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https://www.readbyqxmd.com/read/29054020/unraveling-the-mechanisms-behind-iron-overload-and-ineffective-hematopoiesis-in-myelodysplastic-syndromes
#1
REVIEW
Emanuele Angelucci, Paolo Cianciulli, Carlo Finelli, Cristina Mecucci, Maria Teresa Voso, Sante Tura
Myelodysplastic syndromes (MDS) are a group of clonally-acquired blood disorders characterized by ineffective hematopoiesis leading to cytopenias. Red blood cell transfusions are an important component of supportive care in patients with MDS. Prolonged exposure to transfusions can lead to iron overload, which results in iron-induced toxicity caused by the production of reactive oxygen species (ROS). ROS accumulation has detrimental effects also on hematopoietic stem cells and may contribute to MDS progression...
October 5, 2017: Leukemia Research
https://www.readbyqxmd.com/read/29050007/comparison-of-safety-and-efficacy-of-tacrolimus-versus-infliximab-for-active-ulcerative-colitis
#2
Ken Takeuchi, Takahiro Shimoyama, Takayuki Yamamoto
BACKGROUND: This narrative review was to determine which medication, tacrolimus (TAC) or infliximab (IFX), is safer and more effective in the management of active UC. Our literature search identified 5 studies directly comparing the outcomes of TAC versus IFX for active UC. A review of the 5 studies was undertaken. SUMMARY: The incidence of serious adverse events was not significantly different between the TAC and IFX groups. The short-term clinical remission and response rates and the colectomy-free rates were similar between the groups...
October 19, 2017: Digestive Diseases
https://www.readbyqxmd.com/read/29049840/evaluating-interest-in-narrative-therapy-for-decision-making-about-pectus-excavatum-treatment
#3
Davide Ticchi, Robert S Eisinger, Hans K Pilegaard, Michele Torre, Sergio B Sesia, Maurizio Infante, Emanuele Voulaz, Mauricio Arce Quesada, Merike Sisask
OBJECTIVES: The decision to proceed with surgical treatment for pectus excavatum (PE) is rarely clear-cut. Patients interested in treatment are referred for evaluation by numerous different specialists, but psychosocial counselling is currently not included in this process. Our objective was to assess whether PE patients would be interested in formal assistance with the decision-making process surrounding PE surgery using narrative therapy principles. METHODS: Ninety-seven untreated PE patients at 5 different institutions in 4 countries completed a questionnaire consisting of 13 questions, with 3 questions specifically evaluating interest in narrative therapy...
September 26, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049120/a-contemporary-medicolegal-analysis-of-outpatient-medication-management-in-chronic-pain
#4
Christopher R Abrecht, Ethan Y Brovman, Penny Greenberg, Ellen Song, James P Rathmell, Richard D Urman
BACKGROUND: Opioids are frequently used in chronic pain management but are associated with significant morbidity and mortality in some patient populations. An important avenue for identifying complications-including serious or rare complications-is the study of closed malpractice claims. The present study is intended to complement the existing closed claims literature by drawing on claims from a more recent timeframe through a partnership with a large malpractice carrier, the Controlled Risk Insurance Company (CRICO)...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29049114/alternatives-to-opioids-in-the-pharmacologic-management-of-chronic-pain-syndromes-a-narrative-review-of-randomized-controlled-and-blinded-clinical-trials
#5
Andrea L Nicol, Robert W Hurley, Honorio T Benzon
Chronic pain exerts a tremendous burden on individuals and societies. If one views chronic pain as a single disease entity, then it is the most common and costly medical condition. At present, medical professionals who treat patients in chronic pain are recommended to provide comprehensive and multidisciplinary treatments, which may include pharmacotherapy. Many providers use nonopioid medications to treat chronic pain; however, for some patients, opioid analgesics are the exclusive treatment of chronic pain...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29046662/shared-medical-appointments-may-be-effective-for-improving-clinical-and-behavioral-outcomes-in-type-2-diabetes-a-narrative-review
#6
REVIEW
Kirthi Menon, Aya Mousa, Maximilian Pj de Courten, Georgia Soldatos, Garry Egger, Barbora de Courten
Type 2 diabetes mellitus (T2DM) is a complex chronic disease affecting over 400 million people worldwide. Managing T2DM and its associated complications in individual patient consultations poses substantial challenges to physicians due to limited time and resources and lack of access to multidisciplinary teams. Shared medical appointments (SMAs) are consecutive medical consultations provided by a physician in a group setting, where integrated medical care and patient education are delivered in a single session...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29046154/neural-network-alterations-across-eating-disorders-a-narrative-review-of-fmri-studies
#7
Trevor Steward, José M Menchón, Susana Jiménez-Murcia, Carles Soriano-Mas, Fernando Fernández-Aranda
Functional magnetic resonance imaging (fMRI) has provided insight on how neural abnormalities are related to the symptomatology of the eating disorders (EDs): anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). More specifically, an increasingly growing number of brain imaging studies has shed light on how functionally connected brain networks contribute not only to disturbed eating behavior, but also to transdiagnostic alterations in body/interoceptive perception, reward processing and executive functions...
