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https://www.readbyqxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
https://www.readbyqxmd.com/read/29929165/high-throughput-label-free-microcontact-printing-graphene-based-biosensor-for-valley-fever
#2
Shih-Ming Tsai, Tyler Goshia, Yen-Chang Chen, Agnes Kagiri, Angelo Sibal, Meng-Hsuen Chiu, Anand Gadre, Vincent Tung, Wei-Chun Chin
The highly prevalent and virulent disease in the Western Hemisphere Coccidioidomycosis, also known as Valley Fever, can cause serious illness such as severe pneumonia with respiratory failure. It can also take on a disseminated form where the infection spreads throughout the body. Thus, a serious impetus exists to develop effective detection of the disease that can also operate in a rapid and high-throughput fashion. Here, we report the assembly of a highly sensitive biosensor using reduced graphene oxide (rGO) with Coccidioides(cocci) antibodies as the target analytes...
June 18, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29929152/when-the-heart-gets-the-flu-fulminant-influenza-b-myocarditis-a-case-series-report-and-review-of-the-literature
#3
Guillaume Hékimian, Tamara Jovanovic, Nicolas Bréchot, Guillaume Lebreton, Pascal Leprince, Jean-Louis Trouillet, Matthieu Schmidt, Ania Nieszkowska, Sébastien Besset, Jean Chastre, Alain Combes, Charles-Edouard Luyt
PURPOSE: To describe patients with refractory cardiogenic shock related to influenza B virus myocarditis rescued by venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). MATERIAL AND METHODS: Consecutive patients hospitalized in our unit for influenza-associated myocarditis were prospectively included. We also conducted a systematic MEDLINE database literature review through the PubMed search engine, between 1946 and 2017. RESULTS: We report the cases of 4 young patients with fulminant myocarditis requiring VA-ECMO for 6 [5-8] days...
June 9, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29929063/prevalence-bioserotyping-and-antibiotic-resistance-of-pathogenic-yersinia-enterocolitica-detected-in-pigs-at-slaughter-in-sardinia
#4
Federica Fois, Francesca Piras, Mia Torpdahl, Roberta Mazza, Daniela Ladu, Simonetta G Consolati, Carlo Spanu, Christian Scarano, Enrico P L De Santis
The aims of the present study were to determine Yersinia enterocolitica prevalence in finishing pigs and piglets at slaughter and to characterize the isolates in terms of bioserotype, virulence profile, antimicrobial susceptibility and genetic diversity. During the years 2013-2014, nine pig slaughterhouses placed in Sardinia (Italy) were visited twice, in order to collect animal samples and scalding water. Overall, 609 samples respectively of tonsils (126), colon content (161), mesenteric lymph nodes (161) and carcass surfaces (161) were collected from 126 finishing pigs and 35 piglets...
June 13, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29929057/serotype-a-of-aggregatibacter-actinomycetemcomitans-down-regulates-the-increased-serotype-b-induced-cytokine-and-chemokine-production-in-dendritic-cells
#5
Leticia Rojas, Samanta Melgar-Rodríguez, Jaime Díaz-Zúñiga, Carla Alvarez, Gustavo Monasterio, Carolina Rojas, Paola Carvajal, Rolando Vernal
OBJECTIVE: In Aggregatibacter actinomycetemcomitans, different serotypes have been described based on LPS antigenicity. Mixed infection with the different A. actinomycetemcomitans serotypes is frequent in periodontitis patients; accordingly, the role of this bacterial species in the pathogenesis of periodontitis may differ depending whether patients or periodontal lesions harbour one or more of the A. actinomycetemcomitans serotypes. We hypothesized that different combinations of these serotypes could be associated with distinct host responses and hence different inflammatory patterns...
