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Mercury toxicity

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https://www.readbyqxmd.com/read/28812058/environmental-pollutants-and-neurodevelopment-review-of-benefits-from-closure-of-a-coal-burning-power-plant-in-tongliang-china
#1
Vrinda Kalia, Frederica Perera, Deliang Tang
Background. Understanding preventable causes of neurodevelopmental disorders is a public health priority. Polycyclic aromatic hydrocarbons (PAH) from combustion of fossil fuel, lead, and mercury are among known neurodevelopmental toxicants. Method. For the first time, we comprehensively review the findings from a study by the Columbia Center for Children's Environmental Health and Chinese partners that followed 2 groups of mother-child pairs, one from 2002 and another from 2005, in Tongliang County, China. Pregnant mothers in the 2 cohorts experienced different exposure to PAH because a local coal-burning power plant was shut down in 2004...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28811865/oxidative-biochemistry-disbalance-and-changes-on-proteomic-profile-in-salivary-glands-of-rats-induced-by-chronic-exposure-to-methylmercury
#2
Leonardo Oliveira Bittencourt, Bruna Puty, Senda Charone, Walessa Alana Bragança Aragão, Paulo Mecenas Farias-Junior, Marcia Cristina Freitas Silva, Maria Elena Crespo-Lopez, Aline de Lima Leite, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima
Methylmercury (MeHg) is one of the most toxic mercury species, which can cause many systemic damages, but little is known about its effect in the salivary glands. This study aimed to analyze the mercury levels, oxidative stress, and proteomic profile in parotid, submandibular, and sublingual salivary glands of rats, after chronic MeHg intoxication. Two groups of twenty male Wistar rats (90 days of age) were used on the experiment. MeHg group was intoxicated by intragastric gavage with MeHg at a dose of 0.04 mg/kg/day for 60 days, while the control group received only oil...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28808314/cellular-toxicity-pathways-of-inorganic-and-methyl-mercury-in-the-green-microalga-chlamydomonas-reinhardtii
#3
Rebecca Beauvais-Flück, Vera I Slaveykova, Claudia Cosio
Contamination by mercury (Hg) is a worldwide concern because of Hg toxicity and biomagnification in aquatic food webs. Nevertheless, bioavailability and cellular toxicity pathways of inorganic (IHg) and methyl-Hg (MeHg) remain poorly understood. We analyzed the uptake, transcriptomic, and physiological responses in the microalga Chlamydomonas reinhardtii exposed to IHg or MeHg. Bioavailability of MeHg was up to 27× higher than for IHg. Genes involved in cell processes, energy metabolism and transport were dysregulated by both Hg species...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797960/acute-toxic-effects-of-zinc-and-mercury-on-survival-standard-metabolism-and-metal-accumulation-in-juvenile-ridgetail-white-prawn-exopalaemon-carinicauda
#4
Chengsong Zhang, Kuijie Yu, Fuhua Li, Jianhai Xiang
Ridgetail white prawn (Exopalaemon carinicauda) is widely distributed in Chinese coastal zones, especially in the Yellow Sea and Bohai Sea. It is not only considered as an important economic species in China, but also taken as a potential indicator species for the environmental pollution in the estuaries. At present, the responses of this species to environmental toxicants, including trace metal are not well understood. In this study, the acute toxic effects of zinc (Zn) and mercury (Hg) on the survival, oxygen consumption, ammonia-N excretion, and metal accumulation were investigated in the juveniles of E...
August 7, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28795724/chronic-exposure-to-inorganic-mercury-induces-biochemical-and-morphological-changes-in-the-salivary-glands-of-rats
#5
W A B Aragão, N M M da Costa, N C F Fagundes, M C F Silva, S M Alves-Junior, J J V Pinheiro, L L Amado, M E Crespo-López, C S F Maia, R R Lima
Mercury exposure is considered to be a public health problem due to the generation of toxic effects on human health as a result of environmental and occupational conditions. The inorganic form of mercury (HgCl2) can cause several biological changes in cells and tissues through its cumulative toxic potential, but little has been experimentally proven about the effects of inorganic mercury on salivary glands, an important modulator organ of oral health. This study analyzes the effects of prolonged low dose exposure to HgCl2 on the salivary glands of rats...
