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https://www.readbyqxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
https://www.readbyqxmd.com/read/28551927/-percutaneous-correction-of-forefoot-deformities-in-diabetic-patients-in-order-to-prevent-pressure-sores-technique-and-results-in-20-consecutive-patients
#2
Mustafa Yassin, Avraham Garti, Eyal Heller, Moshe Weissbrot, Dror Robinson
INTRODUCTION: Diabetes mellitus is a 21st century pandemic. Due to life-span prolongation combined with the increased rate of diabetes, a growing population of patients is afflicted with neuropathic foot deformities. Traditional operative repair of these deformities is associated with a high complication rate and relatively common infection incidence. In recent years, in order to prevent these complications, percutaneous deformity correction methods were developed. OBJECTIVES: Description of experience accumulated in treating 20 consecutive patients with diabetic neuropathic foot deformities treated in a percutaneous fashion...
April 2017: Harefuah
https://www.readbyqxmd.com/read/28551912/-bacteria-without-borders-a-high-carriage-rate-of-antibiotic-resistant-bacteria-among-syrian-children-hospitalized-in-galilee-medical-center
#3
Diana Faour Kassem, Naama Shahar, Smadar Ocampo, Tarif Bader, Zeev Zonis, Daniel Glikman
INTRODUCTION: As the civil war in Syria enters its fifth year, the Israeli government continues to provide humanitarian aid to Syrian civilians in Israeli hospitals. Many wounded Syrian children are treated at the Galilee Medical Center (GMC). Due to the patients' incomplete medical history and increasing infection rates in Syria, contact isolation and screening cultures for multi-drug resistant bacteria (MDR's) are conducted upon admission for all Syrian children. AIMS: To describe the rate of MDR carriage in Syrian children and compare it to hospitalized Israeli children...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551909/-dermatological-diseases-in-elderly-hospitalized-patients-in-the-galilee-medical-center-comparison-between-two-age-groups
#4
Maayan Lahav Sher, Orly Yakir, Ora Bitterman-Deutsch
INTRODUCTION: Although dermatologic conditions bring relatively few people to the Emergency Department, hospitalized patients, especially older people, often suffer from skin problems that contribute to their morbidity. AIMS: We wanted to identify the frequency, clinical course, treatment and influence on hospitalization of dermatologic conditions in patients hospitalized in internal and geriatric departments in Galilee Medical Center. We concentrated on two groups of adults, aged 40-65 years (adult group) and above 65 years (elderly group), in order to understand differences in the cause of referral, type of diagnosis and mode of treatment...
May 2017: Harefuah
https://www.readbyqxmd.com/read/28551896/-review-of-common-pathogens-in-the-bone-and-blood-cultures-and-antibiotic-treatment-in-patients-with-sternal-osteomyelitis
#5
Michal Benkler, Ori Shulman, Yoav Avrahamy, David Mendes, Yoav Arus, Ron Fishel, Amos Leviav, Dana Egozi
AIMS: This study concentrates on microbiological data collection of deep sternal wounds to delineate early and correct antibiotic therapy. BACKGROUND: Deep sternal wound infection, mediastinitis and sternal osteomyelitis are devastating and life-threatening complications of median-sternotomy incisions after cardiac surgical procedures. The incidence of surgical wound infection in sternotomies should be similar to that in any clean surgical procedure (i.e. approximately 2%)...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551894/-advanced-abdominal-pregnancy
#6
REVIEW
David Rabinerson, Alexandra Berezowsky, Rinnat Gabbay-Benziv
Abdominal pregnancy is a very rare obstetric complication which is seriously hazardous to the mother as well as the fetus. It poses a diagnostic challenge to this day. Both maternal and fetal mortality rates in such cases are high, as well as the malformation rate among the affected fetus. The best diagnostic tools are ultrasound and MRI. The availability of these instruments, and especially the latter, is scarce in developing countries, hence the higher rate of this type of pregnancy in these regions. The higher incidence of abdominal pregnancy in developing countries is also associated with the greater prevalence of low socioeconomic status, pelvic infections and infertility - all are more prevalent in these countries...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28551887/bacteriological-safety-assessment-hygienic-habits-and-cross-contamination-risks-in-a-nigerian-urban-sample-of-household-kitchen-environment
#7
Bernard O Ejechi, Ono P Ochei
Urban household kitchen environment was assessed for safety by determining their levels of indicator bacteria, hygienic habits and risk of cross-contamination. Household kitchens (60) were selected in Warri Town, Nigeria, by the multi-stage sampling technique. Contact surfaces, water and indoor kitchen air were analysed for aerobic plate counts, total and faecal coliforms using Nutrient and McConkey media by swab/rinse method, membrane filtration and sedimentation methods, respectively. Hygienic habits and risk of cross-contamination were assessed with structured questionnaire which included socio-demographic variables...
