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https://www.readbyqxmd.com/read/28449067/using-high-throughput-barcode-sequencing-to-efficiently-map-connectomes
#1
Ian D Peikon, Justus M Kebschull, Vasily V Vagin, Diana I Ravens, Yu-Chi Sun, Eric Brouzes, Ivan R Corrêa, Dario Bressan, Anthony M Zador
The function of a neural circuit is determined by the details of its synaptic connections. At present, the only available method for determining a neural wiring diagram with single synapse precision-a 'connectome'-is based on imaging methods that are slow, labor-intensive and expensive. Here, we present SYNseq, a method for converting the connectome into a form that can exploit the speed and low cost of modern high-throughput DNA sequencing. In SYNseq, each neuron is labeled with a unique random nucleotide sequence-an RNA 'barcode'-which is targeted to the synapse using engineered proteins...
April 26, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28422677/learning-sparse-representation-for-objective-image-retargeting-quality-assessment
#2
Qiuping Jiang, Feng Shao, Weisi Lin, Gangyi Jiang
The goal of image retargeting is to adapt source images to target displays with different sizes and aspect ratios. Different retargeting operators create different retargeted images, and a key problem is to evaluate the performance of each retargeting operator. Subjective evaluation is most reliable, but it is cumbersome and labor-consuming, and more importantly, it is hard to be embedded into online optimization systems. This paper focuses on exploring the effectiveness of sparse representation for objective image retargeting quality assessment...
April 13, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28420374/prevalence-and-associated-factors-of-common-mental-disorders-among-ethiopian-migrant-returnees-from-the-middle-east-and-south-africa
#3
Kassahun Habtamu, Abebaw Minaye, Waganesh A Zeleke
BACKGROUND: Ethiopian migrants to the Middle East and South Africa experience a range of problems at various stages of their migration including overwork, sleep deprivation, denial of food, emotional abuse, difficulty adapting to the host culture, salary denial, sexual abuse, labor exploitation, confiscation of their travel documents, confinement, denial of medication, lack of access to legal service and degrading attitude by employers, traffickers and smugglers. These experiences can be associated with different types of mental disorders...
April 19, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28409473/peroxisome-mini-libraries-systematic-approaches-to-study-peroxisomes-made-easy
#4
Noa Dahan, Maya Schuldiner, Einat Zalckvar
High-throughput methodologies have been extensively used in the budding yeast, Saccharomyces cerevisiae, to uncover fundamental principles of cell biology. Over the years, several collections of yeast strains (libraries) were built to enable systematic exploration of cellular functions. However, using these libraries experimentally is often labor intensive and restricted to laboratories that hold high throughput platforms. Utilizing the available full genome libraries we handpicked a subset of strains that represent all known and predicted peroxisomal proteins as well as proteins that have central roles in peroxisome biology...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28381086/automated-quantitative-enzyme-biosensing-in-24-well-microplates
#5
Somjai Teanphonkrang, Albert Schulte
We report a novel system for glucose estimation in model and real samples, utilizing enzyme-modified pencil leads (PL) as effective electrochemical biosensors for robotic substrate quantification in 24-well microplates. Electrochemically formed carboxyl groups on the surface of the graphite were cross-linked to amino groups in the enzyme so as to attach glucose oxidase to the PL surface. Automated amperometric sensing of glucose solutions in microtiter-plate wells used computer-controlled stepper motors to move the biosensor/counter/reference electrode assemblies sequentially between the samples...
April 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28374588/detection-of-the-lipopeptide-pam3csk4-using-a-hybridized-toll-like-receptor-electrochemical-sensor
#6
Zhe She, Kristin Topping, Tianxiao Ma, Tiantian Zhao, Wenxia Zhou, Ajar Kamal, Soha Ahmadi, Heinz-Bernhard Kraatz
Electrochemical detection of Pam3CSK4, a synthetic triacylated lipopeptide that mimics the structural moieties of its natural Gram negative bacterial pathogen-associated molecular pattern (PAMP) counterpart, has been achieved using hybridized toll-like receptors (TLR) combining TLR1 and TLR2 onto a single sensor surface. These sensors represent the first hybridized TLR sensors. The limit of detection for Pam3CSK4 attained was 7.5 μg/mL, which is within the same order of magnitude for that of the more labor-intensive and time-consuming cell-assay technique, 2...
April 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28373743/how-does-gender-affect-sustainable-intensification-of-cereal-production-in-the-west-african-sahel-evidence-from-burkina-faso
#7
Veronique Theriault, Melinda Smale, Hamza Haider
Better understanding of gender differences in the adoption of agricultural intensification strategies is crucial for designing effective policies to close the gender gap while sustainably enhancing farm productivity. We examine gender differences in adoption rates, likelihood and determinants of adopting strategy sets that enhance yields, protect crops, and restore soils in the West African Sahel, based on analysis of cereal production in Burkina Faso. Applying a multivariate probit model to a nationally representative household panel, we exploit the individual plot as unit of analysis and control for plot manager characteristics along with other covariates...
