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Satish C Uniyal, Vineet Chaturvedi, Sunil D Sharma, Anurag Rawat
Cardiac interventions often result in high radiation dose to patient's skin, so a reliable indicator in terms of a commonly used dose descriptor is required to monitor skin exposures. In the present study, Gafchromic XR-RV3 film was used to measure the peak skin dose (PSD) during 40 coronary angiography (CA) and 50 percutaneous transluminal coronary angioplasty (PTCA) procedures. Corresponding values of kerma-area product (PKA), fluoroscopy time (FT) and reference air-kerma (Ka,r) were recorded and correlated with PSD...
October 15, 2016: Radiation Protection Dosimetry
Raghu Kishore Galla, Lalitha N, Rama Kumara N, Seshagiri Rao D, Jyotsna Maddury
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Mardiaty Iryani Abdullah, Ching Chin Lee, Sarni Mat Junit, Khoon Leong Ng, Onn Haji Hashim
BACKGROUND: Papillary thyroid cancer (PTC) is mainly diagnosed using fine-needle aspiration biopsy. This most common form of well-differentiated thyroid cancer occurs with or without a background of benign thyroid goiter (BTG). METHODS: In the present study, a gel-based proteomics analysis was performed to analyse the expression of proteins in tissue and serum samples of PTC patients with (PTCb; n = 6) and without a history of BTG (PTCa; n = 8) relative to patients with BTG (n = 20)...
2016: PeerJ
Yuting Liu, Haijun Wang, Chengyi Xiong, Yaqin Chai, Ruo Yuan
A novel electrochemiluminescence (ECL) signal amplified strategy based on self-catalyzed luminol derivative and carbon nanohorn-based hybrid for luminol/H2O2 system was firstly proposed, and applied to fabricate an ultrasensitive ECL immunosensor for the detection of N-terminal pro-brain natriuretic peptides (NT-proBNP). Initially, PdCu nanocubes supported single-walled carbon nanohorns (PdCu@SWCNHs) hybrid was successfully synthesized through a facile one-pot strategy. For signal tag fabrication, 3,4,9,10-perylenetetracarboxylic acid (PTCA) conjugated luminol (PTC-Lu) as a novel self-catalyzed luminescence emitter was prepared and then effectively immobilized on the PdCu@SWCNHs to form PTC-Lu/PdCu@SWCNHs nanocomposite via π-π stacking...
August 31, 2016: Biosensors & Bioelectronics
Susan Dawkes, Graeme D Smith, Lawrie Elliott, Robert Raeside, Jayne H Donaldson
OBJECTIVE: To explore how older patients self-manage their coronary heart disease (CHD) after undergoing elective percutaneous transluminal coronary angioplasty (PTCA). METHODS: This mixed methods study used a sequential, explanatory design and recruited a convenience sample of patients (n = 93) approximately three months after elective PTCA. The study was conducted in two phases. Quantitative data collected in Phase 1 by means of a self-administered survey were subject to univariate and bivariate analysis...
July 2016: Journal of Geriatric Cardiology: JGC
A Barone, M Otero-Losada, A M Grangeat, G Cao, F Azzato, A Rodríguez, J Milei
BACKGROUND: In-stent restenosis and poor re-endothelization usually follow percutaneous transluminal coronary angioplasty, even using drug-eluting stents, due to inflammation and oxidative stress. Medical ozone has antioxidant and anti-inflammatory properties and has not been evaluated in this context. OBJECTIVES: To evaluate whether ozonotherapy might reduce restenosis following bare metal stents implantation in relation to the redoxin system in pigs. METHODS: Twelve male Landrace pigs (51±9kg) underwent percutaneous transluminal circumflex coronary arteries bare metal stent implantation under heparine infusion and fluoroscopical guidance, using standard techniques...
November 15, 2016: International Journal of Cardiology
J Greffier, G Moliner, F Pereira, L Cornillet, B Ledermann, L Schmutz, M Lomma, G Cayla, J P Beregi
To assess the interest of Gafchromic films in detection of patient's peak skin dose (PSD) in interventional cardiology. A prospective study of 112 patients was conducted (July-December 2015). Three diagnostic and therapeutic procedures were evaluated: coronary angiography (CA), coronary angiography and coronary angioplasty for one or two vessels disease (CA-PTCA) and coronary angioplasty of complex chronic total occlusion (CTO). Dosimetric indicators (DIs) were collected and PSD were measured with Gafchromic films...
