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Mercury toxicity

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https://www.readbyqxmd.com/read/29230529/sexual-maturity-and-life-stage-influences-toxic-metal-accumulation-in-croatian-brown-bears
#1
Maja Lazarus, Ankica Sekovanić, Tatjana Orct, Slaven Reljić, Jasna Jurasović, Đuro Huber
The influence of reproductive and (early) life stages on toxic metal levels was investigated in the brown bear (Ursus arctos), the largest mammalian predator species in Croatia. The purpose was to examine critical clusters in a population that might be at a higher risk of adverse health effects caused by metals as environmental contaminants. Levels of cadmium, mercury and lead in muscle, liver and kidney cortex of 325 male and 139 female bears, quantified by inductively coupled plasma mass spectrometry, were analysed according to distinct bear life stages (young: cub, yearling, subadult; mature: adult)...
December 12, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29222648/the-level-of-toxic-elements-in-edible-crops-from-seleniferous-area-punjab-india
#2
Margarita G Skalnaya, Sumit K Jaiswal, Ranjana Prakash, N Tejo Prakash, Andrei R Grabeklis, Irina V Zhegalova, Feng Zhang, Xiong Guo, Alexey A Tinkov, Anatoly V Skalny
The primary objective of the present study was to assess the level of selenium and toxic trace elements in wheat, rice, maize, and mustard from seleniferous areas of Punjab, India. The content of selenium (Se) and toxic trace elements, including aluminum (Al), arsenic (As), cadmium (Cd), mercury (Hg), nickel (Ni), lead (Pb), and tin (Sn), in crop samples was assessed using inductively coupled plasma mass-spectrometry after microwave digestion of the samples. The obtained data demonstrate that cultivation of crops on seleniferous soils significantly increased Se level in wheat, mustard, rice, and maize by a factor of more than 590, 111, 85, and 64, respectively...
December 8, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29218471/rural-environment-study-for-water-from-different-sources-in-cluster-of-villages-in-mehsana-district-of-gujarat
#3
Nitasha Khatri, Sanjiv Tyagi, Deepak Rawtani
Water pollution and water scarcity are major environmental issues in rural and urban areas. They lead to decline in the quality of water, especially drinking water. Proper qualitative assessment of water is thus necessary to ensure that the water consumed is potable. This study aims to analyze the physicochemical parameters in different sources of water in rural areas and assess the quality of water through a classification system based on BIS and CPCB standards. The classification method has defined water quality in six categories, viz...
December 7, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29214478/cigarette-butts-abundance-and-association-of-mercury-and-lead-along-the-persian-gulf-beach-an-initial-investigation
#4
Sina Dobaradaran, Torsten C Schmidt, Iraj Nabipour, Afshin Ostovar, Alireza Raeisi, Reza Saeedi, Maryam Khorsand, Nahid Khajeahmadi, Mozhgan Keshtkar
The toxic metal contents of cigarette butts and distribution of cigarette butts have not been studied well in maritime environment. In the present study, cigarette butts distribution and the associations of Hg and Pb from cigarette butts were monitored along the Persian Gulf with 10 days interval sampling time. The number of cigarette butts, and Hg and Pb associations of butts were found to vary widely between 2 and 38 items per square meter, 2.5 and 86.32 ng/g cigarette butt (CB), as well as 650 and 8630 ng/g CB, respectively...
December 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29206878/predictors-of-mercury-lead-cadmium-and-antimony-status-in-norwegian-never-pregnant-women-of-fertile-age
#5
Christina Herland Fløtre, Kristin Varsi, Thea Helm, Bjørn Bolann, Anne-Lise Bjørke-Monsen
BACKGROUND: The toxic trace elements mercury (Hg), lead (Pb), cadmium (Cd) and antimony (Sb) are transferred over the placenta to the fetus and secreted into the breastmilk. All four elements bioaccumulate in the body and as maternal age at delivery is increasing in industrialized countries, the burden of toxic trace elements in never-pregnant women of fertile age is of concern. METHODS: Healthy, never-pregnant women aged 18 to 40 years (n = 158) were recruited between June 2012 and March 2015 in Bergen, Norway...
