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https://www.readbyqxmd.com/read/28330940/impact-of-subsidies-on-cancer-genetic-testing-uptake-in-singapore
#1
Shao-Tzu Li, Jeanette Yuen, Ke Zhou, Nur Diana Binte Ishak, Yanni Chen, Marie Met-Domestici, Sock Hoai Chan, Yee Pin Tan, John Carson Allen, Soon Thye Lim, Khee Chee Soo, Joanne Ngeow
PURPOSE: Previous reports cite high costs of clinical cancer genetic testing as main barriers to patient's willingness to test. We report findings of a pilot study that evaluates how different subsidy schemes impact genetic testing uptake and total cost of cancer management. METHODS: We included all patients who attended the Cancer Genetics Service at the National Cancer Centre Singapore (January 2014-May 2016). Two subsidy schemes, the blanket scheme (100% subsidy to all eligible patients), and the varied scheme (patients received 50%-100% subsidy dependent on financial status) were compared...
April 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28320776/epigenomic-promoter-alterations-amplify-gene-isoform-and-immunogenic-diversity-in-gastric-adenocarcinoma
#2
Aditi Qamra, Manjie Xing, Nisha Padmanabhan, Jeffrey Jun Ting Kwok, Shenli Zhang, Xu Chang, Yan Shan Leong, Ai Ping Lee Lim, Qianqao Tang, WenFong Ooi, Joyce Suling Lin, Tannistha Nandi, Xiaosai Yao, Xuewen Ong, Minghui Lee, Su Ting Tay, Angie Tan Lay Keng, Erna Gondo Santoso, Cedric Chuan Young Ng, Alvin Ng, Apinya Jusakul, Duane Smoot, Hassan Ashktorab, Sun Young Rha, Khay Guan Yeoh, Wei Peng Yong, Pierce K H Chow, Weng Hoong Chan, Hock Soo Ong, Khee Chee Soo, Kyoung-Mee Kim, Wai Keong Wong, Steven G Rozen, Bin Tean Teh, Dennis Kappei, Jeeyun Lee, John Connolly, Patrick Tan
Promoter elements play important roles in isoform and cell-type specific expression. We surveyed the epigenomic promoter landscape of gastric adenocarcinoma (GC), analyzing 110 chromatin profiles (H3K4me3, H3K4me1, H3K27ac) of primary GCs, GC lines, and non-malignant gastric tissues. We identified ~2000 promoter alterations (somatic promoters), many deregulated in various epithelial malignancies and mapping frequently to alternative promoters within the same gene, generating potential pro-oncogenic isoforms (RASA3)...
March 20, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28291795/experimental-chronic-kidney-disease-attenuates-ischemia-reperfusion-injury-in-an-ex-vivo-rat-lung-model
#3
Chung-Kan Peng, Kun-Lun Huang, Chou-Chin Lan, Yu-Juei Hsu, Geng-Chin Wu, Chia-Hui Peng, Chin-Pyng Wu, Khee-Siang Chan
Lung ischemia reperfusion injury (LIRI) is one of important complications following lung transplant and cardiopulmonary bypass. Although patients on hemodialysis are still excluded as lung transplant donors because of the possible effects of renal failure on the lungs, increased organ demand has led us to evaluate the influence of chronic kidney disease (CKD) on LIRI. A CKD model was induced by feeding Sprague-Dawley rats an adenine-rich (0.75%) diet for 2, 4 and 6 weeks, and an isolated rat lung in situ model was used to evaluate ischemia reperfusion (IR)-induced acute lung injury...
2017: PloS One
https://www.readbyqxmd.com/read/28222259/band-alignment-at-gan-single-layer-wse2-interface
#4
Malleswararao Tangi, Pawan Mishra, Chien-Chih Tseng, Tien Khee Ng, Mohamed Nejib Hedhili, Dalaver H Anjum, Mohd Sharizal Alias, Nini Wei, Lain-Jong Li, Boon S Ooi
We study the band discontinuity at the GaN/single-layer (SL) WSe2 heterointerface. The GaN thin layer is epitaxially grown by molecular beam epitaxy on chemically vapor deposited SL-WSe2/c-sapphire. We confirm that the WSe2 was formed as an SL from structural and optical analyses using atomic force microscopy, scanning transmission electron microscopy, micro-Raman, absorbance, and microphotoluminescence spectra. The determination of band offset parameters at the GaN/SL-WSe2 heterojunction is obtained by high-resolution X-ray photoelectron spectroscopy, electron affinities, and the electronic bandgap values of SL-WSe2 and GaN...
