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https://www.readbyqxmd.com/read/28732286/development-of-liquid-chromatographic-methods-for-enantioseparation-and-sensitive-detection-of-%C3%AE-adrenolytics-%C3%AE-2-agonists-in-human-plasma-using-a-single-enantiomer-reagent
#1
Poonam Malik, Ravi Bhushan
Enantioseparation of four commonly used β-adrenolytics (bisoprolol, salbutamol, and carvedilol, marketed as racemic mixtures) has been achieved by both TLC and RPHPLC via an indirect approach. A new chiral reagent, (S)-naproxen benzotriazole ester, was synthesized and it was characterized by UV, IR, (1)HNMR, elemental analysis and polarimetry. It was used to synthesize diastereomeric derivatives of the three β-adrenolytics under microwave irradiation. TLC separation of diastereomeric derivatives was achieved which were then isolated by preparative approach; these were characterized and were used as standard reference for determining absolute configuration of diastereomeric derivatives and for establishing validated HPLC method for enantioseparation and sensitive detection of the three β-adrenolytics in human plasma...
July 14, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28731710/computational-calorimetry-of-pnipam-cononsolvency-in-water-methanol-mixtures
#2
Cahit Dalgicdir, Francisco Rodriguez-Ropero, Nico F A van der Vegt
We revisit the mechanism for cononsolvency of PNIPAM in water/methanol mixtures. Using extensive molecular dynamics simulations we calculate the calorimetric enthalpy of the PNIPAM collapse transition and observe a unique fingerprint of PNIPAM cononsolvency which is analysed in terms of microscopic interactions. We find that polymer hydration is the determining factor for PNIPAM collapse in the cononsolvency regime. In particular, it is shown that methanol frustrates the ability of water to form hydrogen bonds with the amide proton and therefore causes polymer collapse...
July 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28731312/gentiana-kurroo-royle-attenuates-the-metabolic-aberrations-in-diabetic-rats-swertiamarin-swertisin-and-lupeol-being-the-possible-bioactive-principles
#3
Khalid Ghazanfar, Khan Mubashir, Showkat A Dar, Tazeen Nazir, Iqra Hameed, Bashir A Ganai, Seema Akbar, Akbar Masood
Background Gentiana kuroo Royle is a medicinally important plant of north-western Himalayas used for various ailments. In the present study, the plant extracts were investigated for the antidiabetic effects in streptozotocin-induced diabetic rats. Methods The impact of the extracts on serum glucose levels of diabetic rats was compared with reference drug - glibenclamide-treated diabetic rats. Streptozotocin injection was used to induce diabetes in fasted rats. Various biochemical, physiological and histopathological parameters in diabetic rats were observed for assessing the antidiabetic activity...
April 29, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28731093/rapid-and-selective-synthesis-of-spiropyrazolines-and-pyrazolylphthalides-employing-seyferth-gilbert-reagent
#4
Ashis Kumar Gupta, Narendra Kumar Vaishanv, Ruchir Kant, Kishor Mohanan
An unexpected product-selectivity in the reaction of 2-arylideneindane-1,3-dione with dimethyl diazomethylphosphonate leading to the formation of two different types of products is reported. The reaction carried out in acetone in the presence of catalytic amount of cesium fluoride afforded spiropyrazoline phosphonates via 1,3-dipolar cycloaddition reaction, whereas the reaction in methanol yielded an interesting class of pyrazolylphthalides. This strategy provides an efficient alternative method for the construction of pyrazolylphthalides, and moreover, the process is general, works under mild conditions, and exhibits high functional group compatibility...
