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Brian Waters, Kenji Hara, Natsuki Ikematsu, Mio Takayama, Aya Matsusue, Masayuki Kashiwagi, Shin-Ichi Kubo
A female in her late teens purposely ingested alcohol fuel containing methanol to commit suicide, which she admitted on social media. She was found in distress by her parents and died at the hospital some hours later. Autopsy revealed swelling of the brain and edematous and congestive lungs. No other trauma or unusual findings were revealed at autopsy. Methanol was detected upon routine screening for alcohols by headspace gas chromatography with flame-ionization detection. To confirm the presence of methanol and its metabolite formic acid, a method with detection by mass spectrometry was used...
June 4, 2018: Forensic Science International
Hong Zheng, Feng Qiu, Hui Zhao, Jie Chen, Lei Wang, Haiyan Zou
A specific, sensitive and rapid ultra high performance liquid chromatography-tandem mass spectrometric (UHPLC-MS/MS) method was developed and validated for simultaneous determination of six major bioactive constituents in Rhizoma Panacis Japonici (RPJ), including oleanolic acid-type chikusetsusaponin V, IV, hemsgiganoside B, damarane-type ginsenoside Rb1, Rg1 and Re in rat plasma, using estazolam as the internal standard (IS). Plasma samples were pretreated with methanol/acetonitrile (1:1, V/V) for protein precipitation...
June 7, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Krzysztof Kamil Wojtanowski, Tomasz Mroczek
The high performance liquid chromatography (HPLC) coupled to electrospray ionization (ESI) octopole orthogonal acceleration time-of-flight (TOF) mass spectrometry (MS) was developed to separate secondary metabolites belonging to different groups of compounds with a wide range of polarity, i.e. phenolic acids, flavonoids, sesquiterpenes and others present in minute amounts, in a single run. Moreover, application of ESI-TOF-MS with a simple in source type of fragmentation and high mass accuracy measurements (around 2 ppm) in both positive and negative ionization modes with different and optimized fragmentor voltages, enabled the identification of each single compound based on proposed fragmentation patterns...
October 31, 2018: Analytica Chimica Acta
Virginia Mazzini, Guangming Liu, Vincent S J Craig
We present an experimental investigation of specific-ion effects in non-aqueous solvents, with the aim of elucidating the role of the solvent in perturbing the fundamental ion-specific trend. The focus is on the anions: CH3 COO- >F- >Cl- >Br- >I- >ClO4 - >SCN- in the solvents water, methanol, formamide, dimethyl sulfoxide (DMSO), and propylene carbonate (PC). Two types of experiments are presented. The first experiment employs the technique of size exclusion chromatography to evaluate the elution times of electrolytes in the different solvents...
June 14, 2018: Journal of Chemical Physics
Li Wencheng, Kichul Cho, Yasuhiro Yamasaki, Satoshi Takeshita, Kiju Hwang, Daekyung Kim, Tatsuya Oda
The dinoflagellate Heterocapsa circularisquama is highly toxic to bivalves. However, significant toxicity to finfish species has not been reported. We previously found that H. circularisquama has light-dependent haemolytic agents. Purification and chemical structural analyses revealed that the haemolytic agent H2-a is a porphyrin derivative, which exhibits light-dependent cytotoxicity toward tumour cells. To clarify the biological activity of H2-a further, its antibacterial activities against Gram-positive and Gram-negative bacteria were investigated in this study...
June 7, 2018: Aquatic Toxicology
Stephan Niedermeier, Iza Matarashvili, Bezhan Chankvetadze, Gerhard K E Scriba
A high-performance liquid chromatography method for the determination of dextromepromazine, levomepromazine sulfoxide and 2-methoxyphenothiazine in levomepromazine samples was developed. The separation of the analytes was achieved within 10 min on a stationary phase containing cellulose tris(4-methylbenzoate) as chiral selector. The mobile phase consisted of 0.1% diethylamine in methanol with a flow rate of 1.0 mL/min. The method was validated according to the International Council for Harmonization guideline Q2(R1)...
June 8, 2018: Journal of Pharmaceutical and Biomedical Analysis
Sheng Chu, Pengfei Ou, Pegah Ghamari, Srinivas Vanka, Baowen Zhou, Ishiang Shih, Jun Song, Zetian Mi
Photoelectrochemical (PEC) reduction of CO2 with H2 O not only provides an opportunity for reducing net CO2 emissions but also produces value-added chemical feedstocks and fuels. Syngas, a mixture of CO and H2 , is a key feedstock for the production of methanol and other commodity hydrocarbons in industry. However, it is challenging to achieve efficient and stable PEC CO2 reduction into syngas with controlled composition owing to the difficulties associated with the chemical inertness of CO2 and complex reaction network of CO2 conversion...
