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https://www.readbyqxmd.com/read/29332715/prevalence-of-gastrointestinal-comorbidities-in-rosacea-comparison-of-subantimicrobial-modified-release-doxycycline-versus-conventional-release-doxycycline
#1
Hester Gail Lim, Alexander Fischer, Maria Jose Rueda, James Kendall, Sewon Kang, Anna L Chien
No abstract text is available yet for this article.
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29330632/inate-immunity-in-rosacea-langerhans-cells-plasmacytoid-dentritic-cells-toll-like-receptors-and-inducible-oxide-nitric-synthase-inos-expression-in-skin-specimens-case-control-study
#2
Ana Karina Alves Moura, Fernanda Guedes, Maria Cecília Rivitti-Machado, Mirian N Sotto
Rosacea is a chronic inflammatory condition with predominant facial involvement. Because of that, many patients sense that rosacea affects quality of life. The etiology of rosacea remains unknown. Recent studies have suggested that aberrant innate immunity is central to this disease. The aim of this study was to examine the presence of Langerhans cells, plasmacytoid dentritic cells (PDC), the expression of Toll-like receptors (TLR) and inducible oxide nitric synthase (iNOS) in skin of patients with rosacea, to highlight the participation of innate immunity in its pathogenesis...
January 12, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29321878/asymmetric-reproductive-interference-the-consequences-of-cross-pollination-on-reproductive-success-in-sexual-apomictic-populations-of-potentilla-puberula-rosaceae
#3
Christoph Dobeš, Susanne Scheffknecht, Yulia Fenko, Dagmar Prohaska, Christina Sykora, Karl Hülber
Apomixis evolves from a sexual background and usually is linked to polyploidization. Pseudogamous gametophytic apomicts, which require a fertilization to initiate seed development, of various ploidy levels frequently co-occur with their lower-ploid sexual ancestors, but the stability of such mixed populations is affected by reproductive interferences mediated by cross-pollination. Thereby, reproductive success of crosses depends on the difference in ploidy levels of mating partners, that is, on tolerance of deviation from the balanced ratio of maternal versus paternal genomes...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29320594/pivotal-trial-of-the-efficacy-and-safety-of-oxymetazoline-cream-1-0-for-the-treatment-of-persistent-facial-erythema-associated-with-rosacea-findings-from-the-first-reveal-trial
#4
Leon H Kircik, Janet DuBois, Zoe Diana Draelos, Philip Werschler, Kimberly Grande, Fran E Cook-Bolden, Emily Weng, David R Berk, Gurpreet Ahluwalia
An unmet need exists for a safe, tolerable, effective treatment for moderate to severe persistent facial erythema in patients with rosacea. This pivotal phase 3, multicenter, double-blind study evaluated the efficacy and safety of topical oxymetazoline in patients with facial erythema associated with moderate to severe rosacea. Patients were randomly assigned to treatment with oxymetazoline hydrochloride cream 1.0% or vehicle applied once daily for 29 days, and were followed for 28 days posttreatment. The primary efficacy outcome was having at least a 2-grade decrease from baseline on both the Clinician Erythema Assessment (CEA) and the Subject Self-Assessment for rosacea facial redness (SSA) scales (composite success) at 3, 6, 9, and 12 hours postdose on day 29...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29286838/patients-self-esteem-before-and-after-chemical-peeling-procedure
#5
Kouris Anargyros, Platsidaki Eftychia, Christodoulou Christos, Efstathiou Vasiliki, Markantoni Vasiliki, Armyra Kaliopi, Potouridou Irene, Rigopoulos Dimitrios, Kontochristopoulos George
INTRODUCTION: Chemical peeling is a safe method, widely used to treat a variety of skin conditions and reduce the aging effects. This study aims to evaluate self-esteem among adolescents who undergo chemical peelings. MATERIAL AND METHODS: One hundred and twenty six patients constituted the study group. Sixty seven individuals had undergone chemical peeling for therapeutic reasons and 59 individuals for cosmetic reasons. To assess patients' self-esteem, the Rosenberg's Self-esteem Scale (RSES) was used before and after treatment...
December 29, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29283459/characterization-of-the-facial-microbiome-in-twins-discordant-for-rosacea
#6
Asifa K Zaidi, Katrina Spaunhurst, Daniel Sprockett, Y Thomason, M W Mann, P Fu, C Ammons, M Gerstenblith, M S Tuttle, D L Popkin
Previously, we determined that genetic and environmental factors contributed equally towards rosacea in twins. To assess an environmental factor, we characterized the malar cheek bacterial microbiome from twins discordant for rosacea. We found no significant difference in facial microbiome alpha and beta diversity between related twins discordant for rosacea. However, the relative percentage abundance of Gordonia and Geobacillus, low abundant genera, was positively and negatively associated with rosacea severity, respectively...
