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Fine needle aspiration and tg

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https://www.readbyqxmd.com/read/29134304/outcome-of-thyroid-carcinoma-showing-thymus-like-differentiation-in-patients-undergoing-radical-resection
#1
Wenwu Dong, Ping Zhang, Jian Li, Liang He, Zhihong Wang, Ting Zhang, Liang Shao, Hao Zhang
BACKGROUND: Carcinoma showing thymus-like differentiation (CASTLE) is a rare malignant tumor of the thyroid. It is difficult to diagnose, and there is no universally recognized therapeutic regimen. This study aims to define the clinicopathological features and discuss the optimal management of CASTLE. METHODS: We retrospectively analyzed six patients with CASTLE who accepted surgery at the First Hospital of China Medical University between January 2010 and December 2015...
November 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29121688/long-term-follow-up-in-patients-with-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-without-a-suspicion-of-persistent-disease-in-postoperative-assessment
#2
Pedro Weslley Rosario, Gabriela Franco Mourão, Luís Fernando Faria Oliveira, Maria Regina Calsolari
The objective was to determine whether negative assessment after surgery is a predictor of no relevant change of the results in subsequent evaluations in patients with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Six months after surgery, "absence of persistent disease" was defined when concentration of thyroglobulin (Tg) is ≤2 ng/ml in patients undergoing total thyroidectomy and ≤10 ng/ml in those undergoing lobectomy, in the absence of antithyroglobulin antibodies (TgAb), and neck ultrasonography (US) without abnormalities...
November 9, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29017315/thyroid-cytology-the-japanese-system-and-experience-at-yamashita-thyroid-hospital
#3
REVIEW
Shinya Satoh, Hiroyuki Yamashita, Kennichi Kakudo
In Japan, fine-needle aspiration (FNA) cytology is the most important diagnostic modality for triaging patients with thyroid nodules. A clinician (endocrinologist, endocrine surgeon, or head and neck surgeon) generally performs FNA cytology at the outpatient clinic, and ultrasound (US)-guided FNA is widespread because US is extremely common and most clinicians are familiar with it. Although almost all FNA thyroid samples are examined by certified cytopathologists and pathologists, some clinicians assess cytological specimens themselves...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28979135/intraoperative-measurement-of-thyroglobulin-in-lymph-node-aspirates-for-the-detection-of-metastatic-papillary-thyroid-carcinoma
#4
Yizeng Wang, Yuanchao Liu, Xiaoning Wang, Xin Li, Ruoyu Jiang, Xianghui He
BACKGROUND: Among patients with papillary thyroid carcinoma (PTC), 30%-80% have cervical lymph node (LN) metastases, which are most commonly located in the central compartment. However, preoperative ultrasonography identifies malignant central compartment LNs in only 20%-30% of cases. We aimed to evaluate the diagnostic value of intraoperative thyroglobulin (Tg) measurement in fine-needle aspirates (FNA-Tg) of suspicious metastatic LNs. METHODS: In total, 75 patients (75 LNs) with PTC or suspected PTC were enrolled in this study...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28900610/the-role-of-intraoperative-thyroglobuline-level-of-lymph-node-in-the-management-of-papillary-thyroid-cancer-determination-of-a-cutoff-point
#5
Mohsen Kolahdouzan, Mehdi Sadeghi, Behrooz Kalidari, Behnam Sanei, Elyas Mostafapour, Ashraf Aminorroaya
BACKGROUND: Some studies have shown that a preoperative high concentration of thyroglobulin (Tg) in wash out of fine-needle aspiration cytology of cervical lymph nodes mandate therapeutic lymph node dissection. However, there is disagreement about the minimum concentration of Tg which could have diagnostic value. Hence, according to our literature review, this study is the first one which designed to do intraoperatively. Therefore, this study was conducted and aimed to determine the clinical diagnostic value of Tg lymph nodes in the diagnosis of metastatic thyroid cancer...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28868258/thyroid-autoimmunity-and-thyroid-cancer-review-focused-on-cytological-studies
#6
REVIEW
Francesco Boi, Fabiana Pani, Stefano Mariotti
The association between Hashimoto thyroiditis (HT) and papillary thyroid carcinoma (PTC) has been originally suggested by retrospective pathological studies and has recently been re-evaluated and proposed on the basis of several fine-needle aspiration cytology (FNAC) studies. In FNAC studies, the association between HT and PTC is based on the comparison of anti-thyroid autoantibodies (ATA) (anti-thyroperoxidase [TPOAb] and anti-thyroglobulin [TgAb]), thyroid function (TSH), and cytology with histology of thyroid nodules and lymphocytic thyroid infiltration (LTI) of operated thyroid glands...
