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https://www.readbyqxmd.com/read/28945041/-dynamic-serum-metabolomics-study-of-liver-injury-in-rats-caused-by-polygonum-multifulorum
#1
Zhi-Jie Ma, Qi Li, Kui-Jun Zhao, Jia-Bo Wang, Xiao-He Xiao
Liquid chromatography-mass spectrometry method was used for determination of metabolic fingerprint spectrum in rat serum, and the method of multivariate statistical analysis was used to compare the metabolism spectrum difference and screen significantly related biomarkers. The dynamic change trend was investigated at the same time. The dynamic metabonomics changes of liver injury in rats caused by Polygonum multifulorum(PM) were investigated; significantly related biomarkers were found and their dynamic change trend was investigated to provide basis for internal mechanism and early clinical diagnosis...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945033/-preparation-and-evaluation-of-gastric-adhesive-floating-pellets-for-bolo-leaf-phenols
#2
Ya-Li He, Ying Li, Dan-Dan Yang, Chun-Yan Zhu
Gastric adhesive-floating pellets for Bolo leaf phenols (BLP) were prepared by extrusion-spheronization method, with chitosan as skeleton bioadhesive material, and stearyl alcohol as help-bleaching agent to evaluate its in vitro adhesivity, floatability and in vivo retention situation, and investigate its in vitro release characteristics. The in vitro adhesivity and floatability were evaluated respectively by in vitro tissue retention method and visual observation method. The retention of pellets in rats was investigated by in vivo tissue retention method and in vivo imaging of small animals...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945028/-effects-of-methyl-jasmonate-on-accumulation-of-furanocoumarins-in-changium-smyrnioides-and-its-suspension-cells
#3
Jing Cai, Yun Ma, Jian-Wei Chen, Xiang Li, Ping Zhou
Changium smyrnioides is an endangered and endemic medicinal herb in China which contains rich furanocoumarins. Bergaptol, bergapten and xanthotoxin are natural furanocoumarins in Ch. smyrnioides, among which bergaptol is mainly contained in in vitro cultures while the latter ones distribute in all organs and cultures of the plant. In this study, methyl jasmonate was used to elicit furanocoumarins in both cultivated plant and suspension cells. The accumulations of biomass and 3 furanocoumarins as well as the activity of cell, phenylalanine ammonia-lyase and antioxidase were detected...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945011/prediction-of-drug-drug-interaction-between-tacrolimus-and-principal-ingredients-of-wuzhi-capsule-in-chinese-healthy-volunteers-using-physiologically-based-pharmacokinetic-modelling
#4
Hongyan Zhang, Fengjiao Bu, Lei Li, Zheng Jiao, Guo Ma, Weimin Cai, Xiaomei Zhuang, Hai-Shu Lin, Jae-Gook Shin, Xiaoqiang Xiang
Schisantherin A and schisandrin A, the most abundant active ingredients of Wuzhi capsule, are known to inhibit tacrolimus metabolism by inhibiting CYP3A4/5. We aimed to predict the contribution of schisantherin A and schisandrin A to drug-drug interaction (DDI) between Wuzhi capsule and tacrolimus using physiologically-based pharmacokinetic (PBPK) modelling. Firstly, the inhibition mechanism of schisantherin A and schisandrin A on CYP3A4/5 were investigated. Thereafter, PBPK models of schisantherin A, schisandrin A and tacrolimus were established...
September 25, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28944997/desire-for-parenthood-and-reproductive-health-knowledge-in-adolescents-and-young-adults-with-sickle-cell-disease-and-their-caregivers
#5
Leena Nahata, Nicole M Caltabellotta, Kyle Ball, Sarah H O'Brien, Susan E Creary
BACKGROUND/OBJECTIVE: Sickle cell disease (SCD) and hydroxyurea have implications for fertility and reproductive health. The goal of this study was to examine desire for parenthood and reproductive health knowledge among a cohort of adolescent and young adult (AYA) with SCD receiving hydroxyurea and their caregivers at a large pediatric academic center. METHODS: Patients with SCD were approached from September 2016 to July 2017 if they were: (1) 12-20 years old, (2) prescribed hydroxyurea for at least 6 months, (3) proficient in English, and (4) accompanied by a caregiver who was proficient in English and willing to participate...
