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Shinae Choi, Minjung Kim, Ian M McDonough
OBJECTIVES: This study investigated the estate planning and advance care planning (ACP) of older adults diagnosed with Alzheimer's disease (AD) for the presence of (1) a valid will, (2) a durable power of attorney for health care, and (3) a living will. METHOD: We analyzed 10,273 adults aged 65 and older from the 2012 Health and Retirement Study (HRS) using multilevel logistic regression. RESULTS: We found that a diagnosis of AD was significantly associated with the ACP variables...
April 18, 2018: Aging & Mental Health
Jarrod Blinch, Jon B Doan, Claudia L R Gonzalez
There is a movement preparation cost for bimanual asymmetric reaching movements compared to bimanual symmetric movements. This is likely caused by the complex spatiotemporal coupling of bimanual asymmetric movements. The spatiotemporal coupling of bimanual reach-to-grasp movements has been investigated, but not the potential movement preparation costs. The purpose of the present study was to investigate the relationship between movement preparation costs and spatiotemporal coupling of reach-to-grasp movements...
April 17, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Yos Adi Prakoso, Kurniasih
The aim of this study is to explore the effect of topical application of Aloe vera on skin wound healing. Thirty-six male Sprague-Dawley rats weighing 150-200 grams were divided into four groups. All groups were anesthetized, shaved, and exposed to round full-thickness punch biopsy on the back: group I (control); group II (treated with 1% Aloe vera cream); group III (treated with 2% Aloe vera cream); and group IV (treated with madecassol®). The treatments were given once a day. Macroscopic and microscopic examination were observed at 5, 10, and 15 days after skin biopsy...
2018: Journal of Tropical Medicine
Hattanas Kumchai, Patrapan Juntavee, Arthur F Sun, Dan Nathanson
Objective: The purpose of this study was to evaluate the effect of glazing on flexural strength of highly translucent zirconia materials. Materials and Methods: Specimens of three brands of zirconia bars (Prettau Zirconia, Zirkonzahn; inCoris TZI, Sirona; and Zirlux FC, Pentron Ceramics) were prepared and polished according to manufacturers' instructions. Final specimen dimensions were 20 × 4 × 2 mm. The specimens from each brand were divided into 3 groups ( N  = 10): control, heat-treated, and glazed...
2018: International Journal of Dentistry
Mara C Romero, Ricardo A Fogar, Fabiana Rolhaiser, Verónica V Clavero, Ana M Romero, María A Judis
The goal of this study was to develop a fish-based product suitable for people with celiac disease. Water and gluten-free flours (rice, corn, amaranth or quinoa) were added to improve cooking yield, texture parameters and as an aid in improving quality attributes such as taste and juiciness. Cooking yields of patties containing gluten-free flours were higher than control and maximum values ranged between 91 and 93%. Hardness was higher in patties made with amaranth or quinoa flour, whereas cohesiveness and springiness were higher in patties made with corn and rice flour, respectively...
May 2018: Journal of Food Science and Technology
Gemma L Witcomb, Walter Pierre Bouman, Laurence Claes, Nicola Brewin, John R Crawford, Jon Arcelus
BACKGROUND: Depression is a serious disorder which significantly impacts wellbeing and quality of life. Studies exploring mental wellbeing in the transgender population are mostly limited by small, non-homogenous samples and lack of matched controls. This study aimed to address these limitations and explore depression rates in a large sample of transgender people, compared with matched controls from the general population, as well as factors predicting depression in those taking cross-sex hormone treatment (CHT) compared to those not...
February 17, 2018: Journal of Affective Disorders
Ping-Yueh Ho, Yao-Chung Chen, Shun Maekawa, Hsiang-Hui Hu, An-Wei Tsai, Yung-Fu Chang, Pei-Chi Wang, Shih-Chu Chen
A reverse vaccinology-based survey of potent antigens associated with fish nocardiosis was conducted using the largemouth bass, Micropterus salmoides, with an aim to develop subunit vaccines. The antigens selected from the virulent strain Nocardia seriolae 961113 include the gene products of NGL2579 (GAPDH), NGL5701 (MMP), NGL4377 (OCTase), NGL4486 (ABC transporter), NGL3372 (LLE), NGL3388 (GHf10), NGL6627 (Antigen-85), NGL6696 (Esterase), and NGL6936 (CBP). These antigens were heterologously expressed in E...
