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Thujone

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https://www.readbyqxmd.com/read/28395994/thujone-inhibits-the-function-of-%C3%AE-7-nicotinic-acetylcholine-receptors-and-impairs-nicotine-induced-memory-enhancement-in-one-trial-passive-avoidance-paradigm
#1
Ahmed Sultan, Keun-Hang Susan Yang, Dmitro Isaev, Eslam El Nebrisi, Nurulain Syed, Nadia Khan, Christopher F Howarth, Bassem Sadek, Murat Oz
Effects of thujone, a major ingredient of absinthe, wormwood oil and some herbal medicines, were tested on the function of α7 subunit of the human nicotinic acetylcholine (α7 nACh) receptor expressed in Xenopus oocytes using the two-electrode voltage-clamp technique. Thujone reversibly inhibited ACh (100μM)-induced currents with an IC50 value of 24.7μM. The effect of thujone was not dependent on the membrane potential and did not involve Ca(2+)-dependent Cl(-) channels expressed endogenously in oocytes...
April 7, 2017: Toxicology
https://www.readbyqxmd.com/read/28381767/volatile-components-of-the-essential-oil-of-artemisia-montana-and-their-sedative-effects
#2
Kento Kunihiro, Takao Myoda, Noriaki Tajima, Kotaro Gotoh, Tai Kaneshima, Takao Someya, Kazuki Toeda, Takane Fujimori, Makoto Nishizawa
The sedative effects of volatile components in the essential oil of Artemisia montana ("Yomogi") were investigated and measured using gas chromatography-mass spectrometry (GC-MS). Major components identified included 1,8-cineol, camphor, borneol, α-piperitone, and caryophyllene oxide. Among them, 1,8-cineol exhibited the highest flavor dilution (FD) value in an aroma extract dilution analysis (AEDA), followed by borneol, o-cymene, β-thujone, and bornyl acetate. The sedative effects of yomogi oil aroma were evaluated by sensory testing, analysis of salivary α-amylase activity, and measurement of relative fluctuation of oxygenated hemoglobin concentration in the brain using near-infrared spectroscopy (NIRS)...
April 4, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28378196/eco-friendly-control-of-the-poultry-red-mite-dermanyssus-gallinae-dermanyssidae-using-the-%C3%AE-thujone-rich-essential-oil-of-artemisia-sieberi-asteraceae-toxic-and-repellent-potential
#3
Mohaddeseh Abouhosseini Tabari, Mohammad Reza Youssefi, Giovanni Benelli
The poultry red mite, Dermanyssus gallinae, represents a key threat for the poultry industry worldwide. The control of D. gallinae is mainly achieved by continuous applications of acaricides. However, the fast-growing development of resistance, and the strict laws concerning chemicals admitted for treatments on food animals, highlighted the importance of alternative control tools. Here, we explored the potential of Artemisia sieberi essential oil against D. gallinae. In this study, the A. sieberi essential oil was analyzed using GC and GC-MS...
April 5, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28346993/artemisia-sieberi-besser-essential-oil-and-treatment-of-fungal-infections
#4
REVIEW
Mohaddese Mahboubi
A. sieberi essential oil has been used for treatment of hardly curable infectious ulcers in Middle East Medicine and has been famous due to its wormicide effects. In this review, we evaluated the potency of A. sieberi essential oil in treatment of fungal infections. We searched in PubMed Central, Science direct, Wiley, Springer, SID, and accessible books, reports, thesis. There is a lot of mixed information on chemical compositions of A. sieberi essential oil, but most articles reported α, β-thujones as the main components of essential oils...
March 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28314999/genetic-diversity-and-metabolic-profile-of-salvia-officinalis-populations-implications-for-advanced-breeding-strategies
#5
Eirini Sarrou, Ioannis Ganopoulos, Aliki Xanthopoulou, Domenico Masuero, Stefan Martens, Panagiotis Madesis, Athanasios Mavromatis, Paschalina Chatzopoulou
As a result of this work, we were able to characterize seven indigenous to Greece Salvia officinalis populations using genetic and metabolomic tools. These tools can be used to select the most promising genotypes, capable to design future breeding programs for high valuable varieties. An initial investigation was carried out to compare the genetic and metabolic diversity in S. officinalis grown in Greece and to discern the relationship between the two sets of data. Analysis of inter-simple sequence repeats (ISSR) revealed significant genetic differences among seven sage populations, which were grouped into three main clusters according to an UPGMA ISSR data-based dendrogram and Principle Coordinate Analysis...
