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https://www.readbyqxmd.com/read/29772933/the-approach-to-solitary-fibrous-tumors-are-clinicopathological-features-and-nomograms-accurate-in-the-prediction-of-prognosis
#1
Deanna Wan Jie Ng, Grace Hwei Ching Tan, Joel Jia Yi Soon, David Yue Zhao, Nicholas Brian Shannon, Sathiyamoorthy Selvarajan, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: Currently, factors such as size, mitotic rate, and degree of necrosis have been shown to influence survival in patients with solitary fibrous tumors (SFTs); however, there remains no consensus regarding the associations between tumor characteristics and the malignant nature of these tumors. The aim of this article was to identify factors that would help in prognosticating SFTs and to validate the MD Anderson Cancer Center (MDACC) SFT nomogram in the largest known series of SFTs treated in an Asian population...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29764160/combinatorial-strategies-of-radiotherapy-and-immunotherapy-in-nasopharyngeal-carcinoma
#2
Eugenia L L Yeo, You Quan Li, Khee-Chee Soo, Joseph T S Wee, Melvin L K Chua
Immunotherapy and radiation therapy (RT) have each demonstrated clinical success in the treatment of nasopharyngeal carcinoma (NPC) when utilized independently. Several characteristics of NPC make it particularly well suited for immunotherapeutic strategies, such as the association with viral infections like EBV and human papilloma virus (HPV), upregulation of PD-L1 expression, and the high number of tumor infiltrating lymphocytes. Immune checkpoint blockade is one such immunotherapeutic strategy that is gaining popularity rapidly...
April 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29745794/visceral-adipose-tissue-tracks-more-closely-with-metabolic-dysfunction-than-intrahepatic-triglyceride-in-non-diabetic-lean-asians
#3
Cherlyn Ding, Zhiling Chan, Yu Chung Chooi, John Choo, Suresh Anand Sadananthan, Navin Michael, S Sendhil Velan, Melvin Khee-Shing Leow, Faidon Magkos
BACKGROUND: Increased visceral adipose tissue (VAT) and intrahepatic triglyceride (IHTG) are important risk factors for the development of type 2 diabetes in obese subjects. The relative contribution of these ectopic fat depots to cardiometabolic risk differs between populations, depends on the degree of obesity and the level of cardiorespiratory fitness, and is difficult to dissect because VAT and IHTG typically co-vary. The aim of this study was to evaluate the effect of an isolated increase in VAT or IHTG on insulin sensitivity and insulin secretion in apparently healthy normal-weight Asian subjects...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29718334/low-dose-levothyroxine-reduces-intrahepatic-lipid-content-in-patients-with-type-2-diabetes-mellitus-and-nafld
#4
Eveline Bruinstroop, Rinkoo Dalan, Cao Yang, Yong Mong Bee, Kurumbian Chandran, Li Wei Cho, Shui Boon Soh, Eng Kiong Teo, Sue-Anne Toh, Melvin Khee Shing Leow, Rohit A Sinha, Suresh Anand Sadananthan, Navin Michael, Heather Stapleton, Christopher Leung, Peter W Angus, Sheila K Patel, Louise M Burrell, Lim Su Chi, Sum Chee Fang, S Sendhil Velan, Paul M Yen
Context/Objective: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in patients with type 2 diabetes mellitus and associated with significant morbidity and mortality. Thyroid hormone (TH) increases β-oxidation of fatty acids and decreases intrahepatic lipid content (IHLC) in rodents with NAFLD. In this study we investigated the possibility of low intrahepatic TH concentration in NAFLD and studied the effect of TH treatment in humans. Design/Setting: We performed a phase 2b single arm study in six hospitals in Singapore to study whether TH reduced IHLC...
April 27, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29683137/erratum-author-correction-angiotensin-type-2-receptor-activation-promotes-browning-of-white-adipose-tissue-and-brown-adipogenesis
#5
Aung Than, Shaohai Xu, Ru Li, Melvin Khee-Shing Leow, Lei Sun, Peng Chen
[This corrects the article DOI: 10.1038/sigtrans.2017.22.].