June 15, 2018: Journal of the American Chemical Society
Yifan Lang, Kaihong Li, Wei Meng, Renrong Liu
OBJECTIVE: To develop an indirect competitive chemiluminescent enzyme immunoassay( CLEIA) for the detection of bisphenol A in milk samples. METHODS: The CLEIA conditions including antigen coated concentration, concentration of methanol, concentration of enzyme labeled anti-antibody, p H and ionic strength were optimized to build competitive inhibition curve, determine the linear range and detection limit, and study the recovery of spiked milk samples. RESULTS: In the standard curve of the optimized CLEIA, the half maximal inhibitory concentration( IC_(50)) was 3...
March 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
Feng Han, Ning Kang, Yongqing Chen, Yiwen Dong, Siyu Zhang
OBJECTIVE: To assess the occupational health risk of pure methanol fuel( M100) during the methanol fuel pilot stage. METHODS: The subjects are workers who are exposed to M100 in pilot areas for methanol vehicles, southwest of China. Use field investigation and detection to get the information of production technology, exposure level of methanol and prevention measures and facilities. Use Singapore Occupational Exposure to Harmful Chemicals Semi-Quantitative Method to assess the health risk of the methanol...
March 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
Bin Wang, Yumin Niu, Jing Zhang, Bing Shao, Min Zhang
OBJECTIVE: To establish a rapid and sensitive method for the analysis of eight bisphenols in breast milk using small amount of samples. METHODS: Breast milk samples were extracted by acetonitrile and the lipid substances were removed by freezing under-20 ℃ condition. Then the samples were derivatized with dansyl chloride and analyzed by ultra-performance liquid chromatography-tandem mass spectrometry( UPLCMS/MS). The seperation was performed on an ACQUITY UPLC BEH Phenyl column( 2...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Haimin Zou, Chen Zhou, Chengjun Sun, Xiaosong Yang, Jun Wen, Yongxin Li, Hongyan Zeng
OBJECTIVE: To develop a simple and sensitive high performance liquid chromatographic method for simultaneous determination of catechin hydrate, epicatechin, epigallocatechin, epicatechin gallate, epigallocatechin gallate, dihydromyricetin, glycyrrhizic acid and glycyrrhetinic acid in healthy food for anti-hangover and hepatoprotection, and compare with the capillary electrophoresis method established by our laboratory. METHODS: The samples were ultrasonically extracted by using methanol-water( 4∶ 1, V/V) for 30 minutes and then centrifuged at 10 000 r/min for 10 minutes...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Parvaneh Mehrbod, Muna Ali Abdalla, Fatemeh Fotouhi, Masoumeh Heidarzadeh, Abimbola O Aro, Jacobus N Eloff, Lyndy J McGaw, Folorunso O Fasina
BACKGROUND: Influenza infection is a major public health threat. The role of influenza A virus-induced inflammatory response in severe cases of this disease is widely recognized. Drug resistance and side effects of chemical treatments have been observed, resulting in increased interest in alternative use of herbal medications for prophylaxis against this infection. The South African medicinal plant, Rapanea melanophloeos (RM) (L.) Mez of the family Myrsinaceae was selected owing to its traditional use for the treatment of several diseases such as respiratory ailments and also previous preliminary studies of anti-influenza activity of its methanolic extract...
June 15, 2018: BMC Complementary and Alternative Medicine
Dilnur Tursun, Jiang He, Marhaba Hairulla, Bo Cheng, Wei-Jun Yang, Dilnur Aliaji
This study aimed to develop an HPLC method for simultaneous determination of the 3 components in Ziziphora bungeana. The optimum HPLC condition was as follows:ZORBAX SB-C₁₈ column(4.6 mm×250 mm, 5.0 μm)with gradient elution of methanol (A)-0.2% glacial acetic acid (B), detection wavelength 340 nm,column temperature 30 °C, flow rate 1 mL·min⁻¹. There were good linearity between peak areas and injection quantity of caffeic acid, rosmarinic acid, and linarin in the range of 2-40 mg·L⁻¹( r =0...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Xiao-Yu Chen, Jian-Xin Han, Yu-Shuang Liu, Aisa Hajiakber, Tao Yuan
Seven aromatic glycosides (1-7), including four phenylethanol glycosides, one phenylmethanol glycoside, one phenylpropane glycoside and one benzoside, were isolated from the methanolic extract of Uighur Medicine Elaeagnus angustifolia flowers. Their structures were elucidated based on the analysis of spectroscopic data (1D, 2D NMR and HR-MS). Compound 1 is a new compound, named as angustifol A. Six known compounds were identified as 2-phenylethyl-O-β-D-glucopyranoside(2), salidroside (3), vanillic acid 4-O-β-D-glucopyranoside(4), vanilloloside (5), (Z)-isoconiferin (6), 2-phenylethyl-6-O-α-L-arabinofuranosyl-β-D-glucopyranoside (7)...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Ho Soo Lim, Ju Young Hwang, EunA Choi, Gunyoung Lee, Sang Soon Yun, MeeKyung Kim
An improved and highly sensitive method was developed and validated for the determination of 12 (seven permitted and five non-permitted in Korea) non-nutritive sweeteners in various foods using liquid chromatography-electrospray ionisation-tandem mass spectrometry. The chromatographic separation was performed on an Xbridge BEH C18 column (3 mm × 100 mm, 2.5 μm) with gradient elution using 10 mM ammonium acetate in water and 10 mM ammonium acetate in methanol. Sample preparation consisted of simple dilution, homogenisation, centrifugation and purification with a C18 cartridge prior to analysis...