August 10, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28792083/mercury-contamination-in-bats-from-the-central-united-states
#6
Jennifer M Korstian, Matthew M Chumchal, Victoria J Bennett, Amanda M Hale
Mercury (Hg) is a highly toxic metal that has detrimental effects on wildlife. We surveyed Hg concentrations in 10 species of bats collected at wind farms in the central United States and found contamination in all species. Mercury concentration in fur was highly variable both within and between species (range 1.08-10.52 μg/g). Despite the distance between sites (up to 1200 km), only 2 of the 5 species sampled at multiple locations had fur Hg concentrations that differed between sites. Mercury concentrations observed in the present study all fell within the previously reported ranges for bats collected from the northeastern United States and Canada, although many of the bats we sampled had lower maximum Hg concentrations...
August 9, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28783303/single-walled-carbon-nanotube-reactor-for-redox-transformation-of-mercury-dichloride
#7
Yuliya V Fedoseeva, Andrey S Orekhov, Galina N Chekhova, Victor O Koroteev, Mikhail A Kanygin, Boris V Senkovskiy, Andrey Chuvilin, Daniele Pontiroli, Mauro Riccò, Lyubov G Bulusheva, Alexander V Okotrub
Single-walled carbon nanotubes (SWCNTs) possessing a confined inner space protected by chemically resistant shells are promising for delivery, storage, and desorption of various compounds, as well as carrying out specific reactions. Here, we show that SWCNTs interact with molten mercury dichloride (HgCl2) and guide its transformation into dimercury dichloride (Hg2Cl2) in the cavity. The chemical state of host SWCNTs remains almost unchanged except for a small p-doping from the guest Hg2Cl2 nanocrystals. The density functional theory calculations reveal that the encapsulated HgCl2 molecules become negatively charged and start interacting via chlorine bridges when local concentration increases...
August 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28763123/laying-waste-to-mercury-inexpensive-sorbents-made-from-sulfur-and-recycled-cooking-oils
#8
Max Worthington, Renata Kucera, Ines Albuquerque, Christopher Gibson, Alexander Sibley, Ashley Slattery, Jonathan Campbell, Salah Alboaiji, Katherine Muller, Jason Young, Nick Adamson, Jason Gascooke, Deshetti Jampaiah, Ylias Sabri, Suresh Bhargava, Samuel Ippolito, David Lewis, Jamie Quinton, Amanda Ellis, Alexander Johs, Gonçalo Bernardes, Justin M Chalker
Mercury pollution threatens the environment and human health across the globe. This neurotoxic substance is encountered in artisanal gold mining, coal combustion, oil and gas refining, waste incineration, chloralkalai plant operation, metallurgy, and areas of agriculture in which mercury-rich fungicides are used. Thousands of tonnes of mercury are emitted annually through these activities. With the Minamata Convention on Mercury entering force this year, increasing regulation of mercury pollution is imminent...
August 1, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28761418/the-interaction-of-genetics-and-environmental-toxicants-in-amyotrophic-lateral-sclerosis-results-from-animal-models
#9
REVIEW
Roger B Sher
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that results in the progressive death of motor neurons, leading to paralysis and eventual death. There is presently no cure for ALS, and only two drugs are available, neither of which provide significant extension of life. The wide variation in onset and progression of the disease, both in sporadic and even in strongly penetrant monogenic familial forms of ALS, indicate that in addition to background genetic variation impacting the disease process, environmental exposures are likely contributors...
June 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28759766/metal-toxicity-assessment-by-sentinel-species-of-mangroves-in-situ-case-study-integrating-chemical-and-biomarkers-analyses
#10
Luis Felipe de Almeida Duarte, Caroline Araújo de Souza, Camilo Dias Seabra Pereira, Marcelo Antonio Amaro Pinheiro
Globally, there is a lack of knowledge about tropical ecotoxicology dealing with the potential impact of metal contamination in mangrove ecosystem. This habitat is considered a nursery for several animal species, among them the "uçá"-crab (Ucides cordatus), known as a key species due to its biological and economical importance. This study evaluated the association involving metal contamination (Cd, Cu, Pb, Cr, Mn and Hg) in water, sediment, red-mangrove vegetation (Rhizophora mangle) and tissues of uçá crab, together with its geno-cytotoxic responses, based on micronucleated hemocytes frequency and the retention time of neutral red in lysosomes...