July 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28730555/intermittent-versus-continuous-renal-replacement-therapy-in-acute-methanol-poisoning-comparison-of-clinical-effectiveness-in-mass-poisoning-outbreaks
#5
Sergey Zakharov, Jan Rulisek, Olga Nurieva, Katerina Kotikova, Tomas Navratil, Martin Komarc, Daniela Pelclova, Knut Erik Hovda
BACKGROUND: Intermittent hemodialysis (IHD) is the modality of choice in the extracorporeal treatment (ECTR) of acute methanol poisoning. However, the comparative clinical effectiveness of intermittent versus continuous modalities (CRRT) is unknown. During an outbreak of mass methanol poisoning, we therefore studied the effect of IHD versus CRRT on mortality and the prevalence of visual/central nervous system (CNS) sequelae in survivors. METHODS: The study was designed as prospective observational cohort study...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28729923/correlation-analysis-of-the-rates-of-solvolysis-of-4-bromopiperidine-a-reaction-following-a-grob-fragmentation-pathway
#6
Dennis Neil Kevill, Zoon Ha Ryu, Malcolm John D'Souza
A Grunwald-Winstein treatment of the specific rates of solvolysis of 4-bromopiperidine gives for aqueous ethanol, methanol, acetone, and dioxane a very good logarithmic correlation against the YBr solvent ionizing power values with a slope (m value) of 0.46±0.02, consistent with the operation of a synchronous Grob fragmentation mechanism. When the organic component of the solvent is 2,2,2-trifluoroethanol (TFE), the data points show a negative deviation, consistent with an appreciable deactivating interaction of the acidic TFE component of the solvent with the lone-pair of electrons present on the nitrogen...
June 2017: European Journal of Chemistry
https://www.readbyqxmd.com/read/28728931/new-anthracenyl-polar-embedded-stationary-phases-with-enhanced-aromatic-selectivity-a-combined-experimental-and-theoretical-study-part-1-experimental-study
#7
Mélanie Mignot, Clément De Saint Jores, Alain Tchapla, François Boyer, Pascal Cardinael, Valérie Peulon-Agasse
New polar embedded aromatic stationary phases of different functionalities (mono- and trifunctional) and on different silica supports (Fully Porous Particle (FPP) and Superficially Porous Particle (SPP)) were synthesized to determine the impact of the functionality on the retention process and the selectivity towards aromatic compounds. A full experimental characterization was performed using a combination of techniques (elemental analysis, thermogravimetric measurements, infrared spectroscopy and solid-state NMR) to differentiate unambiguously the mono- and trifunctional Stationary Phases (SP)...
June 27, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28727413/quantifying-the-metabolome-of-pseudomonas-taiwanensis-vlb120-evaluation-of-hot-and-cold-combined-quenching-extraction-approaches
#8
Gossa Garedew Wordofa, Mette Kristensen, Lars Schrübbers, Douglas McCloskey, Jochen Forster, Konstantin Schneider
Absolute quantification of free intracellular metabolites is a valuable tool in both, pathway discovery and metabolic engineering. In this study, we conducted a comprehensive examination of different hot and cold combined quenching/extraction approaches to extract and quantify intracellular metabolites of Pseudomonas taiwanensis VLB120 to provide a useful reference dataset of absolute intracellular metabolite concentrations. The suitability of commonly used metabolomics tools including pressure driven fast filtration system followed by combined quenching/extraction techniques (such as cold methanol/acetonitrile/water, hot water, boiling ethanol/water, as well as cold ethanol/water) were tested and evaluated for P...
July 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28726702/photodegradation-of-the-benzothiostrobin-in-solution-and-on-soil-and-glass-surface
#9
Zihao Zhou, Yu Yang, Zhangyu Zheng, Minghua Wang
The photolytic characteristics of benzothiostrobin were investigated in solution and on soil and glass surface. The main influence factors such as initial concentration, organic solvent and the aqueous environmental substances, including NO2(-), NO3(-), Fe(2+), Fe(3+), H2O2 and turbidity were investigated. Three photodegradation products of benzothiostrobin were identified by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The photodegradation rates of benzothiostrobin increased with decreasing initial concentration of benzothiostrobin...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28726405/fluorescence-enhancement-of-unconstrained-gfp-chromophore-analogues-based-on-the-push-pull-substituent-effect
#10
Meng-Shiue Tsai, Chun-Lin Ou, Chi-Jui Tsai, Yen-Chin Huang, Yuan-Chung Cheng, Shih-Sheng Sun, Jye-Shane Yang
Unlike the high fluorescence quantum yield of the naturally occurring green fluorescence protein (GFP, Φf ∼ 0.8), the GFP chromophore, a benzylidenedimethylimidazolinone (BDI) dye, is nearly nonfluorescent (Φf < 0.001) in common solutions at room temperature. While many efforts have been devoted into the BDI chromophore engineering for fluorescence recovery, limited success has been achieved for structurally unconstrained GFP chromophore analogues (uGFPc). Herein we report a rational design of uGFPc toward an unprecedentedly high fluorescence quantum efficiency of 0...
