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Mercury poisoning

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https://www.readbyqxmd.com/read/29145289/mercury-poisoning-through-intravenous-administration-two-case-reports-with-literature-review
#1
Qiuying Lu, Zilong Liu, Xiaorui Chen
RATIONALE: Metallic mercury poisoning through intravenous injection is rare, especially for a homicide attempt. Diagnosis and treatment of the disease are challenging. PATIENT CONCERNS: A 34-year-old male presented with pyrexia, chill, fatigue, body aches, and pain of the dorsal aspect of right foot. Another case is that of a 29-year-old male who committed suicide by injecting himself metallic mercury 15 g intravenously and presented with dizzy, dyspnea, fatigue, sweatiness, and waist soreness...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29124976/rethinking-mercury-the-role-of-selenium-in-the-pathophysiology-of-mercury-toxicity
#2
Henry A Spiller
INTRODUCTION: There is increasing evidence that the pathophysiological target of mercury is in fact selenium, rather than the covalent binding of mercury to sulfur in the body's ubiquitous sulfhydryl groups. The role of selenium in mercury poisoning is multifaceted, bidirectional, and central to understanding the target organ toxicity of mercury. METHODS: An initial search was performed using Medline/PubMed, Toxline, Google Scholar, and Google for published work on mercury and selenium...
November 10, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29093364/mercury-poisoning-in-a-fisherman-working-on-a-pelagic-fishing-vessel-due-to-excessive-tuna-consumption
#3
Ji-Sung Ahn, Kyung Wook Kang, Won-Yang Kang, Hyeong-Min Lim, Seunghyeon Cho, Jai-Dong Moon, Won-Ju Park
OBJECTIVE: To report the case of a fisherman who developed chronic mercury poisoning due to excessive consumption of tuna while working on a pelagic fishing vessel. CASE REPORT: A 48-year-old male deep-sea fisherman developed paresthesia and pain in both legs while working at sea. He continued working for over 4 months on a pelagic fishing vessel but was eventually unable to function normally as his condition deteriorated. Upon arrival on land, he received specialist treatment, including imaging studies, for 2 months; however, the cause of the symptoms was not identified...
November 1, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29081130/-change-in-peripheral-nervous-conduction-velocity-in-patients-with-occupational-chronic-mercury-poisoning-and-related-influencing-factors
#4
L Li, B Jiang, J Lai, W R Dai, X Li, W F Liu, Z X Yang, L Xie
Objective: To investigate the change in peripheral nervous conduction velocity in patients with occupational chronic mercury poisoning and related influencing factors. Methods: From February 2011 to December 2014, urinary mercury examination and neural electromyography were performed for 104 patients with occupational chronic mercury poisoning. The data on age, type of work, working years of mercury exposure, and past medical history were collected, and peripheral nervous conduction velocity and its correlation with age, working years of mercury exposure, and urinary mercury concentration were analyzed...
August 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29063135/metal-chelators-and-neurotoxicity-lead-mercury-and-arsenic
#5
REVIEW
Geir Bjørklund, Joachim Mutter, Jan Aaseth
This article reviews the clinical use of the metal chelators sodium 2,3-dimercapto-1-propanesulfonate (DMPS), meso-2,3-dimercaptosuccinic acid (DMSA), and calcium disodium edetate (CaEDTA, calcium EDTA) in overexposure and poisonings with salts of lead (Pb), mercury (Hg), and arsenic (As). DMSA has considerably lower toxicity than the classic heavy metal antagonist BAL (2,3-dimercaptopropanol) and is also less toxic than DMPS. Because of its adverse effects, CaEDTA should be replaced by DMSA as the antidote of choice in treating moderate Pb poisoning...
October 24, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29062186/lead-poisoning-due-to-herbal-medications
#6
Prashant Sakharkar
Many herbal products are harmless or possess minimal toxicity, whereas, some contain toxic ingredients that may not be identified due to lack of quality control or not listed on the label. Over the years, several case reports and studies have documented that herbal medications may contain ingredients that are toxic. Several studies have documented that some herbal medications contained high concentrations of heavy metals, such as lead, mercury, and arsenic. Publications of such case reports and studies have repeatedly reminded us that we have failed in our legal and civic duties of educating users of herbal medications and general population about the grave concerns posed by the herbal medications and their associated toxicities...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29033890/an-enigmatic-case-of-acute-mercury-poisoning-clinical-immunological-findings-and-platelet-function
#7
Ilka Kleffner, Susann Eichler, Tobias Ruck, Lisa Schüngel, Steffen Pfeuffer, Philipp Polzer, Ralf Dittrich, Rainer Dziewas, Catharina C Gross, Kerstin Göbel, Heinz Wiendl, Beate E Kehrel, Sven G Meuth
Severe mercury intoxication is very rare in developed countries, but still occurs as the result of volatile substance abuse, suicide attempts, occupational hazards, or endemic food ingestion as reported in the cases of public health disasters in Iraq and in Minamata Bay, Japan. Here, we describe the dramatic physical and cognitive decline of a 23-year-old patient caused by a severe methyl mercury (MeHg) intoxication of unknown origin. We show serial magnetic resonance imaging (MRI) of the patient's brain, as well as ex vivo analyses of blood and cerebrospinal fluid including multicolor flow cytometric measurements, functional assays of hemostaseologic efficacy, and evaluation of regulatory effector molecules...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28965577/effects-of-biological-factors-and-health-condition-on-mercury-and-selenium-concentrations-in-the-cartilage-meniscus-and-anterior-cruciate-ligament
#8
Danuta I Kosik-Bogacka, Natalia Lanocha-Arendarczyk, Karolina Kot, Zaneta Ciosek, Pawel Zietek, Maciej Karaczun, Bogumila Pilarczyk, Agnieszka Tomza-Marciniak, Joanna Podlasinska, Elzbieta Kalisinska, Joanna Pyzia
Due the long-term nature of joint tissue remodeling processes, knee structures including meniscus and anterior cruciate ligament (ACL) can be a model for studying the bioaccumulation of mercury (Hg) and selenium (Se). The accumulation and retention of Hg in human tissues can have a negative effect on the proper functioning of homeostasis-affecting organisms. A factor of chronic poisoning with Hg forms is probably the Se:Hg ratio in tissues. Se:Hg molar ratios below one may increase Hg toxicity potentials, while molar ratios that approach or exceed one effectively may protect against Hg toxicity...
