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https://www.readbyqxmd.com/read/28741646/aggressiveness-in-depression-a-neglected-symptom-possibly-associated-with-bipolarity-and-mixed-features
#1
N Verdolini, G Perugi, L Samalin, A Murru, J Angst, J-M Azorin, C L Bowden, S Mosolov, A H Young, M Barbuti, G Guiso, D Popovic, E Vieta, I Pacchiarotti
OBJECTIVE: To evaluate aggressiveness during a major depressive episode (MDE) and its relationship with bipolar disorder (BD) in a post hoc analysis of the BRIDGE-II-MIX study. METHOD: A total of 2811 individuals were enrolled in this multicenter cross-sectional study. MDE patients with (MDE-A, n = 399) and without aggressiveness (MDE-N, n = 2412) were compared through chi-square test or Student's t-test. A stepwise backward logistic regression model was performed...
July 25, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28691250/obesity-in-patients-with-major-depression-is-related-to-bipolarity-and-mixed-features-evidence-from-the-bridge-ii-mix-study
#2
Eleonora Petri, Olivia Bacci, Margherita Barbuti, Isabella Pacchiarotti, Jean-Michel Azorin, Jules Angst, Charles L Bowden, Sergey Mosolov, Eduard Vieta, Allan H Young, Giulio Perugi
OBJECTIVES: The Bipolar Disorders: Improving Diagnosis, Guidance and Education (BRIDGE)-II-Mix study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions. The present post-hoc analysis evaluated the association between obesity and the presence of mixed features and bipolarity. METHODS: A total of 2811 MDE subjects were enrolled in a multicenter cross-sectional study. In 2744 patients, the body mass index (BMI) was evaluated...
July 10, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28684747/mir-320a-as-a-potential-novel-circulating-biomarker-of-arrhythmogenic-cardiomyopathy
#3
Elena Sommariva, Yuri D'Alessandra, Floriana Maria Farina, Michela Casella, Fabio Cattaneo, Valentina Catto, Mattia Chiesa, Ilaria Stadiotti, Silvia Brambilla, Antonio Dello Russo, Corrado Carbucicchio, Giulia Vettor, Daniela Riggio, Maria Teresa Sandri, Andrea Barbuti, Gianluca Vernillo, Manuela Muratori, Matteo Dal Ferro, Gianfranco Sinagra, Silvia Moimas, Mauro Giacca, Gualtiero Ivanoe Colombo, Giulio Pompilio, Claudio Tondo
Diagnosis of Arrhythmogenic CardioMyopathy (ACM) is challenging and often late after disease onset. No circulating biomarkers are available to date. Given their involvement in several cardiovascular diseases, plasma microRNAs warranted investigation as potential non-invasive diagnostic tools in ACM. We sought to identify circulating microRNAs differentially expressed in ACM with respect to Healthy Controls (HC) and Idiopathic Ventricular Tachycardia patients (IVT), often in differential diagnosis. ACM and HC subjects were screened for plasmatic expression of 377 microRNAs and validation was performed in 36 ACM, 53 HC, 21 IVT...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28641149/thyroid-autoimmunity-in-bipolar-disorder-a-systematic-review
#4
REVIEW
Margherita Barbuti, André F Carvalho, Cristiano A Köhler, Andrea Murru, Norma Verdolini, Giovanni Guiso, Ludovic Samalin, Michael Maes, Brendon Stubbs, Giulio Perugi, Eduard Vieta, Isabella Pacchiarotti
BACKGROUND: Accumulating evidence points to the pathophysiological relevance between immune dysfunction and mood disorders. High rates of thyroid dysfunction have been found in patients with bipolar disorder (BD), compared to the general population. A systematic review of the relationship between BD and thyroid autoimmunity was performed. METHODS: Pubmed, EMBASE and PsycINFO databases were searched up till January 28th, 2017. This review has been conducted according to the PRISMA statements...
October 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28558366/antidepressant-induced-hypomania-mania-in-patients-with-major-depression-evidence-from-the-bridge-ii-mix-study
#5
Margherita Barbuti, Isabella Pacchiarotti, Eduard Vieta, Jean-Michel Azorin, Jules Angst, Charles L Bowden, Sergey Mosolov, Allan H Young, Giulio Perugi
BACKGROUND: The issue of antidepressant-induced mood switches to hypomania, mania, or mixed states within the course of mayor depressive disorder (MDD) has been a controversial topic. The present post-hoc analysis of the BRIDGE-II-MIX study focuses on the clinical features of patients with history of antidepressant-induced hypomania/mania (AIHM) in a large international sample of patients with major depressive episode (MDE). METHODS: 2811 subjects with major depression were enrolled in this multicentre cross-sectional study...