July 20, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28726396/the-potent-anti-inflammatory-and-anti-adipogenic-properties-of-bamboo-sasa-coreana-nakai-leaves-extract-and-its-major-constituent-flavonoids
#11
Ji Hye Yang, Moon-Hee Choi, Seung Hwa Yang, Sam Seok Cho, Su Jung Park, Hyun-Jae Shin, Sung Hwan Ki
The pro-inflammatory response and recruitment of macrophages into adipose tissue contribute to metabolic dysfunction. Here, we reported the anti-inflammatory and anti-adipogenic effects of the methanol (MeOH) extract and ethylacetate (EtOAc) fraction of bamboo leaf and its molecular mechanism in RAW264.7 cells and 3T3-L1 adipocytes, respectively. Functional macrophage migration assays also were performed. Surprisingly, EtOAc fraction of MeOH extracts from native Korean plant species Sasa coreana Nakai (SCN) has shown potent anti-inflammatory properties; SCN pretreatment inhibited nitric oxide (NO) production (p<0...
July 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28726376/dentritic-cuptpd-catalyst-for-enhanced-electrochemical-oxidation-of-methanol
#12
Xiaoqin Shi, Ying Wen, Xiaoyu Guo, Yuxia Pan, Yuanyuan Ji, Ye Ying, Hai-Feng Yang
The CuPtPd catalyst is designed and synthesized successfully via directly reducing metal ions. The composition, morphology and structure of the as-prepared CuPtPd nanohybrids are characterized by scanning electron microscope (SEM) and transmission electron microscopy (TEM), energy-dispersive spectrometer (EDS), selected-area electron diffraction (SAED), X-ray diffraction (XRD), and inductively coupled plasma atomic emission spectrometry (ICP-AES). By comparison of the electrocatalytic properties of the ternary CuPtPd catalyst with bimetallic catalysts, we find that ternary nanocomposites perform better electrocatalytic and anti-poisoning activity towards oxidation of methanol...
July 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28725626/evaluation-of-anticancer-activity-of-cordia-dichotoma-leaves-against-a-human-prostate-carcinoma-cell-line-pc3
#13
Md Azizur Rahman, Sahabjada, Juber Akhtar
Mechanisms of antioxidant and apoptosis induction may be involved in the management of cancer by medicinal plants. Aim of the study was designed to evaluate anticancer activity of the methanolic extract of Cordia dichotoma leaves (MECD) against a human prostate carcinoma cell line, PC3. Flavonoid content was determined by colorimetric principle and antioxidant activity by various in vitro assays. MTT, DCFH-DA and DAPI staining assays were performed for the evaluation of cytotoxicity, analysis of induction of apoptosis and intracellular reactive oxygen species (ROS) activity level by MECD against human prostate carcinoma cell line, PC3...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28725623/isolation-and-characterization-of-antimicrobial-compound-from-the-stem-bark-of-the-traditionally-used-medicinal-plant-adenium-obesum
#14
Mohammed Sohail Akhtar, Mohammad Amzad Hossain, Sadri Abdullah Said
BACKGROUND: Medicinal plants constitute a natural reservoir for medicines worldwide. They serve mainstream therapeutics and are central in folklore medicine. In case of Adenium obesum (Lav, Apocynaceae), indigenous people of Oman use it for the treatment of venereal diseases, wounds, skin diseases, headaches, muscle pain as well as joint pain; yet, the active ingredients have not been classified. To screened the antioxidant and antimicrobial activities of an identified compound that we isolated from the highest active chloroform extract...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28725622/authentication-of-piper-betle-l-folium-and-quantification-of-their-antifungal-activity
#15
I Made Agus Gelgel Wirasuta, I Gusti Ayu Made Srinadi, Ida Bagus Gede Dwidasmara, Ni Luh Putu Putri Ardiyanti, I Gusti Ayu Arya Trisnadewi, Ni Luh Putu Vidya Paramita
The TLC profiles of intra- and inter-day precision for Piper betle L. (PBL) folium methanol extract was studied for their peak marker recognition and identification. The Numerical chromatographic parameters (NCPs) of the peak markers, the hierarchical clustering analysis (HCA) and the principal component analysis (PCA) were applied to authenticate the PBL. folium extract from other Piper species folium extract and to ensure the antifungal activity quality of the PBL essential oil. The spotted extract was developed with the mobile phase of toluene: ethyl acetate; 93:7, (v/v)...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28725620/attenuation-of-diabetic-nephropathy-in-streptozotocin-induced-diabetic-rats-by-punica-granatum-linn-leaves-extract