March 17, 2017: Planta
https://www.readbyqxmd.com/read/28276694/artemisia-umbelliformis-lam-and-g%C3%A3-n%C3%A3-pi-liqueur-volatile-profile-as-diagnostic-marker-for-geographic-origin-and-to-predict-liqueur-safety
#6
Lorenzo Boggia, Giuseppe Pignata, Barbara Sgorbini, Maria Laura Colombo, Arianna Marengo, Manuela Casale, Silvana Nicola, Carlo Bicchi, Patrizia Rubiolo
Artemisia umbelliformis, commonly known as "white génépi", is characterized by a volatile fraction rich in α- and β-thujones, two monoterpenoids; under European Union (EU) regulations these are limited to 35 mg/L in Artemisia-based beverages because of their recognized activity on the human central nervous system. This study reports the results of an investigation to define the geographical origin and thujone content of individual plants of A. umbelliformis from different geographical sites, cultivated experimentally at a single site, and to predict the thujone content in the resulting liqueurs through their volatile fraction...
March 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27976467/rapid-species-level-identification-of-salvias-by-chemometric-processing-of-ambient-ionisation-mass-spectrometry-derived-chemical-profiles
#7
Justine E Giffen, Ashton D Lesiak, A John Dane, Robert B Cody, Rabi A Musah
INTRODUCTION: The Salvia genus contains numerous economically important plants that have horticultural, culinary and nutraceutical uses. They are often similar in appearance, making species determination difficult. Species identification of dried Salvia products is also challenging since distinguishing plant morphological features are no longer present. OBJECTIVE: The development of a simple high-throughput method of analysis of fresh and dried Salvia leaves that would permit rapid species-level identification and detection of diagnostic biomarkers...
January 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27913788/safety-assessment-of-achillea-millefolium-as-used-in-cosmetics
#8
Lillian C Becker, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
Cosmetic ingredients derived from Achillea millefolium function in cosmetics as skin-conditioning agents-miscellaneous, skin-conditioning agents-humectants, and fragrance ingredients. The Cosmetic Ingredient Review Expert Panel (Panel) reviewed relevant animal and human data to determine their safety in cosmetics and raised concerns about cosmetics containing linalool, thujone, quercetin, hydroquinone, or α-peroxyachifolid. Because final product formulations may contain multiple botanicals, each containing similar constituents of concern, formulators are advised to be aware of these components and to avoid reaching levels that may be hazardous to consumers...
November 2016: International Journal of Toxicology
https://www.readbyqxmd.com/read/27879146/chemical-composition-and-antifungal-activity-of-essential-oils-from-medicinal-plants-of-kazakhstan
#9
Diego A Sampietro, Analía de Los A Gomez, Cristina M Jimenez, Emilio F Lizarraga, Zharkyn A Ibatayev, Yerlan M Suleimen, Cesar A Catalán
The composition of essential oils from leaves of Kazakhstan medicinal plants was analysed by GC-MS. The major compounds identified were 1,8-cineole (34.2%), myrcene (19.1%) and α-pinene (9.4%) in Ajania fruticulosa; 1,8-cineole (21.0%), β-thujone (11.0%), camphor (8.5%), borneol (7.3%) and α-thujone (6.5%), in Achillea nobilis; camphor (47.3%), 1,8-cineole (23.9%), camphene (9.8%) and β-thujone (6.0%) in Artemisia terrae-albae; 1,8-cineole(55.8%) and β-pinene (6.2%) in Hyssopus ambiguus; α-thuyene(46...
November 23, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27770682/activity-of-essential-oil-based-microemulsions-against-staphylococcus-aureus-biofilms-developed-on-stainless-steel-surface-in-different-culture-media-and-growth-conditions
#10
Campana Raffaella, Luca Casettari, Laura Fagioli, Marco Cespi, Giulia Bonacucina, Wally Baffone
Food safety is a fundamental concern for both consumers and the food industry, especially as the numbers of reported cases of food-associated infections continue to increase. Industrial surfaces can provide a suitable substrate for the development and persistence of bacterial organized in biofilms that represent a potential source of food contamination. The negative consumer perception of chemical disinfectants has shifted the attention to natural substances, such as plant extracts. The aim of this study was to investigate the possibility of using the essential oils (EOs) in the fight against S...