July 28, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28757588/complexation-based-detection-of-nickel-ii-at-a-graphene-chelate-probe-in-the-presence-of-cobalt-and-zinc-by-adsorptive-stripping-voltammetry
#11
Keagan Pokpas, Nazeem Jahed, Priscilla G Baker, Emmanuel I Iwuoha
The adsorptive stripping voltammetric detection of nickel and cobalt in water samples at metal film electrodes has been extensively studied. In this work, a novel, environmentally friendly, metal-free electrochemical probe was constructed for the ultra-trace determination of Ni(2+) in water samples by Adsorptive Cathodic Stripping Voltammetry (AdCSV). The electrochemical platform is based on the adsorptive accumulation of Ni(2+) ions directly onto a glassy carbon electrode (GCE) modified with dimethylglyoxime (DMG) as chelating agent and a Nafion-graphene (NGr) nanocomposite to enhance electrode sensitivity...
July 25, 2017: Sensors
https://www.readbyqxmd.com/read/28755925/a-flow-imaging-microscopy-based-method-using-mass-to-volume-ratio-to-derive-the-porosity-of-plga-microparticles
#12
A S Sediq, S K D Waasdorp, M R Nejadnik, M M C van Beers, J Meulenaar, R Verrijk, W Jiskoot
The release of drugs from poly(lactic-co-glycolic acid) (PLGA) microparticles depends to a large extent on the porosity of the particles. Therefore, porosity determination of PLGA microparticles is extremely important during pharmaceutical product development. Currently, mercury intrusion porosimetry (MIP) is widely used despite its disadvantages, such as the need for a large amount of sample (several hundreds of milligrams) and residual toxic waste. Here, we present a method based on estimation of the volume of a known mass (a few milligrams) of particles using Micro-Flow Imaging (MFI) to determine microparticle batch porosity...
July 26, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28742846/endophytic-fungal-communities-of-polygonum-acuminatum-and-aeschynomene-fluminensis-are-influenced-by-soil-mercury-contamination
#13
William Pietro-Souza, Ivani Souza Mello, Suzana Junges Vendruscullo, Gilvan Ferreira da Silva, Cátia Nunes da Cunha, James Francis White, Marcos Antônio Soares
The endophytic fungal communities of Polygonum acuminatum and Aeschynomene fluminensis were examined with respect to soil mercury (Hg) contamination. Plants were collected in places with and without Hg+2 for isolation and identification of their endophytic root fungi. We evaluated frequency of colonization, number of isolates and richness, indices of diversity and similarity, functional traits (hydrolytic enzymes, siderophores, indoleacetic acid, antibiosis and metal tolerance) and growth promotion of Aeschynomene fluminensis inoculated with endophytic fungi on soil with mercury...
2017: PloS One
https://www.readbyqxmd.com/read/28737720/a-simple-and-highly-sensitive-thymine-sensor-for-mercury-ion-detection-based-on-surface-enhanced-raman-spectroscopy-and-the-mechanism-study
#14
Hao Yang, Sui-Bo Ye, Yu Fu, Weihong Zhang, Fangyan Xie, Li Gong, Ping-Ping Fang, Jian Chen, Yexiang Tong
Mercury ion (Hg(2+)) is recognized as one of the most toxic metal ions for the environment and for human health. Techniques utilized in the detection of Hg(2+) are an important factor. Herein, a simple thymine was successfully employed as the surface enhanced Raman spectroscopy sensor for Hg(2+) ion detection. The limit of detection (LOD) of the developed sensor is better than 0.1 nM (0.02 ppb). This sensor can also selectively distinguish Hg(2+) ions over 7 types of alkali, heavy metal and transition-metal ions...
