keyword
Keywords Salivary gland cancer, breast ...

Salivary gland cancer, breast cancer

https://read.qxmd.com/read/37216733/breast-adenoid-cystic-carcinoma-an-uncommon-neoplasm-case-report
#21
Mirza Rameez Samar, Wajiha Khan, Mehwish Mooghal, Saba Anjum, Azmina Tajuddin Vali Mohammad, Lubna Mushtaque Vohra
INTRODUCTION: Adenoid cystic carcinoma is a neoplasm that is commonly of salivary gland origin. It could infrequently arise from other tissues such as breast in which case it behaves favorably despite belonging to triple-negative breast cancer subgroup. CASE PRESENTATION: We report a case of a 49-year-old female patient, who presented with right breast pain and upon work-up, was diagnosed with early-stage adenoid cystic carcinoma of the breast. She underwent breast conservation successfully and was advised to get evaluated for adjuvant radiotherapy...
May 17, 2023: International Journal of Surgery Case Reports
https://read.qxmd.com/read/37194197/low-risk-of-some-common-cancers-in-women-with-anorexia-nervosa-evidence-from-a-national-record-linkage-study
#22
JOURNAL ARTICLE
Olena Seminog, Dixa B Thakrar, Anthony C James, Michael J Goldacre
BACKGROUND: Some studies report that women with anorexia nervosa (AN) have lower risk than others of breast cancer, but increased risk of cancers of other sites. No work has been done to quantify the risk in the English population. METHODS: Retrospective cohort study using a national linked dataset of Hospital Episode Statistics for 1999-2021. We selected individuals with a hospital admission for AN, and compared their relative risk (RR) of developing site-specific cancers, with that in a reference cohort...
May 16, 2023: Acta Psychiatrica Scandinavica
https://read.qxmd.com/read/37159817/adenoid-cystic-carcinoma-of-salivary-glands-a-ten-year-review-and-an-assessment-of-the-current-management-surgery-radiotherapy-and-chemotherapy
#23
REVIEW
Eyad Saleh, Abdouldaim Ukwas
Adenoid cystic carcinoma (ACC) is a rare cancer that arises from the salivary glands and other sites in the body, such as the lung and breast. Although the tumor accounts for 10% of all salivary gland malignancies, it only accounts for 1% of head and neck malignancies. It can affect both major and minor salivary glands; here, it is called salivary gland adenoid cystic carcinoma or SACC, with a slight predilection to the latter, and commonly manifests between the 6th and 7th decades of life. The disease also shows a slight female predilection, with a reported female to male ratio of 3 : 2...
2023: International Journal of Otolaryngology
https://read.qxmd.com/read/37144989/mucoepidermoid-carcinoma-of-the-breast-3-cases-report-and-literature-review
#24
REVIEW
Xin He, Jia You, Ying Chen, Hao Tang, Jingni Ran, Deyu Guo
RATIONALE: Mucoepidermoid carcinoma (MEC) is one of the most common malignant tumors in salivary glands, with specific histomorphological and molecular characteristics. MEC occurring in breast is more rare. PATIENT CONCERNS: We reported 3 cases of female breast mass, diagnosed as benign nodules by ultrasound. DIAGNOSES: The first 2 cases were pathological diagnosed as breast MEC, low grade, and the third case as breast MEC, medium grade. INTERVENTIONS: After pathological diagnosis, 3 patients have expanded the scope of breast resection and lymph node dissection, with negative margin and no lymph node metastasis...
