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https://www.readbyqxmd.com/read/29146842/genome-sequences-of-19-novel-erwinia-amylovora-bacteriophages
#1
Ian N D Esplin, Jordan A Berg, Ruchira Sharma, Robert C Allen, Daniel K Arens, Cody R Ashcroft, Shannon R Bairett, Nolan J Beatty, Madeline Bickmore, Travis J Bloomfield, T Scott Brady, Rachel N Bybee, John L Carter, Minsey C Choi, Steven Duncan, Christopher P Fajardo, Brayden B Foy, David A Fuhriman, Paul D Gibby, Savannah E Grossarth, Kala Harbaugh, Natalie Harris, Jared A Hilton, Emily Hurst, Jonathan R Hyde, Kayleigh Ingersoll, Caitlin M Jacobson, Brady D James, Todd M Jarvis, Daniella Jaen-Anieves, Garrett L Jensen, Bradley K Knabe, Jared L Kruger, Bryan D Merrill, Jenny A Pape, Ashley M Payne Anderson, David E Payne, Malia D Peck, Samuel V Pollock, Micah J Putnam, Ethan K Ransom, Devin B Ririe, David M Robinson, Spencer L Rogers, Kerri A Russell, Jonathan E Schoenhals, Christopher A Shurtleff, Austin R Simister, Hunter G Smith, Michael B Stephenson, Lyndsay A Staley, Jason M Stettler, Mallorie L Stratton, Olivia B Tateoka, P J Tatlow, Alexander S Taylor, Suzanne E Thompson, Michelle H Townsend, Trever L Thurgood, Brittian K Usher, Kiara V Whitley, Andrew T Ward, Megan E H Ward, Charles J Webb, Trevor M Wienclaw, Taryn L Williamson, Michael J Wells, Cole K Wright, Donald P Breakwell, Sandra Hope, Julianne H Grose
Erwinia amylovora is the causal agent of fire blight, a devastating disease affecting some plants of the Rosaceae family. We isolated bacteriophages from samples collected from infected apple and pear trees along the Wasatch Front in Utah. We announce 19 high-quality complete genome sequences of E. amylovora bacteriophages.
November 16, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29126172/native-honey-bees-outperform-adventive-honey-bees-in-increasing-pyrus-bretschneideri-rosales-rosaceae-pollination
#2
Tolera Kumsa Gemeda, Youquan Shao, Wenqin Wu, Huipeng Yang, Jiaxing Huang, Jie Wu
The foraging behavior of different bee species is a key factor influencing the pollination efficiency of different crops. Most pear species exhibit full self-incompatibility and thus depend entirely on cross-pollination. However, as little is known about the pear visitation preferences of native Apis cerana (Fabricius; Hymenoptera: Apidae) and adventive Apis mellifera (L.; Hymenoptera: Apidae) in China. A comparative analysis was performed to explore the pear-foraging differences of these species under the natural conditions of pear growing areas...
November 6, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29125745/fruit-seeds-of-the-rosaceae-family-a-waste-new-life-or-a-danger-to-human-health
#3
Mateja Senica, Franci Stampar, Robert Veberic, Maja Mikulic-Petkovsek
In fruit production seeds are mostly regarded a waste, but for plants they represent a beginning of new life. Seeds accumulate toxic or health-beneficial compounds and the elucidation of their metabolic profile is especially important to people who consume the entire fruit, including the seeds. The present research quantifies the levels of bioactive compounds (phenolics and cyanogenic glycosides (CGG)) in fruit seeds of 35 cultivars belonging to 6 different fruit species. High-performance liquid chromatography and mass spectrophotometry were used to detect and identify the studied compounds...
