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https://www.readbyqxmd.com/read/27866469/the-effects-of-percutaneous-transluminal-coronary-intervention-on-biomarkers-of-oxidative-stress-in-the-erythrocytes-of-elderly-male-patients
#1
Karolina Szewczyk-Golec, Paweł Grzelakowski, Tomasz Ługowski, Józef Kędziora
OBJECTIVES: Oxidative stress plays a key role in the pathogenesis of coronary artery disease. The aim of this study was to compare the effects of percutaneous transluminal coronary angioplasty (PTCA) and elective coronary angiography (EC) on erythrocytic antioxidant defense in elderly male patients. METHODS: Twenty-three stable angina pectoris (SAP) patients undergoing PTCA and 18 patients with ischemic symptoms scheduled to undergo diagnostic EC were included in the study...
November 20, 2016: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27816594/electrochemical-sandwich-type-biosensors-for-%C3%AE-1-antitrypsin-with-carbon-nanotubes-and-alkaline-phosphatase-labeled-antibody-silver-nanoparticles
#2
Gangbing Zhu, Hye Jin Lee
A novel sandwich-type biosensor was developed for the electrochemical detection of α-1 antitrypsin (AAT, a recognized biomarker for Alzheimer's disease). The biosensor was composed of 3, 4, 9, 10-perylene tetracarboxylic acid/carbon nanotubes (PTCA-CNTs) as a sensing platform and alkaline phosphatase-labeled AAT antibody functionalized silver nanoparticles (ALP-AAT Ab-Ag NPs) as a signal enhancer. CNTs offer high surface area and good electrical conductivity. Importantly, Ag NPs could increase the amount of ALP on the sensing surface and the ALP could dephosphorylate 4-amino phenyl phosphate (APP) enzymatically to produce electroactive species 4-aminophenol (AP)...
September 25, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27803083/infected-pseudoaneurysm-of-the-left-anterior-descending-artery
#3
Ashish Madkaiker, Neethu Krishna, Natarajan Kumaraswamy, Praveen Varma
Primary percutaneous transluminal coronary angioplasty (PTCA) with the insertion of a stent is a well-established procedure for management of coronary artery disease. Infected pseudoaneurysms following PTCA and stenting are very rare and have poor outcomes if not managed properly. We are presenting a case of a man aged 50 years with infected pseudoaneurysm of the left anterior descending artery following multiple percutaneous interventions for coronary artery disease. In this paper, we have described the presentation, diagnosis and management of this patient and have discussed the aetiology and management options of infected pseudoaneurysm affecting coronary arteries...
November 1, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27783152/sex-specific-differences-in-risk-factors-for-in-hospital-mortality-and-complications-in-patients-with-acute-coronary-syndromes-an-observational-cohort-study
#4
Katarina Novak, Davorka Vrdoljak, Igor Jelaska, Josip Anđelo Borovac
BACKGROUND: The goal of this observational cohort study was to examine gender-specific differences in the incidence of acute coronary syndrome (ACS), in-hospital complications and mortality. METHODS: A cohort of 1550 patients with the primary diagnosis of ACS were enrolled in the study over a period of 4 years. The in-hospital mortality and complications were analyzed as the main outcome measures. RESULTS: Women were significantly older compared to men (71 ± 11 years vs...
October 25, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27744352/patient-dosimetry-during-interventional-cardiac-procedures-in-a-dedicated-catheterization-laboratory
#5
Satish C Uniyal, Vineet Chaturvedi, Sunil D Sharma, Anurag Rawat
Cardiac interventions often result in high radiation dose to patient's skin, so a reliable indicator in terms of a commonly used dose descriptor is required to monitor skin exposures. In the present study, Gafchromic XR-RV3 film was used to measure the peak skin dose (PSD) during 40 coronary angiography (CA) and 50 percutaneous transluminal coronary angioplasty (PTCA) procedures. Corresponding values of kerma-area product (PKA), fluoroscopy time (FT) and reference air-kerma (Ka,r) were recorded and correlated with PSD...