August 13, 2016: Radiation Protection Dosimetry
Mark D Danese, Michelle Gleeson, Lucie Kutikova, Robert I Griffiths, Ali Azough, Kamlesh Khunti, Sreenivasa Rao Kondapally Seshasai, Kausik K Ray
OBJECTIVES: To characterise the costs to the UK National Health Service of cardiovascular (CV) events among individuals receiving lipid-modifying therapy. DESIGN: Retrospective cohort study using Clinical Practice Research Datalink records from 2006 to 2012 to identify individuals with their first and second CV-related hospitalisations (first event and second event cohorts). Within-person differences were used to estimate CV-related outcomes. SETTING: Patients in the UK who had their first CV event between January 2006 and March 2012...
2016: BMJ Open
Ali Tarighatnia, Amir Hossein Mohammad Alian, Morteza Ghojazadeh, Alir Reza Farajollahi
INTRODUCTION: Cardiac catheterization procedure through the trans-radial access (TRA) have shown many clinical advantages over the trans-femoral (TFA), but despite its advantages, there are serious concerns regarding higher possible radiation dose for the patients and operators in TRA. This study was planned to compare the patients' radiation dose associated with TRA and TFA during coronary angiography (CA) and percutaneous transluminal coronary angioplasty (PTCA). METHODS: Of 700 candidates for angiography, 326 patients were entered the study...
2016: Journal of Cardiovascular and Thoracic Research
J Wöhrle, S Markovic
An ostial lesion is defined as a lesion near to the ostium (≤3 mm) and is characterized by a rigid fibrotic texture with pronounced sclerosis associated with a very high tendency to recoil. Under certain circumstances this may lead to a modest primary interventional result accompanied by a higher complication rate and in particular a higher rate of restenosis. Ostial lesions of the right coronary artery in particular represent a greater challenge for percutaneous interventions with a higher rate of restenosis despite the introduction of various new techniques...
August 1, 2016: Herz
Jing Zhao, Yan-Mei Lei, Ya-Qin Chai, Ruo Yuan, Ying Zhuo
In this paper, a novel covalently crosslinked perylene derivative (PTC-PEI) composed of polyethylenimine (PEI) and perylenetetracarboxylic acid (PTCA) has been first investigated for cathodic electrochemiluminescence (ECL) in an aqueous system with dissolved O2 as coreactant. The promising novel ECL materials of PTC-PEI exhibited admirable physical and chemical stability and high ECL intensity, which held an alternative way to construct ECL sensor with improved sensitivity. Thus, it was applied to construct a dual amplified "signal-on" mercury ion (Hg(2+)) sensor by the employment of nicking endonuclease (NEase)-assisted target recycling and rolling circle amplification (RCA) for signal amplification...
December 15, 2016: Biosensors & Bioelectronics
Chuangjie Cao, Chengyun Dou, Fuqin Chen, Yan Wang, Xiaoli Zhang, Hong Lai
Parathyroid carcinoma (PTCA) is a rare disease, and ectopic PTCA is particularly rare. Parathyroid hormone-related protein (PTHrP) expression in PTCA has not been previously described in the relevant literature to the best of our knowledge. The present study reports a unique case with a mediastinal parathyroid carcinoma producing parathyroid hormone (PTH) and PTHrP. A 53-year-old man presented with hyperparathyroidism symptoms, including fatigue, chest pain, dizziness, muscular soreness, polyuria, night sweats and renal stones...
June 2016: Oncology Letters
Ya Hu, Quan Liao, Shaobo Cao, Xiang Gao, Yupei Zhao
It is a challenge to distinguish parathyroid carcinoma (PTCA) from benign parathyroid lesions without recurrence or metastasis. Parafibromin immunohistochemical (IHC) staining had been described for the diagnosis of PTCA. But great variations existed in the reported sensitivity and specificity among different studies. We conducted a meta-analysis to summarize the diagnostic accuracy of parafibromin staining for PTCA. Published studies from Pubmed, Embase, and Cochrane Library were searched using the combination of terms "parafibromin," "CDC73," "HRPT2," and "parathyroid...
June 1, 2016: Endocrine
Giuliana De Luca, Alessio Petrelli, Tania Landriscina, Roberto Gnavi, Massimo Giammaria, Giuseppe Costa
BACKGROUND: Geographic and socioeconomic barriers may hinder fair access to healthcare. This study assesses geographic and socioeconomic disparities in access to reperfusion procedures in acute myocardial infarction (AMI) patients residing in Piedmont (Italy). METHODS: Coronary Care Units (CCUs) were geocoded with a geographic information system (GIS) and the shortest drive time from CCUs to patients' residence was computed and categorized as 0 to <20, 20 to <40 and ≥40 min...
