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https://www.readbyqxmd.com/read/28736585/late-onset-asymptomatic-pancreatic-neuroendocrine-tumor-a-case-report-on-the-phenotypic-expansion-for-men1
#1
Charu Kaiwar, Sarah K Macklin, Jennifer M Gass, Jessica Jackson, Eric W Klee, Stephanie L Hines, John A Stauffer, Paldeep S Atwal
BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a hereditary cancer syndrome associated with several endocrine as well as non-endocrine tumors and is caused by mutations in the MEN1 gene. Primary hyperparathyroidism affects the majority of MEN1 individuals by age 50 years. Additionally, MEN1 mutations trigger familial isolated hyperparathyroidism. We describe a seemingly unaffected 76-year-old female who presented to our Genetics Clinic with a family history of primary hyperparathyroidism and the identification of a pathogenic MEN1 variant...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/28731232/a-comprehensive-review-of-agrimoniin
#2
REVIEW
Daniel M Grochowski, Krystyna Skalicka-Woźniak, Ilkay Erdogan Orhan, Jianbo Xiao, Marcello Locatelli, Jakub P Piwowarski, Sebastian Granica, Michał Tomczyk
Plant tannins are a unique class of polyphenols with relatively high molecular weights. Within the ellagitannins group, agrimoniin--dimeric ellagitannin--is one of the most representative compounds found in many plant materials belonging to the Rosaceae family. Agrimoniin was first isolated in 1982 from roots of Agrimonia pilosa Ledeb. (Rosaceae), a plant traditionally used in Japan and China as an antidiarrheal, hemostatic, and antiparasitic agent. Agrimoniin is a constituent of medicinal plants, which are often applied orally in the form of infusions, decoctions, or tinctures...
July 21, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28729872/plc-mediated-signaling-pathway-in-pollen-tubes-regulates-the-gametophytic-self-incompatibility-of-pyrus-species
#3
Haiyong Qu, Yaqin Guan, Yongzhang Wang, Shaolin Zhang
Among the Rosaceae species, the gametophytic self-incompatibility (GSI) is controlled by a single multi-allelic S locus, which is composed of the pistil-S and pollen-S genes. The pistil-S gene encodes a polymorphic ribonuclease (S-RNase), which is essential for identifying self-pollen. However, the S-RNase system has not been fully characterized. In this study, the self-S-RNase inhibited the Ca(2+)-permeable channel activity at pollen tube apices and the selectively decreased phospholipase C (PLC) activity in the plasma membrane of Pyrus pyrifolia pollen tubes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28728857/-rosacea-new-data-for-better-care
#4
B Cribier
In the last 10 years, numerous studies have been published that throw new light on rosacea, in all areas of the disease. This overview summarises all the key developments, based on the indexed bibliography appearing in Medline between 2007 and 2017. Recent epidemiological data show that the prevalence of the disease is doubtless greater than estimated hitherto (more than 10% of adults in some countries) and that we should not overlook rosacea in subjects with skin phototypes V or VI, a condition that exists on all continents...
July 17, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28711190/role-of-demodex-mite-infestation-in-rosacea-a-systematic-review-and-meta-analysis
#5
Yin-Shuo Chang, Yu-Chen Huang
BACKGROUND: The reported prevalence and degrees of Demodex mite infestation in rosacea vary widely. OBJECTIVE: We sought to conduct an evidence-based meta-analysis of the prevalence and degrees of Demodex mite infestation in patients with rosacea. METHODS: Systematic literature review and meta-analysis were conducted. Odds ratios for prevalence of infestation and standardized mean difference (SMD) for Demodex density in patients with rosacea were pooled...