September 25, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28944985/ultrasound-characteristics-of-endometrial-cancer-as-defined-by-the-international-endometrial-tumor-analysis-ieta-consensus-nomenclature-a-prospective-multicenter-study
#6
Elisabeth Epstein, Daniela Fischerova, Lil Valentin, Antonia Carla Testa, Dorella Franchi, Povilas Sladkevicius, Frühauf Filip, Pelle G Lindqvist, Floriana Mascilini, Robert Fruscio, Lucia Anna Haak, Gina Opolskiene, Maria Angela Pascual, Juan Luis Alcazar, Valentina Chiappa, Stefano Guerriero, Joseph Carlson, Caroline Van Holsbeke, Francesco Paolo Giuseppe Leone, Bart De Moor, Tom Bourne, Ben van Calster, Arnaud Installe, Dirk Timmerman, Jan Y Verbakel, Thierry Van den Bosch
OBJECTIVES: To describe the sonographic features of endometrial cancer in relation to stage, grade, and histological type using the International Endometrial Tumor Analysis (IETA) terminology. METHODS: Prospective multicenter study on 1714 women with endometrial cancer undergoing a standardized transvaginal grayscale and Doppler ultrasound examination by an experienced ultrasound examiner using a high-end ultrasound system. Clinical and sonographic data were entered into a web-based protocol...
September 25, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28944982/evaluation-of-inos-inhibition-on-kidney-function-and-structure-in-high-fat-diet-induced-kidney-disease
#7
Blanche Martin, Nathalie Caron, Inès Jadot, Vanessa Colombaro, Gabrielle Federici, Clara Depommier, Anne-Émilie Declèves
BACKGROUND: Central obesity is related to caloric excess promoting deleterious cellular responses in targeted organs. Nitric oxide (NO) has been determined as a key player in the pathogenesis of metabolic diseases. Here, we investigated the implication of inducible NO synthase (iNOS) in the development of obesity-induced kidney disease. MATERIALS AND METHODS: C57Bl/6 male mice were randomized to a low-fat diet (LFD) or a high-fat diet (HFD) and treated with L-NIL, a specific iNOS inhibitor for 16 weeks...
September 25, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28944965/comparison-of-psoriasis-and-atopic-dermatitis-guidelines-an-argument-for-aggressive-atopic-dermatitis-management
#8
Mary E Lohman, Peter A Lio
The development of effective systemic treatments has revolutionized the treatment of inflammatory skin diseases. The availability of safe new treatments and the understanding of psoriasis as a systemic disease with comorbidities and effects on quality of life have driven the current aggressive treatment paradigm of psoriasis. Historically the morbidity of atopic dermatitis (AD) has been dismissed, given the perception of AD as "just" a rash. Differences in the guidelines for psoriasis and AD management may suggest variations in the current conceptualization of disease severity and effects on quality of life...
September 25, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28944961/two-case-studies-on-how-study-designs-can-be-made-more-informative-using-modeling-and-simulation-approaches
#9
Philip J Lowe, Martin Fink, Mark N Milton
Drug development should extract maximum information from experiments with minimized exposure of patients or experimental animals to invasive procedures and potentially harmful effects with minimized investment of time and money. Herein, two aspects of study design are explored illustrating how information can be extracted more efficiently by investigating a range of exposures within each individual by either following responses as drug concentrations decline or by within-individual dose escalation, rather than relying on steady-state cross-sectional analyses...
