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Artemisia absinthium toxicity

Vanessa Andreu, Annabel Levert, Anaïs Amiot, Anaïs Cousin, Nicolas Aveline, Cédric Bertrand
Five plant extracts traditionally used in organic and biodynamic farming for pest control and antifungal (downy mildew) disease management were selected after a farmer survey and analyzed for their chemical composition in LC-PDA-MS-MS and using adapted analytical method from food chemistry for determination of class of component (e.g., protein, sugar, lipids…). Their antifungal activity against Penicillium expansum, Botrytis cinerea, Botrytis allii, brown rot causing agents (Monilinia laxa and Monilinia fructigena), and grape downy mildew (Plasmopara viticola) was examined in vitro...
March 7, 2018: Environmental Science and Pollution Research International
Agnieszka Fischer, Barbara Brodziak-Dopierała, Krzysztof Loska, Jerzy Stojko
Heavy metals polluting the natural environment are absorbed by plants. The use of herbs as components of cosmetics may pose a health risk for humans. The aim of the study was to determine the concentrations of Pb, Cd and Hg in selected species of herbs (horsetail Equisetum arvense , nettle Urtica dioica , St. John's wort Hypericum perforatum , wormwood Artemisia absinthium , yarrow Achillea millefolium , cottonwood Solidago virgaurea ) self-collected from the natural environment in two different locations, and purchased in stores on the territory of Poland...
October 24, 2017: International Journal of Environmental Research and Public Health
Mubashir Hussain, Naveed Iqbal Raja, Zia-Ur-Rehman Mashwani, Muhammad Iqbal, Sidra Sabir, Farhat Yasmeen
In the recent years, nanotechnology has attained much attention in the every field of science. The synthesis, characterisation and applications of metallic nanoparticles (MNPs) have become an important branch of nanotechnology. In the current study, MNPs were synthesised through polyols process and applied in vitro to study their effect on medicinally important plant : Artemisia absinthium. The current study strives to check the effect of MNPs, i.e., Ag, Cu and Au on seed germination, root and shoot length, seedling vigour index (SVI) and biochemical profiling in A...
June 2017: 3 Biotech
Niko S Radulović, Marija S Genčić, Nikola M Stojanović, Pavle J Randjelović, Zorica Z Stojanović-Radić, Nenad I Stojiljković
Neurotoxic thujones (α- and β-diastereoisomers) are common constituents of plant essential oils. In this study, we employed a statistical approach to determine the contribution of thujones to the overall observed behaviour-modulating and toxic effects of essential oils (Salvia officinalis L., Artemisia absinthium L., Thuja occidentalis L. and Tanacetum vulgare L.) containing these monoterpene ketones. The data from three in vivo neuropharmacological tests on rats (open field, light-dark, and diazepam-induced sleep), and toxicity assays (brine shrimp, and antimicrobial activity against a panel of microorganisms), together with the data from detailed chemical analyses, were subjected to a multivariate statistical treatment to reveal the possible correlation(s) between the content of essential-oil constituents and the observed effects...
July 2017: Food and Chemical Toxicology
Zuriyadda Sakipova, Nikki Siu Hai Wong, Tolkyn Bekezhanova, Sadykova, Alma Shukirbekova, Fabio Boylan
Santonin, a powerful anthelmintic drug that was formely used to treat worms, is Artemisia cina's main constituent. However, due to its toxicity to humans, it is no longer in use. Kazakhstan is looking to introduce this plant as an anthelmintic drug for veterinary purposes, despite the known toxic properties of the santonin. The objective of this study was to develop a fast and specific method for the identification of santonin and its precise quantitation using HPLC-UV in order to avoid unnecessary intoxication, which is paramount for the development of veterinary medicines...
2017: PloS One
Marimuthu Govindarajan, Giovanni Benelli
The eco-friendly control of mosquito vectors is a crucial challenge of public health importance. Here we evaluated the larvicidal potential of Artemisia absinthium essential oil (EO) and its three major chemical constituents against six mosquito vectors: Anopheles stephensi, Anopheles subpictus, Aedes aegypti, Aedes albopictus, Culex quinquefasciatus, and Culex tritaeniorhynchus. The EO was obtained by leaf hydro-distillation. Its chemical composition was analyzed using gas chromatography-mass spectrometry...
December 2016: Parasitology Research
Abid Ali, Khalilur Rahman, Nazish Jahan, Amer Jamil, Abid Rashid, Syed Muhammad Ali Shah
Medicinal plants are rich in secondary metabolites (alkoloids, glycosides, coumarins, flavonides, steroids, etc.) and considered to be more effective and a safer alternative source to manage a variety of diseases related to liver, heart and kidney disordered. This study determines in vitro antioxidant and in vivo toxicological profile including hemolytic, brine shrimp lethality and mutagenicity of aerial parts of Artemisia absinthium. DNA protection assay was performed on pUC19 plasmid vector using H(2)O(2) as oxidative agent...