2018: Signal Transduction and Targeted Therapy
https://www.readbyqxmd.com/read/29663621/neurodevelopmental-outcomes-of-young-children-born-to-hiv-positive-mothers-in-rural-yunnan-china
#6
Jie Wu, Jing Li, Yan Li, Kek Khee Loo, Haixia Yang, Qiong Wang, Rufei Duan, Xia Xiao, Xiaoxiao Song, Siwei Yang, Lin Sun
BACKGROUND: Children born to HIV-infected mothers are at risk for neurodevelopmental delay. Little is known about neurodevelopmental outcomes of infants and toddlers who were born to HIV-positive mothers but were not themselves infected by HIV, especially in poor rural areas. This study was conducted to compare developmental outcomes between young children who were HIV-exposed but uninfected (HEU) and their HIV-unexposed and uninfected (HUU) peers in rural Yunnan, China. METHODS: A total of 250 HEU children aged 6-36 months and 250 HUU children matched on age, gender and residency were recruited from rural Yunnan, China...
April 16, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29626186/de-novo-reconstruction-of-human-adipose-transcriptome-reveals-conserved-lncrnas-as-regulators-of-brown-adipogenesis
#7
Chunming Ding, Yen Ching Lim, Sook Yoong Chia, Arcinas Camille Esther Walet, Shaohai Xu, Kinyui Alice Lo, Yanling Zhao, Dewen Zhu, Zhihui Shan, Qingfeng Chen, Melvin Khee-Shing Leow, Dan Xu, Lei Sun
Obesity has emerged as an alarming health crisis due to its association with metabolic risk factors such as diabetes, dyslipidemia, and hypertension. Recent work has demonstrated the multifaceted roles of lncRNAs in regulating mouse adipose development, but their implication in human adipocytes remains largely unknown. Here we present a catalog of 3149 adipose active lncRNAs, of which 909 are specifically detected in brown adipose tissue (BAT) by performing deep RNA-seq on adult subcutaneous, omental white adipose tissue and fetal BATs...
April 6, 2018: Nature Communications
https://www.readbyqxmd.com/read/29609349/free-space-optical-channel-characterization-and-experimental-validation-in-a-coastal-environment
#8
Wael G Alheadary, Ki-Hong Park, Nasir Alfaraj, Yujian Guo, Edgars Stegenburgs, Tien Khee Ng, Boon S Ooi, Mohamed-Slim Alouini
Over the years, free-space optical (FSO) communication has attracted considerable research interest owing to its high transmission rates via the unbounded and unlicensed bandwidths. Nevertheless, various weather conditions lead to significant deterioration of the FSO link capabilities. In this context, we report on the modelling of the channel attenuation coefficient (β) for a coastal environment and related ambient, considering the effect of coastal air temperature (T), relative humidity (RH) and dew point (TD) by employing a mobile FSO communication system capable of achieving a transmission rate of 1 Gbps at an outdoor distance of 70 m for optical beam wavelengths of 1310 nm and 1550 nm...
March 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29609284/semipolar-ingan-quantum-well-laser-diode-with-integrated-amplifier-for-visible-light-communications
#9
Chao Shen, Tien Khee Ng, Changmin Lee, Shuji Nakamura, James S Speck, Steven P DenBaars, Ahmed Y Alyamani, Munir M El-Desouki, Boon S Ooi
GaN-based semiconductor optical amplifier (SOA) and its integration with laser diode (LD) is an essential building block yet to be demonstrated for III-nitride photonic integrated circuits (PICs) at visible wavelength. This paper presents the InGaN/GaN quantum well (QW) based dual-section LD consisting of integrated amplifier and laser gain regions fabricated on a semipolar GaN substrate. The threshold current in the laser gain region was favorably reduced from 229mA to 135mA at SOA driving voltages, VSOA , of 0V and 6...
March 19, 2018: Optics Express
https://www.readbyqxmd.com/read/29519872/adipocyte-long-noncoding-rna-transcriptome-analysis-of-obese-mice-identified-lnc-leptin-which-regulates-leptin
#10
Kinyui Alice Lo, Shiqi Huang, Arcinas Camille Esther Walet, Zhi-Chun Zhang, Melvin Khee-Shing Leow, Meihui Liu, Lei Sun
Obesity induces profound transcriptome changes in adipocytes; recent evidence suggests that lncRNAs play key roles in this process. Here, we performed a comprehensive transcriptome study by RNA-Seq in adipocytes isolated from interscapular brown, inguinal and epididymal white adipose tissues in diet-induced obese mice. Our analysis reveals a set of obesity-dysregulated lncRNAs, many of which exhibit dynamic changes in fed vs. fasted state, potentially serving as novel molecular markers reflecting adipose energy status...