September 25, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28944948/use-and-modifications-of-cervical-and-upper-thoracic-laminar-screws-in-posterior-stabilization
#10
Burak Eren, Azmi Tufan, Feyza Karagöz Güzey, İlker Güleç, Abdurrahim Taş, Özgür Yusuf Aktaş, Mustafa Safi Vatansever, Ebru Doruk, Murat Yücel, Mustafa Örnek
AIM: Laminar screw technique is used to stabilize C2 and other levels when other techniques cannot be performed. MATERIAL AND METHODS: The patients underwent laminar screws at cervical and upper thoracic levels in our clinic during 5 yearswere evaluated retrospectively. RESULTS: In 25 patients, 6 to 82 years old,total 54 laminar screws were used. Most frequent diagnoses were cervical spinal stenosis and craniovertebraljunction anomalies.There were handicaps to perform other type of screwsin 19 out of 25 screws during first 4 years, and 9 out of 29 in the last year (p=0...
July 16, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28944937/individual-development-and-potential-determinants-of-excess-weight-in-children-and-adolescents-a-longitudinal-study
#11
Alexandra Papandreou, Matthias Bopp, Julia Braun, Kaspar Staub, David Faeh
OBJECTIVES: Excess body weight is a major public health concern already at a young age. The aim of this study was to track weight status among pupils aged 6-14 years in the City of Zurich, to examine the association between sociodemographic and environmental factors and excess weight at school entry and excess weight gain thereafter. DESIGN: Longitudinal study. SETTING: Data were from the medical examinations routinely performed at public schools in Zurich, the largest city in Switzerland...
September 25, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28944906/peptidome-analysis-of-amniotic-fluid-from-pregnancies-with-preeclampsia
#12
Yating Qian, Lei Zhang, Can Rui, Hongjuan Ding, Pengyuan Mao, Hongjie Ruan, Ruizhe Jia
Preeclampsia (PE), a life‑threatening, complicated pregnancy‑associated disease, has recently become a research focus in obstetrics. However, the peptidome of the amniotic fluid in PE patients has rarely been investigated. The present study used peptidomic profiling to perform a comparative analysis of human amniotic fluid between normal and PE pregnancies. Centrifugal ultrafiltration and liquid chromatography‑tandem mass spectrometry (LC‑MS/MS) was combined with isotopomeric dimethyl labels to gain a deeper understanding of the role of proteins and the peptidome in the onset of PE...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944798/transcriptomic-analysis-of-bama-pig-s-liver-in-various-nutritional-states-reveals-a-metabolic-difference-of-fatty-acids
#13
Yixing Li, Yi Chu, Lin Yu, Huifang Kang, Lei Zhou
Both fasting and treatment with a high-fat diet (HFD) can dramatically change fat metabolism in the liver and, thus, are commonly used methods to investigate hepatic fat metabolism and related diseases. Here, the gene expression profiles of pig liver under both conditions were investigated and changes in hepatic triacylglycerol (TG) levels under different diet conditions were determined. In this study, both fasting and HFD conditions significantly increased hepatic TG levels and serum levels of cholesterol, TG, high-density lipoprotein, low-density lipoprotein, and apolipoprotein B...
September 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28944746/using-two-sex-life-tables-to-determine-fitness-parameters-of-four-bactrocera-species-diptera-tephritidae-reared-on-a-semi-artificial-diet
#14
W Jaleel, J Yin, D Wang, Y He, L Lu, H Shi
Fruit flies in the genus Bactrocera are global, economically important pests of agricultural food crops. However, basic life history information about these pests, which is vital for designing more effective control methods, is currently lacking. Artificial diets can be used as a suitable replacement for natural host plants for rearing fruit flies under laboratory conditions, and this study reports on the two-sex life-table parameters of four Bactrocera species (Bactrocera correcta, Bactrocera dorsalis, Bactrocera cucurbitae, and Bactrocera tau) reared on a semi-artificial diet comprising corn flour, banana, sodium benzoate, yeast, sucrose, winding paper, hydrochloric acid and water...
