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Migraine and treatment

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https://www.readbyqxmd.com/read/29352859/is-selective-5-ht1f-receptor-agonism-an-entity-apart-from-that-of-the-triptans-in-antimigraine-therapy
#1
REVIEW
Eloísa Rubio-Beltrán, Alejandro Labastida-Ramírez, Carlos M Villalón, Antoinette MaassenVanDenBrink
Migraine is a neurovascular disorder that involves activation of the trigeminovascular system and cranial vasodilation mediated by release of calcitonin gene-related peptide (CGRP). The gold standard for acute migraine treatment are the triptans, 5-HT1B/1D/(1F) receptor agonists. Their actions are thought to be mediated through activation of: (i) 5-HT1B receptors in cranial blood vessels with subsequent cranial vasoconstriction; (ii) prejunctional 5-HT1D receptors on trigeminal fibers that inhibit trigeminal CGRP release; and (iii) 5-HT1B/1D/1F receptors in central nervous system involved in (anti)nociceptive modulation...
January 17, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29350303/a-short-review-of-the-non-invasive-transcutaneous-pericranial-electrical-stimulation-techniques-and-their-application-in-headache
#2
REVIEW
Licia Grazzi, Emanuela Sansone, Paul Rizzoli
PURPOSE OF REVIEW: In this short review, the most common non-invasive neuromodulatory techniques will be described, along with their advantages and disadvantages and their application in headache. Available preventive treatments can be unhelpful or may have unpleasant side effects; moreover, the rate of response to preventive drugs does not exceed 50%, lower in chronic migraine; alternative options would be welcome. Though the concept of neuromodulation was originally developed with invasive methods, newer non-invasive techniques are appearing...
January 19, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29350125/current-management-migraine-headache
#3
Stephen D Silberstein
Migraine varies in its frequency, severity, and impact; treatment should consider these variations and the patient's needs and goals. Migraine pharmacologic treatment may be acute (abortive) or preventive (prophylactic), and patients often require both. New medication devices are available or in development, including an intracutaneous, microneedle system of zolmitriptan and sumatriptan, and breath-powered powder sumatriptan intranasal treatment. Lasmiditan, a 5-HT1F receptor agonist, is in development for acute treatment, as are small molecule calcitonin gene-related peptide (CGRP) receptor antagonists (Gepants) for acute and preventive treatment...
December 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29350119/-medication-overuse-headache
#4
J A Pijpers, N J Wiendels, H Koppen, M D Ferrari, J Haan, G M Terwindt
- Medication-overuse headache is a highly prevalent disorder with a major impact on the quality of life.- Medication-overuse headache is defined as headache on ≥ 15 days per month with overuse of acute headache medication for ≥ 3 months. We talk about overuse in case of intake of simple analgesics on ≥ 15 days per month or triptans or combinations of analgesics on ≥ 10 days per month.- The underlying type of headache is usually migraine or tension-type headache.- One of the possible underlying mechanisms of medication-overuse headache is changed sensitivity as a consequence of central sensitisation...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29344989/salmon-calcitonin-ameliorates-migraine-pain-through-modulation-of-cgrp-release-and-dural-mast-cell-degranulation-in-rats
#5
Erkan Kilinc, Yasar Dagistan, Aysel Kukner, Bayram Yilmaz, Sami Agus, Gizem Soyler, Fatma Tore
The exact mechanism of migraine pathophysiology still remains unclear due to the complex nature of migraine pain. Salmon calcitonin (SC) exhibits antinociceptive effects in the treatment of various pain conditions. In this study, we explored the mechanisms underlying the analgesic effect of salmon calcitonin on migrane pain using glyceryltrinitrate(GTN)-induced model of migraine and ex-vivo meningeal preparations in rats. Rats were administered intraperitoneally saline, GTN(10mg/kg), vehicle, saline+GTN, SC(50μg/kg)+GTN, and SC alone...
January 18, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29341524/-what-s-new-in-ambulatory-general-internal-medicine%C3%A2
#6
Annick Gerber, Camille Buffle Genecand, Thierry Mach, David Schrumpf, Ana Rita Forte Marques, Jean Dupraz, Thomas Schmid
Many treatments are used every day in general medicine without any evidence of their efficacy. This last year, three randomised studies tried to prove the clinical utility of chondroitin/glucosamine in arthritis, cranberry in urinary infections, and acupuncture in migraine. Screening and management of prostate cancer are still controversial. Two recent studies help us advising our patients on this difficult topic. Muscle side effects from statins are well known and have been widely relayed by the press these last years, although myopathies are rare in clinical trials...
January 17, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29340791/treatment-of-disabling-headache-with-greater-occipital-nerve-injections-in-a-large-population-of-childhood-and-adolescent-patients-a-service-evaluation
#7
Francesca Puledda, Peter J Goadsby, Prab Prabhakar
BACKGROUND: Pediatric headache disorders can be extremely disabling, with marked reduction in the quality of life of children and their carers. Evidenced-based options for the treatment of primary headache disorders with preventive medication is limited and clinical outcomes are often unsatisfactory. Greater occipital nerve injections represent a rapid and well-tolerated therapeutic option, which is widely used in clinical practice in adults, and has previously shown a good outcome in a pediatric population...