November 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29120271/apple-polyphenol-suppresses-indomethacin-induced-gastric-damage-in-experimental-animals-by-lowering-oxidative-stress-status-and-modulating-the-mapk-signaling-pathway
#4
Yi-Chen Lee, Chun-Wen Cheng, Huei-Jane Lee, Huei-Chuien Chu
Indomethacin is a nonsteroid anti-inflammatory drug (NSAID) that is used to alleviate pain and inflammation in clinical medicine. Previous studies indicated that NSAIDs can cause gastrointestinal mucosal complications, and it is associated with mucosal lipid peroxidation and oxidative damage. Based on the evidences, decreasing oxidative stress may be an ideal therapeutic strategy for preventing gastrointestinal ulcer. Apple (Rosaceae Malus sp.) is one of the most commonly consumed fruits worldwide. The abundant polyphenolic constituents have received increasing attention for decades...
November 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29107339/comorbidities-in-rosacea-a-systematic-review-and-update
#5
REVIEW
Roger Haber, Maria El Gemayel
BACKGROUND: Rosacea is linked to abnormalities of cutaneous vasculature and dysregulation of the inflammatory response. Recent reports on rosacea have shown a significant association with cardiovascular, gastrointestinal, and psychiatric diseases, all of which may affect morbidity and mortality among these patients. OBJECTIVE: To review available data regarding comorbidities associated with rosacea, discuss their pathogenesis, and highlight the evaluation of affected patients...
October 26, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29104721/topical-a-agonist-therapy-for-persistent-facial-erythema-of-rosacea-and-the-addition-of-oxmetazoline-to-the-treatment-armamentarium-where-are-we-now
#6
REVIEW
James Q Del Rosso
The presence of vasoactivity in rosacea-affected skin led to the development of two topical α-adrenergic receptor agonists, brimonidine tartrate 0.5% gel and oxymetazoline hydrochloride 1% cream, both approved by the United States Food and Drug Administration for treatment of persistent facial erythema of rosacea. In this article, the author discusses challenges related to the treatment of persistent facial erythema of rosacea and the use of a-agonist therapy. The author also discusses cases of worsening of facial erythema after the application of brimonidine, as well as briefly reviews recently reported clinical data on oxymetazoline...
July 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29102687/rosacea-comorbidities-and-future-research-the-2017-update-by-the-national-rosacea-society-expert-committee
#7
EDITORIAL
Richard L Gallo, Richard D Granstein, Sewon Kang, Mark Mannis, Martin Steinhoff, Jerry Tan, Diane Thiboutot
No abstract text is available yet for this article.
November 1, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29094614/role-of-topical-oxymetazoline-for-management-of-erythematotelangiectatic-rosacea
#8
Rebecca M Hoover, John Erramouspe
OBJECTIVE: To review and summarize topical oxymetazoline's pharmacology, pharmacokinetics, efficacy, safety, cost, and place in therapy for persistent redness associated with erythematotelangiectatic rosacea. DATA SOURCES: Literature searches of MEDLINE (1975 to September 2017), International Pharmaceutical Abstracts (1975 to September 2017), and Cochrane Database (publications through September 2017) using the terms rosacea, persistent redness, α -agonist, and oxymetazoline...
November 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29093758/tgtt-and-aaca-two-transcriptionally-active-ltr-retrotransposon-subfamilies-with-a-specific-ltr-structure-and-horizontal-transfer-in-four-rosaceae-species
#9
Hao Yin, Xiao Wu, Dongqing Shi, Yangyang Chen, Kaijie Qi, Zhengqiang Ma, Shaoling Zhang
Background: Long terminal repeat retrotransposons (LTR-RTs) are major components of plant genomes. Common LTR-RTs contain the palindromic dinucleotide 5'-'TG'-'CA'-3' motif at the ends. Thus, further analyses of non-canonical LTR-RTs with non-palindromic motifs will enhance our understanding of their structures and evolutionary history. Results: Here, we report two new LTR-RT subfamilies (TGTT and AACA) with atypical dinucleotide ends of 5'-'TG'-'TT'-3', and 5'-'AA'-'CA'-3' in pear, apple, peach and mei...
2017: Mobile DNA
https://www.readbyqxmd.com/read/29091565/rosacea
#10
REVIEW
Esther J van Zuuren
New England Journal of Medicine, Volume 377, Issue 18, Page 1754-1764, November 2017.