December 28, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/29283119/demodex-and-rosacea-is-there-a-relationship
#7
Diana Gonzalez-Hinojosa, Alejandro Jaime-Villalonga, Gustavo Aguilar-Montes, Lorena Lammoglia-Ordiales
PURPOSE: The objective of the study is to compare the frequency of Demodex on the eyelash follicle of patients with rosacea and referents without rosacea or ophthalmological disorders. METHODS: This is a comparative, open, observational, and cross-sectional study that included 41 patients diagnosed with rosacea and 41 referents without rosacea diagnosis or ophthalmic alterations. The individuals underwent a slit-lamp examination in which two eyelashes per eyelid were removed with fine forceps...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29258279/preserving-traditional-botanical-knowledge-the-importance-of-phytogeographic-and-ethnobotanical-inventory-of-peruvian-dye-plants
#8
José Mostacero León, Segundo E López Medina, Helmut Yabar, Jordan De La Cruz Castillo
Abstract: Peru is a megadiverse country with native species of all kinds, including dye plants, which have been used for hundreds of years by the local population. Despite the fact that many of these natural dyes are of a superior quality compared to synthetic ones and do not have the harmful effects that the latter may cause to human health, due to the lack of documentation and dissemination, ethnobotanical knowledge is unfortunately being lost with the passing of generations. In order to preserve and spread such valuable knowledge, this study conducted a comprehensive taxonomic, phytogeographic, and ethnobotanical inventory of dye plants based on periodical botanical explorations in selected locations of Northern Peru during the span of two decades...
December 18, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29249250/-what-s-new-in-pediatric-dermatology
#9
C Chiaverini
The year 2017 in pediatric dermatology was marked by several consensus recommendations and meta analyzes on childhood psoriasis, atopic dermatitis or PHACE syndrome, case series on the role of anti-JAK treatment in adolescent with alopecia areata, sirolimus for vascular malformations, ivermectine for rosacea, inhibitors of MEK for type 1 neurofibromatosis or on the side effects of the oral isotretinoin for acne or propranolol for immature hemangioma. Only few randomized controlled studies have been published on the interest of adalimumab in the treatment of psoriasis or topical sirolimus for angiofibroma in tuberous sclerosis complex for example...
December 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29241760/miscellaneous-skin-disease-and-the-metabolic-syndrome
#10
Sila Seremet, Mehmet Salih Gurel
The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29240866/pityriasis-folliculorum-response-to-topical-ivermectin
#11
Kavita Darji, Nicole M Burkemper
<p>Pityriasis folliculorum has been described as a dry type of rosacea with extensive proliferation of Demodex folliculorum in pilosebaceous follicles of the skin. This skin condition is frequently difficult to manage, with various treatment options showing mixed efficacy. Oral ivermectin, a macrocyclic lactone parasiticide with anti-inflammatory and anti-parasitic effects, is one of the leading treatment modalities for demodicosis. Topical ivermectin has recently been FDA approved as therapy for rosacea...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29240857/the-latest-drugs-and-small-molecule-inhibitors-for-skin-and-hair
#12
Varun Kalhun, Neil Sadick
<p>Biologic drugs, a novel class of agents engineered to target specifc mediators of infammation, and small-molecule inhibitors that pen-etrate the cell membrane to interact with targets inside a cell represent the cutting-edge of pharmacological biomedical therapeutics. Clinical studies have already demonstrated the effectiveness of this new generation of drugs in treating a variety of medical illnesses and conditions that were refractory to traditional treatments. This review aims to describe the latest available or currently in-develop-ment drugs, biologic agents, and small molecule inhibitors for treatment of psoriasis, rosacea, alopecia areata, and atopic dermatitis...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29231061/the-effect-of-aqueous-extract-of-rosa-damascena-on-formaldehyde-induced-toxicity-in-mice-testes
#13
Majid Askaripour, Azam Hasanpour, Foruzan Hosseini, Mojgan Moshrefi, Gholamreza Moshtaghi, Mohammad Hasannejad, Soodeh Rajabi, Seyed Noureddin Nematollahi-Mahani
CONTEXT: Rosa damascena L. (Rosaceae) (RD) essential oil and extracts are commonly used as a flavour in herbal medicine which increase libido. Previous studies have shown inhalation of RD flower's oil increases libido and causes protective effects in formaldehyde (FA)-induced testicular damage. OBJECTIVE: The protective effects of aqueous extract of RD on the male reproductive system of mice were examined following FA-induced damage. MATERIALS AND METHODS: Forty-eight adult NMRI male mice were randomly assigned to six groups (n = 8): control (normal saline, 10 mg/kg); RD40 (40 mg/kg, p...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29224039/state-of-the-art-lasers-and-light-treatments-for-vascular-lesions-from-red-faces-to-vascular-malformations
#14
Manuel Valdebran, Brent Martin, Kristen M Kelly
Notable milestones in the treatment of vascular lesions have been achieved over the past century. Many cutaneous vascular lesions can be successfully treated with lightbased devices. In this review, we will discuss the treatment of port-wine birthmarks, lymphatic malformations, infantile hemangiomas, rosacea, venous lakes, pyogenic granulomas, cherry angiomas, and angiofibromas using lasers, total reflection amplification of spontaneous emission of radiation, intense pulsed light, and photodynamic therapy. In addition, for several of these diagnoses, we will review medical therapies that can be combined with light-based devices to provide enhanced results...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29217229/idiopathic-facial-aseptic-granuloma-clinical-and-ultrasound-findings-in-3-cases
#15
A I Rodríguez-Bandera, M Feito-Rodríguez, R Maseda-Pedrero, R de Lucas-Laguna
Idiopathic facial aseptic granuloma is a typical childhood disease characterized by the presence of one or more asymptomatic nodules on the cheek. Although pathogenesis remains unclear, the disease is thought to be a type of childhood rosacea. It resolves spontaneously, yet it could be confused with other lesions that require treatment. We present clinical and ultrasound findings and outcome from 3 new cases. In 2 cases, the lesion presented as childhood rosacea. Ultrasound revealed a characteristic pattern, with variations depending on the stage of development...