January 2016: Pakistan Journal of Pharmaceutical Sciences
Nadeem Mohani, Mansoor Ahmad, - Mehjabeen, Noor Jahan
Qualitative and quantitative analysis of plant extracts can be achieved by using different spectroscopic techniques. In current research work we deal with the nature of the absorption and spectra of extract of Acorus calamus, Artemisia absinthium and Bergenia himalaica using FTIR spectroscopic technique. The present study was focused on standardization of crude extracts by utilization of infrared light. The spectra of crude extracts (A. calamus, A. absinthium and B. himalaica) displayed very clear diagnostic peaks of functional groups i...
November 2014: Pakistan Journal of Pharmaceutical Sciences
Tatjana Mihajilov-Krstev, Boris Jovanović, Jovana Jović, Budimir Ilić, Dragoljub Miladinović, Jelena Matejić, Jelena Rajković, Ljubiša Dorđević, Vladimir Cvetković, Bojan Zlatković
In this paper, the chemical composition and biological activity of the essential oil of Artemisia absinthium was studied. The aim of this study was to investigate the potential of ethnopharmacological uses of this plant species in the treatment of gastrointestinal diseases and wounds, and as an insect repellent. The aerial part of the plant was hydrodistilled, and the chemical composition of the essential oil was analyzed by gas chromatography and gas chromatography/mass spectrometry. Forty-seven compounds, corresponding to 94...
December 2014: Planta Medica
Tsegabirhan Kifleyohannes, Getachew Terefe, Yacob H Tolossa, Mirutse Giday, Nigatu Kebede
BACKGROUND: Treatment of trypanosomosis is currently facing a number of problems including toxicity of trypanocidal drugs and development of resistance by the parasites. These limitations have prompted the search for alternative active substances (such as of natural origin). The purpose of the study was to investigate the effect of extracts of Moringa stenopetala and Artemisia absinthium on Trypanosoma congolense in mice. METHODS: Swiss white male mice aged 8-12 weeks were divided into six experimental groups of six animals...
2014: BMC Research Notes
Yves Chapuis
Absinthe (Artemisia absinthium) has been known for its medicinal properties since Antiquity. The Egyptians in 1600 BC, then Hippocrates, Galien, The Salerne School in 1649, and 18th-century physicians all recommended it for a variety of maladies. In 1780-1790 in Switzerland (Val de Travers), a traditional healer and, probably, a itinerant physician by the name of Docteur Ordinaire, transformed this purgative elixir into an aperitif liqueur, a move followed by two centuries of unexpected success. Absinthe was manufactured in France, at Pontarlier, for tax reasons...
February 2013: Bulletin de L'Académie Nationale de Médecine
Monika Saxena, Sangeeta Shukla
In the present study, we evaluated the protective activity of an aqueous extract of Artemisia absinthium against CCl4-induced hepatic damage in rats. The protective activity of this extract at three doses (2.5, 5, and 10 ml/ kg, once orally) against CCl4-induced oxidative damage (1.5 ml/kg, once intraperitoneally) in rats was analyzed. Various blood and tissue biochemical studies were performed, and the administration of the toxicant significantly altered blood biochemical variables. Hepatic lipid peroxidation (LPO) was significantly elevated, whereas glutathione (GSH) level was considerable depleted after intoxication...
2012: Journal of Environmental Pathology, Toxicology and Oncology
Ayse Nalbantsoy, Sura Baykan Erel, Cinel Köksal, Bayram Göçmen, Mehmet Zülfü Yıldız, Nefise Ülkü Karabay Yavaşoğlu
The present study was conducted to explore the characterization of Montivipera xanthina crude venom partially by in vitro and in vivo and the anti-snake venom activities of Artemisia absinthium L. in comparison with carrageenan-induced acute inflammation model in rats. The LD50 value was estimated as 8.78 mg/kg within 24 h by different venom doses administrated intraperitoneally in mice. The IC50 value was 0.43 ± 0.18 μg/ml after 48 h treatment while the calculated value was 0.73 ± 0.10 μg/ml for the culture media totally refreshed after 2 h treatment with venom...
