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JOURNAL ARTICLE
Robert Adamian, Paul McCleary, Toishi Sharma, David J Schneider
OBJECTIVES: FcɣRIIa amplifies platelet activation and greater expression increases platelet reactivity. In patients with myocardial infarction (MI), high platelet FcɣRIIa identifies patients with an approximately 4-fold greater risk of MI, stroke, and death. We compared platelet FcɣRIIa in 2 groups: (1) patients who had not had an MI in the previous year and were undergoing cardiac catheterization and percutaneous coronary intervention (PCI) labeled as stable coronary artery disease (CAD), and (2) previously obtained results in patients with MI (n = 197)...
February 2024: Journal of Invasive Cardiology
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JOURNAL ARTICLE
Ana Filipa da Silva Ferreira, Maria João Maia Azevedo, Juliana Pereira Morais, João Almeida-Coelho, André M Leite-Moreira, André P Lourenço, Francisca Almeida Saraiva, Sílvia Oliveira Diaz, Ana Filipa Amador, Carla Sousa, Ana Paula Machado, Benedita Sampaio Maia, Carla Maria de Almeida Ramalho, Adelino Leite-Moreira, António de Sousa Barros, Inês Falcão-Pires
INTRODUCTION: Pressure-overload-induced hypertrophy compromises cardiac stretch-induced compliance (SIC) after acute volume overload (AVO). We hypothesized that SIC could be enhanced by physiological hypertrophy induced by pregnancy's chronic volume overload. This study evaluated SIC-cardiac adaptation in pregnant women with or without cardiovascular risk (CVR) factors. METHODS: Thirty-seven (1st trimester, 1st T) and a separate thirty-one (3rd trimester, 3rd T) women (healthy or with CVR factors [obesity and/or hypertension and/or with gestational diabetes]) underwent echocardiography determination of left ventricular (LV) end-diastolic volume (LVEDV) and E/e' before (T0), immediately after (T1) and 15min after (T2; SIC) AVO induced by passive leg elevation...
February 9, 2024: American Journal of Physiology. Heart and Circulatory Physiology
#23
Roberto Lapetina Arroyo, Brian Monge Barrios, Hilton Franqui Rivera, Antonio Orraca Gotay, Amanda Marrero Gonzalez
BACKGROUND: The absence of the left atrial appendage is an exceedingly rare structural variant that could have important implications for anticoagulation regimens in patients with atrial fibrillation. CASE SUMMARY: We report the case of a 63-year-old Puerto Rican female with a history of hypertension, cerebral artery aneurysms, and type 2 diabetes mellitus who suffered multiple haemorrhagic strokes. The patient had never received anticoagulation therapy. During the indicated stroke work-up, the patient was found to have paroxysmal atrial fibrillation...
February 2024: European Heart Journal. Case Reports
#24
JOURNAL ARTICLE
Rufus O Akinyemi, Hemant K Tiwari, Vinodh Srinivasasainagendra, Onoja Akpa, Fred S Sarfo, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin O Osaigbovo, Olga A Mamaeva, Brian A Halloran, Joshua Akinyemi, Daniel Lackland, Olugbo Y Obiabo, Taofik Sunmonu, Innocent I Chukwuonye, Oyedunni Arulogun, Carolyn Jenkins, Abiodun Adeoye, Atinuke Agunloye, Okechukwu S Ogah, Godwin Ogbole, Adekunle Fakunle, Ezinne Uvere, Motunrayo M Coker, Akinkunmi Okekunle, Osahon Asowata, Samuel Diala, Mayowa Ogunronbi, Osi Adeleye, Ruth Laryea, Raelle Tagge, Sunday Adeniyi, Nathaniel Adusei, Wisdom Oguike, Paul Olowoyo, Olayinka Adebajo, Abimbola Olalere, Olayinka Oladele, Joseph Yaria, Bimbo Fawale, Philip Ibinaye, Olalekan Oyinloye, Yaw Mensah, Omotola Oladimeji, Josephine Akpalu, Benedict Calys-Tagoe, Hamisu A Dambatta, Adesola Ogunniyi, Rajesh Kalaria, Donna Arnett, Charles Rotimi, Bruce Ovbiagele, Mayowa O Owolabi
BACKGROUND: African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans. METHODS: Cases were consecutively recruited consenting adults (aged > 18 years) with neuroimaging-confirmed ischemic stroke...