June 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28551853/complete-genome-sequences-of-two-novel-autographiviruses-infecting-a-bacterium-from-the-pseudomonas-fluorescens-group
#8
Grzegorz Nowicki, Karolina Walkowiak-Nowicka, Agata Zemleduch-Barylska, Anna Mleczko, Patryk Frąckowiak, Natalia Nowaczyk, Emilia Kozdrowska, Jakub Barylski
In this paper, we describe two independent isolates of a new member of the subfamily Autographivirinae, Pseudomonas phage KNP. The type strain (KNP) has a linear, 40,491-bp-long genome with GC content of 57.3%, and 50 coding DNA sequences (CDSs). The genome of the second strain (WRT) contains one CDS less, encodes a significantly different tail fiber protein and is shorter (40,214 bp; GC content, 57.4%). Phylogenetic analysis indicates that both KNP and WRT belong to the genus T7virus. Together with genetically similar Pseudomonas phages (gh-1, phiPSA2, phiPsa17, PPPL-1, shl2, phi15, PPpW-4, UNO-SLW4, phiIBB-PF7A, Pf-10, and Phi-S1), they form a divergent yet coherent group that stands apart from the T7-like viruses (sensu lato)...
May 27, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28551843/incidence-and-risk-factors-of-febrile-neutropenia-in-patients-with-non-hodgkin-b-cell-lymphoma-receiving-r-chop-in-a-single-center-in-japan
#9
Masahiro Yokoyama, Yoshiharu Kusano, Anna Takahashi, Norihito Inoue, Kyoko Ueda, Noriko Nishimura, Yuko Mishima, Yasuhito Terui, Tomoyuki Nukada, Takanobu Nomura, Kiyohiko Hatake
PURPOSE: The incidence of and risk factors for febrile neutropenia (FN) in Japanese non-Hodgkin B-cell lymphoma (B-NHL) patients receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and predonisolone (R-CHOP) chemotherapy are unknown. We conducted this study to address this issue. METHODS: In this single-center, retrospective, observational study, 466 patients with B-NHL who completed an R-CHOP regimen within a 7-year period and who planned to undergo at least three cycles of this regimen were analyzed...
May 27, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28551717/total-igm-and-anti-phosphatidylcholine-igm-antibody-secretion-continue-after-clearance-of-mycobacterium-bovis-bacillus-calmette-guerin-pleural-infection
#10
Ciara Ordoñez, Musharaf Tarajia, René Rivera, Dilcia Sambrano, Victoria Batista, Mónica Chávez, Denis Tapia, Patricia L Fernández, Amador Goodridge
The cellular immune response to Mycobacterium tuberculosis infection has been well characterized, while the humoral antibody response remains underexplored. We aimed to examine the total and anti-phospholipid IgM levels in the pleural lavage from mice with Mycobacterium bovis BCG extrapulmonary infection. We found that the levels of total and anti-phosphatidylcholine IgM antibodies remained significantly higher in infected mice as compared to non-infected mice up to day 90 after BCG infection, while the anti-cardiolipin IgM antibody levels decreased with bacteria clearance...