November 2, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29091380/real-world-efficacy-of-azelaic-acid-15-gel-for-the-reduction-of-inflammatory-lesions-of-rosacea
#11
P J Wirth, M H Henderson Berg, N Sadick
Approximately 16 million Americans have rosacea, an inflammatory cutaneous disorder with central facial erythema, papules, pustules, telangiectasia, flushing, and swelling being among the more commonly recognized features. Overexpression of cathelicidin peptide LL-37 has been implicated in the pathophysiology of rosacea. Azelaic acid has been found to inhibit the pathologic expression of cathelicidin, as well as the hyperactive protease activity that cleaves cathelicidin into LL-37. Given these findings, a small prospective, open-label, interventional trial was undertaken to assess the effects of azelaic acid 15% gel on inflammatory lesions of papulopustular rosacea in a real-world setting...
November 2017: Skin Therapy Letter
https://www.readbyqxmd.com/read/29090055/severe-rosacea-a-case-report
#12
Ebrahim Shirzadeh, Abbas Bagheri, Mojtaba Fattahi Abdizadeh, Mozhgan Rezaei Kanavi
PURPOSE: To describe a case of severe rosacea with ocular involvement. CASE REPORT: A 28-year-old female patient presented with extensive facial and ocular eruptions. She had a history of treatment with oral prednisolone due to the clinical diagnosis of lupus erythematosus (LE), which had resulted in transient improvement of the lesions, but was followed by exacerbation of the lesions. With the clinical diagnosis of severe oculofacial rosacea, she was successfully treated with oral doxycycline, steroid eye drops, and ocular lubricants...
October 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29089181/evidence-based-update-on-rosacea-comorbidities-and-their-common-physiologic-pathways
#13
REVIEW
Anna D Holmes, Julia Spoendlin, Anna L Chien, Hilary Baldwin, Anne Lynn S Chang
Rosacea is a common chronic inflammatory disease affecting the facial skin whose etiology and pathophysiology are the subject of much investigation. Risk factors include genetic and environmental elements that may predispose individuals to localized inflammation and abnormal neurovascular responses to stimuli. Recent studies have introduced an array of systemic rosacea comorbidities, such as inflammatory bowel disease and neurologic conditions, that can be challenging to synthesize. We critically review the current data behind reported rosacea comorbidities and identify and highlight underrecognized physiologic mediators shared among rosacea and associated comorbidities...
October 28, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29089180/standard-classification-and-pathophysiology-of-rosacea-the-2017-update-by-the-national-rosacea-society-expert-committee
#14
REVIEW
Richard L Gallo, Richard D Granstein, Sewon Kang, Mark Mannis, Martin Steinhoff, Jerry Tan, Diane Thiboutot
In 2002, the National Rosacea Society assembled an expert committee to develop the first standard classification of rosacea. This original classification was intended to be updated as scientific knowledge and clinical experience increased. Over the last 15 years, significant new insights into rosacea's pathogenesis and pathophysiology have emerged, and the disorder is now widely addressed in clinical practice. Growing knowledge of rosacea's pathophysiology has established that a consistent multivariate disease process underlies the various clinical manifestations of this disorder, and the clinical significance of each of these elements is increasing as more is understood...
October 28, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29077044/inhibition-of-human-kallikrein-5-protease-by-triterpenoids-from-natural-sources
#15
Yosuke Matsubara, Takashi Matsumoto, Junichi Koseki, Atsushi Kaneko, Setsuya Aiba, Kenshi Yamasaki
Stratum corneum tryptic enzyme kallikrein 5 (KLK5) is a serine protease that is involved in the cell renewal and maintenance of the skin barrier function. The excessive activation of KLK5 causes an exacerbation of dermatoses, such as rosacea and atopic dermatitis. Some triterpenoids are reported to suppress the serine proteases. We aimed to investigate whether bioactive triterpenoids modulate the KLK5 protease. Nineteen triterpenoids occurring in medicinal crude drugs were evaluated using an enzymatic assay to measure the anti-KLK5 activity...
