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Cornea pannus

Elias Flockerzi, Loay Daas, Ursula Schlötzer-Schrehardt, Annette Zimpfer, Rainer Bohle, Berthold Seitz
PURPOSE: Cystinosis is an autosomal recessive inherited lysosomal storage disease with an incidence of 1:100.000 up to 1:200.000 caused by a gene mutation of a lysosomal transport protein resulting in deposition of cystine in lysosomes in all cells and tissues. In the cornea, crystalline, gold-dust deposition of cystine leads to visual impairment, recurrent erosions, photophobia, epiphora and blepharospasmus. Standard therapy is topical and systemic application of cysteamine which may resolve the accumulated cystine crystals...
June 18, 2018: International Ophthalmology
André Vicente, Berit Byström, Mona Lindström, Ulf Stenevi, Fátima Pedrosa Domellöf
BACKGROUND: To study structural changes in naïve and surgically treated corneas of aniridia patients with advanced aniridia-related keratopathy (ARK). METHODS AND FINDINGS: Two naïve corneal buttons from patients with advanced ARK submitted to penetrating keratoplasty for the first time, one corneal button from an ARK patient that had undergone a keratolimbal allograft (KLAL), two corneal buttons from ARK patients who had previously undergone centered or decentered transplantation and were now retransplanted and two adult healthy donor control corneas were processed for immunohistochemistry...
2018: PloS One
Qihua Le, C Michael Samson, Sophie X Deng
PURPOSE: To report a case of corneal neovascularization misdiagnosed as total limbal stem cell deficiency (LSCD). METHODS: This is a case report of a 61-year-old woman who has a history of bilateral idiopathic scleritis, keratitis, and uveitis for more than 20 years. She was diagnosed with total LSCD in her left eye based on clinical presentation alone and was confirmed as a candidate for limbal transplantation at several major tertiary eye care centers in the United States...
May 16, 2018: Cornea
Varsha M Rathi, Mukesh Taneja, Srikanth Dumpati, Preeji S Mandathara, Virender S Sangwan
PURPOSE: To report the rare coexistence of keratoconus and Stevens-Johnson syndrome (SJS) managed with scleral contact lenses (ScCLs). METHODS: This is a retrospective case series. Five patients (9 eyes) who had coexisting SJS and corneal ectasia were identified from the database during the 2-year period. Diagnosis of SJS was based on a positive history of drug reactions, signs of ocular surface disease, and the presence of keratinization of lid margins. Keratoconus was diagnosed by slit-lamp biomicroscopy...
October 2017: Cornea
Karl A Knutsson, Stanislav Matuska, Paolo Rama
PURPOSE: To describe a case of unilateral limbal stem cell deficiency (LSCD) with previously failed autologous graft, resolved by ocular surface reconstruction using cultured autologous limbal stem cells from the contralateral eye. CASE REPORT: A 35-year-old patient presented to our clinic with LSCD due to a unilateral alkali burn. The patient had received a previous limbal graft from the contralateral eye that had failed to impede corneal conjunctivalization. We decided to repeat limbal stem cell transplantation using an ex vivo cultivation procedure to reduce the risk of tissue harvesting on the healthy fellow eye...
August 30, 2017: European Journal of Ophthalmology
Paola Bargagna-Mohan, Akihiro Ishii, Ling Lei, Daniel Sheehy, Saagar Pandit, Grace Chan, Rashmi Bansal, Royce Mohan
Recent studies have shown that constitutive activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in Schwann cells (SCs) increases myelin thickness in transgenic mice. In this secondary analysis, we report that these transgenic mice develop a postnatal corneal neurofibroma with the loss of corneal transparency by age six months. We show that expansion of non-myelinating SCs, under the control of activated ERK1/2, also drive myofibroblast differentiation that derives from both SC precursors and resident corneal keratocytes...
September 2017: Journal of Neuroscience Research
Lona Jawaheer, Deepa Anijeet, Kanna Ramaesh
The diagnosis of limbal stem cell deficiency (LSCD) is often based on clinical manifestations with or without the use of tests to demonstrate the presence of goblet cells or of specific epithelial markers on the corneolimbal surface. This systematic review looks at the various diagnostic methods used in the diagnosis of LSCD in published interventional studies. The design is a systematic literature review. We did a systematic search on MEDLINE and PUBMED for articles published in English between January 1, 2003, and December 31, 2013...