June 14, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Hadir M Maher, Nourah Z Alzoman, Shereen M Shehata, Norah O Abanmy
Dasatinib (DAS) is a tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia and in the management of ulcerative colitis (UC). Since some nutraceuticals (e.g. curcumin, olive oil, and cocoa extract) could alter the function of ABC transporters and /or CYP450 enzymes, DAS bioavailability could potentially be affected following their co-administration. This work aims at studying the possibility of PK interaction between DAS and the selected nutraceuticals in UC rats using UPLC- MS/MS...
2018: PloS One
Aderonke Ajibola Adeyemo, Abhijith Shettar, Imtiyaz Ahmad Bhat, Paturu Kondaiah, Partha Sarathi Mukherjee
Coordination-driven self-assembly of organometallic η6-arene ruthenium(ii) supramolecular architectures (MA1-MA4) was carried out by employing dinuclear ruthenium acceptors [Ru2(μ-η4-C2O4)(CH3OH)2(η6-p-cymene)2](CF3SO3)2 (Rua), [Ru2(μ-η4-C6H2O4)(CH3OH)2(η6-p-cymene)2](CF3SO3)2 (Rub), [Ru2(dhnq)(H2O)2(η6-p-cymene)2](CF3SO3)2 (Ruc) and [Ru2(dhtq)(H2O)2(η6-p-cymene)2](CF3SO3)2 (Rud) separately with a new tetratopic donor (TD) in methanol at room temperature [TD = N,N,N',N'-tetra(pyridin-4-yl)-[1,1'-biphenyl]-4,4'-diamine]...
June 14, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Hiroyuki Iguchi, Yusuke Yoshida, Kento Fujisawa, Hiroki Taga, Hiroya Yurimoto, Tokitaka Oyama, Yasuyoshi Sakai
KaiC protein is the pivotal component of the circadian clock in cyanobacteria. While KaiC family proteins are well conserved throughout divergent phylogenetic lineages, studies of the physiological roles of KaiC proteins from other microorganisms have been limited. We examined the role of the KaiC proteins, KaiC1 and KaiC2, in the methanol-utilizing bacterium Methylobacterium extorquens AM1. Wild-type M. extorquens AM1 cells exhibited temperature-dependent UV resistance (TDR) under permissive growth temperatures (24-32°C)...
June 14, 2018: Environmental Microbiology Reports
Qasem Abdallah, Ibrahim Al-Deeb, Ammar Bader, Fayez Hamam, Kamel Saleh, Amin Abdulmajid
Angiogenesis plays a crucial role in malignant tumor progression and development. The present study aimed to identify lead plants with selective anti-angiogenic properties. A total of 26 methanolic extracts obtained from 18 plants growing in Saudi Arabia and Jordan that belong to the Lamiaceae family were screened for their cytotoxic and anti-angiogenic activities using MTT and rat aortic ring assays, respectively. Four novel extracts of Thymbra capitata (L.) Cav., Phlomis viscosa Poir, Salvia samuelssonii Rech...
June 12, 2018: Molecular Medicine Reports
Arunkumar Naik Bukke, Fathima Nazneen Hadi, K Suresh Babu, P Chandramati Shankar
This article contains data on in vitro cytotoxicity activity of chloroform, methanolic and water extracts of leaf and heartwood of Caesalpinia sappan L. a medicinal plant against Breast cancer (MCF-7) and Lung cancer (A-549) cells. This data shows that Brazilin A, a natural bioactive compound in heartwood of Caesalpinia sappan L. induced cell death in breast cancer (MCF-7) cells. The therapeutic property was further proved by docking the Brazilin A molecule against BCL-2 protein (an apoptotic inhibitor) using auto dock tools...
August 2018: Data in Brief
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