March 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28177248/surface-passivation-of-gan-nanowires-for-enhanced-photoelectrochemical-water-splitting
#5
Purushothaman Varadhan, Hui-Chun Fu, Davide Priante, Jose Ramon Duran Retamal, Chao Zhao, Mohamed Ebaid, Tien Khee Ng, Idirs Ajia, Somak Mitra, Iman S Roqan, Boon S Ooi, Jr-Hau He
Hydrogen production via photoelectrochemical water-splitting is a key source of clean and sustainable energy. The use of one-dimensional nanostructures as photoelectrodes is desirable for photoelectrochemical water-splitting applications due to the ultralarge surface areas, lateral carrier extraction schemes, and superior light-harvesting capabilities. However, the unavoidable surface states of nanostructured materials create additional charge carrier trapping centers and energy barriers at the semiconductor-electrolyte interface, which severely reduce the solar-to-hydrogen conversion efficiency...
March 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28158020/droop-free-al-sub-x-sub-ga-sub-1-x-sub-n-al-sub-y-sub-ga-sub-1-y-sub-n-quantum-disks-in-nanowires-ultraviolet-led-emitting-at-337-nm-on-metal-silicon-substrates
#6
Bilal Janjua, Haiding Sun, Chao Zhao, Dalaver H Anjum, Davide Priante, Abdullah A Alhamoud, Feng Wu, Xiaohang Li, Abdulrahman M Albadri, Ahmed Y Alyamani, Munir M El-Desouki, Tien Khee Ng, Boon S Ooi
Currently the AlGaN-based ultraviolet (UV) solid-state lighting research suffers from numerous challenges. In particular, low internal quantum efficiency, low extraction efficiency, inefficient doping, large polarization fields, and high dislocation density epitaxy constitute bottlenecks in realizing high power devices. Despite the clear advantage of quantum-confinement nanostructure, it has not been widely utilized in AlGaN-based nanowires. Here we utilize the self-assembled nanowires (NWs) with embedding quantum-disks (Qdisks) to mitigate these issues, and achieve UV emission of 337 nm at 32 A/cm<sup>2</sup> (80 mA in 0...
January 23, 2017: Optics Express
https://www.readbyqxmd.com/read/28138878/preoperative-platelet-lymphocyte-ratio-is-an-independent-prognostic-marker-and-superior-to-carcinoembryonic-antigen-in-colorectal-peritoneal-carcinomatosis-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#7
Tiffany Sin Hui Bong, Grace Hwei Ching Tan, Claramae Chia, Khee Chee Soo, Melissa Ching Ching Teo
OBJECTIVE: The aim of this study was to examine the prognostic significance of preoperative inflammatory-based indices, platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and carcinoembryonic antigen (CEA) in predicting overall survival (OS) in patients with colorectal peritoneal carcinomatosis (CPC) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: Sixty patients with pathologically confirmed CPC treated with CRS and HIPEC between 2003 and 2015 were included...
January 30, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28094849/the-collimator-monitoring-fill-factor-of-a-two-dimensional-detector-array-a-measure-of-its-ability-to-detect-collimation-errors
#8
Tenzin Sonam Stelljes, Hui Khee Looe, Dietrich Harder, Björn Poppe
PURPOSE: Two-dimensional detector arrays are routinely used for constancy checks and treatment plan verification in photon-beam radiotherapy. In addition to the spatial resolution of the dose profiles, the "coverage" of the radiation field with respect to the detection of any beam collimation deficiency appears as the second characteristic feature of a detector array. The here proposed "collimator monitoring fill factor" (CM fill factor) has been conceived to serve as a quantitative characteristic of this "coverage"...
January 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28093718/ribosomal-protein-s3-gene-silencing-protects-against-experimental-allergic-asthma
#9
Jinrui Dong, Wupeng Liao, Hong Yong Peh, Tze Khee Chan, W S Daniel Tan, Li Li, Amy Yong, W S Fred Wong
BACKGROUND AND PURPOSE: Ribosomal protein S3 (RPS3) is a 40S ribosomal protein of the S3P family essential for implementing protein translation. RPS3 has recently been found to interact with the p65 subunit of the NF-κB complex and promote p65 DNA-binding activity. Persistent activation of the NF-κB pathway is evident in allergic asthma. We hypothesized that gene silencing of lung RPS3 can ameliorate allergic airway inflammation. EXPERIMENTAL APPROACH: The gene silencing efficacy of RPS3 siRNA was screened in three different mouse cell lines by real-time PCR and immunoblotting...
