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https://www.readbyqxmd.com/read/28737859/association-between-dietary-glycemic-load-and-metabolic-syndrome-in-obese-children-and-adolescents
#1
Angela Cornejo-Monthedoro, Isel Negreiros-Sánchez, Carlos Del Águila, Marlit Ysla-Marquillo, Percy Mayta-Tristán
OBJETIVE: To study the association between the metabolic syndrome (MS) and the glycemic load (GL) of food intake among obese children and adolescents seen in consultation by the endocrinology team in a pediatric referral hospital in Lima, Peru. POPULATION AND METHOD: Cross-sectional study among obese children and adolescents (body mass index ≥ 95 percentile), 10-15 years old. The MS was classified according to criteria of the International Diabetes Federation...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28737815/isofraxidin-a-coumarin-component-improves-high-fat-diet-induced-hepatic-lipid-homeostasis-disorder-and-macrophage-inflammation-in-mice
#2
Jian Li, Xiaofei Li, Zhike Li, Lu Zhang, Yonggang Liu, Hong Ding, Shanye Yin
Isofraxidin (IF) is a coumarin compound produced in the functional foods Siberian ginseng and Apium graveolens. The first objective of this study was to investigate the protective effects and putative methods of IF in combating lipotoxicity in vitro and in vivo. Oleic acid was used to induce lipid turbulence in human hepatoma cells (HepG2). Alterations in triglyceride metabolism, inflammation and oxidative status were monitored. Results show that IF mainly reduced triglyceride accumulation, TNF-α release and ROS activation in metabolic disordered cells...
July 24, 2017: Food & Function
https://www.readbyqxmd.com/read/28737258/preclinical-alterations-in-myocardial-microstructure-in-people-with-metabolic-syndrome
#3
Jennifer E Ho, Youssef Rahban, Harpaul Sandhu, Pranoti G Hiremath, Nir Ayalon, Fuzhong Qin, Alejandro J Perez, Jill Downing, Deepa M Gopal, Susan Cheng, Wilson S Colucci
OBJECTIVE: Metabolic syndrome (MetS) can lead to myocardial fibrosis, diastolic dysfunction, and eventual heart failure. This study evaluated alterations in myocardial microstructure in people with MetS by using a novel algorithm to characterize ultrasonic signal intensity variation. METHODS: Among 254 participants without existing cardiovascular disease (mean age 42 ± 11 years, 75% women), there were 162 with MetS, 47 with obesity without MetS, and 45 nonobese controls...
July 24, 2017: Obesity
https://www.readbyqxmd.com/read/28736926/effects-of-testosterone-enanthate-treatment-in-conjunction-with-resistance-training-on-thyroid-hormones-and-lipid-profile-in-male-wistar-rats
#4
M Zarei, M Zaeemi, A Rashidlamir
This study was conducted to determine the effects of 8-week administration of testosterone enanthate (TE) in conjunction with resistance training on thyroid hormones and lipid profiles. Sixty male adult Wistar rats were randomly divided into six groups: C: olive oil, RT: resistance training + olive oil, LD: TE (20 mg/kg), HD: TE (50 mg/kg), RT + LD: RT + TE (20 mg/kg), RT + HD: RT + TE (50 mg/kg). The RT consisted of climbing (5 reps/3 sets) a ladder carrying a load suspended from the tail. At the end, blood specimens were obtained from the orbital sinus and serum concentration of T4, T3, TSH and lipid profiles was determined...
July 23, 2017: Andrologia
https://www.readbyqxmd.com/read/28736719/lipid-profile-in-adult-patients-with-fabry-disease-ten-year-follow-up
#5
Karolina M Stepien, Chris J Hendriksz
BACKGROUND: Fabry disease, an X-linked genetic condition, results from alpha-galactosidase deficiency and increased accumulation of glycosphingolipids in cardiovascular tissues. Clinical manifestation includes vasculature associated complications. Hyperlipidaemia is one of the cardiovascular risk factors however it has never been well defined in Fabry disease. Enzyme Replacement Therapy (ERT) is available but its effect on serum cholesterol is unknown. The aim of this project was to assess the influence of long-term ERT on lipid profile in a large cohort of adult patients with Fabry disease...
