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Fine needle aspiration and tg

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https://www.readbyqxmd.com/read/29785019/cribriform-morular-variant-of-thyroid-carcinoma-a-neoplasm-with-distinctive-phenotype-associated-with-the-activation-of-the-wnt-%C3%AE-catenin-pathway
#1
REVIEW
José Manuel Cameselle-Teijeiro, Diego Peteiro-González, Javier Caneiro-Gómez, María Sánchez-Ares, Ihab Abdulkader, Catarina Eloy, Miguel Melo, Isabel Amendoeira, Paula Soares, Manuel Sobrinho-Simões
Cribriform-morular variant of thyroid carcinoma is classically associated with familial adenomatous polyposis but, it can also occur as a sporadic neoplasm. This neoplasm is much more frequently observed in women than in men (ratio of 61:1). In familial adenomatous polyposis patients, tumors are generally multifocal and/or bilateral (multinodular appearance), whereas in the sporadic cases tumors tend to occur as single nodules. The tumors are well delimited, and characteristically show a blending of follicular, cribriform, papillary, trabecular, solid, and morular patterns...
May 21, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29783802/-clinicopathologic-and-molecular-features-of-cribriform-morular-variant-of-papillary-thyroid-carcinoma
#2
X J Cui, H O Zhao, P Su, J Chen, R Y Zhang, Y Pan, X M Ouyang, J Liu, J Q Zhang, Y Yang, R Yang, L Ding, Z Y Liu
Objective: To investigate the clinicopathologic and molecular features of the rare cribriform morular variant of papillary thyroid carcinoma (CMV-PTC). Methods: The clinicopathologic data of 10 patients with CMV-PTC were retrospectively reviewed. Immunohistochemical (IHC) staining was done using LSAB method. DNA sequencing for APC were applied using Sanger method. BRAF V600E mutation was examined using ARMS method. The cytological, morphological, IHC and molecular features were analyzed. Results: All patients were female at an average age of 27 years old...
May 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29776698/transoral-videolaryngoscopic-surgery-for-papillary-carcinoma-arising-in-lingual-thyroid
#3
Chisato Mogi, Hirotaka Shinomiya, Natsumi Fujii, Tomoyuki Tsuruta, Naruhiko Morita, Tatsuya Furukawa, Masanori Teshima, Maki Kanzawa, Mitsuyoshi Hirokawa, Naoki Otsuki, Ken-Ichi Nibu
Carcinoma arising in lingual thyroid is an extremely rare entity accounting for only 1% of all reported ectopic thyroids. Here, we report a case of carcinoma arising in lingual thyroid, which has been successfully managed by transoral resection and bilateral neck dissections. A lingual mass 4-cm in diameter with calcification was incidentally detected by computed tomography at medical check-up. No thyroid tissue was observed in normal position. Ultrasound examination showed bilateral multiple lymphadenopathies...
May 15, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29737627/papillary-carcinoma-in-thyroglossal-duct-cyst-diagnosis-by-fine-needle-aspiration-cytology-and-immunocytochemistry
#4
Dilip K Das, Smiley A George, Tareq Mohammad, Bency John, Sara S George, Abdulla I Behbehani
Carcinoma associated with thyroglossal duct cyst (TDC) is extremely rare and when it occurs it is invariably papillary carcinoma. A 36-year-old man presented with a midline swelling in the upper part of neck, which was a cystic lesion with multiple septae in ultrasonogram, indicating a thyroglossal duct cyst. The CT scan findings also corroborated the ultrasound report. Fine needle aspiration (FNA) smears showed hemosiderin laden cyst macrophages and occasional papillary cluster of neoplastic cells with central psammoma body and rare intranuclear cytoplasmic inclusions...
