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JOURNAL ARTICLE
Li Chen, Xue Ping Goh, Anne K Bendt, Karen Mei-Ling Tan, Melvin Khee-Shing Leow, Kok Hian Tan, Jerry K Y Chan, Shiao-Yng Chan, Yap Seng Chong, Peter D Gluckman, Johan G Eriksson, Markus R Wenk, Sartaj Ahmad Mir
CONTEXT: Due to the essential role of carnitine as an intermediary in amino acid, carbohydrate and lipid metabolism, a detailed characterization of circulating and urinary carnitine concentrations will aid in elucidating the molecular basis of impaired maternal metabolic flexibility and facilitating timely intervention for expectant mothers. OBJECTIVE: To investigate the association of maternal plasma and urinary free carnitine and acylcarnitines with cardiometabolic risk factors...
April 16, 2024: Journal of Clinical Endocrinology and Metabolism
#2
JOURNAL ARTICLE
Chin Jin Seo, Joey Wee-Shan Tan, Mohamad Farid, Jolene Si Min Wong, Khee Chee Soo, Claramae Shulyn Chia, Chin-Ann Johnny Ong
BACKGROUND: Peritoneal sarcomatosis (PS) is a difficult entity to treat with limited options and guarded prognosis. We aimed to determine if the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) could offer superior local recurrence-free survival in patients with retroperitoneal sarcoma at high risk of developing PS as opposed to extended resection alone. METHODS: This is a single arm, phase II intervention study where all patients with recurrent localized retroperitoneal sarcoma considered at high risk of developing PS were considered for enrolment (ClinicalTrials...
2024: PloS One
#3
EDITORIAL
Lorenzo Patrone, Edoardo Pasqui, Michael S Conte, Alik Farber, Roberto Ferraresi, Matthew Menard, Joseph L Mills, John Rundback, Peter Schneider, August Ysa, Kumar Abhishek, George L Adams, Naseer Ahmad, Irfan Ahmed, Vlad A Alexandrescu, Max Amor, David Alper, Martin Andrassy, Christopher Attinger, Andy Baadh, Hashem Barakat, Lukla Biasi, Theodosios Bisdas, Zagum Bhatti, Erwin Blessing, Marc P Bonaca, Stefano Bonvini, Michel Bosiers, Andrew W Bradbury, Robert Beasley, Christian-Alexander Behrendt, Marianne Brodmann, Gonzalo Cabral, Roberto Cancellieri, Andrea Casini, Venita Chandra, Emiliano Chisci, Omar Chohan, Edward T C Choke, Patrick F S Chong, Giacomo Clerici, Raphael Coscas, Mary Costantino, Luca Dalla Paola, Sabeen Dand, Robert S M Davies, Mario D'Oria, Athanasios Diamantopoulos, Sebastian Debus, Koen Deloose, Costantino Del Giudice, Gianmarco de Donato, Brian De Rubertis, Jean Paul De Vries, Nuno V Dias, Larry Diaz-Sandoval, Florian Dick, Konstantinos Donas, Anahita Dua, Fabrizio Fanelli, Stefano Fazzini, Mazin Foteh, Roberto Gandini, Mauro Gargiulo, Luca Garriboli, Elizabeth A Genovese, Edward Gifford, Yann Goueffic, Peter Goverde, Prem Chand Gupta, Robert Hinchliffe, Andrew Holden, Kim C Houlind, Dominic Pj Howard, Bella Huasen, Giacomo Isernia, Konstantinos Katsanos, Barry Katzen, Philippe Kolh, Igor Koncar, Grigorios Korosoglou, Prakash Krishnan, Thomas Kroencke, Miltiadis Krokidis, Arun Kumarasamy, Paul Hayes, Osamu Iida, Enrique Alejandre Lafont, Ralf Langhoff, Alexandre Lecis, Mark Lessne, Hady Lichaa, Michael Lichtenberg, Marta Lobato, Alice Lopes, Giorgio Loreni, Pierleone Lucatelli, Sreekumar Madassery, Lieven Maene, Marco Manzi, Martin Maresch, Jay Santhosh Mathews, James McCaslin, Antonio Micari, Stefano Michelagnoli, Bruno Migliara, Robert Morgan, Luis Morelli, Daniele Morosetti, Nicolas Mouawad, Paul Moxey, Stefan Müller-Hülsbeck, Jihad Mustapha, Tatsuya Nakama, Bahaa Nasr, Zola N'dandu, Richard Neville, Elias Noory, Joakim Nordanstig, Katariina Noronen, Luis Mariano Palena, Gianbattista Parlani, Ashish S Patel, Parag Patel, Rafiuddin Patel, Sanjay Patel, Costantino Pena, Drazen Perkov, Mark Portou, Giovanni Pratesi, Christos Rammos, Jim