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Mercury toxicity

Mainak Banerjee, Gouriprasanna Roy
We show that the N-methylimidazole-based selone Im(OH)Se having an N-CH2CH2OH substituent has the remarkable ability to degrade methylmercury by two distinct pathways. Under basic conditions, Im(OH)Se converts MeHgCl into biologically inert HgSe nanoparticles and Me2Hg via the formation of an unstable intermediate (MeHg)2Se (pathway I). However, under neutral conditions, in the absence of any base, Im(OH)Se facilitates the cleavage of the Hg-C bond of MeHgCl at room temperature (23 °C), leading to the formation of a stable cleaved product, the tetracoordinated mononuclear mercury compound (Im(OH)Se)2HgCl2 and Me2Hg (pathway II)...
October 12, 2017: Inorganic Chemistry
Pandeeswar Makam, Rohilla Shilpa, Ahmad Esmaielzadeh Kandjani, Selvakannan R Periasamy, Ylias Mohammad Sabri, Chilakapati Madhu, Suresh Kumar Bhargava, Thimmaiah Govindaraju
The development of reliable and ultrasensitive detection marker for mercury ions (Hg(2+)) in drinking water is of great interest for toxicology assessment, environmental protection and human health. Although many Hg(2+) detection methods have been developed, only few offer sensitivities below 1pM. Herein, we describe a simple histidine (H) conjugated perylene diimide (PDI) bolaamphiphile (HPH) as a dual-responsive optical marker to develop highly selective and sensitive probe as visible (sol-to-gel transformation), fluorescence and SERS-based Hg(2+)sensor platform in the water...
October 2, 2017: Biosensors & Bioelectronics
Antonio Ivanildo Pinho, Cláudia Sirlene Oliveira, Fabricio Luís Lovato, Emily Pansera Waczuk, Bruna Candia Piccoli, Aline Augusti Boligon, Nadghia Figueredo Leite, Henrique Douglas Melo Coutinho, Thais Posser, João Batista Teixeira Da Rocha, Jeferson Luis Franco
Mercury (Hg) is widely distributed in the environment and is known to produce several adverse effects in organisms. The aim of the present study was to examine the in vitro antioxidant activity and Hg chelating ability of the hydroalcoholic extract of Psidium guajava leaves (HEPG). In addition, the potential protective effects of HEPG against Hg(II) were evaluated using a yeast model (Saccharomyces cerevisiae). HEPG was found to exert significant antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl scavenger and inhibition of lipid peroxidation induced by Fe(II) assays in a concentration-dependent manner...
October 11, 2017: Journal of Toxicology and Environmental Health. Part A
Caren Weinhouse, Ernesto J Ortiz, Axel J Berky, Paige Bullins, John Hare-Grogg, Laura Rogers, Ana-Maria Morales, Heileen Hsu-Kim, William K Pan
Anemia has been widely studied in global health contexts because of severe nutritional deficiency, and more recently, inflammatory status, but chemical exposures are rarely considered. Until recently, "anemia" was used synonymously with "iron deficiency anemia (IDA)" in global health settings. However, only 50% of anemia cases worldwide are IDA. Environmental toxicology studies of anemia risk have generally focused on populations in developed countries, albeit with high exposure to environmental toxicants, such as lead or cadmium...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
Venkatanaidu Karri, Vikas Kumar, David Ramos, Eliandre Oliveira, Marta Schuhmacher
Heavy metals are considered some of the most toxic environmental pollutants. Exposure to heavy metals including lead (Pb), cadmium (Cd), arsenic (As), and methyl mercury (MeHg) has long been known to cause damage to human health. Many recent studies have supported the hippocampus as the major target for these four metals for inflicting cognitive dysfunction. In the present study, we proposed hippocampal relevant in vitro toxicity of Pb, Cd, As, and MeHg in HT-22 cell line. This study reports, initially, cytotoxic effects in acute, subchronic, chronic exposures...
October 9, 2017: Biological Trace Element Research
Qingxia Duan, Meng Zhang, Chunxia Sheng, Caiyun Liu, Liu Wu, Zhenmin Ma, Qiang Zhao, Zhongpeng Wang, Baocun Zhu
Developing some methods that can simply and effectively detect mercury ions (Hg(2+)) in the environment and biological systems are very important due to the problems of high toxicity and biological accumulation. Herein, we report a simple rhodol-derived colorimetric and fluorescent probe rhodol-Hg with a recognition receptor of carbonothioate for the specific determination of Hg(2+). The color of probe rhodol-Hg solution changed remarkably from colorless to pink in the presence of Hg(2+), thus rhodol-Hg could act as a "naked-eye" probe for Hg(2+)...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Xiaonan Wang, Zhanfei He, Hongwei Luo, Ming Zhang, Daoyong Zhang, Xiangliang Pan, Geoffrey Michael Gadd
Mercury contamination is a global concern because of its high toxicity, persistence, bioaccumulative nature, long distance transport and wide distribution in the environment. In this study, the efficiency and multiple-pathway remediation mechanisms of Hg(2+) by a selenite reducing Escherichia coli was assessed. E. coli can reduce Hg(2+) to Hg(+) and Hg(0) and selenite to selenide at the same time. This makes a multiple-pathway mechanisms for removal of Hg(2+) from water in addition to biosorption. It was found that when the original Hg(2+) concentration was 40μgL(-1), 93...