May 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28538682/enteric-viruses-and-fecal-bacteria-indicators-to-assess-groundwater-quality-and-suitability-for-irrigation
#6
Osvalda De Giglio, Giuseppina Caggiano, Francesco Bagordo, Giovanna Barbuti, Silvia Brigida, Federica Lugoli, Tiziana Grassi, Giuseppina La Rosa, Luca Lucentini, Vito Felice Uricchio, Antonella De Donno, Maria Teresa Montagna
According to Italian Ministerial Decree No. 185 of 12 June 2003, water is considered suitable for irrigation if levels of fecal bacteria (i.e., Escherichia coli and Salmonella) are within certain parameters. The detection of other microorganisms is not required. The aim of this study is to determine the bacteriological quality of groundwater used for irrigation and the occurrence of enteric viruses (Norovirus, Enterovirus, Rotavirus, Hepatovirus A), and to compare the presence of viruses with the fecal bacteria indicators...
May 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28248852/serosurveillance-of-hepatitis-a-in-a-region-which-adopted-the-universal-mass-vaccination
#7
Maria Filomena Gallone, Francesco Desiante, Maria Serena Gallone, Giovanna Barbuti, Silvio Tafuri, Cinzia Germinario
Hepatitis A is a common infectious disease worldwide that was endemic in many regions of Southern Italy, such as Apulia region. After a large hepatitis A outbreak occurred between 1996 and 1997, in Apulia an active-free immunization program that was targeted to new-borns and adolescents was started. The aim of this study is to investigate the hepatitis A seroprevalence in the adult Apulian population 18 years after the immunization program introduction, in order to evaluate the risk of new epidemics onset.The study was carried out from May 2011 to June 2012 among blood donors from Department of Transfusion Medicine and Blood Bank of Policlinico General Hospital in Bari...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28182231/a-gain-of-function-mutation-in-the-cardiac-pacemaker-hcn4-channel-increasing-camp-sensitivity-is-associated-with-familial-inappropriate-sinus-tachycardia
#8
Mirko Baruscotti, Annalisa Bucchi, Raffaella Milanesi, Manuel Paina, Andrea Barbuti, Tomaso Gnecchi-Ruscone, Elisabetta Bianco, Laura Vitali-Serdoz, Riccardo Cappato, Dario DiFrancesco
No abstract text is available yet for this article.
January 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28131876/modulating-the-function-of-atp-binding-cassette-subfamily-g-member-2-abcg2-with-inhibitor-cabozantinib
#9
Guan-Nan Zhang, Yun-Kai Zhang, Yi-Jun Wang, Anna Maria Barbuti, Xi-Jun Zhu, Xin-Yue Yu, Ai-Wen Wen, John N D Wurpel, Zhe-Sheng Chen
Cabozantinib (XL184) is a small molecule tyrosine kinase receptor inhibitor, which targets c-Met and VEGFR2. Cabozantinib has been approved by the Food and Drug Administration to treat advanced medullary thyroid cancer and renal cell carcinoma. In the present study, we evaluated the ability of cabozantinib to modulate the function of the ATP-binding cassette subfamily G member 2 (ABCG2) by sensitizing cells that are resistant to ABCG2 substrate antineoplastic drugs. We used a drug-selected resistant cell line H460/MX20 and three ABCG2 stable transfected cell lines ABCG2-482-R2, ABCG2-482-G2, and ABCG2-482-T7, which overexpress ABCG2...
May 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27918948/adult-autism-subthreshold-spectrum-adas-spectrum-validation-of-a-questionnaire-investigating-subthreshold-autism-spectrum
#10
L Dell'Osso, C Gesi, E Massimetti, I M Cremone, M Barbuti, G Maccariello, I Moroni, S Barlati, G Castellini, M Luciano, L Bossini, M Rocchetti, M Signorelli, E Aguglia, A Fagiolini, P Politi, V Ricca, A Vita, C Carmassi, M Maj
AIM: Increasing literature has shown the usefulness of a dimensional approach to autism. The present study aimed to determine the psychometric properties of the Adult Autism Subthreshold Spectrum (AdAS Spectrum), a new questionnaire specifically tailored to assess subthreshold forms of autism spectrum disorder (ASD) in adulthood. METHODS: 102 adults endorsing at least one DSM-5 symptom criterion for ASD (ASDc), 143 adults diagnosed with a feeding and eating disorder (FED), and 160 subjects with no mental disorders (CTL), were recruited from 7 Italian University Departments of Psychiatry and administered the following: SCID-5, Autism-Spectrum Quotient (AQ), Ritvo Autism and Asperger Diagnostic Scale 14-item version (RAADS-14), and AdAS Spectrum...
