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https://www.readbyqxmd.com/read/28212765/ivermectin-therapy-for-papulopustular-rosacea-and-periorificial-dermatitis-in-children-a-series-of-15-cases
#1
Lucero Noguera-Morel, Paula Gerlero, Antonio Torrelo, Ángela Hernández-Martín
No abstract text is available yet for this article.
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28192466/descriptive-study-of-plant-resources-in-the-context-of-the-ethnomedicinal-relevance-of-indigenous-flora-a-case-study-from-toli-peer-national-park-azad-jammu-and-kashmir-pakistan
#2
Muhammad Shoaib Amjad, Mirza Faisal Qaeem, Israr Ahmad, Sami Ullah Khan, Sunbal Khalil Chaudhari, Nafeesa Zahid Malik, Humaira Shaheen, Arshad Mehmood Khan
BACKGROUND: This paper presents the first quantitative ethnobotanical study of the flora in Toli Peer National Park of Azad Jammu and Kashmir, Pakistan. Being a remote area, there is a strong dependence by local people on ethnobotanical practices. Thus, we attempted to record the folk uses of the native plants of the area with a view to acknowledging and documenting the ethnobotanical knowledge. The aims of the study were to compile an inventory of the medicinal plants in the study area and to record the methods by which herbal drugs were prepared and administered...
2017: PloS One
https://www.readbyqxmd.com/read/28191680/friends-or-foes-host-defense-antimicrobial-peptides-and-proteins-in-human-skin-diseases
#3
REVIEW
François Niyonsaba, Chanisa Kiatsurayanon, Panjit Chieosilapatham, Hideoki Ogawa
Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28186635/diversification-of-rosaceae-since-the-late-cretaceous-based-on-plastid-phylogenomics
#4
Shu-Dong Zhang, Jian-Jun Jin, Si-Yun Chen, Mark W Chase, Douglas E Soltis, Hong-Tao Li, Jun-Bo Yang, De-Zhu Li, Ting-Shuang Yi
Phylogenetic relationships in Rosaceae have long been problematic because of frequent hybridisation, apomixis and presumed rapid radiation, and their historical diversification has not been clarified. With 87 genera representing all subfamilies and tribes of Rosaceae and six of the other eight families of Rosales (outgroups), we analysed 130 newly sequenced plastomes together with 12 from GenBank in an attempt to reconstruct deep relationships and reveal temporal diversification of this family. Our results highlight the importance of improving sequence alignment and the use of appropriate substitution models in plastid phylogenomics...
February 10, 2017: New Phytologist
https://www.readbyqxmd.com/read/28183148/ten-year-incidence-and-prevalence-of-clinically-diagnosed-blepharitis-in-south-korea-a-nationwide-population-based-cohort-study
#5
Tyler Hyungtaek Rim, Min Jae Kang, Moonjung Choi, Kyoung Yul Seo, Sung Soo Kim
IMPORTANCE: Blepharitis is one of the most common conditions. However, no study has yet evaluated the epidemiology by evaluating a large population-based sample. BACKGROUND: To evaluate the incidence and prevalence of clinically diagnosed blepharitis in South Korea. DESIGN: Nationwide population-based study. PARTICIPANTS: We investigated the Korean National Health Insurance Service-National Sample Cohort, a representative 1 million-sample of the Korean population, for patients diagnosed with blepharitis according to the Korean Classification of Diseases...
February 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28178365/development-and-clinical-validation-of-a-novel-photography-based-skin-erythema-evaluation-system-a-comparison-with-the-calculated-consensus-of-dermatologists
#6
M Cho, D-H Lee, E J Doh, Y Kim, J H Chung, H C Kim, S Kim
Erythema is the most common presenting sign of skin conditions [1,2]. Erythema reflects the degree of inflammation associated with various diseases, such as atopic dermatitis, psoriasis, and lupus erythematosus; it is also cosmetically troublesome in subjects with flushing, rosacea, and photoaging [3,4]. In addition, there are vascular disorders that present with erythema, such as nevus flammeus, telangiectasia, and post-acne erythema [5]. Various therapeutic devices, medicines, and cosmetics have been developed to improve these dermatological conditions [6,7]...
February 8, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28170535/activation-of-p38-and-erk-mitogen-activated-protein-kinases-signaling-in-ocular-rosacea
#7
Edward J Wladis, Supraja Swamy, Alyssa Herrmann, Jinhong Yang, J Andrew Carlson, Alejandro P Adam
Purpose: Rosacea-related cutaneous inflammation is a common cause of ocular surface disease. Currently, there are no specific pharmacologic therapies to treat ocular rosacea. Here, we aimed at determining the differences in intracellular signaling activity in eyelid skin from patients with and without ocular rosacea. Methods: This was an observational, comparative case series including 21 patients undergoing lower lid ectropion surgery at one practice during 2013 and 2014 (18 patients with rosacea, 13 control patients), and 24 paraffin-embedded archival samples from Albany Medical Center, selected randomly (12 patients with rosacea, 12 control patients)...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28168623/a-report-of-two-cases-of-solid-facial-edema-in-acne
#8
Sarah Kuhn-Régnier, Joanna Mangana, Katrin Kerl, Jivko Kamarachev, Lars E French, Antonio Cozzio, Alexander A Navarini
INTRODUCTION: Solid facial edema (SFE) is a rare complication of acne vulgaris. To examine the clinical features of acne patients with solid facial edema, and to give an overview on the outcome of previous topical and systemic treatments in the cases so far published. METHODS: We report two cases from Switzerland, both young men with initially papulopustular acne resistant to topical retinoids. RESULTS: Both cases responded to oral isotretinoin, in one case combined with oral steroids...
