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Minimally invasive preparation

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https://www.readbyqxmd.com/read/29221285/robot-assisted-thoracic-surgery-for-complex-procedures
#1
Shuenn-Wen Kuo, Pei-Ming Huang, Mong-Wei Lin, Ke-Cheng Chen, Jang-Ming Lee
Background: As an option for minimally invasive thoracic surgery, robot-assisted thoracic surgery (RATS) has shown comparable perioperative outcomes to those achieved by traditional video-assisted thoracic surgery (VATS). It is unknown whether RATS might have any potential benefits in more complex thoracic surgical procedures, which usually require open surgery instead of VATS. The current study presents a preliminary result regarding the use of RATS in complex thoracic operations in an attempt to address this unresolved question...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29218581/fabrication-of-tip-dissolving-microneedles-for-transdermal-drug-delivery-of-meloxicam
#2
Jianmin Chen, Weiyue Huang, Ziyao Huang, Shiqi Liu, Yaling Ye, Qinglian Li, Meiping Huang
Dissolving microneedles (MNs) offered a simple, minimally invasive method for meloxicam (MX) delivery to the skin. However, the fabrication of dissolving MNs still faced some challenges, such as significant time consumption, loss of drug activity, and difficulty in regulating MN drug loading. To address these issues, we developed the tip-dissolving (TD) MNs. Several kinds of drugs were encapsulated successfully, and the quantity of MX ranged from 37.23 ± 8.40 to 332.53 ± 13.37 μg was precisely controlled...
December 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29217972/clinical-aspects-and-antenatal-diagnosis-of-invasive-placenta-a-review-of-ten-years-experience-of-a-multi-profile-hospital-in-lithuania
#3
Jelena Volochovič, Diana Ramašauskaitė, Ramunė Šimkevičiūtė
Background: Invasive placenta is a rare obstetrical pathology that is life-threatening to mother and child. It is important to diagnose this pathology as early as possible and to plan further optimal care of patients in order to minimize life-threatening complications. The aim of this study was to analyze the frequency of cases of invasive placenta, the peculiarities of their clinical manifestation in women who gave birth from 2006 to 2015, to evaluate diagnostic and treatment options of this pathology, and to review their changes when the level of services provided by the institution changes...
2017: Acta medica Lituanica
https://www.readbyqxmd.com/read/29216869/horizontal-ridge-reconstruction-of-the-anterior-maxilla-using-customized-allogeneic-bone-blocks-with-a-minimally-invasive-technique-a-case-series
#4
Laurent Venet, Michel Perriat, Francesco Guido Mangano, Thomas Fortin
BACKGROUND: Different surgical procedures have been proposed to achieve horizontal ridge reconstruction of the anterior maxilla; all these procedures, however, require bone replacement materials to be adapted to the bone defect at the time of implantation, resulting in complex and time-consuming procedures. The purpose of this study was to describe how to use a 3D printed hardcopy model of the maxilla to prepare customized milled bone blocks, to be adapted on the bone defect areas using a minimally invasive subperiosteal tunneling technique...
December 8, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29216752/an-acryl-resin-based-swellable-microneedles-for-controlled-release-intradermal-delivery-of-granisetron
#5
Guozhong Yang, Meilin He, Suohui Zhang, Man Wu, Yunhua Gao
Swellable microneedles (SMNs) are made of hydrogels and can deliver drug with controlled delivery rate by the cross-link density of the hydrogel. In this study, an acryl resin-based SMNs was developed for poorly water-soluble drugs. The making process of the SMNs is very simple and only need 60 min. The SMNs has high mechanical strength and is not easily broken. In-vitro release of SMNs-loaded model drug, granisetron base (GRB), was investigated. The results showed that 7 days controlled release of GRB was obtained when SMNs contained pore-foaming agents (1...