December 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28736440/repin1-deficiency-in-adipose-tissue-improves-whole-body-insulin-sensitivity-and-lipid-metabolism
#6
N Hesselbarth, A Kunath, M Kern, M Gericke, N Mejhert, M Rydén, M Stumvoll, M Blüher, N Klöting
BACKGROUND/OBJECTIVES: Replication initiator 1 (Repin1) gene encodes for a zinc-finger protein and has been implicated in the regulation of adipocyte cell size and glucose transport in vitro. Here, we investigate the consequences of reduced adipose tissue (AT) Repin1 expression in vivo. SUBJECTS/METHODS: We have inactivated the Repin1 gene in adipose tissue (iARep(-/-)) at an age of four weeks using tamoxifen-inducible gene targeting strategies on the background of C57BL/6NTac mice...
July 24, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28735818/curcuminoids-modify-lipid-profile-in-type-2-diabetes-mellitus-a-randomized-controlled-trial
#7
Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Željko Reiner, Muhammed Majeed, Amirhossein Sahbekar
BACKGROUND: Type 2 diabetes (T2D) is an established risk factor for cardiovascular disease (CVD) and is associated with disturbed metabolism of lipids and lipoproteins. Curcuminoids are natural products with anti-diabetic and lipid-modifying actions but their efficacy in improving dyslipidemia in diabetic individuals has not been sufficiently studied. OBJECTIVE: To investigate the efficacy of supplementation with curcuminoids, plus piperine as an absorption enhancer, in improving serum lipids in patients with T2D...
August 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28734987/bioavailable-and-free-25-hydroxyvitamin-d-and-vitamin-d-binding-protein-in-polycystic-ovary-syndrome-relationships-with-obesity-and-insulin-resistance
#8
Negar Naderpoor, Soulmaz Shorakae, Sally K Abell, Aya Mousa, Anju E Joham, Lisa J Moran, Nigel K Stepto, Poli Mara Spritzer, Helena J Teede, Barbora de Courten
Polycystic ovary syndrome (PCOS) is a common condition characterised by both reproductive and metabolic features (obesity, insulin resistance, diabetes risk). Some evidence suggests that women with PCOS have lower vitamin D levels compared to healthy controls. Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues. To our knowledge, no previous studies have examined DBP, bioavailable and free 25-hydroxyvitamin D (25(OH)D) in women with PCOS...
July 19, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28734591/increased-inflammatory-effect-of-electronegative-ldl-and-decreased-protection-by-hdl-in-type-2-diabetic-patients
#9
Montserrat Estruch, Inka Miñambres, Jose Luis Sanchez-Quesada, Marta Soler, Antonio Pérez, Jordi Ordoñez-Llanos, Sonia Benitez
BACKGROUND AND AIMS: Type 2 diabetic patients have an increased proportion of electronegative low-density lipoprotein (LDL(-)), an inflammatory LDL subfraction present in blood, and dysfunctional high-density lipoprotein (HDL). We aimed at examining the inflammatory effect of LDL(-) on monocytes and the counteracting effect of HDL in the context of type 2 diabetes. METHODS: This was a cross-sectional study in which the population comprised 3 groups (n = 12 in each group): type 2 diabetic patients with good glycaemic control (GC-T2DM patients), type 2 diabetic patients with poor glycaemic control (PC-T2DM), and a control group...
July 13, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28734036/-epicatechin-regulates-blood-lipids-and-attenuates-hepatic-steatosis-in-rats-fed-high-fat-diet-%C3%A2
#10
Hui Cheng, Na Xu, Wenxia Zhao, Jingjing Su, Mengru Liang, Zhongwen Xie, Xianli Wu, Qinglin Li
SCOPE: (-)-Epicatechin (EC) is a natural flavanol monomer found in cocoa, green tea and a variety of other plant foods. In this study, effects of EC on blood lipids and hepatic steatosis, and the underlying mechanisms were investigated. METHODS AND RESULTS: A hyperlipidemic rat model was induced by high-fat, high-cholesterol diet. EC was then administrated to the animals by gavage at doses of 10 mg/kg, 20 mg/kg, 40 mg/kg body weight (BW) for 12 weeks. Simvastatin was included as a positive control...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28733963/peroxisome-proliferator-activated-receptor-gamma-expression-in-peripheral-blood-mononuclear-cells-and-angiopoietin-like-protein-4-levels-in-obese-children-and-adolescents
#11
Z A Sadeghabadi, M Nourbakhsh, M Alaee, B Larijani, M Razzaghy-Azar
PURPOSE: The peroxisome proliferator-activated receptor γ (PPARγ) is highly expressed in adipose tissue and functions as transcriptional regulator of metabolism and adipocyte differentiation. Angiopoietin-like protein 4 (ANGPTL4), a central player in various aspects of energy homoeostasis, is induced by PPARγ. The aim of this study was to evaluate ANGPTL4 plasma levels and PPARγ gene expression in peripheral blood mononuclear cells (PBMCs) of children and adolescents with obesity and their association with metabolic parameters...
