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https://www.readbyqxmd.com/read/28319173/affinity-purification-of-human-m-calpain-through-an-intrinsically-disordered-inhibitor-calpastatin
#1
Hung Huy Nguyen, Mihaly Varadi, Peter Tompa, Kris Pauwels
Calpains are calcium-activated proteases that have biomedical and biotechnological potential. Their activity is tightly regulated by their endogenous inhibitor, calpastatin that binds to the enzyme only in the presence of calcium. Conventional approaches to purify calpain comprise multiple chromatographic steps, and are labor-intensive, leading to low yields. Here we report a new purification procedure for the human m-calpain based on its reversible calcium-mediated interaction with the intrinsically disordered calpastatin...
2017: PloS One
https://www.readbyqxmd.com/read/28293882/method-for-developing-optical-sensors-using-a-synthetic-dye-fluorescent-protein-fret-pair-and-computational-modeling-and-assessment
#2
Joshua A Mitchell, William H Zhang, Michel K Herde, Christian Henneberger, Harald Janovjak, Megan L O'Mara, Colin J Jackson
Biosensors that exploit Förster resonance energy transfer (FRET) can be used to visualize biological and physiological processes and are capable of providing detailed information in both spatial and temporal dimensions. In a FRET-based biosensor, substrate binding is associated with a change in the relative positions of two fluorophores, leading to a change in FRET efficiency that may be observed in the fluorescence spectrum. As a result, their design requires a ligand-binding protein that exhibits a conformational change upon binding...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28223522/conformational-dynamics-of-a-neurotransmitter-sodium-symporter-in-a-lipid-bilayer
#3
Suraj Adhikary, Daniel J Deredge, Anu Nagarajan, Lucy R Forrest, Patrick L Wintrode, Satinder K Singh
Neurotransmitter:sodium symporters (NSSs) are integral membrane proteins responsible for the sodium-dependent reuptake of small-molecule neurotransmitters from the synaptic cleft. The symporters for the biogenic amines serotonin (SERT), dopamine (DAT), and norepinephrine (NET) are targets of multiple psychoactive agents, and their dysfunction has been implicated in numerous neuropsychiatric ailments. LeuT, a thermostable eubacterial NSS homolog, has been exploited as a model protein for NSS members to canvass the conformational mechanism of transport with a combination of X-ray crystallography, cysteine accessibility, and solution spectroscopy...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28216797/disability-benefit-generosity-and-labor-force-withdrawal
#4
Kathleen J Mullen, Stefan Staubli
A key component for estimating the optimal size and structure of disability insurance (DI) programs is the elasticity of DI claiming with respect to benefit generosity. Yet, in many countries, including the United States, all workers face identical benefit schedules, which are a function of one's labor market history, making it difficult to separate the effect of the benefit level from the effect of unobserved preferences for work on individuals' claiming decisions. To circumvent this problem, we exploit exogenous variation in DI benefits in Austria arising from several reforms to its DI and old age pension system in the 1990s and 2000s...
November 2016: Journal of Public Economics
https://www.readbyqxmd.com/read/28182999/employment-effects-of-active-labor-market-programs-for-sick-listed-workers
#5
Anders Holm, Jan Høgelund, Mette Gørtz, Kristin Storck Rasmussen, Helle Sofie Bøje Houlberg
We use register data of 88,948 sick-listed workers in Denmark over the period 2008-2011 to investigate the effect of active labor market programs on the duration until returning to non-subsidized employment and the duration of this employment. To identify causal treatment effects, we exploit over-time variation in the use of active labor market programs in 98 job centers and time-to- event. We find that ordinary education and subsidized job training have significant positive employment effects. Subsidized job training has a large, positive effect on the transition into employment but no effect on the subsequent employment duration...
January 30, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28174202/ethics-rounds-ethical-concerns-when-minors-act-as-standardised-patients
#6
Erwin Jiayuan Khoo, Robert D Schremmer, Douglas S Diekema, John D Lantos
When minors are asked to assist medical educators by acting as standardized patients (SPs), there is a potential for the minors to be exploited. Minors deserve protection from exploitation. Such protection has been written into regulations governing medical research and into child labor laws. But there are no similar guidelines for minors' work in medical education. This article addresses the question of whether there should be rules. Should minors be required to give their informed consent or assent? Are there certain practices that could cause harm for the children who become SPs? We present a controversial case and ask a number of experts to consider the ethical issues that arise when minors are asked to act as SPs in medical education...
