keyword
https://read.qxmd.com/read/38515207/the-effect-of-selenium-supplementation-on-oxidative-stress-clinical-symptoms-and-mental-health-status-in-patients-with-migraine-a-study-protocol-for-a-double-blinded-randomized-clinical-trial
#21
JOURNAL ARTICLE
Arghavan Balali, Omid Sadeghi, Javad Anjom-Shoae, Mohammad Hossein Rouhani, Fariborz Khorvash, Gholamreza Askari
BACKGROUND: Despite a number of recommended strategies, effective treatment of migraine remains elusive. Given the role of oxidative stress in the pathogenesis of migraine, selenium, as an antioxidant nutrient, may have a beneficial effect on migraine outcomes. However, no study has explored the effects of selenium supplementation on migraine symptoms, oxidative stress biomarkers, and mental health. Therefore, this randomized, double-blinded, placebo-controlled clinical trial aims to examine the effects of selenium supplementation among migraine patients...
March 22, 2024: Trials
https://read.qxmd.com/read/38513779/a-metabolomics-approach-reveals-metabolic-disturbance-of-human-cholangiocarcinoma-cells-after-parthenolide-treatment
#22
JOURNAL ARTICLE
Yongping He, Qianxue Yu, Xiaoyu Ma, Diya Lv, Hui Wang, Weian Qiu, Xiao Fei Chen, Yang Jiao, Yue Liu
ETHNOPHARMACOLOGICAL RELEVANCE: Tanacetum parthenium (L.) Schultz-Bip, commonly known as feverfew, has been traditionally used to treat fever, migraines, rheumatoid arthritis, and cancer. Parthenolide (PTL), the main bioactive ingredient isolated from the shoots of feverfew, is a sesquiterpene lactone with anti-inflammatory and antitumor properties. Previous studies showed that PTL exerts anticancer activity in various cancers, including hepatoma, cholangiocarcinoma, acute myeloid leukemia, breast, prostate, and colorectal cancer...
March 19, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38512072/atp1a2-related-epileptic-encephalopathy-and-movement-disorder-clinical-features-of-three-novel-patients
#23
JOURNAL ARTICLE
Natalia Martínez Córdoba, Isabella Lince-Rivera, Jorge Luis Ramón Gómez, Guido Rubboli, Sebastián Ortiz De la Rosa
OBJECTIVE: Variants in the ATP1A2 gene exhibit a wide clinical spectrum, ranging from familial hemiplegic migraine to childhood epilepsies and early infantile developmental epileptic encephalopathy (EIDEE) with movement disorders. This study aims to describe the epileptology of three unpublished cases and summarize epilepsy features of the other 17 published cases with ATP1A2 variants and EIDEE. METHODS: Medical records of three novel patients with pathogenic ATP1A2 variants were retrospectively reviewed...
March 21, 2024: Epileptic Disorders: International Epilepsy Journal with Videotape
https://read.qxmd.com/read/38510106/5-ht-1f-receptor-agonism-induces-mitochondrial-biogenesis-and-increases-cellular-function-in-brain-microvascular-endothelial-cells
#24
JOURNAL ARTICLE
Natalie E Scholpa, Epiphani C Simmons, Austin D Thompson, Seth S Carroll, Rick G Schnellmann
INTRODUCTION: Vascular and mitochondrial dysfunction are well-established consequences of multiple central nervous system (CNS) disorders, including neurodegenerative diseases and traumatic injuries. We previously reported that 5-hydroxytryptamine 1F receptor (5-HT1F R) agonism induces mitochondrial biogenesis (MB) in multiple organ systems, including the CNS. METHODS: Lasmiditan is a selective 5-HT1F R agonist that is FDA-approved for the treatment of migraines...
2024: Frontiers in Cellular Neuroscience
https://read.qxmd.com/read/38508963/a-narrative-review-of-the-literature-relevant-to-obstetric-anesthesiologists-the-2023-gerard-w-ostheimer-lecture
#25
REVIEW
P Sultan
UNLABELLED: This narrative review of the 2023 Gerard W. Ostheimer lecture presented at the Society for Obstetric Anesthesia and Perinatology 2023 annual meeting summarizes 2022 literature relevant to obstetric anesthesiologists. ANTENATAL STUDIES: Neonatal morbidity is reduced with antenatal maternal buprenorphine compared with methadone for treatment of opioid use disorder. Antenatal pregnancy allergy testing is safe and feasible. ANALGESIA AND ANESTHESIA STUDIES: Intrathecal (IT) 3% chloroprocaine for cervical cerclage results in faster sensory block resolution and discharge readiness compared with bupivacaine...