Reekers, Vicente Riambau, Trisha Roy, Kenneth Rosenfield, Maria Antonella Ruffino, Fadi Saab, Athanasios Saratzis, Paolo Sbarzaglia, Andrej Schmidt, Eric Secemsky, Michael Siah, Henrik Sillesen, Gioele Simonte, Marc Sirvent, Jill Sommerset, Sabine Steiner, Ahmed Sakr, Dierk Scheinert, Mehdi Shishebor, Stavros Spiliopoulos, Alessio Spinelli, Konstantinos Stravoulakis, Gergana Taneva, Desarom Teso, Joerg Tessarek, Selva Theivacumar, Anish Thomas, Shannon Thomas, Narayan Thulasidasan, Giovanni Torsello, Ramesh Tripathi, Nicola Troisi, Srini Tummala, Venkat Tummala, Christopher Twine, Raman Uberoi, Alessandro Ucci, Domenico Valenti, Jos van den Berg, Daniel van den Heuvel, Isabelle Van Herzeele, Ramon Varcoe, Melina Vega de Ceniga, Frank J Veith, Maarit Venermo, Badri Vijaynagar, Sanjiv Virdee, Conrad Von Stempel, Michiel T Voûte, Kak Khee Yeung, Thomas Zeller, Hany Zayed, Miguel Montero Baker
No abstract text is available yet for this article.
March 25, 2024: Journal of Endovascular Therapy
#4
JOURNAL ARTICLE
Shasha Han, Joel Goh, Fanwen Meng, Melvin Khee-Shing Leow, Donald B Rubin
Existing methods that use propensity scores for heterogeneous treatment effect estimation on non-experimental data do not readily extend to the case of more than two treatment options. In this work, we develop a new propensity score-based method for heterogeneous treatment effect estimation when there are three or more treatment options, and prove that it generates unbiased estimates. We demonstrate our method on a real patient registry of patients in Singapore with diabetic dyslipidemia. On this dataset, our method generates heterogeneous treatment recommendations for patients among three options: Statins, fibrates, and non-pharmacological treatment to control patients' lipid ratios (total cholesterol divided by high-density lipoprotein level)...
March 18, 2024: Statistical Methods in Medical Research
#5
JOURNAL ARTICLE
Xin Zhu, Yue Wang, Issatay Nadinov, Simil Thomas, Luis Gutiérrez-Arzaluz, Tengyue He, Jian-Xin Wang, Omar Alkhazragi, Tien Khee Ng, Osman M Bakr, Husam N Alshareef, Boon S Ooi, Omar F Mohammed
Intermolecular charge transfer (CT) complexes have emerged as versatile platforms with customizable optical properties that play a pivotal role in achieving tunable photoresponsive materials. In this study, we introduce an innovative approach for enhancing the modulation bandwidth and net data rates in optical wireless communications (OWCs) by manipulating combinations of monomeric molecules within intermolecular CT complexes. Concurrently, we extensively investigate the intermolecular charge transfer mechanism through diverse steady-state and ultrafast time-resolved spectral techniques in the mid-infrared range complemented by theoretical calculations using density functional theory...
March 8, 2024: Journal of Physical Chemistry Letters
#6
JOURNAL ARTICLE
Isabel Blum, Jing Syuen Wong, Krishna Godino Padre, Jessica Stolzenberg, Hermann Fuchs, Kilian-Simon Baumann, Bjoern Poppe, Hui Khee Looe
OBJECTIVE: The aim of this work is to investigate the response of the Roos chamber (type 34001) irradiated by clinical proton beams in magnetic fields. APPROACH: At first, a Fano test was implemented in Monte Carlo software package GATE version 9.2 (based on Geant4 version 11.0.2) using a cylindrical slab geometry in a magnetic field up to 1 T. In accordance to an experimental setup (Fuchs et al 2021), the magnetic field correction factors kB Q of the Roos chamber were determined at different energies up to 252 MeV and magnetic field strengths up to 1 T, by separately simulating the ratios of chamber signals MQ /MB Q , without and with magnetic field, and the dose-conversion factors DB w,Q /Dw,Q in a small cylinder of water, with and without magnetic field...