April 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28065414/high-level-ambient-particulate-matter-before-influenza-attack-with-increased-incidence-of-aspergillus-antigenemia-in-southern-taiwan-2016
#10
Wen-Liang Yu, Wei-Lun Liu, Khee-Siang Chan, Chun-Chieh Yang, Che-Kim Tan, Chi-Lun Tsai, Chin-Ming Chen, Yin-Ching Chuang
We found significant correlation between the incidence of severe influenza and Aspergillus antigenemia among medical intensive care unit patients for 7-month observation (coefficient γ=0.976, p<0.001). High-level ambient pollution was noticed for 2 months before the epidemic, highlighting that influenza patients might coinfect with aspergillosis in the community.
December 18, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28039012/personalized-glucose-insulin-model-based-on-signal-analysis
#11
Simon L Goede, Bastiaan E de Galan, Melvin Khee Shing Leow
Glucose plasma measurements for diabetes patients are generally presented as a glucose concentration-time profile with 15-60min time scale intervals. This limited resolution obscures detailed dynamic events of glucose appearance and metabolism. Measurement intervals of 15min or more could contribute to imperfections in present diabetes treatment. High resolution data from mixed meal tolerance tests (MMTT) for 24 type 1 and type 2 diabetes patients were used in our present modeling. We introduce a model based on the physiological properties of transport, storage and utilization...
December 28, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28035037/evaluation-of-a-care-transition-program-with-pharmacist-provided-home-based-medication-review-for-elderly-singaporeans-at-high-risk-of-readmissions
#12
McVin Hua Heng Cheen, Chong Ping Goon, Wan Chee Ong, Paik Shia Lim, Choon Nam Wan, Mei Yan Leong, Giat Yeng Khee
OBJECTIVE: This study aimed to determine whether pharmacist-provided home-based medication review (HBMR) can reduce readmissions in the elderly. DESIGN: Retrospective cohort study. SETTING: Patient's home. PARTICIPANTS: Records of patients referred to a care transition program from March 2011 through March 2015 were reviewed. Patients aged 60 years and older taking more than 5 medications and had at least 2 unplanned admissions within 3 months preceding the first home visit were included...
December 29, 2016: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/27992384/the-energy-dependence-of-the-lateral-dose-response-functions-of-detectors-with-various-densities-in-photon-beam-dosimetry
#13
Hui Khee Looe, Dietrich Harder, Björn Poppe
The lateral dose response function is a general characteristic of the volume effect of a detector used for photon dosimetry in a water phantom. It serves as the convolution kernel transforming the true absorbed dose to water profile, which would be produced within the undisturbed water phantom, into the detector-measured signal profile. The shape of the lateral dose response function characterizes (i) the volume averaging attributable to the detector's size and (ii) the disturbance of the secondary electron field associated with the deviation of the electron density of the detector material from the surrounding water...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27979608/early-mobilization-reduces-duration-of-mechanical-ventilation-and-intensive-care-unit-stay-in-patients-with-acute-respiratory-failure
#14
Chih-Cheng Lai, Willy Chou, Khee-Siang Chan, Kuo-Chen Cheng, Kuo-Shu Yuan, Chien-Ming Chao, Chin-Ming Chen
OBJECTIVE: To evaluate the effects of a quality improvement program to introduce early mobilization on the outcomes of patients with mechanical ventilation (MV) in the intensive care unit (ICU). DESIGN: A retrospective observational study. SETTING: Nineteen-bed ICU at a medical center. PARTICIPANTS: Adults patients with MV (N=153) admitted to a medical ICU. INTERVENTIONS: A multidisciplinary team (critical care nurse, nursing assistant, respiratory therapist, physical therapist, patient's family) initiated the protocol within 72 hours of MV when patients become hemodynamically stable...
December 13, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27902388/the-exploration-of-risk-factors-of-concurrent-bacteraemia-in-patients-critically-ill-with-severe-dengue
#15
Chin-Ming Chen, Khee-Siang Chan, Kuo-Chen Cheng, Willy Chou, Hui-Chun Chao, Chiu-Yin Yeh, Wen-Liang Yu
We investigated the clinical features of intensive care unit (ICU) patients with concomitant severe dengue infection and bacteraemia to identify risk factors for this comorbidity. The records of all ICU dengue patients admitted during the period of 31 July-30 November 2015 were reviewed. Patients with 'concurrent bacteremia' (positive bacterial blood culture within 72 h of ICU admission) were identified. ICU admission was required for 142 patients, of which 22 (15.5 %) had concurrent bacteraemia. Species of the genus Streptococcus was the most common pathogens, followed by Escherichia coli then species of the genus Staphylococcus...