October 17, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29045915/acute-psychoactive-effects-of-intravenous-ketamine-during-treatment-of-mood-disorders-analysis-of-the-clinician-administered-dissociative-state-scale
#8
Gerrit I van Schalkwyk, Samuel T Wilkinson, Larry Davidson, Wendy K Silverman, Gerard Sanacora
INTRODUCTION: Ketamine has rapid-acting antidepressant effects. Frequently, ketamine administration also causes acute psychoactive effects - in trials, these effects are commonly measured using the Clinician Administered Dissociative State Scale (CADSS). However, the CADSS was not designed for this specific purpose, having been validated in other clinical contexts, and anecdotally does not appear to fully capture ketamine's acute psychoactive effects. METHODS: Data were obtained from 110 individuals with mood disorders (predominantly major depressive disorder) who underwent intravenous ketamine infusion...
September 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29045622/international-exchanges-in-primary-care-learning-from-thy-neighbour
#9
Bernadeta Bridgwood, John Park, Claire Hawcroft, Natasha Kay, Eugene Tang
This systematic review describes how international exchange programmes in primary care have been received and evaluated. Electronic databases (MEDLINE, Embase, PsycINFO, EBM reviews, CAB abstracts and PubMED) were searched to identify articles where the main focus of the study was exchanges undertaken in primary care/family medicine until March 2016. Articles were included if they (i) discussed participant exchanges in primary care; (ii) presented associated outcome data-this included (a) individual/group experience of exchange; (b) mechanism of exchange and (c) observations during the exchange...
October 14, 2017: Family Practice
https://www.readbyqxmd.com/read/29044675/-oh-my-god-i-can-t-handle-this-trainees-emotional-responses-to-complex-situations
#10
Esther Helmich, Laura Diachun, Radha Joseph, Kori LaDonna, Nelleke Noeverman-Poel, Lorelei Lingard, Sayra Cristancho
CONTEXT: Dealing with emotions is critical for medical trainees' professional development. Taking a sociocultural and narrative approach to understanding emotions, we studied complex clinical situations as a specific context in which emotions are evoked and influenced by the social environment. We sought to understand how medical trainees respond to emotions that arise in those situations. METHODS: In an international constructivist grounded theory study, 29 trainees drew two rich pictures of complex clinical situations, one exciting and one frustrating...
October 16, 2017: Medical Education
https://www.readbyqxmd.com/read/29044493/combining-echo-and-natriuretic-peptides-to-guide-heart-failure-care-in-the-outpatient-setting-a-position-paper
#11
REVIEW
Frank Lloyd Dini, Erberto Carluccio, Fabrizio Montecucco, Gian Marco Rosa, Paolo Fontanive
BACKGROUND: Chronic heart failure (HF) is a relevant and growing public health problem. Although the prognosis has recently improved, it remains a lethal disease, with a mortality that equals or exceeds that of many malignancies. Furthermore, chronic HF is costly, representing a large and growing drain on healthcare resources. METHODS: This narrative review is based on the material searched for and obtained via PubMed up to May 2017. The search terms we used were: "heart failure, echocardiography, natriuretic peptides" in combination with "treatment, biomarkers, guidelines"...
October 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29042693/occult-sources-of-bleeding-in-blunt-trauma-a-narrative-review
#12
REVIEW
Tetsuya Yumoto, Yoshinori Kosaki, Yasuaki Yamakawa, Atsuyoshi Iida, Hirotsugu Yamamoto, Taihei Yamada, Kohei Tsukahara, Hiromichi Naito, Takaaki Osako, Atsunori Nakao
Worldwide, hemorrhagic shock in major trauma remains a major potentially preventable cause of death. Controlling bleeding and subsequent coagulopathy is a big challenge. Immediate assessment of unidentified bleeding sources is essential in blunt trauma patients with hemorrhagic shock. Chest/pelvic X-ray in conjunction with ultrasonography have been established classically as initial diagnostic imaging modalities to identify the major sources of internal bleeding including intra-thoracic, intra-abdominal, or retroperitoneal hemorrhage related to pelvic fracture...
