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neuron specific enolase and epilepsy

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https://www.readbyqxmd.com/read/27793866/dementia-epilepsy-and-polyneuropathy-in-a-mercury-exposed-patient-investigation-identification-of-an-obscure-source-and-treatment
#1
Tobias Zellner, Nicolas Zellner, Norbert Felgenhauer, Florian Eyer
We present a patient aged 54 years with early onset of dementia, epilepsy and peripheral polyneuropathy. A mercury intoxication was diagnosed in 2010, chelation therapy with 2,3-dimercaptopropane-1-sulfonate had failed. A source of exposure could not be identified. MRI showed unspecific hyperintense brain lesions in 2015. She was referred for diagnosis and treatment. Neuropsychological testing indicated severe memory loss and nerve conduction speed measurements showed chronic neurogenically changed potentials...
October 28, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/25625088/anti-kindling-effect-of-bezafibrate-a-peroxisome-proliferator-activated-receptors-alpha-agonist-in-pentylenetetrazole-induced-kindling-seizure-model
#2
Lekha Saha, Swati Bhandari, Alka Bhatia, Dibyajyoti Banerjee, Amitava Chakrabarti
BACKGROUND AND PURPOSE: Studies in the animals suggested that Peroxisome proliferators activated receptors (PPARs) may be involved in seizure control and selective agonists of PPAR α or PPAR γ raise seizure thresholds. The present study was contemplated with the aim of evaluating the anti kindling effects and the mechanism of bezafibrate, a Peroxisome proliferator-activated receptors α (PPAR-α) agonist in pentylenetetrazole (PTZ) induced kindling model of seizures in rats. METHODS: In a PTZ kindled Wistar rat model, different doses of bezafibrate (100 mg/kg, 200 mg/kg and 300 mg/kg) were administered intraperitoneally 30 minutes before the PTZ injection...
December 2014: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/24399476/-tetraplegia-resuscitation-and-epileptic-seizures-after-partial-colon-resection-in-a-41-year-old-woman
#3
W Wagner
A 41-year-old woman, suffering from continuous abdominal pain, only presented a non-specific inflammation of the whole colon and an unclaryfied hyponatriaemia; in spite of the only doubtful explanation by an enormous elongation of the colon, it was partially resected. Thereafter, the patient's decline, hypaesthesia, areflexia and tetraparesis required intensive care. Despite immunoglobulin therapy, assuming a Guillain-Barré syndrome, the patient needed resuscitation, followed by signs of severe hypoxia (high level of neuron-specific enolase, hippocampal lesions)...
January 2014: Der Internist
https://www.readbyqxmd.com/read/24397543/erythropoietin-pretreatment-suppresses-seizures-and-prevents-the-increase-in-inflammatory-mediators-during-pentylenetetrazole-induced-generalized-seizures
#4
Nesrin Bahçekapılı, Kadriye Akgün-Dar, Işıl Albeniz, Ayşegül Kapucu, Aslı Kandil, Orhan Yağız, Gülay Üzüm
Erythropoietin (EPO) suppresses epileptic seizures, but the mechanism is unclear. The search for novel targets in the therapy of epilepsy has focused recently on brain inflammation since brain inflammation and the associated blood-brain barrier (BBB) damage appears to be an integral part of epilepsy pathophysiology. We examined the effects of EPO on proinflammatory mediators in brain and serum in PTZ-induced generalized seizure model. The inflammation markers (IL-1β, TNF-α, IL-6, IL-10), BBB and neuron damage markers (S100B, Neuron specific enolase; NSE, respectively) in serum and brain of Sprague-Dawley male rats were examined with the ELISA method...
October 2014: International Journal of Neuroscience
https://www.readbyqxmd.com/read/23637882/intervention-effects-of-ganoderma-lucidum-spores-on-epileptiform-discharge-hippocampal-neurons-and-expression-of-neurotrophin-4-and-n-cadherin
#5
Shu-Qiu Wang, Xiao-Jie Li, Shaobo Zhou, Di-Xiang Sun, Hui Wang, Peng-Fei Cheng, Xiao-Ru Ma, Lei Liu, Jun-Xing Liu, Fang-Fang Wang, Yan-Feng Liang, Jia-Mei Wu
Epilepsy can cause cerebral transient dysfunctions. Ganoderma lucidum spores (GLS), a traditional Chinese medicinal herb, has shown some antiepileptic effects in our previous studies. This was the first study of the effects of GLS on cultured primary hippocampal neurons, treated with Mg(2+) free medium. This in vitro model of epileptiform discharge hippocampal neurons allowed us to investigate the anti-epileptic effects and mechanism of GLS activity. Primary hippocampal neurons from <1 day old rats were cultured and their morphologies observed under fluorescence microscope...