2017: PloS One
https://www.readbyqxmd.com/read/29203196/hepatorenal-protective-effects-of-medicinal-herbs-in-an-gong-niu-huang-wan-agnh-against-cinnabar-and-realgar-induced-oxidative-stress-and-inflammatory-damage-in-mice
#6
Ao Li, Jing-Yao Zhang, Xiao Xiao, Songsong Wang, Jian-Bo Wan, Yu-Shuang Chai, Peng Li, Yitao Wang
An-Gong-Niu-Huang Wan (AGNH) is a famous traditional Chinese medicine prescription that contains cinnabar (HgS) and realgar (As2S2); the clinical practice of AGNH is hindered because both mercury and arsenic are hepatorenal toxic metalloids. It is noted that the cinnabar and realgar in AGNH are not used alone, but rather combined with different kinds of medicinal herbs as a formula to use. In this study, we evaluated the hepatorenal protective effects of the medicinal herbs in AGNH after co-exposure to cinnabar and realgar for 4 weeks in mice...
December 1, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29202293/sulfur-modified-rice-husk-biochar-a-green-method-for-the-remediation-of-mercury-contaminated-soil
#7
David O'Connor, Tianyue Peng, Guanghe Li, Shuxiao Wang, Lei Duan, Jan Mulder, Gerard Cornelissen, Zhenglin Cheng, Shengmao Yang, Deyi Hou
Mercury (Hg) contamination of surface soils has increased by ~86Giga grams due to anthropogenic activities. There is an urgent need to find new, effective and preferably 'green' remediation technologies to protect human health and the environment. Sulfur-modification of sorbents can greatly enhance Hg sorption capacity - by forming low solubility HgS (cinnabar). However, S-modified sorbents are not considered suitable for soil remediation due to the economic cost and secondary environmental impacts of sorbents such as granulated activated carbon (GAC), and the toxicity of S-modifiers such as thiol compounds...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29199152/low-level-hg2-exposure-modulates-the-b-cell-cytoskeletal-phosphoproteome
#8
Nicholas J Carruthers, Allen J Rosenspire, Joseph A Caruso, Paul M Stemmer
Exposure of Wehi-231 B-cells to Hg2+ for 5min resulted in concentration dependent changes in protein phosphorylations. Phosphorylation was quantified using mass spectrometry to analyze TiO2 and anti-pTyr antibody selected phosphopeptides from Wehi-231 digests. The most frequent and largest amplitude responses to Hg2+ exposure were increased phosphorylation although a decrease was observed for 1% of phosphoproteins detected in the untreated cells. A subset of proteins responded with an increase in phosphorylation to Hg2+ exposure at low micromolar concentrations...
November 30, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29199130/the-neurodevelopmental-toxicity-of-heavy-metals-a-fish-perspective
#9
Adrian J Green, Antonio Planchart
The causes of neurodegenerative diseases are complex with likely contributions from genetic susceptibility, and environmental exposures over an organism's lifetime. In this review, we examine the role that aquatic models, especially zebrafish, have played in the elucidation of mechanisms of heavy metal toxicity and nervous system function over the last half-decade. Focus is applied to cadmium, lead and mercury as significant contributors to central nervous system morbidity, and to the application of numerous transgenic zebrafish expressing fluorescent reporters within specific neuronal populations or brain regions enabling high-resolution neurodevelopmental and neurotoxicology research...
November 30, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29197524/mercuric-resistant-bacteria-aeromonas-exhibits-neurologic-toxic-effects-on-the-developmental-motor-reflexes-and-brain-oxidative-stress-in-mice-offspring
#10
Mohammad Ahmad
Mercury and its derivatives even in small concentration may cause a major human health problem. Though not reported in detail, there are various aquatic bacterial species that produce small quantities of methyl mercury (MM) growing under aerobic conditions. Consumption of food derived from sources contaminated with such bacteria within therapeutic doses and exposure to different forms of MM compounds through such sources may induce substantial toxic effects. In the present study, the perinatal oral exposure of pregnant mice to two strains of mercury resistant bacteria (MRB), Aeromonas KSU5 MRB and KSU6 MRB resulted in a significant reduction in postnatal body weight gain, delays in the opening of the eyes and appearance in the body hair fuzz, and deficits in the developing sensory motor reflexes in the mice pups during their weaning period on post-natal day (PD)7, PD14 and PD21...