February 6, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28165377/erythroid-differentiation-regulator-1-as-a-novel-biomarker-for-hair-loss-disorders
#9
Yu Ri Woo, Sewon Hwang, Seo Won Jeong, Dae Ho Cho, Hyun Jeong Park
Erythroid differentiation regulator 1 (Erdr1) is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Skin samples from 21 patients with hair loss disorders and five control subjects were retrieved, in order to assess their expression levels of Erdr1. Results revealed that expression of Erdr1 was significantly downregulated in the epidermis and hair follicles of patients with hair loss disorders, when compared to that in the control group...
February 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28164731/regulatory-modulatory-effect-of-prune-essence-concentrate-on-intestinal-function-and-blood-lipids
#10
Hui-Fang Chiu, Yun-Chien Huang, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Oksana Golovinskaia, Kamesh Venkatakrishnan, Chin-Kun Wang
CONTEXT: Prunus domestica Linn (Rosaceae) has been considered a functional food, owing to its various pharmacological activities, including antioxidant, anti-inflammatory, antidiabetic and anticancer. OBJECTIVE: This placebo-controlled, randomized study was framed to check the beneficial activity of prune essence concentrates (PEC) in corroboration with intestinal function and lipid profile in mildly hypercholesterolemic subjects. MATERIALS AND METHODS: Sixty healthy mild hypercholesterolemic subjects were randomly chosen and segregated into three groups as placebo (consume 50 mL of simulated prune drink), PEC I (consume 50 mL of PEC/day) and PEC II (consume 100 mL of PEC/day) for 4 weeks with 2 weeks of follow-up without PEC consumption...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28158318/the-first-complete-chloroplast-genome-sequences-of-ulmus-species-by-de-novo-sequencing-genome-comparative-and-taxonomic-position-analysis
#11
Li-Hui Zuo, Ai-Qin Shang, Shuang Zhang, Xiao-Yue Yu, Ya-Chao Ren, Min-Sheng Yang, Jin-Mao Wang
Elm (Ulmus) has a long history of use as a high-quality heavy hardwood famous for its resistance to drought, cold, and salt. It grows in temperate, warm temperate, and subtropical regions. This is the first report of Ulmaceae chloroplast genomes by de novo sequencing. The Ulmus chloroplast genomes exhibited a typical quadripartite structure with two single-copy regions (long single copy [LSC] and short single copy [SSC] sections) separated by a pair of inverted repeats (IRs). The lengths of the chloroplast genomes from five Ulmus ranged from 158,953 to 159,453 bp, with the largest observed in Ulmus davidiana and the smallest in Ulmus laciniata...
2017: PloS One
https://www.readbyqxmd.com/read/28158242/de-novo-characterization-of-micrornas-in-oriental-fruit-moth-grapholita-molesta-and-selection-of-reference-genes-for-normalization-of-microrna-expression
#12
Xiu Wang, Yisong Li, Jing Zhang, Qingwen Zhang, Xiaoxia Liu, Zhen Li
MicroRNAs (miRNAs) are a group of endogenous non-coding small RNAs that have critical regulatory functions in almost all known biological processes at the post-transcriptional level in a variety of organisms. The oriental fruit moth Grapholita molesta is one of the most serious pests in orchards worldwide and threatens the production of Rosacea fruits. In this study, a de novo small RNA library constructed from mixed stages of G. molesta was sequenced through Illumina sequencing platform and a total of 536 mature miRNAs consisting of 291 conserved and 245 novel miRNAs were identified...
2017: PloS One
https://www.readbyqxmd.com/read/28150340/four-cases-of-morbihan-disease-successfully-treated-with-doxycycline
#13
Ayaka Okubo, Kazuhiro Takahashi, Toshihide Akasaka
Morbihan disease (MD) is rosacea-like disease characterized by persistent lymphedema on the upper half of the face. Currently, there is no established standard treatment for MD. Recently, MD has been reported to be associated with the infiltration of mast cells. The aim of this study was to investigate the association of treatment response and mast cell infiltration in MD. We report four cases of MD that were successfully treated with long-term oral doxycycline therapy.
February 2, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28150107/acne-and-rosacea
#14
REVIEW
Mauro Picardo, Lawrence F Eichenfield, Jerry Tan
Acne, one of the most common skin diseases, affects approximately 85% of the adolescent population, and occurs most prominently at skin sites with a high density of sebaceous glands such as the face, back, and chest. Although often considered a disease of teenagers, acne is occurring at an increasingly early age. Rosacea is a chronic facial inflammatory dermatosis characterized by flushing (or transient facial erythema), persistent central facial erythema, inflammatory papules/pustules, and telangiectasia. Both acne and rosacea have a multifactorial pathology that is incompletely understood...