February 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/28157587/health-and-work-in-the-family-evidence-from-spouses-cancer-diagnoses
#7
Sung-Hee Jeon, R Vincent Pohl
Using Canadian administrative data from multiple sources, we provide the first nationally representative estimates for the effect of spouses' cancer diagnoses on individuals' employment and earnings and on family income. Our identification strategy exploits unexpected health shocks and combines matching with individual fixed effects in a generalized difference-in-differences framework to control for observable and unobservable heterogeneity. While the effect of spousal health shocks on labor supply is theoretically ambiguous, we find strong evidence for a decline in employment and earnings of individuals whose spouses are diagnosed with cancer...
January 20, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28107164/decreasing-human-trafficking-through-sex-work-decriminalization
#8
Erin Albright, Kate D'Adamo
In order to decrease human trafficking, health care workers should support the full decriminalization of prostitution. Similar to trafficking in other forms of labor, preventing trafficking in the sex trade requires addressing the different forms of marginalization that create vulnerable communities. By removing punitive laws that prevent reporting of exploitation and abuse, decriminalization allows sex workers to work more safely, thereby reducing marginalization and vulnerability. Decriminalization can also help destigmatize sex work and help resist political, social, and cultural marginalization of sex workers...
January 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28035802/rapid-distinction-of-leucine-and-isoleucine-in-monoclonal-antibodies-using-nanoflow-lcms-n
#9
Dhanashri Bagal, Eddie Kast, Ping Cao
Monoclonal antibodies (mAbs) are large heterogeneous molecules that represent a growing class of therapeutics. De novo sequencing of mAbs becomes necessary when the original cell line or the cDNA is unavailable. An important feature in sequencing of mAbs is the discrimination of isobaric residues (Xle): leucine (Leu) and isoleucine (Ile). An incorrect identification of the Xle site, especially in the complementarity determining regions (CDRs), can result in the production of an antibody with severely compromised efficacy...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27870298/health-effects-of-short-term-fluctuations-in-macroeconomic-conditions-the-case-of-hypertension-for-older-americans
#10
Marco Angrisani, Jinkook Lee
We investigate the health effects of short-term macroeconomic fluctuations as described by changes in unemployment rate, house, and stock market price indexes. The 'Great Recession' provides the opportunity to conduct this analysis as it involved contemporaneous shocks to the labor, housing, and stock markets. Using panel data from the Health and Retirement Study over the period 2004-2010, we relate changes in hypertension status to changes in state-level unemployment rate and house prices and to changes in stock market prices...
November 2016: Health Economics
https://www.readbyqxmd.com/read/27836599/gold-aggregating-gold-a-novel-nanoparticle-biosensor-approach-for-the-direct-quantification-of-hepatitis-c-virus-rna-in-clinical-samples
#11
Sherif M Shawky, Ahmed M Awad, Walaa Allam, Mohamed H Alkordi, Sherif F El-Khamisy
The affordable and reliable detection of Hepatitis C Virus (HCV) RNA is a cornerstone in the management and control of infection, affecting approximately 3% of the global population. However, the existing technologies are expensive, labor intensive and time consuming, posing significant limitations to their wide-scale exploitation, particularly in economically deprived populations. Here, we utilized the unique optical and physicochemical properties of gold nanoparticles (AuNPs) to develop a novel assay platform shown to be rapid and robust in sensing and quantifying unamplified HCV RNA in clinical samples...
June 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27818531/worms-at-work-long-run-impacts-of-a-child-health-investment
#12
Sarah Baird, Joan Hamory Hicks, Michael Kremer, Edward Miguel
This study estimates long-run impacts of a child health investment, exploiting community-wide experimental variation in school-based deworming. The program increased labor supply among men and education among women, with accompanying shifts in labor market specialization. Ten years after deworming treatment, men who were eligible as boys stay enrolled for more years of primary school, work 17% more hours each week, spend more time in nonagricultural self-employment, are more likely to hold manufacturing jobs, and miss one fewer meal per week...
November 2016: Quarterly Journal of Economics
https://www.readbyqxmd.com/read/27818522/manufacturing-gender-inequality-in-the-new-economy-high-school-training-for-work-in-blue-collar-communities
#13
April Sutton, Amanda Bosky, Chandra Muller
Tensions between the demands of the knowledge-based economy and remaining, blue-collar jobs underlie renewed debates about whether schools should emphasize career and technical training or college-preparatory curricula. We add a gendered lens to this issue, given the male-dominated nature of blue-collar jobs and women's greater returns to college. Using the ELS:2002, this study exploits spatial variation in school curricula and jobs to investigate local dynamics that shape gender stratification. Results suggest a link between high school training and jobs in blue-collar communities that structures patterns of gender inequality into early adulthood...