January 16, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29340272/migraine-preventive-prescription-patterns-by-physician-specialty-in-ambulatory-care-settings-in-the-united-states
#8
Hiroko Takaki, Daisuke Onozuka, Akihito Hagihara
Many adults with migraine who require preventive therapy are often not prescribed the proper medications. The most likely reason is that primary care physicians are unacquainted with preventive medications for migraine. The present study assessed the migraine-preventive prescription patterns in office visits using data from the National Ambulatory Medical Care Survey from 2006 to 2009 in the United States. Patients who were 18 years or older and diagnosed with migraine were included in the analysis. In accordance with the recommendations of the headache guidelines, we included beta-blockers, antidepressants, triptans for short-term prevention of menstrual migraine, and other triptans for acute treatment...
March 2018: Preventive Medicine Reports
https://www.readbyqxmd.com/read/29338150/the-role-of-cannabinoids-in-pain-control-the-good-the-bad-and-the-ugly
#9
Joseph V Pergolizzi, Jo Ann Lequang, Robert Taylor, Robert B Raffa, Daniel Colucci
Cannabinoids appear to possess many potential medical uses, which may extend to pain control. A narrative review of the literature has found a variety of studies testing botanical and synthetic cannabinoids in different pain syndromes (acute pain, cancer pain, chronic noncancer pain, fibromyalgia pain, migraine, neuropathic pain, visceral pain, and others). Results from these studies are mixed; cannabinoids appear to be most effective in controlling neuropathic pain, allodynia, medication-rebound headache, and chronic noncancer pain, but do not seem to offer any advantage over nonopioid analgesics for acute pain...
January 16, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29337452/-neurology
#10
Isabelle Chopard, David Benninger, Jean-François Demonet, Renaud Du Pasquier, Lorenz Hirt, Thierry Kuntzer, Patrik Michel, Bernard Nater, Jan Novy, Andrea Rossetti, Olivier Rouaud, Philippe Ryvlin, Myriam Schluep, Marie Theaudin
Ocrelizumab (Ocrevus), an anti-CD20 monoclonal antibody, has been approved for the treatment of multiple sclerosis. Eculizumab (Soliris) has been approved in several countries for refractory forms of generalized seropositive severe myasthenia gravis. A form of gene therapy, patisiran, has shown positive results in transthyretin familial amyloidosis. In the treatment of headaches, particularly migraines, non-pharmacological approaches have shown some interesting results. The criteria for Lewy body dementia have been revised...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29336385/prophylaxis-of-postoperative-nausea-and-vomiting-after-cardiac-surgery-in-high-risk-patients-a-randomized-controlled-study
#11
Sébastien Champion, Laëtitia Zieger, Caroline Hemery
CONTEXT: The role of prophylaxis for postoperative nausea and vomiting (PONV) in cardiac surgery is under debate. AIMS: To study the risk factors for PONV after cardiac surgery and the role of betamethasone with or without droperidol for its prevention. SETTING AND DESIGN: Randomized open-label controlled study comparing standard care with PONV prophylaxis from February to November 2016. METHODS: Five hundred and two patients with planned nonemergent cardiac surgery were included...
January 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29334851/what-are-the-psychosocial-factors-associated-with-migraine-in-the-child-comorbid-psychiatric-disorders-family-functioning-parenting-style-or-mom-s-psychiatric-symptoms
#12
Gozde Kandemir, Selma Tural Hesapcioglu, Aysegül N Citak Kurt
OBJECTIVE: Psychiatric diagnoses, parenting style, family functioning among children and adolescents with migraine, and psychiatric symptoms of their mothers were examined. METHODS: The K-SADS and other measurements were used to assess psychiatric disorders in 50 children with migraine (aged 8-18) and matched 50 controls. RESULTS: At least one psychiatric disorder was diagnosed in 56% of the migraine group. The presence of any psychiatric disorder in children (odds ratio [OR] = 2...