April 2017: World Development
https://www.readbyqxmd.com/read/28371793/ultrasound-standard-plane-detection-using-a-composite-neural-network-framework
#8
Hao Chen, Lingyun Wu, Qi Dou, Jing Qin, Shengli Li, Jie-Zhi Cheng, Dong Ni, Pheng-Ann Heng
Ultrasound (US) imaging is a widely used screening tool for obstetric examination and diagnosis. Accurate acquisition of fetal standard planes with key anatomical structures is very crucial for substantial biometric measurement and diagnosis. However, the standard plane acquisition is a labor-intensive task and requires operator equipped with a thorough knowledge of fetal anatomy. Therefore, automatic approaches are highly demanded in clinical practice to alleviate the workload and boost the examination efficiency...
March 30, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28319173/affinity-purification-of-human-m-calpain-through-an-intrinsically-disordered-inhibitor-calpastatin
#9
Hung Huy Nguyen, Mihaly Varadi, Peter Tompa, Kris Pauwels
Calpains are calcium-activated proteases that have biomedical and biotechnological potential. Their activity is tightly regulated by their endogenous inhibitor, calpastatin that binds to the enzyme only in the presence of calcium. Conventional approaches to purify calpain comprise multiple chromatographic steps, and are labor-intensive, leading to low yields. Here we report a new purification procedure for the human m-calpain based on its reversible calcium-mediated interaction with the intrinsically disordered calpastatin...
2017: PloS One
https://www.readbyqxmd.com/read/28293882/method-for-developing-optical-sensors-using-a-synthetic-dye-fluorescent-protein-fret-pair-and-computational-modeling-and-assessment
#10
Joshua A Mitchell, William H Zhang, Michel K Herde, Christian Henneberger, Harald Janovjak, Megan L O'Mara, Colin J Jackson
Biosensors that exploit Förster resonance energy transfer (FRET) can be used to visualize biological and physiological processes and are capable of providing detailed information in both spatial and temporal dimensions. In a FRET-based biosensor, substrate binding is associated with a change in the relative positions of two fluorophores, leading to a change in FRET efficiency that may be observed in the fluorescence spectrum. As a result, their design requires a ligand-binding protein that exhibits a conformational change upon binding...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28223522/conformational-dynamics-of-a-neurotransmitter-sodium-symporter-in-a-lipid-bilayer
#11
Suraj Adhikary, Daniel J Deredge, Anu Nagarajan, Lucy R Forrest, Patrick L Wintrode, Satinder K Singh
Neurotransmitter:sodium symporters (NSSs) are integral membrane proteins responsible for the sodium-dependent reuptake of small-molecule neurotransmitters from the synaptic cleft. The symporters for the biogenic amines serotonin (SERT), dopamine (DAT), and norepinephrine (NET) are targets of multiple psychoactive agents, and their dysfunction has been implicated in numerous neuropsychiatric ailments. LeuT, a thermostable eubacterial NSS homolog, has been exploited as a model protein for NSS members to canvass the conformational mechanism of transport with a combination of X-ray crystallography, cysteine accessibility, and solution spectroscopy...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28216797/disability-benefit-generosity-and-labor-force-withdrawal
#12
Kathleen J Mullen, Stefan Staubli
A key component for estimating the optimal size and structure of disability insurance (DI) programs is the elasticity of DI claiming with respect to benefit generosity. Yet, in many countries, including the United States, all workers face identical benefit schedules, which are a function of one's labor market history, making it difficult to separate the effect of the benefit level from the effect of unobserved preferences for work on individuals' claiming decisions. To circumvent this problem, we exploit exogenous variation in DI benefits in Austria arising from several reforms to its DI and old age pension system in the 1990s and 2000s...
November 2016: Journal of Public Economics
https://www.readbyqxmd.com/read/28182999/employment-effects-of-active-labor-market-programs-for-sick-listed-workers
#13
Anders Holm, Jan Høgelund, Mette Gørtz, Kristin Storck Rasmussen, Helle Sofie Bøje Houlberg
We use register data of 88,948 sick-listed workers in Denmark over the period 2008-2011 to investigate the effect of active labor market programs on the duration until returning to non-subsidized employment and the duration of this employment. To identify causal treatment effects, we exploit over-time variation in the use of active labor market programs in 98 job centers and time-to- event. We find that ordinary education and subsidized job training have significant positive employment effects. Subsidized job training has a large, positive effect on the transition into employment but no effect on the subsequent employment duration...
