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JOURNAL ARTICLE
Yang Weng, Yuki Sekimori, Sehwa Chun, Omar Alkhazragi, Takumi Matsuda, Abderrahmen Trichili, Tien Khee Ng, Boon S Ooi, Toshihiro Maki
The development of multiple autonomous underwater vehicles (AUVs) has revolutionized the traditional reliance on a single, costly AUV for conducting underwater surveys. This shift has garnered increasing interest among marine researchers. Communication between AUV fleets is an urgent concern due to the data rate limitation of underwater acoustic communication. Laser-based underwater wireless optical communication (UWOC) is a potential solution once the link-establishing requirement between AUVs can be met. Due to the limited coverage area of the laser beam, the previous pointing, acquisition, and tracking (PAT) method is to quickly adjust the beam direction and search for the target according to the set scanning path...
November 1, 2023: Applied Optics
#22
JOURNAL ARTICLE
Eva Aalbregt, Reza Indrakusuma, Hamid Jalalzadeh, R Nils Planken, Joost van Schuppen, Lilian Meijboom, Ron Balm, Aart J Nederveen, Kak Khee Yeung, Pim van Ooij
BACKGROUND: Maximum diameter measurements are used to assess the rupture risk of abdominal aortic aneurysms (AAAs); however, these are not precise enough to predict all ruptures. Four-dimensional (4D) flow MRI-derived parameters provide additional information by visualizing hemodynamics in AAAs but merit further investigation before they are clinically applicable. PURPOSE: To assess the reproducibility of 4D flow MRI-derived hemodynamics, to investigate possible correlations with lumen and maximum diameter, and to explore potential relationships with vorticity and aneurysm growth...
November 25, 2023: Journal of Magnetic Resonance Imaging: JMRI
#23
JOURNAL ARTICLE
Mayank Dalakoti, Melvin Khee Shing Leow, Chin Meng Khoo, Hayang Yang, Lieng Hsi Ling, Mark Muthiah, Eunice Tan, Jonathan Lee, Yock Young Dan, Nicholas Chew, Wei Qiang Seow, Poh Loong Soong, Louis Gan, Rijan Gurung, Matthew Ackers-Johnson, Han Wei Hou, Karishma Sachaphibulkij, Paul MacAry, Gwen Low, Christy Ang, Tee Joo Yeo, Andie Hartanto Djohan, Tony Li, Wesley Yeung, Rodney Soh, Ching Hui Sia, Vinay Panday, Shaun S E Loong, Benjamin Y Q Tan, Leonard L L Yeo, Lynette Teo, Pierce Chow, Roger Foo
Through extensive multisystem phenotyping, the central aim of Project PICMAN is to correlate metabolic flexibility to measures of cardiometabolic health, including myocardial diastolic dysfunction, coronary and cerebral atherosclerosis, body fat distribution and severity of non-alcoholic fatty liver disease. This cohort will form the basis of larger interventional trials targeting metabolic inflexibility in the prevention of cardiovascular disease. Participants aged 21-72 years with no prior manifest atherosclerotic cardiovascular disease (ASCVD) are being recruited from a preventive cardiology clinic and an existing cohort of non-alcoholic fatty liver disease (NAFLD) in an academic medical centre...
November 22, 2023: Scientific Reports
#24
JOURNAL ARTICLE
Benjamin Gebauer, Kilian-Simon Baumann, Hermann Fuchs, Dietmar Georg, Brad M Oborn, Hui-Khee Looe, Armin Lühr
BACKGROUND: The combination of magnetic resonance imaging and proton therapy offers the potential to improve cancer treatment. The magnetic field (MF)-dependent change in the dosage of ionization chambers in magnetic resonance imaging-integrated proton therapy (MRiPT) is considered by the correction factor <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:semantics><mml:msub><mml:mi>k</mml:mi> <mml:mrow><mml:mover><mml:mi>B</mml:mi> <mml:mo>⃗</mml:mo></mml:mover> <mml:mo>,</mml:mo> <mml:mi>M</mml:mi> <mml:mo>,</mml:mo> <mml:mi>Q</mml:mi></mml:mrow> </mml:msub> <mml:annotation>$k_{\vec{B},M,Q}$</mml:annotation></mml:semantics> </mml:math> , which needs to be determined experimentally or computed via Monte Carlo (MC) simulations...