December 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28936834/-advances-of-toxicity-evaluation-of-cinnabar-and-compatibility-necessity-analysis
#9
REVIEW
Tong Ding, Jiao-Yang Luo, Xu Han, Shi-Hai Yang, Rui-Chao Lin, Mei-Hua Yang
Cinnabars are widely used in the clinic and shows unique efficacy, and it has been used in treating diseases for thousands of years either single-use or combination with other traditional Chinese medicines. Cinnabar mainly contains mercury, which displays obvious hepatotoxicity and nephrotoxicity. The safety of cinnabar and its rational use caused extensive attention. However, there are some misunderstanding that cinnabar shows equivalent toxicity to the toxicity of mercury compounds such as mercuric chloride and methylmercury in safety evaluation of cinnabar, which in our view exaggerates the toxicity...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28889271/neurotoxicity-of-metal-mixtures
#10
V M Andrade, M Aschner, A P Marreilha Dos Santos
Metals are the oldest toxins known to humans. Metals differ from other toxic substances in that they are neither created nor destroyed by humans (Casarett and Doull's, Toxicology: the basic science of poisons, 8th edn. McGraw-Hill, London, 2013). Metals are of great importance in our daily life and their frequent use makes their omnipresence and a constant source of human exposure. Metals such as arsenic [As], lead [Pb], mercury [Hg], aluminum [Al] and cadmium [Cd] do not have any specific role in an organism and can be toxic even at low levels...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28889263/chemical-speciation-of-selenium-and-mercury-as-determinant-of-their-neurotoxicity
#11
C S Oliveira, B C Piccoli, M Aschner, J B T Rocha
The antagonism of mercury toxicity by selenium has been well documented. Mercury is a toxic metal, widespread in the environment. The main target organs (kidneys, lungs, or brain) of mercury vary depending on its chemical forms (inorganic or organic). Selenium is a semimetal essential to mammalian life as part of the amino acid selenocysteine, which is required to the synthesis of the selenoproteins. This chapter has the aim of disclosing the role of selenide or hydrogen selenide (Se(-2) or HSe(-)) as central metabolite of selenium and as an important antidote of the electrophilic mercury forms (particularly, Hg(2+) and MeHg)...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28858755/calls-to-florida-poison-control-centers-about-mercury-trends-over-2003-2013
#12
Matthew O Gribble, Aniruddha Deshpande, Wendy B Stephan, Candis M Hunter, Richard S Weisman
OBJECTIVE: The aim of this analysis was to contrast trends in exposure-report calls and informational queries (a measure of public interest) about mercury to the Florida Poison Control Centers over 2003-2013. MATERIALS AND METHODS: Poison-control specialists coded calls to Florida Poison Control Centers by substance of concern, caller demographics, and whether the call pertained to an exposure event or was an informational query. For the present study, call records regarding mercury were de-identified and provided along with daily total number of calls for statistical analysis...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28844937/dimercapto-1-propanesulfonic-acid-dmps-induces-metaphase-ii-mouse-oocyte-deterioration
#13
Sarah R Aldhaheri, Roohi Jeelani, Hamid-Reza Kohan-Ghadr, Sana N Khan, Sasha Mikhael, Christina Washington, Robert T Morris, Husam M Abu-Soud
In light of the recent lead contamination of the water in Flint, Michigan and its potential adverse outcomes, much research and media attention has turned towards the safety profile of commonly used chelators. Dimercapto-1-propanesulfonic acid (DMPS) typically used in the treatment of lead, mercury and arsenic poisoning also displays a high affinity towards transition metals such as zinc and copper, essential for biological functioning. It is given in series of dosages (0.2-0.4g/day) over a long period, and has the ability to enter cells...