October 15, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27728050/a-clinical-study-on-evaluation-and-correlation-of-hs-crp-levels-in-patients-with-coronary-artery-disease-cad-who-underwent-ptca
#6
Raghu Kishore Galla, Lalitha N, Rama Kumara N, Seshagiri Rao D, Jyotsna Maddury
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27672505/tissue-and-serum-samples-of-patients-with-papillary-thyroid-cancer-with-and-without-benign-background-demonstrate-different-altered-expression-of-proteins
#7
Mardiaty Iryani Abdullah, Ching Chin Lee, Sarni Mat Junit, Khoon Leong Ng, Onn Haji Hashim
BACKGROUND: Papillary thyroid cancer (PTC) is mainly diagnosed using fine-needle aspiration biopsy. This most common form of well-differentiated thyroid cancer occurs with or without a background of benign thyroid goiter (BTG). METHODS: In the present study, a gel-based proteomics analysis was performed to analyse the expression of proteins in tissue and serum samples of PTC patients with (PTCb; n = 6) and without a history of BTG (PTCa; n = 8) relative to patients with BTG (n = 20)...
2016: PeerJ
https://www.readbyqxmd.com/read/27649335/an-ultrasensitive-electrochemiluminescence-immunosensor-for-nt-probnp-based-on-self-catalyzed-luminescence-emitter-coupled-with-pdcu-carbon-nanohorn-hybrid
#8
Yuting Liu, Haijun Wang, Chengyi Xiong, Yaqin Chai, Ruo Yuan
A novel electrochemiluminescence (ECL) signal amplified strategy based on self-catalyzed luminol derivative and carbon nanohorn-based hybrid for luminol/H2O2 system was firstly proposed, and applied to fabricate an ultrasensitive ECL immunosensor for the detection of N-terminal pro-brain natriuretic peptides (NT-proBNP). Initially, PdCu nanocubes supported single-walled carbon nanohorns (PdCu@SWCNHs) hybrid was successfully synthesized through a facile one-pot strategy. For signal tag fabrication, 3,4,9,10-perylenetetracarboxylic acid (PTCA) conjugated luminol (PTC-Lu) as a novel self-catalyzed luminescence emitter was prepared and then effectively immobilized on the PdCu@SWCNHs to form PTC-Lu/PdCu@SWCNHs nanocomposite via π-π stacking...
August 31, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27594866/self-management-of-coronary-heart-disease-in-older-patients-after-elective-percutaneous-transluminal-coronary-angioplasty
#9
Susan Dawkes, Graeme D Smith, Lawrie Elliott, Robert Raeside, Jayne H Donaldson
OBJECTIVE: To explore how older patients self-manage their coronary heart disease (CHD) after undergoing elective percutaneous transluminal coronary angioplasty (PTCA). METHODS: This mixed methods study used a sequential, explanatory design and recruited a convenience sample of patients (n = 93) approximately three months after elective PTCA. The study was conducted in two phases. Quantitative data collected in Phase 1 by means of a self-administered survey were subject to univariate and bivariate analysis...
July 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27541668/ozonetherapy-protects-from-in-stent-coronary-neointimal-proliferation-role-of-redoxins
#10
A Barone, M Otero-Losada, A M Grangeat, G Cao, F Azzato, A Rodríguez, J Milei
BACKGROUND: In-stent restenosis and poor re-endothelization usually follow percutaneous transluminal coronary angioplasty, even using drug-eluting stents, due to inflammation and oxidative stress. Medical ozone has antioxidant and anti-inflammatory properties and has not been evaluated in this context. OBJECTIVES: To evaluate whether ozonotherapy might reduce restenosis following bare metal stents implantation in relation to the redoxin system in pigs. METHODS: Twelve male Landrace pigs (51±9kg) underwent percutaneous transluminal circumflex coronary arteries bare metal stent implantation under heparine infusion and fluoroscopical guidance, using standard techniques...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27522056/assessment-of-patient-s-peak-skin-dose-using-gafchromic-films-during-interventional-cardiology-procedures-routine-experience-feedback
#11
J Greffier, G Moliner, F Pereira, L Cornillet, B Ledermann, L Schmutz, M Lomma, G Cayla, J P Beregi
To assess the interest of Gafchromic films in detection of patient's peak skin dose (PSD) in interventional cardiology. A prospective study of 112 patients was conducted (July-December 2015). Three diagnostic and therapeutic procedures were evaluated: coronary angiography (CA), coronary angiography and coronary angioplasty for one or two vessels disease (CA-PTCA) and coronary angioplasty of complex chronic total occlusion (CTO). Dosimetric indicators (DIs) were collected and PSD were measured with Gafchromic films...