December 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29216377/peachvar-db-a-curated-collection-of-genetic-variations-for-the-interactive-analysis-of-peach-genome-data
#16
Marco Cirilli, Tiziano Flati, Silvia Gioiosa, Ilario Tagliaferri, Angelo Ciacciulli, Zhongshan Gao, Stefano Gattolin, Filippo Geuna, Francesco Maggi, Paolo Bottoni, Laura Rossini, Daniele Bassi, Tiziana Castrignanò, Giovanni Chillemi
Applying next-generation sequencing (NGS) technologies to species of agricultural interest has the potential to accelerate the understanding and exploration of genetic resources. The storage, availability and maintenance of huge quantities of NGS-generated data remains a major challenge. The PeachVar-DB portal, available at http://hpc-bioinformatics.cineca.it/peach, is an open-source catalogue of genetic variants present in peach (P. persica L. Batsch) and wild-related species of Prunus genera, annotated from 146 samples publicly released on the Sequence Reads Archive (SRA)...
December 4, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29215880/neuroprotective-effects-of-1-2-diarylpropane-type-phenylpropanoid-enantiomers-from-red-raspberry-against-h2o2-induced-oxidative-stress-in-human-neuroblastoma-sh-sy5y-cells
#17
Le Zhou, Guo-Dong Yao, Xiao-Yu Song, Jie Wang, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song
Red raspberry (Rubus idaeus L.) is an edible fruit-producing species belonging to the Rosaceae family. In our search for the health-promoting constituents from this fruit, four pairs of enantiomeric phenylpropanoids (1a/1b-4a/4b), including three new compounds (1a and 2a/2b), were isolated from red raspberry. Their structures were elucidated by a combination of the extensive NMR spectroscopic data analyses, HRESIMS and comparison between the experimental measurements of electronic circular dichroism (ECD) and calculated ECD spectra by time-dependent density functional theory (TDDFT)...
December 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29214107/diet-and-rosacea-the-role-of-dietary-change-in-the-management-of-rosacea
#18
REVIEW
Emma Weiss, Rajani Katta
Dietary change may play a role in the therapy of rosacea. Certain foods and beverages may act as "triggers" for rosacea exacerbations. These may be divided into heat-related, alcohol-related, capsaicin-related, and cinnamaldehyde-related. One potential pathogenic mechanism may be via the activation of transient receptor potential cation channels, which result in neurogenic vasodilatation. Further research is needed on the role of the gut skin connection in rosacea. Epidemiologic studies suggest that patients with rosacea have a higher prevalence of gastrointestinal disease, and one study reported improvement in rosacea following successful treatment of small intestinal bacterial overgrowth...
October 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29194776/endosymbiosis-and-its-significance-in-dermatology
#19
REVIEW
Katarzyna Kubiak, Hanna Sielawa, Wenchieh Chen, Ewa Dzika
Proposed at the beginning of the 20th to explain the origin of eukaryotic organelles from prokaryotes, endosymbiosis is now medically defined by various interaction patterns between microorganisms and their residing hosts, best exemplified by the bacterial endosymbiont Wolbachia identified in arthropods and filarial nematodes, which can influence normal development, reproduction, survival, and transmission of the hosts. Based on the transmission modes, vertical or horizontal, and the function of the endosymbionts, the host-symbiont dependence can be divided into primary or secondary...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29182532/human-skin-permeation-studies-with-ppar%C3%AE-agonist-to-improve-its-permeability-and-efficacy-in-inflammatory-processes
#20
Marcelle Silva-Abreu, Lupe Carolina Espinoza, María José Rodríguez-Lagunas, María-José Fábrega, Marta Espina, María Luisa García, Ana Cristina Calpena
Rosacea is the most common inflammatory skin disease. It is characterized by erythema, inflammatory papules and pustules, visible blood vessels, and telangiectasia. The current treatment has limitations and unsatisfactory results. Pioglitazone (PGZ) is an agonist of peroxisome proliferator-activated receptors (PPARs), a nuclear receptor that regulates important cellular functions, including inflammatory responses. The purpose of this study was to evaluate the permeation of PGZ with a selection of penetration enhancers and to analyze its effectiveness for treating rosacea...
November 28, 2017: International Journal of Molecular Sciences
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