April 14, 2018: Fish & Shellfish Immunology
Katharine O White, Heidi E Jones, Jade Shorter, Wendy V Norman, Edith Guilbert, E Steve Lichtenberg, Maureen Paul
OBJECTIVE: To assess whether second-trimester surgical abortion practices of U.S. providers agree with evidence-based policy guidelines. STUDY DESIGN: We conducted a cross-sectional survey of abortion facilities in the U.S. identified via publicly available resources and professional networks from June through December 2013. RESULTS: Of 703 identified facilities, 383 (54%) participated including 172 clinicians providing second-trimester surgical abortions (D&Es)...
April 14, 2018: Contraception
Caitlin Curtis
Technology is constantly being used in novel ways, and its use in the practice of medicine is no exception. Examples of this include computer physician order entry, barcode-medication scanning, electronic health records (EHRs), and bedside patient charts, to name a few. Compounding parenteral nutrition has been included in this technological revolution, with improvements such as barcode-assisted medication preparation systems and EHR-to-compounder interfaces. Along with some of these electronic advancements come the inevitable improvements and challenges, which are explored in this article...
April 17, 2018: Nutrition in Clinical Practice
Nicholas J Walker, John C Crantford, Megan A Rudolph, Lisa R David
BACKGROUND: Adequate resident training in aesthetic surgery has become increasingly important with rising demand. Chief resident aesthetic clinics allow hands on experience with an appropriate amount of autonomy. The purpose of this study was to compare resident cosmetic clinic outcomes to those reported in the literature. Furthermore, we sought to assess how effective these clinics can be in preparing residents in performing common aesthetic surgery procedures. METHOD: A retrospective chart review of 326 patients and 714 aesthetic procedures in our chief cosmetic clinic over a 13-year period was performed, and complication and revision rates were recorded...
April 17, 2018: Annals of Plastic Surgery
Raffaele Senatore, Laura Castoldi, Laura Ielo, Wolfgang Holzer, Vittorio Pace
Diselenoacetals, previously considered byproducts in homologation tactics en route to α-selenoketones, are herein found to be excellent starting materials for this purpose. The easy selenium/lithium exchange they undergo affords seleno carbanions which are smoothly added to Weinreb amides to chemoselectively prepare α-aryl- and α-alkyl seleno methylketones through a single chemical operation. No racemization events are observed in the presence of optically pure starting materials.
April 17, 2018: Organic Letters
Hui Zhang, Xujun Qiu, Liqiong Lv, Wenyu Sun, Chaoyue Wang, Jizhong Yan, Shengqiang Tong
Recycling countercurrent chromatography was successfully applied to resolution of 2-(4-bromomethylphenyl)propionic acid, a key synthetic intermediate for synthesis of nonsteroidal anti-inflammatory drug loxoprofen, using hydroxypropyl-β-cyclodextrin as chiral selector. The two-phase solvent system composed of n-hexane/n-butyl acetate/0.1 mol L-1 citrate buffer solution with pH = 2.4 (8:2:10, v/v/v) was selected. Influence factors for the enantioseparation were optimized, including type of substituted β-cyclodextrin, concentration of hydroxypropyl-β-cyclodextrin, separation temperature and pH of aqueous phase...
April 17, 2018: Journal of Separation Science
Jessica Pearce, Melody Redman, Sareena Gajebasia, Ruth Dirksen
BACKGROUND: Ward rounds are fundamental to the care of medical inpatients, and newly graduated doctors may be expected to conduct them alone. There are no studies exploring the frequency with which this occurs, however, or how prepared they feel for this task. METHODS: Newly graduated (Foundation Year-1, FY1) doctors in Northern Lincolnshire and Goole (NLaG) National Health Service Foundation Trust were surveyed at the end of their FY1 year. An online survey asked: how often they conducted medical ward rounds alone; how prepared they felt to do so; and how often they considered 13 important aspects of care...
April 17, 2018: Clinical Teacher
Thomas P Forbes, Edward Sisco
Ambient mass spectrometry has evolved rapidly over the past decade, yielding a plethora of platforms and demonstrating scientific advancements across a range of fields from biological imaging to rapid quality control. These techniques have enabled real-time detection of target analytes in an open environment with no sample preparation and can be coupled to any mass analyzer with an atmospheric pressure interface; capabilities of clear interest to the defense, customs and border control, transportation security, and forensic science communities...