December 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27879037/nanomembrane-based-thermal-transport-biosensor-for-living-cells
#16
Rami T ElAfandy, Ayman F AbuElela, Pawan Mishra, Bilal Janjua, Hassan M Oubei, Ulrich Büttner, Mohammed A Majid, Tien Khee Ng, Jasmeen S Merzaban, Boon S Ooi
Knowledge of materials' thermal-transport properties, conductivity and diffusivity, is crucial for several applications within areas of biology, material science and engineering. Specifically, a microsized, flexible, biologically integrated thermal transport sensor is beneficial to a plethora of applications, ranging across plants physiological ecology and thermal imaging and treatment of cancerous cells, to thermal dissipation in flexible semiconductors and thermoelectrics. Living cells pose extra challenges, due to their small volumes and irregular curvilinear shapes...
November 23, 2016: Small
https://www.readbyqxmd.com/read/27869363/is-the-memorial-sloan-kettering-cancer-centre-mskcc-sarcoma-nomogram-useful-in-an-asian-population
#17
Deanna Wan Jie Ng, Grace Hwei Ching Tan, Claramae Shulyn Chia, Cindy Xindi Lim, Soo Khee Chee, Richard Hong Hui Quek, Mohamad Farid, Melissa Ching Ching Teo
AIM: A nomogram for prediction of 12-year sarcoma-specific survival has been developed based on patients with soft tissue sarcomas treated in Memorial Sloan Kettering Cancer Centre (MSKCC). We aim to evaluate the predictive accuracy of the MSKCC sarcoma nomogram in a cohort of patients treated at an Asian institution. This has not been validated in an Asian population and thus its universal applicability remains unproven. MATERIALS AND METHODS: Between 1990 and 2013, 840 adult patients underwent treatment for primary soft tissue sarcoma (STS) at the National Cancer Centre Singapore...
November 21, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27866377/unusual-cause-of-hypercalcaemia-in-end-stage-renal-failure-patients
#18
Hooi Khee Teo, Jiunn Wong
Immobility-induced hypercalcaemia is rarely considered in patients on dialysis and is a challenging diagnosis to make. This is especially so due to the lack of biomarkers as well as the notion that calcium metabolism is mostly related to chronic kidney disease-metabolic bone disorder due to the role of iPTH. We present two cases of our dialysis patients, who were clinically unwell from hypercalcemia. We were initially uncertain of the cause of hypercalcemia as despite our attempts to adjust treatment based on their biochemical findings, we were unable to correct the hypercalcemia...
November 20, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27855557/201-consecutive-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-procedures-in-a-single-asian-tertiary-centre
#19
Grace Tan, Claramae Chia, Mrinal Kumar, Su Pin Choo, John Chia, Chee Kian Tham, Clarinda Chua, Khee Chee Soo, Melissa Teo
INTRODUCTION: Peritoneal carcinomatosis (PC) is increasingly being treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). We provide a review of a high-volume Asian institute's experience and survival outcomes with this procedure. METHODS: Data were prospectively collected from 201 consecutive CRS and HIPEC procedures performed in a single institution between April 2001 and November 2015. Our primary endpoints were overall survival (OS) and disease-free survival (DFS), and secondary endpoints were morbidity and mortality...
December 14, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27832924/nasopharyngectomy-with-operating-microscope-a-case-series
#20
Jia Hui Jang, Hiang Khoon Tan, N Gopalakrishna Iyer, Khee Chee Soo, Ngian Chye Tan
BACKGROUND: Nasopharyngectomy for excision of nasopharyngeal tumors is challenging, as access to the nasopharynx is difficult. Recently our institution embarked on two new approaches - robotic nasopharyngectomy and open nasopharyngectomy with operating microscope (NOM) via maxillary swing approach. This article proposes that the novel approach of NOM via maxillary swing aids visualization for resection of locally invasive nasopharyngeal tumors. METHODS: Over a thirteen-month period, eight patients required nasopharyngectomy in our single Asian institution...
January 2017: American Journal of Otolaryngology
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