July 2017: Survey of Ophthalmology
Swathi Kaliki, Faraz Ali Mohammad, Prerana Tahiliani, Virender S Sangwan
PURPOSE: To compare the surgical outcomes of ocular surface squamous neoplasia (OSSN) following wide excisional biopsy with and without primary simple limbal epithelial transplantation (p-SLET). DESIGN: Nonrandomized clinical study with historical controls. METHODS: setting: Single-institutional study. PATIENTS: Eight patients who underwent wide excisional biopsy of OSSN without p-SLET (historical controls) and 7 patients with p-SLET (cases)...
February 2017: American Journal of Ophthalmology
Peng Chen, Qingjun Zhou, Junyi Wang, Xiaowen Zhao, Haoyun Duan, Yao Wang, Ting Liu, Lixin Xie
PURPOSE: The objective of this study was to characterize the changes that occur in the cornea during Limbal Stem Cell Deficiency (LSCD) and on the corneal surface after transplantation of ex vivo cultured allogeneic limbal epithelial transplantation (CALET). METHODS: Forty-one pannus were analyzed to characterize the changes found in the cornea in LSCD. Nineteen impression cytology samples, including 14 pannus and five corneal buttons, obtained during subsequent procedures from patients who had undergone CALET were examined to assess the effect of CALET and to determine the long-term fate of donor cells...
September 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Anja Viestenz, Mona Bischoff-Jung, Achim Langenbucher, Timo Eppig, Berthold Seitz
PURPOSE: Typically, we observe an unintended hyperopic shift after phototherapeutic keratectomy (PTK). Despite a clear optical axis, elevations of the mid-peripheral cornea often lead to remarkable visual impairment in Salzmann nodular degeneration (SND). The aim of this study was to analyze the effect of mechanical pannus removal and PTK on the corneal curvature in SND. METHODS: Fifteen eyes of 10 patients with visual impairment caused by SND were treated with combined pannus removal and PTK using a masking fluid...
June 2016: Cornea
X Y Zhang, Z Q Wang, Y Zhang, X G Sun
OBJECTIVE: To summarize the clinical characteristics, diagnosis, and treatment of blepharokeratoconjunctivitis (BKC). METHODS: Retrospective analysis. One hundred and seventy-two patients were diagnosed as BKC between January 2012 and December 2014 at Beijing Tongren Hospital. The clinical characteristics, the degrees of blepharitis and BKC, and the therapeutic effect were evaluated. RESULTS: The patients were aged from 2 to 78 years (mean, 27±18 years)...
March 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Nadia Zakaria, Sorcha Ní Dhubhghaill, Michiel Taal, Zwi Berneman, Carina Koppen, Marie-José Tassignon
PURPOSE: Cultivated limbal epithelial stem cell transplantation (CLET) is a surgical approach reserved for severe stem cell deficiency and anterior segment pathology. The recipient cornea typically displays a highly vascularized pannus that must be dissected before graft placement. Extensive pannus dissection, however, can result in corneal thinning and increase the risk of ectasia and ultimately, of perforation. We aimed to examine the value of anterior segment optical coherence tomography (AS-OCT) intraoperatively during pannus resection and long-term postoperative follow-up of CLET surgery...
November 2015: Asia-Pacific Journal of Ophthalmology
K Diongue, A S Sow, M Nguer, M C Seck, M Ndiaye, A S Badiane, J M Ndiaye, N W Ndoye, M A Diallo, A Diop, Y D Ndiaye, B Dieye, A Déme, I M Ndiaye, O Ndir, D Ndiaye
In developing countries where systemic antifungal are often unavailable, treatment of filamentous fungi infection as Fusarium is sometimes very difficult to treat. We report the case of a keratomycosis due to Fusarium oxysporum treated by povidone iodine eye drops and oral fluconazole. The diagnosis of abscess in the cornea was retained after ophthalmological examination for a 28-year-old man with no previous ophthalmological disease, addressed to the Ophthalmological clinic at the University Hospital Le Dantec in Dakar for a left painful red eye with decreased visual acuity lasting for 15 days...
December 2015: Journal de Mycologie Médicale
Shilpa Das, Sayan Basu, Virender Sangwan
One day after molten aluminium had fallen into his right eye, a young man presented to our clinic with a vision of counting fingers at 1 m, conjunctival and corneal epithelial defects, and limbal involvement. He was diagnosed with grade 4 thermal burn and managed medically. Subsequently, the inflammation resolved, however, he developed pannus with conjunctivalisation and scarring of cornea suggestive of partial unilateral limbal stem cell deficiency. He was treated surgically with autologous simple limbal epithelial transplantation (SLET)...