November 29, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29190560/methylmercury-complexes-selection-of-thermodynamic-properties-and-application-to-the-modelling-of-a-column-experiment
#11
P Blanc, A Burnol, N Marty, J Hellal, V Guérin, V Laperche
Complexation with methyl groups produces the most toxic form of mercury, especially because of its capacity to bioconcentrate in living tissues. Understanding and integrating methylation and demethylation processes is of the utmost interest in providing geochemical models relevant for environmental assessment. In a first step, we investigated methylation at equilibrium, by selecting the thermodynamic properties of different complexes that form in the chemical system Hg-SO3-S-Cl-C-H2O. The selection included temperature dependencies of the equilibrium constants when available...
November 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29173465/the-chemical-speciation-spatial-distribution-and-toxicity-of-mercury-from-tibetan-medicine-zuotai%C3%AF-%C3%AE-hgs-and-hgcl2-in-mouse-kidney
#12
Cen Li, Wei Xu, Shengqi Chu, Zhiyuan Zheng, Yuancan Xiao, Linshuai Li, Hongtai Bi, Lixin Wei
Zuotai, a famous Tibetan medicinal mixture containing β-HgS, has been used to combine with herbal remedies for treating diseases for more than 1 300 years. The target organ for inorganic mercury toxicity is generally considered to be the kidney. Therefore, it is crucial to reveal the chemical speciation, spatial distribution and potential nephrotoxicity of mercury from Zuotai in kidney. To date, this remains poorly understood. We used X-ray absorption spectroscopy (XAS) and micro X-ray fluorescence (μ-XRF) imaging based on synchrotron radiation to study mercury chemical forms and mercury special distribution in kidney after mice were treated orally with Zuotai, β-HgS or HgCl2...
January 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29168740/dietary-intake-of-cadmium-lead-and-mercury-and-its-association-with-bone-health-in-healthy-premenopausal-women
#13
Jesus M Lavado-García, Luis M Puerto-Parejo, Raul Roncero-Martín, Jose M Moran, Juan D Pedrera-Zamorano, Ignacio J Aliaga, Olga Leal-Hernández, Maria L Canal-Macias
The bone is one of the relevant target organs of heavy metals, and heavy metal toxicity is associated with several degenerative processes, such osteoporosis and bone mineral alterations, that could lead to fractures. We aimed to study a presumed relationship between bone density, evaluated by quantitative bone ultrasound (QUS), dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) and the dietary intake of cadmium, lead and mercury in healthy premenopausal women. A total of 158 healthy, non-smoking, premenopausal women were incorporated into the study...
November 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29167424/mir-92a-and-mir-486-are-potential-diagnostic-biomarkers-for-mercury-poisoning-and-jointly-sustain-nf-%C3%AE%C2%BAb-activity-in-mercury-toxicity
#14
Enmin Ding, Jun Guo, Ying Bai, Hengdong Zhang, Xin Liu, Wenyan Cai, Lixin Zhong, Baoli Zhu
Occupational and environmental exposure to mercury is a public health concern worldwide. Although the altered epigenetic regulatory features, such as microRNA, have been associated with mercury exposure, the underlying molecular mechanism is not well illuminated. This study aimed to confirm that hsa-miR-92a and hsa-miR-486 are novel diagnostic biomarkers of occupational mercury poisoning, and to explore the underlying mechanism of miR-92a and miR-486 in mercury toxicity. RT-qPCR assays and receiver operating characteristics curve analyses were conducted to confirm the diagnostic value of miR-92a and miR-486 as biomarkers of occupational mercury poisoning...
November 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29164278/metals-and-organohalogen-contaminants-in-bald-eagles-haliaeetus-leucocephalus-from-ontario-1991-2008
#15
P A Martin, K D Hughes, G D Campbell, J L Shutt
We examined the degree of exposure of lead (Pb), mercury (Hg), and several organohalogen contaminants and its potential impact on survival of bald eagles in Ontario from 1991 to 2008. Overall, results for 43 dead or dying bald eagles collected in the province indicate that 23% (10/43) of birds died of Pb poisoning and 9% (4/43) died of suspected Hg poisoning. Pb poisoning was diagnosed based on exceedances of toxicity thresholds in liver and kidney and supported by clinical observations, necropsy results, and histology findings when available...