December 8, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29214376/polymer-infiltrated-ceramic-cad-cam-inlays-and-partial-coverage-restorations-3-year-results-of-a-prospective-clinical-study-over-5-years
#6
F A Spitznagel, K J Scholz, J R Strub, K Vach, P C Gierthmuehlen
OBJECTIVE: The aim of this prospective clinical 5-year study was to evaluate the long-term behavior of monolithic computer-aided design and computer-aided manufacturing (CAD/CAM)-fabricated minimally invasive polymer-infiltrated ceramic network (PICN) inlays and partial coverage restorations (PCR). MATERIAL AND METHODS: Posterior teeth of 47 patients were restored with 103 restorations (45 inlays, 58 PCRs). After defect-oriented preparations, monolithic PICN restorations of VITA Enamic were fabricated with a CAD/CAM system (inEoS blue/CEREC inLab MCXL) and adhesively bonded (Variolink II)...
December 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29203310/rosiglitazone-infusion-therapy-following-minimally-invasive-surgery-for-ich-evacuation-decreased-perihematomal-glutamate-content-as-well-as-bbb-permeability-in-rabbits
#7
Guofeng Wu, Yu Jiao, Junjie Wu, Riying Ren, Likun Wang, Zhouping Tang, Houguang Zhou
OBJECTIVES: To observe the effects of Rosiglitazone infusion therapy on perihematomal PPARγ, glutamate level, BBB permeability and brain edema. METHODS: A total of 50 male rabbits (2.8-3.4 kg) were randomly assigned to a normal control group (NC group), a model control group (MC group), a Rosiglitazone group (RSG group), a minimally invasive surgery group (MIS group) or a MIS combined with Rosiglitazone group (MIS+RSG group). An ICH was induced in all the animals, except for the NC group...
December 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29203261/preoperative-computed-tomography-guided-pulmonary-lesion-marking-in-preparation-for-fluoroscopic-wedge-resection-rates-of-success-complications-and-pathology-outcomes
#8
Babatunde Olaiya, Charles A Gilliland, Seth D Force, Felix G Fernandez, Manu S Sancheti, William C Small
PURPOSE: In this study, we describe our experience of lesion marking with fiducial markers (FM) and microcoils (MC) facilitating same-day surgical wedge resection, including success rates, pathology outcomes, and complications. We also explored patient/nodular characteristics associated with developing complications. MATERIALS AND METHODS: An IRB-approved single-institutional retrospective study of 136 patients who had 148 pulmonary nodules was conducted. All patients had CT-guided pulmonary nodule labeling with either FM (121) or MC (15) patients with plan for same-day fluoroscopic-guided wedge resection...
November 6, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29192597/circulating-tumour-dna-analytical-aspects-and-clinical-applications-for-metastatic-melanoma-patients
#9
Guillaume Herbreteau, Audrey Vallée, Anne-Chantal Knol, Sandrine Théoleyre, Gaëlle Quéreux, Amir Khammari, Brigitte Dréno, Marc G Denis
The management of metastatic melanoma has evolved since the onset of treatments with BRAF inhibitors. In order to predict which patients are likely to respond to these treatments, the therapeutic strategy is now conditioned by the search for the activating mutations of the BRAF gene. Tumor genotyping is routinely performed from DNA extracted from tissue or cellular specimens from the primary tumor, metastases, or neoplastic effusions. Due to their invasiveness, these specimens are rarely repeated during the management...
December 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29175412/dissolving-microneedles-loaded-with-etonogestrel-microcrystal-particles-for-intradermal-sustained-delivery
#10
Meilin He, Guozhong Yang, Suohui Zhang, Xiaoyu Zhao, Yunhua Gao
This study presents a design that lipophilic drug was encapsulated within dissolving microneedles (DMNs) for sustained-release delivery over one week. Etonogestrel (ENG), the progestogen used in hormonal contraceptives, was loaded in two-layered DMNs in form of microcrystal particles (MP). In vitro release study indicated that ENG in form of MP could sustain drug release compared to non-crystal form. Hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) was used to prepare the fast dissolving needle-tips and flexible back layer, respectively...
November 23, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29174424/hemi-arthroplasty-performed-in-a-109-year-old-patient-with-intertrochanteric-fracture-a-case-report
#11
Peng-Fei Yang, Hao Chen, Xiao-Jun Duan, Guang-Xing Chen, Lin Guo, Hua-Quan Fan, Liu Yang
The mortality of conservative treatment and the risk resulting from operation for elderly patients with femoral intertrochanteric fractures are high. Safety in the perioperative period and quicker recovery should be placed at the top priority for elderly patients with hip fractures. We reported a case of 109-year-old female patient with intertrochanteric fracture who has undergone the hemiarthroplasty in our center recently. With sciatic nerve and lateral cutaneous nerve block anesthesia, she was offered the artificial femoral head replacement in the lumbar plexus block after sufficient preoperative preparation...