July 12, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28710586/bud-sprouting-and-floral-induction-and-expression-of-ft-in-loquat-eriobotrya-japonica-thunb-lindl
#6
Carmina Reig, Francisco Gil-Muñoz, Francisco Vera-Sirera, Ana García-Lorca, Amparo Martínez-Fuentes, Carlos Mesejo, Miguel A Pérez-Amador, Manuel Agustí
EjFT1 and EjFT2 genes were isolated and sequenced from leaves of loquat. EjFT1 is involved in bud sprouting and leaf development, and EjFT2 in floral bud induction. Loquat [Eriobotrya japonica (Thunb.) Lindl.] is an evergreen species belonging to the family Rosaceae, such as apple and pear, whose reproductive development, in contrast with these species, is a continuous process that is not interrupted by winter dormancy. Thus, the study of the mechanism of flowering in loquat has the potential to uncover the environmental and genetic networks that trigger flowering more accurately, contributing for a better understanding of the Rosaceae floral process...
July 14, 2017: Planta
https://www.readbyqxmd.com/read/28702966/possible-role-of-helicobacter-pylori-in-diseases-of-dermatological-interest
#7
C Guarneri, J Lotti, M Fioranelli, M G Roccia, T Lotti, F Guarneri
Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. pylori infection were suggested in diseases of dermatological interest such as chronic urticaria, rosacea, Henoch-Schoenleins purpura, idiopathic thrombocytopenic purpura, cutaneous and oral lichen planus, atopic dermatitis, recurrent aphthous stomatitis, systemic sclerosis, psoriasis, Sjögrens syndrome, Behçet's disease, pruritus, alopecia areata, primary cutaneous marginal zone B-cell lymphomas, vitiligo, chronic prurigo, multiformis, prurigo nodularis, leukocytoclastic vasculitis, prurigo pigmentosa, eczema nummulare, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, Sweet's syndrome, cutaneous T-cell pseudolymphoma and pemphigus vulgaris...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28698821/an-observational-descriptive-survey-of-rosacea-in-the-chinese-population-clinical-features-based-on-the-affected-locations
#8
Hong-Fu Xie, Ying-Xue Huang, Lin He, Sai Yang, Yu-Xuan Deng, Dan Jian, Wei Shi, Ji Li
BACKGROUND: There is currently no study that has evaluated the differences in epidemiological and clinical characteristics among rosacea patients according to different facial sites. METHODS: Clinical and demographic data were obtained from 586 rosacea patients. The patients were divided into four groups based on the main sites involved with the rosacea lesions (full-face, cheeks, nose, or perioral involvement). Clinical signs were measured through self-reported, dermatologist-evaluated grading of symptoms, and physiological indicators of epidermal barrier function...
2017: PeerJ
https://www.readbyqxmd.com/read/28696955/pediatric-blepharokeratoconjunctivitis-is-there-a-right-treatment
#9
Sepideh T Rousta
PURPOSE OF REVIEW: This article highlights the importance of recognizing blepharokeratoconjunctivitis (BKC) in children and reviews the clinical characteristics and current therapeutic modalities. RECENT FINDINGS: The mainstay of BKC treatment remains controlling the meibomian gland inflammation and treating cobormid conditions. BKC can occur in the setting of ocular rosacea and Demodex infestation. Small studies have shown treatment benefits of topical cyclosporine A as well as oral azithromycin in pediatric BKC...
July 10, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28695265/conservation-of-erwinia-amylovora-pathogenicity-relevant-genes-among-erwinia-genomes
#10
Luigimaria Borruso, Marco Salomone-Stagni, Ivan Polsinelli, Armin Otto Schmitt, Stefano Benini
The Erwinia genus comprises species that are plant pathogens, non-pathogen, epiphytes, and opportunistic human pathogens. Within the genus, Erwinia amylovora ranks among the top 10 plant pathogenic bacteria. It causes the fire blight disease and is a global threat to commercial apple and pear production. We analyzed the presence/absence of the E. amylovora genes reported to be important for pathogenicity towards Rosaceae within various Erwinia strains genomes. This simple bottom-up approach, allowed us to correlate the analyzed genes to pathogenicity, host specificity, and make useful considerations to drive targeted studies...