March 7, 2024: Physics in Medicine and Biology
#7
REVIEW
Mohamad Adam Bujang, Evi Diana Omar, Diana Hui Ping Foo, Yoon Khee Hon
This article is a narrative review that discusses the recommended sample size requirements to design a pilot study to assess the reliability of a questionnaire. A list of various sample size tables that are based on the kappa agreement test, intra-class correlation test and Cronbach's alpha test has been compiled together. For all calculations, type I error (alpha) was set at a maximum value of 0.05, and power was set at a minimum value of 80.0%. For the kappa agreement test, intra-class correlation test, and Cronbach's alpha test, the recommended minimum sample size requirement based on the ideal effect sizes shall be at least 15, 22, and 24 subjects respectively...
February 2024: Restorative Dentistry & Endodontics
#8
REVIEW
Jia Zheng Leong, Yew Hin Beh, Ting Khee Ho
The goal of prosthodontics is to provide a functional prosthesis to restore aesthetics, functions, and masticatory efficiencies. Tooth-supported overdentures are one of the treatment options for removable dentures. This article aims to discuss the advantages and disadvantages of tooth-supported overdentures and the principles of using various overdenture attachments, including non-attachment overdentures. The common treatment options in preparing the overdenture abutment are either with or without abutment coping with or without attachment systems, which were discussed and illustrated...
January 2024: Curēus
#9
JOURNAL ARTICLE
Petar Zlatanovic, Lazar Davidovic, Daniele Mascia, Stefano Ancetti, Kak Khee Yeung, Vincent Jongkind, Herman Vitala, Maarit Venermo, Arno Wiersema, Roberto Chiesa, Mauro Gargiulo
INTRODUCTION: The aim of this cohort study was to report the proportion of patients who develop periprocedural acute kidney injury (AKI) after endovascular repair (ER) and open surgery (OS) in patients with juxta/pararenal abdominal aortic aneurysm (JAAA/PAAA) and to assess potential risk factors for AKI. The study also aimed to report the short- and long-term outcomes of patients with and without AKI. MATERIALS AND METHODS: This was a multicenter cohort study of five European academic high volume centres (more than 50 open or 50 endovascular infrarenal AAA repairs, plus more than 15 complex AAA repairs per year)...
February 21, 2024: Journal of Vascular Surgery
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JOURNAL ARTICLE
Giat Yeng Khee, Paik Shia Lim, Yoke Ling Chan, Phong Ching Lee
Background: A collaborative prescribing (CP) practice model, established by the endocrinologists, pharmacists, and advanced practice nurses, aims to provide for the postoperative monitoring and medical and nutritional management of stable patients after bariatric surgery. Method: Under the CP agreement, endocrinologists refer patients who have undergone bariatric surgery with stable medical conditions to CP practitioners, comprising senior pharmacists and advanced practice nurses. CP practitioners review the patient's weight loss progress, blood test results and vitals, the sufficiency of micronutrient repletion, adherence to supplements and medications, and chronic disease control...
February 8, 2024: Pharmacy (Basel, Switzerland)
#11
JOURNAL ARTICLE
Wai Har Ng, Khee Chee Soo, Hung Huynh
Hepatocellular carcinoma (HCC) is a leading global cause of cancer-related mortality. Despite the widespread adoption of sorafenib as the standard HCC treatment, its efficacy is constrained, frequently encountering resistance. To augment the effectiveness of sorafenib, this study investigated the synergy of sorafenib and vinorelbine using 22 HCC patient-derived xenograft (PDX) models. In this study, mice bearing HCC tumors were treated with the vehicle, sorafenib (15 mg/kg), vinorelbine (3 mg/kg), and sorafenib-vinorelbine combination (Sora/Vino)...