January 3, 2024: International Journal of Obstetric Anesthesia
https://read.qxmd.com/read/38508838/genetics-of-migraine-complexity-implications-and-potential-clinical-applications
#26
REVIEW
Heidi G Sutherland, Bronwyn Jenkins, Lyn R Griffiths
Migraine is a common neurological disorder with large burden in terms of disability for individuals and costs for society. Accurate diagnosis and effective treatments remain priorities. Understanding the genetic factors that contribute to migraine risk and symptom manifestation could improve individual management. Migraine has a strong genetic basis that includes both monogenic and polygenic forms. Some distinct, rare, familial migraine subtypes are caused by pathogenic variants in genes involved in ion transport and neurotransmitter release, suggesting an underlying vulnerability of the excitatory-inhibitory balance in the brain, which might be exacerbated by disruption of homoeostasis and lead to migraine...
April 2024: Lancet Neurology
https://read.qxmd.com/read/38507402/healthcare-resource-utilization-and-associated-costs-among-patients-with-migraine-in-finland-a-retrospective-register-based-study
#27
JOURNAL ARTICLE
Mikko Kosunen, Jari Rossi, Severi Niskanen, Roope Metsä, Ville Kainu, Mari Lahelma, Outi Isomeri
Migraine is a common chronic brain disorder, characterized by recurring and often disabling attacks of severe headache, with additional symptoms such as photophobia, phonophobia and nausea. Migraine affects especially the working age population. The objective of this retrospective observational register-based study was to analyze the use of healthcare services and associated costs in Finnish migraine patients. Study was based on aggregate data from January 1st, 2020, to December 31st, 2021, from the Finnish Institute for Health and Welfare's national registries...
2024: PloS One
https://read.qxmd.com/read/38506767/effects-of-transcranial-direct-current-stimulation-on-clinical-outcomes-calcitonin-gene-related-peptide-and-pituitary-adenylate-cyclase-activating-polypeptide-38-levels-in-menstrual-migraine
#28
JOURNAL ARTICLE
Buse Rahime Hasırcı Bayır, Serkan Aksu, Haşim Gezegen, Zerrin Karaaslan, Hande Yüceer, Tuba Cerrahoğlu Şirin, Cem İsmail Küçükali, Adnan Kurt, Sacit Karamürsel, Vuslat Yılmaz, Betül Baykan
OBJECTIVES: Transcranial direct current stimulation (tDCS) has been suggested as an alternative treatment option for migraine. The present study aimed to evaluate the efficacy of tDCS on clinical outcomes in addition to calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide 38 (PACAP-38) levels in individuals with menstrual-related migraine (MRM) for the first time. MATERIALS AND METHODS: In this parallel study, 58 female patients between the ages of 18 and 45 years, including 36 with MRM and 22 with nonmenstrual migraines (nMM), were recruited...
March 19, 2024: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/38505499/efficacy-of-acupuncture-related-therapy-for-migraine-a-systematic-review-and-network-meta-analysis
#29
REVIEW
Yinqin Liu, Yan Wang, Chuanhao Mi, Ziyue Wang, Yu Han, Xianghua Qi, Xiao Ding
OBJECTIVE: Migraine is a common neurological disorder, which resulting in significant societal and personal burdens. Acupuncture has attracted widespread attention in migraine prophylaxis and treatment in recent years. Although some studies have confirmed the effectiveness of acupuncture therapy in treating migraines, there is still a lack of comprehensive evaluation regarding the comparison between different types of migraines and various acupuncture therapies. Furthermore, certain special acupuncture methods have not received sufficient attention and research...
2024: Journal of Pain Research
https://read.qxmd.com/read/38502436/yoga-for-migraine-prevention-an-ancient-practice-with-evidence-for-current-use
#30
REVIEW
Olivia Begasse de Dhaem, Carolyn Bernstein
PURPOSE OF REVIEW: The objective of this study is to review the recent literature on yoga for migraine prevention either as adjuvant or standalone therapy. Yoga is one of the most widely used complementary and integrative medicine (CIM) therapies; clinicians should be familiar with yoga practice so that they can best advise interested patients. It is also important to assess study design and types of yoga offered. Using PubMed and Litmaps, research published from 2018 to 2023 addressing yoga and migraine was assessed...