November 4, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29171793/preoperative-skin-antisepsis-with-chlorhexidine-gluconate-versus-povidone-iodine-a-prospective-analysis-of-6959-consecutive-spinal-surgery-patients
#12
George M Ghobrial, Michael Y Wang, Barth A Green, Howard B Levene, Glen Manzano, Steven Vanni, Robert M Starke, George Jimsheleishvili, Kenneth M Crandall, Marina Dididze, Allan D Levi
OBJECTIVE The aim of this study was to determine the efficacy of 2 common preoperative surgical skin antiseptic agents, ChloraPrep and Betadine, in the reduction of postoperative surgical site infection (SSI) in spinal surgery procedures. METHODS Two preoperative surgical skin antiseptic agents-ChloraPrep (2% chlorhexidine gluconate and 70% isopropyl alcohol) and Betadine (7.5% povidone-iodine solution)-were prospectively compared across 2 consecutive time periods for all consecutive adult neurosurgical spine patients...
November 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29157120/evaluating-nurse-understanding-and-participation-in-the-informed-consent-process
#13
Sydney A Axson, Nicholas A Giordano, Robin M Hermann, Connie M Ulrich
BACKGROUND: Informed consent is fundamental to the autonomous decision-making of patients, yet much is still unknown about the process in the clinical setting. In an evolving healthcare landscape, nurses must be prepared to address patient understanding and participate in the informed consent process to better fulfill their well-established role as patient advocates. RESEARCH OBJECTIVE: This study examines hospital-based nurses' experiences and understandings of the informed consent process...
January 1, 2017: Nursing Ethics
https://www.readbyqxmd.com/read/29141048/microcirculation-in-open-vs-minimally-invasive-dorsal-stabilization-of-thoracolumbar-fractures
#14
Bergita Ganse, Miguel Pishnamaz, Philipp Kobbe, Christian Herren, Gertraud Gradl-Dietsch, Franziska Böhle, Bernd Johannes, Bong-Sung Kim, Klemens Horst, Matthias Knobe
Standard open and percutaneous minimally invasive surgical procedures co-exist in the treatment of fractures of the thoracolumbar spine. Shorter skin incisions just above the pedicles are used in minimally invasive procedures. Full-length skin incisions and invasive preparations are applied in the standard open approach. While both methods show equivalent rates of intraoperative surgical complications and comparable clinical and radiological outcomes, blood loss and operation time have shown to be decreased in minimally invasive treatment...
2017: PloS One
https://www.readbyqxmd.com/read/29137684/use-of-an-intraoperative-navigation-system-and-piezoelectric-surgery-for-styloidectomy-in-a-patient-with-eagle-s-syndrome-a-case-report
#15
Shintaro Sukegawa, Takahiro Kanno, Akio Yoshimoto, Kenichi Matsumoto, Yuka Sukegawa-Takahashi, Masanori Masui, Yoshihiko Furuki
BACKGROUND: Elongated styloid process syndrome (Eagle's syndrome) is the term given to the symptomatic elongation of the styloid process or the mineralization of the stylohyoid or stylomandibular ligament. The two commonly used approaches for the surgical treatment of this syndrome are the transcervical and transoral approaches. Both have their limitations and specific intraoperative risks. Here, we report the treatment of a patient with Eagle's syndrome using the transoral approach in conjunction with piezoelectric surgery, surgical planning, and intraoperative navigation to reduce the risk of complications...