May 8, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29686910/cystic-lymphangioma-are-triglycerides-always-measurable
#5
Silke François, Manuella Martin, Olivier Costa, Daniel Urbain, Fazia Mana
The presence of chylous fluid with high triglycerides levels on endoscopic ultrasound- (EUS-) guided fine needle aspiration (FNA) is very pathognomonic for the diagnosis of cystic lymphangiomas of the pancreas. In our case report the puncture of the pancreatic cyst showed a typical milky fluid though measurable triglyceride concentrations were absent in the laboratory. Two possible explanations were found. First of all grossly lipemic samples show a slower rate of color development than do clear serums which can produce a false negative result if the sample is insufficiently diluted...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29675735/xanthogranulomatosis-of-the-spleen-a-case-report
#6
Goshi Fujimoto, Ken Hayashi, Shigetoshi Yamada, Hiroshi Kusanagi, Koichi Honma
BACKGROUND: Xanthogranulomatous inflammation is recognized as a subtype of cholecystitis; however, it can also occur in other organs. Xanthogranulomatosis of the kidney, bone, ovary, endometrium, vagina, prostate, lymph nodes and pancreas was reported. Herein, we report a case of laparoscopic splenectomy in a patient with xanthogranulomatosis of the spleen that was difficult to diagnose preoperatively. CASE PRESENTATION: A 63-year-old man with a past medical history of hyperlipidemia had gradually growing multiple splenic masses, which were revealed on abdominal ultrasonography...
April 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29624094/percutaneous-ethanol-injection-for-benign-cystic-and-mixed-thyroid-nodules
#7
A Ozderya, K Aydin, N Gokkaya, S Temizkan
BACKGROUND/AIM: We aimed to determine the effect of percutaneous ethanol injection (PEI) on volume of cystic and mixed thyroid nodules, thyroid function tests (TFTs), antibody titers and cytological changes for 1 year. METHODS: Fifty-five nodules of 53 patients with cystic and mixed properties treated with PEI were included. Nodule volumes, TFTs, thyroid autoantibodies were analyzed at baseline, 6th and 12th months. Fine needle aspiration biopsy (FNAB) was performed to PEI applied nodules in the 12th month...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29546779/thyroglobulin-measurement-in-the-management-of-patients-with-differentiated-thyroid-cancer
#8
Alicia Algeciras-Schimnich
The post-operative management of patients with differentiated thyroid carcinoma (DTC) relies on serial measurements of serum thyroglobulin. Current methodologies for thyroglobulin quantitation vary in their analytical and clinical performance. For years, thyroglobulin radioimmunoassays (RIA) and immunometric assays (IMA) have been used despite analytical interferences from anti-thyroglobulin autoantibodies (TgAb) as well as heterophile antibodies (HAb). TgAb interference limits Tg utility as a tumor marker in ∼30% of TgAb-positive patients...
May 2018: Critical Reviews in Clinical Laboratory Sciences
https://www.readbyqxmd.com/read/29524315/serum-calcitonin-negative-mixed-medullary-follicular-carcinoma-initially-diagnosed-as-medullary-thyroid-carcinoma-by-fine-needle-aspiration-cytology-a-case-report-and-review-of-the-literatures
#9
Yonghua Liu, Lin Yuan, Daohua Yang, Yubiao Jin
Medullary thyroid carcinoma (MTC) is potentially lethal. A prompt and accurate diagnosis is the prerequisite for the treatment of MTC. Fine-needle aspiration (FNA) is a reliable diagnostic tool in the assessment of thyroid nodules. However, cytologic assessment of MTC based on FNA has several drawbacks due to morphological variants. We present a case of MTC diagnosed through FNA cytology, which was eventually histologically confirmed as a mixed medullary-follicular carcinoma with negative serum calcitonin expression...
March 10, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29498919/lateral-neck-cystic-mass-the-role-of-thyroglobulin-measurement-in-fine-needle-aspiration
#10
Jamila A Benmoussa, Karin Chen, Saleh Nijjar, Megan Applewhite, James Warshaw
No abstract text is available yet for this article.