November 21, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29156266/seabirds-as-regional-biomonitors-of-legacy-toxicants-on-an-urbanized-coastline
#16
Corey A Clatterbuck, Rebecca L Lewison, Nathan G Dodder, Catherine Zeeman, Kenneth Schiff
Seabirds are often cited as sentinels of the marine environment, but are rarely used in traditional ocean and coastal contaminant monitoring. Four classes of persistent organic pollutants (POPs, n=68) and three trace elements (mercury, selenium, and arsenic) were measured in the eggs of California least terns (Sterna antillarum browni), caspian terns (Hydroprogne caspia), double-crested cormorants (Phalacrocorax auritus), and western gulls (Larus occidentalis) that nest in the Southern California Bight. Building on a periodic five year regional monitoring program, we measured contaminant exposure and assessed the utility of seabirds as regional contaminant biomonitors...
November 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29153031/human-co-culture-model-of-neurons-and-astrocytes-to-test-acute-cytotoxicity-of-neurotoxic-compounds
#17
Uliana De Simone, Francesca Caloni, Laura Gribaldo, Teresa Coccini
Alternative methods and their use in planning and conducting toxicology experiments have become essential for modern toxicologists, thus reducing or replacing living animals. Although in vitro human co-culture models allow the establishment of biologically relevant cell-cell interactions that recapitulate the tissue microenvironment and better mimic its physiology, the number of publications is limited specifically addressing this scientific area and utilizing this test method which could provide an additional valuable model in toxicological studies...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29150497/low-molecular-weight-thiols-and-thioredoxins-are-important-players-in-hg-ii-resistance-in-thermus-thermophilus-hb27
#18
J Norambuena, Y Wang, T Hanson, J M Boyd, T Barkay
Mercury (Hg), one of the most toxic and widely distributed heavy metals, has a high affinity for thiol groups. Thiol groups reduce and sequester Hg. Therefore, low molecular weight and protein thiols may be important cell components used in Hg resistance. To date, the role of low molecular weight thiols in Hg-detoxification remains understudied. The mercury resistance (mer) operon of Thermus thermophilus suggests an evolutionary link between Hg(II) resistance and low molecular weight thiol metabolism. This mer operon encodes for an enzyme involved in methionine biosynthesis, Oah...
November 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29150340/placental-transfer-and-levels-of-mercury-selenium-vitamin-e-and-docosahexaenoic-acid-in-maternal-and-umbilical-cord-blood
#19
Mineshi Sakamoto, Hing Man Chan, José L Domingo, Chihaya Koriyama, Katsuyuki Murata
Methylmercury (MeHg) is a neurotoxicant known to affect the developing fetal brain as a sensitive target organ. As most mercury (Hg) in blood is MeHg, total mercury (THg) levels in blood are used to estimate the body burden of MeHg. The nutrients selenium (Se), vitamin E, and docosahexaenoic acid (DHA) are protective against MeHg toxicity. We compared maternal and cord blood concentrations of biochemical substances, THg and Se, vitamin E, DHA, and other elements, fatty acids, and amino acids in 54 Japanese mother-newborn pairs to elucidate the fetal risk of MeHg toxicity...
November 14, 2017: Environment International
https://www.readbyqxmd.com/read/29146204/mercury-exposure-and-short-term-consequences-on-physiology-and-reproduction-in-antarctic-petrels
#20
Alice Carravieri, Jérôme Fort, Arnaud Tarroux, Yves Cherel, Oliver P Love, Solène Prieur, Maud Brault-Favrou, Paco Bustamante, Sébastien Descamps
Mercury (Hg) is a pervasive contaminant reaching Antarctic environments through atmospheric transport and deposition. Seabirds as meso to top predators can accumulate high quantities of Hg through diet. Reproduction is one of the most sensitive endpoints of Hg toxicity in marine birds. Yet, few studies have explored Hg exposure and effects in Antarctic seabirds, where increasing environmental perturbations challenge animal populations. This study focuses on the Antarctic petrel Thalassoica antarctica from Svarthamaren, Antarctica, where the world's largest breeding population is thought to be in decline...
November 13, 2017: Environmental Pollution
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