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Eleni Pitta, Olga Balabon, Maciej K Rogacki, Jesús Gómez, Fraser Cunningham, Jurgen Joosens, Koen Augustyns, Pieter van der Veken, Robert Bates
During the construction of bioactive molecules, regioselective alkylation of heterocyclic, N/O ambident nucleophiles is a frequently encountered synthetic transformation. In this framework, specific attention is required to unambiguously determine the structures of obtained reaction products. As part of our project on quinoloxyacetamide based antimycobacterial agents, a series of N- or O- alkylated quinolin-4-ol, 1,5-naphthyridin-4-ol and quinazolin-4-ol derivatives were prepared during the course of which we observed unexpected selectivity issues...
October 11, 2016: European Journal of Medicinal Chemistry
Yu-Dong Ma, Varadharajan Thiyagarajan, May-Jywan Tsai, Sheng-I Lue, Yi-Chen Chia, Song-Kun Shyue, Ching-Feng Weng
Migration of vascular smooth muscle cells (VSMCs) contributes to intimal hyperplasia and other vascular diseases. Caveolin-1 (Cav-1) has been recognized as a proliferative inhibitor of VSMCs and is likely to be an important regulator of VSMC migration. The underlying mechanism of pyrogallol on the VSMC migration is not fully understood. This study attempted to dissect the role of Cav-1 and matrix metalloproteinase (MMP) in VSMC migration and to investigate the effect of pyrogallol on VSMC mobility during carotid artery ligation mice...
October 15, 2016: Environmental Toxicology and Pharmacology
Xiang-Xin Huang, Yun-Xuan Li, Xiang-Yu Li, Xiao-Xia Hu, Peng-Fei Tang, Guo-Xin Hu
Currently, crizotinib is the first generation drug, which has been used in the treatment of ALK-rearranged non-small cell lung cancer (NSCLC). However, more and more patients are found in crizotinib-resistance. In the last year, alectinib has been approved for treatment of patients with crizotinib-resistance. In this study, we aim to develop and validate a simple, rapid and sensitive tandem mass spectrometry (UHPLC-MS/MS) method for determination of alectinib in rat plasma. Diazepam was chosen as an internal standard (IS)...
October 14, 2016: Journal of Pharmaceutical and Biomedical Analysis
Martin Heberle, Stefanie Tschierlei, Nils Rockstroh, Mark Ringenberg, Wolfgang Frey, Henrik Junge, Matthias Beller, Stefan Lochbrunner, Michael Karnahl
A series of heteroleptic copper(I) photosensitizers of the type [(P^P)Cu(N^N)]+ with an extended π-system in the backbone of the diimine ligand have been prepared. The structures of all complexes are completely characterized by NMR spectroscopy, mass spectrometry and X-ray crystallography. These novel photosensitizers were assessed with respect to the photocatalytic reduction of protons in the presence of triethylamine and [Fe3(CO)12]. While the solid state structures and computational results show no significant impact of the π-extension on the structural properties decreased activities were observed...
October 21, 2016: Chemistry: a European Journal
Vincenzo Vindigni, Carlotta Scarpa, Erica Dalla Venezia, Franco Bassetto
INTRODUCTION: Fournier's gangrene is a rare disease that affects the genital, abdominal, and perineal regions and leads to death if not treated promptly. CASE REPORT: A 42-year-old, obese woman presented to the authors' department affected by Fournier's gangrene. In order to treat her abdominal and genital regions, the authors performed a surgical debridement followed by combined therapy with antibiotics and topical negative pressure wound therapy (NPWT) with instillation plus saline solution...
October 2016: Wounds: a Compendium of Clinical Research and Practice
Ian Chik, Enda G Kelly, Razman Jarmin, Farrah-Hani Imran
INTRODUCTION: Negative pressure wound therapy is a widely used method of wound dressing with various commercially available brands. The authors created the Hanikoda Method (HM) for effective wound bed preparation or definite wound closure. METHODS: In this case series, the authors discuss 8 different wound cases that presented to their Plastics Unit from January 2014 to June 2015. Patients with traumatic or infected wounds were selected for treatment with the HM...