2013: PloS One
https://www.readbyqxmd.com/read/23587436/clinical-biochemical-and-neuroimaging-findings-predict-long-term-neurodevelopmental-outcome-in-symptomatic-congenital-cytomegalovirus-infection
#6
Ana Alarcon, Miriam Martinez-Biarge, Fernando Cabañas, Angel Hernanz, Jose Quero, Alfredo Garcia-Alix
OBJECTIVE: To evaluate clinical, biochemical, and neuroimaging findings as predictors of neurodevelopmental outcome in patients with symptomatic congenital cytomegalovirus (CMV). STUDY DESIGN: The study cohort comprised 26 patients with symptomatic congenital CMV born between 1993 and 2009 in a single center. Absolute and weight deficit-adjusted head circumference were considered. Cerebrospinal fluid (CSF) investigations included standard cytochemical analysis, determination of beta2-microglobulin (β2-m), neuron-specific enolase, and CMV DNA detection...
September 2013: Journal of Pediatrics
https://www.readbyqxmd.com/read/23406753/level-of-s100b-protein-neuron-specific-enolase-orexin-a-adiponectin-and-insulin-like-growth-factor-in-serum-of-pediatric-patients-suffering-from-sleep-disorders-with-or-without-epilepsy
#7
COMPARATIVE STUDY
Marek Kaciński, Bogusława Budziszewska, Władysław Lasoń, Anna Zając, Barbara Skowronek-Bała, Monika Leśkiewicz, Alicja Kubik, Agnieszka Basta-Kaim
BACKGROUND: Paroxysmal sleep disorders in children are important from both pathophysiological and clinical point of view. Correct diagnosis is crucial for further management. The aim of the present study was to identify peripheral markers of paroxysmal sleep disorders in children, which could improve diagnostics of these disorders. We compared serum levels of several putative biomarkers of neurological disorders, such as S100B protein, neuron specific enolase (NSE), orexin A, adiponectin, and insulin-like growth factor 1 (IGF-1) in pediatric patients suffering from sleep disturbances with those who additionally to parasomnia revealed also epilepsy...
2012: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/23163590/variability-in-diagnosing-creutzfeldt-jakob-disease-using-standard-and-proposed-diagnostic-criteria
#8
C R Newey, A Sarwal, D Wisco, S Alam, R J Lederman
INTRODUCTION: Creutzfeldt-Jakob disease (CJD) is a rapidly progressive dementia with a median survival of 2-14 months. The diagnosis can only be made accurately by biopsy/autopsy. However, this is not always feasible or desirable. Thus, diagnostic criteria have been proposed by UCSF, European MRI-CJD Consortium, and WHO. We will compare these criteria. PATIENTS AND METHODS: Retrospective study of 31 patients (average age of 69.2 years) between 2003 to 2010 by ICD9 codes 046...
January 2013: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/22521826/functional-recovery-and-neuronal-regeneration-of-a-rat-model-of-epilepsy-by-transplantation-of-hes1-down-regulated-bone-marrow-stromal-cells
#9
Q Long, B Qiu, W Liu, Z Fei, G Feng, P Wang, J Zhong, X Yi, Y Liu, Y Zhang, R Han
Gamma-amino butyric acid (GABA)ergic cells play an important inhibitory role in epilepsy. Until now, there are no reports on promoting transplanted bone marrow stromal cells (BMSCs) to differentiate into GABAergic cells for treatment of epilepsy. In this study, hairy and enhancer of split 1 (Hes1)-down regulated BMSCs (H-BMSCs) were transplanted into an epileptic rat model to induce GABAergic cells differentiation to improve the function recovery and neuronal regeneration. First, Hes1 expression in isolated BMSCs was down regulated by Hes1 siRNA...