July 24, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28737385/a-synthetic-circuit-for-mercury-bioremediation-using-self-assembling-functional-amyloids
#15
Pei Kun R Tay, Peter Q Nguyen, Neel S Joshi
Synthetic biology approaches to bioremediation are a key sustainable strategy to leverage the self-replicating and programmable aspects of biology for environmental stewardship. The increasing spread of anthropogenic mercury pollution into our habitats and food chains is a pressing concern. Here, we explore the use of programmed bacterial biofilms to aid in the sequestration of mercury. We demonstrate that by integrating a mercury-responsive promoter and an operon encoding a mercury-absorbing self-assembling extracellular protein nanofiber, we can engineer bacteria that can detect and sequester toxic Hg(2+) ions from the environment...
August 2, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28733900/the-putative-role-of-environmental-mercury-in-the-pathogenesis-and-pathophysiology-of-autism-spectrum-disorders-and-subtypes
#16
REVIEW
G Morris, B K Puri, R E Frye, M Maes
Exposure to organic forms of mercury has the theoretical capacity to generate a range of immune abnormalities coupled with chronic nitro-oxidative stress seen in children with autism spectrum disorder (ASD). The paper discusses possible mechanisms explaining the neurotoxic effects of mercury and possible associations between mercury exposure and ASD subtypes. Environmental mercury is neurotoxic at doses well below the current reference levels considered to be safe, with evidence of neurotoxicity in children exposed to environmental sources including fish consumption and ethylmercury-containing vaccines...
July 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28731302/lead-ii-binding-in-metallothioneins
#17
Daisy L Wong, Maureen E Merrifield-MacRae, Martin J Stillman
Heavy metal exposure has long been associated with metallothionein (MT) regulation and its functions. MT is a ubiquitous, cysteine-rich protein that is involved in homeostatic metal response for the essential metals zinc and copper, as well as detoxification of heavy metals; the most commonly proposed being cadmium. MT binds in vivo to a number of metals in addition to zinc, cadmium and copper, such as bismuth. In vitro, metallation with a wide range of metals (especially mercury, arsenic, and lead) has been reported using a variety of analytical methods...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28728354/spatial-assessment-of-potential-ecological-risk-of-soil-heavy-metals-from-informal-e-waste-recycling-in-ghana
#18
Vincent Nartey Kyere, Klaus Greve, Sampson Atiemo, James Hawkins Ephraim
The rapidly increasing annual global volumes and the inherently valuable fractions of e-waste have created an avenue for individuals in Agbogbloshie, Accra, Ghana to make a living by utilizing unconventional, uncontrolled, primitive and crude procedures to recycle and recover valuable metals from these wastes. The current form of recycling procedures releases hazardous fractions such as heavy metals into the soils posing a significant risk to ecology and human health. 132 soil samples based on 100 m grid intervals were collected using handheld GPS and analyzed for Cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), lead (Pb) and zinc (Zn) heavy metals...
July 10, 2017: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/28728113/catalase-based-hydrogen-peroxide-biosensor-for-mercury-determination-by-inhibition-measurements
#19
Basant Elsebai, Mariana Emilia Ghica, Mohammed Nooredeen Abbas, Christopher M A Brett
A new amperometric hydrogen peroxide enzyme inhibition biosensor for the indirect determination of toxic mercury ions, Hg(2+), based on catalase immobilized on a glassy carbon electrode surface by cross-linking with glutaraldehyde and bovine serum albumin, is reported. The parameters influencing biosensor performance were optimized, including enzyme loading, the amount of hydrogen peroxide, the applied potential and electrolyte pH. It was shown that the inhibition of catalase by Hg(2+) species is irreversible, with a linear inhibition response between 5×10(-11) and 5×10(-10)M...
July 11, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28718096/contamination-status-of-arsenic-in-fish-and-shellfish-from-three-river-basins-in-ghana
#20
Francis Gbogbo, Samuel Darlynton Otoo, Obed Asomaning, Robert Quaye Huago
Fish and shellfish are regularly consumed and sold in Ghana, yet studies on arsenic pollution in Ghana are limited largely to ground water. This study evaluated arsenic concentrations in seven species of shellfish and 10 species of fish inhabiting the mouth of Ankobra, Densu and Volta basins in Ghana and assessed the public health implications. Arsenic levels varied from 0.2 to 2.2 mg L(-1) in the three rivers and were higher than WHO recommended values of 10 μg L(-1) for drinking water. Except for Periophthalmus sp...
August 2017: Environmental Monitoring and Assessment
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