February 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29333870/the-effects-of-aerobic-exercise-for-persons-with-migraine-and-co-existing-tension-type-headache-and-neck-pain-a-randomized-controlled-clinical-trial
#13
Lotte Skytte Krøll, Catharina Sjödahl Hammarlund, Mattias Linde, Gunvor Gard, Rigmor Højland Jensen
Aim To evaluate aerobic exercise in migraine and co-existing tension-type headache and neck pain. Methods Consecutively recruited persons with migraine and co-existing tension-type headache and neck pain were randomized into an exercise group or control group. Aerobic exercise consisted of bike/cross-trainer/brisk walking for 45 minutes, three times/week. Controls continued usual daily activities. Pain frequency, intensity, and duration; physical fitness, level of physical activity, well-being and ability to engage in daily activities were assessed at baseline, after treatment and at follow-up...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29323926/investigating-effects-of-sex-differences-and-prior-concussions-on-symptom-reporting-and-cognition-among-adolescent-soccer-players
#14
Brian L Brooks, Noah Silverberg, Bruce Maxwell, Rebekah Mannix, Ross Zafonte, Paul D Berkner, Grant L Iverson
BACKGROUND: There has been increasing concern regarding the possible effect of multiple concussions on the developing brain, especially for adolescent females. Hypothesis/Purpose: The objectives were to determine if there are differences in cognitive functioning, symptom reporting, and/or sex effects from prior concussions. In a very large sample of youth soccer players, it was hypothesized that (1) there would be no differences in cognitive test performance between those with and without prior concussions, (2) baseline preseason symptoms would be better predicted by noninjury factors than concussion history, and (3) males and females with prior concussions would not have differences in cognition or symptoms...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29322494/common-primary-and-secondary-causes-of-headache-in-the-elderly
#15
Tara L Sharma
OBJECTIVE/BACKGROUND: Headache in the elderly, defined as individuals aged 65 and older, although less prevalent than younger individuals, can present as a diagnostic challenge, given the increase in potentially fatal diseases within this population. METHODS: These individuals require a complete history, neurological examination, and assessment of potential secondary causes of headaches. RESULTS: Secondary causes include temporal or giant cell arteritis, subdural hematomas, central nervous system (CNS) tumors, strokes, and CNS infections...
January 11, 2018: Headache
https://www.readbyqxmd.com/read/29313274/correction-to-migraine-treatment-current-acute-medications-and-their-potential-mechanisms-of-action
#16
Jonathan Jia Yuan Ong, Milena De Felice
This article was updated to correct an error in figure 1 introduced during the production process.
January 8, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29310444/safety-of-galcanezumab-in-patients-with-episodic-migraine-a-randomized-placebo-controlled-dose-ranging-phase-2b-study
#17
Tina Marie Myers Oakes, Vladimir Skljarevsuki, Qi Zhang, William Kielbasa, Michael E Hodsdon, Holland C Detke, Angelo Camporeale, Joel R Saper
Background Safety findings from a Phase 2b study of galcanezumab, a humanized monoclonal antibody against calcitonin gene-related peptide, for prevention of migraine (NCT02163993) are reported here. Methods Patients aged 18-65 years with episodic migraine were evaluated in this multicenter, double-blind, randomized study. After randomization, 410 patients were administered 5, 50, 120 or 300 mg of galcanezumab or placebo subcutaneously once every 4 weeks for 12 weeks, followed by a post-treatment off-drug period lasting 12 weeks...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29306250/topographic-methods-to-expose-the-exiting-points-of-supratrochlear-supraorbital-and-zygomaticotemporal-nerves
#18
Mesut Sabri Tezer, İsmail Yağmurhan Gilan, Özlem Elvan, Vedia Bennu Özcömert, Mustafa Aktekin
Background/aim: We evaluated the relations of the exiting points of supratrochlear (STN), supraorbital (SON), and zygomaticotemporal (ZTN) nerves with certain landmarks to provide improved anatomic knowledge. Materials and methods: The twenty-eight hemifaces of 5 fresh frozen and 11 embalmed heads (5 female and 11 male cadavers) were dissected. Distance and angular measurements were made between the exiting points of the nerves to the midline, lateral, and medial canthi. Comparisons of side, sex, and cadaver groups were evaluated...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29304243/hyperexcitability-of-the-central-nervous-system-in-children-with-chronic-pain-a-systematic-review
#19
Roselien Pas, Kelly Ickmans, Sophie Van Oosterwijck, Kelly Van der Cruyssen, Anthe Foubert, Laurence Leysen, Jo Nijs, Mira Meeus
Objective: Hyperexcitability of the central nervous system plays an important role in the development and maintenance of chronic pain in adults. This knowledge has led to improved treatment strategies within this population. In children, however, research on the presence of central hyperexcitability is scarce. To further investigate this topic in children with chronic pain, there is a need for a clear literature overview. Design: Systematic review. Methods: The literature search was performed using the electronic databases PubMed and Web of Science...
January 2, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29303124/prevalence-and-clinical-characteristics-of-headaches-among-undergraduate-students-in-three-tertiary-institutions-in-ilorin-nigeria
#20
E O Sanya, O O Desalu, S A Aderibigbe, P M Kolo, A F Mustapha, O A Adeyanju
OBJECTIVE: Headache is a common chronic neurologic disorder with huge economic and psychosocial impact. In comparison with other neurological disorders, there is limited data on primary headache, especially from sub-Saharan Africa. This study was done to fill in the gap and provide recent information on headache among Nigerian undergraduate students. METHODOLOGY: Quota sampling was used to select students from three tertiary educational institutions within Ilorin, the capital of Kwara state...
November 2017: Nigerian Journal of Clinical Practice
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