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Keywords Fine needle aspiration and thy...

Fine needle aspiration and thyroglobulin

https://read.qxmd.com/read/38529394/ultrasound-guided-fine-needle-aspiration-thyroglobulin-in-the-diagnosis-of-lymph-node-metastasis-of-differentiated-papillary-thyroid-carcinoma-and-its-influencing-factors
#1
JOURNAL ARTICLE
Xuejiao Su, Lei Shang, Can Yue, Buyun Ma
BACKGROUND: Ultrasound-guided fine needle aspiration thyroglobulin (FNA-Tg) is recommended for the diagnosis of lymph node metastasis (LNM) in differentiated thyroid cancer (DTC), but its optimal cutoff value remains controversial, and the effect of potential influencing factors on FNA-Tg levels is unclear. METHOD: In this study, a retrospective analysis was conducted on 281 patients diagnosed with DTC, encompassing 333 lymph nodes. We analyze the optimal cutoff value and diagnostic efficacy of FNA-Tg, while also evaluating the potential influence of various factors on FNA-Tg...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38520309/cytomorphology-of-monomorphic-spindle-epithelial-tumor-with-thymus-like-elements-a-case-with-local-recurrence-after-subtotal-resection
#2
JOURNAL ARTICLE
Asma Arshia, Lame Balikani, Christine N Booth
Spindle epithelial tumor with thymus-like elements (SETTLE) is a rare biphasic thyroid tumor with low malignant potential that has a distinct morphology. Despite fine needle aspiration (FNA) being a common method for evaluating thyroid nodules and lymph nodes, there are limited cytologic descriptions of SETTLE in the literature due to its rarity. As a result, SETTLE is frequently underdiagnosed or misdiagnosed as medullary carcinoma, thymoma, teratoma, synovial sarcoma, or solitary fibrous tumor, among others...
March 23, 2024: Diagnostic Cytopathology
https://read.qxmd.com/read/38482434/detection-of-thyroglobulin-for-diagnosis-of-metastatic-lateral-cervical-lymph-nodes-in-papillary-thyroid-carcinoma-accuracy-and-application-in-clinical-practice
#3
JOURNAL ARTICLE
Baolin Chen, Zhongliang Yan, Yuxiang Bao, Jiayang Li, Chengmin Luo, Guangxu Yang, Taolang Li, Xiaoming Cheng, Junyuan Lv
BACKGROUND: Accurate assessment of lateral cervical lymph node metastasis (LLNM) involvement is important for treating papillary thyroid carcinoma (PTC). Thyroglobulin is associated with LLNM, but there may be differences in the diagnostic value of serum thyroglobulin (sTg) and fine needle aspiration washout fluid thyroglobulin (FNA-Tg). Herein, we investigated the optimal cutoff value (OCV) of sTg and FNA-Tg and their diagnostic performance. METHODS: We enrolled 116 PTC patients who underwent radical resection of thyroid carcinoma with lateral cervical lymph node dissection at the Affiliated Hospital of Zunyi Medical University from June 2018 to July 2022...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38304356/simultaneous-metastases-of-papillary-thyroid-carcinoma-and-neuroendocrine-tumor-of-the-cecum-to-cervical-lymph-nodes-a-case-report
#4
Matija Romić, Ivan Blažeković, Neven Mateša, Maja Franceschi, Ines Šiško-Markoš, Zvonko Kusić, Ana Fröbe, Tomislav Jukić
We present a case of a patient with simultaneous cervical lymph node metastasis of papillary thyroid cancer (PTC) and cecum neuroendocrine tumor (NET). A 45-year-old male patient with the diagnosis of metastatic NET of the cecum underwent fine needle aspiration (FNA) of a positron emission tomography with 18F-fluorodeoxyglucose (18F-FDG PET) positive nodule in the left thyroid lobe. Due to FNA finding suspect of PTC, the patient underwent total thyroidectomy with central neck dissection. Histopathologic finding revealed PTC of the left thyroid lobe and small solitary lymph node PTC metastasis in the central neck region...