March 8, 2018: Diabetes
https://www.readbyqxmd.com/read/29516870/2d-convolution-kernels-of-ionization-chambers-used-for-photon-beam-dosimetry-in-magnetic-fields-the-advantage-of-small-over-large-chamber-dimensions
#11
Hui Khee Looe, Björn Delfs, Daniela Poppinga, Dietrich Harder, Björn Poppe
This study aims at developing an optimization strategy for photon-beam dosimetry in magnetic fields using ionization chambers. Similar to the familiar case in the absence of a magnetic field, detectors should be selected under the criterion that their measured 2D signal profiles M(x,y) approximate the absorbed dose to water profiles D(x,y) as closely as possible. Since the conversion of D(x,y) into M(x,y) is known as the convolution with the 'lateral dose response function' K(x-ξ, y-η) of the detector, the ideal detector would be characterized by a vanishing magnetic field dependence of this convolution kernel (Looe et al 2017b Phys...
March 29, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29498924/sirvenib-selective-internal-radiation-therapy-versus-sorafenib-in-asia-pacific-patients-with-hepatocellular-carcinoma
#12
Pierce K H Chow, Mihir Gandhi, Say-Beng Tan, Maung Win Khin, Ariunaa Khasbazar, Janus Ong, Su Pin Choo, Peng Chung Cheow, Chanisa Chotipanich, Kieron Lim, Laurentius A Lesmana, Tjakra W Manuaba, Boon Koon Yoong, Aloysius Raj, Chiong Soon Law, Ian H Y Cua, Rolley R Lobo, Catherine S C Teh, Yun Hwan Kim, Yun Won Jong, Ho-Seong Han, Si-Hyun Bae, Hyun-Ki Yoon, Rheun-Chuan Lee, Chien-Fu Hung, Cheng-Yuan Peng, Po-Chin Liang, Adam Bartlett, Kenneth Y Y Kok, Choon-Hua Thng, Albert Su-Chong Low, Anthony S W Goh, Kiang Hiong Tay, Richard H G Lo, Brian K P Goh, David C E Ng, Ganesh Lekurwale, Wei Ming Liew, Val Gebski, Kenneth S W Mak, Khee Chee Soo
Purpose Selective internal radiation therapy or radioembolization (RE) shows efficacy in unresectable hepatocellular carcinoma (HCC) limited to the liver. This study compared the safety and efficacy of RE and sorafenib in patients with locally advanced HCC. Patients and Methods SIRveNIB (selective internal radiation therapy v sorafenib), an open-label, investigator-initiated, phase III trial, compared yttrium-90 (90 Y) resin microspheres RE with sorafenib 800 mg/d in patients with locally advanced HCC in a two-tailed study designed for superiority/detriment...
March 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29411164/direct-growth-of-iii-nitride-nanowire-based-yellow-light-emitting-diode-on-amorphous-quartz-using-thin-ti-interlayer
#13
Aditya Prabaswara, Jung-Wook Min, Chao Zhao, Bilal Janjua, Daliang Zhang, Abdulrahman M Albadri, Ahmed Y Alyamani, Tien Khee Ng, Boon S Ooi
Consumer electronics have increasingly relied on ultra-thin glass screen due to its transparency, scalability, and cost. In particular, display technology relies on integrating light-emitting diodes with display panel as a source for backlighting. In this study, we undertook the challenge of integrating light emitters onto amorphous quartz by demonstrating the direct growth and fabrication of a III-nitride nanowire-based light-emitting diode. The proof-of-concept device exhibits a low turn-on voltage of 2.6 V, on an amorphous quartz substrate...
February 6, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29408740/responsiveness-of-the-golombok-rust-inventory-of-sexual-satisfaction-in-couples-with-incontinent-partners
#14
Renly Lim, Men Long Liong, Yong Khee Lau, Kah Hay Yuen
OBJECTIVE: In order for a measure to reliably evaluate treatment efficacy, it is important that the measure used has adequate responsiveness. However, the responsiveness of the Golombok Rust Inventory of Sexual Satisfaction (GRISS) questionnaire, a highly recommended questionnaire by the International Consultation of Incontinence to assess sexual function in patients with incontinence, has not been established. To enable the use of GRISS to measure change in sexual function following incontinence treatment, we evaluated the short- and long-term responsiveness of the GRISS in couples with female stress urinary incontinence partners...