January 16, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27770606/simultaneous-formulation-of-terbinafine-and-salvia-monoterpenes-into-chitosan-hydrogel-with-testing-biological-activity-of-corresponding-dialysates-against-c-albicans-yeast
#11
Alexandra Kodadová, Zuzana Vitková, Jarmila Oremusová, Petra Herdová, Anton Ťažký, Peter Mikuš
This work was aimed at a progressive formulation of drugs into chitosan hydrogels. It was taken into consideration that a therapeutic effect of the drugs could be enhanced by a combination of natural compounds with chemical (synthetic) drugs. In this work, sage essential oil (SEO) bicyclic monoterpenes with antiflogistic, antiseptic, and antimycotic properties were combined with terbinafine (TB) having a strong antimycotic activity. Detail optimization of the hydrogel-drugs composition (SEO monoterpenes, TB, chitosan, and polysorbate 80 concentrations), based on permeation experiment and UV absorption/GC-MS analysis of permeated species (eucalyptol, camphor, borneol, thujone, TB) in dialysates, was made...
January 1, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/27709180/a-six-step-total-synthesis-of-%C3%AE-thujone-and-d6-%C3%AE-thujone-enabling-facile-access-to-isotopically-labelled-metabolites
#12
Irene Thamm, Johannes Richers, Michael Rychlik, Konrad Tiefenbacher
The short synthesis of α-thujone relies on the functionalization of the readily available dimethylfulvene. Furthermore, the three main metabolites of the natural product were also synthesized. Since d6-acetone can be used as a starting material, the route developed allows for the facile incorporation of isotopic labels which are required for detecting and quantifying trace amounts via GC/MS analysis.
September 22, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27525992/chemotypic-variation-in-volatiles-and-herbivory-for-sagebrush
#13
Richard Karban, Patrick Grof-Tisza, James D Blande
Plants that are damaged by herbivores emit complex blends of volatile compounds that often cause neighboring branches to induce resistance. Experimentally clipped sagebrush foliage emits volatiles that neighboring individuals recognize and respond to. These volatiles vary among individuals within a population. Two distinct types are most common with either thujone or camphor as the predominate compound, along with other less common types. Individuals respond more effectively to cues from the same type, suggesting that some of the informative message is contained in the compounds that differentiate the types...
August 2016: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/27451252/a-new-chemical-tool-for-absinthe-producers-quantification-of-%C3%AE-%C3%AE-thujone-and-the-bitter-components-in-artemisia-absinthium
#14
Benoit Bach, Marilyn Cleroux, Mayra Saillen, Patrik Schönenberger, Stephane Burgos, Julien Ducruet, Armelle Vallat
The concentrations of α/β-thujone and the bitter components of Artemisia absinthium were quantified from alcoholic wormwood extracts during four phenological stages of their harvest period. A solid-phase micro-extraction method coupled to gas chromatography-mass spectrometry was used to determine the concentration of the two isomeric forms of thujone. In parallel, the combination of ultra-high pressure liquid chromatography and high resolution mass spectrometry allowed to quantify the compounds absinthin, artemisetin and dihydro-epi-deoxyarteannuin B...
December 15, 2016: Food Chemistry
https://www.readbyqxmd.com/read/27447740/artemisia%C3%A2-arborescens-essential-oil-composition-enantiomeric-distribution-and-antimicrobial-activity-from-different-wild-populations-from-the-mediterranean-area
#15
Mohammed El-Amin Said, Marcello Militello, Sergio Saia, Luca Settanni, Aurora Aleo, Caterina Mammina, Isabelle Bombarda, Pierre Vanloot, Christian Roussel, Nathalie Dupuy
Aerial parts of Artemisia arborescens were collected from different sites of the Mediterranean area (southwestern Algeria and southern Italy) and the chemical composition of their essential oil (EO) extracted by hydrodistillation was studied by both gas chromatography (GC) equipped with an enantioselective capillary column and GC/mass spectrometry (GC/MS). The EOs obtained were tested against several Listeria monocytogenes strains. Using GC and GC/MS, 41 compounds were identified, accounting for 96.0 - 98...