November 15, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29116741/high-performance-plga-magnetic-microspheres-prepared-by-rotating-membrane-emulsification-for-transcatheter-arterial-embolization-and-magnetic-ablation-in-vx2-liver-tumors
#16
Yi-Jun Liang, Hui Yu, Guodong Feng, Linlin Zhuang, Wei Xi, Ming Ma, Jun Chen, Ning Gu, Yu Zhang
Interventional embolization is a popular minimally invasive vascular therapeutic technique and has been widely applied for hepatocellular carcinoma (HCC) therapy. However, harmful effects caused by transcatheter arterial chemoembolization (TACE) and radioembolization, such as the toxicity of chemotherapy or excessive radiation damage, are serious disadvantages and significantly reduce the therapeutic efficacy. Here, a synergistic therapeutic strategy combined transcatheter arterial embolization and magnetic ablation (TAEMA) by using PLGA-magnetic microspheres (MMs) has been successfully applied to orthotopic VX2 liver tumors of rabbits...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29115844/scalable-fabrication-framework-of-implantable-ultrathin-and-flexible-probes-with-biodegradable-sacrificial-layers
#17
Xiangbing Jiao, Yuan Wang, Quan Qing
For long-term biocompatibility and performance, implanted probes need to further reduce their size and mechanical stiffness to match that of the surrounding cells, which, however, makes accurate and minimally invasive insertion operations difficult due to lack of rigidity and brings additional complications in assembling and surgery. Here, we report a scalable fabrication framework of implantable probes utilizing biodegradable sacrificial layers to address this challenge. Briefly, the integrated biodegradable sacrificial layer can dissolve in physiological fluids shortly after implantation, which allows the in situ formation of functional ultrathin film structures off of the initial small and rigid supporting backbone...
November 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/29111032/injectable-hydrogels-based-on-the-hyaluronic-acid-and-poly-%C3%AE-glutamic-acid-for-controlled-protein-delivery
#18
Xuebin Ma, Tingting Xu, Wei Chen, Hongye Qin, Bo Chi, Zhiwen Ye
Injectable hydrogels have great potential in minimally invasive delivery. In this work, novel injectable hydrogels were prepared via self-crosslinking of aldehyde hyaluronic acid (HA-CHO) and hydrazide-modified poly (γ-glutamic acid) (γ-PGA-ADH) for proteins delivery. The HA/γ-PGA hydrogels could be formed in situ as fast as 9s with high swelling ratios. Rheological properties illustrated a wide processing range and good mechanical properties, which were reflected by broad linear viscoelastic region and higher threshold shear stress (σc) and storage modulus (G')...
January 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29108896/brazilian-intragastric-balloon-consensus-statement-bibc-practical-guidelines-based-on-experience-of-over-40-000-cases
#19
Manoel Galvao Neto, Lyz Bezerra Silva, Eduardo Grecco, Luiz Gustavo de Quadros, André Teixeira, Thiago Souza, Jimi Scarparo, Artur A Parada, Ricardo Dib, Rena Moon, Josemberg Campos
BACKGROUND: Intragastric balloons (IGBs) are a minimally invasive option for obesity treatment, acting as a space-occupying device and leading to weight loss through increased satiety. This device has been growing in popularity owing to its safety profile and good weight loss results. However, there are no published guidelines that standardize the technical aspects of the procedure. OBJECTIVES: To create a practical guideline for intragastric balloon usage. SETTING: Private and Academic Settings, Brazil...
September 28, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29089558/a-total-transcriptome-profiling-method-for-plasma-derived-extracellular-vesicles-applications-for-liquid-biopsies
#20
Maria G Amorim, Renan Valieris, Rodrigo D Drummond, Melissa P Pizzi, Vanessa M Freitas, Rita Sinigaglia-Coimbra, George A Calin, Renata Pasqualini, Wadih Arap, Israel T Silva, Emmanuel Dias-Neto, Diana N Nunes
Extracellular vesicles (EVs) are key mediators of intercellular communication. Part of their biological effects can be attributed to the transfer of cargos of diverse types of RNAs, which are promising diagnostic and prognostic biomarkers. EVs found in human biofluids are a valuable source for the development of minimally invasive assays. However, the total transcriptional landscape of EVs is still largely unknown. Here we develop a new method for total transcriptome profiling of plasma-derived EVs by next generation sequencing (NGS) from limited quantities of patient-derived clinical samples, which enables the unbiased characterization of the complete RNA cargo, including both small- and long-RNAs, in a single library preparation step...
October 31, 2017: Scientific Reports
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