May 27, 2017: Lung
https://www.readbyqxmd.com/read/28551712/extracardiac-imaging-of-infective-endocarditis
#11
REVIEW
Xavier Duval, Bernard Iung
PURPOSE OF REVIEW: This review analyzes recent studies evaluating the diagnostic and therapeutic impacts of systematic extracardiac imaging techniques in patients with suspected or proven infective endocarditis. RECENT FINDINGS: Extracardiac imaging techniques are more and more frequently used to establish infective endocarditis (IE) diagnosis in doubtful situations. They also help in evaluating the risk-benefit balance of therapeutic strategies and particularly valvular surgery which is performed in approximately 50% of patients...
July 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28551700/macroautophagy-occurs-in-distal-tmv-uninfected-root-tip-tissue-of-tomato-taking-place-systemic-pcd
#12
Shumin Zhou, Qiang Hong, Yang Li, Qi Li, Ruisha Li, Hongli Zhang, Mao Wang, Xiaojun Yuan
Autophagy is an important mechanism for recycling cell materials upon encountering stress conditions. Our previous studies had shown that TMV infection could lead to systemic PCD in the distal uninfected tissues, including root tip and shoot tip tissues. But it is not clear whether there is autophagy in the distal apical meristem of TMV-induced plants. To better understand the autophagy process during systemic PCD, here we investigated the formation and type of autophagy in the root meristem cells occurring PCD...
May 27, 2017: Protoplasma
https://www.readbyqxmd.com/read/28551683/jc-virus-and-lung-adenocarcinoma-fact-or-myth
#13
Emanuele Sinagra, Dario Raimondo, Elena Gallo, Mario Stella, Mario Cottone, Francesca Rossi, Marco Messina, Massimiliano Spada, Giovanni Tomasello, Giuseppe Ferrara, Aroldo Gabriele Rizzo
BACKGROUND/AIM: An association has been reported between lung cancer and John Cunningham (JC) virus infection. The aim of this study was to evaluate the prevalence of JC virus in a small cohort of patients with lung adenocarcinoma and assess its presence in nodal metastasis. MATERIALS AND METHODS: Consecutive samples of 13 surgically-removed lung tumors and 13 surrounding normal cancer-free tissues were selected. Five cases included metastatic lymph nodes. JC virus infection was assessed through nested PCR...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551677/serum-levels-of-igf-1-and-igfbp-3-in-relation-to-clinical-and-pathobiological-aspects-of-head-and-neck-squamous-cell-carcinomas
#14
David Kalfert, Marie Ludvikova, Ondrej Topolcan, Petr Celakovsky, Radek Kucera, Jindra Windrichova, Jaroslav Ludvik, Katerina Skalova, Vlastimil Kulda, Martin Pesta, Jan Plzak
BACKGROUND/AIM: Head and neck squamous cell carcinoma (HNSCC) includes tumors of various anatomical sites sharing multifactorial etiopathogenesis and generally dismal response to conventional treatment. The objective of this study was to determine the clinical significance of serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in HNSCC. PATIENTS AND METHODS: A total of 46 patients, with histologically-confirmed diagnosis of HNSCC (21 oropharyngeal, 21 laryngeal, and 4 hypopharyngeal cancers) were enrolled in this study...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551668/occupational-risk-for-oral-cancer-in-nordic-countries
#15
Laura Tarvainen, Juho Suojanen, Pentti Kyyronen, Christian Lindqvist, Jan Ivar Martinsen, Kristina Kjaerheim, Elsebeth Lynge, Par Sparen, Laufey Tryggvadottir, Elisabete Weiderpass, Eero Pukkala
AIM: To evaluate occupational risk for cancer of the tongue, oral cavity or pharynx after adjustment for alcohol and tobacco use. MATERIALS AND METHODS: The data covered 14.9 million people and 28,623 cases of cancer of the tongue, oral cavity and pharynx in the Nordic countries 1961-2005. Alcohol consumption by occupation was estimated based on mortality from liver cirrhosis and incidence of liver cancer. Smoking by occupation was estimated based on the incidence of lung cancer...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551639/a-novel-near-infrared-fluorescent-protein-irfp720-facilitates-transcriptional-profiling-of-prostate-cancer-bone-metastasis-in-mice