May 5, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37138857/heterogeneity-and-versatility-of-the-extracellular-matrix-during-the-transition-from-pleomorphic-adenoma-to-carcinoma-ex-pleomorphic-adenoma-cumulative-findings-from-basic-research-and-new-insights
#25
REVIEW
João Figueira Scarini, Reydson Alcides de Lima-Souza, Luccas Lavareze, Maria Clara Falcão Ribeiro de Assis, Ingrid Iara Damas, Albina Altemani, Erika Said Abu Egal, Jean Nunes Dos Santos, Ibrahim Olajide Bello, Fernanda Viviane Mariano
Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%-60% of these neoplasms. If untreated, 6.2% of PA may undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA). CXPA is a rare and aggressive malignant tumor, whose prevalence represents approximately 3%-6% of all salivary gland tumors. Although the pathogenesis of the PA-CXPA transition remains unclear, CXPA development requires the participation of cellular components and the tumor microenvironment for its progression...
2023: Front Oral Health
https://read.qxmd.com/read/37114470/targeting-human-egfr-2-her2-in-salivary-gland-carcinoma
#26
JOURNAL ARTICLE
Michael Wotman, Adel El-Naggar, Renata Ferrarotto
INTRODUCTION: Human epidermal growth factor receptor 2 (HER2) protein overexpression, gene amplification, and activating mutations have been identified in a subset of salivary gland carcinoma (SGC) histologies (HER2-positive), especially in salivary duct carcinoma, and represent an important therapeutic target. AREAS COVERED: The evidence for targeting HER2 in the adjuvant setting is limited to small retrospective series. Conversely, there are prospective trials supporting the use of anti-HER2 therapy in patients with unresectable, recurrent, or metastatic HER2-positive SGC, including trastuzumab plus docetaxel, trastuzumab plus pertuzumab, trastuzumab-pkrb plus nanoxel, trastuzumab emtansine (T-DM1), and trastuzumab deruxtecan (T-Dxd)...
April 28, 2023: Expert Review of Anticancer Therapy
https://read.qxmd.com/read/37007224/a-case-of-gata3-positive-pleomorphic-liposarcoma-epithelioid-variant-a-diagnostic-pitfall
#27
Makoto Abe, Nobuo Hoshi, Sayuri Hoshi, Kaoru Hirabayashi, Kazutaka Kikuta, Toru Hirozane, Rumi Nakagawa, Tsukasa Mizuno, Hiroshi Nakamura, Koichi Inoue, Takehiko Yamaguchi
Pleomorphic liposarcoma is a rare malignant adipocytic tumor showing undifferentiated pleomorphic sarcoma morphology with various degrees of epithelioid features. It is sometimes difficult to distinguish from carcinoma metastasis. Immunohistochemical panel is very important for differential diagnosis; however, there is a risk that unexpected staining could lead to misinterpretation. We report a pleomorphic liposarcoma, epithelioid variant, in an 88-year-old man, with tricky-positive staining for GATA3. Histological examination revealed a tumor with epithelioid morphology...
2023: Case Reports in Pathology
https://read.qxmd.com/read/36980510/mammaglobin-a-expression-is-highly-specific-for-tumors-derived-from-the-breast-the-female-genital-tract-and-the-salivary-gland
#28
JOURNAL ARTICLE
Natalia Gorbokon, Patrick Timm, David Dum, Anne Menz, Franziska Büscheck, Cosima Völkel, Andrea Hinsch, Maximilian Lennartz, Andreas M Luebke, Claudia Hube-Magg, Christoph Fraune, Till Krech, Patrick Lebok, Till S Clauditz, Frank Jacobsen, Guido Sauter, Ria Uhlig, Stefan Steurer, Sarah Minner, Andreas H Marx, Ronald Simon, Eike Burandt, Christian Bernreuther, Doris Höflmayer
Human mammaglobin-A (SCGB2A2) is a secretory protein with an unknown function that is used as a diagnostic marker for breast cancer. However, other tumors can also express mammaglobin-A. To comprehensively study patterns of mammaglobin-A expression, a tissue microarray containing 16,328 samples from 128 different tumor types as well as 608 samples of 76 different normal tissue types was analyzed using immunohistochemistry. Mammaglobin-A positivity was found in only a few normal tissues, including luminal cells of the breast as well as endocervical and endometrial glands...