July 21, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28733725/carotid-artery-intimal-medial-thickness-and-carotid-artery-plaques-in-hypertensive-patients-with-non-arteritic-anterior-ischaemic-optic-neuropathy
#12
Wenhui Zhu, Tingting Chen, Ling Jin, Haoyu Wang, Fengjuan Yao, Congyao Wang, Qi Wang, Nathan Congdon
PURPOSE: To assess the correlation of carotid artery intimal medial thickness (C-IMT) and carotid artery plaque score (CPS) of the common carotid artery with non-arteritic anterior ischemic optic neuropathy (NAION) in hypertensive patients. METHODS: This case-control study recruited 192 subjects. Forty-eight patients had NAION with systemic hypertension, 46 had hypertension without visual complaints, and 98 were normal controls. C-IMT and common carotid arterial plaque were measured by high-resolution vascular ultrasonography...
July 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28733713/diel-cyclic-hypoxia-alters-plasma-lipid-dynamics-and-impairs-reproduction-in-goldfish-carassius-auratus
#13
Aritra Bera, Paramita Banerjee Sawant, Subrata Dasgupta, N K Chadha, Bhawesh T Sawant, Asim Kumar Pal
Diel cyclic hypoxia occurs with varying frequency and duration in freshwater habitats, yet little is known about its effects on reproduction of freshwater fishes. The present study shows that long-term exposure of goldfish (Carassius auratus) to cyclic hypoxia (0.8 ± 0.2 mg/l dissolved oxygen) for 9 h or more, per day, altered plasma lipid and sex steroid profiles, which in turn directly or indirectly suppressed ovarian growth and viable spermatozoa production. Hypoxia decreased total cholesterol and high density lipoprotein (HDL p < 0...
July 21, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/28733174/lipoprotein-insulin-resistance-score-and-risk-of-incident-diabetes-during-extended-follow-up-of-20%C3%A2-years-the-women-s-health-study
#14
Paulo H N Harada, Olga V Demler, Sagar B Dugani, Akintunde O Akinkuolie, Manickavasagar V Moorthy, Paul M Ridker, Nancy R Cook, Aruna D Pradhan, Samia Mora
BACKGROUND: Type II diabetes (T2D) is preceded by prolonged insulin resistance and relative insulin deficiency incompletely captured by glucose metabolism parameters, high-density lipoprotein (HDL) cholesterol and triglycerides. OBJECTIVE: Whether lipoprotein insulin resistance (LPIR) score, a metabolomic marker, is associated with incident diabetes and improves risk reclassification over traditional markers on extended follow-up. METHODS: Among 25,925 nondiabetic women aged 45 years or older, LPIR was measured by nuclear magnetic resonance spectroscopy as a weighted score of very low density lipoprotein, low-density lipoprotein, and HDL particle sizes, and their subsets concentrations...