October 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29071268/development-of-ocular-rosacea-following-combined-ipilimumab-and-nivolumab-treatment-for-metastatic-malignant-skin-melanoma
#16
Niels J Brouwer, John B A G Haanen, Martine J Jager
PURPOSE: To report a case of severe ocular rosacea following ipilimumab plus nivolumab treatment in a patient with metastatic malignant skin melanoma. METHODS: Case report and review of the literature. RESULTS: A 68-year-old male with newly diagnosed metastatic malignant cutaneous melanoma was treated with first-line ipilimumab plus nivolumab, which resulted in a partial response. Four months after initiation of treatment, the patient developed red eyelids and conjunctivae, with painful gritty eyes, limiting his capacity to read...
September 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29050447/uncaria-tomentosa
#17
Valentina Della Valle
Uncaria tomentosa (U. tomentosa) or uña de gato, a species of vine of Rubiaceae family, was used from centuries in various medical conditions. Although there are no randomized controlled trials or published human outcome studies, some conditions reportedly improved by U. tomentosa include osteoarthritis, rheumatoid arthritis, prostatitis, viral illnesses and cancer (acting as a non-specific immunomodulantign agent) and it may also have potential as an immunomodulating adaptogen in cellular aging. The understanding of some specific mechanisms of molecular action leads to the demonstration of various anti-inflammatory, immunostimulating and protective effects...
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29038917/chromatin-associated-regulation-of-sorbitol-synthesis-in-flower-buds-of-peach
#18
Alba Lloret, Amparo Martínez-Fuentes, Manuel Agustí, María Luisa Badenes, Gabino Ríos
PpeS6PDH gene is postulated to mediate sorbitol synthesis in flower buds of peach concomitantly with specific chromatin modifications. Perennial plants have evolved an adaptive mechanism involving protection of meristems within specialized structures named buds in order to survive low temperatures and water deprivation during winter. A seasonal period of dormancy further improves tolerance of buds to environmental stresses through specific mechanisms poorly known at the molecular level. We have shown that peach PpeS6PDH gene is down-regulated in flower buds after dormancy release, concomitantly with changes in the methylation level at specific lysine residues of histone H3 (H3K27 and H3K4) in the chromatin around the translation start site of the gene...
October 16, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/29038765/the-complete-chloroplast-genome-sequence-of-strawberry-fragaria-%C3%A2-%C3%A3-%C3%A2-ananassa-duch-and-comparison-with-related-species-of-rosaceae
#19
Hui Cheng, Jinfeng Li, Hong Zhang, Binhua Cai, Zhihong Gao, Yushan Qiao, Lin Mi
Compared with other members of the family Rosaceae, the chloroplast genomes of Fragaria species exhibit low variation, and this situation has limited phylogenetic analyses; thus, complete chloroplast genome sequencing of Fragaria species is needed. In this study, we sequenced the complete chloroplast genome of F. × ananassa 'Benihoppe' using the Illumina HiSeq 2500-PE150 platform and then performed a combination of de novo assembly and reference-guided mapping of contigs to generate complete chloroplast genome sequences...
2017: PeerJ
https://www.readbyqxmd.com/read/29036710/a-disulfide-bond-a-like-oxidoreductase-is-a-strong-candidate-gene-for-self-incompatibility-in-apricot-prunus-armeniaca-pollen
#20
Juan Vicente Muñoz-Sanz, Elena Zuriaga, María L Badenes, Carlos Romero
S-RNase based gametophytic self-incompatibility (SI) is a widespread prezygotic reproductive barrier in flowering plants. In the Solanaceae, Plantaginaceae and Rosaceae gametophytic SI is controlled by the pistil-specific S-RNases and the pollen S-locus F-box proteins but non-S-specific factors, namely modifiers, are also required. In apricot, Prunus armeniaca (Rosaceae), we previously mapped two pollen-part mutations that confer self-compatibility in cultivars Canino and Katy at the distal end of chromosome 3 (M-locus) unlinked to the S-locus...
September 25, 2017: Journal of Experimental Botany
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