June 14, 2012: Neuroscience
https://www.readbyqxmd.com/read/22417223/clinical-significance-of-serological-biomarkers-and-neuropsychological-performances-in-patients-with-temporal-lobe-epilepsy
#10
Chiung-Chih Chang, Chun-Chung Lui, Chen-Chang Lee, Shang-Der Chen, Wen-Neng Chang, Cheng-Hsien Lu, Nai-Ching Chen, Alice Y W Chang, Samuel H H Chan, Yao-Chung Chuang
BACKGROUND: Temporal lobe epilepsy (TLE) is a common form of focal epilepsy. Serum biomarkers to predict cognitive performance in TLE patients without psychiatric comorbidities and the link with gray matter (GM) atrophy have not been fully explored. METHODS: Thirty-four patients with TLE and 34 sex - and age-matched controls were enrolled for standardized cognitive tests, neuroimaging studies as well as measurements of serum levels of heat shock protein 70 (HSP70), S100ß protein (S100ßP), neuronal specific enolase (NSE), plasma nuclear and mitochondrial DNA levels...
2012: BMC Neurology
https://www.readbyqxmd.com/read/22070383/investigating-the-role-of-zinc-in-a-rat-model-of-epilepsy
#11
COMPARATIVE STUDY
A M Baraka, W Hassab El Nabi, S El Ghotni
AIMS: The aim of the present study was to investigate the role of zinc (Zn) in pilocarpine-induced seizures and its interrelation with an antiepileptic drug, namely, valproic acid. METHODOLOGY: The study was carried out on 110 male Wistar albino rats that were divided into the following groups: Group I, control rats that received intraperitoneal (i.p.) saline vehicle; Groups II-V received Zn in a medium dose, Zn in a high dose, valproic acid in a therapeutic dose, as well as a combination of valproic acid with medium dose Zn, respectively, for 3 weeks before saline injection, Group VI received i...
April 2012: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/21647847/acute-encephalopathy-in-a-patient-with-dravet-syndrome
#12
M Tsuji, E Mazaki, I Ogiwara, T Wada, M Iai, A Okumura, S Yamashita, K Yamakawa, H Osaka
Dravet syndrome (severe myoclonic epilepsy in infancy) is an epileptic syndrome with various types of seizures that begin in the first year of life and may result in intellectual impairment. Mutations of the SCN1A gene are the most prevalent genetic cause of Dravet syndrome. In this study, we report a 12-year-old girl with Dravet syndrome carrying an SCN1A mutation, c.2785Cdel (L929del fsX934). She had an episode of status epilepticus and persistent lethargy after 48 h of acute febrile illness that was preceded by an annual flu vaccination...
February 2011: Neuropediatrics
https://www.readbyqxmd.com/read/21638339/expression-pattern-of-mical-1-in-the-temporal-neocortex-of-patients-with-intractable-temporal-epilepsy-and-pilocarpine-induced-rat-model
#13
COMPARATIVE STUDY
Jing Luo, Yali Xu, Qiong Zhu, Fenghua Zhao, Ying Zhang, Xi Peng, Wei Wang, Xuefeng Wang
Mical-1 is a novel F-actin-disassembly factor that is critical in actin reorganization. It provides a molecular conduit through which actin reorganizes-a hallmark of cell morphological changes, including axon navigation. However, whether Mical-1 is involved in the epileptogenesis remains unknown. Here, we investigate Mical-1 expression pattern in patients with intractable temporal lobe epilepsy (TLE) and pilocarpine-induced rat model. We used double-labeled immunoflurescence, immunohistochemistry, and Western blotting to assess the location and expression of Mical-1 in temporal neocortex of patients with intractable TLE, and the expression pattern of Mical-1 at different time point in the hippocampus and temporal lobe cortex of the pilocarpine-induced rat model...
November 2011: Synapse
https://www.readbyqxmd.com/read/21482234/-psychogenic-non-epileptic-seizures-a-review
#14
REVIEW
Y Auxéméry, C Hubsch, G Fidelle
OBJECTIVE: This paper summarizes the recent literature on the phenomena of psychogenic non epileptic seizures (PNES). DEFINITION AND EPIDEMIOLOGY: PNES are, as altered movement, sensation or experience, similar to epilepsy, but caused by a psychological process. Although in the ICD-10, PNES belong to the group of dissociative disorders, they are classified as somatoform disorders in the DSM-IV. That represents a challenging diagnosis: the mean latency between manifestations and diagnosis remains as long as 7 years...
April 2011: L'Encéphale
https://www.readbyqxmd.com/read/21432772/increased-expression-of-annexin-a7-in-temporal-lobe-tissue-of-patients-with-refractory-epilepsy
#15
Sheng-nian Zhou, Cheng-shan Li, Li-qing Liu, Yan Li, Xue-feng Wang, Lan Shen
Annexin A7 is a member of the family of annexins, which are thought to function in the regulation of calcium homeostasis and the fusion of vesicles. Refractory epilepsy may be related to the imbalance of calcium homeostasis. Our aims are to investigate the expression of Annexin A7 in epileptic brains in comparison with human controls and to explore Annexin A7's possible role in refractory epilepsy. We examined the expression of Annexin A7 via immunohistochemistry, double-label immunofluorescence and western blot...