February 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27800441/study-on-potential-clostridium-botulinum-growth-and-toxin-production-in-parma-ham
#11
Giuseppe Merialdi, Mattia Ramini, Giovanni Parolari, Silvana Barbuti, Maria Angela Frustoli, Roberta Taddei, Stefano Pongolini, Paolo Ardigò, Paolo Cozzolino
The objective of this study was to investigate Clostridium botulinum growth and toxin production in the industrially manufactured Italian Parma ham. The study focuses on the Parma ham production phase identified as maximum risk to C. botulinum proliferation, i.e. the transition from cold phase (salting and resting) to a phase carried out at temperature between 15 and 23°C (drying). A preliminary in vitro test was carried out in order to verify the capability of 6 C. botulinum strains (1 type A, 4 type B, and 1 type E strains) to grow in conditions of temperature, pH and NaCl concentration comparable to those of the beginning stage of ham drying...
April 19, 2016: Italian Journal of Food Safety
https://www.readbyqxmd.com/read/27783346/microbiological-and-hydrogeological-assessment-of-groundwater-in-southern-italy
#12
Osvalda De Giglio, Giovanna Barbuti, Paolo Trerotoli, Silvia Brigida, Angelantonio Calabrese, Giuseppe Di Vittorio, Grazia Lovero, Giuseppina Caggiano, Vito Felice Uricchio, Maria Teresa Montagna
This study represents the first investigation of microbiological groundwater pollution as a function of aquifer type and season for the Apulia region of southern Italy. Two hundred and seven wells were randomly selected from those monitored by the Regional Agency for Environmental Protection for emergency use. Both compulsory (Escherichia coli, Total Coliform, and Enterococci) and optional (Pseudomonas aeruginosa, Salmonella spp., Heterotrophic Plate Count at 37 and 22 °C) microbiological parameters were assessed regularly at these wells...
November 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27599668/human-derived-cardiomyocytes-a-decade-of-knowledge-after-the-discovery-of-induced-pluripotent-stem-cells
#13
REVIEW
Andrea Barbuti, Patrizia Benzoni, Giulia Campostrini, Patrizia Dell'Era
Ten years ago Yamanaka's lab identified a way to reprogram terminally differentiated cells to a pluripotent state, similar to that of embryonic stem cell. This procedure opened the road for the generation of postmitotic human cells, that have completely lost the replication potential. The initial excitement waned when it was observed that the cells produced by this method are somehow immature and do not resemble the adult phenotype. In the absence of cellular markers that recognize the various maturation steps of induced pluripotent stem cell-derived human cardiomyocytes, we propose to follow their maturation looking at their electrophysiological profile...
December 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/27422791/bone-turnover-response-is-linked-to-both-acute-and-established-metabolic-changes-in-ultra-marathon-runners
#14
Veronica Sansoni, Gianluca Vernillo, Silvia Perego, Andrea Barbuti, Giampiero Merati, Federico Schena, Antonio La Torre, Giuseppe Banfi, Giovanni Lombardi
Bone and energy metabolisms regulation depends on a two-way street aimed at regulating energy utilization. Mountain ultra-marathons are highly demanding aerobic performances that deeply affect the whole body homeostasis. In this study we aimed to investigate and characterize the metabolic profile (in terms of hormones involved in energy metabolism), the inflammatory adipokines, and the bone turnover; in particular the osteocalcin-mediated response has been compared in experienced mountain ultra-marathons runners versus control subjects...
July 15, 2016: Endocrine
https://www.readbyqxmd.com/read/27276530/plasminogen-activator-inhibitor-1-as-a-marker-of-cardiovascular-response-in-professional-mountain-ultra-marathon-runners
#15
LETTER
Giovanni Lombardi, Gianluca Vernillo, Veronica Sansoni, Silvia Perego, Andrea Barbuti, Giampiero Merati, Federico Schena, Giuseppe Banfi, Antonio La Torre
No abstract text is available yet for this article.