March 22, 2023: Diagnostics
https://read.qxmd.com/read/36940681/sex-specific-differences-in-the-risk-of-heart-failure-following-anti-her2-monoclonal-antibody-therapy
#29
Yuta Suzuki, Hidehiro Kaneko, Yuicui Tamura, Akira Okada, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Katsuhito Fujiu, Koichi Node, Hideo Yasunaga, Issei Komuro
BACKGROUND: Anti-HER2 monoclonal antibody is associated with a greater risk of heart failure (HF) in female breast cancer patients. In recent years, the indication of anti-HER2 monoclonal antibodies was further expanded to stomach, colorectal, and salivary gland cancers regardless of sex in Japan. However, there have been no data on sex difference in the risk of HF after the anti-HER2 monoclonal antibody treatment. OBJECTIVES: We compared the risk of HF between male and female cancer patients treated with anti-HER2 monoclonal antibody using a nationwide population-based database...
March 20, 2023: Oncology
https://read.qxmd.com/read/36935282/sialendoscopic-removal-of-metastatic-adenocarcinoma-in-a-mucous-plug-from-stensen-s-duct
#30
S L Pang, A W I Lo, R Wang, Y-X Su
Sialendoscopy is a minimally invasive technique used mainly in the diagnosis and treatment of obstructive salivary gland disorders. There has yet to be a report on its use in the diagnosis of metastatic disease. While metastatic cancer has been described in numerous head and neck anatomic subsites, it has not been reported to be found in a mucous plug in Stensen's duct. Sialendoscopy was performed in a 68-year-old female patient who presented with symptoms of ductal obstruction. Basket removal of a mucous plug was done and histopathological analysis of this specimen found adenocarcinoma...
March 17, 2023: International Journal of Oral and Maxillofacial Surgery
https://read.qxmd.com/read/36916425/the-molecular-landscape-of-breast-mucoepidermoid-carcinoma
#31
JOURNAL ARTICLE
Konstantinos Venetis, Elham Sajjadi, Mariia Ivanova, Silvia Andaloro, Simona Pessina, Chiara Zanetti, Alberto Ranghiero, Gabriele Citelli, Chiara Rossi, Marco Lucioni, Umberto Malapelle, Fabio Pagni, Massimo Barberis, Elena Guerini-Rocco, Giuseppe Viale, Nicola Fusco
Mucoepidermoid carcinoma (MEC) of the breast is an extremely rare salivary gland-type tumor characterized by epidermoid, basaloid, intermediate, and/or mucinous cells arranged in solid and cystic patterns. Despite their triple-negative phenotype, breast MECs are generally considered low-risk malignancies but their biology is largely unexplored; therefore, guidelines for clinical management are lacking. Here, we sought to characterize the molecular landscape of breast MECs. Thirteen cases were histologically reviewed, characterized for tumor-infiltrating lymphocytes (TILs), and were subjected to immunohistochemistry for programmed death-ligand 1 (PD-L1, clone 22C3), EGFR, and amphiregulin (AREG)...
March 14, 2023: Cancer Medicine
https://read.qxmd.com/read/36900183/dominant-gene-expression-profiles-define-adenoid-cystic-carcinoma-acc-from-different-tissues-validation-of-a-gene-signature-classifier-for-poor-survival-in-salivary-gland-acc
#32
JOURNAL ARTICLE
Kathryn J Brayer, Huining Kang, Adel K El-Naggar, Simon Andreasen, Preben Homøe, Katalin Kiss, Lauge Mikkelsen, Steffen Heegaard, Daniel Pelaez, Acadia Moeyersoms, David T Tse, Yan Guo, David Y Lee, Scott A Ness
Adenoid cystic carcinoma (ACC) is an aggressive malignancy that most often arises in salivary or lacrimal glands but can also occur in other tissues. We used optimized RNA-sequencing to analyze the transcriptomes of 113 ACC tumor samples from salivary gland, lacrimal gland, breast or skin. ACC tumors from different organs displayed remarkedly similar transcription profiles, and most harbored translocations in the MYB or MYBL1 genes, which encode oncogenic transcription factors that may induce dramatic genetic and epigenetic changes leading to a dominant 'ACC phenotype'...