January 30, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28174202/ethics-rounds-ethical-concerns-when-minors-act-as-standardised-patients
#14
Erwin Jiayuan Khoo, Robert D Schremmer, Douglas S Diekema, John D Lantos
When minors are asked to assist medical educators by acting as standardized patients (SPs), there is a potential for the minors to be exploited. Minors deserve protection from exploitation. Such protection has been written into regulations governing medical research and into child labor laws. But there are no similar guidelines for minors' work in medical education. This article addresses the question of whether there should be rules. Should minors be required to give their informed consent or assent? Are there certain practices that could cause harm for the children who become SPs? We present a controversial case and ask a number of experts to consider the ethical issues that arise when minors are asked to act as SPs in medical education...
February 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/28157587/health-and-work-in-the-family-evidence-from-spouses-cancer-diagnoses
#15
Sung-Hee Jeon, R Vincent Pohl
Using Canadian administrative data from multiple sources, we provide the first nationally representative estimates for the effect of spouses' cancer diagnoses on individuals' employment and earnings and on family income. Our identification strategy exploits unexpected health shocks and combines matching with individual fixed effects in a generalized difference-in-differences framework to control for observable and unobservable heterogeneity. While the effect of spousal health shocks on labor supply is theoretically ambiguous, we find strong evidence for a decline in employment and earnings of individuals whose spouses are diagnosed with cancer...
January 20, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/28107164/decreasing-human-trafficking-through-sex-work-decriminalization
#16
Erin Albright, Kate D'Adamo
In order to decrease human trafficking, health care workers should support the full decriminalization of prostitution. Similar to trafficking in other forms of labor, preventing trafficking in the sex trade requires addressing the different forms of marginalization that create vulnerable communities. By removing punitive laws that prevent reporting of exploitation and abuse, decriminalization allows sex workers to work more safely, thereby reducing marginalization and vulnerability. Decriminalization can also help destigmatize sex work and help resist political, social, and cultural marginalization of sex workers...
January 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28035802/rapid-distinction-of-leucine-and-isoleucine-in-monoclonal-antibodies-using-nanoflow-lcms-n
#17
Dhanashri Bagal, Eddie Kast, Ping Cao
Monoclonal antibodies (mAbs) are large heterogeneous molecules that represent a growing class of therapeutics. De novo sequencing of mAbs becomes necessary when the original cell line or the cDNA is unavailable. An important feature in sequencing of mAbs is the discrimination of isobaric residues (Xle): leucine (Leu) and isoleucine (Ile). An incorrect identification of the Xle site, especially in the complementarity determining regions (CDRs), can result in the production of an antibody with severely compromised efficacy...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27870298/health-effects-of-short-term-fluctuations-in-macroeconomic-conditions-the-case-of-hypertension-for-older-americans
#18
Marco Angrisani, Jinkook Lee
We investigate the health effects of short-term macroeconomic fluctuations as described by changes in unemployment rate, house, and stock market price indexes. The 'Great Recession' provides the opportunity to conduct this analysis as it involved contemporaneous shocks to the labor, housing, and stock markets. Using panel data from the Health and Retirement Study over the period 2004-2010, we relate changes in hypertension status to changes in state-level unemployment rate and house prices and to changes in stock market prices...
November 2016: Health Economics
https://www.readbyqxmd.com/read/27836599/gold-aggregating-gold-a-novel-nanoparticle-biosensor-approach-for-the-direct-quantification-of-hepatitis-c-virus-rna-in-clinical-samples
#19
Sherif M Shawky, Ahmed M Awad, Walaa Allam, Mohamed H Alkordi, Sherif F El-Khamisy
The affordable and reliable detection of Hepatitis C Virus (HCV) RNA is a cornerstone in the management and control of infection, affecting approximately 3% of the global population. However, the existing technologies are expensive, labor intensive and time consuming, posing significant limitations to their wide-scale exploitation, particularly in economically deprived populations. Here, we utilized the unique optical and physicochemical properties of gold nanoparticles (AuNPs) to develop a novel assay platform shown to be rapid and robust in sensing and quantifying unamplified HCV RNA in clinical samples...
June 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27818531/worms-at-work-long-run-impacts-of-a-child-health-investment
#20
Sarah Baird, Joan Hamory Hicks, Michael Kremer, Edward Miguel
This study estimates long-run impacts of a child health investment, exploiting community-wide experimental variation in school-based deworming. The program increased labor supply among men and education among women, with accompanying shifts in labor market specialization. Ten years after deworming treatment, men who were eligible as boys stay enrolled for more years of primary school, work 17% more hours each week, spend more time in nonagricultural self-employment, are more likely to hold manufacturing jobs, and miss one fewer meal per week...
November 2016: Quarterly Journal of Economics
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