August 2016: American Sociological Review
https://www.readbyqxmd.com/read/27801565/efficient-exploitation-of-separation-space-in-two-dimensional-liquid-chromatography-system-for-comprehensive-and-efficient-proteomic-analyses
#14
Hangyeore Lee, Dong-Gi Mun, Jeong Eun So, Jingi Bae, Hokeun Kim, Christophe Masselon, Sang-Won Lee
Proteomics aims to achieve complete profiling of the protein content and protein modifications in cells, tissues, and biofluids and to quantitatively determine changes in their abundances. This information serves to elucidate cellular processes and signaling pathways and to identify candidate protein biomarkers and/or therapeutic targets. Analyses must therefore be both comprehensive and efficient. Here, we present a novel online two-dimensional reverse-phase/reverse-phase liquid chromatography separation platform, which is based on a newly developed online noncontiguous fractionating and concatenating device (NCFC fractionator)...
December 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27764155/maltreatment-and-mental-health-outcomes-among-ultra-poor-children-in-burkina-faso-a-latent-class-analysis
#15
Leyla Ismayilova, Eleni Gaveras, Austin Blum, Alexice Tô-Camier, Rachel Nanema
OBJECTIVES: Research about the mental health of children in Francophone West Africa is scarce. This paper examines the relationships between adverse childhood experiences, including exposure to violence and exploitation, and mental health outcomes among children living in ultra-poverty in rural Burkina Faso. METHODS: This paper utilizes baseline data collected from 360 children ages 10-15 and 360 of their mothers recruited from twelve impoverished villages in the Nord Region of Burkina, located near the Sahel Desert and affected by extreme food insecurity...
2016: PloS One
https://www.readbyqxmd.com/read/27548816/critical-reflections-on-the-currently-leading-definition-of-sustainable-employability
#16
Bram Bi Fleuren, Andries de Grip, Nicole Wh Jansen, Imjert Kant, Fred Rh Zijlstra
Sustainable employability (SE) is an important topic as it deals with employees' abilities to function adequately at work and in the labor market throughout their working lives. However, until now there has been only one attempt to define SE in the international literature (1). This first definition is a valuable contribution to the field as it rightfully describes SE as a multidimensional concept, recognizes the importance of both employee and work characteristics, and acknowledges the inherently longitudinal nature of SE...
August 22, 2016: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/27537695/human-trafficking-the-role-of-medicine-in-interrupting-the-cycle-of-abuse-and-violence
#17
Wendy Macias-Konstantopoulos
Human trafficking, a form of modern slavery, is an egregious violation of human rights with profound personal and public health implications. It includes forced labor and sexual exploitation of both U.S. and non-U.S. citizens and has been reported in all 50 states. Victims of human trafficking are currently among the most abused and disenfranchised persons in society, and they face a wide range of negative health outcomes resulting from their subjugation and exploitation. Medicine has an important role to play in mitigating the devastating effects of human trafficking on individuals and society...
October 18, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27476008/prediction-of-protein-protein-interaction-via-co-occurring-aligned-pattern-clusters
#18
Antonio Sze-To, Sanderz Fung, En-Shiun Annie Lee, Andrew K C Wong
Predicting Protein-protein interaction (PPI) is important for making new discoveries in the molecular mechanisms inside a cell. Traditionally, new PPIs are identified through biochemical experiments but such methods are labor-intensive, expensive, time-consuming and technically ineffective due to high false positive rates. Sequence-based prediction is currently the most readily applicable and cost-effective method. It exploits known PPI Databases to construct classifiers for predicting unknown PPIs based only on sequence data without requiring any other prior knowledge...
July 27, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/27468393/extended-inclusive-fitness-theory-synergy-and-assortment-drives-the-evolutionary-dynamics-in-biology-and-economics
#19
REVIEW
Klaus Jaffe
W.D. Hamilton's Inclusive Fitness Theory explains the conditions that favor the emergence and maintenance of social cooperation. Today we know that these include direct and indirect benefits an agent obtains by its actions, and through interactions with kin and with genetically unrelated individuals. That is, in addition to kin-selection, assortation or homophily, and social synergies drive the evolution of cooperation. An Extended Inclusive Fitness Theory (EIFT) synthesizes the natural selection forces acting on biological evolution and on human economic interactions by assuming that natural selection driven by inclusive fitness produces agents with utility functions that exploit assortation and synergistic opportunities...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27393233/the-effect-of-schooling-on-mortality-new-evidence-from-50-000-swedish-twins
#20
Petter Lundborg, Carl Hampus Lyttkens, Paul Nystedt
By using historical data on about 50,000 twins born in Sweden during 1886-1958, we demonstrate a positive and statistically significant relationship between years of schooling and longevity. This relation remains almost unchanged when exploiting a twin fixed-effects design to control for the influence of genetics and shared family background. This result is robust to controlling for within-twin-pair differences in early-life health and cognitive ability, as proxied by birth weight and height, as well as to restricting the sample to MZ twins...
August 2016: Demography
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