September 25, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28944734/outcomes-based-contracting-experience-research-findings-from-u-s-and-european-stakeholders
#15
Tara Nazareth, John J Ko, Rahul Sasane, Christian Frois, Stephen Carpenter, Sebastian Demean, Ashok Vegesna, Eric Wu, Robert P Navarro
BACKGROUND: Outcomes-based contracts (OBCs), a type of risk-sharing arrangement (RSA), have emerged as a promising avenue for payers to engage with pharmaceutical manufacturers to share risk and improve patient access to medicines via evaluation of real-world outcomes. OBJECTIVE: To assess the level of recent OBC activity and stakeholder perceptions of these arrangements, as well as the outlook for future OBC activity from a payer and manufacturer perspective in the United States and EU-5 (France, Germany, Italy, Spain, and the United Kingdom)...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944733/performance-based-risk-sharing-arrangements-for-pharmaceutical-products-in-the-united-states-a-systematic-review
#16
Justin S Yu, Lauren Chin, Jennifer Oh, Jorge Farias
BACKGROUND: Value for money is a growing necessity in today's U.S. health care system in which drug spending is expected to increase by an average rate of 6.7% yearly through 2025. In response to uncertainty about real-world clinical and economic outcomes for many drugs, health insurers and pharmacy benefit managers (PBMs) have implemented various contracts and arrangements with drug manufacturers that can collectively be described as performance-based risk-sharing arrangements (PBRSAs)...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944732/patient-centered-drug-approval-the-role-of-patient-advocacy-in-the-drug-approval-process
#17
T Joseph Mattingly, Linda Simoni-Wastila
Recent approval of eteplirsen for Duchenne muscular dystrophy (DMD), a rare disease with few treatment alternatives, has reignited the debate over the U.S. drug approval process. The evolution of legal and regulatory restrictions to the marketing and sale of pharmaceuticals has spanned more than a century, and throughout this history, patient advocacy has played a significant role. Scientific evidence from clinical trials serves as the foundation for drug approval, but the patient voice has become increasingly influential...
October 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28944718/obesity-is-associated-with-altered-mid-insula-functional-connectivity-to-limbic-regions-underlying-appetitive-responses-to-foods
#18
Jason A Avery, Joshua N Powell, Florence J Breslin, Rebecca J Lepping, Laura E Martin, Trisha M Patrician, Joseph E Donnelly, Cary R Savage, W Kyle Simmons
Obesity is fundamentally a disorder of energy balance. In obese individuals, more energy is consumed than is expended, leading to excessive weight gain through the accumulation of adipose tissue. Complications arising from obesity, including cardiovascular disease, elevated peripheral inflammation, and the development of Type II diabetes, make obesity one of the leading preventable causes of morbidity and mortality. Thus, it is of paramount importance to both individual and public health that we understand the neural circuitry underlying the behavioral regulation of energy balance...
September 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28944709/the-cardiometabolic-effect-of-current-management-of-polycystic-ovary-syndrome-strategies-of-prevention-and-treatment
#19
Dinka Pavicic Baldani, Lana Skrgatic, Roya Ougouag, Miro Kasum
Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder amongst women of reproductive age, which is characterized by reproductive and cardiometabolic disturbances with long-term health repercussions. Insulin resistance (IR), impaired glucose tolerance, type 2 diabetes mellitus (DM2), obesity and dyslipidemia occur more in women with PCOS than in age-comparable women without PCOS. Long term data regarding risks or benefits of medical intervention for metabolic dysfunction of PCOS are lacking. Therapies, such as oral contraceptives (OCPs) and anti-androgenic medications used to manage the reproductive manifestations of PCOS, may themselves be the cause of cardiometabolic perturbations...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28944696/suicidal-bupropion-ingestions-in-adolescents-increased-morbidity-compared-with-other-antidepressants
#20
David C Sheridan, Amber Lin, B Zane Horowitz
OBJECTIVE: Bupropion is often categorized as a newer generation antidepressant and assessed with serotonin reuptake inhibitors as a lower risk than older tricyclic antidepressants (TCAs). The objective of this study was to compare outcomes in adolescent suicide from ingestions between bupropion and TCA medications. STUDY DESIGN: An analysis of the National Poison Data System for exposures coded "suspected suicide" in adolescents (age: 13-19) was undertaken for the years 2013-2016 and included TCAs or bupropion...
September 25, 2017: Clinical Toxicology
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