August 24, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28701428/a-mercury-toxicity-case-complicated-by-hyponatremia-and-abnormal-endocrinological-test-results
#14
Matthew Carter, Abdul Abdi, Fareeha Naz, Farouq Thabet, Arpita Vyas
Mercury (Hg) poisoning is considered a rare disease by the National Institutes of Health and the diagnosis can present great challenges to clinicians. Children who are exposed to Hg can present with a wide variety of symptoms, including acrodynia, tremor, excessive salivation, and psychiatric symptoms, including insomnia. However, endocrinologic manifestations from Hg exposure are less well known. This is a case report of a 12-year-old boy who presented with body rash, irritability, insomnia, and profuse sweating after returning from a summer camp...
August 2017: Pediatrics
https://www.readbyqxmd.com/read/28666216/assessment-of-28-trace-elements-and-17-amino-acid-levels-in-muscular-tissues-of-broiler-chicken-gallus-gallus-suffering-from-arsenic-trioxide
#15
Si-Wen Li, Ying He, Hong-Jing Zhao, Yu Wang, Juan-Juan Liu, Yi-Zhi Shao, Jing-Lun Li, Xiao Sun, Li-Na Zhang, Ming-Wei Xing
The contents of 28 trace elements, 17 amino acid were evaluated in muscular tissues (wings, crureus and pectoralis) of chickens in response to arsenic trioxide (As2O3). A total of 200 one-day-old male Hy-line chickens were fed either a commercial diet (C-group) or an As2O3 supplement diet containing 7.5mg/kg (L-group), 15mg/kg (M-group) or 30mg/kg (H-group) As2O3 for 90 days. The elements content was analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Under As2O3 exposure, the concentration of As were elevated 8...
June 27, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28649389/cases-of-acute-mercury-poisoning-by-mercury-vapor-exposure-during-the-demolition-of-a-fluorescent-lamp-factory
#16
Sang Yoon Do, Chul Gab Lee, Jae Yoon Kim, Young Hoon Moon, Min Sung Kim, In Ho Bae, Han Soo Song
BACKGROUND: In 2015, workers dismantling a fluorescent lamp factory in Korea were affected by mercury poisoning from exposure to mercury vapor. CASE PRESENTATION: Eighteen out of the 21 workers who participated in the demolition project presented with symptoms of poisoning and, of these, 10 had persistent symptoms even at 18 months after the initial exposure to mercury vapor. Early symptoms of 18 workers included a general skin rash, pruritus, myalgia, sleep disturbance, and cough and sputum production...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28643849/prevalence-of-exposure-of-heavy-metals-and-their-impact-on-health-consequences
#17
Kanwal Rehman, Fiza Fatima, Iqra Waheed, Muhammad Sajid Hamid Akash
Even in the current era of growing technology, the concentration of heavy metals present in drinking water is still not within the recommended limits as set by the regulatory authorities in different countries of the world. Drinking water contaminated with heavy metals namely; arsenic, cadmium, nickel, mercury, chromium, zinc, and lead is becoming a major health concern for public and health care professionals. Occupational exposure to heavy metals is known to occur by the utilization of these metals in various industrial processes and/or contents including color pigments and alloys...
June 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28612926/the-use-of-silver-amalgam-for-treatment-of-shell-ulcerations-in-turtles-60-cases
#18
F Spadola, M Morici
Shell ulcers were diagnosed based on clinical appearance in 60 turtles. Under general anaesthesia, surgical curettage was performed using a burr mounted on a micro-grinder. A calcium hydroxide paste was applied to the debrided lesions before the application of restorative material. Lesions were completely filled with rapidly hardening silver amalgam. Treated terrapins were hospitalised in dry containers and later were housed in tanks with controlled temperature 24 hours. Fillings were found spontaneously expulsed at various periods after placement...
June 14, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28594236/the-blood-of-my-veins-mercury-minamata-and-the-soul-of-japan
#19
Gerald F O'Malley
The methylmercury contamination of Minamata Bay during the WWII postwar period resulted in thousands of Japanese citizens suffering horrific neurological injury. Fear and miscommunication destroyed and changed family and social structure. In addition, the Minamata poisoning caused momentous changes in the civic discourse in Japan and was an instrumental event in the democratization of the country. This manuscript describes the effects that the environmental contamination and human poising had in the transition of Japan from a feudal society to a democratic one...
September 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28578479/vulnerability-associated-with-symptoms-similar-to-those-of-mercury-poisoning-in-communities-from-xingu-river-amazon-basin
#20
Flávio Mnaoel Rodrigues Da Silva-Junior, Ritta M Oleinski, Antonia E S Azevedo, Kátia C M C Monroe, Marina Dos Santos, Tatiane Britto Da Silveira, Adrianne Maria Netto De Oliveira, Maria Cristina Flores Soares, Tatiana Da Silva Pereira
The Brazilian Amazon is known to be a region with high levels of mercury (Hg) in the environment and studies point to an association between high levels of natural mercury in the mother rock and the vast number of clandestine gold mines. Other studies already report the contamination of fish in this region, as well as high levels of Hg in biological material from environmentally exposed populations. On the other hand, this is one of the least developed regions of the planet and it is necessary to understand the vulnerability factors in these populations that may be intoxicated by this element...
June 3, 2017: Environmental Geochemistry and Health
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