February 5, 2024: Genome Medicine
#25
JOURNAL ARTICLE
Rupak Desai, Nishanth Katukuri, Sumaja Reddy Goguri, Azra Kothawala, Naga Ruthvika Alle, Meena Kumari Bellamkonda, Debankur Dey, Sharmila Ganesan, Minakshi Biswas, Kuheli Sarkar, Pramoda Prattipati, Shaylika Chauhan
BACKGROUND: Prediabetes is a well-established risk factor for major adverse cardiac and cerebrovascular events (MACCE). However, the relationship between prediabetes and MACCE in atrial fibrillation (AF) patients has not been extensively studied. Therefore, this study aimed to establish a link between prediabetes and MACCE in AF patients. AIM: To investigate a link between prediabetes and MACCE in AF patients. METHODS: We used the National Inpatient Sample (2019) and relevant ICD-10 CM codes to identify hospitalizations with AF and categorized them into groups with and without prediabetes, excluding diabetics...
January 15, 2024: World Journal of Diabetes
#26
JOURNAL ARTICLE
Merey Bakytzhanovna Jumagaliyeva, Dinmukhamed Nurniyazovich Ayaganov, Ibrahim Anwar Abdelazim, Samat Sagatovich Saparbayev, Nodira Miratalievna Tuychibaeva, Yergen Jumashevich Kurmambayev
The novel Coronavirus disease (COVID-19) is associated with an increased risk of cerebrovascular events. About 1,228 cases of severe COVID-19 were hospitalized in the West Kazakhstan Medical University Hospital, in Aktobe, Kazakhstan, 1.22% (N=15) of whom were clinically diagnosed with acute cerebrovascular events and were included in the current study. COVID-19 was diagnosed using a nasopharyngeal polymerase chain reaction (PCR) test, blood count, inflammatory markers, and chest computerized tomography. The diagnosis of acute cerebrovascular events was based on the clinical manifestation...
October 2023: Journal of Medicine and Life
#27
JOURNAL ARTICLE
H Nithesh Kumar, S Jeevanandham, Shankar Ganesh M, M Ashmi Sabana, P Manivasakam
Stroke-related cardiac death is a significant concern for patients with stroke and their healthcare providers. It is a complex and multifaceted condition that requires careful management of both modifiable and non-modifiable risk factors. This review provides an overview of the pathophysiology, risk factors, and prevention strategies for stroke-related cardiac death. The review highlights the importance of identifying and managing modifiable risk factors such as hypertension, diabetes, and lifestyle factors, as well as non-modifiable risk factors such as age and genetics...
January 19, 2024: Current Cardiology Reviews
#28
JOURNAL ARTICLE
Khalid S Ibrahim, Khalid A Kheirallah, Abdel Rahman A Al Manasra, Mahmoud A Megdadi
BACKGROUND: Different risk factors affect the intensive care unit (ICU) stay after cardiac surgery. This study aimed to evaluate these risk factors. PATIENTS AND METHODS: A retrospective analysis was conducted on clinical, operative, and outcome data from 1070 patients (mean age: 59 ± 9.8 years) who underwent isolated coronary bypass grafting CABG surgery with cardiopulmonary bypass. The outcome variable was prolonged length of stay LOS in the CICU stay (> 3 nights after CABG)...
February 3, 2024: Journal of Cardiothoracic Surgery
#29
JOURNAL ARTICLE
Mohamed S M Elshikhawoda, Sohaib Jararaa, Steven H S Tan, Ahmed Hashim Ahmed Mohamed, Doaa Abdalaziz Salih Abdalaziz, Abdillahi Ahmed Roble, Mahmoud Okaz, Waseem Ahmad, Abdelrhman Elsanosi, Hassan Jararah
Background Stroke is a prevalent ailment that impacts a substantial number of individuals globally, resulting in both physical impairment and mortality. One of its major causes is carotid artery stenosis. The symptoms and degree of stenosis are key indications for carotid endarterectomy (CEA). In this study, we highlight the indications and outcomes of carotid endarterectomy in our center. Methods This is a descriptive, retrospective, observational study. Data of patients who underwent CEA at Glan Clwyd Hospital from January 2018 to January 2023 was retrieved...