April 2023: Acta Clinica Croatica
https://read.qxmd.com/read/38272022/thyroid-hormone-resistance-and-large-goiter-mimicking-infiltrative-carcinoma-in-a-pediatric-patient
#5
Carly Baxter, Claudia Martinez-Rios, Alexandra Ahmet
BACKGROUND: Resistance to thyroid hormone (RTH) is a genetic condition, caused by mutations in the thyroid hormone receptor gene and characterized by impaired end organ responsiveness to thyroid hormone. Here we describe a novel case of THR associated with large goiter mimicking infiltrative c. CASE PRESENTATION: A 13-year-old male with a hyperthyroid phenotype of RTH diagnosed as a toddler, on methimazole and nadolol therapies presented with an increase in goiter size and possible nodule...
January 25, 2024: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://read.qxmd.com/read/38221623/warthin-like-variant-of-papillary-thyroid-carcinoma-with-lymph-node-metastases-a%C3%A2-case-report-and-review%C3%A2-of-the-literature
#6
REVIEW
Andrii Hryshchyshyn, Andrii Bahrii, Pavlina Botsun, Volodymyr Chuba
BACKGROUND: We present a rare case of thyroid lesion marked as the Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) with lymph node metastases. A proper preoperative identification is difficult because of unspecific cytology features and common ultrasound characteristics of this malignant tumor. The long-term prognosis cannot be thoroughly described due to the scarcity of data. The purpose of the presentation is to show common characteristics and long-term survival rates of an uncommon variant of differentiated thyroid cancer (DTC)...
January 15, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38181005/the-diagnostic-value-of-gica-used-for-intraoperative-lymph-node-fna-tg-measurement-to-evaluate-thyroid-cancer-metastases
#7
JOURNAL ARTICLE
Shaodong Hou, Yiceng Sun, Zeyu Yang, Mi Tang, Tingjie Yin, Cong Shao, Cunye Yan, Linlong Mo, Yuquan Yuan, Supeng Yin, Fan Zhang
OBJECTIVE: It is crucial to diagnose lymph node (LN) metastases (LNM) before or during thyroid carcinoma surgery. Measurement of thyroglobulin (Tg) in fine-needle aspirate washout (FNA-Tg) is useful to assist in the diagnosis of LNM for papillary thyroid carcinoma (PTC). This study aimed to assess the diagnostic performance of a new technique based on a colloidal gold-based immunochromatographic assay (GICA) for intraoperative FNA-Tg in diagnosing LNM. METHODS: This prospective study enrolled 51 PTC patients who underwent cervical LN dissection...
January 1, 2024: European Thyroid Journal
https://read.qxmd.com/read/38089614/constructing-a-nomogram-based-on-the-distribution-of-thyroid-nodules-and-suspicious-lateral-cervical-lymph-nodes-in-fine-needle-aspiration-biopsies-to-predict-metastasis-in-papillary-thyroid-carcinoma
#8
JOURNAL ARTICLE
Shui-Qing Liu, Jia-Wei Feng, Zhan-Tao Yan, Xiao-Xiao Xing, Wen-Yin Jiang, Yong Jiang, Feng Qian, Wei Xing
PURPOSE: Elevated concentrations of thyroglobulin eluent is a risk factor for lateral cervical lymph node metastasis (LLNM) in patients with papillary thyroid cancer (PTC). We aimed to develop a practical nomogram based on the distribution of thyroid nodules and the presence of suspicious lateral cervical lymph nodes in fine-needle aspiration biopsies (LN-FNABs), including the cytopathology and the suspicious lateral cervical lymph node (LLN) thyroglobulin eluent (Tg), to predict the possibility of LLNM preoperatively in patients with PTC...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/38065908/diagnostic-value-of-thyroglobulin-washout-in-fine-needle-aspiration-samples-for-diagnosis-and-follow-up-of-differentiated-thyroid-cancer
#9
JOURNAL ARTICLE
Sinem Kargun, Mustafa Aydemir, Nusret Yilmaz, Sebahat Ozdem, Ramazan Sari
Our goal was to assess the effectiveness of fine-needle aspiration thyroglobulin (FNA-Tg) in detecting malignant lymph nodes (LNs) in patients with differentiated thyroid cancer (DTC). We also aimed to determine the factors that affect the accuracy of FNA-Tg. We conducted a retrospective cohort study using the laboratory, ultrasonographic, histopathological, FNA cytology (FNA-C), and FNA-Tg results of 176 DTC patients. We used receiver operating characteristic analysis to identify the cutoff value of FNA-Tg, and binary regression analysis to compare FNA-Tg with other diagnostic parameters...