August 13, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27496237/estimating-the-economic-burden-of-cardiovascular-events-in-patients-receiving-lipid-modifying-therapy-in-the-uk
#12
Mark D Danese, Michelle Gleeson, Lucie Kutikova, Robert I Griffiths, Ali Azough, Kamlesh Khunti, Sreenivasa Rao Kondapally Seshasai, Kausik K Ray
OBJECTIVES: To characterise the costs to the UK National Health Service of cardiovascular (CV) events among individuals receiving lipid-modifying therapy. DESIGN: Retrospective cohort study using Clinical Practice Research Datalink records from 2006 to 2012 to identify individuals with their first and second CV-related hospitalisations (first event and second event cohorts). Within-person differences were used to estimate CV-related outcomes. SETTING: Patients in the UK who had their first CV event between January 2006 and March 2012...
2016: BMJ Open
https://www.readbyqxmd.com/read/27489601/comparison-of-the-patient-radiation-exposure-during-coronary-angiography-and-angioplasty-procedures-using-trans-radial-and-trans-femoral-access
#13
Ali Tarighatnia, Amir Hossein Mohammad Alian, Morteza Ghojazadeh, Alir Reza Farajollahi
INTRODUCTION: Cardiac catheterization procedure through the trans-radial access (TRA) have shown many clinical advantages over the trans-femoral (TFA), but despite its advantages, there are serious concerns regarding higher possible radiation dose for the patients and operators in TRA. This study was planned to compare the patients' radiation dose associated with TRA and TFA during coronary angiography (CA) and percutaneous transluminal coronary angioplasty (PTCA). METHODS: Of 700 candidates for angiography, 326 patients were entered the study...
2016: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/27480783/-percutaneus-coronary-interventions-for-ostial-lesions
#14
J Wöhrle, S Markovic
An ostial lesion is defined as a lesion near to the ostium (≤3 mm) and is characterized by a rigid fibrotic texture with pronounced sclerosis associated with a very high tendency to recoil. Under certain circumstances this may lead to a modest primary interventional result accompanied by a higher complication rate and in particular a higher rate of restenosis. Ostial lesions of the right coronary artery in particular represent a greater challenge for percutaneous interventions with a higher rate of restenosis despite the introduction of various new techniques...
November 2016: Herz
https://www.readbyqxmd.com/read/27474970/novel-electrochemiluminescence-of-perylene-derivative-and-its-application-to-mercury-ion-detection-based-on-a-dual-amplification-strategy
#15
Jing Zhao, Yan-Mei Lei, Ya-Qin Chai, Ruo Yuan, Ying Zhuo
In this paper, a novel covalently crosslinked perylene derivative (PTC-PEI) composed of polyethylenimine (PEI) and perylenetetracarboxylic acid (PTCA) has been first investigated for cathodic electrochemiluminescence (ECL) in an aqueous system with dissolved O2 as coreactant. The promising novel ECL materials of PTC-PEI exhibited admirable physical and chemical stability and high ECL intensity, which held an alternative way to construct ECL sensor with improved sensitivity. Thus, it was applied to construct a dual amplified "signal-on" mercury ion (Hg(2+)) sensor by the employment of nicking endonuclease (NEase)-assisted target recycling and rolling circle amplification (RCA) for signal amplification...