February 22, 2023: Cancers
https://read.qxmd.com/read/36853778/sox17-a-highly-sensitive-and-specific-immunomarker-for-ovarian-and-endometrial-carcinomas
#33
JOURNAL ARTICLE
Xudong Zhang, Jun Yao, Na Niu, Xiaoran Li, Yan Liu, Lei Huo, Elizabeth D Euscher, Huamin Wang, Diana Bell, Anil K Sood, Guoliang Wang, Barrett C Lawson, Preetha Ramalingam, Anais Malpica, Aysegul A Sahin, Qingqing Ding, Jinsong Liu
PAX8 is the most commonly used immunomarker to link a carcinoma to the gynecologic tract; however, it lacks specificity. Through mining The Cancer Genome Atlas mRNA expression profile data, we identified SOX17 as a potential specific marker at the mRNA level for gynecologic tumors. To evaluate the utility of this marker in the identification of the gynecologic origin of a given carcinoma, we performed immunochemical staining in a large cohort of ovarian and endometrial cancer cases (n = 416), together with a large cohort of solid tumors from other organs (n = 1544) in tissue microarrays...
February 2023: Modern Pathology
https://read.qxmd.com/read/36759039/adenoid-cystic-carcinoma-of-the-breast-with-late-recurrence-and-high-grade-transformation
#34
JOURNAL ARTICLE
Gowtham Vasudevan, Ann Mary John, Vijaykumar D K, Archana George Vallonthaiel
Breast cancers have broad histological subtypes with varied molecular expression, which determines the management. Although ductal and lobular breast carcinomas constitute the significant 90% of these tumours, other subtypes constitute about 10% of breast cancers. Adenoid cystic carcinoma (AdCC) is a salivary gland-type tumour described in breast, constituting less than 1% of all breast carcinomas. These tumours have a favourable prognosis and are surgically managed by either lumpectomy or mastectomy. Solid-basaloid and AdCC with high-grade transformation are the sporadic subtypes of AdCC, in addition to the classic type...
February 9, 2023: BMJ Case Reports
https://read.qxmd.com/read/36649695/gata3-expression-in-human-tumors-a-tissue-microarray-study-on-16-557-tumors
#35
JOURNAL ARTICLE
Viktor Reiswich, Carol E Schmidt, Maximilian Lennartz, Doris Höflmayer, Claudia Hube-Magg, Sören Weidemann, Christoph Fraune, Franziska Büscheck, Katharina Möller, Christian Bernreuther, Ronald Simon, Till S Clauditz, Niclas C Blessin, Elena Bady, Guido Sauter, Ria Uhlig, Stefan Steurer, Sarah Minner, Eike Burandt, David Dum, Andreas H Marx, Till Krech, Patrick Lebok, Andrea Hinsch, Frank Jacobsen
INTRODUCTION: GATA3 is a transcription factor involved in epithelial cell differentiation. GATA3 immunostaining is used as a diagnostic marker for breast and urothelial cancer but can also occur in other neoplasms. METHODS: To evaluate GATA3 in normal and tumor tissues, a tissue microarray containing 16,557 samples from 131 different tumor types and subtypes and 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. RESULTS: GATA3 positivity was found in 69 different tumor types including 23 types (18%) with at least one strongly positive tumor...
January 17, 2023: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://read.qxmd.com/read/36619482/tumor-to-tumor-metastasis-to-warthin-tumor-presenting-as-an-initial-sign-of-breast-carcinoma-a-case-report
#36
Iisa Mansikka, Ilpo Kinnunen, Jussi Hirvonen, Paula Vainio, Jarno Velhonoja
Metastases of distant primary tumors on the parotid gland are very rare. Tumor-to-tumor metastasis to salivary gland tumors is extremely rare. A case of a 69-year-old woman with a large left parotid gland mass with no previous salivary gland problems or cancer. Fine-needle aspiration (FNA) showed evidence of a Warthin tumor. A total left parotidectomy was performed. The final pathology report showed a Warthin tumor containing two metastases of adenocarcinoma. The immunohistochemistry of the metastases led to the diagnosis of primary breast cancer...