January 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28146364/antimutagenic-antirecombinogenic-and-antitumor-effect-of-amygdalin-in-a-yeast-cell-based-test-and-mammalian-cell-lines
#15
Atanaska Todorova, Margarita Pesheva, Ivan Iliev, Krum Bardarov, Teodora Todorova
Amygdalin is a major component of the seeds of Rosaceae family of plants such as apricots, peaches, cherry, nectarines, apples, plums, and so on, as well as almonds. It is used in alternative medicine for cancer prevention, alleviation of fever, cough suppression, and quenching thirst. The aim of the present study is to determine the mutagenic and recombinogenic effects of amygdalin in a test system Saccharomyces cerevisiae and to evaluate its potential antitumor effect in a yeast cell-based test and colon cancer cell lines...
February 1, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28139145/a-case-report-of-combination-treatment-with-potassium-titanyl-phosphate-laser-and-brimonidine-topical-gel-in-erythematotelangiectatic-rosacea
#16
M A Hofmann, G Kokolakis
Laser therapies have been shown to provide symptom improvement in patients with erythema and telangiectasia of rosacea; however, they are associated with side effects such as erythema. Combinatorial treatment with pharmacological agents and laser have demonstrated better efficacy, fewer side effects and continued long-term remission compared with monotherapies. A case of moderate facial erythema that responded well to combination treatment with brimonidine 3 mg/g gel and a treatment course of potassium-titanyl phosphate (KTP) laser therapy is presented, showing a reduction from baseline, maintained after final laser session, by applying brimonidine 3 mg/g gel daily...
January 31, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28137259/effect-of-the-topical-application-of-an-ethanol-extract-of-quince-seeds-on-the-development-of-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#17
Takeshi Kawahara, Kanako Tsutsui, Eri Nakanishi, Toshifumi Inoue, Yasunori Hamauzu
BACKGROUND: Quince (Cydonia oblonga Miller) is a deciduous shrub belonging to the Rosaceae family. Quince seed extract has long been used as a cosmetic ingredient for its moisturizing effect. However, little is known about whether quince seed extract has therapeutic effects on keratinocyte-associated skin inflammation. METHODS: In the present study, we investigated the effect of the topical application of ethanol extract of quince seeds (QSEtE) on atopic dermatitis (AD) symptoms in NC/Nga mice...
January 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28132878/emerging-strategies-for-the-diagnosis-and-treatment-of-meibomian-gland-dysfunction-proceedings-of-the-ocean-group-meeting
#18
Gerd Geerling, Christophe Baudouin, Pasquale Aragona, Maurizio Rolando, Kostas G Boboridis, José M Benítez-Del-Castillo, Yonca A Akova, Jesús Merayo-Lloves, Marc Labetoulle, Martin Steinhoff, Elisabeth M Messmer
Meibomian gland dysfunction (MGD) is a common and chronic disorder that has a significant adverse impact on patients' quality of life. It is a leading cause of evaporative dry eye disease (DED), as meibomian glands play an important role in providing lipids to the tear film, which helps to retard the evaporation of tears from the ocular surface. MGD is also often present in conjunction with primary aqueous-deficient DED. Obstructive MGD, the most commonly observed type of MGD, is the main ocus of this article...
January 26, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28131815/sebaceous-gland-rich-skin-is-characterized-by-tslp-expression-and-distinct-immune-surveillance-which-is-disturbed-in-rosacea
#19
Zsolt Dajnoki, Gabriella Béke, Anikó Kapitány, Gábor Mócsai, Krisztián Gáspár, Ralph Rühl, Zoltán Hendrik, István Juhász, Christos C Zouboulis, Attila Bácsi, Tamás Bíró, Dániel Törőcsik, Andrea Szegedi
The microbial community exhibits remarkable diversity on topographically distinct skin regions, which may be accompanied by differences in skin immune characteristics. Our aim was to compare the immune milieu of healthy sebaceous gland rich (SGR) and sebaceous gland poor (SGP) skin areas, and to analyze its changes in an inflammatory disease of SGR skin. For this purpose, immunohistochemical, immunocytochemical and quantitative real-time PCR analyses of thymic stromal lymphopoietin (TSLP) and other cytokines, phenotypic immune cell markers and transcription factors were carried out in samples from SGP, SGR skin and from papulopustular rosacea (PPR)...
January 25, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28131793/rosacea-and-risk-of-cancer-in-denmark
#20
Alexander Egeberg, Joseph F Fowler, Gunnar H Gislason, Jacob P Thyssen
BACKGROUND: Rosacea is a common facial skin disorder with an estimated prevalence of 5-10% among Caucasians. OBJECTIVE: We compared cancer incidence in patients previously diagnosed with rosacea with that in the general population. METHODS: Nationwide cohort study of the Danish population using individual-level linkage of administrative registers. All Danish citizens aged ≥18years were followed from January 1st 2008 to December 31st 2012...
January 26, 2017: Cancer Epidemiology
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