December 8, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38009335/lymph-node-imaging-for-thyroid-cancer
#10
REVIEW
Simon A Holoubek, Rebecca S Sippel
Cervical lymph nodes (LNs) in the central (level VI) and lateral (levels II-V) compartments of the neck are the most common sites of locoregional metastases associated with thyroid cancer. Prophylactic nodal dissections are uncommon in modern thyroid surgery and are not routinely performed due to concern for increased morbidity and do not offer improved survival. Therefore, a selective approach for LN dissections is increasingly important. Preoperatively, this is most frequently assessed with cervical ultrasound (US)...
November 27, 2023: Clinical Endocrinology
https://read.qxmd.com/read/37908474/a-rare-case-of-thyroglossal-duct-cyst-cancer-and-literature-review
#11
Ashima Mittal, Ariel Sandhu, Mamta Chhetri, Gayatri Jaiswal
Thyroglossal duct cyst is the most common thyroid developmental abnormality with a prevalence of 7%, but thyroglossal duct cyst cancer is rare. The incidence of thyroglossal duct cyst cancer is about 1%. The diagnosis is limited by low yield on fine-needle aspiration biopsy (FNAB), and most cases are diagnosed after surgery. There is a paucity of data on the utility of thyroglobulin washout for diagnosis of thyroglossal duct cyst cancer, and it has not been mentioned in previous case reports/series. Papillary thyroid cancer is the most common pathology...
March 2023: JCEM Case Rep
https://read.qxmd.com/read/37899801/determination-of-diagnostic-features-of-serum-thyroid-hormones-and-thyroglobulin-ratios-in-normothyroid-differentiated-thyroid-carcinoma-cases
#12
JOURNAL ARTICLE
Yunushan Furkan Aydogdu, Umut Emreol, Gulcek Emre, Cagri Buyukkasap, Murat Akin
OBJECTIVES: Ultrasonography and fine-needle aspiration biopsy (FNAB) are the gold standard methods in the prediction of benign and malignant thyroid nodules. However, despite being easily applicable, FNAB is an invasive procedure. Less invasive biomarkers should be utilized in the diagnosis of thyroid malignancies. In this study, we aimed to determine the parameters that can be used in the diagnosis of differentiated thyroid cancer (DTC) based on the serum thyroid and thyroglobulin (TG) levels which are routinely checked in patients followed up for thyroid nodules...
2023: Şişli Etfal Hastanesi tıp bülteni
https://read.qxmd.com/read/37880965/cribriform-morular-thyroid-carcinoma-a-rare-case-and-associated-uncommon-features
#13
JOURNAL ARTICLE
Ajit Sahu, Mohammed Shahin, Priyansh Jain, Mahesh Sultania, Pavithra Ayyanar
Cribriform morular thyroid carcinoma has been added under tumors of uncertain histogenesis. Its peculiar clinical, histomorphological pattern, and immunohistochemical profile have been proved different from papillary thyroid carcinoma. A 59-year-old female patient had a lesion in the left lobe of the thyroid. Fine needle aspiration cytology was reported as medullary thyroid carcinoma. The total thyroidectomy specimen showed a predominantly solid tumor of size 9.5 cm in the left lobe. Microscopy showed a mixed growth pattern with the dominant cribriform and solid morular area...