May 2011: Histology and Histopathology
https://www.readbyqxmd.com/read/21293918/elevated-s100b-and-neuron-specific-enolase-levels-in-patients-with-migraine-without-aura-evidence-for-neurodegeneration
#16
Nurgul Yilmaz, Kamil Karaali, Sebahat Ozdem, Mehtap Turkay, Ali Unal, Babur Dora
Although migraine has mainly been considered as a benign disease, there is cumulative evidence of silent changes in the brain, brainstem, or cerebellum and subtle subclinical cerebellar dysfunction. In this study, in order to investigate a possible neuronal and/or glial damage at the cellular level in migraine, we measured and compared serum levels of S100B which is a protein marker of glial damage or activation, and neuron specific enolase (NSE) which is a marker of neuronal damage, in migraine patients and control subjects...
May 2011: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/21081112/evaluating-reference-genes-to-normalize-gene-expression-in-human-epileptogenic-brain-tissues
#17
Stephan Wierschke, Sylvain Gigout, Peter Horn, Thomas-Nicolas Lehmann, Christoph Dehnicke, Anja U Bräuer, Rudolf A Deisz
Several reference genes have been used to quantify gene expression in human epilepsy surgery tissue. However, their reliability has not been validated in detail, although this is crucial in interpreting epilepsy-related changes of gene expression. We evaluated 12 potential reference genes in neocortical tissues resected from patients with temporal lobe epilepsy (TLE) with either few or many seizures (n=6 each) and post mortem controls (n=6) using geNorm and NormFinder algorithms. For all candidate reference genes threshold cycle (C(T)) values were measured...
December 17, 2010: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/21077993/new-insights-into-the-pathogenesis-of-perinatal-hypoxic-ischemic-brain-injury
#18
Brankica Vasiljevic, Svjetlana Maglajlic-Djukic, Miroslava Gojnic, Sanja Stankovic, Svetlana Ignjatovic, Dragana Lutovac
BACKGROUND: Pathogenesis of perinatal hypoxic-ischemic brain injury (HIE) is complex. In this study, we examined the role of neuroinflammation, oxidative stress and growth factors in perinatal hypoxic-ischemic brain damage. METHODS: Ninety neonates (>32 weeks' gestation) with perinatal HIE were enrolled prospectively. Perinatal HIE was categorized into three stages according to the Sarnat and Sarnat clinical scoring system and changes seen on amplitude integrated electroencephalography...
August 2011: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/21034558/expression-and-localization-of-annexin-a7-in-the-rat-lithium-pilocarpine-model-of-acquired-epilepsy
#19
Sheng-nian Zhou, Cheng-shan Li, Li-qing Liu, Lan Shen, Yan Li
BACKGROUND: Annexin A7 (synexin, ANXA7) is a member of annexins, which plays an essential role in the regulation of calcium homeostasis. Considerable evidence shows that the pathogenetic mechanism of acquired epilepsy (AE) has been related to the imbalance of calcium homeostasis. The aim of this study was to investigate ANXA7 expression and cellular localization in the cortex and hippocampus in the rat lithium-pilocarpine model of AE. METHODS: Totally 81 adult healthy male Wistar rats were randomly divided into control group (n = 9) and experimental group (n = 72), the experimental group contained eight subgroups according to sacrifice time (n = 9) (6-hour, 24-hour, 48-hour, 72-hour, 7-day, 15-day, 1-month, and 2-month)...
September 2010: Chinese Medical Journal
https://www.readbyqxmd.com/read/20696621/hormonal-alterations-following-seizures
#20
REVIEW
Gerhard Luef
Postictal increases in prolactin (PRL), luteinizing hormone, and follicle-stimulating hormone have been recorded in patients with both generalized tonic-clonic and partial seizures. Elevations of PRL and luteinizing hormone were seen immediately and at 20 minutes after generalized tonic-clonic seizures in male and female patients. Usually, PRL blood levels return to normal values within 1 hour. Previous studies have evaluated the utility of the transient increases in PRL, neuron-specific enolase, and S-100 protein as markers of epileptic seizures in children and adults...
October 2010: Epilepsy & Behavior: E&B
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