August 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27286334/vapour-and-liquid-phase-artemisia-annua-essential-oil-activities-against-several-clinical-strains-of-candida
#16
Francesca Santomauro, Rosa Donato, Cristiana Sacco, Gabriella Pini, Guido Flamini, Anna Rita Bilia
Candida spp. are often the cause of infection in immune-compromised individuals. They are characterized by a strong resistance to antimicrobial drugs and disinfectants. The activity of Artemisia annua essential oil against Candida spp. was determined by vapour contact and microdilution assay. The oil was characterized by the presence of oxygenated monoterpenes (more than 75 % of the constituents), mainly represented by the irregular monoterpene artemisia ketone (ca. 22 %), and the widespread monoterpenes 1,8 cineole (ca...
July 2016: Planta Medica
https://www.readbyqxmd.com/read/27181395/detection-of-the-previously-unobserved-stereoisomers-of-thujone-in-the-essential-oil-and-consumable-products-of-sage-salvia-officinalis-l-using-headspace-solid-phase-microextraction-gas-chromatography-mass-spectrometry
#17
Jack D Williams, Jessica A Yazarians, Chelcie C Almeyda, Kristin A Anderson, Gregory R Boyce
The discovery of the (+)-α-thujone and (-)-β-thujone stereoisomers in the essential oil of sage (Salvia officinalis L.) and dietary supplements is documented for the first time. The detection was accomplished using a chiral resolution protocol of racemic α-/β-thujone on headspace solid-phase microextraction-gas chromatography-mass spectrometry. Because the previously unreported stereoisomers, (+)-α-thujone and (-)-β-thujone, are not commercially available, a three-step synthesis of racemic thujone from commercially available starting materials was developed...
June 1, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27174212/effects-of-bioactive-monoterpenic-ketones-on-membrane-organization-a-langmuir-film-study
#18
María Elisa Mariani, Mariela E Sánchez-Borzone, Daniel A García
The cyclic ketones, thujone and dihydrocarvone, are lipophilic components of essential oils extracted from different plants, which have proven insecticidal activity. The GABAA receptor is activated by the neurotransmitter GABA and is the action site of widely used neurotoxic pesticides. Many compounds that regulate GABAA receptor function interact with membrane lipids, causing changes in their physical properties and consequently, in the membrane dynamic characteristics that modulate receptor macromolecules...
2016: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/26900077/pro-apoptotic-and-anti-angiogenic-properties-of-the-%C3%AE-%C3%AE-thujone-fraction-from-thuja-occidentalis-on-glioblastoma-cells
#19
Angelo Torres, Yosselyn Vargas, Daniel Uribe, Cristian Carrasco, Cristian Torres, René Rocha, Carlos Oyarzún, Rody San Martín, Claudia Quezada
The most aggressive type of brain tumor is glioblastoma multiforme, which to date remains incurable. Thuja occidentalis is used in homeopathy for the treatment of cancer, however, its mechanism of action remains unknown. We set out to study the effects of thujone fractions of Thuja on glioblastoma using in vitro and in vivo models. We found that the α/ β-thujone fraction decrease the cell viability and exhibit a potent anti-proliferative, pro-apoptotic and anti-angiogenic effects in vitro. In vivo assays showed that α /β-thujone promotes the regression of neoplasia and inhibits the angiogenic markers VEGF, Ang-4 and CD31 into the tumor...
May 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/26773227/the-determination-of-%C3%AE-and-%C3%AE-thujone-in-human-serum-simple-analysis-of-absinthe-congener-substance
#20
Michal P Dybowski, Andrzej L Dawidowicz
Absinthe is a strong spirit beverage, mostly green in color, containing besides ethyl alcohol (main component), alcoholic macerate of wormwood and other plants such as star anise and fennel seed. Due to the potential risks associated with the presence of α- and β-thujone many countries have implemented strict rules limiting the content of these congeners in alcohol products. The presented paper describes a simple and sensitive method for the determination of α- and β-thujone in human serum using Solid Phase Extraction as a sample preparation method combined with GC/MS analysis...
February 2016: Forensic Science International
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