July 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28760234/thyroid-cancer-ultrasound-imaging-and-fine-needle-aspiration-biopsy
#7
REVIEW
Michelle Melany, Sardius Chen
Ultrasound is critical in detection, diagnosis, and management of thyroid nodules. Ultrasound detection of regional nodal metastatic disease is based on abnormal nodal morphology rather than size and is critical to initial surgical and long-term management of thyroid cancer. Fine-needle aspiration biopsy is the gold standard for malignancy diagnosis in thyroid cancer. Thyroglobulin assay of nodal aspirates improves accuracy in diagnosis of metastases. Reporting lexicons assign risk levels to thyroid nodules with the goal of improving and standardizing patient management...
September 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/28558632/thyroglobulin-determination-in-fine-needle-aspiration-biopsy-washout-of-suspicious-lymph-nodes-in-thyroid-carcinoma-follow-up
#8
Gaetano Achille, Vito Michele Garrisi, Edoardo Guastamacchia, Vito Angelo Giagulli, Antonio Tufaro, Vito Cafagna, Stefania Zizzi, Marilena Centrone, Giovanni Simone, Ines Abbate, Vincenzo Triggiani
BACKGROUND: Differentiated thyroid carcinomas (DTCs) account for about 1% of all human malignancies. Cervical lymph nodes metastases and recurrences in the thyroid bed frequently occur. Furthermore, about 10-15% of patients develop distant metastases. Therefore, patients must undergo life-long follow-up. OBJECTIVE: The aim of this study was to evaluate the usefulness of Thyroglobulin measurement in FNAB washout (FNAB-Tg) in the detection of local metastasis in patients affected by or evaluated for thyroid cancer...
May 30, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28493290/circulating-thyroid-cancer-biomarkers-current-limitations-and-future-prospects
#9
REVIEW
Alexander M Nixon, Xeni Provatopoulou, Eleni Kalogera, George N Zografos, Antonia Gounaris
Differentiated thyroid cancer (DTC) is the most common malignancy of the endocrine system. There has been a significant increase in its incidence over the past two decades attributable mainly to the use of more sensitive diagnostic modalities. Ultrasound-guided fine needle aspiration cytology is the mainstay of diagnosis of benign disorders and malignancy. However, approximately 20% of lesions cannot be adequately categorized as benign or malignant. In the postoperative setting, monitoring of thyroglobulin (Tg) levels has been employed for the detection of disease recurrence...
August 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28490006/adenoid-cystic-carcinoma-of-the-larynx-presenting-as-a-thyroid-mass-and-brief-literature-review
#10
REVIEW
Sadegh Shirian, Maryam Maghbool, Azita Aledavood, Shahrzad Negahban, Bijan Khademi, Yahya Daneshbod
BACKGROUND: Adenoid cystic carcinoma (ACC) of the larynx and trachea is very rare. CASE: A 45-year-old man with ACC of the larynx presenting as a thyroid mass is reported in this study. Physical examination revealed a large solid thyroid nodule in the left lobe without any lymphadenopathy. A technetium thyroid scan showed multinodular goiter with cold nodules in the left lobe, isthmus, and functioning nodules in the right lobe. A large thyroid mass originating from the left side of the larynx, mostly the left vocal cord and the infraglottic part, was seen using enhanced magnetic resonance imaging after rupture of the thyroid cartilage on the left side...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28454525/influence-of-presence-absence-of-thyroid-gland-on-the-cutoff-value-for-thyroglobulin-in-lymph-node-aspiration-to-detect-metastatic-papillary-thyroid-carcinoma
#11
Huan Zhao, Yong Wang, Min-Jie Wang, Zhi-Hui Zhang, Hai-Rui Wang, Bing Zhang, Hui-Qin Guo
BACKGROUND: Thyroglobulin measurement with fine-needle aspiration (Tg-FNA) is a sensitive method for detecting metastatic papillary thyroid carcinoma (PTC). However, the diagnostic threshold is not well established and the influence of the thyroid gland on the cutoff value is also controversial. In this study, patients were classified into two groups according to the presence or absence of thyroid tissue, to determine an appropriate cutoff value for clinical practice. METHODS: Patients with a history of thyroid nodules or surgery for PTC and with enlarged cervical lymph nodes on an FNA examination were enrolled for Tg-FNA detection...