October 2016: Wounds: a Compendium of Clinical Research and Practice
Wenjing Liu, Rami Al-Oweini, Karen Meadows, Bassem S Bassil, Zhengguo Lin, Jonathan H Christian, Naresh S Dalal, A Martin Bossoh, Israël M Mbomekallé, Pedro de Oliveira, Jamshed Iqbal, Ulrich Kortz
The dichromium(III)-containing heteropoly-16-tungstates [Cr(III)2(B-β-Si(IV)W8O31)2](14-) (1) and [Cr(III)2(B-β-Ge(IV)W8O31)2](14-) (2) were prepared via a one-pot reaction of the composing elements in aqueous, basic medium. Polyanions 1 and 2 represent the first examples of Cr(III)-containing heteropolytungstates comprising the octatungstate unit {XW8O31} (X = Si, Ge). Magnetic studies demonstrated that, in the solid state, the two polyanions exhibit a weak antiferromagnetic interaction between the two Cr(III)centers with J = -3...
October 21, 2016: Inorganic Chemistry
Natalia Eliza Domeradzka, Marc W T Werten, Frits A de Wolf, Renko de Vries
Previously, we developed triblock protein polymers that form fibrillar hydrogels at low protein polymer concentrations (denoted C2-SH48-C2). We here demonstrate that the structure of these hydrogels can be tuned via heterodimeric coiled coils that cross-link and bundle the self-assembled protein-polymer fibrils. We fused well-characterized, 47 amino acids-long heterodimeric coiled coil "linkers" (DA or DB) to the C-terminus of the triblock polymer. The resulting C2-SH48-C2-DA and C2-SH48-C2-DB polymers, were successfully produced as secreted proteins in Pichia pastoris, with titers of purified protein in the order of g L-1 of clarified broth...
October 21, 2016: Biomacromolecules
Susan L Garber
Every day, in clinics and hospitals around the world, occupational therapists care for patients with serious problems requiring viable solutions. Each patient is unique, and his or her problem does not necessarily correspond to existing practice models. Practitioners must adapt standard approaches to provide effective outcomes, yet problems exist for which few or no beneficial approaches have been identified. Such clinical issues require solutions to be generated de novo from the practitioner's body of knowledge and past experience...
November 2016: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Qi Wie, Yudong Cao, Sabre Kais, Bretislav Friedrich, Dudley Herschbach
We investigate several aspects of realizing quantum computation using entangled polar molecules in pendular states. Quantum algorithms typically start from a product state |00⋯0⟩ and we show that up to a negligible error, the ground states of polar molecule arrays can be considered as the unentangled qubit basis state |00⋯0⟩ . This state can be prepared by simply allowing the system to reach thermal equilibrium at low temperature (<1 mK). We also evaluate entanglement, characterized by concurrence of pendular state qubits in dipole arrays as governed by the external electric field, dipole-dipole coupling and number N of molecules in the array...
October 21, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Sebastian Stefanski, Börje Svensson, Andreas Thor
PURPOSE: Various augmentation procedures involving the maxillary sinus, using bone substitutes or bone, have been used to enhance bone support for dental implants. The aim of this study was to retrospectively evaluate the status of implants in patients who had undergone a maxillary sinus lift and immediate implant placement without the addition of graft material. MATERIALS AND METHODS: Nineteen patients who had required bone augmentation of their maxillary sinus floor were evaluated in this study...
October 20, 2016: Clinical Oral Implants Research
Marzieh Zargaran, Ebrahim Saadat, Rassoul Dinarvand, Mohammad Sharifzadeh, Farid Dorkoosh
Purpose: One of the most nutritional disorders around the world is iron deficiency. A novel iron compound was synthesized by chelating ferrous ions with alanine for prevention and treatment of iron deficiency anemia. Methods: The newly synthesized compound was characterized both qualitatively and quantitatively by Fourier Transform Infrared (FT-IR) spectroscopy. The bioavailability of newly synthesized iron micronutrient was evaluated in four groups of Wistar rats. The group I was a negative control group and the other three groups received three different iron formulations...
September 2016: Advanced Pharmaceutical Bulletin
Abolfazl Aslani, Behzad Zolfaghari, Fatemeh Davoodvandi
Purpose: Recurrent aphthous stomatitis is a disease with unknown etiology that's mostly treated symptomatically and has no definite cure. Pomegranate (Punica granatum) flowers have been used as medicinal herb that due to its antimicrobial, antioxidant, anti-inflammatory, analgesic and healing effects, has been useful in treatment of oral aphthous. Therefore, we decided to formulate a mucoadhesive gel with pomegranate flower extract to reduce the need for corticosteroid therapy in patients. Methods: Pomegranate flowers are extracted by percolation method...