March 2, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29498418/papillary-thyroid-carcinoma-recurrence-low-yield-of-neck-ultrasound-with-an-undetectable-serum-thyroglobulin-level
#11
Samantha Epstein, Rachel McEachern, Rachita Khot, Shetal Padia, James T Patrie, Jason N Itri
OBJECTIVES: To assess the yield of neck ultrasound (US) when serum thyroglobulin (Tg) is undetectable (<0.1 ng/mL) compared to elevated serum Tg in patients with differentiated papillary thyroid carcinoma (PTC) treated with thyroidectomy and radioactive iodine 131 (RAI) ablation. METHODS: A retrospective chart review was conducted from 2010 through 2015 at an academic institution evaluating US results in patients with serum Tg levels obtained within 6 months of a neck US examination after thyroidectomy and RAI...
March 2, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29486536/non-invasive-quantification-of-hepatic-fat-content-in-healthy-dogs-using-proton-magnetic-resonance-spectroscopy-and-dual-gradient-echo-magnetic-resonance-imaging
#12
Francesca Del Chicca, Andrea Schwarz, Dieter Meier, Paula Grest, Annette Liesegang, Patrick Robert Kircher
Objective of the present study is to describe two non-invasive methods of fat quantification in the normal canine liver using magnetic resonance imaging and spectroscopy. Eleven adult beagle dogs were anesthetized and underwent magnetic resonance examination of the cranial abdomen including morphologic imaging, a modified Dixon (mDixon) dual gradient echo sequence and proton magnetic resonance spectroscopy (1 H MRS). In addition, ultrasonographic examination of the liver, fine needle aspirates and liver biopsies were performed, and hepatic triglyceride content was assayed...
February 27, 2018: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29477511/technical-note-evaluation-of-fine-needle-aspiration-cytology-for-the-diagnosis-of-fatty-liver-in-dairy-cattle
#13
P Melendez, M Whitney, F Williams, P Pinedo, D Manriquez, S G Moore, M C Lucy, P Pithua, S E Poock
Fatty liver is a common condition affecting dairy cattle during the periparturient period, characterized by a pathological accumulation of triglycerides (TG) in the hepatocytes. The objective of this study was to evaluate the diagnostic potential of fine needle aspiration cytology in fresh liver specimens using liver TG concentrations as a gold standard. Fifty-seven liver samples from Holstein cows were collected during processing at a slaughterhouse. Tissue and fine needle aspirate samples were obtained from the parietal upper portion of the caudate lobe...
May 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29337176/comparison-of-the-diagnostic-performances-of-ultrasonography-ct-and-fine-needle-aspiration-cytology-for-the-prediction-of-lymph-node-metastasis-in-patients-with-lymph-node-dissection-of-papillary-thyroid-carcinoma-a-retrospective-cohort-study
#14
Na Lae Eun, Eun Ju Son, Jeong-Ah Kim, Hye Mi Gweon, Jung-Hyun Kang, Ji Hyun Youk
PURPOSE: To evaluate the diagnostic performances of ultrasonographic (US) findings, computed tomography (CT) findings and fine needle aspiration cytology (FNAC) for the prediction of cervical lymph node (LN) metastases of papillary thyroid carcinoma (PTC) to determine which LN should be dissected. METHODS: 376 LNs in 302 patients who underwent both US-guided skin surface LN markings and CT before LN dissection were analyzed retrospectively. Indications for LN dissection were suspicious US findings of LN metastases (n = 300), suspicious CT findings (n = 67) or surgeon's request (n = 9)...