October 25, 2023: International Journal of Surgical Pathology
https://read.qxmd.com/read/37842300/nitric-oxide-thyroglobulin-and-calcitonin-unraveling-the-nature-of-thyroid-nodules
#14
JOURNAL ARTICLE
Vladimir S Samardzic, Mirjana T Macvanin, Sonja S Zafirovic, Milan M Obradovic, Zoran M Gluvic, Jasmina Grubin, Xin Gao, Magbubah Essack, Esma R Isenovic
BACKGROUND: Thyroid nodules (TN) are localized morphological changes in the thyroid gland and can be benign or malignant. OBJECTIVE: The present study investigates the relationships between biochemical markers in serum (s) and their homologs in washout (w) after fine-needle aspiration biopsy (FNAB) of the TN of interest and their correlation with cytology specimen findings. METHODS: We investigated the relationships between serum biochemical markers nitric oxide (NO), thyroglobulin (TG), and calcitonin (CT), their homologs in washout after FNAB of the TN of interest, and cytology findings of biopsy samples classified according to the Bethesda system for thyroid cytopathology in this study, which included 86 subjects...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/37760874/cut-off-value-for-thyroglobulin-washout-concentration-in-the-detection-of-cervical-lymph-node-metastases-in-patients-after-thyroidectomy-due-to-differentiated-thyroid-cancer
#15
JOURNAL ARTICLE
Paweł Mikosiński, Emilia Wołowiec-Korecka, Lech Pomorski, Agnieszka Mikosińska, Krzysztof Kaczka, Sławomir Mikosiński
The aim of this study was to establish the cut-off value for the thyroglobulin (Tg) concentration in washout fluid from fine needle aspiration biopsy (FNA-Tg) in the detection of cervical lymph node metastases of differentiated thyroid cancer (DTC). We evaluated the validity and clinical utility of fine needle aspiration biopsy cytology (FNAB-C), FNA-Tg, and the combined method in detecting DTC recurrences. The study included 82 patients after the total thyroidectomy and elective and, in some cases, also selective cervical lymphadenectomy...
August 31, 2023: Biomedicines
https://read.qxmd.com/read/37649029/diagnostic-dilemma-in-a-patient-with-history-of-medullary-thyroid-carcinoma-and-abnormal-serum-liver-enzymes-a-case-report-with-six-years-follow-up
#16
JOURNAL ARTICLE
Fatemeh Rahmani, Maryam Tohidi, Farid Azmoudeh-Ardalan, Amir Sadeghi, Farzad Hadaegh
BACKGROUND: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that originates from parafollicular C-cells. Calcitonin (Ctn) and carcinoembryonic antigen (CEA) are useful biomarkers for monitoring MTC cases. CASE PRESENTATION: Here, we describe a 48-year-old woman, who presented in 2014 with bilateral thyroid nodules. Report of fine needle aspiration was suspicious for MTC; initial laboratory evaluation showed serum Ctn level of 1567 pg/mL. After excluding type 2 multiple endocrine neoplasia syndrome clinically, total thyroidectomy and neck lymph node dissection were performed...
