Fei, G Feng, P Wang, J Zhong, X Yi, Y Liu, Y Zhang, R Han
Gamma-amino butyric acid (GABA)ergic cells play an important inhibitory role in epilepsy. Until now, there are no reports on promoting transplanted bone marrow stromal cells (BMSCs) to differentiate into GABAergic cells for treatment of epilepsy. In this study, hairy and enhancer of split 1 (Hes1)-down regulated BMSCs (H-BMSCs) were transplanted into an epileptic rat model to induce GABAergic cells differentiation to improve the function recovery and neuronal regeneration. First, Hes1 expression in isolated BMSCs was down regulated by Hes1 siRNA...
June 14, 2012: Neuroscience
https://read.qxmd.com/read/22417223/clinical-significance-of-serological-biomarkers-and-neuropsychological-performances-in-patients-with-temporal-lobe-epilepsy
#37
JOURNAL ARTICLE
Chiung-Chih Chang, Chun-Chung Lui, Chen-Chang Lee, Shang-Der Chen, Wen-Neng Chang, Cheng-Hsien Lu, Nai-Ching Chen, Alice Y W Chang, Samuel H H Chan, Yao-Chung Chuang
BACKGROUND: Temporal lobe epilepsy (TLE) is a common form of focal epilepsy. Serum biomarkers to predict cognitive performance in TLE patients without psychiatric comorbidities and the link with gray matter (GM) atrophy have not been fully explored. METHODS: Thirty-four patients with TLE and 34 sex - and age-matched controls were enrolled for standardized cognitive tests, neuroimaging studies as well as measurements of serum levels of heat shock protein 70 (HSP70), S100ß protein (S100ßP), neuronal specific enolase (NSE), plasma nuclear and mitochondrial DNA levels...
2012: BMC Neurology
https://read.qxmd.com/read/22070383/investigating-the-role-of-zinc-in-a-rat-model-of-epilepsy
#38
COMPARATIVE STUDY
A M Baraka, W Hassab El Nabi, S El Ghotni
AIMS: The aim of the present study was to investigate the role of zinc (Zn) in pilocarpine-induced seizures and its interrelation with an antiepileptic drug, namely, valproic acid. METHODOLOGY: The study was carried out on 110 male Wistar albino rats that were divided into the following groups: Group I, control rats that received intraperitoneal (i.p.) saline vehicle; Groups II-V received Zn in a medium dose, Zn in a high dose, valproic acid in a therapeutic dose, as well as a combination of valproic acid with medium dose Zn, respectively, for 3 weeks before saline injection, Group VI received i...
April 2012: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/21647847/acute-encephalopathy-in-a-patient-with-dravet-syndrome
#39
JOURNAL ARTICLE
M Tsuji, E Mazaki, I Ogiwara, T Wada, M Iai, A Okumura, S Yamashita, K Yamakawa, H Osaka
Dravet syndrome (severe myoclonic epilepsy in infancy) is an epileptic syndrome with various types of seizures that begin in the first year of life and may result in intellectual impairment. Mutations of the SCN1A gene are the most prevalent genetic cause of Dravet syndrome. In this study, we report a 12-year-old girl with Dravet syndrome carrying an SCN1A mutation, c.2785Cdel (L929del fsX934). She had an episode of status epilepticus and persistent lethargy after 48 h of acute febrile illness that was preceded by an annual flu vaccination...
February 2011: Neuropediatrics
https://read.qxmd.com/read/21638339/expression-pattern-of-mical-1-in-the-temporal-neocortex-of-patients-with-intractable-temporal-epilepsy-and-pilocarpine-induced-rat-model
#40
COMPARATIVE STUDY
Jing Luo, Yali Xu, Qiong Zhu, Fenghua Zhao, Ying Zhang, Xi Peng, Wei Wang, Xuefeng Wang
Mical-1 is a novel F-actin-disassembly factor that is critical in actin reorganization. It provides a molecular conduit through which actin reorganizes-a hallmark of cell morphological changes, including axon navigation. However, whether Mical-1 is involved in the epileptogenesis remains unknown. Here, we investigate Mical-1 expression pattern in patients with intractable temporal lobe epilepsy (TLE) and pilocarpine-induced rat model. We used double-labeled immunoflurescence, immunohistochemistry, and Western blotting to assess the location and expression of Mical-1 in temporal neocortex of patients with intractable TLE, and the expression pattern of Mical-1 at different time point in the hippocampus and temporal lobe cortex of the pilocarpine-induced rat model...
November 2011: Synapse
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