Cheng Ma, Yanping Luo, Congyi Zhang, Cheng Cheng, Ning Hua, Xiaocao Liu, Jianan Wu, Luying Qin, Peilin Yu, Jianhong Luo, Fan Yang, Lin-Hua Jiang, Guojie Zhang, Wei Yang
Ion channel activation upon ligand gating triggers a myriad of biological events and, therefore, evolution of ligand gating mechanism is of fundamental importance. TRPM2, a typical ancient ion channel, is activated by adenosine diphosphate ribose (ADPR) and calcium and its activation has evolved from a simple mode in invertebrates to a more complex one in vertebrates, but the evolutionary process is still unknown. Molecular evolutionary analysis of TRPM2s from more than 280 different animal species has revealed that, the C-terminal NUDT9-H domain has evolved from an enzyme to a ligand binding site for activation, while the N-terminal MHR domain maintains a conserved ligand binding site...
April 26, 2024: Science Bulletin