March 19, 2024: Current Pain and Headache Reports
https://read.qxmd.com/read/38502425/the-effect-of-lacosamide-on-calcitonin-gene-related-peptide-serum-level-in-episodic-migraine-patients-a-randomized-controlled-trial
#31
JOURNAL ARTICLE
Shimaa Elgamal, Sherihan Rezk Ahmed, Mohamed M Nahas, Shimaa R Hendawy, Osama Elshafei, Mohamed G Zeinhom
BACKGROUND: Migraine affects 11-15% of people worldwide, and the calcitonin gene-related peptide (CGRP) is released during the migraine attack, producing pulsating pain of migraine. Also, lacosamide reacts with collapsin-response mediator protein 2, preventing its phosphorylation and leading to the inhibition of CGRP release in the trigeminal system. OBJECTIVE: The primary outcome was the difference in the serum level of CGRP-LI after three months of treatment with either lacosamide and ibuprofen or ibuprofen alone in episodic migraine patients...
March 19, 2024: Acta Neurologica Belgica
https://read.qxmd.com/read/38502301/migraine-and-the-microbiota-can-probiotics-be-beneficial-in-its-prevention-a-narrative-review
#32
REVIEW
Aneta Kiecka, Marian Szczepanik
Migraine is a recurrent disease of the central nervous system that affects an increasing number of people worldwide causing a continuous increase in the costs of treatment. The mechanisms underlying migraine are still unclear but recent reports show that people with migraine may have an altered composition of the intestinal microbiota. It is well established that the gut-brain axis is involved in many neurological diseases, and probiotic supplementation may be an interesting treatment option for these conditions...
March 19, 2024: Pharmacological Reports: PR
https://read.qxmd.com/read/38500929/indian-consensus-on-the-role-of-amitriptyline-in-migraine-prophylaxis
#33
JOURNAL ARTICLE
Sumit Singh, A V Srinivasan, Tapas K Banerjee, Kanharam N Patel, Snehal S Muchhala, Bhavesh P Kotak
Migraine is a globally prevalent neurological disorder. Amitriptyline, a tricyclic antidepressant, has shown potential as a prophylactic treatment for migraine; however, its role as a first-line medication has been debated. A modified Delphi method was used to develop consensus statements on migraine and its management. The literature review identified knowledge gaps, and two survey rounds were conducted among a panel of experts. Consensus was reached for 12 out of 23 initial survey questions, whereas no consensus was reached for four questions after the deliberation in the second round...
February 2024: Curēus
https://read.qxmd.com/read/38499906/oxidative-stress-and-migraine
#34
REVIEW
Félix Javier Jiménez-Jiménez, Hortensia Alonso-Navarro, Elena García-Martín, Silvina Espada-Rubio, José A G Agúndez
The pathogenesis of migraine is not completely understood, but inflammation and oxidative stress seem to be involved, according to data from an experimental model of the disease. This narrative review summarizes data from studies on oxidative stress markers in migraine patients, case-control association studies on the possible association of candidate genes related to oxidative stress with the risk for migraine, studies showing the presence of oxidative stress in experimental models of migraine, and studies on the efficacy of antioxidant drugs in migraine therapy...
March 18, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38499208/a-12-week-randomized-double-blind-clinical-trial-of-eicosapentaenoic-acid-intervention-in-episodic-migraine
#35
JOURNAL ARTICLE
Hsueh-Fang Wang, Wen-Chun Liu, Halliru Zailani, Cheng-Chia Yang, Ting-Bin Chen, Ching-Mao Chang, I-Ju Tsai, Chun-Pai Yang, Kuan-Pin Su
Omega-3 polyunsaturated fatty acids (PUFAs) may benefit migraine improvement, though prior studies are inconclusive. This study evaluated the effect of eicosapentaenoic acid (EPA) on episodic migraine (EM) prevention. Seventy individuals with EM participated in a 12-week randomized, double-blind, placebo-controlled trial from March 2020 and May 2022. They were randomly assigned to either the EPA (N = 35, 2 g fish oil with 1.8 mg of EPA as a stand-alone treatment daily), or the placebo group (N = 35, 2 g soybean oil daily)...