June 12, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29929040/global-analysis-of-ubiquitome-in-prrsv-infected-pulmonary-alveolar-macrophages
#6
Huan Zhang, Liurong Fang, Xinyu Zhu, Dang Wang, Shaobo Xiao
Protein lysine ubiquitination is a dynamic reversible post-translational modification that plays key roles in modulating different cellular processes. Porcine reproductive and respiratory syndrome virus (PRRSV) is a notorious pathogen, causing tremendous economic losses for the global swine industry. The possible involvement of ubiquitination in PRRSV infection is unclear. So anti-ubiquitination-based enrichment and LC-MS were performed to investigate the global ubiquitination events triggered by PRRSV infection in pulmonary alveolar macrophages...
June 18, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29929022/risk-factors-for-surgical-site-infection-following-operative-treatment-of-ankle-fractures-a-systematic-review-and-meta-analysis
#7
REVIEW
Jiashen Shao, Huixin Zhang, Bing Yin, Jia Li, Yanbin Zhu, Yingze Zhang
BACKGROUND: This study aims to quantitatively summarize risk factors associated with surgical site infection after open reduction and internal fixation of ankle fractures. METHODS: Relevant original studies were searched in Medline, Embase, China National Knowledge Infrastructure, Wanfang database and Cochrane central database (all through April 2018). Studies eligible had to meet the quality assessment criteria by Newcastle-Ottawa Scale and to evaluate the risk factors for surgical site infection after open reduction and internal fixation of ankle fractures...
June 18, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29929018/beyond-routine-abortion-practice-identifying-adolescents-and-young-adults-at-risk-for-anemia
#8
Jessica Y Shim, Jessica M Madrigal, Juan Aparicio, Ashlesha Patel
STUDY OBJECTIVE: To evaluate the prevalence of anemia among female adolescents and young adults seeking abortion care at a county hospital, and to determine its associated factors. DESIGN: A cross-sectional retrospective study. SETTING: John H. Stroger, Jr. Hospital of Cook County, Chicago, IL. PARTICIPANTS: 2,916 young females (ages 11 to 24 years) who underwent first trimester medical or surgical termination in 2016...
June 18, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29929015/free-antero-lateral-thigh-flap-for-total-knee-prosthesis-coverage-after-infection-complicating-malignant-tumour-resection
#9
Cécile Philandrianos, Jean-Camille Mattei, Alexandre Rochwerger, Baptiste Bertrand, Charlotte Jaloux, Dominique Casanova
BACKGROUND: Infection is a common complication of major lower limb-sparing surgery with massive total knee prosthesis (MTKP) reconstruction after extensive tumour resection. When free tissue transfer is required to cover the prosthesis, musculo-cutaneous flaps are usually preferred based on proven efficacy when used in both one-stage and two-stage procedures. The use of a free fascio-cutaneous antero-lateral thigh (FC-ALT) flap in 3 patients with infected knee reconstructions is reported here...
June 18, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29929009/safety-immunogenicity-and-protection-of-a-h3n2-live-attenuated-influenza-vaccines-containing-wild-type-nucleoprotein-in-a-ferret-model
#10
Daniil A Korenkov, Karen L Laurie, Patrick C Reading, Louise A Carolan, Kok Fei Chan, Irina I Isakova-Sivak, Tatiana A Smolonogina, Kanta Subbarao, Ian G Barr, Julie Villanueva, Svetlana Shcherbik, Tatiana Bousse, Larisa G Rudenko
Live attenuated influenza vaccines (LAIVs) are promising tools for the induction of broad protection from influenza due to their ability to stimulate cross-reactive T cells against influenza pathogens. One of the major targets for cytotoxic T-cell immunity is viral nucleoprotein (NP), which is relatively conserved among antigenically distant influenza viruses. Nevertheless, a diversity of epitope composition has been found in the NP protein of different lineages of influenza A viruses. The H2N2 master donor virus which is currently used as a backbone for the LAIV and donor of the six genomic segments encoding the internal proteins, A/Leningrad/134/17/57 (MDV Len/17), was isolated 60 years ago...