July 10, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28690630/lack-of-s-rnase-based-gametophytic-self-incompatibility-in-orchids-suggests-that-this-system-evolved-after-the-monocot-eudicot-split
#11
Shan-Ce Niu, Jie Huang, Yong-Qiang Zhang, Pei-Xing Li, Guo-Qiang Zhang, Qing Xu, Li-Jun Chen, Jie-Yu Wang, Yi-Bo Luo, Zhong-Jian Liu
Self-incompatibility (SI) is found in approximately 40% of flowering plant species and at least 100 families. Although orchids belong to the largest angiosperm family, only 10% of orchid species present SI and have gametophytic SI (GSI). Furthermore, a majority (72%) of Dendrobium species, which constitute one of the largest Orchidaceae genera, show SI and have GSI. However, nothing is known about the molecular mechanism of GSI. The S-determinants of GSI have been well characterized at the molecular level in Solanaceae, Rosaceae, and Plantaginaceae, which use an S-ribonuclease (S-RNase)-based system...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28686779/efficacy-and-tolerability-of-a-cosmetic-skin-care-product-with-trans-4-t-butylcyclohexanol-and-licochalcone-a-in-subjects-with-sensitive-skin-prone-to-redness-and-rosacea
#12
Zorica Jovanovic, Nariman Angabini, Sonja Ehlen, Zrinka Bukvic Mokos, Milica Subotic, Gitta Neufang
<p>BACKGROUND: Sensitive skin and rosacea are skin conditions, which may affect the quality of life of the patients considerably. In vitro and in vivo data indicated that the combination of trans-t-butylcyclohexanol and licochalcone A is an effective combination for alleviating the increased sensitivity of rosacea subtype I.</p> <p>OBJECTIVE: Objective of this open dermocosmetic study was to investigate the efficacy and tolerability of a skin care product containing the anti-inflammatory licochalcone A and the TRPV1 antagonist trans-t-butylcyclohexanol in subjects with sensitive skin prone to redness and rosacea...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28686772/a-pilot-double-blind-placebo-controlled-study-to-assess-the-efficacy-and-safety-of-incobotulinumtoxina-injections-in-the-treatment-of-rosacea
#13
Steven H Dayan, Nazanin Ashourian, Katherine Cho
<p>BACKGROUND: Rosacea has a variable presentation. Whereas the pathophysiology may differ, erythema, and flushing are the most consistent findings in all patients.</p> <p>OBJECTIVE: To evaluate the safety and efficacy of incobotulinumtoxinA in reducing the severity of rosacea symptoms.</p> <p>METHODS: Nine subjects with erythematotelangiectactic or papulopustular rosacea were randomized in 2 groups. Subjects in Group 1 (n=4) received up to a total of 20 U of incobotulinumtoxinA in the affected area (across both cheeks)...
June 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28679382/ethnopharmacological-survey-of-home-remedies-used-for-treatment-of-hair-and-scalp-and-their-methods-of-preparation-in-the-west-bank-palestine
#14
Abdel Naser Zaid, Nidal Amin Jaradat, Ahmad Mustafa Eid, Hamzeh Al Zabadi, Abdulsalam Alkaiyat, Saja Adam Darwish
BACKGROUND: Natural products have many uses and purposes, including those linked to pharmaceutics and cosmetics. The aim of this study was to investigate the use of natural remedies for the treatment of hair and scalp disorders in the West Bank, Palestine. METHODS: An ethnopharmacological survey of herbal remedies and other natural products used in cosmetics and cosmeceuticals was carried out in the West Bank, Palestine. A questionnaire was distributed to 267 herbalists, traditional healers, hairdressers and rural dwellers...
July 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28674614/an-efp-browser-for-visualizing-strawberry-fruit-and-flower-transcriptomes
#15
Charles Hawkins, Julie Caruana, Jiaming Li, Chris Zawora, Omar Darwish, Jun Wu, Nadim Alkharouf, Zhongchi Liu
Wild strawberry Fragaria vesca is emerging as an important model system for the cultivated strawberry due to its diploid genome and availability of extensive transcriptome data and a range of molecular genetic tools. Being able to better utilize these tools, especially the transcriptome data, will greatly facilitate research progress in strawberry and other Rosaceae fruit crops. The electronic fluorescent pictograph (eFP) software is a useful and popular tool to display transcriptome data visually, and is widely used in other model organisms including Arabidopsis and mouse...