October 5, 2017: Science of the Total Environment
Tahir Rasheed, Muhammad Bilal, Faran Nabeel, Hafiz M N Iqbal, Chuanlong Li, Yongfeng Zhou
The quest for industrial and biotechnological revolution has been contributed in increasing environmental contamination issues, worldwide. The controlled or uncontrolled release of hazardous pollutants from various industrial sectors is one of the key problems facing humanity. Among them, adverse influences of lead, cadmium, and mercury on human health are well known to cause many disorders like reproductive, neurological, endocrine system, and cardiovascular, etc. Besides their presence at lower concentrations, most of these toxic heavy metals are posing noteworthy toxicological concerns...
October 4, 2017: Science of the Total Environment
Sandra García-Medina, Marcela Galar-Martínez, Leobardo Manuel Gómez-Oliván, Karina Ruiz-Lara, Hariz Islas-Flores, Eloy Gasca-Pérez
Mercury is one of the most toxic metals in aquatic systems since it is able to induce neurobehavioral disorders as well as renal and gastrointestinal tract damage. The common carp Cyprinus carpio is an important species from both an ecological and economic viewpoint as it is consumed in many countries, the top producers being Mexico, China, India and Japan. The present study aimed to evaluate the relation between Hg-induced oxidative stress and genotoxicity in diverse tissues of C. carpio. Specimens were exposed to 0...
September 21, 2017: Aquatic Toxicology
Maria Vadalà, Carmen Laurino, Beniamino Palmieri
AIM: The aim of the study was to evaluate the clinical relevance, sensitivity and specificity of in vitro blood test, Memory Lymphocyte ImmunoStimulation Assay (MELISA(®)), in genetically predisposed patients that suffer by autoimmune/inflammatory syndrome induced by adjuvants, after HPV-vaccination and that could have a high metal hypersensitivity. MATERIALS AND METHODS: Sixteen girls (aged 12-24 years) that developed long-lasting and invalidating somatoform symptoms occurring within 20 days postvaccination are included in this descriptive study...
October 2017: Journal of Laboratory Physicians
Fernanda M Rebelo, Leandro R da Cunha, Patrícia D Andrade, Walkimar A da Costa Junior, Wanderley R Bastos, Eloisa D Caldas
Mercury is a toxic metal, ubiquitous in nature; it is excreted in breast milk from exposed mothers and may affect infant neuro-development. In this study, 224 breast milk samples provided by eight human milk banks in the Federal District of Brazil were analyzed for total mercury (THg), of which 183 were also analyzed for methyl mercury (MeHg), the most relevant form of this metal for the breastfed infants. Samples were acid digested in a microwave oven and THg determined by atomic fluorescence spectrometry (LOQ of 0...
December 2017: Journal of Trace Elements in Medicine and Biology
Danuta I Kosik-Bogacka, Natalia Lanocha-Arendarczyk, Karolina Kot, Zaneta Ciosek, Pawel Zietek, Maciej Karaczun, Bogumila Pilarczyk, Agnieszka Tomza-Marciniak, Joanna Podlasinska, Elzbieta Kalisinska, Joanna Pyzia
Due the long-term nature of joint tissue remodeling processes, knee structures including meniscus and anterior cruciate ligament (ACL) can be a model for studying the bioaccumulation of mercury (Hg) and selenium (Se). The accumulation and retention of Hg in human tissues can have a negative effect on the proper functioning of homeostasis-affecting organisms. A factor of chronic poisoning with Hg forms is probably the Se:Hg ratio in tissues. Se:Hg molar ratios below one may increase Hg toxicity potentials, while molar ratios that approach or exceed one effectively may protect against Hg toxicity...
December 2017: Journal of Trace Elements in Medicine and Biology
Yuting Lu, Danyi Yang, Xiaoni Song, Sheng Wang, Min Song, Taijun Hang
Cinnabar (α-HgS), has been formulated in Traditional Chinese Medicines (TCMs) for thousands of years. Since the total Hg content was accepted widely as the toxicity criteria, the safety alerts have been issued about the cinnabar containing TCMs for exceeding Hg limits. However, cinnabar is almost insoluble in water, the oral absorption is extremely low. Hence, it is not suitable to use the total Hg content alone to evaluate the toxicity of cinnabar containing TCMs. In instead, the bioaccessible Hg is a much reasonable safety indicator...
December 2017: Journal of Trace Elements in Medicine and Biology
Victoria Mesa, Jose L R Gallego, Ricardo González-Gil, Béatrice Lauga, Jesús Sánchez, Celia Méndez-García, Ana I Peláez
Acid mine drainages are characterized by their low pH and the presence of dissolved toxic metallic species. Microorganisms survive in different microhabitats within the ecosystem, namely water, sediments, and biofilms. In this report, we surveyed the microbial diversity within all domains of life in the different microhabitats at Los Rueldos abandoned mercury underground mine (NW Spain), and predicted bacterial function based on community composition. Sediment samples contained higher proportions of soil bacteria (AD3, Acidobacteria), as well as Crenarchaeota and Methanomassiliicoccaceae archaea...