#16
Snehal Nitin Mestry, Jayesh Bachu Dhodi, Sangita Balbhim Kumbhar, Archana Ramesh Juvekar
With an objective to develop Complementary and Alternative Medicine for the treatment of diabetic nephropathy, the present study investigated the protective effects of methanolic extract of Punica granatum leaves (MPGL) in streptozotocin-induced diabetic nephropathy. Diabetic nephropathy has become a leading cause of end stage renal failure worldwide. P. granatum, due to its anti-diabetic, anti-inflammatory and antioxidant activities may retard the progression of diabetic nephropathy. In this study, diabetes was induced by a single injection of streptozotocin (STZ, 45 mg/kg, i...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28725141/high-performance-thin-layer-chromatography-based-concurrent-estimation-of-biomarkers-ent-phyllanthidine-and-rutin-in-the-dried-aerial-parts-of-flueggea-virosa
#17
Nasir A Siddiqui, Ramzi A Mothana, Adnan J Al-Rehaily, Perwez Alam, Muhammad Yousaf, Sarfaraz Ahmed, Abdulrahman Alatar
The biomarkers are needed to be defined for standardization purposes so that safe and effective herbal formulations can be catered to the society. There is an urgent need for statistical support of herbal drugs because most of the herbal products are still used in the non-standardized form. This study is based on the development of a simple and sensitive RP-HPTLC method for concurrent estimation of two biomarkers ent-phyllanthidine and rutin in the methanol extract of aerial parts of Flueggea virosa. The developed method was found to be simple, economic and sensitive...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28725000/trivalent-y-3-ionic-sensor-development-based-on-e-methyl-n-nitrobenzylidene-benzenesulfonohydrazide-mnbbsh-derivatives-modified-with-nafion-matrix
#18
Mohammad Musarraf Hussain, Mohammed M Rahman, Muhammad Nadeem Arshad, Abdullah M Asiri
(E)-Methyl-N'-nitrobenzylidene-benzenesulfonohydrazide (MNBBSH) compounds were synthesized using a condensation procedure from the derivatives of nitrobenzaldehyde and 4-Methyl-benzenesulfonylhydrazine, which crystallized in ethanol and methanol as well as characterized by FTIR, UV-Vis, (1)H-NMR, and (13)C-NMR. MNBBSH structure was confirmed using a single crystal X-ray diffraction technique and used for the detection of selective yttrium ion (Y(3+)) by I-V system. A thin layer of MNBBSH was deposited onto a glassy carbon electrode (GCE) with 5% nafion for the sensitive and selective Y(3+) sensor...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724901/real-time-and-label-free-chemical-sensor-on-a-chip-using-monolithic-si-on-batio3-mid-infrared-waveguides
#19
Tiening Jin, Leigang Li, Bruce Zhang, Hao-Yu Greg Lin, Haiyan Wang, Pao Tai Lin
Chip-scale chemical detection is demonstrated by using mid-Infrared (mid-IR) photonic circuits consisting of amorphous silicon (a-Si) waveguides on an epitaxial barium titanate (BaTiO3, BTO) thin film. The highly c-axis oriented BTO film was grown by the pulsed laser deposition (PLD) method and it exhibits a broad transparent window from λ = 2.5 μm up to 7 μm. The waveguide structure was fabricated by the complementary metal-oxide-semiconductor (CMOS) process and a sharp fundamental waveguide mode has been observed...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724204/gait-and-balance-impairment-after-acute-methanol-poisoning
#20
Kamila Peterová, Hana Brožová, Jiří Klempíř, Irena Lišková, Ondřej Bezdíček, Petr Ridzoň, Manuela Vaněčková, Sergej Zakharov, Daniela Pelclová, Michal Miovský, Evžen Růžička
Neurological sequelae including gait impairment were reported in survivors after methanol intoxication; however, no systematic study has been published so far. We aimed to analyse gait and balance impairment in a group of Czech methanol poisoning survivors. We examined 43 patients (age 46±13 years) 2-8 months after methanol poisoning and 43 healthy controls. Investigations contained a shortened version of Falls Efficacy Scale (FES), clinical tests of gait and balance including Timed Up and Go test (TUG) and gait analysis using GaitRite(®) system, neurological and neuropsychological examination, brain imaging, EMG and tests of alcohol consumption...
July 19, 2017: Basic & Clinical Pharmacology & Toxicology
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