2017: Horticulture Research
https://www.readbyqxmd.com/read/28667759/experiences-of-rosacea-and-its-treatment-an-interpretative-phenomenological-analysis
#16
S A Johnston, M Krasuska, A Millings, A C Lavda, A R Thompson
BACKGROUND: Whilst rosacea is a chronic skin condition, the condition can often have a large psychosocial impact on the individual. There is therefore a need to understand the experience of living with rosacea from the patient perspective. OBJECTIVES: To examine the experience of living with rosacea and the experience of seeking and receiving treatment. METHODS: Nine participants took part in semi-structured interviews, which were analysed using interpretative phenomenological analysis...
July 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28663757/genome-wide-analysis-suggests-the-relaxed-purifying-selection-affect-the-evolution-of-wox-genes-in-pyrus-bretschneideri-prunus-persica-prunus-mume-and-fragaria-vesca
#17
Yunpeng Cao, Yahui Han, Dandan Meng, Guohui Li, Dahui Li, Muhammad Abdullah, Qing Jin, Yi Lin, Yongping Cai
WUSCHEL-related homeobox (WOX) family is one of the largest group of transcription factors (TFs) specifically found in plant kingdom. WOX TFs play an important role in plant development processes and evolutionary novelties. Although the roles of WOXs in Arabidopsis and rice have been well-studied, however, little are known about the relationships among the main clades in the molecular evolution of these genes in Rosaceae. Here, we carried out a genome-wide analysis and identified 14, 10, 10, and 9 of WOX genes from four Rosaceae species (Fragaria vesca, Prunus persica, Prunus mume, and Pyrus bretschneideri, respectively)...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28659135/bilateral-morganella-morganii-keratitis-in-a-patient-with-facial-topical-corticosteroid-induced-rosacea-like-dermatitis-a-case-report
#18
Bei Zhang, Fei Pan, Kejian Zhu
BACKGROUND: Bilateral keratitis rarely occurs in individuals without predisposing factors. Here we describe the clinical course of a patient who developed a bilateral keratitis caused by Morganella. morganii which might be associated with long term using of topical corticosteroids-containing preparations on the face. CASE PRESENTATION: A 52-year-old female patient presented with marked bilateral corneal infiltration and hypopyon without any usual predisposing factors for bilateral infectious keratitis...
June 28, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28656562/diagnosis-and-treatment-of-rosacea-fulminans-a-comprehensive-review
#19
REVIEW
Rabina K Walsh, Alyson A Endicott, Kanade Shinkai
Rosacea fulminans is a rare inflammatory condition of the central face marked by the abrupt onset of erythematous coalescing papules, pustules, nodules, and draining sinuses. Due to infrequent reporting in the literature, the pathophysiology, classification, and nomenclature of this condition remain controversial. This comprehensive review evaluated a total of 135 cases of rosacea fulminans for clinical and histopathologic features and reported treatment strategies. Patients were 91% female with an average age of onset of 31...
June 27, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28653460/dual-anti-inflammatory-and-antiparasitic-action-of-topical-ivermectin-1-in-papulopustular-rosacea
#20
M Schaller, L Gonser, K Belge, C Braunsdorf, R Nordin, A Scheu, C Borelli
BACKGROUND: Recently, therapy of rosacea with inflammatory lesions (papulopustular) has improved substantially with the approval of topical ivermectin 1% cream. It is assumed to have a dual mode of action with anti-inflammatory capacities and anti-parasitic effect against Demodex, which however has not yet been demonstrated in vivo. AIM: To find scientific rationale for the dual anti-inflammatory and anti-parasitic mode of action of topical ivermectin 1% cream in patients with rosacea...
June 27, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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