October 28, 2023: Medical Physics
#25
JOURNAL ARTICLE
Yeshe M Kway, Kashthuri Thirumurugan, Navin Michael, Kok Hian Tan, Keith M Godfrey, Peter Gluckman, Yap Seng Chong, Kavita Venkataraman, Eric Yin Hao Khoo, Chin Meng Khoo, Melvin Khee-Shing Leow, E Shyong Tai, Jerry Ky Chan, Shiao-Yng Chan, Johan G Eriksson, Marielle V Fortier, Yung Seng Lee, S Sendhil Velan, Mengling Feng, Suresh Anand Sadananthan
BACKGROUND: Existing literature has highlighted structural, physiological, and pathological disparities among abdominal adipose tissue (AAT) sub-depots. Accurate separation and quantification of these sub-depots are crucial for advancing our understanding of obesity and its comorbidities. However, the absence of clear boundaries between the sub-depots in medical imaging data has challenged their separation, particularly for internal adipose tissue (IAT) sub-depots. To date, the quantification of AAT sub-depots remains challenging, marked by a time-consuming, costly, and complex process...
October 18, 2023: Computers in Biology and Medicine
#26
JOURNAL ARTICLE
Chien-Ming Chao, Chih-Cheng Lai, Khee-Siang Chan, Chun-Chieh Yang, Chin-Ming Chen, Chung-Han Ho, Hsuan-Fu Ou, Wen-Liang Yu
BACKGROUND: Previous studies have revealed higher mortality rates in patients of severe influenza coinfected with invasive pulmonary aspergillosis (IPA) than in those without the coinfection; nonetheless, the clinical outcome of IPA in critically ill patients without influenza remains unclear. PATIENTS AND METHODS: This retrospective study was conducted in three institutes. From 2016-2018, all adult patients diagnosed with IPA in the intensive care units (ICUs) were identified...
September 28, 2023: Journal of Infection and Public Health
#27
JOURNAL ARTICLE
Nicholas Purser, Ishita Tripathi-Giesgen, Jerry Li, Daniel C Scott, Daniel Horn-Ghetko, Khee Baek, Brenda Schulman, Arno Alpi, Gary Kleiger
Protein ubiquitylation typically involves isopeptide bond formation between the C-terminus of ubiquitin to the side-chain amino group on Lys residues. However, several ubiquitin ligases (E3s) have recently been identified that ubiquitylate proteins on non-Lys residues. For instance, HOIL-1 belongs to the RING-in-between RING (RBR) class of E3s and has an established role in Ser ubiquitylation. Given the homology between HOIL-1 and ARIH1, an RBR E3 that functions with the large superfamily of cullin-RING E3 ligases (CRLs), a biochemical investigation was undertaken, showing ARIH1 catalyzes Ser ubiquitylation to CRL-bound substrates...
October 23, 2023: Biochemical Journal
#28
REVIEW
Fabien Lareyre, Kak Khee Yeung, Lisa Guzzi, Gilles Di Lorenzo, Arindam Chaudhuri, Christian-Alexander Behrendt, Konstantinos Spanos, Juliette Raffort
Despite advances in prevention, detection, and treatment, cardiovascular disease is a leading cause of mortality and represents a major health problem worldwide. Artificial intelligence and machine learning have brought new insights to the management of vascular diseases by allowing analysis of huge and complex datasets and by offering new techniques to develop advanced imaging analysis. Artificial intelligence-based applications have the potential to improve prognostic evaluation and evidence-based decision making and contribute to vascular therapeutic decision making...
September 2023: Seminars in Vascular Surgery
#29
JOURNAL ARTICLE
Yue Wang, Jian-Xin Wang, Omar Alkhazragi, Luis Gutiérrez-Arzaluz, Huafan Zhang, Chun Hong Kang, Tien Khee Ng, Osman M Bakr, Omar F Mohammed, Boon S Ooi
The last decade has witnessed considerable progress in underwater wireless optical communication in complex environments, particularly in exploring the deep sea. However, it is difficult to maintain a precise point-to-point reception at all times due to severe turbulence in actual situations. To facilitate efficient data transmission, the color-conversion technique offers a paradigm shift in large-area and omnidirectional light detection, which can effectively alleviate the étendue limit by decoupling the field of view and optical gain...
September 25, 2023: Optics Express
#30
REVIEW
Eva Aalbregt, Lotte Rijken, Aart Nederveen, Pim van Ooij, Kak Khee Yeung, Vincent Jongkind
PURPOSE: In current practice, the diameter of an aortic aneurysm is utilized to estimate the rupture risk and decide upon timing of elective repair, although it is known to be imprecise and not patient-specific. Quantitative magnetic resonance imaging (MRI) enables the visualization of several biomarkers that provide information about processes within the aneurysm and may therefore facilitate patient-specific risk stratification. We performed a scoping review of the literature on quantitative MRI techniques to assess aortic aneurysm progression and rupture risk, summarized these findings, and identified knowledge gaps...