December 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27313750/an-unusual-mediastinal-parathyroid-carcinoma-coproducing-pth-and-pthrp-a-case-report
#16
Chuangjie Cao, Chengyun Dou, Fuqin Chen, Yan Wang, Xiaoli Zhang, Hong Lai
Parathyroid carcinoma (PTCA) is a rare disease, and ectopic PTCA is particularly rare. Parathyroid hormone-related protein (PTHrP) expression in PTCA has not been previously described in the relevant literature to the best of our knowledge. The present study reports a unique case with a mediastinal parathyroid carcinoma producing parathyroid hormone (PTH) and PTHrP. A 53-year-old man presented with hyperparathyroidism symptoms, including fatigue, chest pain, dizziness, muscular soreness, polyuria, night sweats and renal stones...
June 2016: Oncology Letters
https://www.readbyqxmd.com/read/27250989/diagnostic-performance-of-parafibromin-immunohistochemical-staining-for-sporadic-parathyroid-carcinoma-a-meta-analysis
#17
Ya Hu, Quan Liao, Shaobo Cao, Xiang Gao, Yupei Zhao
It is a challenge to distinguish parathyroid carcinoma (PTCA) from benign parathyroid lesions without recurrence or metastasis. Parafibromin immunohistochemical (IHC) staining had been described for the diagnosis of PTCA. But great variations existed in the reported sensitivity and specificity among different studies. We conducted a meta-analysis to summarize the diagnostic accuracy of parafibromin staining for PTCA. Published studies from Pubmed, Embase, and Cochrane Library were searched using the combination of terms "parafibromin," "CDC73," "HRPT2," and "parathyroid...
June 1, 2016: Endocrine
https://www.readbyqxmd.com/read/27221608/geographic-and-socioeconomic-differences-in-access-to-revascularization-following-acute-myocardial-infarction
#18
Giuliana De Luca, Alessio Petrelli, Tania Landriscina, Roberto Gnavi, Massimo Giammaria, Giuseppe Costa
BACKGROUND: Geographic and socioeconomic barriers may hinder fair access to healthcare. This study assesses geographic and socioeconomic disparities in access to reperfusion procedures in acute myocardial infarction (AMI) patients residing in Piedmont (Italy). METHODS: Coronary Care Units (CCUs) were geocoded with a geographic information system (GIS) and the shortest drive time from CCUs to patients' residence was computed and categorized as 0 to <20, 20 to <40 and ≥40 min...
October 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/27200353/a-cross-sectional-study-of-klkb1-and-prcp-polymorphisms-in-patient-samples-with-cardiovascular-disease
#19
Haley R Gittleman, Alona Merkulova, Omar Alhalabi, Evi X Stavrou, Martina L Veigl, Jill S Barnholtz-Sloan, Alvin H Schmaier
Plasma kallikrein formed from prekallikrein (PK) produces bradykinin from kininogens and activates factor XII. Plasma PK is activated by factors αXIIa, βXIIa, or prolylcarboxypeptidase (PRCP). A cross-sectional investigation determined if there is an association of PRCP and KLKB1 polymorphisms with cardiovascular disease (CVD). DNA was obtained from 2243 individuals from the Prevention of Events with Angiotensin Converting Enzyme trial. Two PRCP SNPs, rs7104980 and rs2298668, and two KLKB1 SNPs, rs3733402 and rs3087505, were genotyped...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27151531/electrophysiological-effects-of-selective-atrial-coronary-artery-occlusion-in-humans
#20
Jesús Álvarez-García, Miquel Vives-Borrás, Pedro Gomis, Jordi Ordoñez-Llanos, Andreu Ferrero-Gregori, Antoni Serra-Peñaranda, Juan Cinca
BACKGROUND: The arrhythmogenesis of ventricular myocardial ischemia has been extensively studied, but models of atrial ischemia in humans are lacking. This study aimed at describing the electrophysiological alterations induced by acute atrial ischemia secondary to atrial coronary branch occlusion during elective coronary angioplasty. METHODS AND RESULTS: Clinical data, 12-lead ECG, 12-hour Holter recordings, coronary angiography, and serial plasma levels of high-sensitivity troponin T and midregional proatrial natriuretic peptide were prospectively analyzed in 109 patients undergoing elective angioplasty of right or circumflex coronary arteries...
June 7, 2016: Circulation
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