April 17, 2018: Analyst
Khaled Radad, Mubarak Al-Shraim, Ahmed Al-Emam, Rudolf Moldzio, Wolf-Dieter Rausch
INTRODUCTION: Domoic acid is a potent marine neurotoxin produced by certain species of the diatom genus Pseudonitzschia. To our knowledge, there are no studies that have investigated neurotoxic effects of domoic acid on dopaminergic neurons. Accordingly, the present study was carried out to investigate the potential neurotoxic effects of domoic acid on dopaminergic neurons in primary mesencephalic cell culture. MATERIAL AND METHODS: Cultures prepared from embryonic mouse mesencephala (total of 250 embryos) were treated with different concentrations of domoic acid (0...
2018: Folia Neuropathologica
Fraser Chisholm, Ourania Varsou
With an ever-expanding use of cross-sectional imaging for diagnostic and therapeutic purposes, there has also been an increase in the need for exposure to such radiological and anatomical views at the undergraduate and postgraduate level to allow for early familiarisation with the relevant anatomy. Cadaveric cross-sections offer an excellent link between the two-dimensional radiological images and the three-dimensional anatomical structures. For such cross-sections to be useful and informative within educational settings, they need to be: (i) safe for students and trainees to handle and (ii) robust enough to withstand repeated handling; as well as (iii) displaying anatomy clearly and accurately...
April 16, 2018: Journal of Anatomy
Soner Uzun, Mehmet S Gürel, Murat Durdu, Melih Akyol, Bilge Fettahlıoğlu Karaman, Mustafa Aksoy, Sema Aytekin, Murat Borlu, Esra İnan Doğan, Çiğdem Asena Doğramacı, Yelda Kapıcıoğlu, Ayşe Akman-Karakaş, Tamer I Kaya, Mehmet K Mülayim, Yusuf Özbel, Seray Özensoy Töz, Orhan Özgöztaşı, Yavuz Yeşilova, Mehmet Harman
BACKGROUND: Cutaneous leishmaniasis (CL) is a vector-born parasitic disease characterized by various skin lesions that cause disfiguration if healed spontaneously. Although CL has been endemic for many years in the southern regions of Turkey, an increasing incidence in nonendemic regions is being observed due to returning travelers and, more recently, due to Syrian refugees. Thus far, a limited number of national guidelines have been proposed, but no common Turkish consensus has emerged...
April 16, 2018: International Journal of Dermatology
Ruhi V Ubale, Prathap Nagaraja Shastri, Carl Oettinger, Martin J D'Souza
Targeted delivery to the lung for controlling lung inflammation is an area that we have explored in this study. The purpose was to use microparticles containing an antisense oligonucleotide (ASO) to NF-κB to inhibit the production of proinflammatory cytokines. Microparticles were prepared using the B-290 Buchi Spray Dryer using albumin as the microparticle matrix. Physicochemical characterization of the microparticles showed the size ranged from 2 to 5 μm, the charge was - 38.4 mV, and they had a sustained release profile over 72 h...
April 16, 2018: AAPS PharmSciTech
Hossein Maghsoudi, Jamal Hallajzadeh, Mozhghan Rezaeipour
Osteoarthritis (OA) is a chronic degenerative joint disease with inflammatory component. It is associated with progressive histological alterations and disabling symptoms. Today, drugs such as glucocorticoids (GCs) and nonsteroidal anti-inflammatory drugs (NSIADs) are commonly employed for treatment of osteoarthritis, but have serious and life-threatening side effects. The aim of the current study is to evaluate the effects of escin on cyclooxygenase-2 (COX-2, isoform), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), interleukin-18 (IL-18), tumor necrosis factor-alpha (TNF-α), and nitric oxide (NO) (1), as well as prostaglandin E2 (PGE2) on inflammatory cells, similar osteoarthritis in synoviocytes, and monocytes/macrophages, and to compare it with dexamethasone (DEX) and ibuprofen (IBP)...
April 16, 2018: Clinical Rheumatology
Ingrid Peroz, Triantafyllos Mitsas, Kurt Erdelt, Niko Kopsahilis
OBJECTIVES: The cementation process and cementation materials have an influence on the marginal adaptation of restorations. The gap could be affected by thermal and mechanical loading (TCML). The computerized x-ray microtomography (μCT) method offers the possibility of measuring the marginal gap without destruction of the restoration. The aim of this study was to evaluate the marginal gap (MG) and the absolute marginal discrepancy (AMD) before and after TCML. MATERIALS AND METHODS: Thirty-nine human premolars were prepared for full ceramic crowns made of lithium disilicate...
April 17, 2018: Clinical Oral Investigations
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