October 18, 2023: Journal of Endovascular Therapy
#31
Melvin Khee Shing Leow, Joshur Ang, Xinyan Bi, Ee Tzun Koh, Craig McFarlane
BACKGROUND/OBJECTIVE: Tumoral calcinosis (TC) is a rare, arcane, and debilitating disorder of phosphate metabolism manifesting as hard masses in soft tissues. Primary hyperphosphatemic TC has been shown to be caused by pathogenic variants in the genes encoding FGF23, GALNT3, and KLOTHO. We report a case of massive TC mechanistically associated with phosphatonin resistance associated with heterozygous alterations in the sterile alfa motif domain-containing protein-9 gene ( SAMD9 ), alfa 2-Heremans-Schmid glycoprotein gene ( AHSG ), FSHD region gene 2-family member-C gene ( FRG2C ), and fibroblast growth factor receptor-4 gene ( FGFR4 )...
2023: AACE Clinical Case Reports
#32
JOURNAL ARTICLE
Yujian Guo, Juan M Marin, Islam Ashry, Abderrahmen Trichili, Michelle-Nicole Havlik, Tien Khee Ng, Carlos M Duarte, Boon S Ooi
Oceans are crucial to human survival, providing natural resources and most of the global oxygen supply, and are responsible for a large portion of worldwide economic development. Although it is widely considered a silent world, the sea is filled with natural sounds generated by marine life and geological processes. Man-made underwater sounds, such as active sonars, maritime traffic, and offshore oil and mineral exploration, have significantly affected underwater soundscapes and species. In this work, we report on a joint optical fiber-based communication and sensing technology aiming to reduce noise pollution in the sea while providing connectivity simultaneously with a variety of underwater applications...
September 18, 2023: Scientific Reports
#33
JOURNAL ARTICLE
Sultan Alshaibani, Omar Alkhazragi, Islam Ashry, Chun Hong Kang, Mohammed Sait, Tien Khee Ng, Osman M Bakr, Boon S Ooi
Optical wireless communication (OWC) links suffer from strict requirements of pointing, acquisition, and tracking (PAT) between the transmitter and receiver. Extending the narrow field-of-view (FoV) of conventional light-focusing elements at the receiver side can relax the PAT requirements. Herein, we use all-inorganic CsPbBr3 nanocrystals (NCs) to extend various optical concentrators' FOV to 60°, regardless of the original FOV values of the concentrators. Given the robustness of UV light against communication channel misalignment, the used CsPbBr3 NCs provide another advantage of converting transmitted UVC light into a green color that matches the peak absorption of the widely available Si-based detectors...
July 31, 2023: Optics Express
#34
REVIEW
Frank Hoexum, Max Hoebink, Hans M E Coveliers, Willem Wisselink, Vincent Jongkind, Kak Khee Yeung
OBJECTIVE: Currently, there is no consensus on the optimal management of Paget-Schroetter syndrome (PSS). Our objective was to summarise current evidence for management of PSS with explicit attention to the clinical outcomes of different management strategies. DATA SOURCES: The Cochrane, PubMed, and Embase databases were searched for reports published between January 1990 and December 2021. REVIEW METHODS: A systematic review and meta-analysis was conducted following PRISMA 2020 guidelines...
September 5, 2023: European Journal of Vascular and Endovascular Surgery
#35
JOURNAL ARTICLE
James Tan, Xuncheng Shi, Kunze Lu, Hyo-Jun Joo, Youngmin Kim, Melvina Chen, Lin Zhang, Chuan Seng Tan, Khee Yong Lim, Elgin Quek, Donguk Nam
Quantum photonic circuits have recently attracted much attention owing to the potential to achieve exceptional performance improvements over conventional classical electronic circuits. Second-order χ(2) nonlinear processes play an important role in the realization of several key quantum photonic components. However, owing to their centrosymmetric nature, CMOS-compatible materials including silicon (Si) and germanium (Ge) traditionally do not possess the χ(2) response. Recently, second-harmonic generation (SHG) that requires the χ(2) response was reported in Ge, but no attempts at enhancing the SHG signal have been conducted and proven experimentally...
August 15, 2023: Optics Letters
#36
JOURNAL ARTICLE
Jian-Xin Wang, Yue Wang, Maram Almalki, Jun Yin, Osama Shekhah, Jiangtao Jia, Luis Gutiérrez-Arzaluz, Youdong Cheng, Omar Alkhazragi, Vijay K Maka, Tien Khee Ng, Osman M Bakr, Boon S Ooi, Mohamed Eddaoudi, Omar F Mohammed
Metal-organic frameworks (MOFs) have emerged as excellent platforms possessing tunable and controllable optical behaviors that are essential in high-speed and multichannel data transmission in optical wireless communications (OWCs). Here, we demonstrate a novel approach to achieving a tunable wide modulation bandwidth and high net data rate by engineering a combination of organic linkers and metal clusters in MOFs. More specifically, two organic linkers of different emission colors, but equal molecular length and connectivity, are successfully coordinated by zirconium and hafnium oxy-hydroxy clusters to form the desired MOF structures...