March 16, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38499084/beyond-confirmed-mast-cell-activation-syndrome-approaching-patients-with-dysautonomia-and-related-conditions
#36
REVIEW
Alexandra E Conway, Marylee Verdi, Marcus S Shaker, Jonathan A Bernstein, Claire C Beamish, Richard Morse, Juliette Madan, Michael W Lee, Gordon Sussman, Amer Al-Nimr, Matthew Hand, Daniel A Albert
Allergist-immunologists face significant challenges as experts in an ever-evolving field of neuroimmunology. Among these challenges is the increasingly frequent need to counsel patients with suspected mast cell-activation disorders about perceived comorbidities, which may include hypermobile Ehlers Danlos syndrome, amplified pain syndrome, fibromyalgia, burning sensation syndromes, migraines, irritable bowel syndrome, and postural orthostatic tachycardia syndrome. Patients may experience comorbid anxiety, panic disorder and depression associated with disturbed sleep, fatigue, and cognitive impairment that often worsen when their physical symptoms increase in severity...
March 16, 2024: Journal of Allergy and Clinical Immunology in Practice
https://read.qxmd.com/read/38493795/global-regional-and-national-burden-of-disorders-affecting-the-nervous-system-1990-2021-a-systematic-analysis-for-the-global-burden-of-disease-study-2021
#37
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage...
March 5, 2024: Lancet Neurology
https://read.qxmd.com/read/38492426/sumatriptan-mitigates-bleomycin-induced-lung-fibrosis-in-male-rats-involvement-of-inflammation-oxidative-stress-and-%C3%AE-sma
#38
JOURNAL ARTICLE
Ayda Bahramifar, Razieh Mohammad Jafari, Mohammad Sheibani, Mohammad Amin Manavi, Amir Rashidian, Seyed Mohammad Tavangar, Mostafa Akbariani, Amirabbas Mohammadi Hamaneh, Ramin Goudarzi, Amir Shadboorestan, Ahmad Reza Dehpour
INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is a fibrotic lung condition that produces symptoms including coughing which may cause by excessive accumulation of scar tissue inflammatory and oxidative stress exacerbation. Sumatriptan, utilized for migraine treatment as a selective 5-HT1B/1D receptor agonist, has demonstrated significant anti-inflammatory and antioxidant properties in multiple preclinical investigations. Operating primarily on serotonin receptors, sumatriptan leverages the diverse physiological functions of serotonin, playing a pivotal role in regulating both inflammation and oxidative stress which is particularly relevant in the context of IPF...
March 12, 2024: Tissue & Cell
https://read.qxmd.com/read/38491460/is-erenumab-an-efficient-alternative-for-the-prevention-of-episodic-and-chronic-migraine-in-spain-results-of-a-cost-effectiveness-analysis
#39
JOURNAL ARTICLE
Patricia Pozo-Rosich, José Luis Poveda, Carlos Crespo, María Martínez, José Manuel Rodríguez, Pablo Irimia
BACKGROUND: The reimbursement of erenumab in Spain and other European countries is currently restricted because of the cost of this novel therapy to patients with migraine who have experienced previous failures to traditional preventive treatments. However, this reimbursement policy should be preferably based on cost-effectiveness studies, among other criteria. This study performed a cost-effectiveness analysis of erenumab versus topiramate for the prophylactic treatment of episodic migraine (EM) and versus placebo for chronic migraine (CM)...
March 15, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38491415/cgrp-monoclonal-antibodies-in-japan-insights-from-an-online-survey-of-physician-members-of-the-japanese-headache-society
#40
JOURNAL ARTICLE
Tsubasa Takizawa, Keiko Ihara, Narumi Watanabe, Ryo Takemura, Nobuyuki Takahashi, Naoki Miyazaki, Mamoru Shibata, Keisuke Suzuki, Noboru Imai, Norihiro Suzuki, Koichi Hirata, Takao Takeshima, Jin Nakahara
BACKGROUND: Anti-calcitonin gene-related peptide monoclonal antibodies (CGRPmAbs) have greatly changed migraine treatment options. In Japan, although CGRPmAb guidelines (≥ 4 monthly migraine days (MMDs) and ≥ 1 previous preventive failure) are well-acknowledged, the actual use of CGRPmAbs and the circumstances of the related headache care are unknown. METHODS: We conducted an online survey of Japanese Headache Society members, inquiring about the physicians' experience with CGRPmAbs and how they make decisions related to their use...
March 15, 2024: Journal of Headache and Pain
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