June 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28732570/incident-type-2-diabetes-is-associated-with-hdl-but-not-with-its-anti-oxidant-constituent-paraoxonase-1-the-prospective-cohort-prevend-study
#15
Setor K Kunutsor, Lyanne M Kieneker, Stephan J L Bakker, Richard W James, Robin P F Dullaart
OBJECTIVE: High-density lipoprotein cholesterol (HDL-C) is an established risk marker for cardiovascular disease and consistently associated with type 2 diabetes risk. Serum paraoxonase-1 (PON-1) - an anti-oxidant constituent of HDL - is inversely associated with cardiovascular disease risk, but its relationship with incident type 2 diabetes is uncertain. We aimed to investigate the prospective association between PON-1 and type 2 diabetes risk. METHODS: PON-1 was measured as its arylesterase activity at baseline in the Prevention of Renal and Vascular End-stage Disease (PREVEND) prospective study of 5947 predominantly Caucasian participants aged 28-75years with no pre-existing diabetes, that recorded 500 type 2 diabetes cases during a median follow-up of 11...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28732568/effects-of-oral-contraceptives-on-metabolic-profile-in-women-with-polycystic-ovary-syndrome-a-meta-analysis-comparing-products-containing-cyproterone-acetate-with-third-generation-progestins
#16
REVIEW
Mina Amiri, Fahimeh Ramezani Tehrani, Fatemeh Nahidi, Ali Kabir, Fereidoun Azizi, Enrico Carmina
BACKGROUND: Although oral contraceptives (OCs) are the most common treatment in women with polycystic ovary syndrome (PCOS), their effects and safety on the metabolic profiles of these patients are relatively unknown. In this meta-analysis the effects of the different durations (from 3months to 1year) of OC treatment using cyproterone acetate (CA) or third generation progestins on metabolic profile of patients with PCOS were assessed. MATERIALS AND METHODS: PubMed, Scopus, Google Scholar and ScienceDirect databases (2001-2015) were searched to identify clinical trials investigating the effects of OC containing CA or third generation progestins on metabolic profiles of women with PCOS...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28731861/genetic-control-of-apoprotein-a-i-and-atheroprotection-some-insights-from-inbred-strains-of-mice
#17
Godfrey S Getz, Catherine A Reardon
PURPOSE OF REVIEW: Previous epidemiological studies and studies in experimental animals have provided strong evidence for the atheroprotective effect of HDL and its major apoprotein, apolipoprotein A-I (apoA-I). Identification of genetic loci associating apoA-I/HDL with cardiovascular disease is needed to establish a causal relationship. RECENT FINDINGS: Pharmacological interventions to increase apoA-I or HDL cholesterol levels in humans are not associated with reduction in atherosclerosis...
July 20, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28731557/data-mining-potential-applications-in-research-on-nutrition-and-health
#18
Marijka Batterham, Elizabeth Neale, Allison Martin, Linda Tapsell
AIM: Data mining enables further insights from nutrition-related research, but caution is required. The aim of this analysis was to demonstrate and compare the utility of data mining methods in classifying a categorical outcome derived from a nutrition-related intervention. METHODS: Baseline data (23 variables, 8 categorical) on participants (n = 295) in an intervention trial were used to classify participants in terms of meeting the criteria of achieving 10 000 steps per day...
February 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28731431/association-between-cholesterol-exposure-and-neuropathological-findings-the-act-study
#19
Brianne M Bettcher, M Colin Ard, Bruce R Reed, Andreana Benitez, Amanda Simmons, Eric B Larson, Josh A Sonnen, Thomas J Montine, Ge Li, C Dirk Keene, Paul K Crane, Dan Mungas
We characterized the relationship between late life cholesterol exposure and neuropathological outcomes in a community-based, older adult cohort. Adult Changes in Thought (ACT) is a cohort study that enrolls consenting, randomly selected, non-demented people aged ≥65 from a healthcare delivery system. We used late life HDL and total cholesterol lab values from Group Health computerized records, and calculated HDL and non-HDL levels. We evaluated neuropathological outcomes of Alzheimer's disease, cerebral amyloid angiopathy, vascular brain injury, and Lewy body disease...
July 19, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28731315/hypocholesterolemic-activity-of-cornelian-cherry-cornus-mas-l-fruits
#20
Fatemeh Hosseinpour, Tahoora Shomali, Mahmoud Rafieian-Kopaei
Background Lipid profile disturbances are important risk factors for cardiovascular events in patients with diabetes mellitus and finding safe and multifaceted agents is persuaded in this regard. This study aimed to evaluate the effect of cornelian cherry dried powder (CCDP) on serum lipid profile as well as liver antioxidant capacity, HMG-CoA reductase level and activity, and LDL receptor level in streptozotocin-induced diabetic rats. Methods Forty-eight male adult Wistar rats were randomly allocated into eight equal groups and were treated for 4 weeks as follows: negative control (normal rats, basic diet); positive control (diabetic rats, basic diet), T1 to T4 groups: diabetic rats fed with basic diet containing 0...
June 1, 2017: Journal of Complementary & Integrative Medicine
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