January 26, 2024: International Journal of Molecular Sciences
#12
JOURNAL ARTICLE
Wann Jia Loh, Jadegoud Yaligar, Amanda J Hooper, Suresh Anand Sadananthan, Yeshe Kway, Su Chi Lim, Gerald F Watts, Sambasivam Sendhil Velan, Melvin Khee Shing Leow, Joan Khoo
BACKGROUND: Familial partial lipodystrophy (FPLD) is an inherited disorder of white adipose tissue that causes premature cardiometabolic disease. There is no clear diagnostic criteria for FPLD, and this may explain the under-detection of this condition. AIM: This pilot study aimed to describe the clinical features of women with FPLD and to explore the value of adipose tissue measurements that could be useful in diagnosis. METHODS: In 8 women with FPLD and 4 controls, skinfold measurements, DXA and whole-body MRI were undertaken...
February 6, 2024: Nutrition & Diabetes
#13
JOURNAL ARTICLE
Anders Wanhainen, Isabelle Van Herzeele, Frederico Bastos Goncalves, Sergi Bellmunt Montoya, Xavier Berard, Jonathan R Boyle, Mario D'Oria, Carlota F Prendes, Christos D Karkos, Arkadiusz Kazimierczak, Mark J W Koelemay, Tilo Kölbel, Kevin Mani, Germano Melissano, Janet T Powell, Santi Trimarchi, Nikolaos Tsilimparis, George A Antoniou, Martin Björck, Raphael Coscas, Nuno V Dias, Philippe Kolh, Sandro Lepidi, Barend M E Mees, Timothy A Resch, Jean Baptiste Ricco, Riikka Tulamo, Christopher P Twine, Daniela Branzan, Stephen W K Cheng, Ronald L Dalman, Florian Dick, Jonathan Golledge, Stephan Haulon, Joost A van Herwaarden, Nikola S Ilic, Arkadiusz Jawien, Tara M Mastracci, Gustavo S Oderich, Fabio Verzini, Kak Khee Yeung
OBJECTIVE: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with aneurysms of the abdominal aorta and iliac arteries in succession to the 2011 and 2019 versions, with the aim of assisting physicians and patients in selecting the best management strategy. METHODS: The guideline is based on scientific evidence completed with expert opinion on the matter. By summarising and evaluating the best available evidence, recommendations for the evaluation and treatment of patients have been formulated...
February 2024: European Journal of Vascular and Endovascular Surgery
#14
JOURNAL ARTICLE
Leonard Tang, Tong Khee Tan
This article summarises the key anaesthetic considerations and challenges surrounding the perioperative management of a patient undergoing awake craniotomy. The main goals include patient comfort, facilitation of patient cooperation during the critical awake phase and maintenance of optimal operating conditions. These are achieved through appropriate patient selection and preparation, familiarity with the complexity of each surgical phase and potential complications that may arise, as well as maintenance of close communication among all team members...
February 2, 2024: Singapore Medical Journal
#15
JOURNAL ARTICLE
Carmen Yap, Shaynah Wanga, Rob C I Wüst, Bram W van Os, Maud M E Pijls, Sofie Keijzer, Eva van Zanten, David R Koolbergen, Antoine H G Driessen, Ron Balm, Kak Khee Yeung, Carlie J M de Vries, Riekelt H Houtkooper, Jan H N Lindeman, Vivian de Waard
The antibiotic doxycycline is known to inhibit inflammation and was therefore considered as a therapeutic to prevent abdominal aortic aneurysm (AAA) growth. Yet mitochondrial dysfunction is a key-characteristic of clinical AAA disease. We hypothesize that doxycycline impairs mitochondrial function in the aorta and aortic smooth muscle cells (SMCs). Doxycycline induced mitonuclear imbalance, reduced proliferation and diminished expression of typical contractile smooth muscle cell (SMC) proteins. To understand the underlying mechanism, we studied krüppel-like factor 4 (KLF4)...
January 23, 2024: Vascular Pharmacology
#16
JOURNAL ARTICLE
Nanxi Huang, Qiaochu Wang, Robert B Bernard, Chao-Yang Chen, Je-Ming Hu, Jehng-Kang Wang, Khee-Siang Chan, Michael D Johnson, Chen-Yong Lin
Mutations in the Kunitz-type serine protease inhibitor HAI-2, encoded by SPINT2, are responsible for the pathogenesis of syndromic congenital sodium diarrhea (SCSD), an intractable secretory diarrhea of infancy. Some of the mutations cause defects in the functionally required Kunitz domain 1 and/or subcellular targeting signals. Almost all SCSD patients, however, harbor SPINT2 missense mutations that affect the functionally less important Kunitz domain 2. How theses single amino acid substitutions inactivate HAI-2 was, here, investigated by the doxycycline-inducible expression of three of these mutants in HAI-2-knockout Caco-2 human colorectal adenocarcinoma cells...