March 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29401836/3-2-gigabit-per-second-visible-light-communication-link-with-ingan-gan-mqw-micro-photodetector
#15
Kang-Ting Ho, Rui Chen, Guangyu Liu, Chao Shen, Jorge Holguin-Lerma, Abeer A Al-Saggaf, Tien Khee Ng, Mohamed-Slim Alouini, Jr-Hau He, Boon S Ooi
This paper presents the first demonstration of InGaN multiple quantum well (MQW) based micro-photodetectors (µPD) used as the optical receiver in orthogonal frequency-division multiplexing (OFDM) modulated visible communication system (VLC). The 80-µm diameter µPD exhibits a wavelength-selective responsivity in the near-UV to violet regime (374 nm - 408 nm) under a low reverse bias of -3 V. The modulation scheme of 16-quadrature amplitude modulation (16-QAM) OFDM enables the use of frequency response beyond -3 dB cutoff bandwidth of µPD...
February 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29392885/ex-vivo-expansion-of-cd34-cd90-cd49f-hematopoietic-stem-and-progenitor-cells-from-non-enriched-umbilical-cord-blood-with-azole-compounds
#16
Sudipto Bari, Qixing Zhong, Xiubo Fan, Zhiyong Poon, Alvin Soon Tiong Lim, Tse Hui Lim, Niraja Dighe, Shang Li, Gigi Ngar Chee Chiu, Christina Li Lin Chai, William Ying Khee Hwang
Umbilical cord blood (UCB) transplants in adults have slower hematopoietic recovery compared to bone marrow (BM) or peripheral blood (PB) stem cells mainly due to low number of total nucleated cells and hematopoietic stem and progenitor cells (HSPC). As such in this study, we aimed to perform ex vivo expansion of UCB HSPC from non-enriched mononucleated cells (MNC) using novel azole-based small molecules. Freshly-thawed UCB-MNC were cultured in expansion medium supplemented with small molecules and basal cytokine cocktail...
May 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29388353/clinical-patterns-and-management-of-primary-mucosal-melanoma-a-single-centre-experience
#17
Yvonne Y R Ng, Grace H C Tan, Richard H H Quek, Mohamad B H R Farid, Khee Chee Soo, Melissa C C Teo
BACKGROUND: Primary mucosal melanomas (MM) are rare neoplasms arising from melanocytes in mucosal membranes. Delayed diagnosis and aggressive disease biology contribute to a poorer prognosis. The clinical patterns of MMs treated in a large tertiary centre, and the differences between MMs in the head and neck versus other anatomical sites are described. METHODS: A retrospective review of 43 patients diagnosed with MM in the head and neck, urogenital, esophageal and anorectal sites from 1993 to 2015 was conducted...
February 1, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29381803/capsinoids-activate-brown-adipose-tissue-bat-with-increased-energy-expenditure-associated-with-subthreshold-18-fluorine-fluorodeoxyglucose-uptake-in-bat-positive-humans-confirmed-by-positron-emission-tomography-scan
#18
Lijuan Sun, Stefan G Camps, Hui Jen Goh, Priya Govindharajulu, Joshua D Schaefferkoetter, David W Townsend, Sanjay K Verma, S Sendhil Velan, Lei Sun, Siu Kwan Sze, Su Chi Lim, Bernhard Otto Boehm, Christiani Jeyakumar Henry, Melvin Khee-Shing Leow
Background: Capsinoids are reported to increase energy expenditure (EE) via brown adipose tissue (BAT) stimulation. However, imaging of BAT activation by capsinoids remains limited. Because BAT activation is a potential therapeutic strategy for obesity and related metabolic disorders, we sought to prove that capsinoid-induced BAT activation can be visualized by 18-fluorine fluorodeoxyglucose (18F-FDG) positron emission tomography (PET). Objective: We compared capsinoids and cold exposure on BAT activation and whole-body EE...
January 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29336463/protein-corona-in-drug-delivery-for-multimodal-cancer-therapy-in-vivo
#19
Eugenia Li Ling Yeo, Patricia Soo Ping Thong, Khee Chee Soo, James Chen Yong Kah
The protein corona is inevitably formed on nanoparticles (NPs) when they are introduced in vivo and has been associated with a reduction in targeting yield, immune recognition and rapid blood clearance, leading to poor tumor accumulation. We have recently shown that it is possible to exploit the protein corona for drug delivery by exploiting it for loading and triggering the release of a photosensitizer Chlorin e6 (Ce6) for simultaneous photodynamic (PDT) and photothermal therapy (PTT) in vitro. Here, we extended our previous in vitro studies to evaluate its effectiveness in vivo...
February 1, 2018: Nanoscale
https://www.readbyqxmd.com/read/29328895/what-is-the-hepatitis-b-vaccination-regimen-in-chronic-kidney-disease
#20
Kheng Yong Ong, Hong Yun Wong, Giat Yeng Khee
No abstract text is available yet for this article.
January 2018: Cleveland Clinic Journal of Medicine
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