December 2023: Curēus
#30
JOURNAL ARTICLE
Eva Guldberg, Søren Zöga Diederichsen, Ketil Jørgen Haugan, Axel Brandes, Claus Graff, Derk Krieger, Morten Salling Olesen, Søren Højberg, Lars Køber, Niels Vejlstrup, Litten Bertelsen, Jesper Hastrup Svendsen
Epicardial adipose tissue (EAT) has endocrine and paracrine functions and has been associated with metabolic and cardiovascular disease. This study aimed to investigate the association between EAT, determined by cardiac magnetic resonance imaging (CMR), and incident atrial fibrillation (AF) following long-term continuous heart rhythm monitoring by implantable loop recorder (ILR). This study is a sub-study of the LOOP study. In total, 203 participants without a history of AF received an ILR and underwent advanced CMR...
January 21, 2024: International Journal of Cardiovascular Imaging
#31
JOURNAL ARTICLE
Hyo-Jeong Ahn, Hong Yul An, Gangpyo Ryu, Jiwoo Lim, Choonghyun Sun, Han Song, Su-Yeon Choi, Heesun Lee, Taylor Maurer, Daniel Nachun, Soonil Kwon, So-Ryoung Lee, Gregory Y H Lip, Seil Oh, Siddhartha Jaiswal, Youngil Koh, Eue-Keun Choi
BACKGROUND AND AIMS: Both clonal haematopoiesis of indeterminate potential (CHIP) and atrial fibrillation (AF) are age-related conditions. This study investigated the potential role of CHIP in the development and progression of AF. METHODS: Deep-targeted sequencing of 24 CHIP mutations (a mean depth of coverage = 1000×) was performed in 1004 patients with AF and 3341 non-AF healthy subjects. Variant allele fraction ≥ 2.0% indicated the presence of CHIP mutations...
January 17, 2024: European Heart Journal
#32
JOURNAL ARTICLE
Daniel M Huck, Brittany Weber, Brittany Schreiber, Jay Pandav, Sean Parks, Jon Hainer, Jenifer M Brown, Sanjay Divakaran, Ron Blankstein, Sharmila Dorbala, Ludovic Trinquart, Anil Chandraker, Marcelo F Di Carli
BACKGROUND: Advanced chronic kidney disease is associated with high cardiovascular risk, even after kidney transplant. Pretransplant cardiac testing may identify patients who require additional assessment before transplant or would benefit from risk optimization. The objective of the current study was to determine the relative prognostic utility of pretransplant positron emission tomography (PET) and single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) for posttransplant major adverse cardiovascular events (MACEs)...
January 2024: Circulation. Cardiovascular Imaging
#33
JOURNAL ARTICLE
Robert L Gauer, Joel M Guess
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in adults, with lifetime rates of 21% to 33%. There are numerous risk factors, including older age, hypertension, coronary disease, obstructive sleep apnea, diabetes, and others. Patients engaging in lifelong high-endurance exercise also have increased risk. Some organizations recommend screening; others do not. However, many patients identify AF themselves using mobile cardiac monitoring devices, some of which accurately detect the arrhythmia...
January 2024: FP Essentials
#34
JOURNAL ARTICLE
Tilmann Kramer, Phillip Nattmann, Felix Gerhardt, Patrycja Stafiej, Daniel Dumitrescu, Henrik Ten Freyhaus, Max Wißmüller, Christopher Hohmann, Stephan Baldus, Stephan Rosenkranz
AIMS: In pulmonary arterial hypertension (PAH), upfront combination therapy with ERA and PDE5i is associated with a reduction in morbidity and mortality events and improves standard haemodynamics, but data remain limited. Aims of this study were (i) to capture detailed haemodynamic effects of rapid sequential dual combination therapy in patients with newly diagnosed PAH; (ii) to monitor the impact of treatment initiation on clinical variables and patients' risk status, and (iii) to compare the treatment effect in patients with 'classical PAH' and 'PAH with co-morbidities'...