January 2023: Clinical Case Reports
https://read.qxmd.com/read/36595080/-triple-negative-breast-cancer-classification-current-concepts-and-therapy-related-factors
#37
REVIEW
Hans-Peter Sinn, Zsuzsanna Varga
Triple-negative breast cancer (TNBC) accounts for about 10% of all breast cancer cases and is defined by the lack of expression of estrogen and progesterone receptors and the lack of overexpression or amplification of HER2. It differs with regard to the younger age of the patients, an increased association with a mutation of BRCA1 and a mostly low differentiation from hormone receptor-positive breast cancer. The spectrum of triple-negative breast cancer shows considerable heterogeneity both at the morphological and at the molecular level...
January 3, 2023: Pathologie (Heidelb)
https://read.qxmd.com/read/36408358/usefulness-of-global-longitudinal-strain-guided-management-in-preventing-human-epidermal-growth-factor-receptor-2-her2-inhibitor-induced-myocardial-damage
#38
JOURNAL ARTICLE
Kenta Yamada, Yudai Tamura, Hirohisa Taniguchi, Asuka Furukawa, Jin Iwasawa, Hirotaka Yada, Akio Kawamura, Yuichi Tamura
Background: Trastuzumab, an anti-human epidermal growth factor receptor 2 (HER2) monoclonal antibody, is a specific first-line treatment for patients with HER2-positive cancers. Cardiac dysfunction is among the most problematic adverse events associated with trastuzumab. Although regular echocardiographic screening is recommended for early detection of cardiac damage, few reports have investigated the validity of echocardiographic screening in chemotherapy. Therefore, the aim of this study was to determine whether a GLS-guided management approach could reduce cardiotoxicity and discontinuation of trastuzumab chemotherapy...
November 10, 2022: Circulation reports
https://read.qxmd.com/read/36398869/methods-for-preparing-tissue-microarray-slides-using-xenografts-with-different-levels-of-her2-expression-to-standardize-her2-detection
#39
JOURNAL ARTICLE
Keigo Yorozu, Mitsue Kurasawa, Yuki Iino, Yuka Nakamura, Kaoru Hashizume, Naoki Harada, Atsushi Ochiai
Gene amplification and protein overexpression of human epidermal growth factor receptor type 2 (HER2) are specific targets for HER2-targeting drugs in breast, gastric, salivary gland, and colorectal cancers. The histopathological determination of HER2 status is crucial for treatment, highlighting the importance of improving HER2 detection accuracy in clinical practice. We prepared tissue microarray (TMA) slides for use as control slides for the standardization of gastric HER2 testing. Four human gastric cancer cell lines with HER2 scores of 3+, 2+, 1+, and 0 were xenografted in NOG mice...
November 18, 2022: Pathology International
https://read.qxmd.com/read/36381227/metastasis-of-mucinous-breast-carcinoma-to-the-lower-alveolus-as-initial-presentation-a-diagnostic-dilemma
#40
JOURNAL ARTICLE
Priyadarshini Guha, Zachariah Chowdhury
Metastases in the oral cavity are rare and comprise approximately 1% of all oral malignancies. They usually involve the jaws but may also be found in the soft tissues and salivary glands. Women's most common metastatic malignancies are from primary breast cancers. However, metastasis of mucinous breast carcinoma to the lower alveolus mimicking an aggressive primary malignancy as the initial presentation is exceptionally uncommon. We describe the case of a 66-year-old lady with an ulceroproliferative growth in the right lower alveolus...
2022: Autopsy & Case Reports
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