July 8, 2023: Journal of the American Chemical Society
#37
JOURNAL ARTICLE
Marina Dias-Neto, Andrea Varcica, Ying Huang, Aidin Baghbani-Oskouei, Tomasz Jakimowicz, Bernardo C Mendes, Tilo Kolbel, Jonathan Sobocinski, Luca Bertoglio, Barend Mees, Mauro Gargiulo, Nuno Dias, Andres Schanzer, Warren Gasper, Adam W Beck, Mark A Farber, Kevin Mani, Carlos Timaran, Darren B Schneider, Luis Mendes Pedro, Nikolaos Tsilimparis, Stéphan Haulon, Matthew P Sweet, Emília Ferreira, Matthew Eagleton, Kak Khee Yeung, Manar Khashram, Katarzyna Jama, Giuseppe Panuccio, Fiona Rohlffs, Thomas Mesnard, Roberto Chiesa, Andrea Kahlberg, Geert Willem Schurink, Charlotte Lemmens, Enrico Gallitto, Gianluca Faggioli, Angelos Karelis, Ezequiel Parodi, Vivian Gomes, Anders Wanhainen, Mohammed Habib, Jesus Porras Colon, Felipe Pavarino, Mirza S Baig, Ryan Eduardo Costeloe De Gouveia E Melo, Sean Crawford, Sara L Zettervall, Rita Garcia, Tiago Ribeiro, Gonçalo Alves, Frederico Bastos Gonçalves, Kaj Olav Kappe, Samira Elize Mariko van Knippenberg, Bich Lan Tran, Sinead Gormley, Gustavo S Oderich
OBJECTIVE: To describe outcomes after elective and non-elective fenestrated-branched endovascular aortic repair (FB-EVAR) for thoracoabdominal aortic aneurysms (TAAAs). SUMMARY OF BACKGROUND DATA: FB-EVAR has been increasingly utilized to treat TAAAs; however, outcomes after non-elective versus elective repair are not well described. METHODS: Clinical data of consecutive patients undergoing FB-EVAR for TAAAs at 24 centers (2006-2021) were reviewed...
July 3, 2023: Annals of Surgery
#38
JOURNAL ARTICLE
Jericho Wee, Xiang Ren Tan, Samuel H Gunther, Mohammed Ihsan, Melvin Khee Shing Leow, Doreen Su-Yin Tan, Johan G Eriksson, Jason Kai Wei Lee
Pharmacological agents used to treat or manage diseases can modify the level of heat strain experienced by chronically ill and elderly patients via different mechanistic pathways. Human thermoregulation is a crucial homeostatic process that maintains body temperature within a narrow range during heat stress through dry (i.e., increasing skin blood flow) and evaporative (i.e., sweating) heat loss, as well as active inhibition of thermogenesis, which is crucial to avoid overheating. Medications can independently and synergistically interact with ageing and chronic disease to alter homeostatic responses to rising body temperature during heat stress...
June 16, 2023: Pharmacological Reviews
#39
JOURNAL ARTICLE
Jeremy Wee Kiat Ng, Kar Wai Tan, Dian Yan Guo, Joey Jia Hui Lai, Xiubo Fan, Zhiyong Poon, Tse Hui Lim, Alvin Soon Tiong Lim, Tony Kiat Hon Lim, William Ying Khee Hwang, Shang Li, Connie J Eaves, Yeow Tee Goh, Alice Man Sze Cheung
Human cord blood-derived γδ T cells (CBγδ ) display a highly diverse TCRγδ repertoire and have a unique subtype composition different from fetal or adult peripheral blood counterparts. We expanded CBγδ in vitro using an irradiated Epstein-Barr virus-transformed feeder cell-based modified rapid expansion protocol (REP). Single-cell RNA sequencing tracked progressive differentiation of naïve CBγδ into cells expressing neoantigen-reactive tumor-infiltrating lymphocyte as well as tissue-resident memory precursor-like and antigen-presenting cell-like gene signatures...
June 16, 2023: Science Advances
#40
JOURNAL ARTICLE
Luís Duarte-Gamas, Filipa Jácome, Lara Romana Dias, João Rocha-Neves, Kak K Yeung, Niels Baekgaard, Marina Dias-Neto
OBJECTIVE: To summarize characteristics, complications, and success rates of different catheter-directed thrombolysis (CDT) protocols for the treatment of lower extremity deep venous thrombosis (LE-DVT). METHODS: A systematic review using electronic databases (MEDLINE, Scopus, and Web of Science) was performed to identify randomized controlled trials and observational studies related to LE-DVT treated with CDT. A random-effects model meta-analysis was performed to obtain the pooled proportions of early complications, postthrombotic syndrome (PTS), and venous patency...
February 2024: Thrombosis and Haemostasis
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