2017: Frontiers in Microbiology
Diana M Narváez, Helena Groot, Sonia M Diaz, Ruth Marien Palma, Nathalia Muñoz, Marie-Pierre Cros, Hector Hernández-Vargas
Mercury (Hg) exposure is a public health concern due to its persistence in the environment and its high toxicity. Such toxicity has been associated with the generation of oxidative stress in occupationally exposed subjects, such as artisanal gold miners. In this study, we characterize occupational exposure to Hg by measuring blood, urine and hair levels, and investigate oxidative stress and DNA methylation associated with gold mining. To do this, samples from 53 miners and 36 controls were assessed. We show higher levels of oxidative stress marker 8-OHdG in the miners...
September 2017: Heliyon
Ya-Ching Huang, Hsiao-Chen Ning, Shang-Syuan Chen, Chia-Ni Lin, I-Kwan Wang, Shu-Man Weng, Cheng-Hao Weng, Ching-Wei Hsu, Wen-Hung Huang, Jang-Jih Lu, Tsu-Lan Wu, Tzung-Hai Yen
This study surveyed urinary nickel concentrations in peritoneal dialysis (PD) patients, and analyzed the association of urinary nickel concentrations with clinical outcomes and inflammatory biomarkers. In total, 50 PD patients and 50 healthy controls were recruited for this study. All participants were examined for the presence of toxic trace elements (antimony, arsenic, bismuth, cadmium, copper, manganese, mercury, nickel, lead, tellurium, thallium and zinc) in their urine by using inductively coupled plasma mass spectrometry (ICP-MS)...
September 1, 2017: Oncotarget
Zhihe Qing, Lixuan Zhu, Xiaoxuan Li, Sheng Yang, Zhen Zou, Jingru Guo, Zhong Cao, Ronghua Yang
As well-known, the excessive discharge of heavy-metal mercury not only destroys the ecological environment, bust also leads to severe damage of human health after ingestion via drinking and bioaccumulation of food chains, and mercury ion (Hg(2+)) is designated as one of most prevalent toxic metal ions in drinking water. Thus, the high-performance monitoring of mercury pollution is necessary. Functional nucleic acids have been widely used as recognition probes in biochemical sensing. In this work, a carbazole derivative, ethyl-4-[3,6-bis(1-methyl-4-vinylpyridium iodine)-9H-carbazol -9-yl)] butanoate (EBCB), has been synthesized and found as a target-lighted DNA fluorescent indicator...
October 3, 2017: Environmental Science & Technology
Weijie Mu, Kun Jia, Yan Liu, Xuming Pan, Yawen Fan
This study investigates the effects of copper and mercury on growth rate, chlorophyll a content, superoxide dismutase (SOD) activity, SOD mRNA gene expression, and frustule morphology of the benthic freshwater diatom Halamphora veneta (Kützing) Levkov and the potential utility of each for toxicity assessment in aquatic habitats. Results showed the following: (1) Compared to mercury, exposure to copper resulted in greater growth inhibition of H. veneta even at low concentrations and after short durations of exposure; (2) high accumulation of chlorophyll a in H...
September 25, 2017: Environmental Science and Pollution Research International
Justin R Perrault, Nicole I Stacy, Andreas F Lehner, Savannah K Poor, John P Buchweitz, Catherine J Walsh
Toxic elements (arsenic, cadmium, lead, mercury, selenium, thallium) are a group of contaminants that are known to elicit developmental, reproductive, general health, and immune system effects in reptiles, even at low concentrations. Reptiles, including marine turtles, are susceptible to accumulation of toxic elements due to their long life span, low metabolic rate, and highly efficient conversion of prey into biomass. The objectives of this study were to (1) document concentrations of arsenic, cadmium, lead, mercury, selenium, and thallium in whole blood and keratin from nesting loggerhead sea turtles (Caretta caretta) from Casey Key, Florida and document correlations thereof and (2) correlate whole blood toxic element concentrations to various hematological and plasma biochemistry analytes...
September 19, 2017: Environmental Pollution
Tong Ding, Jiao-Yang Luo, Xu Han, Shi-Hai Yang, Rui-Chao Lin, Mei-Hua Yang
Cinnabars are widely used in the clinic and shows unique efficacy, and it has been used in treating diseases for thousands of years either single-use or combination with other traditional Chinese medicines. Cinnabar mainly contains mercury, which displays obvious hepatotoxicity and nephrotoxicity. The safety of cinnabar and its rational use caused extensive attention. However, there are some misunderstanding that cinnabar shows equivalent toxicity to the toxicity of mercury compounds such as mercuric chloride and methylmercury in safety evaluation of cinnabar, which in our view exaggerates the toxicity...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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