June 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29928982/heterogeneity-and-the-origins-of-asthma
#11
REVIEW
Rebecca Scherzer, Mitchell H Grayson
OBJECTIVE: It is a well-known fact that there is significant heterogeneity in the origins of asthma in adults and children. This article examines the roots of asthma across the ages including atopy, the role of the microbiome and viral infections, along with comorbidities/confounders such as obesity, aspirin-exacerbated respiratory disease (AERD), neutrophilic asthma, cigarette smoking and the possibility of an asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome. DATA SOURCES: Data was taken from various scientific search engines including PubMed and Science Direct databases...
June 18, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29928976/characterization-of-quorum-sensing-system-in-clostridium-chauvoei
#12
Sujeet Kumar, Mohmad Mashooq, Ravi Kumar Gandham, S V Alavandi, Viswas Konasagara Nagaleekar
Clostridium chauvoei causes fatal black quarter infection in cattle and buffaloes. The quorum sensing (QS) system, a bacterial cell to cell communication process, of the pathogen was characterized in the current study. The results indicated that C. chauvoei lacked luxS (autoinducer-2) based quorum sensing as detected by the sensor strain Vibrio harveyi BB170. This was supported by absence of luxS gene in C. chauvoei genome. However, the genomic analysis indicated the presence of agrBD system in all three genomes of C...
June 18, 2018: Anaerobe
https://www.readbyqxmd.com/read/29928974/a-bio-guided-approach-for-the-development-of-a-chestnut-based-proanthocyanidin-enriched-nutraceutical-with-potential-anti-gastritis-properties
#13
Enrico Sangiovanni, Stefano Piazza, Urska Vrhovsek, Marco Fumagalli, Saba Khalilpour, Domenico Masuero, Chiara Di Lorenzo, Luca Colombo, Fulvio Mattivi, Emma De Fabiani, Mario Dell'Agli
Gastritis is a widely spread inflammatory disease, mostly caused by Helicobacter pylori infection. Release of IL-8 by the stomach epithelium is a hallmark of gastritis and contributes to the amplification of the inflammatory state. Pharmacological modulation of IL-8 release is a strategy to relieve gastric inflammation and prevent more severe clinical outcomes. In search of nutraceuticals with potential anti-gastritis properties we used a bio-guided approach based on IL-8 secretion by gastric cells to characterize extracts from the fruits of different chestnut varieties...
June 18, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29928942/interventions-to-decrease-short-term-peripheral-venous-catheter-related-bloodstream-infections-impact-on-incidence-and-mortality
#14
Patrick Saliba, Ana Hornero, Guillermo Cuervo, Immaculada Grau, Emilio Jimenez, Damaris Berbel, Purificación Martos, Juan Manuel Verge, Cristian Tebe, Jose María Martínez-Sánchez, Evelyn Shaw, Laura Gavaldà, Jordi Carratalà, Miquel Pujol
BACKGROUND: Short-term peripheral venous catheters are a significant source of health-care acquired bloodstream infections and a preventable cause of death. AIM: To assess the effectiveness of interventions applied to reduce the incidence and mortality associated with short peripheral venous catheter-related bloodstream infections (PVCR-BSI). METHODS: The intervention included continuous PVCR-BSI surveillance, implementation of preventive measures related to catheter insertion and maintenance in accordance with evidence-based recommendations and the hospital's own data, front-line staff educational campaigns, and assessment of adherence to hospital guidelines by ward rounds...
June 18, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29928941/nosocomial-outbreak-of-candida-parapsilosis-sensu-stricto-fungemia-in-a-neonatal-intensive-care-unit-in-china
#15
Lihua Qi, Weihong Fan, Xian Xia, Lu Yao, Lirui Liu, Haiyan Zhao, Xiangyong Kong, Jie Liu
BACKGROUND: Candida parapsilosis is a common agew2nt of fungemia, but few outbreaks of Candida parapsilosis infection have been reported in China. AIM: This study aimed to elaborate an outbreak of nosocomial Candida parapsilosis sensu stricto fungemia in a neonatal intensive care unit (NICU) of a comprehensive hospital in China from July to October 2017. METHODS: Epidemics and characteristics of fungemia cases were investigated. Surveillance samples were collected...