April 2013: Toxicon: Official Journal of the International Society on Toxinology
Lana Dvorkin-Camiel, Julia S Whelan
The increasingly diverse U.S. immigrant populations and the growing use of medicinal herbs create a need for health care professionals to expand their knowledge in this area. This is a review of tropical plants, Annona Muricata, Artemisia absinthium, Cinchona officinalis, Illicium verum, Momordica charantia, Opuntia streptacantha, Schinus terebinthifolius, and Tabebuia avellanedae (impetiginosa), commonly used by Latino and Haitian populations for the treatment of infectious disease. All the eight plants discussed here have one or more of the following: antibacterial, antiviral, antifungal, or antiparasitic properties...
2008: Journal of Dietary Supplements
Yinebeb Tariku, Ariaya Hymete, Asrat Hailu, Jens Rohloff
Potential toxicity, costs, and drug-resistant pathogens necessitate the development of new antileishmanial agents. Medicinal and aromatic plants constitute a major source of natural organic compounds. In this study, essential oils of Artemisia absinthium L. and Echinops kebericho Mesfin were investigated by GC and GC/MS analyses. Isolated oils were screened for antileishmanial activity against two Leishmania strains (L. aethiopica and L. donovani), and toxicity on the human monocytic leukemia (THP-1) cell line and red blood cells in vitro...
April 2011: Chemistry & Biodiversity
O Kharoubi, M Slimani, A Aoues, L Seddik
The ability of Wormwood (Artemisia absinthium L.) extract (A.Ab) to restore membrane-bound enzymes like Na(+)-K(+)-ATPase, Ca(++)-ATPase, Mg(++)-ATPase, and oxidative damage induced by lead were investigated. Rats were exposed to lead acetate (750 ppm) for 11-weeks and treated during 4-weeks with A.Ab. Lipid levels, ATPase activity, thiobarbituric acid reactive substances (TBARS), and proteins carbonyl were estimated. In liver and kidney, lead acetate inhibited membrane-bound enzymes and increased (P < 0...
April 2008: Indian Journal of Nephrology
Fernando Calzada, Ramón Arista, Halley Pérez
ETHNOPHARMACOLOGICAL RELEVANCE: A total of 28 plant extracts, belonging to 26 different plant species are commonly used in Traditional Mexican Medicine for the treatment of gastrointestinal disorders such as diarrhea. AIM OF THE STUDY: To evaluate the effect of medicinal plant extracts on induced hyperperistalsis in rats. MATERIALS AND METHODS: Charcoal meal test was used in this study. Extracts were tested at a dose of 300mg/kg. RESULTS: From all the plant extracts tested, only Geranium mexicanum (roots) showed 100% of inhibition...
March 2, 2010: Journal of Ethnopharmacology
Slavica Razić, Svetlana Dogo, Latinka Slavković
Trace and major elements were determined in medicinal herbs (Cynara scolymus, Matricaria chamomilla, Artemisia absinthium L., Achillea millefolium, and Inula britannica) as well as in rhizosphere soil samples. Based on the results obtained after microwave-acid-assisted digestion (nitric acid + hydrogen peroxide) and single-step extraction (ammonium acetate), the real and potential acidity and redox potential of the soils, uptake, mobility, and bioavailability of potassium, calcium, magnesium, iron, manganese, copper, zinc, nickel, chromium, lead, and cadmium are discussed...
July 2008: Journal of Natural Medicines
Dirk W Lachenmeier, Stephan G Walch, Stephan A Padosch, Lars U Kröner
The alcoholic beverage absinthe is recently experiencing a revival after a yearlong prohibition. This review article provides information on all aspects of this bitter spirit and its major components, especially wormwood (Artemisia absinthium L.), which contains the toxic monoterpene thujone. Over 100 references on historic and current literature are provided. The topics comprise the history of the alcoholic drink starting from its invention in the eighteenth century. Historical and modern recipes are discussed in the context of different quality categories and possibilities to reduce the content of thujone are given...
2006: Critical Reviews in Food Science and Nutrition
Tomoko Muto, Takao Watanabe, Miwa Okamura, Mitsuyoshi Moto, Yoko Kashida, Kunitoshi Mitsumori
Wormwood, Artemisia absinthium, is a very bitter plant, and its extract has been used as food additives such as seasonings for food and drinks. A 13-week repeated dose toxicity study of wormwood extract was performed in both sexes of Wistar Hannover (GALAS) rats. Rats were divided into 4 groups consisting of 10 males and 10 females each, and were given water containing 0, 0.125, 0.5, or 2% wormwood extract. All rats had survived at the end of the study, and no changes indicating obvious toxicities that are attributable to the treatment of wormwood extract were observed in the body weights, hematological and serum biochemical examinations, organ weights, and histopathological examinations...
December 2003: Journal of Toxicological Sciences
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