January 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/26985660/localizing-tortoise-nests-by-neural-networks
#16
Roberto Barbuti, Stefano Chessa, Alessio Micheli, Rita Pucci
The goal of this research is to recognize the nest digging activity of tortoises using a device mounted atop the tortoise carapace. The device classifies tortoise movements in order to discriminate between nest digging, and non-digging activity (specifically walking and eating). Accelerometer data was collected from devices attached to the carapace of a number of tortoises during their two-month nesting period. Our system uses an accelerometer and an activity recognition system (ARS) which is modularly structured using an artificial neural network and an output filter...
2016: PloS One
https://www.readbyqxmd.com/read/26980505/prevalence-and-characterization-of-methicillin-resistant-staphylococcus-aureus-isolates-in-food-industry-workers
#17
G Caggiano, A Dambrosio, F Ioanna, S Balbino, G Barbuti, O De Giglio, G Diella, G Lovero, S Rutigliano, G Scarafile, A Baldassarre, L Vimercati, M Musti, M T Montagna
BACKGROUND: Methicillin-resistant S. aureus (MRSA) is a pathogen spread not only in the hospital environment but also in the community and amongst livestock (LA-MRSA). LA-MRSA can be transmitted to humans that live in close contact with MRSA-colonized animals, and human colonization and/or infection has been reported worldwide, particularly among those involved with livestock farming. In this study the authors evaluated the prevalence of S. aureus and MRSA among healthy carriers who worked in the food industry in Apulia, Southern Italy...
January 2016: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/26709802/higher-cardiogenic-potential-of-ipscs-derived-from-cardiac-versus-skin-stromal-cells
#18
Viviana Meraviglia, Jianyan Wen, Luca Piacentini, Giulia Campostrini, Cheng Wang, Maria Cristina Florio, Valerio Azzimato, Lorenzo Fassina, Martin Langes, Johnson Wong, Michele Miragoli, Carlo Gaetano, Giulio Pompilio, Andrea Barbuti, Dario DiFrancesco, Deborah Mascalzoni, Peter P Pramstaller, Gualtiero I Colombo, Huei-Sheng Vincent Chen, Alessandra Rossini
Prior studies have demonstrated that founder cell type could influence induced pluripotent stem cells (iPSCs) molecular and developmental properties at early passages after establishing their pluripotent state. Herein, we evaluated the persistence of a functional memory related to the tissue of origin in iPSCs from syngeneic cardiac (CStC) vs skin stromal cells (SStCs). We found that, at passages greater than 15, iPSCs from cardiac stromal cells (C-iPSCs) produced a higher number of beating embryoid bodies than iPSCs from skin stromal cells (S-iPSCs)...
January 1, 2016: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/26633515/paclitaxel-through-the-ages-of-anticancer-therapy-exploring-its-role-in-chemoresistance-and-radiation-therapy
#19
REVIEW
Anna Maria Barbuti, Zhe-Sheng Chen
Paclitaxel (Taxol(®)) is a member of the taxane class of anticancer drugs and one of the most common chemotherapeutic agents used against many forms of cancer. Paclitaxel is a microtubule-stabilizer that selectively arrests cells in the G2/M phase of the cell cycle, and found to induce cytotoxicity in a time and concentration-dependent manner. Paclitaxel has been embedded in novel drug formulations, including albumin and polymeric micelle nanoparticles, and applied to many anticancer treatment regimens due to its mechanism of action and radiation sensitizing effects...
2015: Cancers
https://www.readbyqxmd.com/read/26553542/a-gain-of-function-mutation-in-the-cardiac-pacemaker-hcn4-channel-increasing-camp-sensitivity-is-associated-with-familial-inappropriate-sinus-tachycardia
#20
Mirko Baruscotti, Annalisa Bucchi, Raffaella Milanesi, Manuel Paina, Andrea Barbuti, Tomaso Gnecchi-Ruscone, Elisabetta Bianco, Laura Vitali-Serdoz, Riccardo Cappato, Dario DiFrancesco
AIMS: Inappropriate Sinus Tachycardia (IST), a syndrome characterized by abnormally fast sinus rates and multisystem symptoms, is still poorly understood. Because of the relevance of HCN4 channels to pacemaker activity, we used a candidate-gene approach and screened IST patients for the presence of disease-causing HCN4 mutations. METHODS AND RESULTS: Forty-eight IST patients, four of whom of known familial history, were enrolled in the study. We initially identified in one of the patients with familial history the R524Q mutation in HCN4...
November 9, 2015: European Heart Journal
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