June 18, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29928920/joker-an-algorithm-to-insert-patterns-into-sequences-for-designing-antimicrobial-peptides-antimicrobial-peptides
#16
William F Porto, Isabel C M Fensterseifer, Suzana M Ribeiro, Octavio L Franco
The rise of bacterial resistance makes it necessary to find innovative alternatives to control bacterial infections. Antimicrobial peptides (AMPs) have been considered as the new generation of antimicrobial agents. Based on the fact that AMPs are sequence-dependent, a linguistic model for designing AMPs was previously developed. That model considers AMPs as a formal language with a grammar (patterns or motifs) and a vocabulary (amino acids). Albeit promising, that model has been poorly exploited mainly because it generates thousands of sequences, and the outcome has high similarity to already known AMPs...
June 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29928866/hepatitis-b-virus-promotes-proliferation-and-metastasis-in-male-chinese-hepatocellular-carcinoma-patients-through-the-lef-1-mir-371a-5p-srcin1-pleiotrophin-slug-pathway
#17
Pei-Song Bai, Peng Hou, Ying Kong
Hepatocellular carcinoma (HCC) is a male-dominant cancer. Several factors may contribute to the gender difference. Recent investigations have reported that miRNAs are involved in sex-linked signaling pathways and play a critical role in the molecular pathogenesis of hepatitis B virus (HBV)-related HCC. Therefore, we speculated that some of these miRNAs might contribute to the gender differences observed in HBV-related HCC. Our results showed that miR-371a-5p was significantly upregulated in tumor tissue and serum from HCC patients and that the expression level of miR-371a-5p was related to HBV infection, sexuality, TNM stage, adjacent organ invasion and microvascular invasion...
June 18, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29928848/retrospective-evaluation-of-fidaxomicin-versus-oral-vancomycin-for-treatment-of-clostridium-difficile-infections-in-allogeneic-stem-cell-transplant
#18
Laura Prohaska, Zahra Mahmoudjafari, Leyla Shune, Anurag Singh, Tara Lin, Sunil Abhyankar, Siddhartha Ganguly, Dennis Grauer, Joseph McGuirk, Lisa Clough
OBJECTIVE/BACKGROUND: Clostridium difficile infection (CDI) is a potential complication during hematopoietic stem cell transplantation (HSCT), and no specific recommendations exist regarding treatment of CDI in allogeneic SCT patients. Use of metronidazole and oral vancomycin has been associated with clinical failure. Fidaxomicin has previously been found noninferior to the use of oral vancomycin for the treatment of CDI, and no studies have compared the use of oral vancomycin with fidaxomicin for the treatment of CDI in allogeneic SCT...
June 18, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29928845/screening-for-latent-tuberculosis-infection-among-hiv-infected-medicaid-enrollees
#19
Eleanor E Friedman, Awal Khan, Wayne A Duffus
OBJECTIVES: In the United States, universal screening for latent tuberculosis (TB) infection among people with HIV is recommended, but the percentage receiving screening is unknown. This study assessed screening for latent TB infection among people with HIV enrolled in Medicaid during 2006-2010. METHODS: We used nationwide fee-for-service Medicaid records to identify people with HIV, measure screening for latent TB infection, and examine associated demographic, social, and clinical factors...
January 1, 2018: Public Health Reports
https://www.readbyqxmd.com/read/29928757/facultative-bacterial-endosymbionts-shape-parasitoid-food-webs-in-natural-host-populations-a-correlative-analysis
#20
Zhengpei Ye, Ines M G Vollhardt, Nadia Parth, Oskar Rubbmark, Michael Traugott
1.Facultative bacterial endosymbionts can protect their aphid hosts from natural enemies such as hymenopteran parasitoids. As such, they have the capability to modulate interactions between aphids, parasitoids and hyperparasitoids. However, the magnitude of these effects in natural aphid populations and their associated parasitoid communities is currently unknown. Moreover, environmental factors such as plant fertilization and landscape complexity are known to affect aphid-parasitoid interactions but it remains unclear how such environmental factors affect the interplay between aphids, parasitoids and endosymbionts...
June 21, 2018: Journal of Animal Ecology
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