April 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28386723/effects-of-sample-storage-and-diluents-in-the-reliability-of-thyroglobulin-measurement-in-the-washout-of-fine-needle-aspirates
#12
Fanny Piotrkowski-Viale, Adriana Reyes, Alicia Dios, Fabian Pitoia, Alicia Lowenstein, Patricia Glikman
OBJECTIVE: To evaluate two variables affecting Thyroglobulin stability in the washout of fine needle aspiration biopsies of thyroid nodules and metastatic lymph nodes. MATERIALS AND METHODS: Thyroglobulin stability after storage at -20 °C up to 14 days was studied in washout performed with normal saline solution and further dilutions with normal saline solution from five metastatic thyroid nodes and six benign thyroid nodules. We also studied thyroglobulin stability in diluents compared with normal saline solution: 4% bovine serum albumin in normal saline solution and diluents free from thyroglobulin or Calcitonin or parathyroid hormone in paired and simultaneous thyroglobulin measurements of washout dilutions from 5/6 benign thyroid nodules and 2/5 metastatic lymph nodes...
June 2017: Endocrine
https://www.readbyqxmd.com/read/28377330/thyroglobulin-assay-in-fluids-from-lymph-node-fine-needle-aspiration-washout-influence-of-pre-analytical-conditions
#13
Florence Boux de Casson, Valérie Moal, Anne-Sophie Gauchez, Marie-Pierre Moineau, Corinne Sault, Marie-Hélène Schlageter, Catherine Massart
The aim of this study was to evaluate the pre-analytical factors contributing to uncertainty in thyroglobulin measurement in fluids from fine-needle aspiration (FNA) washout of cervical lymph nodes. We studied pre-analytical stability, in different conditions, of 41 samples prepared with concentrated solutions of thyroglobulin (FNA washout or certified standard) diluted in physiological saline solution or buffer containing 6% albumin. In this buffer, over time, no changes in thyroglobulin concentrations were observed in all storage conditions tested...
April 1, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/28327204/lung-adenocarcinoma-with-thyroid-metastasis-a-case-report
#14
A Dao, H Jabir, A Taleb, N Benchakroun, Z Bouchbika, T Nezha, H Jouhadi, S Sahraoui, A Benider
BACKGROUND: The metastases of a primary lung cancer over the thyroid gland are extremely rare. We report on an unusual presentation of thyroid metastasis of lung cancer in order to improve the management of similar cases. CASE PRESENTATION: Three years ago, a Moroccan male 59-year-old was admitted for dyspnea, dry cough, and chest pain. He had smoked about 30 cigarette packs a year. Clinical examination revealed a right thyroid nodule. Chest and neck computed tomography (CT) scan showed a proximal left tumor in contact with the pulmonary artery and revealed a suspected nodule in the right lobe of the thyroid with homolateral neck node...
March 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28225995/clinical-impact-of-thyroglobulin-tg-and-tg-autoantibody-tgab-measurements-in-needle-washouts-of-neck-lymph-node-biopsies-in-the-management-of-patients-with-papillary-thyroid-carcinoma
#15
M Cecilia Martins-Costa, Rui M B Maciel, Teresa S Kasamatsu, Claudia C D Nakabashi, Cleber P Camacho, Felipe Crispim, Elza S Ikejiri, M Conceição O Mamone, Danielle M Andreoni, Rosa Paula M Biscolla
Objectives: The presence of thyroglobulin (Tg) in needle washouts of fine needle aspiration biopsy (Tg-FNAB) in neck lymph nodes (LNs) suspected of metastasis has become a cornerstone in the follow-up of patients with papillary thyroid carcinoma (PTC). However, there are limited data regarding the measurement of anti-Tg antibodies in these washouts (TgAb-FNAB), and it is not clear whether these antibodies interfere with the assessment of Tg-FNAB or whether there are other factors that would more consistently justify the finding of low Tg-FNAB in metastatic LNs...
