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absinthe poisoning

John R Hughes
The tragic life of Vincent van Gogh is summarized, emphasizing his early departure from formal education, failure as a successful salesman in the art world, attempt at religious studies, difficulty with female and family relationships, return to the art world, and tendencies toward extremes of poor nutrition or near self-starvation and excessive drinking and smoking. In Paris he joined the Impressionists, but drank very heavily both absinthe and cognac. Southward he went to Arles and was joined by Paul Gauguin, with whom he had major personality problems, causing van Gogh to cut off part of his left ear...
June 2005: Epilepsy & Behavior: E&B
Maik Behrens, Anne Brockhoff, Christina Kuhn, Bernd Bufe, Marcel Winnig, Wolfgang Meyerhof
The recent advances in the functional expression of TAS2Rs in heterologous systems resulted in the identification of bitter tastants that specifically activate receptors of this family. All bitter taste receptors reported to date exhibit a pronounced selectivity for single substances or structurally related bitter compounds. In the present study we demonstrate the expression of the hTAS2R14 gene by RT-PCR analyses and in situ hybridisation in human circumvallate papillae. By functional expression in HEK-293T cells we show that hTAS2R14 displays a, so far, unique broad tuning towards a variety of structurally diverse bitter compounds, including the potent neurotoxins, (-)-alpha-thujone, the pharmacologically active component of absinthe, and picrotoxinin, a poisonous substance of fishberries...
June 25, 2004: Biochemical and Biophysical Research Communications
L Berggren
Van Gogh was during his last years exposed to several potentially toxic substances such as; bromides, lead, camphor and terpene oils in absinthe liquor. All of them produce signs of toxicity which are similar to the symptoms known from van Gogh's attacks of illness; hallucinations, confusion, delirium, convulsions and agitation. However, the many interpretations of van Gogh's illness and state of mind have in most cases not taken into account the possible influence of toxic chemicals.
1997: Svensk Medicinhistorisk Tidskrift
K M Höld, N S Sirisoma, T Ikeda, T Narahashi, J E Casida
Alpha-thujone is the toxic agent in absinthe, a liqueur popular in the 19th and early 20th centuries that has adverse health effects. It is also the active ingredient of wormwood oil and some other herbal medicines and is reported to have antinociceptive, insecticidal, and anthelmintic activity. This study elucidates the mechanism of alpha-thujone neurotoxicity and identifies its major metabolites and their role in the poisoning process. Four observations establish that alpha-thujone is a modulator of the gamma-aminobutyric acid (GABA) type A receptor...
April 11, 2000: Proceedings of the National Academy of Sciences of the United States of America
J Strang, W N Arnold, T Peters
No abstract text is available yet for this article.
December 18, 1999: BMJ: British Medical Journal
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