July 6, 2015: BMJ Case Reports
Chunxiao Wang, Xueying Xia, Feipeng Wang, Shaobi Ye, Shiyou Zhou
PURPOSE: To evaluate the clinical use of optical coherence tomography (OCT) in optimizing surgical treatment strategies for conjunctivalized corneas secondary to ocular burns. METHODS: This noncomparative observational study included 25 patients with stable ocular burns and conjunctivalized corneas. OCT was performed on each eye. The thickness of corneal opacity or pseudopterygium and the underlying healthy stroma were measured. Individual surgical strategies were performed based on clinical examination and OCT images...
October 2015: Cornea
Emilio Pedrotti, Mattia Passilongo, Adriano Fasolo, Mario Nubile, Graziella Parisi, Rodolfo Mastropasqua, Sara Ficial, Marina Bertolin, Enzo Di Iorio, Diego Ponzin, Giorgio Marchini
PURPOSE: To correlate clinical, impression cytologic, and in vivo confocal microscopy findings on the corneal surface after cultured limbal stem cell transplantation. DESIGN: Prospective, interventional, noncomparative, masked case series. PARTICIPANTS: Thirteen patients with limbal stem cell deficiency after unilateral (9 eyes) or bilateral (2 eyes) chemical burn, liquid nitrogen injury (1 eye), or herpes simplex virus infection (1 eye). METHODS: Limbal cells were harvested from healthy or less affected eyes, cultured on 3T3 cells and fibrin glue, and transplanted to the patient's injured eye...
August 2015: Ophthalmology
Elias Chelala, Hala El Rami, Ali Dirani, Henry Fakhoury, Ali Fadlallah
BACKGROUND: Superior limbic keratoconjunctivitis (SLK) is characterized as an inflammation of the superior bulbar conjunctiva with predominant involvement of the superior limbus and adjacent epithelial keratitis. METHODS: A 51-year-old woman, with a history of medically controlled Graves' disease was seen with an extensive SLK involving 5 mm of the superior cornea. RESULTS: Total remission was observed with topical steroids (DXM). Recurrence was observed 1 week after steroid discontinuation, and steroidal treatment was reintroduced with tapering over 1 month...
2015: Clinical Ophthalmology
Alok Sati, Sayan Basu, Virender S Sangwan, Geeta K Vemuganti
BACKGROUND/AIMS: To report the influence of histological features of corneal surface pannus following ocular surface burn on the outcome of cultivated limbal epithelial transplantation (CLET). METHODS: On retrospectively reviewing the medical records of the patients who underwent autologous CLET from April 2002 to June 2012 at L V Prasad Eye Institute, Hyderabad, India, we could trace the histological reports in only 90 records. These 90 records, besides clinical parameters, were reviewed for the influence of various histological features on the final outcome of CLET...
April 2015: British Journal of Ophthalmology
Philip B Meadow, Jacqueline Nguyen, Keerthana Kesavarapu
Purpose. To report a case of a patient with rheumatoid arthritis (RA) treated with tofacitinib citrate. Methods. Observational case report. Results. A 59-year-old patient, with a history of rheumatoid arthritis, on methotrexate 10 mg PO qwk and IV abatacept 750 mg/month, presented with photosensitivity, foreign body sensation, pain, redness, and blurry vision of her right eye (RE). Visual acuity of the RE was 20/200 and 20/20 of the left eye (LE). The slit lamp examination of the RE revealed dryness, 2+ injection of the conjunctiva, and pericentral ulceration of the cornea with 20-30% stromal thinning, pannus, and diffuse punctate epithelial erosions...
2014: Case Reports in Rheumatology
Joginder Pal Chugh, Prachi Jain, Rajeev Sen
To compare the role of fresh and dry preserved amniotic membrane transplantation (AMT) in partial limbal stem cell deficiency (LSCD). 30 Patients of partial LSCD involving <180° of cornea of different age group were divided into 2 groups; group A and B. Clinical diagnosis was made on the basis of presence of conjunctival pannus over cornea and loss of limbal palisades of Vogt. After taking impression cytology from the corneal surface, group A patients underwent conjunctival pannus resection followed by fresh AMT while group B patients underwent dry preserved AMT after resection of pannus...
June 2015: International Ophthalmology
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