September 2016: Advanced Pharmaceutical Bulletin
Kambham Venkateswarlu, Jami Komala Preethi, Kothapalli Bonnoth Chandrasekhar
Purpose: The aim of present study was to improve the dissolution rate of poorly soluble drug Loperamide (LPM) by liquisolid compact technique. Methods: Liquisolid compacts of LPM were prepared using Propylene glycol (PG) as a solvent, Avicel pH 102 as carrier, Aerosil as coating material and Sodium Starch Glycolate (SSG) as superdisintegrant. Interactions between the drug and excipients were examined by Fourier Transform Infrared (FTIR) spectroscopy. The dissolution studies for LPM liquisolid formulation, marketed product and pure drug were carried out in pH 1...
September 2016: Advanced Pharmaceutical Bulletin
Damian Hoy, Salanieta T Saketa, Roy Roger Maraka, Alison Sio, Ian Wanyeki, Pascal Frison, Divi Ogaoga, Dennie Iniakawala, Cynthia Joshua, Sala Duituturaga, Christelle Lepers, Adam Roth, Paul White, Yvan Souares
Mass gatherings pose public health challenges to host countries, as they can cause or exacerbate disease outbreaks within the host location or elsewhere. In July 2012, the 11th Festival of Pacific Arts (FOPA), a mass gathering event involving 22 Pacific island states and territories, was hosted by Solomon Islands. An enhanced syndromic surveillance (ESS) system was implemented for the event. Throughout the capital city, Honiara, 15 sentinel sites were established and successfully took part in the ESS system, which commenced one week before the FOPA (25 June) and concluded eight days after the event (22 July)...
July 2016: Western Pacific Surveillance and Response Journal: WPSAR
Clare F Heisey, J Derek Kingsley
Static stretching was once recognized as a method of preparation for physical activity that would inhibit performance and increase risk of injury. However, a growing body of research suggests that static stretching may not have an inhibitory effect. Regardless, the data have not examined gender differences or the fatigue index (FI) and flexibility effects of static stretching on the back squat over multiple sets. Therefore, the purpose of this study was to examine the relationship between a static-stretch condition (SC) and control condition (CC) on flexibility and the FI of Division I female athletes during 4 sets of the back squat...
2016: International Journal of Exercise Science
Mina Alvandipour, Shahram Ala, Hasan Tavakoli, Jamshid Yazdani Cherati, Afshin Shiva
INTRODUCTION: The most frequent problems after anal fistulotomy are pain, bleeding, and delayed or impaired wound healing. Topical Sucralfate preparation has been used to treat a wide variety of wounds. In this study, we investigate effects of 10% sucralfate ointment on wound healing and postoperative pain after fistulotomy. METHODS AND MATERIALS: A total of 41 patients undergoing anorectal fistulotomy were included in this randomized, blinded, controlled trial and were randomly allocated to either sucralfate ointment (every 12 h) or placebo...
October 17, 2016: International Journal of Surgery
S Mickenautsch
OBJECTIVES: To provide a brief overview of the current evidence-base for direct posterior tooth restorations in permanent teeth placed using high-viscosity glass-ionomer cement (HVGIC). METHODS: The evidence sources: laboratory trials, uncontrolled clinical trials, controlled clinical trials with HVGIC restorations placed after conventional cavity preparation by drill and controlled clinical trials with HVGIC restorations placed following the atraumatic restorative treatment (ART) approach, were assessed based on systematic reviews and meta-analyses, as well as methodological studies...
October 17, 2016: Journal of Dentistry
Sami Dogan, Ariel J Raigrodski, Hai Zhang, Lloyd A Mancl
STATEMENT OF PROBLEM: Studies evaluating anterior zirconia-based crowns are limited. PURPOSE: The purpose of this prospective cohort clinical study was to assess the efficacy of zirconia-based anterior maxillary crowns with 0.3-mm customized copings at the cervical third and anatomical design elsewhere for up to 5 years of service. MATERIAL AND METHODS: Eighteen participants who required an anterior maxillary crown (n=20) and who had signed a consent form approved by the University of Washington Health Sciences Center Human Subjects Division were enrolled...
October 17, 2016: Journal of Prosthetic Dentistry
Rica Capistrano I, Christel Vangestel, Hanne Vanpachtenbeke, Erik Fransen, Steven Staelens, Sandra Apers, Luc Pieters
BACKGROUND: Gloriosa superba L. (glory lily, Colchicaceae) contains colchicine, and related alkaloids such as 3-O-demethylcolchicine and its glycoside colchicoside. Previously the in vivo efficacy of a crude extract and a colchicine-poor / colchicoside-rich extract of G. superba seeds was shown in a murine model of pancreatic adenocarcinoma. HYPOTHESIS/PURPOSE: The efficacy can be improved without obvious signs of toxicity by increasing the treatment dose; the efficacy of gemcitabine can be improved by coadministration of a Gloriosa superba extract...
November 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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