May 23, 2016: European Journal of Public Health
Haley R Gittleman, Alona Merkulova, Omar Alhalabi, Evi X Stavrou, Martina L Veigl, Jill S Barnholtz-Sloan, Alvin H Schmaier
Plasma kallikrein formed from prekallikrein (PK) produces bradykinin from kininogens and activates factor XII. Plasma PK is activated by factors αXIIa, βXIIa, or prolylcarboxypeptidase (PRCP). A cross-sectional investigation determined if there is an association of PRCP and KLKB1 polymorphisms with cardiovascular disease (CVD). DNA was obtained from 2243 individuals from the Prevention of Events with Angiotensin Converting Enzyme trial. Two PRCP SNPs, rs7104980 and rs2298668, and two KLKB1 SNPs, rs3733402 and rs3087505, were genotyped...
2016: Frontiers in Medicine
Jesús Álvarez-García, Miquel Vives-Borrás, Pedro Gomis, Jordi Ordoñez-Llanos, Andreu Ferrero-Gregori, Antoni Serra-Peñaranda, Juan Cinca
BACKGROUND: The arrhythmogenesis of ventricular myocardial ischemia has been extensively studied, but models of atrial ischemia in humans are lacking. This study aimed at describing the electrophysiological alterations induced by acute atrial ischemia secondary to atrial coronary branch occlusion during elective coronary angioplasty. METHODS AND RESULTS: Clinical data, 12-lead ECG, 12-hour Holter recordings, coronary angiography, and serial plasma levels of high-sensitivity troponin T and midregional proatrial natriuretic peptide were prospectively analyzed in 109 patients undergoing elective angioplasty of right or circumflex coronary arteries...
June 7, 2016: Circulation
Yan-Mei Lei, Min Zhao, Ai Wang, Yan-Qing Yu, Ya-Qin Chai, Ruo Yuan, Ying Zhuo
In this work, an "on-off-on" switch system has been successfully applied through the construction of an electrochemiluminscent biosensor for copper ion (Cu(2+) ) detection based on a new electrochemiluminescence (ECL) emitter of supramolecular nanorods, which was achieved through supramolecular interactions between 3,4,9,10-perylenetetracarboxylic acid (PTCA) and aniline. The initial "signal-on" state with strong and stable ECL emission was obtained by use of the supramolecular nanorods with a new signal amplification strategy involving a co-reaction accelerator...
June 6, 2016: Chemistry: a European Journal
M K Saeed
The aim of this study was to evaluate dose area product (DAP) and skin dose to patients undergoing coronary angiography (CA) and percutaneous transluminal coronary angioplasty (PTCA) using GafChromic XR film at King Khalid Hospital, Najran, Saudi Arabia. The entrance skin doses (ESDs) were calculated from DAP using GafChromic XR film placed on the patients back. The mean DAP obtained for patients undergoing CA and PTCA examinations were found to be 31.4 and 74.2 Gy cm(2), respectively. The mean ESD using GafChromic XR film was found to be 0...
April 6, 2016: Radiation Protection Dosimetry
Freidoun Sabzi, Reza Faraji
A 73-year-old woman who had undergone coronary artery bypass grafting for coronary artery stenosis six years ago, presented with right lower extremity claudication. Angiography revealed right external artery stenosis. Elective external iliac PTCA was performed complicated with simultaneous external iliac artery and vein rupture that was an exceedingly rare event. Retroperitoneal laparotomy with repair of ruptures took done, but the patient died with post-operative multi-organ failure.
February 2016: Acta Medica Iranica
Jianfeng Lv, Xingmei Zhang, Shulin Ou, Shanshan Gu, Zhizhou Su, Shifei Tong, Bo Liu, Zhiyuan Song, Luxiang Chi
Cognitive behavioral therapy (CBT), established only a few decades ago, is widely used by clinical psychologists. This study aimed to investigate the effects of CBT on mental status and quality of life (QOL) after percutaneous coronary intervention (PCI) in young and middle-aged patients with coronary heart disease (CHD). Seventy-five anxiety/depression patients (mean age, 52.2 ± 6.2 years, including 8 individuals < 45 years old) with CHD treated with PCI were randomly divided into a CBT group (n = 38) and control group (n = 37)...
2016: International Heart Journal
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