January 25, 2024: Human Molecular Genetics
#17
JOURNAL ARTICLE
Hung Huynh, Wai Har Ng, Khee Chee Soo
Hepatocellular carcinoma (HCC) is a challenging cancer to treat, as traditional chemotherapies have shown limited effectiveness. The mammalian target of rapamycin/sirolimus (mTOR) and microtubules are prominent druggable targets for HCC. In this study, we demonstrated that co-targeting mTOR using mTOR inhibitors (everolimus and sirolimus) along with the microtubule inhibitor vinorelbine yielded results superior to those of the monotherapies in HCC PDX models. Our research showed that the vinorelbine arrests cells at the mitotic phase, induces apoptosis, and normalizes tumor blood vessels but upregulates survivin and activates the mTOR/p70S6K/4EBP1 pathway...
December 19, 2023: International Journal of Molecular Sciences
#18
JOURNAL ARTICLE
Mohamad Adam Bujang, Wei Hong Lai, Yoon Khee Hon, Eileen Pin Pin Yap, Xun Ting Tiong, Selvasingam Ratnasingam, Alex Ren Jye Kim, Masliyana Husin, Yvonne Yih Huan Jee, Nurul Fatma Diyana Ahmad, Jamaiyah Haniff
Quality of life (QOL) should ideally be determined by a broader spectrum of measurable parameters. This study aims to develop and validate a study instrument that is designed to determine a holistic measure of health and non-health aspects of QOL, and it is called the 'Significant Quality of Life Measure' (SigQOLM). This study involves five phases which aim to (i) explore and understand the subject matter content, (ii) develop a questionnaire, (iii) assess its content validity and face validity, (iv) conduct a pilot study, and lastly (v) perform a field-test by using the questionnaire...
December 2023: Heliyon
#19
JOURNAL ARTICLE
Thirrisha Murugan, Louis Choon Kit Wong, Xing-Yi Sarah Ong, Sze Huey Tan, Joey Wee-Shan Tan, Ying Liu, Nicholas B Shannon, Jianbang Chiang, Eileen Poon, Jason Yongsheng Chan, Valerie Shiwen Yang, Nagavalli Somasundaram, Mohamad Farid, Ru Xin Wong, Wen Long Nei, Jin Wei Kwek, Choon Hua Thng, Tiffany Hennedige, Po Yin Tang, Sathiyamoorthy Selvarajan, Kae Jack Tay, Mohamed Rezal Abdul, Jolene Si Min Wong, Chin Jin Seo, Khee Chee Soo, Claramae Shulyn Chia, Chin-Ann Johnny Ong
OBJECTIVE: To examine the association between the performance of mapping biopsies and surgical outcomes postexcision of extramammary Paget's disease (EMPD). BACKGROUND: Primary EMPD is a rare entity associated with poorly defined surgical margins and difficult-to-access sites of lesions. Surgical resection with clear margins remains the preferred management method. The use of mapping biopsies might be beneficial, particularly in lowering disease recurrence. METHODS: Available literature was reviewed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology before a fixed-effect meta-analysis was performed to identify the presence of a correlation between performing mapping biopsies and positive margins on permanent sections as well as disease-free survival...
December 2023: Annals of surgery open: perspectives of surgical history, education, and clinical approaches
#20
JOURNAL ARTICLE
Nawal Almaymoni, Omar Alkhazragi, Chun Hong Kang, Georgian Melinte, Tien Khee Ng, Boon S Ooi
Vertical-cavity surface-emitting lasers (VCSELs) are widely used as light sources for high-speed communications. This is mainly due to their economical cost, high bandwidth, and scalability. However, efficient red VCSELs with emissions at 650 nm are required for plastic optical fiber (POF) technology because of the low-loss transmission window centered around this wavelength. This study investigates using 650-nm red VCSEL arrays in interconnected systems for POF communication to improve signal quality and increase data rates...
December 4, 2023: Optics Express
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