January 15, 2024: ESC Heart Failure
#35
JOURNAL ARTICLE
Kazuya Tateishi, Hosam Hmoud, Isabella De Gregorio, Ramin Hastings, Joseph De Gregorio
BACKGROUND: While females have been found to have a higher rate of procedural complications with transcatheter aortic valve implantation (TAVI) than males, the effect of valve choice has not been fully elucidated. This study aimed to investigate the impact of gender and choice of balloon or self-expanding valve on TAVI complications. METHODS: Data from patients who received a TAVI in our institution from January 2016 to September 2021 were retrospectively analyzed...
January 9, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#36
JOURNAL ARTICLE
Mengjin Hu, Tao Yang, Yuejin Yang
An inverse association of education level with cardiovascular diseases has been documented in observational studies, yet the causality and potential mechanisms remain to be determined. To systematically investigate the causal associations of education level with cardiovascular diseases, cardiovascular biomarkers, and socioeconomic factors, a 2-sample Mendelian randomization was performed. The results revealed that higher genetically determined education level was associated with lower risks of type 2 diabetes mellitus (odds ratio [OR] 0...
February 15, 2024: American Journal of Cardiology
#37
JOURNAL ARTICLE
Sleep apnea in end-stage renal disease patients: Impact on cardiovascular and neurological outcomes.
L Acree, J L Waller, W B Bollag, W J Healy, S L Baer, V Taskar
INTRODUCTION: Sleep apnea (SA) is an important comorbidity in end-stage renal disease (ESRD) patients. The association between SA and cardiac and neurological disease is known. This study investigates the relationship between SA and cardiovascular and cerebrovascular outcomes in the ESRD population. METHODS: In a retrospective cohort study, the United States Renal Data System was queried to identify ESRD patients aged 18-100 years in whom hemodialysis had been initiated between 2005 and 2013...
January 9, 2024: Journal of Postgraduate Medicine
#38
REVIEW
Rina Sha, Olivia Baines, Abbie Hayes, Katie Tompkins, Manish Kalla, Andrew P Holmes, Christopher O'Shea, Davor Pavlovic
Atrial fibrillation (AF) is the most common cardiac arrhythmia. AF increases the risk of stroke, heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both directly and indirectly, through related conditions, like hypertension, diabetes, and heart failure. Obesity-driven structural and electrical remodeling contribute to AF via several reported mechanisms, including adiposity, inflammation, fibrosis, oxidative stress, ion channel alterations, and autonomic dysfunction. In particular, expanding epicardial adipose tissue during obesity has been suggested as a key driver of AF via paracrine signaling and direct infiltration...
December 29, 2023: Journal of the American Heart Association
#39
JOURNAL ARTICLE
Zsuzsanna Németh, Miklós Siptár, Natália Tóth, Krisztina Tóth, Csaba Csontos, Zoltán Kovács-Ábrahám, Alexandra Csongor, Ferenc Molnár, Zsombor Márton, Sándor Márton
(1) Background and Objectives: Morbid obesity significantly increases the prevalence of comorbidities, such as heart disease, restrictive lung disease, stroke, diabetes mellitus and more. (2) Methods : Patients undergoing gastric sleeve surgery were divided into three groups with BMI between 30-34.9 kg/m2 (Group I), 35-39.9 kg/m2 (Group II), and over 40 kg/m2 (Group III). Preoperative examinations included cardiac ultrasound, respiratory function and laboratory tests, and preoperative comorbidities were also recorded...
November 29, 2023: Medicina
#40
JOURNAL ARTICLE
Satish Misra, Karen Niazi, Kamala Swayampakala, Amanda Blackmon, Melissa Lang, Elizabeth Davenport, Sherry Saxonhouse, John Fedor, Brian Powell, Joseph Thompson, John Holshouser, Rohit Mehta
BACKGROUND: Risk factor modification, in particular exercise and weight loss, has been shown to improve outcomes for patients with atrial fibrillation (AF). However, access to structured supporting programs is limited. Barriers include the distance from appropriate facilities, insurance coverage, work or home responsibilities, and transportation. Digital health technology offers an opportunity to address this gap and offer scalable interventions for risk factor modification. OBJECTIVE: This study aims to assess the feasibility and effectiveness of a 12-week asynchronous remotely supervised exercise and patient education program, modeled on cardiac rehabilitation programs, in patients with AF...
December 14, 2023: JMIR Cardio
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