March 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29285211/molecular-analyses-of-prostate-tumors-for-diagnosis-of-malignancy-on-fine-needle-aspiration-biopsies
#15
Menglin Shan, Qianlin Xia, Dong Yan, Yanjun Zhu, Xuan Zhang, Guihong Zhang, Jianming Guo, Jun Hou, Weiping Chen, Tongyu Zhu, Xiaoyan Zhang, Jianqing Xu, Jin Wang, Tao Ding, Jianghua Zheng
Prostate cancer (PCa) is a common cancer and remains the second-leading cause of cancer-associated mortality in men, but diagnosis of PCa remains a main clinical challenge. To investigate the involvement of differentially expressing genes in PCa with deregulated pathways to allow earlier diagnosis of the disease, transcriptomic analyses of differential expression genes in fine-needle aspiration (FNA) biopsies helped to discriminate PCa from benign prostatic hyperplasia (BPH). We identified 255 genes that were deregulated in prostate tumors compared with BPH tissues...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29234622/impact-of-serum-tsh-and-anti-thyroglobulin-antibody-levels-on-lymph-node-fine-needle-aspiration-thyroglobulin-measurements-in-differentiated-thyroid-cancer-patients
#16
Marta Amaro da Silveira Duval, André Borsatto Zanella, Ana Patrícia Cristo, Carlo Sasso Faccin, Marcia Silva Graudenz, Ana Luiza Maia
Background: Thyroglobulin measurements in the washout of fine needle aspiration (FNA-Tg) are an excellent tool to detect lymph node (LN) metastases of differentiated thyroid carcinoma (DTC). Nevertheless, how to define the best cutoffs and the influence of potential confounders are still being discussed. Objective: To evaluate the accuracy of FNA-Tg measurement to detect DTC metastases and the influence of thyroid status and anti-thyroglobulin antibodies (TgAb)...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29228842/mammary-analogue-secretory-carcinoma-of-the-thyroid-mimicking-locally-advanced-papillary-thyroid-carcinoma-a-rare-case-report
#17
Haihui Liao, Ashraf Khan, Patricia M Miron, Kristine M Cornejo
Mammary analogue secretory carcinoma (MASC) harboring ETV6 gene rearrangements was first described in the salivary gland with a relatively favorable prognosis and a possible molecular therapeutic target with pan-Trk inhibitors. Recently, primary MASC of the thyroid gland has been reported. We report a case of a 4.0 cm MASC arising from the left thyroid of a 58-year-old female with extrathyroidal extension. Initially, it was diagnosed by fine needle aspiration as suspicious for papillary thyroid carcinoma (PTC) and subsequently called a poorly differentiated carcinoma on resection...
December 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29134304/outcome-of-thyroid-carcinoma-showing-thymus-like-differentiation-in-patients-undergoing-radical-resection
#18
Wenwu Dong, Ping Zhang, Jian Li, Liang He, Zhihong Wang, Ting Zhang, Liang Shao, Hao Zhang
BACKGROUND: Carcinoma showing thymus-like differentiation (CASTLE) is a rare malignant tumor of the thyroid. It is difficult to diagnose, and there is no universally recognized therapeutic regimen. This study aims to define the clinicopathological features and discuss the optimal management of CASTLE. METHODS: We retrospectively analyzed six patients with CASTLE who accepted surgery at the First Hospital of China Medical University between January 2010 and December 2015...
November 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29121688/long-term-follow-up-in-patients-with-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-without-a-suspicion-of-persistent-disease-in-postoperative-assessment
#19
Pedro Weslley Rosario, Gabriela Franco Mourão, Luís Fernando Faria Oliveira, Maria Regina Calsolari
The objective was to determine whether negative assessment after surgery is a predictor of no relevant change of the results in subsequent evaluations in patients with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Six months after surgery, "absence of persistent disease" was defined when concentration of thyroglobulin (Tg) is ≤2 ng/ml in patients undergoing total thyroidectomy and ≤10 ng/ml in those undergoing lobectomy, in the absence of antithyroglobulin antibodies (TgAb), and neck ultrasonography (US) without abnormalities...
March 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29017315/thyroid-cytology-the-japanese-system-and-experience-at-yamashita-thyroid-hospital
#20
REVIEW
Shinya Satoh, Hiroyuki Yamashita, Kennichi Kakudo
In Japan, fine-needle aspiration (FNA) cytology is the most important diagnostic modality for triaging patients with thyroid nodules. A clinician (endocrinologist, endocrine surgeon, or head and neck surgeon) generally performs FNA cytology at the outpatient clinic, and ultrasound (US)-guided FNA is widespread because US is extremely common and most clinicians are familiar with it. Although almost all FNA thyroid samples are examined by certified cytopathologists and pathologists, some clinicians assess cytological specimens themselves...
November 2017: Journal of Pathology and Translational Medicine
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