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29042377/effectiveness-and-meaningful-use-of-paediatric-surgical-safety-checklists-and-their-implementation-strategies-a-systematic-review-with-narrative-synthesis
#13
Janaka Lagoo, Steven R Lopushinsky, Alex B Haynes, Paul Bain, Helene Flageole, Erik D Skarsgard, Mary E Brindle
OBJECTIVE: To examine the effectiveness and meaningful use of paediatric surgical safety checklists (SSCs) and their implementation strategies through a systematic review with narrative synthesis. SUMMARY BACKGROUND DATA: Since the launch of the WHO SSC, checklists have been integrated into surgical systems worldwide. Information is sparse on how SSCs have been integrated into the paediatric surgical environment. METHODS: A broad search strategy was created using Pubmed, Embase, CINAHL, Cochrane Central, Web of Science, Science Citation Index and Conference Proceedings Citation Index...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29038985/showing-the-unsayable-participatory-visual-approaches-and-the-constitution-of-patient-experience-in-healthcare-quality-improvement
#14
Constantina Papoulias
This article considers the strengths and potential contributions of participatory visual methods for healthcare quality improvement research. It argues that such approaches may enable us to expand our understanding of 'patient experience' and of its potential for generating new knowledge for health systems. In particular, they may open up dimensions of people's engagement with services and treatments which exceed both the declarative nature of responses to questionnaires and the narrative sequencing of self reports gathered through qualitative interviewing...
October 16, 2017: Health Care Analysis: HCA: Journal of Health Philosophy and Policy
https://www.readbyqxmd.com/read/29038682/depression-as-a-moderator-of-stair-narrative-therapy-for-women-with-post-traumatic-stress-disorder-related-to-childhood-abuse
#15
Marylene Cloitre, Donn W Garvert, Brandon J Weiss
Background: Depression among those who have experienced childhood abuse is associated with earlier onset, more persistent and severe symptoms, more frequent relapse, and poorer treatment outcomes across a variety of psychiatric disorders. In addition, individuals with a history of childhood abuse are more likely to develop post-traumatic stress disorder (PTSD) co-occurring with depression. Objective: This study evaluated whether severity of depression moderated the outcome in a PTSD treatment for childhood abuse survivors...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29036629/nanotechnology-a-promising-new-paradigm-for-the-control-of-pain
#16
Krishnan V Chakravarthy, Frank J Boehm, Paul J Christo
Objective: The objective of this article is to critically review both preclinical and clinical studies that focus on the use of nanotechnology for both acute and chronic pain management, surveying both diagnostic and therapeutic applications. The article also provides information on nanotechnology for pain practitioners, so that they may better understand how this technology works and how it may be applied to their day-to-day clinical practice. Study Design: Narrative review...
June 27, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29035966/effectiveness-of-rifampicin-chemoprophylaxis-in-preventing-leprosy-in-patient-contacts-a-systematic-review-of-quantitative-and-qualitative-evidence
#17
Silvana Margarida Benevides Ferreira, Tatiana Yonekura, Eliane Ignotti, Larissa Bertacchini de Oliveira, Juliana Takahashi, Cassia Baldini Soares
BACKGROUND: Individuals in contact with patients who have leprosy have an increased risk of disease exposure, which reinforces the need for chemoprophylactic measures, such as the use of rifampicin. OBJECTIVES: The objective of the review was to synthesize the best available evidence regarding the effectiveness of rifampicin chemoprophylaxis for contacts with patients with leprosy, and to synthesize the best available evidence on the experience and acceptability of rifampicin chemoprophylaxis as reported by the contacts and health professionals involved in the treatment of leprosy or Hansen's disease...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035696/the-reliability-of-surgical-apgar-score-in-predicting-immediate-and-late-postoperative-morbidity-and-mortality-a-narrative-review
#18
Abhijit Nair, Aanchal Bharuka, Basanth Kumar Rayani
Surgical Apgar Score is a simple, 10-point scoring system in which a low score reliably identifies those patients at risk for adverse perioperative outcomes. Surgical techniques and anesthesia management should be directed in such a way that the Surgical Apgar Score remains higher to avoid postoperative morbidity and mortality.
October 13, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/29035184/the-art-of-healing-through-narrative-medicine-in-clinical-practice-a-reflection
#19
Aeman Muneeb, Hena Jawaid, Natasha Khalid, Asad Mian
The art of medicine has roots that lie deep in developing the biopsychosocial connection. Understanding a human body (both its physiology and pathology) along with components of emotional and spiritual cores can lead to provision of excellent medical care and better outcomes. The harmonization of psychosocial consequences of a biological disease is helpful not just for health care professionals but also for patients. Where it keeps the empathy and compassion alive and results in greater patient satisfaction, it also helps boost the physician's morale...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29034802/unraveling-the-mechanisms-of-manual-therapy-modeling-an-approach
#20
Joel E Bialosky, Jason M Beneciuk, Mark D Bishop, Rogelio A Coronado, Charles W Penza, Corey B Simon, Steven Z George
Synopsis Manual therapy interventions are popular among individual healthcare providers and their patients; however, systematic reviews do not strongly support their effectiveness. Small treatment effect sizes of manual therapy interventions may result from a "one size fits all" approach to treatment. Mechanistic based treatment approaches to manual therapy offer an intriguing alternative for identifying patients likely to respond to manual therapy. However, the current lack of knowledge of the mechanisms through which manual therapy interventions inhibit pain limits such an approach...
October 15, 2017: Journal of Orthopaedic and Sports Physical Therapy
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