March 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28182063/frontal-bone-metastasis-from-an-occult-follicular-thyroid-carcinoma-diagnosed-by-fnac
#16
Rajnish Kalra, Richa Pawar, Sonia Hasija, Abha Chandna, Manoj Sankla, Chanchal Malhotra
Metastatic deposits in skull bones from follicular thyroid carcinoma is rare, and metastatic disease in skull being the presenting symptom without obvious thyroid lesion (occult primary) is even rarer. A 60-year-old female patient presented with a mass in the frontal region of the skull. Fine needle aspiration cytology was done which revealed an adenocarcinoma with repeated follicular pattern, reminiscent of follicular neoplasm of thyroid, which on immunocytochemistry revealed positivity for thyroglobulin. Patient was investigated further for primary thyroid malignancy, and imaging revealed a nodule in the left lobe of thyroid...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28040230/-cervical-thoracic-duct-cyst-an-uncommon-entity
#17
Manuel Carreira-Delgado, Elvira Fernández-Rodríguez, Marta Martínez-Míguez, María Jesús Álvarez-Martín, José Manuel Nuño Vázquez-Garza
BACKGROUND: Cervical thoracic duct cysts are a rare anomaly. OBJECTIVE: To report a case of cervical thoracic duct cyst, and perform a literature review. CLINICAL CASE: A 78-year-old female, with a one-year history of a left-sided asymptomatic supraclavicular cystic mass. Computerized tomography revealed a cystic mass 42mm in diameter. We performed a fine needle aspiration puncture, obtaining a thick, milky, whitish liquid. The patient underwent surgery; finding a left-sided supraclavicular cystic mass, with some lymph vessels heading towards the jugulo subclavian venous junction...
December 28, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/28003924/intrathyroidal-clear-cell-tumor-of-parathyroid-origin-with-review-of-literature
#18
Daniela Pirela, Daniela Treitl, Siba El Hussein, Robert Poppiti, Thomas Mesko, Alex Manzano
Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported in the literature, with only one of them being intrathyroidal. Here we report a case of a 34-year-old woman who presented for evaluation of a goiter and was found to have a thyroid nodule and abnormal thyroid function tests (TFT). Fine needle aspiration biopsy of the nodule revealed thyroid follicular cells without atypia and subsequent Afirma® Gene Expression Classifier (GEC) testing results were suspicious for malignancy...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27936964/preoperative-serum-thyroglobulin-and-changes-in-serum-thyroglobulin-during-tsh-suppression-independently-predict-follicular-thyroid-carcinoma-in-thyroid-nodules-with-a-cytological-diagnosis-of-follicular-lesion
#19
Hye Jeong Kim, Ji-Oh Mok, Chul Hee Kim, Yeo Joo Kim, Sang Jin Kim, Hyeong Kyu Park, Dong Won Byun, Kyoil Suh, Myung Hi Yoo
BACKGROUND: Fine-needle aspiration biopsy (FNAB) cannot distinguish a follicular thyroid carcinoma (FTC) from a follicular adenoma in follicular lesions. We designed this study to determine whether the preoperative thyroglobulin (Tg) and change in serum Tg during thyroid-stimulating hormone (TSH) suppression can predict FTC in thyroid nodules with a cytological diagnosis of follicular lesion. METHODS: Among 854 patients who underwent thyroid surgery, the 198 patients who presented with thyroid nodules with a cytological diagnosis of follicular lesion were analyzed...
May 2017: Endocrine Research
https://www.readbyqxmd.com/read/27899986/metastasis-of-renal-cell-carcinoma-to-the-parathyroid-gland-16-years-after-radical-nephrectomy-a-case-report
#20
Liborio Torregrossa, Maria Isabella Rotondo, Andrea Cacciato Insilla, David Galleri, Federica Guidoccio, Paolo Miccoli, Virginia A Livolsi, Fulvio Basolo
Renal cell carcinoma (RCC) has a high metastatic potential, and most commonly metastasizes via the bloodstream, although lymphatic metastases also occur. RCC is well-known for its propensity to metastasize to unusual sites, and late metastasis, even after a number of years, is common. The occurrence of RCC metastasis to the head and neck region is uncommon, and occurs primarily in the thyroid gland and in patients with widespread dissemination. Involvement of the parathyroid gland in metastatic carcinoma is extremely rare...
November 2016: Oncology Letters
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