#16
Mariko Honda, Satomi Yogosawa, Minori Kamada, Yuko Kamata, Takahiro Kimura, Yusuke Koike, Toru Harada, Hiroyuki Takahashi, Shin Egawa, Kiyotsugu Yoshida
BACKGROUND: Bone represents a frequent site of prostate cancer metastasis. As the molecular mechanism remains unclear, an accessible animal model is required. MATERIALS AND METHODS: We established a novel murine metastasis model using near-infrared fluorescent protein iRFP720-labelled prostate cancer (PC3) cells. To clarify transcriptional alterations during metastasis, iRFP720-PC3 cells were intracardially injected into male mice. mRNA expression profiles of metastasis in bone using marrow cancer cells extracted by centrifugal separation and cell sorting were compared with those of parental cells by microarray...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551625/intrahepatic-hcv-rna-level-and-genotype-1-independently-associate-with-hepatic-reticulon-3-expression
#17
Chih-Lang Lin, Rong-Nan Chien, Kung-Hao Liang, Po-Yuan Ke, Ya-Hui Huang, Chau-Ting Yeh
Background /Aim: Reticulon 3 (RTN3), resides predominantly in the endoplasmic reticulum and has opposite regulatory effects on Hepatitis C virus (HCV) replication through interacting with NS5A and NS4B proteins. This study aimed to unravel the actual effect of RTN3 on HCV replication. MATERIALS AND METHODS: A total of 115 HCV-related hepatocellular carcinoma patients receiving hepatectomy was enrolled in this study. The hepatic HCV RNA and RTN3 protein levels in the non-cancerous liver tissues were examined for clinical analysis...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551603/vibrio-vulnificus-septic-shock-due-to-a-contaminated-tattoo
#18
Nicholas Hendren, Senthil Sukumar, Craig S Glazer
We present a case of Vibrio vulnificus septic shock and cellulitis in a patient with chronic liver disease that occurred after obtaining a leg tattoo with subsequent seawater exposure in the Gulf of Mexico. Initial suspicion for V. vulnificus was high and he was started on empiric doxycycline and ceftriaxone at admission. Blood and wound cultures grew oxidase positive and comma-shaped Gram-negative rods ultimately confirmed to be V. vulnificus. Despite aggressive initial treatment, the patient developed septic shock and died...
May 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28551599/a-rare-cause-of-acute-dysphagia-acute-calcific-tendonitis-of-the-longus-colli-muscle
#19
Hanadi Abou Dargham, Faton Bytyci, Christian Shuman, Anton Stolear
We are presenting a case of a 78-year-old female with multiple comorbidities and history of neck surgery, who presented with acute dysphagia, odynophagia and neck pain that has been progressively getting worse over the course of 2 days, with no recent injury or infection. The patient was afebrile. There were no visible signs of infection on routine oropharyngeal examination. Initial workup was unremarkable except for elevated erythrocyte sedimentation rate, C-reactive protein and creatinine. CT of the cervical spine ruled out any fracture or cervical spine injury but showed an area of calcification, prevertebral oedema and fluid collection inferior to the anterior arch of C1...
May 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28551598/novel-variant-of-common-variable-immunodeficiency
#20
Eileen Conaway
A 57-year-old woman with frequent respiratory infections was initially diagnosed with IgG subclass deficiency based on low levels of IgG subclasses 2 and 3. Three years later, she progressed to having IgA deficiency as well. With a normal total IgG level, she does not meet criteria for common variable immunodeficiency (CVID). This may represent a variant of CVID. This also highlights the importance of immunoglobulin subclass estimation in patients where immunodeficiency is suspected clinically. She is being treated with rotational antibiotics the first 10 days of every month, monthly intravenous immunoglobulin (IVIG) infusion and osteopathic manipulation one to two times per month...
May 27, 2017: BMJ Case Reports
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