August 30, 2023: BMC Endocrine Disorders
https://read.qxmd.com/read/37519189/diagnostic-role-of-fna-cytology-in-the-evaluation-of-cervical-lymph-nodes-in-thyroid-cancers-combined-evaluation-of-thyroglobulin-in-eluate-from-fna-cytology
#17
JOURNAL ARTICLE
Pietro Tralongo, Carmine Bruno, Federica Policardo, Federica Vegni, Angela Feraco, Angela Carlino, Giulia Ferraro, Domenico Milardi, Elena Navarra, Alfredo Pontecorvi, Celestino Pio Lombardi, Marco Raffaelli, Luigi Maria Larocca, Liron Pantanowitz, Esther Diana Rossi
BACKGROUND: The presurgical evaluation of cervical lymph nodes (CLNs) in the management of thyroid malignant lesions is crucial for the extent of surgery or detection of metastases. In these last decades, fine-needle aspiration cytology (FNAC) has been shown to have a central role in the detection of nodal thyroid metastases. It is adopted for the possibility of confirming suspected metastases either in the presurgical phase or in the follow-up of patients after thyroidectomy. However, FNAC from CLNs can be challenging, especially in cystic lesions...
July 31, 2023: Cancer Cytopathology
https://read.qxmd.com/read/37493833/metastatic-diffuse-follicular-variant-papillary-thyroid-cancer-without-cervical-lymph-node-metastasis-presenting-with-symptoms-related-to-hypopituitarism
#18
Muhammed Kızılgül, Ömer Bayır, Bekir Uçan, Pınar Akhanlı, Hakan Düğer, Muhammed Erkam Sencar, Hayri Kertmen, Demet Yılmazer, Doğan Yazılıtaş, Güleser Saylam, Mehmet Hakan Korkmaz, Erman Çakal
In this article, we present a case of diffuse follicular variant papillary thyroid carcinoma with pituitary metastasis, which is a rare cause of pituitary metastasis. The follicular variant of papillary thyroid carcinoma is an uncommon variant of papillary carcinoma. A 74-year-old male was presented with weakness, fatigue, and a decreased appetite. The patient was diagnosed with secondary adrenal and thyroid insufficiencies. Imaging revealed a pituitary mass with suprasellar extension, right cavernous sinus invasion, and optic chiasm compression...
2023: Einstein
https://read.qxmd.com/read/37484755/laterocervical-lymph-node-metastases-from-suspected-thyroidal-primary-site-that-turned-out-to-be-metastases-of-lung-cancer-a-case-report
#19
Chiara Scorziello, Maria Carola Borcea, Marco Biffoni, Angelina Pernazza, Francesca Arienzo, Rossella Melcarne, Luca Ventrone, Angelo Laca, Giorgio Grani, Cosimo Durante, Fabrizio Consorti, Laura Giacomelli
Incidental sonographic discovery of thyroid nodules is an increasingly common event in clinical practice. Less frequently, patients with cytological benign thyroid nodules have suspicious cervical lymph nodes detected by ultrasound examination or by cytological exam. Here, we discuss an intriguing case of cervical lymph node metastasis with a probable thyroid origin in a 65-year-old asymptomatic male smoker. He underwent thyroidectomy and unilateral cervical lymphadenectomy. Despite a negative chest X-ray, the postoperative histological examination revealed that the lymph node metastasis was actually from a lung carcinoma...
July 2023: Clinical Case Reports
https://read.qxmd.com/read/37208007/metastatic-recurrence-of-lung-adenocarcinoma-in-thyroid-clinically-masquerading-as-primary-thyroid-cancer-and-immunohistochemically-positive-for-thyroglobulin
#20
JOURNAL ARTICLE
Kenji Yorita, Norihiro Hokimoto, Nobuyuki Tanida, Hisashi Matsuoka
We report a case of a man in his 60s with metastatic lung adenocarcinoma in the thyroid and cervical lymph nodes. The lung cancer was resected 5 years prior to presentation. The metastasis mimicked primary thyroid cancer by clinical examination and CT. However, fine-needle aspiration cytology of the thyroid and the lymph node lesions favoured lung cancer metastasis rather than thyroid cancer. Left thyroid lobectomy and lymphadenectomy were performed. Pathology confirmed the presence of an adenocarcinoma in the thyroid and two lymph nodes, which was similar to the previous lung cancer...
May 19, 2023: BMJ Case Reports
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